DE60031133D1 - Verfahren zur darstellung von lh-rh-derivaten - Google Patents

Verfahren zur darstellung von lh-rh-derivaten

Info

Publication number: DE60031133D1
Authority: DE; Germany
Prior art keywords: derivatives; resin adsorbent; synthetic; treatment; impurities
Prior art date: 1999-06-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60031133T

Other languages

English (en)

Other versions

DE60031133T2 (de

Inventor

Yasuhiro Sasaki

Katsuji Shimizu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-30

Filing date

2000-06-29

Publication date

2006-11-16

2000-06-29 Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd

2006-11-16 Application granted granted Critical

2006-11-16 Publication of DE60031133D1 publication Critical patent/DE60031133D1/de

2007-04-12 Publication of DE60031133T2 publication Critical patent/DE60031133T2/de

2020-06-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 3
239000003463 adsorbent Substances 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000000113 methacrylic resin Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE60031133T 1999-06-30 2000-06-29 Verfahren zur darstellung von lh-rh-derivaten Expired - Lifetime DE60031133T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP18630799		1999-06-30
JP18630799		1999-06-30
PCT/JP2000/004277 WO2001002428A1 (en)	1999-06-30	2000-06-29	Process for the preparation of lh-rh derivatives

Publications (2)

Publication Number	Publication Date
DE60031133D1 true DE60031133D1 (de)	2006-11-16
DE60031133T2 DE60031133T2 (de)	2007-04-12

Family

ID=16186046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60031133T Expired - Lifetime DE60031133T2 (de)	1999-06-30	2000-06-29	Verfahren zur darstellung von lh-rh-derivaten

Country Status (7)

Country	Link
US (1)	US20050261195A1 (de)
EP (2)	EP1207167B1 (de)
AT (1)	ATE341562T1 (de)
AU (1)	AU5705500A (de)
CA (1)	CA2376763C (de)
DE (1)	DE60031133T2 (de)
WO (1)	WO2001002428A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2119725A1 (de) *	2005-05-03	2009-11-18	Novetide Ltd.	Verfahren zur Herstellung von Leuprolid
KR100722607B1 (ko)	2006-05-11	2007-05-28	주식회사 펩트론	분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
CN101195653B (zh) *	2006-12-08	2010-05-12	吉尔生化（上海）有限公司	亮丙瑞林的固液合成法
AU2008306141A1 (en) *	2007-09-11	2009-04-09	Mondobiotech Laboratories Ag	Thyrotropin releasing hormone for therapeutic applications
CN118047836A (zh) *	2024-01-19	2024-05-17	中肽生化有限公司	一种戈舍瑞林杂质e的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3816386A (en) *	1972-06-20	1974-06-11	Abbott Lab	Purification process for gn-rh
CS180644B2 (en) *	1973-09-29	1978-01-31	Takeda Chemical Industries Ltd	Process for preparing nonapeptides
US3997516A (en) *	1974-07-04	1976-12-14	Takeda Chemical Industries, Ltd.	Method for protecting guanidino group and restoring the same
CA1283072C (en) *	1986-12-01	1991-04-16	Timothy Durance	Process for the isolation and separation of lysozyme and avidin from eggwhite
DK0910575T3 (da) *	1996-06-21	2003-02-03	Takeda Chemical Industries Ltd	Fremgangsmåde til fremstilling af peptider
JP3020141B2 (ja) *	1996-10-07	2000-03-15	株式会社富士薬品	経鼻投与用製剤

2000
- 2000-06-29 WO PCT/JP2000/004277 patent/WO2001002428A1/ja not_active Ceased
- 2000-06-29 AT AT00942386T patent/ATE341562T1/de not_active IP Right Cessation
- 2000-06-29 EP EP00942386A patent/EP1207167B1/de not_active Expired - Lifetime
- 2000-06-29 DE DE60031133T patent/DE60031133T2/de not_active Expired - Lifetime
- 2000-06-29 CA CA002376763A patent/CA2376763C/en not_active Expired - Fee Related
- 2000-06-29 EP EP06002729A patent/EP1777232A1/de not_active Withdrawn
- 2000-06-29 AU AU57055/00A patent/AU5705500A/en not_active Abandoned
2005
- 2005-04-07 US US11/101,895 patent/US20050261195A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1207167B1 (de)	2006-10-04
CA2376763C (en)	2009-12-22
EP1777232A1 (de)	2007-04-25
DE60031133T2 (de)	2007-04-12
CA2376763A1 (en)	2001-01-11
AU5705500A (en)	2001-01-22
EP1207167A1 (de)	2002-05-22
EP1207167A4 (de)	2003-04-16
WO2001002428A1 (en)	2001-01-11
US20050261195A1 (en)	2005-11-24
ATE341562T1 (de)	2006-10-15

Similar Documents

Publication	Publication Date	Title
DE60230274D1 (de)	2009-01-22	Verfahren zur herstellung von l-aminosäuren durch enterobacteriaceae-stämmen mit verstärkter expression des pts-g
ATE306252T1 (de)	2005-10-15	Verfahren zur herstellung kristalliner partikel zur inhalation
DE59107901D1 (de)	1996-07-11	Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
DE60027695D1 (de)	2006-06-08	Verfahren zur herstellung von fibrinogen und fibronectin sowie proteinzusammesetzungen, welche damit herstellbar sind
DE69119234D1 (de)	1996-06-05	Verfahren zur herstellung von reiner hydroxyessigsäure
ATE424379T1 (de)	2009-03-15	Verfahren zur herstellung von gesamt- salvianolsäure
DE60038560D1 (de)	2008-05-21	Verfahren zur fermentativen Herstellung von L-Arginin
ATE256695T1 (de)	2004-01-15	Verfahren zur herstellung von pharmazeutisch annehmbaren salzen des (ss,rs)-s-adenosyl-l- menthionin
DE60031133D1 (de)	2006-11-16	Verfahren zur darstellung von lh-rh-derivaten
IL177286A0 (en)	2006-12-10	Albumin-purification method comprising a nanofiltration step, solution, and composition for therapeutic use containing same
ATE85927T1 (de)	1993-03-15	Verfahren zur herstellung enes raeumwerkzeugs.
ATE302749T1 (de)	2005-09-15	Verfahren zur herstellung von 5-aminosalicylsäure
DE69500481D1 (de)	1997-09-04	Verfahren zur Herstellung von N-Chloracetylglutamin
ATE316082T1 (de)	2006-02-15	Prozess zur herstellung von r(+)alpha-liponsäure
ATE395428T1 (de)	2008-05-15	Verfahren zur isolierung und reinigung von lipidezellwandkomponenten
ATE366723T1 (de)	2007-08-15	Verfahren zur herstellung von chinoloncarboxylat- derivaten
ATE272038T1 (de)	2004-08-15	Verfahren zur herstellung von 2-alkyl-3- chlorphenolen
JPS5275580A (en)	1977-06-24	Process for the preparation of feed
JPS5262207A (en)	1977-05-23	Purification process for chloroform
ATE281428T1 (de)	2004-11-15	Verfahren zur herstellung von methoxyimino- essigsäureamiden
DE59106495D1 (de)	1995-10-19	Verfahren zur herstellung von isopropylnaphthalin.
ATE123495T1 (de)	1995-06-15	Verfahren zur herstellung 2-chlor-1,7- dihydropurin-6-on und verfahren zu dessen reinigung.
DE50304371D1 (de)	2006-09-07	Technisches verfahren zur herstellung von tropenol
ATE338750T1 (de)	2006-09-15	Verfahren zur herstellung von chinolinderivaten
ATE317842T1 (de)	2006-03-15	Verfahren zur herstellung von 2-halo-6- nitrobenzoesäuren

Legal Events

Date	Code	Title	Description
2007-10-25	8364	No opposition during term of opposition