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DE60035049D1 - Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung - Google Patents

Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung

Info

Publication number
DE60035049D1
DE60035049D1 DE60035049T DE60035049T DE60035049D1 DE 60035049 D1 DE60035049 D1 DE 60035049D1 DE 60035049 T DE60035049 T DE 60035049T DE 60035049 T DE60035049 T DE 60035049T DE 60035049 D1 DE60035049 D1 DE 60035049D1
Authority
DE
Germany
Prior art keywords
metastasisation
interleukin
inhibitors
inhibiting tumor
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60035049T
Other languages
English (en)
Other versions
DE60035049T2 (de
Inventor
Charles Dinarello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ares Trading SA
Original Assignee
Ares Trading SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading SA filed Critical Ares Trading SA
Application granted granted Critical
Publication of DE60035049D1 publication Critical patent/DE60035049D1/de
Publication of DE60035049T2 publication Critical patent/DE60035049T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60035049T 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung Expired - Lifetime DE60035049T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
IL13104799 1999-07-22
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis

Publications (2)

Publication Number Publication Date
DE60035049D1 true DE60035049D1 (de) 2007-07-12
DE60035049T2 DE60035049T2 (de) 2007-09-27

Family

ID=11073044

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1206274T Pending DE1206274T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung
DE60035049T Expired - Lifetime DE60035049T2 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1206274T Pending DE1206274T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung

Country Status (31)

Country Link
US (1) US7741276B2 (de)
EP (1) EP1206274B1 (de)
JP (1) JP4827352B2 (de)
KR (1) KR100682219B1 (de)
CN (1) CN1173736C (de)
AR (1) AR024907A1 (de)
AT (1) ATE363288T1 (de)
AU (1) AU782478B2 (de)
BG (1) BG65800B1 (de)
BR (1) BR0012675A (de)
CA (1) CA2380216C (de)
CY (1) CY1107932T1 (de)
CZ (1) CZ302114B6 (de)
DE (2) DE1206274T1 (de)
DK (1) DK1206274T3 (de)
EA (1) EA005419B1 (de)
EE (1) EE04838B1 (de)
ES (1) ES2186596T3 (de)
HK (1) HK1048248B (de)
HU (1) HU228780B1 (de)
IL (2) IL131047A0 (de)
MX (1) MXPA02000838A (de)
NO (1) NO329827B1 (de)
NZ (1) NZ516535A (de)
PL (1) PL202477B1 (de)
PT (1) PT1206274E (de)
SK (1) SK287522B6 (de)
TR (1) TR200200169T2 (de)
UA (1) UA73745C2 (de)
WO (1) WO2001007480A2 (de)
ZA (1) ZA200200390B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001236807A1 (en) * 2000-02-10 2001-08-20 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
EP1425028B1 (de) * 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Verwendung von il-18-hemmern zur behandlung oder prävention von sepsis
RU2225720C1 (ru) * 2002-08-12 2004-03-20 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Средство, повышающее противоопухолевую и антиметастатическую активность циклофосфана
MXPA05003869A (es) * 2002-10-08 2005-06-22 Ares Trading Sa El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina.
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
ES2375831T3 (es) 2005-06-10 2012-03-06 Ares Trading S.A. Procedimiento para la purificación de prote�?nas de unión a il-18.
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
IL314346A (en) 2022-03-15 2024-09-01 Compugen Ltd Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment
JP2026503273A (ja) 2023-01-06 2026-01-28 ラッセン・セラピューティクス・インコーポレイテッド 抗ｉｌ－１８ｂｐ抗体
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU673193B2 (en) * 1992-09-02 1996-10-31 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
JP2002504091A (ja) * 1997-03-18 2002-02-05 ベーアーエスエフ アクツィエンゲゼルシャフト コルチコステロイドに対する応答性を調整するための方法及び組成物
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
BG65800B1 (bg) 2009-12-31
NO20020153D0 (no) 2002-01-11
CA2380216C (en) 2012-01-31
JP2003505472A (ja) 2003-02-12
CZ2002195A3 (cs) 2002-06-12
PT1206274E (pt) 2007-07-06
ES2186596T3 (es) 2007-11-16
CA2380216A1 (en) 2001-02-01
PL202477B1 (pl) 2009-06-30
IL131047A0 (en) 2001-01-28
BR0012675A (pt) 2002-04-09
HUP0202107A3 (en) 2005-01-28
HK1048248B (zh) 2005-04-22
BG106311A (en) 2002-08-30
NO329827B1 (no) 2011-01-03
UA73745C2 (en) 2005-09-15
NZ516535A (en) 2004-04-30
KR100682219B1 (ko) 2007-02-12
AR024907A1 (es) 2002-10-30
SK287522B6 (sk) 2011-01-04
TR200200169T2 (tr) 2002-06-21
BRPI0012675B1 (pt) 2001-02-01
ZA200200390B (en) 2003-04-30
BRPI0012675B8 (de) 2021-05-25
ATE363288T1 (de) 2007-06-15
AU5843200A (en) 2001-02-13
HU228780B1 (en) 2013-05-28
KR20020027493A (ko) 2002-04-13
JP4827352B2 (ja) 2011-11-30
CN1364086A (zh) 2002-08-14
MXPA02000838A (es) 2002-07-30
US20080003216A1 (en) 2008-01-03
DK1206274T3 (da) 2007-08-13
CZ302114B6 (cs) 2010-10-20
HUP0202107A2 (en) 2002-10-28
DE1206274T1 (de) 2002-11-14
EA200200189A1 (ru) 2002-12-26
DE60035049T2 (de) 2007-09-27
PL353732A1 (en) 2003-12-01
SK882002A3 (en) 2002-07-02
CN1173736C (zh) 2004-11-03
EP1206274B1 (de) 2007-05-30
EE04838B1 (et) 2007-06-15
WO2001007480A3 (en) 2001-05-10
EP1206274A2 (de) 2002-05-22
EE200200032A (et) 2003-02-17
CY1107932T1 (el) 2013-09-04
EA005419B1 (ru) 2005-02-24
HK1048248A1 (en) 2003-03-28
AU782478B2 (en) 2005-08-04
NO20020153L (no) 2002-03-11
ES2186596T1 (es) 2003-05-16
IL147675A (en) 2009-05-04
US7741276B2 (en) 2010-06-22
WO2001007480A2 (en) 2001-02-01

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Legal Events

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8364 No opposition during term of opposition