DE3331573A1 - Antimicrobial agent solution and moist cloth produced with the latter - Google Patents
Antimicrobial agent solution and moist cloth produced with the latterInfo
- Publication number
- DE3331573A1 DE3331573A1 DE19833331573 DE3331573A DE3331573A1 DE 3331573 A1 DE3331573 A1 DE 3331573A1 DE 19833331573 DE19833331573 DE 19833331573 DE 3331573 A DE3331573 A DE 3331573A DE 3331573 A1 DE3331573 A1 DE 3331573A1
- Authority
- DE
- Germany
- Prior art keywords
- alkoylamino
- active ingredient
- aqu
- oleum
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004744 fabric Substances 0.000 title claims description 6
- 239000004599 antimicrobial Substances 0.000 title abstract description 4
- SNKKBYWIYDOXGC-IYEMJOQQSA-N hexane;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound CCCCCC.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O SNKKBYWIYDOXGC-IYEMJOQQSA-N 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 230000000845 anti-microbial effect Effects 0.000 claims description 9
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 239000011888 foil Substances 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- 239000010642 eucalyptus oil Substances 0.000 abstract 1
- 229940044949 eucalyptus oil Drugs 0.000 abstract 1
- 239000010668 rosemary oil Substances 0.000 abstract 1
- 229940058206 rosemary oil Drugs 0.000 abstract 1
- 239000010670 sage oil Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 241000607534 Aeromonas Species 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000203233 Aspergillus versicolor Species 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000193155 Clostridium botulinum Species 0.000 description 1
- 241000186581 Clostridium novyi Species 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- 241001480037 Microsporum Species 0.000 description 1
- 241000893980 Microsporum canis Species 0.000 description 1
- 241000588772 Morganella morganii Species 0.000 description 1
- 241000378863 Mucor plumbeus Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000893976 Nannizzia gypsea Species 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 241000228150 Penicillium chrysogenum Species 0.000 description 1
- 240000000064 Penicillium roqueforti Species 0.000 description 1
- 235000002233 Penicillium roqueforti Nutrition 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000588777 Providencia rettgeri Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 241000235546 Rhizopus stolonifer Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000877401 Saccharomyces ellipsoideus Species 0.000 description 1
- 241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 1
- 241000607683 Salmonella enterica subsp. enterica serovar Pullorum Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000235350 Schizosaccharomyces octosporus Species 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 241001620697 Sporendonema Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000223261 Trichoderma viride Species 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 241001480048 Trichophyton tonsurans Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Die Erfindung betrifft eine antimikrobielle Wirkstoff- The invention relates to an antimicrobial active ingredient
lösung und mit dieser hergestelltes Feuchttuch.solution and wet wipe made with it.
Aufgabe der vorliegenden Erfindung ist es, ein pharmakologisches System mit einem breiten Wirkungsspektrum gegen eine große Anzahl von Mikroorganismen zu schaffen, das im Sinne eines Synergismus gegen grampositive und gramnegative Bakterien, sowie gegen Pilze, Hefen und Schimmel wirkt. The object of the present invention is to provide a pharmacological System with a broad spectrum of activity against a large number of microorganisms to create that in the sense of a synergism against gram-positive and gram-negative Bacteria, as well as fungi, yeast and mold.
Außerdem soll eine Wirkstofflösung geschaffen werden, die für präoperative Hautvorbereitungen geeignet ist, so auch bei ekzematösen Infektionen, besonders mykotischer Natur.In addition, an active ingredient solution is to be created that is suitable for preoperative Skin preparations are suitable, especially in the case of eczematous infections mycotic nature.
Zur Lösung dieser Aufgabe wird ein antimikrobiell wirksames Feuchttuch vorgeschlagen, welches erfindungsgemäß aus einem mit einer auf einen pH-Wert von etwa 6,15 eingestellten Wirkstofflösung aus 0,70 g N-Alkyl-N-benzyl-N,N-dimethylammoniumchlorid (50% aqu.), 0,25 g 1 , 6-Di- (N-p-chlorphenyldiguanid) -hexan-digluconat (20% aqu.), 2,50 g 1-Alkoylamino-3-dimethylammoniopropan-3-carboxymethylbetain, 2,50 g 1-Alkoylamino-3-dimethylaminopropan-3-N-oxid, 92,30 g Alcohol isopropylicus (70%), gegebenenfalls mit einem Zusatz von 0,50 g Oleum Rosmarini, 0,50 g Oleum Salviae, 0,75 g Oleum Eucalypti behandelten Wirkstoffträger aus einem Gewebe, Vlies od. dgl. An antimicrobial wet wipe is used to solve this problem proposed, which according to the invention from a with a to a pH of about 6.15 adjusted active ingredient solution from 0.70 g of N-alkyl-N-benzyl-N, N-dimethylammonium chloride (50% aqu.), 0.25 g 1,6-di- (N-p-chlorophenyl diguanide) -hexane digluconate (20% aqu.), 2.50 g 1-Alkoylamino-3-dimethylammoniopropane-3-carboxymethylbetaine, 2.50 g 1-Alkoylamino-3-dimethylaminopropane-3-N-oxide, 92.30 g Alcohol isopropylicus (70%), optionally with an addition of 0.50 g Oleum Rosmarini, 0.50 g Oleum Salviae, 0.75 g Oleum Eucalypti treated active ingredient carrier from a fabric, fleece or the like.
besteht, der in einer aufreißbaren Schutzumhüllung, aus Folie od. dgl. angeordnet ist.consists, which is in a tearable protective cover, made of foil or Like. Is arranged.
Des weiteren sieht die Erfindung zur Lösung der gestellten Aufgabe die Verwendung einer auf einen pH-Wert von etwa 6,15 eingestellten Wirkstofflösung aus 0,70 g N-Alkyl-N-benzylN,N-dimethylammoniumchlorid (50% aqu.), 0,25 g 1 , 6-Di- (N-p-chlorphenyldiguanid) -hexandigluconat (20% aqu.), 2,50 g 1-Alkoylamino-3-dimethylammoniopropan-3-carboxymethylbetain, 2,50 g 1 -Alkoylamino-3-dimethylaminopropan-3-N-oxid, 92,30 g Alcohol isopropylicus (70%), gegebenenfalls unter Zusatz von 0,50 g Oleum Rosmarini, 0,50 g Oleum Salviae, 0,75 g Oleum Eucalypti auf einem Wirkstoffträger, wie Gewebe, Vlies od. dgl., zur Herstellung eines Feuchttuches mit antimkrobieller Wirkung zur percutanen Applikation, insbesondere zur Hygiene, Flächendesinfektion, Infektionsprophylaxe, Intimpflege und Erste-Hilfe-Wundversorgung, vor. The invention also seeks to achieve the object set the use of an active ingredient solution adjusted to a pH of about 6.15 from 0.70 g of N-alkyl-N-benzylN, N-dimethylammonium chloride (50% aqu.), 0.25 g of 1,6-di- (N-p-chlorophenyl diguanide) -hexanedigluconate (20% aqu.), 2.50 g 1-Alkoylamino-3-dimethylammoniopropane-3-carboxymethylbetaine, 2.50 g 1-Alkoylamino-3-dimethylaminopropane-3-N-oxide, 92.30 g Alcohol isopropylicus (70%), optionally with the addition of 0.50 g oleum rosmarini, 0.50 g oleum salviae, 0.75 g of oleum eucalypti on an active ingredient carrier such as fabric, fleece or the like Production of a wet wipe with an antimcrobial effect for percutaneous application, especially for hygiene, surface disinfection, infection prophylaxis, intimate hygiene and first aid wound care.
Ferner wird die Aufgabe durch eine Wirkstofflösung gelöst, die erfindungsgemäß aus einer auf einen pH-Wert von etwa 6,15 eingestellten Lösung aus 0,70 g N-Alkyl-N-benzyl-N,N-dimethylammoniumchlorid (50% aqu.), 0,25 g 1, 6-Di- (N-p-chlorphenyldiguanid) --hexan-digluconat (20% aqu.), 2,50 g 1-Alkoylamino-3-dimethylammoniopropan-3-carboxymethylbetain, 2,50 g 1-Alkoylamino-3-dimethylaminopropan-3-N-oxid, 94,05 g Alcohol isopropylicus (70%), besteht. Furthermore, the object is achieved by an active ingredient solution according to the invention from a solution, adjusted to a pH of about 6.15, of 0.70 g of N-alkyl-N-benzyl-N, N-dimethylammonium chloride (50% aqu.), 0.25 g 1,6-di- (N-p-chlorophenyl diguanide) hexane digluconate (20% aqu.), 2.50 g 1-Alkoylamino-3-dimethylammoniopropane-3-carboxymethylbetaine, 2.50 g 1-Alkoylamino-3-dimethylaminopropane-3-N-oxide, 94.05 g Alcohol isopropylicus (70%).
überraschend hat es sich gezeigt, daß eine derartige Wirkstofflösung besonders wirksam bei präoperativen Hautvorbereitungen einsetzbar ist, so u.a. auch bei ekzematösen Infektionen, besonders mykotischer Natur. Surprisingly, it has been shown that such an active ingredient solution is particularly effective for preoperative skin preparations, including among others in eczematous infections, especially of a mycotic nature.
Des weiteren sieht die Erfindung eine Wirkstofflösung vor, die aus einer auf einen pH-Wert von etwa 6,15 eingestellten Lösung aus 0,70 g N-Alkyl-N-benzyl-N,N-dimethylammoniumchlorid (50% aqu.), 0,25 g 1,6-Di-(N-p-chlorphenyldiguanid)-hexan-digluconat (20% aqu.), 2,50 g 1-Alkoylamino-3-dimethylammoniopropan-3-carboxymethylbetain, 2,50 g 1-Alkoylamino-3-dimethylaminopropan-3-N-oxid, 92,30 g Alcohol isopropylicus (70%), 0,50 g Oleum Rosmarini, 0,50 g Oleum Salviae, 0,75 g Oleum Eucalypti besteht. The invention also provides an active ingredient solution that consists of a solution, adjusted to a pH of about 6.15, of 0.70 g of N-alkyl-N-benzyl-N, N-dimethylammonium chloride (50% aqu.), 0.25 g 1,6-di- (N-p-chlorophenyl diguanide) -hexane digluconate (20% aqu.), 2.50 g 1-Alkoylamino-3-dimethylammoniopropane-3-carboxymethylbetaine, 2.50 g 1-Alkoylamino-3-dimethylaminopropane-3-N-oxide, 92.30 g Alcohol isopropylicus (70%), 0.50 g Oleum Rosmarini, 0.50 g Oleum Salviae, 0.75 g of oleum eucalypti.
überraschend wurde aufgefunden, daß ein Feuchttuch mit der angegebenen Wirkstofflösung sich besonders zur Personal-Hygiene, Flächendesinfektion, Infektionsprophylaxe,- Intimpflege, Desinfektion von Gegenständen und Erste-Hilfe-Wundversorgung hervorragend eignet, da das geschaffene pharmakologische System mit einem breiten Wirkungsspektrum gegen eine große Anzahl von Mikroorganismen wirksam ist. Die zum Einsatz kommenden antimikrobiellen Substanzen wirken im Sinne eines Synergismus gegen grampositive und gramnegative Bakterien, sowie gegen Pilze, Hefen und Schimmel. Die Galenik der verwendeten Wirkstofflösung zeichnet sich dadurch aus, daß die antimikrobiellen Komponenten zusammen mit wirkspezifisch angepaßten ampholytischen Tensiden in einem Hydro-Alkohol-Vehicel dargestellt sind. It was surprisingly found that a wet wipe with the specified Active ingredient solution is particularly suitable for personal hygiene, surface disinfection, infection prophylaxis, Intimate hygiene, disinfection of objects and first aid wound care are excellent suitable because the pharmacological system created has a broad spectrum of activity against a big one Number of microorganisms is effective. The for Antimicrobial substances used act in the sense of a synergism against gram-positive and gram-negative bacteria, as well as against fungi, yeast and mold. The galenics of the active ingredient solution used is characterized by the fact that the antimicrobial Components together with ampholytic surfactants adapted for specific effects in one Hydro-alcohol vehicles are shown.
Das dem Feuchttuch zugrundeliegende pharmakologische System ist u.a. wirksam gegen: Grampositive Bakterien: Bacillus subtilis Bacillus cereus Bacillus megaterium Clostridium welchii Clostridium novyi Clostridium tetani Clostridium botulinum Clostridium perfringens Corynebacterium diphtherioe Corynebacterium acnes Mycobacterium tuberculosis Sarcina lutea Staphylococcus aureus Staphylococcus albus Staphylococcus epidermidis Streptococcus pyogenes Streptococcus faecalis Streptococcus mutans Streptococcus lactis Streptococcus pneumoniae Gramnegative Bakterien: Aeromonas aerogenes Enterobacter cloacae Escherichia coli Klebsiella aerogenes Klebsiella pneumoniae Proteus mirabilis Proteus morgani Proteus vulgaris Proteus rettgeri Pseudomonas fluorescens Pseudomonas aeruginosa Salmonella dublin Salmonella typhi Salmonella typhosa Salmonella pullorum Salmonella typhimurium Serratia marcescens Shigella flexneri Shigella sonnei Vivrio cholera Hefen und Dermatophyten: Candida albicans Microsporum audouini Microsporum gypseum Microsporum canis Saccharomyces cerecisiae Saccharomyces ellipsoideus Schizosaccharomyces octosporus Schizosaccharomyces pombe Trichophyton mentagrophytes Trichophyton tons uran Schimmel: Aspergillus versicolor Mucor plumbeus Penicillium notatum Penicillium roqueforti Rhizopus nigricans Sporendonema sp. The pharmacological system on which the wet wipe is based is i.a. effective against: Gram-positive bacteria: Bacillus subtilis Bacillus cereus Bacillus megaterium Clostridium welchii Clostridium novyi Clostridium tetani Clostridium botulinum Clostridium perfringens Corynebacterium diphtherioe Corynebacterium acnes Mycobacterium tuberculosis Sarcina lutea Staphylococcus aureus Staphylococcus albus Staphylococcus epidermidis Streptococcus pyogenes Streptococcus faecalis Streptococcus mutans Streptococcus lactis Streptococcus pneumoniae gram negative Bacteria: Aeromonas aerogenes Enterobacter cloacae Escherichia coli Klebsiella aerogenic Klebsiella pneumoniae Proteus mirabilis Proteus morgani Proteus vulgaris Proteus rettgeri Pseudomonas fluorescens Pseudomonas aeruginosa Salmonella dublin Salmonella typhi Salmonella typhosa Salmonella pullorum Salmonella typhimurium Serratia marcescens Shigella flexneri Shigella sonnei Vivrio cholera yeasts and dermatophytes: Candida albicans Microsporum audouini Microsporum gypseum Microsporum canis Saccharomyces cerecisiae Saccharomyces ellipsoideus Schizosaccharomyces octosporus Schizosaccharomyces pombe Trichophyton mentagrophytes Trichophyton tons uran mold: Aspergillus versicolor Mucor plumbeus Penicillium notatum Penicillium roqueforti Rhizopus nigricans Sporendonema sp.
Trichoderma viride Das erfindungsgemäß verwendete pharmakologische System zeichnet sich ferner durch äußerst geringe resorptive und orale Toxizität aus; es gewährleistet eine hohe Sicherheit im klinischen und ambulanten Gebrauch. Die dermatologisch-physiologischen Vorteile, insbesondere gegenüber Zubereitungen auf der Basis von Phenolen bzw. Phenolderivaten sind gekennzeichnet durch geringe Irritationsraten. Die ausgezeichnete Haut- und Schleimhautverträgliehkeit ist auch bei einem längeren Gebrauch und häufiger Anwendung gegeben. Chemisch und physikalisch ist die verwendete Wirkstofflösung stabil; sie besitzt ausgezeichnete Waschaktivität bei gutem Schmutztragevermögen und ist darüber hinaus wirtschaftlich darzustellen und in der Anwendung wirtschaftlich. Als Hautdesinfiziens für vielfältige Indikationsbereiche und Applikationstechniken im klinischen Sektor und im persönlich-hygie- nischen Sektor ist die Wirkstofflösung geeignet. Eine besonders relevante Ausbildungsform stellt dabei das mit der Wirkstofflösung getränkte und in einem Aluminium-Potymer-Verbundfolienbeutel versiegelte autosterile Tupfersystem dar. Die Wirkstofflösung ist aufbringbar auf de verschiedensten Arten von Wirkstoffträgern, wie Gewebe, Vliese, Schwämmchen, Tupfer, Wundkissenpolster und auch eine Verwendung in Sprühflaschen ist möglich. Trichoderma viride The pharmacological used according to the invention System is also characterized by extremely low absorptive and oral toxicity the end; it ensures a high level of safety in clinical and outpatient use. The dermatological-physiological advantages, especially compared to preparations based on phenols or phenol derivatives are characterized by low Irritation rates. The excellent skin and mucous membrane tolerance is also given with prolonged use and frequent use. Chemically and physically the active ingredient solution used is stable; it has excellent washing activity with good dirt-carrying capacity and can also be presented economically and economical to use. As a skin disinfectant for a wide range of indications and application techniques in the clinical sector and in personal hygiene niches The active ingredient solution is suitable for the sector. A particularly relevant form of training puts the soaked with the active ingredient solution in an aluminum-Potymer-composite foil bag sealed autosterile swab system. The active ingredient solution can be applied to de various types of active ingredient carriers, such as fabrics, fleeces, sponges, Swabs, wound pillow pads and also use in spray bottles are possible.
In denjenigen Fällen, in denen die Wirkstofflösung keine Zusätze von 0,50 g Oleum Rosmarini, 0,50 g Oleum Salviae und 0,75 g Oleum Eucalypti enthält, beträgt der Anteil an Alcohol isopropylicus 94,05 g. In those cases in which the active ingredient solution does not have any additives contains 0.50 g oleum rosmarini, 0.50 g oleum salviae and 0.75 g oleum eucalypti, the proportion of Alcohol isopropylicus is 94.05 g.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833331573 DE3331573A1 (en) | 1983-09-01 | 1983-09-01 | Antimicrobial agent solution and moist cloth produced with the latter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833331573 DE3331573A1 (en) | 1983-09-01 | 1983-09-01 | Antimicrobial agent solution and moist cloth produced with the latter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3331573A1 true DE3331573A1 (en) | 1985-03-21 |
Family
ID=6208009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19833331573 Withdrawn DE3331573A1 (en) | 1983-09-01 | 1983-09-01 | Antimicrobial agent solution and moist cloth produced with the latter |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3331573A1 (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3528209A1 (en) * | 1984-08-07 | 1986-04-24 | Fresenius AG, 6380 Bad Homburg | Disinfectant |
| DE3619748A1 (en) * | 1986-06-12 | 1987-12-17 | Merz & Co Gmbh & Co | ANTIMICROBIAL AGENTS |
| FR2686221A1 (en) * | 1992-01-22 | 1993-07-23 | Hutchinson | Compositions based on antiseptics and their applications |
| EP0555116A3 (en) * | 1992-01-22 | 1993-10-06 | Hutchinson | Compositions based on antiseptics and their applications |
| FR2690457A1 (en) * | 1992-02-11 | 1993-10-29 | Delory Christian | Liq. for cleaning, degreasing, disinfecting and deodorising headgear - contains ethanol@ soln. of chlorhexidine di-gluconate, benzalkonium chloride, shampoo and perfumed deodorant, used esp. for motorcycle helmets |
| FR2691325A1 (en) * | 1992-05-21 | 1993-11-26 | Hutchinson | Synergistic antiseptic compsns. |
| WO1997031093A1 (en) * | 1996-02-23 | 1997-08-28 | The Procter & Gamble Company | Disinfecting compositions |
| WO1997031092A1 (en) * | 1996-02-23 | 1997-08-28 | The Procter & Gamble Company | Disinfecting compositions and processes for disinfecting surfaces |
| FR2752731A1 (en) * | 1996-08-28 | 1998-03-06 | Pioch Michel | Antiseptic compositions for use in dentistry |
| WO1999064083A1 (en) * | 1998-06-11 | 1999-12-16 | Mcneil-Ppc, Inc. | Disposable absorbent article containing an essential oil |
| US6010993A (en) * | 1996-02-23 | 2000-01-04 | The Procter & Gamble Company | Disinfecting compositions |
| FR2792532A1 (en) * | 1999-04-26 | 2000-10-27 | Menarini France Lab | Compositions containing a synergistic mixture of benzalkonium salt and chlorhexidine salt, having antiseptic properties |
| US6328811B1 (en) | 1994-02-28 | 2001-12-11 | Incline Technologies, Inc. | Methods and systems for cleansing the skin |
-
1983
- 1983-09-01 DE DE19833331573 patent/DE3331573A1/en not_active Withdrawn
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3528209A1 (en) * | 1984-08-07 | 1986-04-24 | Fresenius AG, 6380 Bad Homburg | Disinfectant |
| DE3619748A1 (en) * | 1986-06-12 | 1987-12-17 | Merz & Co Gmbh & Co | ANTIMICROBIAL AGENTS |
| FR2686221A1 (en) * | 1992-01-22 | 1993-07-23 | Hutchinson | Compositions based on antiseptics and their applications |
| EP0555116A3 (en) * | 1992-01-22 | 1993-10-06 | Hutchinson | Compositions based on antiseptics and their applications |
| FR2690457A1 (en) * | 1992-02-11 | 1993-10-29 | Delory Christian | Liq. for cleaning, degreasing, disinfecting and deodorising headgear - contains ethanol@ soln. of chlorhexidine di-gluconate, benzalkonium chloride, shampoo and perfumed deodorant, used esp. for motorcycle helmets |
| FR2691325A1 (en) * | 1992-05-21 | 1993-11-26 | Hutchinson | Synergistic antiseptic compsns. |
| US6328811B1 (en) | 1994-02-28 | 2001-12-11 | Incline Technologies, Inc. | Methods and systems for cleansing the skin |
| WO1997031093A1 (en) * | 1996-02-23 | 1997-08-28 | The Procter & Gamble Company | Disinfecting compositions |
| US6010993A (en) * | 1996-02-23 | 2000-01-04 | The Procter & Gamble Company | Disinfecting compositions |
| WO1997031092A1 (en) * | 1996-02-23 | 1997-08-28 | The Procter & Gamble Company | Disinfecting compositions and processes for disinfecting surfaces |
| FR2752731A1 (en) * | 1996-08-28 | 1998-03-06 | Pioch Michel | Antiseptic compositions for use in dentistry |
| WO1999064083A1 (en) * | 1998-06-11 | 1999-12-16 | Mcneil-Ppc, Inc. | Disposable absorbent article containing an essential oil |
| US6284261B1 (en) | 1998-06-11 | 2001-09-04 | Mcneil-Ppc, Inc. | Disposable absorbent article containing an essential oil |
| FR2792532A1 (en) * | 1999-04-26 | 2000-10-27 | Menarini France Lab | Compositions containing a synergistic mixture of benzalkonium salt and chlorhexidine salt, having antiseptic properties |
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