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DE4321978A1 - Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel - Google Patents

Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Info

Publication number
DE4321978A1
DE4321978A1 DE4321978A DE4321978A DE4321978A1 DE 4321978 A1 DE4321978 A1 DE 4321978A1 DE 4321978 A DE4321978 A DE 4321978A DE 4321978 A DE4321978 A DE 4321978A DE 4321978 A1 DE4321978 A1 DE 4321978A1
Authority
DE
Germany
Prior art keywords
formula
liponucleotides
pyridine
alkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4321978A
Other languages
German (de)
English (en)
Inventor
Dieter Dr Herrmann
Harald Dipl Chem Dr Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE4321978A priority Critical patent/DE4321978A1/de
Priority to PCT/EP1994/002123 priority patent/WO1995001362A1/fr
Priority to JP7503270A priority patent/JPH08512040A/ja
Priority to CA002165979A priority patent/CA2165979A1/fr
Priority to AU73449/94A priority patent/AU7344994A/en
Priority to EP94922244A priority patent/EP0706530A1/fr
Publication of DE4321978A1 publication Critical patent/DE4321978A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE4321978A 1993-07-01 1993-07-01 Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel Withdrawn DE4321978A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE4321978A DE4321978A1 (de) 1993-07-01 1993-07-01 Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
PCT/EP1994/002123 WO1995001362A1 (fr) 1993-07-01 1994-06-29 Liponucleotides de desoxynucleosides, leur fabrication et leur utilisation comme medicaments antiviraux
JP7503270A JPH08512040A (ja) 1993-07-01 1994-06-29 デオキシヌクレオシドのリポヌクレオチド、それらの製造方法および抗ウイルス薬としてのそれらの用途
CA002165979A CA2165979A1 (fr) 1993-07-01 1994-06-29 Liponucleotides de desoxynucleosides; leur preparation et leur utilisation comme agents pharmaceutiques antiviraux
AU73449/94A AU7344994A (en) 1993-07-01 1994-06-29 Liponucleotides of desoxynucleosides, their preaparation and their use as anti-viral drugs
EP94922244A EP0706530A1 (fr) 1993-07-01 1994-06-29 Liponucleotides de desoxynucleosides, leur fabrication et leur utilisation comme medicaments antiviraux

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4321978A DE4321978A1 (de) 1993-07-01 1993-07-01 Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Publications (1)

Publication Number Publication Date
DE4321978A1 true DE4321978A1 (de) 1995-01-12

Family

ID=6491748

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4321978A Withdrawn DE4321978A1 (de) 1993-07-01 1993-07-01 Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Country Status (6)

Country Link
EP (1) EP0706530A1 (fr)
JP (1) JPH08512040A (fr)
AU (1) AU7344994A (fr)
CA (1) CA2165979A1 (fr)
DE (1) DE4321978A1 (fr)
WO (1) WO1995001362A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638528B2 (en) 1999-10-28 2009-12-29 Wake Forest University School Of Medicine Compositions and methods for targeting cancer cells

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4402492A1 (de) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
EP1460082A1 (fr) * 2003-03-19 2004-09-22 Heidelberg Pharma Holding GmbH Dérivés phospholipidiques de clofarabine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE4111730A1 (de) * 1991-04-10 1992-10-15 Knoll Ag Neue cytarabin-derivate, ihre herstellung und verwendung
WO1993000910A1 (fr) * 1991-07-12 1993-01-21 Vical, Inc. Liponucleosides antiviraux: traitement de l'hepatite b
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
DE4204031A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue lipidphosphonsaeure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638528B2 (en) 1999-10-28 2009-12-29 Wake Forest University School Of Medicine Compositions and methods for targeting cancer cells
US8138200B2 (en) 1999-10-28 2012-03-20 Wake Forest University Compositions and methods for double-targeting virus infections and targeting cancer cells

Also Published As

Publication number Publication date
CA2165979A1 (fr) 1995-01-12
JPH08512040A (ja) 1996-12-17
EP0706530A1 (fr) 1996-04-17
WO1995001362A1 (fr) 1995-01-12
AU7344994A (en) 1995-01-24

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee