DE60024471D1 - Benzopyran derivate - Google Patents
Benzopyran derivateInfo
- Publication number
- DE60024471D1 DE60024471D1 DE60024471T DE60024471T DE60024471D1 DE 60024471 D1 DE60024471 D1 DE 60024471D1 DE 60024471 T DE60024471 T DE 60024471T DE 60024471 T DE60024471 T DE 60024471T DE 60024471 D1 DE60024471 D1 DE 60024471D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- hydrogen atom
- alkyl group
- substituted
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- -1 (substituted)phenyl group Chemical group 0.000 abstract 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000036747 functional refractory period Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26445599 | 1999-09-17 | ||
| JP26445599 | 1999-09-17 | ||
| PCT/JP2000/006323 WO2001021610A1 (en) | 1999-09-17 | 2000-09-14 | Benzopyran derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60024471D1 true DE60024471D1 (de) | 2006-01-05 |
| DE60024471T2 DE60024471T2 (de) | 2006-08-03 |
Family
ID=17403453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60024471T Expired - Lifetime DE60024471T2 (de) | 1999-09-17 | 2000-09-14 | Benzopyranderivate |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6589983B1 (de) |
| EP (1) | EP1212314B1 (de) |
| KR (1) | KR100766676B1 (de) |
| CN (1) | CN1167697C (de) |
| AT (1) | ATE311378T1 (de) |
| AU (1) | AU766935B2 (de) |
| CA (1) | CA2383583C (de) |
| CZ (1) | CZ2002802A3 (de) |
| DE (1) | DE60024471T2 (de) |
| HK (1) | HK1047106B (de) |
| HU (1) | HUP0202690A3 (de) |
| IL (2) | IL147968A0 (de) |
| NO (1) | NO328013B1 (de) |
| NZ (1) | NZ517404A (de) |
| RU (1) | RU2234502C2 (de) |
| SK (1) | SK3292002A3 (de) |
| WO (1) | WO2001021610A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW589305B (en) * | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| FI20011507A0 (fi) | 2001-07-10 | 2001-07-10 | Orion Corp | Uusia yhdisteitä |
| BR0213094A (pt) * | 2001-10-04 | 2004-10-13 | Wyeth Corp | Derivados de cromano como ligandos de 5-hidroxi-triptamina-6 |
| SI1535918T1 (sl) * | 2002-08-29 | 2011-01-31 | Nissan Chemical Ind Ltd | Postopek za proizvodnjo aminobenzopiranske spojine |
| FI20030030A0 (fi) | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| TWI346112B (en) | 2004-02-25 | 2011-08-01 | Nissan Chemical Ind Ltd | Benzopyran compound |
| PT1732929E (pt) | 2004-03-23 | 2010-12-21 | Nissan Chemical Ind Ltd | Composto de benzopirano tricíclico enquanto agentes antiarrítmicos |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| JP4738418B2 (ja) * | 2004-12-21 | 2011-08-03 | エフ．ホフマン−ラ ロシュ アーゲー | クロマン誘導体及びｃｎｓ障害の処置におけるその使用 |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| WO2007105658A1 (ja) * | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | 光学活性クロメンオキシド化合物の製造方法 |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| AU2011274369A1 (en) * | 2010-07-02 | 2012-12-06 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| WO2013072693A1 (en) | 2011-11-15 | 2013-05-23 | Xention Limited | Thieno [2, 3 - c] pyrazoles for use as potassium channel inhibitors |
| US20150045305A1 (en) | 2012-01-27 | 2015-02-12 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| WO2020138428A1 (ja) | 2018-12-28 | 2020-07-02 | 国立大学法人大阪大学 | 遺伝性徐脈性不整脈治療薬 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9005318D0 (en) * | 1990-03-09 | 1990-05-02 | Isis Innovation | Antiarrhythmic agents |
| AU651105B2 (en) * | 1990-06-18 | 1994-07-14 | E.R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
| GB9301611D0 (en) * | 1993-08-04 | 1993-08-04 | Parisella Gerald | Dexterity game |
| HUP9902456A3 (en) | 1996-07-26 | 2002-04-29 | Nissan Chemical Ind Ltd | Chroman derivatives |
-
2000
- 2000-09-14 IL IL14796800A patent/IL147968A0/xx active IP Right Grant
- 2000-09-14 WO PCT/JP2000/006323 patent/WO2001021610A1/en not_active Ceased
- 2000-09-14 RU RU2002110115/04A patent/RU2234502C2/ru not_active IP Right Cessation
- 2000-09-14 CZ CZ2002802A patent/CZ2002802A3/cs unknown
- 2000-09-14 NZ NZ517404A patent/NZ517404A/xx unknown
- 2000-09-14 US US10/048,026 patent/US6589983B1/en not_active Expired - Fee Related
- 2000-09-14 DE DE60024471T patent/DE60024471T2/de not_active Expired - Lifetime
- 2000-09-14 AU AU73143/00A patent/AU766935B2/en not_active Ceased
- 2000-09-14 HK HK02108750.1A patent/HK1047106B/en not_active IP Right Cessation
- 2000-09-14 CN CNB008129509A patent/CN1167697C/zh not_active Expired - Fee Related
- 2000-09-14 HU HU0202690A patent/HUP0202690A3/hu unknown
- 2000-09-14 CA CA002383583A patent/CA2383583C/en not_active Expired - Fee Related
- 2000-09-14 AT AT00961032T patent/ATE311378T1/de not_active IP Right Cessation
- 2000-09-14 SK SK329-2002A patent/SK3292002A3/sk unknown
- 2000-09-14 KR KR1020027003510A patent/KR100766676B1/ko not_active Expired - Fee Related
- 2000-09-14 EP EP00961032A patent/EP1212314B1/de not_active Expired - Lifetime
-
2002
- 2002-02-03 IL IL147968A patent/IL147968A/en not_active IP Right Cessation
- 2002-03-15 NO NO20021294A patent/NO328013B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2383583C (en) | 2009-04-07 |
| NZ517404A (en) | 2003-01-31 |
| AU766935B2 (en) | 2003-10-23 |
| AU7314300A (en) | 2001-04-24 |
| US6589983B1 (en) | 2003-07-08 |
| EP1212314A1 (de) | 2002-06-12 |
| RU2234502C2 (ru) | 2004-08-20 |
| CN1374957A (zh) | 2002-10-16 |
| IL147968A0 (en) | 2002-09-12 |
| EP1212314B1 (de) | 2005-11-30 |
| CZ2002802A3 (cs) | 2003-02-12 |
| NO20021294L (no) | 2002-03-15 |
| HUP0202690A2 (hu) | 2002-12-28 |
| CN1167697C (zh) | 2004-09-22 |
| KR100766676B1 (ko) | 2007-10-15 |
| IL147968A (en) | 2006-04-10 |
| NO20021294D0 (no) | 2002-03-15 |
| CA2383583A1 (en) | 2001-03-29 |
| HK1047106B (en) | 2006-04-28 |
| SK3292002A3 (en) | 2003-04-01 |
| DE60024471T2 (de) | 2006-08-03 |
| KR20020068505A (ko) | 2002-08-27 |
| HK1047106A1 (en) | 2003-02-07 |
| NO328013B1 (no) | 2009-11-09 |
| ATE311378T1 (de) | 2005-12-15 |
| HUP0202690A3 (en) | 2005-02-28 |
| WO2001021610A1 (en) | 2001-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |