DE3889853D1 - Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik. - Google Patents
Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.Info
- Publication number
- DE3889853D1 DE3889853D1 DE3889853T DE3889853T DE3889853D1 DE 3889853 D1 DE3889853 D1 DE 3889853D1 DE 3889853 T DE3889853 T DE 3889853T DE 3889853 T DE3889853 T DE 3889853T DE 3889853 D1 DE3889853 D1 DE 3889853D1
- Authority
- DE
- Germany
- Prior art keywords
- immunogenic potential
- polysaccharide
- immunoglobulin
- improved pharmacokinetics
- modified immunoglobulins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 3
- 102000018358 immunoglobulin Human genes 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title abstract 2
- 229940072221 immunoglobulins Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11815087A | 1987-11-05 | 1987-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3889853D1 true DE3889853D1 (de) | 1994-07-07 |
Family
ID=22376776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3889853T Expired - Lifetime DE3889853D1 (de) | 1987-11-05 | 1988-11-03 | Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0315456B1 (de) |
| JP (1) | JPH01163133A (de) |
| AT (1) | ATE106249T1 (de) |
| AU (1) | AU610946B2 (de) |
| DE (1) | DE3889853D1 (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541297A (en) * | 1988-04-01 | 1996-07-30 | Immunomedics, Inc. | Therapeutic conjugates of toxins and drugs |
| US8038994B2 (en) | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
| US5929049A (en) | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| DK2319928T3 (da) | 1998-10-23 | 2013-06-24 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| US6245879B1 (en) * | 1999-01-29 | 2001-06-12 | Shell Oil Company | Purification of 1,3-propanediol in carbonyl-containing stream |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| ITMI20010347A1 (it) * | 2001-02-21 | 2002-08-21 | Grisotech S A | Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale |
| SK288175B6 (sk) | 2001-05-11 | 2014-04-02 | Amgen Inc. | Látková kompozícia viažuca polypeptid TALL-1, kódujúca DNA, expresný vektor a hostiteľská bunka |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| PL376536A1 (pl) | 2002-08-28 | 2006-01-09 | Immunex Corporation | Kompozycje i sposoby leczenia chorób układu sercowo-naczyniowego |
| AU2004261941B2 (en) | 2003-07-25 | 2008-04-10 | Amgen Inc. | Antagonists and agonists of LDCAM and methods of use |
| SI2311873T1 (sl) | 2004-01-07 | 2018-12-31 | Novartis Vaccines And Diagnostics, Inc. | M-CSF-specifična monoklonska protitelesa in njihova uporaba |
| US8143380B2 (en) | 2004-07-08 | 2012-03-27 | Amgen Inc. | Therapeutic peptides |
| ES2629397T3 (es) | 2004-09-24 | 2017-08-09 | Amgen Inc. | Moléculas de Fc modificadas |
| CA2589860A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
| EP2311876A3 (de) | 2005-07-28 | 2011-04-27 | Novartis AG | M-CSF-spezifischer monoklonaler Antikörper und Verwendungen davon |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| EP1933873A4 (de) | 2005-10-13 | 2009-12-02 | Human Genome Sciences Inc | Verfahren und zusammensetzung zur verwendung bei der behandlung von patienten mit autoantikörper-positiven leiden |
| PE20070684A1 (es) | 2005-11-14 | 2007-08-06 | Amgen Inc | MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP |
| EP2010569A4 (de) | 2006-03-20 | 2009-09-09 | Xoma Technology Ltd | Für gastrin spezifische humane antikörper, materialien und methoden |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| AU2007254141B2 (en) | 2006-05-19 | 2012-10-11 | Glycofi, Inc. | Erythropoietin compositions |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| ATE540681T1 (de) | 2006-06-26 | 2012-01-15 | Amgen Inc | Verfahren zur behandlung von atherosklerose |
| EP2057193B1 (de) | 2006-08-04 | 2013-12-18 | Novartis AG | Ephb3-spezifischer antikörper und verwendungen davon |
| PL2059535T3 (pl) | 2006-08-18 | 2014-04-30 | Novartis Ag | Przeciwciało specyficzne względem PRLR i jego zastosowanie |
| EP2081602A2 (de) | 2006-10-25 | 2009-07-29 | Amgen Inc. | Therapeutische toxinpeptid-mittel |
| KR20140119831A (ko) | 2006-12-07 | 2014-10-10 | 노파르티스 아게 | Ｅｐｈｂ３에 대한 길항제 항체 |
| US8420779B2 (en) | 2007-05-22 | 2013-04-16 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| DK2181190T3 (da) | 2007-07-26 | 2014-03-31 | Amgen Inc | Modificerede lecithin-kolesterol-acyltransferase-enzymer |
| EP2261254A3 (de) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Antiamyloide Antikörper und deren Verwendungen |
| MX2010008096A (es) | 2008-01-25 | 2010-09-22 | Amgen Inc | Anticuerpos de ferroportina y metodos de uso. |
| EP2294087B1 (de) | 2008-05-01 | 2014-05-14 | Amgen, Inc. | Anti-hepcidin-antikörper und verfahren zu ihrer verwendung |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| WO2009158432A2 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| EA032727B1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Мутантный резистентный к протеолизу полипептид fgf21 и его применение |
| ES2441941T3 (es) | 2008-10-15 | 2014-02-07 | Baxter Healthcare Sa | Pegilación de factores de coagulación sanguínea recombinantes en presencia de anticuerpos enlazados |
| JP2012521197A (ja) | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | 担体免疫グロブリンおよびその使用 |
| EP4353247A3 (de) | 2009-05-05 | 2024-07-17 | Amgen Inc. | Fgf21-mutanten und verwendungen davon |
| EP2427207B1 (de) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Fgf21-mutanten und ihre verwendungen |
| JP2012530493A (ja) | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
| CN102647998A (zh) | 2009-06-19 | 2012-08-22 | 医学免疫有限责任公司 | 蛋白酶变体 |
| AU2010298036B2 (en) | 2009-09-25 | 2015-05-21 | Xoma Technology Ltd. | Screening methods |
| US8926976B2 (en) | 2009-09-25 | 2015-01-06 | Xoma Technology Ltd. | Modulators |
| CA2781532A1 (en) | 2009-11-20 | 2011-05-26 | Amgen Inc. | Anti-orai1 antigen binding protein that binds the second extracellular loop of orai1 |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| US9517264B2 (en) | 2010-04-15 | 2016-12-13 | Amgen Inc. | Human FGF receptor and β-Klotho binding proteins |
| CN103339145A (zh) | 2010-09-22 | 2013-10-02 | 安姆根有限公司 | 运载体免疫球蛋白及其用途 |
| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| CN108424451B (zh) | 2011-06-03 | 2022-09-09 | 佐马技术有限公司 | 对TGF-β具有特异性的抗体 |
| MX2014002260A (es) | 2011-08-31 | 2014-08-18 | Amgen Inc | Factor de crecimiento de fibroblasto 21 para usar en el tratamiento de diabetes tipo 1. |
| TW201315742A (zh) | 2011-09-26 | 2013-04-16 | Novartis Ag | 治療代謝病症之雙功能蛋白質 |
| UY34346A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de fusión para tratar trastornos metabólicos |
| EP2968503B1 (de) | 2013-03-15 | 2018-08-15 | Intrinsic LifeSciences LLC | Anti-hepcidin-antikörper und verwendungen davon |
| US20160235810A1 (en) | 2013-10-18 | 2016-08-18 | Novartis Ag | Methods of treating diabetes and related disorders |
| WO2016049036A1 (en) | 2014-09-22 | 2016-03-31 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| MA42985A (fr) | 2015-10-01 | 2018-08-22 | Amgen Inc | Traitement de troubles liés à l'acide biliaire |
| MA51586A (fr) | 2016-06-02 | 2019-04-10 | Abbvie Inc | Agoniste du récepteur des glucocorticoïdes et immunoconjugués de celui-ci |
| PE20201286A1 (es) | 2017-12-01 | 2020-11-24 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados de este |
| KR20220004979A (ko) | 2019-03-27 | 2022-01-12 | 유엠씨 우트레크트 홀딩 비.브이. | 조작된 iga 항체 및 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| US4732863A (en) * | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
| US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
-
1988
- 1988-11-03 DE DE3889853T patent/DE3889853D1/de not_active Expired - Lifetime
- 1988-11-03 EP EP88310372A patent/EP0315456B1/de not_active Expired - Lifetime
- 1988-11-03 AT AT88310372T patent/ATE106249T1/de not_active IP Right Cessation
- 1988-11-04 AU AU24755/88A patent/AU610946B2/en not_active Ceased
- 1988-11-05 JP JP63281158A patent/JPH01163133A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0315456A2 (de) | 1989-05-10 |
| EP0315456B1 (de) | 1994-06-01 |
| ATE106249T1 (de) | 1994-06-15 |
| AU610946B2 (en) | 1991-05-30 |
| EP0315456A3 (en) | 1990-03-28 |
| AU2475588A (en) | 1989-05-18 |
| JPH01163133A (ja) | 1989-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |