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DE60009911D1 - Aminothiazolderivate und ihre verwendung als crf-rezeptor-liganden - Google Patents

Aminothiazolderivate und ihre verwendung als crf-rezeptor-liganden

Info

Publication number
DE60009911D1
DE60009911D1 DE60009911T DE60009911T DE60009911D1 DE 60009911 D1 DE60009911 D1 DE 60009911D1 DE 60009911 T DE60009911 T DE 60009911T DE 60009911 T DE60009911 T DE 60009911T DE 60009911 D1 DE60009911 D1 DE 60009911D1
Authority
DE
Germany
Prior art keywords
receptor ligands
thiazole derivatives
crf receptor
amino thiazole
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009911T
Other languages
English (en)
Other versions
DE60009911T2 (de
Inventor
Evelyne Fontaine
Michel Geslin
Danielle Gully
Antoine Pradines
Pierre Roger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of DE60009911D1 publication Critical patent/DE60009911D1/de
Publication of DE60009911T2 publication Critical patent/DE60009911T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
DE60009911T 1999-07-15 2000-07-11 Aminothiazolderivate und ihre verwendung als crf-rezeptor-liganden Expired - Lifetime DE60009911T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9909144A FR2796380B3 (fr) 1999-07-15 1999-07-15 Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
FR9909144 1999-07-15
PCT/FR2000/001995 WO2001005776A1 (fr) 1999-07-15 2000-07-11 Derives d'aminothiazole et leur utilisation comme ligands des recepteurs crf

Publications (2)

Publication Number Publication Date
DE60009911D1 true DE60009911D1 (de) 2004-05-19
DE60009911T2 DE60009911T2 (de) 2005-03-10

Family

ID=9548107

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009911T Expired - Lifetime DE60009911T2 (de) 1999-07-15 2000-07-11 Aminothiazolderivate und ihre verwendung als crf-rezeptor-liganden

Country Status (36)

Country Link
US (2) US6586456B1 (de)
EP (1) EP1200419B1 (de)
JP (1) JP4949582B2 (de)
KR (1) KR100707320B1 (de)
CN (1) CN1167692C (de)
AR (1) AR024747A1 (de)
AT (1) ATE264315T1 (de)
AU (1) AU772683B2 (de)
BR (1) BR0012478B1 (de)
CA (1) CA2378792C (de)
CO (1) CO5200792A1 (de)
CZ (1) CZ300937B6 (de)
DE (1) DE60009911T2 (de)
DK (1) DK1200419T3 (de)
EA (1) EA005159B1 (de)
EE (1) EE05004B1 (de)
ES (1) ES2220504T3 (de)
FR (1) FR2796380B3 (de)
HK (1) HK1045692B (de)
HU (1) HU229069B1 (de)
IL (2) IL147282A0 (de)
IS (1) IS2314B (de)
ME (1) MEP26608A (de)
MX (1) MXPA02000545A (de)
NO (1) NO324352B1 (de)
NZ (1) NZ516397A (de)
PL (1) PL206515B1 (de)
PT (1) PT1200419E (de)
RS (1) RS50443B (de)
SI (1) SI1200419T1 (de)
SK (1) SK287069B6 (de)
TR (1) TR200200125T2 (de)
TW (1) TWI278453B (de)
UA (1) UA73125C2 (de)
WO (1) WO2001005776A1 (de)
ZA (1) ZA200200221B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2423156A1 (en) * 2000-09-21 2002-03-28 Bristol-Myers Squibb Company Substituted azole derivatives as inhibitors of corticotropin releasing factor
WO2003015777A1 (en) * 2001-08-13 2003-02-27 Lion Bioscience Ag Nr1h4 nuclear receptor binding compounds
US6993173B2 (en) 2001-10-12 2006-01-31 Duke University Methods for estimating probe cell locations in high-density synthetic DNA microarrays
EP2527447A1 (de) 2004-06-03 2012-11-28 Athlomics Pty Ltd Mittel und Verfahren zur Diagnose von Stress
JP2008509923A (ja) * 2004-08-13 2008-04-03 ジェネンテック・インコーポレーテッド Ａｔｐ利用酵素のチアゾールベースのインヒビター
EP1834641A1 (de) * 2006-03-16 2007-09-19 Sanofi-Aventis CRF1-Rezeptorantagonisten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndromes, und/oder Übergewicht und/oder Dyslipoproteinemie
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
WO2013160317A2 (en) * 2012-04-23 2013-10-31 Holsboermaschmeyer Neurochemie Gmbh Crhr1 antagonists for use in the treatment of patients having crh overactivity
GB201210686D0 (en) 2012-06-15 2012-08-01 Holsboermaschmeyer Neurochemie Gmbh V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en) 2013-06-17 2013-07-31 Max Planck Innovation Gmbh Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
HUE068315T2 (hu) 2014-01-21 2024-12-28 Neurocrine Biosciences Inc CRF1 receptor antagonisták kongenitális adrenális hiperplázia kezelésére
JP7532328B2 (ja) * 2018-12-07 2024-08-13 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態
HRP20251224T1 (hr) * 2018-12-07 2025-12-19 Neurocrine Biosciences, Inc. Antagonist crf1 receptora, farmaceutski pripravci i njihovi čvrsti oblici za liječenje kongenitalne adrenalne hiperplazije
EP4034111A1 (de) 2019-09-27 2022-08-03 Neurocrine Biosciences, Inc. Crf-rezeptorantagonisten und verfahren zur verwendung
US20230255942A1 (en) 2020-06-10 2023-08-17 Neurocrine Biosciences, Inc. Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692893B1 (fr) * 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
FR2714059B1 (fr) 1993-12-21 1996-03-08 Sanofi Elf Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
FR2735777B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2754258B1 (fr) * 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant

Also Published As

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US8420679B2 (en) 2013-04-16
NO20020155D0 (no) 2002-01-11
ATE264315T1 (de) 2004-04-15
UA73125C2 (uk) 2005-06-15
DK1200419T3 (da) 2004-07-19
CA2378792C (en) 2009-11-10
CO5200792A1 (es) 2002-09-27
PL352901A1 (en) 2003-09-22
NZ516397A (en) 2004-01-30
SK382002A3 (en) 2002-07-02
IS2314B (is) 2007-11-15
PT1200419E (pt) 2004-07-30
CN1167692C (zh) 2004-09-22
NO20020155L (no) 2002-03-15
CA2378792A1 (en) 2001-01-25
JP4949582B2 (ja) 2012-06-13
EE05004B1 (et) 2008-04-15
KR20020015373A (ko) 2002-02-27
TWI278453B (en) 2007-04-11
FR2796380B3 (fr) 2001-08-17
TR200200125T2 (tr) 2002-09-23
CN1370154A (zh) 2002-09-18
SK287069B6 (sk) 2009-11-05
US6586456B1 (en) 2003-07-01
FR2796380A1 (fr) 2001-01-19
PL206515B1 (pl) 2010-08-31
AU772683B2 (en) 2004-05-06
ES2220504T3 (es) 2004-12-16
RS50443B (sr) 2010-03-02
BR0012478B1 (pt) 2013-10-15
HK1045692A1 (en) 2002-12-06
KR100707320B1 (ko) 2007-04-13
IS6219A (is) 2002-01-03
MEP26608A (en) 2010-06-10
NO324352B1 (no) 2007-09-24
ZA200200221B (en) 2003-04-30
HUP0202387A2 (hu) 2002-11-28
HUP0202387A3 (en) 2004-12-28
BR0012478A (pt) 2002-04-02
HK1045692B (zh) 2004-11-26
MXPA02000545A (es) 2002-07-30
EA005159B1 (ru) 2004-12-30
DE60009911T2 (de) 2005-03-10
AU6452100A (en) 2001-02-05
AR024747A1 (es) 2002-10-23
CZ2002137A3 (cs) 2002-04-17
SI1200419T1 (en) 2004-08-31
IL147282A (en) 2008-04-13
JP2003505380A (ja) 2003-02-12
EP1200419B1 (de) 2004-04-14
CZ300937B6 (cs) 2009-09-16
EP1200419A1 (de) 2002-05-02
EE200200022A (et) 2003-04-15
US20070281919A1 (en) 2007-12-06
EA200101234A1 (ru) 2002-08-29
YU1302A (sh) 2005-03-15
WO2001005776A1 (fr) 2001-01-25
IL147282A0 (en) 2002-08-14
HU229069B1 (en) 2013-07-29

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