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DE60010049D1 - Phenylalaninolderivate - Google Patents

Phenylalaninolderivate

Info

Publication number
DE60010049D1
DE60010049D1 DE60010049T DE60010049T DE60010049D1 DE 60010049 D1 DE60010049 D1 DE 60010049D1 DE 60010049 T DE60010049 T DE 60010049T DE 60010049 T DE60010049 T DE 60010049T DE 60010049 D1 DE60010049 D1 DE 60010049D1
Authority
DE
Germany
Prior art keywords
alkyl
lower alkyl
alkanoyl
aryl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60010049T
Other languages
English (en)
Other versions
DE60010049T2 (de
Inventor
Achytharao Sidduri
Wright Tilley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60010049D1 publication Critical patent/DE60010049D1/de
Publication of DE60010049T2 publication Critical patent/DE60010049T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
DE60010049T 1999-02-18 2000-02-12 Phenylalaninolderivate Expired - Lifetime DE60010049T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12049899P 1999-02-18 1999-02-18
US120498P 1999-02-18
PCT/EP2000/001168 WO2000048988A1 (en) 1999-02-18 2000-02-12 Phenylalaninol derivatives

Publications (2)

Publication Number Publication Date
DE60010049D1 true DE60010049D1 (de) 2004-05-27
DE60010049T2 DE60010049T2 (de) 2005-03-31

Family

ID=22390691

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60010049T Expired - Lifetime DE60010049T2 (de) 1999-02-18 2000-02-12 Phenylalaninolderivate

Country Status (28)

Country Link
US (1) US6420600B1 (de)
EP (1) EP1154987B1 (de)
JP (1) JP2002537283A (de)
KR (1) KR100636458B1 (de)
CN (1) CN1213020C (de)
AT (1) ATE264835T1 (de)
AU (1) AU771938B2 (de)
BR (1) BR0008368A (de)
CA (1) CA2362833C (de)
CZ (1) CZ20012984A3 (de)
DE (1) DE60010049T2 (de)
DK (1) DK1154987T3 (de)
ES (1) ES2218116T3 (de)
HR (1) HRP20010594B1 (de)
HU (1) HUP0200343A3 (de)
ID (1) ID30057A (de)
IL (2) IL144641A0 (de)
MA (1) MA26772A1 (de)
MX (1) MXPA01008178A (de)
NO (1) NO20013946L (de)
PL (1) PL349463A1 (de)
PT (1) PT1154987E (de)
RU (1) RU2238265C2 (de)
SI (1) SI1154987T1 (de)
TR (1) TR200102395T2 (de)
WO (1) WO2000048988A1 (de)
YU (1) YU58601A (de)
ZA (1) ZA200106075B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
PT1265606E (pt) * 1999-08-13 2007-01-31 Biogen Idec Inc Inibidores da adesão celular
US6380387B1 (en) 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
US6388084B1 (en) 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
JP2006528988A (ja) 2003-05-20 2006-12-28 ジェネンテック・インコーポレーテッド アルファ−4インテグリンのチオカルバメート阻害剤
WO2006081986A1 (en) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Bambuterol and integrin inhibitor combination
WO2006094640A2 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Roflumilast and integrin inhibitor combination and method of treatment
MX2008000971A (es) * 2005-07-19 2008-03-27 Daiichi Sankyo Co Ltd Derivado de propanamida sustituida y composicion farmaceutica que comprende al mismo.
IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE584914A (de) 1958-11-24
US3527793A (en) 1967-08-18 1970-09-08 Bristol Myers Co Phenylglycine derivatives
SU961297A1 (ru) * 1981-02-16 1990-12-07 Институт биохимии АН ЛитССР Этиловый эфир N @ ,О-дифенилацетил-трео-DL-фенилсерина, про вл ющий противовоспалительное действие
IT1190378B (it) 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US5039805A (en) 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
EP0767790B1 (de) 1994-06-20 2001-12-12 Takeda Chemical Industries, Ltd. Kondensierte imidazolderivate, ihre herstellung und verwendung
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US5804595A (en) 1995-12-05 1998-09-08 Regents Of The University Of Minnesota Kappa opioid receptor agonists
DK0891325T3 (da) * 1996-03-29 2002-05-21 Searle & Co Para-substituerede phenylpropansyrederivater som integrinantagonister
CA2250464A1 (en) 1996-03-29 1997-10-09 G.D. Searle & Co. Meta-substituted phenylene derivatives and their use as alphavbeta3 integrin antagonists or inhibitors
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
EP1001764A4 (de) * 1997-05-29 2005-08-24 Merck & Co Inc Heterozyklische amide als zelladhäsionshemmern
BR9811988A (pt) * 1997-08-22 2000-09-05 Hoffmann La Roche Derivados de n-alcanoilfenilalanina
DE69824183T2 (de) * 1997-08-22 2005-04-21 Hoffmann La Roche N-alkanoylphenylalaninderivate
ATE273273T1 (de) 1998-02-26 2004-08-15 Celltech Therapeutics Ltd Phenylalaninderivate als inhibitoren von alpha4 integrinen
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds

Also Published As

Publication number Publication date
CN1213020C (zh) 2005-08-03
HRP20010594B1 (en) 2006-02-28
KR100636458B1 (ko) 2006-10-18
PT1154987E (pt) 2004-08-31
ES2218116T3 (es) 2004-11-16
HK1043589A1 (en) 2002-09-20
AU2548600A (en) 2000-09-04
SI1154987T1 (en) 2004-08-31
CA2362833A1 (en) 2000-08-24
PL349463A1 (en) 2002-07-29
DE60010049T2 (de) 2005-03-31
DK1154987T3 (da) 2004-08-09
WO2000048988A1 (en) 2000-08-24
JP2002537283A (ja) 2002-11-05
AU771938B2 (en) 2004-04-08
RU2238265C2 (ru) 2004-10-20
ATE264835T1 (de) 2004-05-15
BR0008368A (pt) 2001-11-06
EP1154987B1 (de) 2004-04-21
IL144641A (en) 2006-09-05
TR200102395T2 (tr) 2001-12-21
HUP0200343A2 (en) 2002-06-29
EP1154987A1 (de) 2001-11-21
ID30057A (id) 2001-11-01
HRP20010594A2 (en) 2002-08-31
NO20013946D0 (no) 2001-08-14
KR20010102260A (ko) 2001-11-15
CA2362833C (en) 2009-04-07
US6420600B1 (en) 2002-07-16
YU58601A (sh) 2004-05-12
MA26772A1 (fr) 2004-12-20
MXPA01008178A (es) 2002-03-13
IL144641A0 (en) 2002-05-23
ZA200106075B (en) 2002-10-24
CZ20012984A3 (cs) 2002-02-13
HUP0200343A3 (en) 2005-04-28
CN1340043A (zh) 2002-03-13
NO20013946L (no) 2001-08-14

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Legal Events

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