DE60008884D1 - Verfahren zur herstellung von 2-methoxy-4-(n-t-butylamino-carbonyl)-benzolsulfonsaürechlorid - Google Patents
Verfahren zur herstellung von 2-methoxy-4-(n-t-butylamino-carbonyl)-benzolsulfonsaürechloridInfo
- Publication number
- DE60008884D1 DE60008884D1 DE60008884T DE60008884T DE60008884D1 DE 60008884 D1 DE60008884 D1 DE 60008884D1 DE 60008884 T DE60008884 T DE 60008884T DE 60008884 T DE60008884 T DE 60008884T DE 60008884 D1 DE60008884 D1 DE 60008884D1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- general formula
- methoxy
- chloride
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 title abstract 3
- AFZVINMAZDQYFV-UHFFFAOYSA-N CC(C)(C)NC(C(C=C1)=CC(OC)=C1S(O)(=O)=O)=O Chemical compound CC(C)(C)NC(C(C=C1)=CC(OC)=C1S(O)(=O)=O)=O AFZVINMAZDQYFV-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- XHQZJYCNDZAGLW-UHFFFAOYSA-N 3-methoxybenzoic acid Chemical compound COC1=CC=CC(C(O)=O)=C1 XHQZJYCNDZAGLW-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001035 methylating effect Effects 0.000 abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 2
- 230000001131 transforming effect Effects 0.000 abstract 2
- DNUYOWCKBJFOGS-UHFFFAOYSA-N 2-[[10-(2,2-dicarboxyethyl)anthracen-9-yl]methyl]propanedioic acid Chemical compound C1=CC=C2C(CC(C(=O)O)C(O)=O)=C(C=CC=C3)C3=C(CC(C(O)=O)C(O)=O)C2=C1 DNUYOWCKBJFOGS-UHFFFAOYSA-N 0.000 abstract 1
- RFXNLHJLTSWQDE-UHFFFAOYSA-N 3-hydroxy-4-sulfobenzoic acid Chemical compound OC(=O)C1=CC=C(S(O)(=O)=O)C(O)=C1 RFXNLHJLTSWQDE-UHFFFAOYSA-N 0.000 abstract 1
- VQCHPXGONTUEPJ-UHFFFAOYSA-N 3-methoxy-4-sulfobenzoic acid Chemical compound COC1=CC(C(O)=O)=CC=C1S(O)(=O)=O VQCHPXGONTUEPJ-UHFFFAOYSA-N 0.000 abstract 1
- FQBFGERKZZFZNX-UHFFFAOYSA-N 4-(tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride Chemical compound COC1=CC(C(=O)NC(C)(C)C)=CC=C1S(Cl)(=O)=O FQBFGERKZZFZNX-UHFFFAOYSA-N 0.000 abstract 1
- QWEZBKWXCKXTJG-UHFFFAOYSA-N 4-chlorosulfonyl-3-methoxybenzoyl chloride Chemical compound COC1=CC(C(Cl)=O)=CC=C1S(Cl)(=O)=O QWEZBKWXCKXTJG-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- IJFXRHURBJZNAO-UHFFFAOYSA-N meta--hydroxybenzoic acid Natural products OC(=O)C1=CC=CC(O)=C1 IJFXRHURBJZNAO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
- C07C303/06—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/57—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
- C07C309/60—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902375A HU225150B1 (en) | 1999-07-15 | 1999-07-15 | Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride |
| HU9902375 | 1999-07-15 | ||
| PCT/HU2000/000080 WO2001005754A1 (en) | 1999-07-15 | 2000-07-13 | Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60008884D1 true DE60008884D1 (de) | 2004-04-15 |
| DE60008884T2 DE60008884T2 (de) | 2005-02-03 |
Family
ID=89998737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60008884T Expired - Lifetime DE60008884T2 (de) | 1999-07-15 | 2000-07-13 | Verfahren zur herstellung von 2-methoxy-4-(n-t-butylamino-carbonyl)-benzolsulfonsaürechlorid |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6548702B1 (de) |
| EP (1) | EP1202960B1 (de) |
| JP (1) | JP4636761B2 (de) |
| CN (1) | CN1164571C (de) |
| AT (1) | ATE261430T1 (de) |
| AU (1) | AU6308300A (de) |
| BR (1) | BR0012430B1 (de) |
| CA (1) | CA2378337C (de) |
| CZ (1) | CZ2002146A3 (de) |
| DE (1) | DE60008884T2 (de) |
| ES (1) | ES2215699T3 (de) |
| HR (1) | HRP20020141B1 (de) |
| HU (1) | HU225150B1 (de) |
| MX (1) | MXPA01013342A (de) |
| PL (1) | PL199425B1 (de) |
| SK (1) | SK286031B6 (de) |
| WO (1) | WO2001005754A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1421064E (pt) * | 2001-07-31 | 2005-08-31 | Sanofi Aventis | Processo para a preparacao de derivados de 3-espiro'ciclohexan-1,3'-'3h}indolin-2'-ona} |
| CN105621518A (zh) * | 2015-12-29 | 2016-06-01 | 浙江奇彩环境科技股份有限公司 | 一种3,4-二氯苯磺酸废水的资源化处理方法 |
| CN110372548A (zh) * | 2018-04-12 | 2019-10-25 | 南京化学试剂股份有限公司 | 一种5-磺基水杨酸的精制方法 |
| CN113402437B (zh) * | 2021-06-29 | 2023-07-14 | 河北维达康生物科技有限公司 | 一种合成膳食补充剂褪黑素的新方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953507A (en) | 1973-08-31 | 1976-04-27 | Stauffer Chemical Company | N-t-butyl-α-(3,5-substituted phenoxy) alkyl amides and their use as herbicides |
| FR2740136B1 (fr) * | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
| FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1999
- 1999-07-15 HU HU9902375A patent/HU225150B1/hu not_active IP Right Cessation
-
2000
- 2000-07-13 EP EP00949824A patent/EP1202960B1/de not_active Expired - Lifetime
- 2000-07-13 CZ CZ2002146A patent/CZ2002146A3/cs unknown
- 2000-07-13 DE DE60008884T patent/DE60008884T2/de not_active Expired - Lifetime
- 2000-07-13 ES ES00949824T patent/ES2215699T3/es not_active Expired - Lifetime
- 2000-07-13 PL PL352466A patent/PL199425B1/pl not_active IP Right Cessation
- 2000-07-13 CN CNB008102945A patent/CN1164571C/zh not_active Expired - Fee Related
- 2000-07-13 US US10/030,655 patent/US6548702B1/en not_active Expired - Fee Related
- 2000-07-13 AT AT00949824T patent/ATE261430T1/de not_active IP Right Cessation
- 2000-07-13 MX MXPA01013342A patent/MXPA01013342A/es active IP Right Grant
- 2000-07-13 AU AU63083/00A patent/AU6308300A/en not_active Abandoned
- 2000-07-13 BR BRPI0012430-3A patent/BR0012430B1/pt not_active IP Right Cessation
- 2000-07-13 SK SK47-2002A patent/SK286031B6/sk not_active IP Right Cessation
- 2000-07-13 CA CA002378337A patent/CA2378337C/en not_active Expired - Fee Related
- 2000-07-13 WO PCT/HU2000/000080 patent/WO2001005754A1/en not_active Ceased
- 2000-07-13 HR HR20020141A patent/HRP20020141B1/xx not_active IP Right Cessation
- 2000-07-13 JP JP2001511415A patent/JP4636761B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL352466A1 (en) | 2003-08-25 |
| ATE261430T1 (de) | 2004-03-15 |
| CN1360569A (zh) | 2002-07-24 |
| CA2378337A1 (en) | 2001-01-25 |
| HU225150B1 (en) | 2006-07-28 |
| BR0012430A (pt) | 2002-03-26 |
| JP4636761B2 (ja) | 2011-02-23 |
| HRP20020141A2 (en) | 2003-10-31 |
| DE60008884T2 (de) | 2005-02-03 |
| ES2215699T3 (es) | 2004-10-16 |
| MXPA01013342A (es) | 2002-08-20 |
| SK286031B6 (sk) | 2008-01-07 |
| EP1202960B1 (de) | 2004-03-10 |
| AU6308300A (en) | 2001-02-05 |
| WO2001005754A1 (en) | 2001-01-25 |
| CN1164571C (zh) | 2004-09-01 |
| CA2378337C (en) | 2008-05-20 |
| SK472002A3 (en) | 2003-02-04 |
| HU9902375D0 (en) | 1999-10-28 |
| HUP9902375A3 (en) | 2002-11-28 |
| JP2003505366A (ja) | 2003-02-12 |
| CZ2002146A3 (cs) | 2002-11-13 |
| HRP20020141B1 (en) | 2010-09-30 |
| PL199425B1 (pl) | 2008-09-30 |
| BR0012430B1 (pt) | 2011-05-17 |
| HUP9902375A2 (hu) | 2001-05-28 |
| EP1202960A1 (de) | 2002-05-08 |
| US6548702B1 (en) | 2003-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-AVENTIS, PARIS, FR |