DE60011062D1 - Verfahren zur herstellung von selbstvernetzten hyaluronsäuren und deren derivaten mittels superkritischer anti-lösungsmittel - Google Patents
Verfahren zur herstellung von selbstvernetzten hyaluronsäuren und deren derivaten mittels superkritischer anti-lösungsmittelInfo
- Publication number
- DE60011062D1 DE60011062D1 DE60011062T DE60011062T DE60011062D1 DE 60011062 D1 DE60011062 D1 DE 60011062D1 DE 60011062 T DE60011062 T DE 60011062T DE 60011062 T DE60011062 T DE 60011062T DE 60011062 D1 DE60011062 D1 DE 60011062D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- solvents
- self
- production
- cross
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012296 anti-solvent Substances 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999PD000070A IT1306643B1 (it) | 1999-04-08 | 1999-04-08 | Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica |
| PCT/EP2000/002814 WO2000061640A1 (en) | 1999-04-08 | 2000-03-30 | Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60011062D1 true DE60011062D1 (de) | 2004-07-01 |
Family
ID=11392546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60011062T Expired - Lifetime DE60011062D1 (de) | 1999-04-08 | 2000-03-30 | Verfahren zur herstellung von selbstvernetzten hyaluronsäuren und deren derivaten mittels superkritischer anti-lösungsmittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6552184B1 (de) |
| EP (1) | EP1165619B1 (de) |
| JP (1) | JP2002542316A (de) |
| AT (1) | ATE267843T1 (de) |
| AU (1) | AU769657B2 (de) |
| CA (1) | CA2369275C (de) |
| DE (1) | DE60011062D1 (de) |
| IT (1) | IT1306643B1 (de) |
| WO (1) | WO2000061640A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2295005T3 (es) | 1999-01-13 | 2008-04-16 | Alchemia Oncology Pty Limited | Uso de hialuronano para la preparacion de un medicamento para la mejora de la eficacia de farmacos citotoxicos. |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| WO2003018062A1 (en) * | 2001-08-27 | 2003-03-06 | Meditech Research Limited | Improved therapeutic protocols |
| US8937052B2 (en) | 2005-07-27 | 2015-01-20 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| EA013877B1 (ru) | 2005-09-07 | 2010-08-30 | Алкемиа Онколоджи Пти Лимитед | Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения |
| EP1942117A1 (de) * | 2006-12-29 | 2008-07-09 | Sigea S.R.L. | Derivate aus Carboxypolysacchariden |
| EP2209814B1 (de) * | 2007-11-13 | 2017-01-25 | Bio-Technology General (Israel) Ltd. | Verfahren zur sterilisation durch filtration in verdünnter lösung für viskoelastische biopolymere |
| WO2020016820A1 (en) | 2018-07-18 | 2020-01-23 | Bio-Technology General (Israel) Ltd. | Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| EP0817620B1 (de) | 1995-03-28 | 2002-01-30 | Fidia Advanced Biopolymers, S.R.L. | Nanosphären mit einem biokompatiblen polysaccharid |
| WO1997031691A1 (en) * | 1996-03-01 | 1997-09-04 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
| IT1287698B1 (it) * | 1996-08-29 | 1998-08-18 | Fidia Advanced Biopolymers Srl | Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico |
-
1999
- 1999-04-08 IT IT1999PD000070A patent/IT1306643B1/it active
-
2000
- 2000-03-30 WO PCT/EP2000/002814 patent/WO2000061640A1/en not_active Ceased
- 2000-03-30 DE DE60011062T patent/DE60011062D1/de not_active Expired - Lifetime
- 2000-03-30 CA CA002369275A patent/CA2369275C/en not_active Expired - Fee Related
- 2000-03-30 AT AT00929332T patent/ATE267843T1/de not_active IP Right Cessation
- 2000-03-30 US US09/958,147 patent/US6552184B1/en not_active Expired - Fee Related
- 2000-03-30 AU AU47459/00A patent/AU769657B2/en not_active Ceased
- 2000-03-30 JP JP2000611580A patent/JP2002542316A/ja active Pending
- 2000-03-30 EP EP00929332A patent/EP1165619B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6552184B1 (en) | 2003-04-22 |
| IT1306643B1 (it) | 2001-10-02 |
| AU4745900A (en) | 2000-11-14 |
| ATE267843T1 (de) | 2004-06-15 |
| CA2369275A1 (en) | 2000-10-19 |
| AU769657B2 (en) | 2004-01-29 |
| EP1165619A1 (de) | 2002-01-02 |
| WO2000061640A1 (en) | 2000-10-19 |
| ITPD990070A1 (it) | 2000-10-08 |
| CA2369275C (en) | 2009-02-03 |
| EP1165619B1 (de) | 2004-05-26 |
| JP2002542316A (ja) | 2002-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |