[go: up one dir, main page]

DE60034354D1 - Verbindungen zum schutz von hydroxylgruppen und ihre anwendung - Google Patents

Verbindungen zum schutz von hydroxylgruppen und ihre anwendung

Info

Publication number
DE60034354D1
DE60034354D1 DE60034354T DE60034354T DE60034354D1 DE 60034354 D1 DE60034354 D1 DE 60034354D1 DE 60034354 T DE60034354 T DE 60034354T DE 60034354 T DE60034354 T DE 60034354T DE 60034354 D1 DE60034354 D1 DE 60034354D1
Authority
DE
Germany
Prior art keywords
sup
line
formulae
compounds
hydroxyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034354T
Other languages
English (en)
Other versions
DE60034354T2 (de
Inventor
Marek Kwiatkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helicos BioSciences Corp
Original Assignee
Helicos BioSciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicos BioSciences Corp filed Critical Helicos BioSciences Corp
Publication of DE60034354D1 publication Critical patent/DE60034354D1/de
Application granted granted Critical
Publication of DE60034354T2 publication Critical patent/DE60034354T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60034354T 1999-10-05 2000-10-05 Verbindungen zum schutz von hydroxylgruppen und ihre anwendung Expired - Lifetime DE60034354T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/412,171 US6309836B1 (en) 1999-10-05 1999-10-05 Compounds for protecting hydroxyls and methods for their use
US412171 1999-10-05
PCT/SE2000/001929 WO2001025247A1 (en) 1999-10-05 2000-10-05 Compounds for protecting hydroxyls and methods for their use

Publications (2)

Publication Number Publication Date
DE60034354D1 true DE60034354D1 (de) 2007-05-24
DE60034354T2 DE60034354T2 (de) 2007-12-20

Family

ID=23631891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034354T Expired - Lifetime DE60034354T2 (de) 1999-10-05 2000-10-05 Verbindungen zum schutz von hydroxylgruppen und ihre anwendung

Country Status (8)

Country Link
US (3) US6309836B1 (de)
EP (1) EP1218391B1 (de)
JP (1) JP2003511386A (de)
AT (1) ATE359289T1 (de)
AU (1) AU7979200A (de)
CA (1) CA2386221C (de)
DE (1) DE60034354T2 (de)
WO (1) WO2001025247A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035012A2 (en) 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6309836B1 (en) * 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
EP1337541B1 (de) 2000-10-06 2007-03-07 The Trustees of Columbia University in the City of New York Massives Parallelverfahren zur Dekodierung von DNA und RNA
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
DE10120797B4 (de) * 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
DE10120798B4 (de) * 2001-04-27 2005-12-29 Genovoxx Gmbh Verfahren zur Bestimmung der Genexpression
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US20030153741A1 (en) * 2002-02-08 2003-08-14 Marek Kwiatkowski Methods for separating oligonucleotides
DE10214395A1 (de) * 2002-03-30 2003-10-23 Dmitri Tcherkassov Verfahren zur Analyse von Einzelnukleotidpolymorphismen
US20030228611A1 (en) * 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
EP2607369B1 (de) 2002-08-23 2015-09-23 Illumina Cambridge Limited Modifizierte Nucleotide zur Polynucleotidsequenzierung
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
EP1560838B1 (de) 2002-08-23 2009-05-13 Illumina Cambridge Limited Markierte nukleotide
US7345163B2 (en) * 2002-08-28 2008-03-18 Quiatech Ab Process for separating and deprotecting oligonucleotides
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
EP1725572B1 (de) 2003-11-05 2017-05-31 AGCT GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20060172408A1 (en) * 2003-12-01 2006-08-03 Quake Steven R Device for immobilizing chemical and biochemical species and methods of using same
CA2557177A1 (en) 2004-02-19 2005-09-01 Stephen Quake Methods and kits for analyzing polynucleotide sequences
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
US7635562B2 (en) 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
EP1879906A4 (de) * 2005-01-05 2009-07-22 Advanced Genetic Analysis Corp Umkehrbare nukleotidterminatoren und verwendungen davon
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
EP2233583A1 (de) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
EP2316977A1 (de) 2005-02-01 2011-05-04 AB Advanced Genetic Analysis Corporation Reagentien, Verfahren und Bibliotheken zur Amplifizierung mit Kügelchen
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
GB2446083B (en) 2005-10-31 2011-03-02 Univ Columbia Chemically cleavable 3'-0-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
WO2007053702A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
US20070117102A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
JP2009538123A (ja) * 2006-04-19 2009-11-05 アプライド バイオシステムズ， エルエルシー ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
WO2008037568A2 (en) * 2006-09-04 2008-04-03 Quiatech Ab Reversible terminators for efficient sequencing by synthesis
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US8612161B2 (en) * 2008-03-19 2013-12-17 Intelligent Biosystems Inc. Methods and compositions for base calling nucleic acids
US7881933B2 (en) * 2007-03-23 2011-02-01 Verizon Patent And Licensing Inc. Age determination using speech
US20090062132A1 (en) * 2007-08-29 2009-03-05 Borner Scott R Alternative nucleic acid sequencing methods
EP2725107B1 (de) 2007-10-19 2018-08-29 The Trustees of Columbia University in the City of New York DNA-Sequenzierung mit nichtfluoreszierenden, reversiblen Nukleotidterminatoren und spaltbaren, fluoreszierenden ddNTPs und Nukleinsäuren die Inosine mit reversiblen Terminatorgruppe
EP2940029B1 (de) 2007-10-19 2023-11-29 The Trustees of Columbia University in the City of New York Design und synthese von spaltbaren fluoreszierenden nukleotiden als reversible terminatoren zur dna-sequenzierung durch synthese
US20090156412A1 (en) * 2007-12-17 2009-06-18 Helicos Biosciences Corporation Surface-capture of target nucleic acids
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
JP5712125B2 (ja) 2008-05-27 2015-05-07 トリリンク バイオテクノロジーズ 高温で開始される核酸増幅のための、化学修飾されたヌクレオシド５’−三リン酸
US20100120034A1 (en) * 2008-07-03 2010-05-13 Life Technologies Corporation Methylation analysis of mate pairs
EP3067359A1 (de) * 2008-09-23 2016-09-14 Scott G. Petersen Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz
US10022454B2 (en) 2008-09-23 2018-07-17 Liposciences, Llc Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
US20100330569A1 (en) 2009-04-23 2010-12-30 Intelligent Bio-Systems, Inc. Hydroxymethyl Linkers For Labeling Nucleotides
WO2010141390A2 (en) * 2009-06-05 2010-12-09 Life Technologies Corporation Nucleotide transient binding for sequencing methods
KR101107315B1 (ko) * 2009-09-29 2012-01-20 한국과학기술연구원 ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ｄｎａ 염기서열 분석 방법
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
DE102009046981A1 (de) * 2009-11-23 2011-06-01 Ernst-Moritz-Arndt-Universität Greifswald Verfahren zur Herstellung von Trinukleotiden
DE102009046982A1 (de) * 2009-11-23 2011-06-01 Ernst-Moritz-Arndt-Universität Greifswald Festphasengebundene Nukleoside
SG186787A1 (en) 2010-07-23 2013-02-28 Esoterix Genetic Lab Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012146377A1 (de) 2011-04-27 2012-11-01 Dmitry Cherkasov Methoden und komponenten zur detektion von nukleinsäureketten
DE102012008759A1 (de) 2011-05-04 2012-11-08 Genovoxx Gmbh Nukleosid-Triphosphat-Konjugate und Methoden zu deren Anwendung
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
EP2734208B1 (de) * 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Verfahren zur synthese von funktionalisierten nukleinsäuren
CN104603287B (zh) 2012-05-10 2018-01-19 通用医疗公司 用于测定核苷酸序列的方法
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
WO2014139596A1 (en) 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
US9279149B2 (en) 2013-04-02 2016-03-08 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acids
US8808989B1 (en) 2013-04-02 2014-08-19 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acids
US10683536B2 (en) 2013-04-02 2020-06-16 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US9771613B2 (en) 2013-04-02 2017-09-26 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acid
US11331643B2 (en) 2013-04-02 2022-05-17 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US11384377B2 (en) 2013-04-02 2022-07-12 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
US10450597B2 (en) 2014-01-27 2019-10-22 The General Hospital Corporation Methods of preparing nucleic acids for sequencing
EP4328245A3 (de) 2014-07-15 2024-06-05 Kymab Ltd. Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
EP3332790A1 (de) 2014-07-15 2018-06-13 Kymab Limited Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
DE202015009002U1 (de) 2014-07-15 2016-08-18 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
WO2016023916A1 (en) 2014-08-12 2016-02-18 Kymab Limited Treatment of disease using ligand binding to targets of interest
EP3699283A1 (de) 2014-10-20 2020-08-26 Molecular Assemblies Inc. Modifizierte vorlagenunabhängige enzyme zur polydeoxynukleotidsynthese
WO2016071701A1 (en) 2014-11-07 2016-05-12 Kymab Limited Treatment of disease using ligand binding to targets of interest
US11085076B2 (en) 2015-09-28 2021-08-10 The Trustees Of Columbia University In The City Of New York Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
US11421264B2 (en) 2015-11-06 2022-08-23 IsoPlexis Corporation Thiol-containing cleave reagents and oxidative wash
KR102454782B1 (ko) * 2015-11-06 2022-10-13 퀴아젠 사이언시스, 엘엘씨 뉴클레오티드 유사체
CN109661232B (zh) * 2016-05-23 2023-03-03 纽约哥伦比亚大学董事会 核苷酸衍生物及其使用方法
US10704082B2 (en) 2016-09-15 2020-07-07 ArcherDX, Inc. Methods of nucleic acid sample preparation
EP3512965B1 (de) 2016-09-15 2024-03-13 ArcherDX, LLC Verfahren zur herstellung von nukleinsäuren zur analyse von zellfreier dna
AU2017355460B2 (en) 2016-11-02 2022-12-08 Archerdx, Llc Methods of nucleic acid sample preparation for immune repertoire sequencing
CN110506121A (zh) * 2016-11-04 2019-11-26 奇根科学有限责任公司 含硫羟基的切割试剂和氧化洗涤剂
EP3565820A1 (de) * 2017-01-06 2019-11-13 The Charles Stark Draper Laboratory, Inc. Optisch verifizierte polymersynthese
WO2018165207A1 (en) 2017-03-06 2018-09-13 Singular Genomic Systems, Inc. Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
US12018325B2 (en) 2017-03-28 2024-06-25 The Trustees Of Columbia University In The City Of New York 3′-O-modified nucleotide analogues with different cleavable linkers for attaching fluorescent labels to the base for DNA sequencing by synthesis
EP3545106B1 (de) 2017-08-01 2022-01-19 Helitec Limited Verfahren zur anreicherung und bestimmung von zielnukleotidsequenzen
US10844430B2 (en) 2018-01-24 2020-11-24 Qiagen Sciences, Llc DNA sequencing reaction additive
WO2019164977A1 (en) 2018-02-21 2019-08-29 Singular Genomics Systems, Inc. Fluorinated nucleotides and uses thereof
US12188086B2 (en) 2018-03-15 2025-01-07 The Trustees Of Columbia University In The City Of New York Nucleotide analogues and use thereof for nucleic acid sequencing and analysis preliminary class
US12145960B2 (en) 2018-10-25 2024-11-19 Singular Genomics Systems, Inc. Nucleotide analogues
US11970735B2 (en) 2019-01-08 2024-04-30 Singular Genomics Systems, Inc. Nucleotide cleavable linkers and uses thereof
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11795450B2 (en) 2019-09-06 2023-10-24 Microsoft Technology Licensing, Llc Array-based enzymatic oligonucleotide synthesis
EP4117682B1 (de) 2020-04-24 2025-06-04 Singular Genomics Systems, Inc. Modifizierte nukleotide und verwendungen davon
US11702683B2 (en) 2020-05-28 2023-07-18 Microsoft Technology Licensing, Llc De novo polynucleotide synthesis with substrate-bound polymerase
US11840715B2 (en) 2020-06-30 2023-12-12 Microsoft Technology Licensing, Llc Microelectrode array with a switchable hydrophilic surface
US20220307077A1 (en) 2021-03-24 2022-09-29 Ambry Genetics Corporation Conservative concurrent evaluation of dna modifications
US20220372468A1 (en) 2021-05-19 2022-11-24 Microsoft Technology Licensing, Llc Real-time detection of errors in oligonucleotide synthesis
IL309799A (en) 2021-07-20 2024-02-01 Regeneron Pharma Butyrophilin-2-like substances for the treatment of inflammatory disorders
US20230242571A1 (en) * 2022-02-02 2023-08-03 Singular Genomics Systems, Inc. Silicon containing modified nucleotide analogs

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962417A (en) * 1956-08-27 1960-11-29 Du Pont Nitroaryldisulfide pesticide
SE454781B (sv) 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
JP2541582B2 (ja) * 1987-09-29 1996-10-09 三井東圧化学株式会社 ポリチオ―ル
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
SE8801702D0 (sv) 1988-05-05 1988-05-05 Pharmacia Ab Sett vid bestemning av enzymatisk aktivitet
WO1991000868A1 (en) * 1989-07-07 1991-01-24 National Research Development Corporation Immobilised polynucleotides
US5216134A (en) 1989-10-23 1993-06-01 Wallac Oy Spectrofluorometric method and compounds that are of value for the method
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5571937A (en) * 1994-05-13 1996-11-05 Sloan-Kettering Institute For Cancer Research Complementary DNA and toxins
SE9500342D0 (sv) 1995-01-31 1995-01-31 Marek Kwiatkowski Novel chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
JPH08227149A (ja) * 1995-02-21 1996-09-03 Toray Ind Inc 水なし平版印刷版原版
SE9603171D0 (sv) 1996-08-30 1996-08-30 Marek Kwiatkowski Solid phase synthesis
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
US5837860A (en) * 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
SE9701783D0 (sv) 1997-05-14 1997-05-14 Marek Kwiatkowski In situ synthesis of oligonucleotides of inverse orientation
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US6309836B1 (en) * 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use

Also Published As

Publication number Publication date
US20040175726A1 (en) 2004-09-09
EP1218391B1 (de) 2007-04-11
AU7979200A (en) 2001-05-10
US6309836B1 (en) 2001-10-30
US7279563B2 (en) 2007-10-09
JP2003511386A (ja) 2003-03-25
CA2386221C (en) 2009-06-30
CA2386221A1 (en) 2001-04-12
EP1218391A1 (de) 2002-07-03
WO2001025247A1 (en) 2001-04-12
US20020015961A1 (en) 2002-02-07
ATE359289T1 (de) 2007-05-15
DE60034354T2 (de) 2007-12-20
US6639088B2 (en) 2003-10-28

Similar Documents

Publication Publication Date Title
DE60034354D1 (de) Verbindungen zum schutz von hydroxylgruppen und ihre anwendung
HK1046688A1 (zh) 喹唑啉化合物和含有喹唑啉化合物的藥物組合物
NO20021395D0 (no) Kinazolinderivater
BR0109922A (pt) Compostos quìmicos
SE0102439D0 (sv) New compounds
NO20013768D0 (no) Kjemiske forbindelser
DE69520880D1 (de) 9-deoxotaxan verbindungen
NO984470L (no) Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase
WO2002007677A3 (en) Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
SE8904306D0 (sv) Capsaicin derivatives
BR9912684A (pt) Composto de fórmula (i), composição farmacêutica compreendendo o composto, método, processo e seu uso
DE69729104D1 (de) Pharmazeutische zusammensetzungen enthaltend tyrphostine
BRPI0409069A (pt) compostos quìmicos
DE69903838D1 (de) Phosphoepoxide, verfahren zu deren herstellung und ihre verwendungen
CO5140099A1 (es) Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
DE60211500D1 (de) Metallkomplexe und deren therapeutische verwendungen
NZ514990A (en) Releasable linkage and compositions containing same
EA200001107A1 (ru) ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
TH52208A (th) อนุพันธ์ของ n-เฟนิแลมีด และ n-พิริดิแลมีด ต่าง ๆ ชนิดใหม่ วิธีการของการเตรียมอนุพันธ์เหล่านี้ และสารผสมเชิงเภสัชกรรมที่มีอนุพันธ์เหล่านี้อยู่ด้วย
TH32480A (de)
TH30776A (th) ขบวนการที่ใช้สำหรับเตรียมและใช้ตัวต่อต้านบราดิไคนินที่เป็นเฮเทอโรไซคลิก ซึ่งมีซัลเฟอร์
RU96105572A (ru) Способ стабилизации олинонуклеотидных дуплексов
BR9911929A (pt) Processos para preparar compostos, composto, e, usos de um processo e de um composto
TH34999A (de)
TH54361A3 (th) อนุพันธ์โครแมน

Legal Events

Date Code Title Description
8364 No opposition during term of opposition