DE60028990D1 - Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten - Google Patents
Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituentenInfo
- Publication number
- DE60028990D1 DE60028990D1 DE60028990T DE60028990T DE60028990D1 DE 60028990 D1 DE60028990 D1 DE 60028990D1 DE 60028990 T DE60028990 T DE 60028990T DE 60028990 T DE60028990 T DE 60028990T DE 60028990 D1 DE60028990 D1 DE 60028990D1
- Authority
- DE
- Germany
- Prior art keywords
- piperazine
- preparation
- alkyl
- carboxylate
- substituted aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000007942 carboxylates Chemical class 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- -1 aliphatic carboxylate Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910001411 inorganic cation Inorganic materials 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US421514 | 1999-10-20 | ||
| US09/421,514 US6239277B1 (en) | 1999-10-20 | 1999-10-20 | Process for preparing piperazine-substituted aliphatic carboxylates |
| PCT/US2000/019625 WO2001029016A1 (en) | 1999-10-20 | 2000-07-19 | Process for preparing piperazine-substituted aliphatic carboxylates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60028990D1 true DE60028990D1 (de) | 2006-08-03 |
| DE60028990T2 DE60028990T2 (de) | 2007-02-01 |
Family
ID=23670848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60028990T Expired - Fee Related DE60028990T2 (de) | 1999-10-20 | 2000-07-19 | Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6239277B1 (de) |
| EP (1) | EP1222179B1 (de) |
| AT (1) | ATE330945T1 (de) |
| DE (1) | DE60028990T2 (de) |
| WO (1) | WO2001029016A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7297697B2 (en) * | 2002-03-27 | 2007-11-20 | Sun Pharmaceutical Industries Limited | 4-(diarylmethyl)-1-piperazinyl derivatives |
| WO2003104212A1 (en) * | 2002-06-05 | 2003-12-18 | Dr.Reddy's Laboratories Ltd. | A novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetic acid dihydrochloride (cetirizine dihydrochloride) |
| SI22489A (sl) * | 2007-03-12 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za pripravo levocetirizina in njegovih intermediatov |
| WO2008110586A2 (en) | 2007-03-12 | 2008-09-18 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
| WO2009150147A1 (en) * | 2008-06-11 | 2009-12-17 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
| WO2010046908A2 (en) | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| CN113861131B (zh) * | 2021-11-08 | 2024-04-19 | 深圳菲斯生物科技有限公司 | 一种西替利嗪杂质c的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
-
1999
- 1999-10-20 US US09/421,514 patent/US6239277B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 DE DE60028990T patent/DE60028990T2/de not_active Expired - Fee Related
- 2000-07-19 EP EP00947505A patent/EP1222179B1/de not_active Expired - Lifetime
- 2000-07-19 WO PCT/US2000/019625 patent/WO2001029016A1/en not_active Ceased
- 2000-07-19 AT AT00947505T patent/ATE330945T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60028990T2 (de) | 2007-02-01 |
| EP1222179B1 (de) | 2006-06-21 |
| US6239277B1 (en) | 2001-05-29 |
| EP1222179A1 (de) | 2002-07-17 |
| ATE330945T1 (de) | 2006-07-15 |
| EP1222179A4 (de) | 2003-01-02 |
| WO2001029016A1 (en) | 2001-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |