DE3789039D1 - Verbrückte bicyclische N-heterocyclische Verbindungen. - Google Patents

Verbrückte bicyclische N-heterocyclische Verbindungen.

Info

Publication number: DE3789039D1
Authority: DE; Germany
Prior art keywords: heterocyclic compounds; bridged bicyclic; bicyclic; bridged; heterocyclic
Prior art date: 1986-06-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE87305586T

Other languages

English (en)

Other versions

DE3789039T2 (de

Inventor

Barry Sidney Orlek

Michael Stewart Hadley

Harry John Wadsworth

Howard Elliott Rosenberg

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee

Beecham Group PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-27

Filing date

1987-06-23

Publication date

1994-03-24

1986-06-27 Priority claimed from GB868615784A external-priority patent/GB8615784D0/en

1986-09-17 Priority claimed from GB868622380A external-priority patent/GB8622380D0/en

1987-06-23 Application filed by Beecham Group PLC filed Critical Beecham Group PLC

1994-03-24 Publication of DE3789039D1 publication Critical patent/DE3789039D1/de

1994-06-09 Application granted granted Critical

1994-06-09 Publication of DE3789039T2 publication Critical patent/DE3789039T2/de

2007-06-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DE3789039T 1986-06-27 1987-06-23 Verbrückte bicyclische N-heterocyclische Verbindungen. Expired - Fee Related DE3789039T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868615784A GB8615784D0 (en)	1986-06-27	1986-06-27	Compounds
GB868622380A GB8622380D0 (en)	1986-09-17	1986-09-17	Compounds

Publications (2)

Publication Number	Publication Date
DE3789039D1 true DE3789039D1 (de)	1994-03-24
DE3789039T2 DE3789039T2 (de)	1994-06-09

Family

ID=26290965

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3789039T Expired - Fee Related DE3789039T2 (de)	1986-06-27	1987-06-23	Verbrückte bicyclische N-heterocyclische Verbindungen.

Country Status (9)

Country	Link
US (1)	US4968691A (de)
EP (1)	EP0261763B1 (de)
JP (1)	JPH0757753B2 (de)
AU (2)	AU638400B2 (de)
DE (1)	DE3789039T2 (de)
DK (1)	DK324487A (de)
ES (1)	ES2061502T3 (de)
NZ (1)	NZ220841A (de)
PT (1)	PT85174B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8528633D0 (en) *	1985-11-21	1985-12-24	Beecham Group Plc	Compounds
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
DE3789039T2 (de) *	1986-06-27	1994-06-09	Beecham Group Plc	Verbrückte bicyclische N-heterocyclische Verbindungen.
ATE133415T1 (de) *	1987-04-15	1996-02-15	Beecham Group Plc	Am brückenkopf substituierte azabicyclenderivate
NZ226000A (en) *	1987-09-10	1991-06-25	Merck Sharp & Dohme	Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
EP0307141B1 (de) *	1987-09-10	1993-01-13	MERCK SHARP & DOHME LTD.	Oxazole und Thiazole zur Behandlung seniler Demenz
US5405853A (en) *	1987-09-10	1995-04-11	Merck Sharpe & Dohme Ltd.	Thiadiazoles useful in the treatment of senile dementia
US5324723A (en) *	1987-09-10	1994-06-28	Merck Sharpe & Dohme Ltd.	Oxazoles and thiazoles for the treatment of senile dementia
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
NZ227841A (en) *	1988-02-12	1991-08-27	Merck Sharp & Dohme	Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808433D0 (en) *	1988-04-11	1988-05-11	Merck Sharp & Dohme	Therapeutic agents
GB8808926D0 (en) *	1988-04-15	1988-05-18	Beecham Group Plc	Novel compounds
PT90266B (pt) *	1988-04-15	1994-07-29	Beecham Group Plc	Processo para a preparacao de compostos azabiciclicos
GB8816299D0 (en) *	1988-07-08	1988-08-10	Merck Sharp & Dohme	Therapeutic agents
EP0363085A3 (de)	1988-10-03	1991-03-27	Beecham Group Plc	Chemische Verbindungen
CA2000041A1 (en) *	1988-10-13	1990-04-13	Barry S. Orlek	Compounds
GB8830226D0 (en) *	1988-12-23	1989-02-22	Beecham Group Plc	Novel compounds
IT1229491B (it) *	1988-12-28	1991-09-03	Roussel Maestretti S P A Ora R	Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
SG48315A1 (en) *	1989-04-13	1998-04-17	Beecham Group Plc	Novel compounds
CA2016707A1 (en) *	1989-05-15	1990-11-15	Graham A. Showell	Process for resolving 1-azabicyclo[2.2.1]heptane-3-carboxylates
GB8911080D0 (en) *	1989-05-15	1989-06-28	Merck Sharp & Dohme	Chemical process
EP0402056A3 (de) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
GB8917957D0 (en) *	1989-08-05	1989-09-20	Beecham Group Plc	Novel compounds
DE69026197T2 (de) *	1989-10-07	1997-01-09	Beecham Group Plc	Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0456310A3 (en) *	1990-05-09	1992-03-04	Merck Sharp & Dohme Ltd.	Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
GB9017353D0 (en) *	1990-08-08	1990-09-19	Merck Sharp & Dohme	Chemical process
MX9100779A (es) *	1990-08-24	1992-04-01	Beecham Group Plc	Compuestos azabiciclicos y procedimiento para su preparacion
GB9019095D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
EP0552213A1 (de) *	1990-10-12	1993-07-28	Beecham Group Plc	1,2,5,6-tetrahydropyridinoximderivate
US5124460A (en) *	1991-05-06	1992-06-23	Merck Sharp & Dohme Ltd.	Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
CA2126976A1 (en) *	1991-12-31	1993-07-08	Hisashi Takasugi	Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
SE9201478D0 (sv) *	1992-05-11	1992-05-11	Kabi Pharmacia Ab	Heteroaromatic quinuclidinenes, their use and preparation
JP3474575B2 (ja) *	1993-08-19	2003-12-08	ノボノルディスクアクティーゼルスカブ	抗精神病方法
US5663182A (en) *	1993-08-19	1997-09-02	Bymaster; Franklin Porter	Antipsychotic method
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
JP2002500651A (ja)	1997-05-29	2002-01-08	ハー・ルンドベック・アクティーゼルスカブ	精神分裂病及び精神病の治療方法
EP1315493A4 (de) *	2000-08-21	2007-12-05	Univ Georgetown	2,3-Disubstituierte Chinuklidine as Monoamin-Transportermodulatoren und therapeutische und diagnostische Methoden, die darauf basieren.
EP2258358A3 (de)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenese mit Acetylcholinesterasehemmer
JP2009506069A (ja) *	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2287626B1 (de)	2006-06-13	2013-05-29	Kabushiki Kaisha Toshiba	Phasenkorrekturgerät, inbesondere für Doppler-VOR Antennenarray
MX2009002496A (es)	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2658067A (en) *		1953-11-03		Substituted carbamic acdj esters
US3501471A (en) *	1966-09-21	1970-03-17	American Cyanamid Co	Novel 2,3-heterocyclic fused quinuclidines,and 3-substituted quinuclidine-2-carboxylate derivatives
US3681363A (en) *	1970-08-20	1972-08-01	Univ Temple	Spiro(imidazolidine-4,3{40 -quinuclidine)-2,5-diones
SU495310A1 (ru) *	1974-03-05	1975-12-15	Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе	Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4038402A (en) *	1974-03-05	1977-07-26	Mikhail Emmanuilovich Kaminka	Method of effecting antihistaminic, antiserotonin and antiallergic actions
US4203990A (en) *	1979-04-30	1980-05-20	G. D. Searle & Co.	Anti-diarrheal 2-substituted quinuclidines
FR2526433B1 (fr) *	1982-05-04	1985-10-18	Pharmuka Lab	Isomeres dextrogyres de derives de l'aza-1 bicyclo (2,2,2) octane, leur procede de preparation et medicaments les contenant
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
DE3610977A1 (de) *	1986-04-02	1987-10-08	Weinig Michael Gmbh Co Kg	Vorrichtung zum wechseln von werkzeugen einer bearbeitungsmaschine, vorzugsweise einer holzbearbeitungsmaschine
DE3789039T2 (de) *	1986-06-27	1994-06-09	Beecham Group Plc	Verbrückte bicyclische N-heterocyclische Verbindungen.
AU620783B3 (en) *	1986-06-27	1992-01-09	Beecham Group Plc	1,2,4-oxadiazolyl-azabicyclo compounds
EP0307141B1 (de) *	1987-09-10	1993-01-13	MERCK SHARP & DOHME LTD.	Oxazole und Thiazole zur Behandlung seniler Demenz
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them

1987
- 1987-06-23 DE DE3789039T patent/DE3789039T2/de not_active Expired - Fee Related
- 1987-06-23 EP EP87305586A patent/EP0261763B1/de not_active Expired - Lifetime
- 1987-06-23 ES ES87305586T patent/ES2061502T3/es not_active Expired - Lifetime
- 1987-06-25 PT PT85174A patent/PT85174B/pt not_active IP Right Cessation
- 1987-06-25 DK DK324487A patent/DK324487A/da unknown
- 1987-06-25 NZ NZ220841A patent/NZ220841A/xx unknown
- 1987-06-25 AU AU74695/87A patent/AU638400B2/en not_active Ceased
- 1987-06-26 JP JP62159482A patent/JPH0757753B2/ja not_active Expired - Lifetime
1989
- 1989-03-07 US US07/320,707 patent/US4968691A/en not_active Expired - Fee Related
1991
- 1991-02-22 AU AU71318/91A patent/AU620307B3/en not_active Ceased

Also Published As

Publication number	Publication date
JPS6339876A (ja)	1988-02-20
AU7469587A (en)	1988-01-07
PT85174B (pt)	1990-03-30
EP0261763B1 (de)	1994-02-09
NZ220841A (en)	1990-08-28
AU620307B3 (en)	1991-12-17
DK324487D0 (da)	1987-06-25
DK324487A (da)	1987-12-28
AU638400B2 (en)	1993-07-01
US4968691A (en)	1990-11-06
AU7131891A (de)	1991-05-23
ES2061502T3 (es)	1994-12-16
EP0261763A1 (de)	1988-03-30
DE3789039T2 (de)	1994-06-09
JPH0757753B2 (ja)	1995-06-21
PT85174A (en)	1987-07-01

Publication	Publication Date	Title
DE3789039D1 (de)	1994-03-24	Verbrückte bicyclische N-heterocyclische Verbindungen.
FI874804A7 (fi)	1988-05-05	Bisykliset yhdisteet.
ATE62227T1 (de)	1991-04-15	Heterocyclische verbindungen.
DE3675422D1 (de)	1990-12-13	Lipoxygenasehemmende verbindungen.
ES2019932B3 (es)	1991-07-16	Compuestos macrolidos.
DE3888821D1 (de)	1994-05-05	Tricyclische Verbindungen.
FI871974A7 (fi)	1987-11-08	Yhdisteet.
DE3873936D1 (de)	1992-10-01	Lipoxygenasehemmende verbindungen.
DE3675421D1 (de)	1990-12-13	Lypoxygenasehemmende verbindungen.
FI853174A7 (fi)	1986-02-25	Bisykliset yhdisteet.
FI882394A7 (fi)	1988-05-20	Yhdisteet.
ATE118771T1 (de)	1995-03-15	Herzschützende tocopherolähnliche verbindungen.
DE3788928D1 (de)	1994-03-10	Chemische Verbindungen.
DE68907982D1 (de)	1993-09-09	Chemische verbindungen.
DE3764044D1 (de)	1990-09-06	Chirale verbindungen.
DE3682873D1 (de)	1992-01-23	Heterocyclische verbindungen.
ATE94537T1 (de)	1993-10-15	Arylpiperazinylalkylenphenylheterocyclische verbindungen.
DE3789720D1 (de)	1994-06-09	Cephalosporinverbindungen.
DE69105834D1 (de)	1995-01-26	Bicyclische Verbindungen.
FI874931A0 (fi)	1987-11-06	Anvaendning av alfa-2i-selektiva adrenergiska receptoragonister foer foerbaettrande av minnet.
DE3782702D1 (de)	1992-12-24	Vorlaeufer von antihypercholesterinaemischen verbindungen.
DE68915928D1 (de)	1994-07-14	Benzoheterozyklische Verbindungen.
DE3861252D1 (de)	1991-01-24	Antihypercholesterinaemische verbindungen.
ATE126217T1 (de)	1995-08-15	Phenoxyheterozyklische verbindungen.
FI870934A7 (fi)	1987-09-07	Penem-derivat.

Legal Events

Date	Code	Title	Description
1995-03-16	8364	No opposition during term of opposition
1998-06-10	8339	Ceased/non-payment of the annual fee