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DE3852033D1 - Follistatin und verfahren zur reinigung desselben. - Google Patents

Follistatin und verfahren zur reinigung desselben.

Info

Publication number
DE3852033D1
DE3852033D1 DE3852033T DE3852033T DE3852033D1 DE 3852033 D1 DE3852033 D1 DE 3852033D1 DE 3852033 T DE3852033 T DE 3852033T DE 3852033 T DE3852033 T DE 3852033T DE 3852033 D1 DE3852033 D1 DE 3852033D1
Authority
DE
Germany
Prior art keywords
porcine
rat
protein
residues
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3852033T
Other languages
English (en)
Other versions
DE3852033T2 (de
Inventor
Nicholas Ling
Naoto Ueno
Shunichi Shimasaki
Frederick Esch
Shao-Yao Ying
Roger Guillemin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of DE3852033D1 publication Critical patent/DE3852033D1/de
Publication of DE3852033T2 publication Critical patent/DE3852033T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3852033T 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben. Expired - Fee Related DE3852033T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin
PCT/US1988/002971 WO1989001945A1 (en) 1987-08-28 1988-08-26 Follistatin and method of purifying same

Publications (2)

Publication Number Publication Date
DE3852033D1 true DE3852033D1 (de) 1994-12-08
DE3852033T2 DE3852033T2 (de) 1995-04-27

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852033T Expired - Fee Related DE3852033T2 (de) 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben.

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
DE3853383T2 (de) * 1987-01-29 1995-07-27 Biotech Australia Pty Ltd Isolierung von einkettigen proteinen mit fsh unter- drückender aktivität aus follikularflüssigkeit.
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
ATE343635T1 (de) * 1993-05-12 2006-11-15 Genetics Inst Llc Bmp-11 zusammenstellungen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6686198B1 (en) 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
DE69434934D1 (de) * 1993-10-14 2007-04-12 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
CA2176942C (en) 1993-12-07 2011-11-01 Anthony J. Celeste Bmp-12, bmp-13 and tendon-inducing compositions thereof
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) * 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
ES2225241T3 (es) 1999-10-15 2005-03-16 Genetics Institute, Llc Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
DE60237194D1 (de) * 2001-03-02 2010-09-16 Activx Biosciences Inc Plattform für protein-profiling
ATE393573T1 (de) 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
IL159240A0 (en) * 2001-06-08 2004-06-01 Smith & Nephew Bmp binding proteins for use in bone or cartilage regeneration
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
AUPR638101A0 (en) 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
EP2053135A1 (de) * 2001-10-31 2009-04-29 Alcon, Inc. Morphogenetische Proteine (BMP), BMP-Rezeptoren und BMP-bindende Proteine und ihre Verwendung bei der Diagnose und Behandlung von Glaukomen
NZ546438A (en) 2003-09-12 2010-07-30 Wyeth Corp Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
CA2541237C (en) * 2003-10-06 2015-12-01 Monash University Modulation of activin to alter inflammatory responses
WO2008067480A2 (en) 2006-11-29 2008-06-05 Nationwide Children's Hospital Myostatin inhibition for enhancing muscle and/or improving muscle function
CA2729096C (en) 2008-06-26 2020-04-28 Acceleron Pharma Inc. Methods for dosing an actriib antagonist and monitoring of treated patients
CN108744262A (zh) 2010-11-23 2018-11-06 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
EA037979B1 (ru) 2012-02-27 2021-06-18 Амуникс Оперейтинг Инк. Композиции конъюгата xten и способы их получения
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
EP2883461B1 (de) * 2013-12-11 2017-11-08 Deutsches Institut für Lebensmitteltechnik e.V. Verfahren zur Herstellung von aktivem Follistatin
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
CN106795224B (zh) 2014-06-04 2021-05-18 阿塞勒隆制药公司 用促滤泡素抑制素多肽治疗病症的方法和组合物
JP2018510637A (ja) 2015-03-26 2018-04-19 アクセルロン ファーマ， インコーポレイテッド フォリスタチン関連融合タンパク質およびその使用
IL294072A (en) 2019-12-20 2022-08-01 Res Inst Nationwide Childrens Hospital Gene therapy is efficient for targeting muscle in muscle diseases
WO2024220592A2 (en) 2023-04-18 2024-10-24 Research Institute At Nationwide Children's Hospital, Inc. Gene therapy for treating limb girdle muscular dystrophy r9 and congenital muscular dystrophy 1c
WO2025188993A2 (en) 2024-03-07 2025-09-12 Research Institute At Nationwide Children's Hospital Gene therapy for treating gne-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
JP2709113B2 (ja) 1998-02-04
AU620346B2 (en) 1992-02-20
US5041538A (en) 1991-08-20
DE3852033T2 (de) 1995-04-27
CA1340972C (en) 2000-04-25
ATE113654T1 (de) 1994-11-15
WO1989001945A1 (en) 1989-03-09
AU2420088A (en) 1989-03-31
EP0377659B1 (de) 1994-11-02
JPH04504105A (ja) 1992-07-23
EP0377659A1 (de) 1990-07-18
EP0377659A4 (en) 1990-12-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee