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DE60015594D1 - Imidazolderivate und deren verwendung als raf kinase inhibitoren - Google Patents

Imidazolderivate und deren verwendung als raf kinase inhibitoren

Info

Publication number
DE60015594D1
DE60015594D1 DE60015594T DE60015594T DE60015594D1 DE 60015594 D1 DE60015594 D1 DE 60015594D1 DE 60015594 T DE60015594 T DE 60015594T DE 60015594 T DE60015594 T DE 60015594T DE 60015594 D1 DE60015594 D1 DE 60015594D1
Authority
DE
Germany
Prior art keywords
kinase inhibitors
imidazole derivatives
raf kinase
occurred
excessive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60015594T
Other languages
English (en)
Other versions
DE60015594T2 (de
Inventor
David Dean
Peter Lovell
Andrew Takle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE60015594D1 publication Critical patent/DE60015594D1/de
Application granted granted Critical
Publication of DE60015594T2 publication Critical patent/DE60015594T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60015594T 1999-11-22 2000-11-20 Imidazolderivate und deren verwendung als raf kinase inhibitoren Expired - Fee Related DE60015594T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US16689599P 1999-11-22 1999-11-22
US16681499P 1999-11-22 1999-11-22
US16688599P 1999-11-22 1999-11-22
US16688699P 1999-11-22 1999-11-22
US166885P 1999-11-22
US166895P 1999-11-22
US166814P 1999-11-22
US166886P 1999-11-22
PCT/GB2000/004413 WO2001038324A2 (en) 1999-11-22 2000-11-20 Imidazole derivatives and their use as raf kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60015594D1 true DE60015594D1 (de) 2004-12-09
DE60015594T2 DE60015594T2 (de) 2005-10-27

Family

ID=27496721

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60015594T Expired - Fee Related DE60015594T2 (de) 1999-11-22 2000-11-20 Imidazolderivate und deren verwendung als raf kinase inhibitoren
DE60037597T Expired - Fee Related DE60037597T2 (de) 1999-11-22 2000-11-20 Imidazol- Derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60037597T Expired - Fee Related DE60037597T2 (de) 1999-11-22 2000-11-20 Imidazol- Derivate

Country Status (21)

Country Link
US (3) US7026336B1 (de)
EP (2) EP1232153B1 (de)
JP (2) JP2003514860A (de)
KR (1) KR20020050294A (de)
CN (1) CN1543346A (de)
AT (2) ATE281451T1 (de)
AU (2) AU1623601A (de)
BR (1) BR0015532A (de)
CA (1) CA2395564A1 (de)
CZ (1) CZ20021746A3 (de)
DE (2) DE60015594T2 (de)
ES (2) ES2298165T3 (de)
HK (1) HK1050190A1 (de)
HU (1) HUP0203403A3 (de)
IL (2) IL149150A0 (de)
MX (1) MXPA02005106A (de)
NO (1) NO20022318L (de)
NZ (1) NZ518032A (de)
PL (1) PL355912A1 (de)
TR (1) TR200201364T2 (de)
WO (2) WO2001038324A2 (de)

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Also Published As

Publication number Publication date
CN1543346A (zh) 2004-11-03
ATE382044T1 (de) 2008-01-15
HUP0203403A3 (en) 2004-01-28
NO20022318D0 (no) 2002-05-15
ATE281451T1 (de) 2004-11-15
JP2003514906A (ja) 2003-04-22
WO2001038324A2 (en) 2001-05-31
JP2003514860A (ja) 2003-04-22
IL149150A0 (en) 2002-12-01
DE60037597T2 (de) 2008-12-11
WO2001037835A1 (en) 2001-05-31
AU1529901A (en) 2001-06-04
EP1232153A2 (de) 2002-08-21
WO2001038324A3 (en) 2002-05-10
IL149150A (en) 2007-02-11
US20070010534A1 (en) 2007-01-11
KR20020050294A (ko) 2002-06-26
CA2395564A1 (en) 2001-05-31
PL355912A1 (en) 2004-05-31
EP1233769A4 (de) 2004-12-29
AU1623601A (en) 2001-06-04
MXPA02005106A (es) 2002-11-07
ES2298165T3 (es) 2008-05-16
HUP0203403A2 (hu) 2003-02-28
EP1233769A1 (de) 2002-08-28
US7026336B1 (en) 2006-04-11
DE60015594T2 (de) 2005-10-27
EP1233769B1 (de) 2007-12-26
ES2228629T3 (es) 2005-04-16
CZ20021746A3 (cs) 2002-10-16
NO20022318L (no) 2002-05-15
HK1050190A1 (zh) 2003-06-13
TR200201364T2 (tr) 2002-10-21
US7189745B1 (en) 2007-03-13
NZ518032A (en) 2004-02-27
DE60037597D1 (de) 2008-02-07
EP1232153B1 (de) 2004-11-03
BR0015532A (pt) 2002-06-25

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