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DE60023138D1 - Verwendung eines biologisch abbaubaren Polymers - Google Patents

Verwendung eines biologisch abbaubaren Polymers

Info

Publication number
DE60023138D1
DE60023138D1 DE60023138T DE60023138T DE60023138D1 DE 60023138 D1 DE60023138 D1 DE 60023138D1 DE 60023138 T DE60023138 T DE 60023138T DE 60023138 T DE60023138 T DE 60023138T DE 60023138 D1 DE60023138 D1 DE 60023138D1
Authority
DE
Germany
Prior art keywords
biodegradable polymer
solid tumor
phosphoester
mammal
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60023138T
Other languages
English (en)
Other versions
DE60023138T2 (de
Inventor
Wenbin Dang
I Garver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Inc
Original Assignee
Guilford Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc filed Critical Guilford Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60023138D1 publication Critical patent/DE60023138D1/de
Publication of DE60023138T2 publication Critical patent/DE60023138T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE60023138T 1999-03-26 2000-03-20 Verfahren und Zusammensetzung zur Behandlung von soliden Tumoren Expired - Lifetime DE60023138T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US276866 1999-03-26
US09/276,866 US6537585B1 (en) 1999-03-26 1999-03-26 Methods and compositions for treating solid tumors
PCT/US2000/007304 WO2000057852A2 (en) 1999-03-26 2000-03-20 Methods and compositions for treating solid tumors

Publications (2)

Publication Number Publication Date
DE60023138D1 true DE60023138D1 (de) 2006-02-23
DE60023138T2 DE60023138T2 (de) 2006-08-17

Family

ID=23058398

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023138T Expired - Lifetime DE60023138T2 (de) 1999-03-26 2000-03-20 Verfahren und Zusammensetzung zur Behandlung von soliden Tumoren

Country Status (17)

Country Link
US (2) US6537585B1 (de)
EP (1) EP1185249B1 (de)
JP (2) JP2002540137A (de)
KR (1) KR20010111578A (de)
CN (1) CN1367684A (de)
AT (1) ATE306251T1 (de)
AU (1) AU778279B2 (de)
BR (1) BR0009213A (de)
CA (1) CA2368621C (de)
CZ (1) CZ20013260A3 (de)
DE (1) DE60023138T2 (de)
HU (1) HUP0201436A3 (de)
IL (1) IL145492A0 (de)
NO (1) NO20014662L (de)
PL (1) PL351280A1 (de)
TR (1) TR200102801T2 (de)
WO (1) WO2000057852A2 (de)

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US20020045668A1 (en) * 2000-07-17 2002-04-18 Wenbin Dang Compositions for sustained release of analgesic agents, and methods of making and using the same
WO2002030472A2 (en) * 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same
US20020141966A1 (en) * 2000-11-16 2002-10-03 Wenbin Dang Compositions for treatment of malignant effusions, and methods of making and using the same
US20020081339A1 (en) * 2000-12-22 2002-06-27 Philippe Menei Treatment of inoperable tumors by stereotactic injection of microspheres
WO2002092667A1 (en) * 2001-05-14 2002-11-21 Johns Hopkins Singapore Pte Ltd. Biodegradable polyphosphates for controlled release of bioactive substances
WO2003000776A1 (en) * 2001-05-14 2003-01-03 Johns Hopkins Singapore Pte Ltd Biodegradable polyphosphoramidates for controlled release of bioactive substances
AU2002354957A1 (en) * 2001-07-19 2003-03-03 Guilford Pharmaceuticals, Inc. Biocompatible polymer containing composition for treatment of prostate cancers
US20030134892A1 (en) * 2001-07-19 2003-07-17 Wenbin Dang Compositions for treatment of head and neck cancers, and methods of making and using the same
US20050238616A1 (en) * 2002-01-09 2005-10-27 Guilford Pharmaceuticals, Inc. Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
AU2003216424A1 (en) * 2002-02-25 2003-10-08 Guilford Pharmaceuticals, Inc. Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
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US8735394B2 (en) * 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
ES2556974T3 (es) * 2005-08-12 2016-01-21 Jiang Liu Dispositivos para la orientación al sistema linfático
GB0525864D0 (en) * 2005-12-20 2006-02-01 Novartis Ag Organic compounds
EP3047860B1 (de) 2006-07-20 2024-08-28 OrbusNeich Medical Pte. Ltd. Bioresorbierbare polymerzusammensetzung für eine medizinische vorrichtung
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
CN101631513B (zh) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
CN101390828B (zh) * 2007-02-12 2010-06-09 济南康泉医药科技有限公司 同载抗代谢类药物和增效剂的抗癌组合物
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
EA022890B1 (ru) 2009-05-29 2016-03-31 Сидекс Фармасьютикалз, Инк. Инъецируемые композиции мелфалана, содержащие производное циклодекстрина, и способы их применения
ES2362525B8 (es) 2009-10-08 2013-01-03 Azurebio, S.L. Formulación de medicamentos en forma de agujas percutaneas penetrantes.
TWI438009B (zh) * 2010-02-19 2014-05-21 Teikoku Pharma Usa Inc 紫杉烷前－乳劑調配物及其製造與使用之方法
KR20180050426A (ko) 2010-03-29 2018-05-14 아브락시스 바이오사이언스, 엘엘씨 치료제의 약물 전달 및 유효성 향상 방법
KR101894689B1 (ko) 2010-03-29 2018-09-04 아브락시스 바이오사이언스, 엘엘씨 암의 치료 방법
SG185389A1 (en) 2010-05-03 2012-12-28 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
CA2801645A1 (en) 2010-06-04 2011-12-08 Abraxis Bioscience, Llc Use of nanoparticules comprising a taxane and an albumin in the treatment of pancreatic cancer
EP2897620B1 (de) 2012-09-21 2020-07-22 Intensity Therapeutics, Inc Verfahren zur behandlung von karzinomen
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
US9545447B2 (en) * 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
CA2988132C (en) 2015-06-04 2021-04-27 Crititech, Inc. Taxane particles and their use
BR112018069628A2 (pt) 2016-04-04 2019-02-12 Crititech, Inc. métodos para tratamento de tumor sólido
CA3063420A1 (en) 2017-06-09 2018-12-13 Crititech, Inc. Treatment of epithelial cysts by intracystic injection of antineoplastic particles
CA3063436A1 (en) 2017-06-14 2018-12-20 Crititech, Inc. Methods for treating lung disorders
BR112020005814A2 (pt) 2017-10-03 2020-09-24 Crititech, Inc. administração local de partículas antineoplásicas em combinação com administração sistêmica de agentes imunoterapêuticos para o tratamento de câncer
WO2020072090A1 (en) * 2018-10-03 2020-04-09 Crititech, Inc. Use of antineoplastic agents to stimulate the immune system for production of tertiary lymphoid structures (tls)
CA3112201A1 (en) 2018-10-16 2020-04-23 US Nano Food & Drug INC Intratumor injection formulation
US11752165B2 (en) 2020-04-13 2023-09-12 US Nano Food & Drug, Inc Basic chemotherapeutic intratumour injection formulation
GB2623319A (en) 2022-10-11 2024-04-17 Af Chempharm Ltd Method of synthesis of chloro-oxo-dioxaphospholane oxides and derivates

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US20020045668A1 (en) 2000-07-17 2002-04-18 Wenbin Dang Compositions for sustained release of analgesic agents, and methods of making and using the same
WO2002030472A2 (en) 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same
US20030134892A1 (en) 2001-07-19 2003-07-17 Wenbin Dang Compositions for treatment of head and neck cancers, and methods of making and using the same
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Also Published As

Publication number Publication date
NO20014662L (no) 2001-11-20
JP2002540137A (ja) 2002-11-26
KR20010111578A (ko) 2001-12-19
IL145492A0 (en) 2002-06-30
HUP0201436A2 (en) 2002-09-28
EP1185249B1 (de) 2005-10-12
NO20014662D0 (no) 2001-09-25
WO2000057852A2 (en) 2000-10-05
AU3762500A (en) 2000-10-16
CN1367684A (zh) 2002-09-04
EP1185249A2 (de) 2002-03-13
US6537585B1 (en) 2003-03-25
US7101568B2 (en) 2006-09-05
DE60023138T2 (de) 2006-08-17
CZ20013260A3 (cs) 2002-01-16
AU778279B2 (en) 2004-11-25
BR0009213A (pt) 2002-04-16
TR200102801T2 (tr) 2002-04-22
JP2011219483A (ja) 2011-11-04
WO2000057852A3 (en) 2001-02-15
ATE306251T1 (de) 2005-10-15
US20030203033A1 (en) 2003-10-30
CA2368621C (en) 2010-05-25
CA2368621A1 (en) 2000-10-05
HUP0201436A3 (en) 2003-04-28
PL351280A1 (en) 2003-04-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MGI GP, INC. (N.D.GES.D. STAATES DELAWARE), BA, US

8327 Change in the person/name/address of the patent owner

Owner name: EISAI CORPORATION OF NORTH AMERICA, WOODCLIFF , US

8327 Change in the person/name/address of the patent owner

Owner name: EISAI INC., WOODCLIFF LAKE, N.J., US