[go: up one dir, main page]

DE3883408D1 - Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen. - Google Patents

Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.

Info

Publication number
DE3883408D1
DE3883408D1 DE88300353T DE3883408T DE3883408D1 DE 3883408 D1 DE3883408 D1 DE 3883408D1 DE 88300353 T DE88300353 T DE 88300353T DE 3883408 T DE3883408 T DE 3883408T DE 3883408 D1 DE3883408 D1 DE 3883408D1
Authority
DE
Germany
Prior art keywords
avermectins
production
cultures used
cultures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88300353T
Other languages
English (en)
Other versions
DE3883408T2 (de
Inventor
Edmund William Hafner
Kelvin Scott Holdom
Shih-Jen Edward Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE3883408D1 publication Critical patent/DE3883408D1/de
Application granted granted Critical
Publication of DE3883408T2 publication Critical patent/DE3883408T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623Avermectin; Milbemycin; Ivermectin; C-076
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE88300353T 1987-01-23 1988-01-18 Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen. Expired - Lifetime DE3883408T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US651287A 1987-01-23 1987-01-23
US10782587A 1987-10-13 1987-10-13

Publications (2)

Publication Number Publication Date
DE3883408D1 true DE3883408D1 (de) 1993-09-30
DE3883408T2 DE3883408T2 (de) 1993-12-09

Family

ID=26675723

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88300353T Expired - Lifetime DE3883408T2 (de) 1987-01-23 1988-01-18 Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.

Country Status (26)

Country Link
EP (1) EP0284176B1 (de)
JP (1) JPH0817694B2 (de)
KR (1) KR900007937B1 (de)
CN (1) CN1065277C (de)
AP (1) AP53A (de)
AR (1) AR244344A1 (de)
AU (1) AU636709B2 (de)
BG (1) BG48572A3 (de)
CA (1) CA1338141C (de)
CZ (1) CZ290312B6 (de)
DE (1) DE3883408T2 (de)
DK (1) DK175724B1 (de)
EG (1) EG18796A (de)
ES (1) ES2058244T3 (de)
FI (1) FI90087C (de)
HU (1) HU203130B (de)
IE (1) IE62467B1 (de)
IL (1) IL85119A (de)
MA (1) MA21161A1 (de)
MX (1) MX169293B (de)
MY (1) MY102581A (de)
NO (2) NO172446C (de)
NZ (1) NZ223270A (de)
PT (1) PT86582B (de)
RU (1) RU2096462C1 (de)
YU (2) YU47877B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE89604T1 (de) * 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
GB8807280D0 (en) * 1988-03-26 1988-04-27 Pfizer Ltd Antiparasitic agents
GB8809232D0 (en) * 1988-04-19 1988-05-25 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
NZ238521A (en) * 1990-06-22 1992-12-23 Merck & Co Inc Process for the conversion of avermectin glycone to avermectin mono- and disaccharides by fermentation with streptomyces avermitilis ma6078
US5250422A (en) * 1990-10-15 1993-10-05 Merck & Co., Inc. Biotransformation process for the production of invermectin derivatives
NZ240128A (en) * 1990-10-15 1994-01-26 Merck & Co Inc Production of 13-beta and 5-beta ivermectin monoglucopyranosides from
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
CN1038330C (zh) * 1993-07-05 1998-05-13 塞泰克斯公司 阿弗麦菌素的生产与分离
CA2167520C (en) * 1993-07-30 1999-07-27 Claudio D. Denoya Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
US5466102A (en) 1993-12-16 1995-11-14 Kennametal Inc. System for coupling machine tools
GB9716567D0 (en) * 1997-08-05 1997-10-08 Pfizer Process
GB9825402D0 (en) 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
RU2147320C1 (ru) * 1999-09-22 2000-04-10 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Штамм streptomyces avermitilis ницб 132-продуцент авермектинов
RU2182174C2 (ru) * 2000-01-31 2002-05-10 Мосин Владимир Александрович Способ выделения авермектиновых комплексов
IL160619A0 (en) 2001-09-17 2004-07-25 Lilly Co Eli Pesticidal formulations pesticidal formulations
JP2005072084A (ja) 2003-08-28 2005-03-17 Toshiba Corp 半導体装置及びその製造方法
CN101560535B (zh) * 2009-05-26 2012-05-23 浙江升华拜克生物股份有限公司 一种基于代谢参数our补糖发酵生产阿维菌素工艺
US20120196821A1 (en) 2009-10-19 2012-08-02 Roger Mervyn Sargent Method and formulation for the control of parasites
RU2454420C1 (ru) * 2011-03-31 2012-06-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Цитотоксические полусинтетические производные макролидного антибиотика олигомицина а и способ их получения
CN104877925B (zh) * 2014-02-28 2018-05-25 中国科学院沈阳应用生态研究所 一种异壁放线菌和三种新的抗真菌maclafungins类化合物及其制备和应用
CN116602242B (zh) * 2023-05-08 2024-01-23 中国水产科学研究院珠江水产研究所 一种提高反季鱼苗成活率的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
NZ204074A (en) * 1982-05-10 1986-05-09 Merck & Co Inc Synergistic compositions containing avermectins
NZ207655A (en) * 1983-04-07 1986-09-10 Merck & Co Inc Synergistic veterinary compositions containing an avermectin compound and clorsulon
NZ210505A (en) * 1983-12-22 1988-06-30 Merck & Co Inc Parasiticidal compositions containing avermectin or milbemycin derivatives
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
EP0240274A3 (de) * 1986-04-03 1990-03-14 Merck & Co. Inc. Avermectin als wachstumsfördernde Mittel

Also Published As

Publication number Publication date
NO172446B (no) 1993-04-13
IE880159L (en) 1988-07-23
AR244344A1 (es) 1993-10-29
RU2096462C1 (ru) 1997-11-20
MA21161A1 (fr) 1988-10-01
AU603415B2 (en) 1990-11-15
CZ40888A3 (cs) 2000-08-16
DK28688A (da) 1988-07-24
MY102581A (en) 1992-07-31
DK175724B1 (da) 2005-02-07
KR900007937B1 (ko) 1990-10-23
EP0284176A2 (de) 1988-09-28
FI90087B (fi) 1993-09-15
JPH0817694B2 (ja) 1996-02-28
ES2058244T3 (es) 1994-11-01
NO880262L (no) 1988-07-25
CZ290312B6 (cs) 2002-07-17
FI880279A0 (fi) 1988-01-22
CA1338141C (en) 1996-03-12
NO172447C (no) 1993-07-21
NO880261L (no) 1988-07-25
AP53A (en) 1989-09-17
IL85119A0 (en) 1988-06-30
AU1069788A (en) 1988-07-28
CN1065277C (zh) 2001-05-02
AP8800077A0 (en) 1987-11-01
HUT48684A (en) 1989-06-28
FI90087C (fi) 1993-12-27
KR880009121A (ko) 1988-09-14
AU636709B2 (en) 1993-05-06
YU99090A (sh) 1992-07-20
DK28688D0 (da) 1988-01-22
IE62467B1 (en) 1995-02-08
HU203130B (en) 1991-05-28
PT86582A (en) 1988-02-01
NO172447B (no) 1993-04-13
IL85119A (en) 1993-01-14
EP0284176A3 (en) 1989-11-02
NO880261D0 (no) 1988-01-22
DE3883408T2 (de) 1993-12-09
NZ223270A (en) 1991-12-23
BG48572A3 (bg) 1991-03-15
EG18796A (en) 1994-09-29
NO880262D0 (no) 1988-01-22
YU47877B (sh) 1996-05-20
CN88100373A (zh) 1988-08-31
YU47886B (sh) 1996-05-20
YU10988A (en) 1990-02-28
EP0284176B1 (de) 1993-08-25
PT86582B (pt) 1991-12-31
AU7111391A (en) 1991-10-03
JPS6419093A (en) 1989-01-23
NO172446C (no) 1993-07-21
MX169293B (es) 1993-06-28
FI880279L (fi) 1988-07-24

Similar Documents

Publication Publication Date Title
DE3884973D1 (de) Verfahren zur Herstellung von Avermectine-B und die verwendeten Kulturen.
DE3883408D1 (de) Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.
DE3852724D1 (de) Verfahren zur Herstellung von mikroporösen Produkten und die so erhaltenen Produkte.
DE3784841D1 (de) Konfektprodukt und verfahren zur herstellung.
DE3789881D1 (de) Verfahren zur Herstellung von Photomasken und Photomaske.
DE3863170D1 (de) Mesophasenpech zur herstellung von kohlenstoffkoerpern und verfahren zur herstellung derselben.
DE3888507D1 (de) Verfahren zur Herstellung von gegossenen Produkten.
DE3853836D1 (de) Kontinuierliches Verfahren zur Herstellung von Äthylen-Propylen-Copolymeren.
ATE66678T1 (de) Verfahren zur herstellung von makrolidderivaten.
DE3689259D1 (de) Verfahren zur Herstellung von Polyolefinen.
DE3750318D1 (de) Verfahren zur Herstellung von Halosilanen.
DE68921655D1 (de) Verfahren zur Herstellung von Mustern.
DE3789557D1 (de) Verfahren zur Herstellung von Maleimid.
DE3851364D1 (de) Verfahren zur Herstellung von supraleitendem Material.
DE58906418D1 (de) Verfahren zur Herstellung von Festkörpern.
DE3853968D1 (de) Verfahren zur Herstellung von Vitronectin.
ATE86619T1 (de) Verfahren zur herstellung von nitroethenderivaten.
DE68910702D1 (de) Verfahren zur Herstellung von Silikongelsphären.
DE58906122D1 (de) Verfahren zur Herstellung von Phenylethanolen.
DE3884070D1 (de) Verfahren zur Herstellung von Harnstoffen.
DE3850151D1 (de) Verfahren zur Herstellung von Mustern.
DE3884324D1 (de) Verfahren zur Herstellung von menschlichen pro-apolipoprotein-A-I-ähnlichen Proteinen.
DE3852992D1 (de) Verfahren zur Herstellung von Hylan und Hylanverbindungen.
DE3862774D1 (de) Verfahren zur herstellung von vinylphosphonsaeuredialkylestern.
DE3886881D1 (de) Verfahren zur Herstellung von Polyacetylen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition