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DE60007316D1 - Verfahren zur mikroverkapselung von wasserlöslichen substanzen - Google Patents

Verfahren zur mikroverkapselung von wasserlöslichen substanzen

Info

Publication number
DE60007316D1
DE60007316D1 DE60007316T DE60007316T DE60007316D1 DE 60007316 D1 DE60007316 D1 DE 60007316D1 DE 60007316 T DE60007316 T DE 60007316T DE 60007316 T DE60007316 T DE 60007316T DE 60007316 D1 DE60007316 D1 DE 60007316D1
Authority
DE
Germany
Prior art keywords
micro
soluble substances
present
encoding
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007316T
Other languages
English (en)
Other versions
DE60007316T2 (de
Inventor
Evelyne Vuaridel
Piero Orsolini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Debio Recherche Pharmaceutique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Recherche Pharmaceutique SA filed Critical Debio Recherche Pharmaceutique SA
Publication of DE60007316D1 publication Critical patent/DE60007316D1/de
Application granted granted Critical
Publication of DE60007316T2 publication Critical patent/DE60007316T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60007316T 1999-04-15 2000-04-14 Verfahren zur mikroverkapselung von wasserlöslichen substanzen Expired - Lifetime DE60007316T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99107570A EP1044683A1 (de) 1999-04-15 1999-04-15 Einschrittdispersionsverfahren zur Mikroverkapselung von wasserlöslichen Substanzen
EP99107570 1999-04-15
PCT/CH2000/000218 WO2000062761A1 (en) 1999-04-15 2000-04-14 Process for microencapsulation of water soluble substances

Publications (2)

Publication Number Publication Date
DE60007316D1 true DE60007316D1 (de) 2004-01-29
DE60007316T2 DE60007316T2 (de) 2004-09-30

Family

ID=8237970

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007316T Expired - Lifetime DE60007316T2 (de) 1999-04-15 2000-04-14 Verfahren zur mikroverkapselung von wasserlöslichen substanzen

Country Status (11)

Country Link
US (1) US6777002B1 (de)
EP (2) EP1044683A1 (de)
JP (1) JP2002542184A (de)
AT (1) ATE256458T1 (de)
AU (1) AU779712B2 (de)
CA (1) CA2369808A1 (de)
DE (1) DE60007316T2 (de)
DK (1) DK1196148T3 (de)
ES (1) ES2213572T3 (de)
PT (1) PT1196148E (de)
WO (1) WO2000062761A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004515527A (ja) * 2000-12-13 2004-05-27 メルクル・ゲーエムベーハー 放出特性改良微粒子およびその製造方法
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules
CA2435415A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Microparticles of biodegradable polymer encapsulating a biologically active substance
EP1450766B1 (de) * 2001-10-10 2015-04-22 Pierre Fabre Medicament Biologisch abbaubare mikrokügelchen mit verlängerter freisetzung und verfahren zu ihrer herstellung
WO2005003180A2 (en) 2003-04-10 2005-01-13 Pr Pharmaceuticals A method for the production of emulsion-based micro particles
AU2004259208B2 (en) * 2003-07-15 2011-04-28 Evonik Corporation Method for the preparation of controlled release formulations
JP5165240B2 (ja) 2003-07-23 2013-03-21 ピーアール ファーマシューティカルズ， インコーポレイテッド 徐放組成物
ES2424255T3 (es) * 2004-11-08 2013-09-30 Baxter International Inc. Composiciones particuladas de inhibidores de tubulina
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
JP2007002197A (ja) * 2005-06-27 2007-01-11 Kuraray Co Ltd コーティング剤及びコーティング皮膜
GB0711007D0 (en) * 2007-06-07 2007-07-18 Isis Innovation Polymeric microparticles
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US8236350B2 (en) * 2008-08-01 2012-08-07 The Regents Of The University Of Michigan Polymer for tissue engineering applications and drug delivery
EP2334288B1 (de) * 2008-09-18 2021-05-19 Evonik Corporation Mikroverkapselungsverfahren mit lösungsmittel und salz
CA2749993C (en) * 2009-01-23 2016-12-20 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
US8927619B2 (en) 2011-12-21 2015-01-06 Jorg Thomas Wilken Color-stabilized iodopropynyl butylcarbamate
US9308172B2 (en) * 2012-10-26 2016-04-12 Board Of Trustees Of Michigan State University Device and method for encapsulation of hydrophilic materials
US20200383932A1 (en) * 2019-06-05 2020-12-10 The Florida International University Board Of Trustees Biotherapy for viral infections using biopolymer based micro/nanogels
US12263252B2 (en) 2019-06-05 2025-04-01 The Florida International University Board Of Trustees Biotherapy for viral infections using biopolymer based micro/nanogels

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2010116A1 (de) * 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
JP2582186B2 (ja) * 1989-05-04 1997-02-19 サウザン リサーチ インスティチュート カプセル封じ法及びその製品
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5238714A (en) * 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
US6090925A (en) * 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CA2474701C (en) * 1993-11-19 2009-01-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradeable microparticles containing a biologically active agent
KR0162872B1 (ko) * 1996-04-01 1998-12-01 김은영 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
US6777002B1 (en) 2004-08-17
EP1196148B1 (de) 2003-12-17
PT1196148E (pt) 2004-05-31
CA2369808A1 (en) 2000-10-26
ES2213572T3 (es) 2004-09-01
AU3651800A (en) 2000-11-02
DK1196148T3 (da) 2004-04-13
JP2002542184A (ja) 2002-12-10
ATE256458T1 (de) 2004-01-15
WO2000062761A1 (en) 2000-10-26
EP1196148A1 (de) 2002-04-17
DE60007316T2 (de) 2004-09-30
AU779712B2 (en) 2005-02-10
EP1044683A1 (de) 2000-10-18

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