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DE60026407D1 - Verfahren zur Herstellung von Vitamin-D Analogen - Google Patents

Verfahren zur Herstellung von Vitamin-D Analogen

Info

Publication number
DE60026407D1
DE60026407D1 DE60026407T DE60026407T DE60026407D1 DE 60026407 D1 DE60026407 D1 DE 60026407D1 DE 60026407 T DE60026407 T DE 60026407T DE 60026407 T DE60026407 T DE 60026407T DE 60026407 D1 DE60026407 D1 DE 60026407D1
Authority
DE
Germany
Prior art keywords
formula
carbon
compound
vitamin
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026407T
Other languages
English (en)
Other versions
DE60026407T2 (de
Inventor
Andrzej Robert Daniewski
Marek Michal Kabat
Masami Okabe
Rouman Nikolaev Radinov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60026407D1 publication Critical patent/DE60026407D1/de
Application granted granted Critical
Publication of DE60026407T2 publication Critical patent/DE60026407T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/38Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60026407T 1999-08-23 2000-08-16 Verfahren zur Herstellung von Vitamin-D Analogen Expired - Lifetime DE60026407T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15037899P 1999-08-23 1999-08-23
US15022699P 1999-08-23 1999-08-23
US150378P 1999-08-23
US150226P 1999-08-23

Publications (2)

Publication Number Publication Date
DE60026407D1 true DE60026407D1 (de) 2006-05-04
DE60026407T2 DE60026407T2 (de) 2006-11-09

Family

ID=26847433

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026407T Expired - Lifetime DE60026407T2 (de) 1999-08-23 2000-08-16 Verfahren zur Herstellung von Vitamin-D Analogen

Country Status (9)

Country Link
EP (1) EP1078931B1 (de)
JP (1) JP3517391B2 (de)
KR (1) KR100369881B1 (de)
CN (2) CN1179938C (de)
AT (1) ATE319722T1 (de)
CA (1) CA2316157C (de)
DE (1) DE60026407T2 (de)
ES (1) ES2258432T3 (de)
MX (1) MXPA00008175A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4811547B2 (ja) * 2000-10-24 2011-11-09 史衛 佐藤 光学活性シクロヘキセン化合物の製造法及びこの製造に用いる光学活性シクロヘキセン誘導体
JP6421757B2 (ja) * 2013-09-25 2018-11-14 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
CN112724060B (zh) * 2021-01-15 2022-10-21 常州博海威医药科技股份有限公司 前列腺素的新制备方法以及中间体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3030157B2 (ja) * 1991-03-13 2000-04-10 株式会社クラレ シクロヘキサントリオール誘導体

Also Published As

Publication number Publication date
EP1078931A3 (de) 2003-04-16
ATE319722T1 (de) 2006-03-15
CA2316157C (en) 2004-11-23
JP2001122882A (ja) 2001-05-08
KR20010071114A (ko) 2001-07-28
EP1078931B1 (de) 2006-03-08
EP1078931A2 (de) 2001-02-28
CN1554650A (zh) 2004-12-15
ES2258432T3 (es) 2006-09-01
CN1287115A (zh) 2001-03-14
MXPA00008175A (es) 2002-08-06
JP3517391B2 (ja) 2004-04-12
CN1269808C (zh) 2006-08-16
CA2316157A1 (en) 2001-02-23
CN1179938C (zh) 2004-12-15
KR100369881B1 (ko) 2003-01-30
DE60026407T2 (de) 2006-11-09

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Legal Events

Date Code Title Description
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