DE60006057D1 - Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel - Google Patents

Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel

Info

Publication number: DE60006057D1
Authority: DE; Germany
Prior art keywords: halo; optionally substituted; compounds; heteroarylphenylpyrazole; analgesic
Prior art date: 1999-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60006057T

Other languages

English (en)

Other versions

DE60006057T2 (de

Inventor

Kazuo Ando

K Kawamura

Tomoki Kato

Martha Lou Minich

Kristin Marie Lundy

Hengmiao Cheng

Jin Li

Brian Scott Bronk

Subas Man Sakya

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Products Inc

Original Assignee

Pfizer Products Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-03

Filing date

2000-11-22

Publication date

2003-11-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22613380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60006057(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-11-22 Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc

2003-11-27 Publication of DE60006057D1 publication Critical patent/DE60006057D1/de

2004-05-27 Application granted granted Critical

2004-05-27 Publication of DE60006057T2 publication Critical patent/DE60006057T2/de

2020-11-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Oncology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE60006057T 1999-12-03 2000-11-22 Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel Expired - Fee Related DE60006057T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16889099P	1999-12-03	1999-12-03
US168890P		1999-12-03

Publications (2)

Publication Number	Publication Date
DE60006057D1 true DE60006057D1 (de)	2003-11-27
DE60006057T2 DE60006057T2 (de)	2004-05-27

Family

ID=22613380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60006057T Expired - Fee Related DE60006057T2 (de)	1999-12-03	2000-11-22	Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel

Country Status (12)

Country	Link
US (1)	US6649636B1 (de)
EP (1)	EP1104759B1 (de)
JP (1)	JP3341029B2 (de)
AT (1)	ATE252576T1 (de)
BR (1)	BR0006333A (de)
CA (1)	CA2327256A1 (de)
DE (1)	DE60006057T2 (de)
DK (1)	DK1104759T3 (de)
ES (1)	ES2208227T3 (de)
MX (1)	MXPA00011845A (de)
PT (1)	PT1104759E (de)
TR (1)	TR200302047T4 (de)

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US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6555581B1 (en)	2001-02-15	2003-04-29	Jones Pharma, Inc.	Levothyroxine compositions and methods
KR20040100835A (ko)	2001-02-15	2004-12-02	킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨	안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법
ATE298749T1 (de) *	2001-07-05	2005-07-15	Pfizer Prod Inc	Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
GT200200183A (es)	2001-09-28	2003-05-23		Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037330A1 (en)	2001-11-02	2003-05-08	Pfizer Products Inc.	Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors
WO2003037335A1 (en)	2001-11-02	2003-05-08	Pfizer Products Inc.	5-heteroatom-substituted pyrazoles
WO2003037351A1 (en)	2001-11-02	2003-05-08	Pfizer Products Inc.	Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors
JP2005515171A (ja)	2001-11-02	2005-05-26	ファイザー・プロダクツ・インク	５−ヘテロ原子含有ピラゾールの効率的な合成法
KR100467668B1 (ko)	2002-08-07	2005-01-24	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
US20050288299A1 (en) *	2002-10-09	2005-12-29	Mavunkel Babu J	Azaindole derivatives as inhibitors of p38 kinase
US20050043212A1 (en) *	2002-10-09	2005-02-24	Ford Kirschenbaum	Differential inhibition of p38 map kinase isoforms
WO2004032874A2 (en) *	2002-10-09	2004-04-22	Scios Inc.	AZAINDOLE DERIVATIVES AS INHIBITORS OF p38 KINASE
KR100491317B1 (ko) *	2002-11-26	2005-05-24	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
BR0316332A (pt) *	2002-12-02	2005-09-27	Astellas Pharma Inc	Composto pirazólico, composição farmacêutica e agente analgésico contendo o mesmo, processo para sua preparação e seu uso e pacote comercial
ES2214130B1 (es) *	2003-02-13	2005-12-01	Almirall Prodesfarma, S.A.	2-3'-bipiridinas.
ES2213485B1 (es) *	2003-02-13	2005-12-16	Almirall Prodesfarma, S.A.	Derivados de la 2-fenilpiran-4-ona.
ES2214129B1 (es) *	2003-02-13	2005-12-01	Almirall Prodesfarma, S.A.	3-fenilfuran-2-onas.
GB0308318D0 (en)	2003-04-10	2003-05-14	Merck Sharp & Dohme	Therapeutic agents
MXPA06013118A (es) *	2004-05-12	2007-02-28	Schering Corp	Antagonistas de cxcr1 y cxcr2 de quimocina.
CN102089303A (zh) *	2008-07-17	2011-06-08	旭化成制药株式会社	含氮杂环化合物
CA3025492A1 (en)	2015-06-01	2016-12-08	Bantam Pharmaceutical, Llc	Substituted pyrazole and pyrrole compounds and methods for using them for inhibition of initiation of translation and treatment of diseases and disorders relating thereto
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists
CA3081983A1 (en)	2016-11-30	2018-06-07	Bantam Pharmaceutical, Llc	Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
CA3082011A1 (en)	2016-11-30	2018-06-07	Bantam Pharmaceutical, Llc	Methods of using substituted pyrazole and pyrrole compounds and for treatment of hyperproliferative diseases

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PH27357A (en)	1989-09-22	1993-06-21	Fujisawa Pharmaceutical Co	Pyrazole derivatives and pharmaceutical compositions comprising the same
IL104311A (en)	1992-02-05	1997-07-13	Fujisawa Pharmaceutical Co	Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5474995A (en)	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
US5475018A (en)	1993-11-30	1995-12-12	G. D. Searle & Co.	1,5-diphenyl pyrazole compounds for treatment of inflammation
US5434178A (en)	1993-11-30	1995-07-18	G.D. Searle & Co.	1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
CZ294630B6 (cs)	1993-11-30	2005-02-16	G. D. Searle & Co.	Substituované pyrazolylbenzensulfonamidy pro léčení zánětů
US5401765A (en)	1993-11-30	1995-03-28	G. D. Searle	1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
AU3201095A (en)	1994-07-27	1996-02-22	G.D. Searle & Co.	Substituted thiazoles for the treatment of inflammation
US5620999A (en)	1994-07-28	1997-04-15	Weier; Richard M.	Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5585504A (en)	1994-09-16	1996-12-17	Merck & Co., Inc.	Process of making cox-2 inhibitors having a lactone bridge
DE4441758A1 (de)	1994-11-23	1996-05-30	Siemens Ag	Verfahren und Vorrichtung zur Reduzierung von Oberschwingungs-Netzrückwirkungen eines selbstgeführten Multilevel-Wechselrichters
US5691374A (en)	1995-05-18	1997-11-25	Merck Frosst Canada Inc.	Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5756529A (en) *	1995-09-29	1998-05-26	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
GB9520584D0 (en)	1995-10-09	1995-12-13	Fujisawa Pharmaceutical Co	Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
UA57002C2 (uk)	1995-10-13	2003-06-16	Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі.	Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
DE69618820T2 (de)	1995-10-30	2002-06-20	Merck Frosst Canada & Co., Halifax	3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren

2000
- 2000-11-22 AT AT00310356T patent/ATE252576T1/de not_active IP Right Cessation
- 2000-11-22 EP EP00310356A patent/EP1104759B1/de not_active Expired - Lifetime
- 2000-11-22 DK DK00310356T patent/DK1104759T3/da active
- 2000-11-22 TR TR2003/02047T patent/TR200302047T4/xx unknown
- 2000-11-22 DE DE60006057T patent/DE60006057T2/de not_active Expired - Fee Related
- 2000-11-22 PT PT00310356T patent/PT1104759E/pt unknown
- 2000-11-22 ES ES00310356T patent/ES2208227T3/es not_active Expired - Lifetime
- 2000-11-28 US US09/723,608 patent/US6649636B1/en not_active Expired - Fee Related
- 2000-11-30 MX MXPA00011845A patent/MXPA00011845A/es active IP Right Grant
- 2000-12-01 JP JP2000366615A patent/JP3341029B2/ja not_active Expired - Fee Related
- 2000-12-01 CA CA002327256A patent/CA2327256A1/en not_active Abandoned
- 2000-12-04 BR BR0006333-9A patent/BR0006333A/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1104759T3 (da)	2004-01-26
EP1104759B1 (de)	2003-10-22
EP1104759A1 (de)	2001-06-06
ATE252576T1 (de)	2003-11-15
CA2327256A1 (en)	2001-06-03
ES2208227T3 (es)	2004-06-16
BR0006333A (pt)	2001-12-11
PT1104759E (pt)	2004-01-30
JP2001187791A (ja)	2001-07-10
MXPA00011845A (es)	2002-08-20
US6649636B1 (en)	2003-11-18
JP3341029B2 (ja)	2002-11-05
TR200302047T4 (tr)	2004-01-21
DE60006057T2 (de)	2004-05-27

Publication	Publication Date	Title
ATE234299T1 (de)	2003-03-15	Sulfamoylheteroarylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel
DE60006057D1 (de)	2003-11-27	Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
HUP0203971A2 (hu)	2003-03-28	Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
NO950297D0 (no)	1995-01-26	Prolinamidderivater
ATE180468T1 (de)	1999-06-15	Anthranilsäure derivate
ATE253545T1 (de)	2003-11-15	Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
BRPI0413232A (pt)	2006-10-03	novos compostos tendo atividade inibitória contra os trasnportadores dependentes de sódio
GB9801690D0 (en)	1998-03-25	Therapeutic agents
AR050045A1 (es)	2006-09-27	Derivados de pirrolo[3,4-c]pirazol activos como inhibidores de quinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden
ATE215945T1 (de)	2002-04-15	Bicyclische carbonyl-indolverbindungen als entzündungshemmende/ analgetische wirkstoffe und als cox-2 inhibitoren
DE69428142D1 (de)	2001-10-11	Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
AU7517400A (en)	2001-04-24	N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
ATE316962T1 (de)	2006-02-15	Pyrimidin-derivate als selective inhibitoren von cox-2
DE69707372D1 (de)	2001-11-22	Verwendung eines Phosphorsäurediesters zur Herstellung eines Arzneimittels zur Behandlung von Akne
ES2073258T3 (es)	1995-08-01	Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
AU640590B2 (en)	1993-08-26	3-(1h-indazol-3-yl)-4-pyridinamines
EA200000532A2 (ru)	2000-12-25	НОВЫЕ СОЕДИНЕНИЯ 7-ОКСО-2,3,7,14-ТЕТРАГИДРО-1H-БЕНЗО[b]-ПИРАНО [3,2-h]АКРИДИНКАРБОКСИЛАТА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
ATE258934T1 (de)	2004-02-15	Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
DE69528984D1 (de)	2003-01-09	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten

Legal Events

Date	Code	Title	Description
2004-11-18	8364	No opposition during term of opposition
2007-09-13	8339	Ceased/non-payment of the annual fee