DE3160084D1 - Novel erythromycin compounds - Google Patents
Novel erythromycin compoundsInfo
- Publication number
- DE3160084D1 DE3160084D1 DE8181302328T DE3160084T DE3160084D1 DE 3160084 D1 DE3160084 D1 DE 3160084D1 DE 8181302328 T DE8181302328 T DE 8181302328T DE 3160084 T DE3160084 T DE 3160084T DE 3160084 D1 DE3160084 D1 DE 3160084D1
- Authority
- DE
- Germany
- Prior art keywords
- novel erythromycin
- erythromycin compounds
- compounds
- novel
- erythromycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7525880A JPS572298A (en) | 1980-06-04 | 1980-06-04 | Erythromycin derivative |
| JP55159128A JPS5782400A (en) | 1980-11-12 | 1980-11-12 | Erythromycin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3160084D1 true DE3160084D1 (en) | 1983-03-31 |
Family
ID=26416408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8181302328T Expired DE3160084D1 (en) | 1980-06-04 | 1981-05-27 | Novel erythromycin compounds |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4331803A (de) |
| EP (1) | EP0041355B1 (de) |
| DE (1) | DE3160084D1 (de) |
| NL (1) | NL930083I2 (de) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5896097A (ja) * | 1981-12-01 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンb誘導体 |
| JPS5896098A (ja) * | 1981-12-03 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンa誘導体 |
| JPS60120895A (ja) * | 1983-12-02 | 1985-06-28 | Taisho Pharmaceut Co Ltd | 6−0−メチル−2′−0,ν−ビス(ベンジルオキシカルボニル)−ν−デメチルエリスロマイシンaの製法 |
| JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシン類の製法 |
| IL75908A0 (en) * | 1984-08-31 | 1985-12-31 | Abbott Lab | Macrolide alkylation process |
| JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシンa誘導体 |
| GB8506380D0 (en) * | 1985-03-12 | 1985-04-11 | Beecham Group Plc | Chemical compounds |
| HUT42502A (en) | 1985-03-12 | 1987-07-28 | Beecham Group Plc | Process for preparing new erythromycine derivatives |
| US4670549A (en) * | 1985-03-18 | 1987-06-02 | Taisho Pharmaceutical Co., Ltd. | Method for selective methylation of erythromycin a derivatives |
| JPS61229895A (ja) * | 1985-04-03 | 1986-10-14 | Nippon Zeon Co Ltd | 保護化デス−n−メチルエリスロマイシン誘導体 |
| US5175150A (en) * | 1985-08-31 | 1992-12-29 | Kitasato, Kenkyusho | Erythromycin derivative |
| US4672056A (en) * | 1985-11-12 | 1987-06-09 | Abbott Laboratories | Erythromycin A derivatives and method of use |
| US4640910A (en) * | 1985-11-12 | 1987-02-03 | Abbott Laboratories | Erythromycin A silylated compounds and method of use |
| US5149639A (en) * | 1986-03-24 | 1992-09-22 | Abbott Laboratories | Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production |
| US4874748A (en) * | 1986-03-24 | 1989-10-17 | Abbott Laboratories | Cloning vectors for streptomyces and use thereof in macrolide antibiotic production |
| JPS63107994A (ja) * | 1986-05-02 | 1988-05-12 | Taisho Pharmaceut Co Ltd | エリスロマイシン誘導体 |
| JPH0633312B2 (ja) * | 1986-05-02 | 1994-05-02 | 大正製薬株式会社 | 14−ハイドロキシエリスロマイシン誘導体およびその製造方法 |
| US4740502A (en) * | 1986-06-20 | 1988-04-26 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
| EP0260938B1 (de) | 1986-09-18 | 1992-12-09 | Taisho Pharmaceutical Co. Ltd | Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung |
| US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
| US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| HRP930014A2 (en) * | 1993-01-08 | 1994-08-31 | Pliva Pharm & Chem Works | 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates |
| CA2189001A1 (en) * | 1994-04-26 | 1995-11-02 | Nobuhiro Narita | Medicinal composition as a remedy for nonsmall cell lung cancer |
| US5498424A (en) * | 1994-11-30 | 1996-03-12 | Klein; Ira | Method of treating obesity |
| US5747466A (en) * | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
| US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
| US5756473A (en) * | 1995-11-21 | 1998-05-26 | Abbott Laboratories | 6-O-methyl erythromycin D and process for making |
| US5858986A (en) | 1996-07-29 | 1999-01-12 | Abbott Laboratories | Crystal form I of clarithromycin |
| US5844105A (en) * | 1996-07-29 | 1998-12-01 | Abbott Laboratories | Preparation of crystal form II of clarithromycin |
| DE97934319T1 (de) | 1996-07-29 | 2004-08-26 | Abbott Laboratories, Abbott Park | Herstellung von kristallinen form ii von clarithromycin |
| US5804565A (en) * | 1996-09-24 | 1998-09-08 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
| WO1998023628A1 (fr) | 1996-11-27 | 1998-06-04 | Taisho Pharmaceutical Co., Ltd. | Derives de l'erythromicine a |
| US5945405A (en) * | 1997-01-17 | 1999-08-31 | Abbott Laboratories | Crystal form O of clarithromycin |
| US5864023A (en) * | 1997-02-13 | 1999-01-26 | Abbott Laboratories | 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives |
| US6165986A (en) * | 1997-03-10 | 2000-12-26 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
| US6140479A (en) * | 1997-03-24 | 2000-10-31 | Taisho Pharmaceuticals Co., Ltd. | Erythromycin a derivatives |
| US5929219A (en) * | 1997-09-10 | 1999-07-27 | Abbott Laboratories | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
| US6174865B1 (en) | 1997-09-25 | 2001-01-16 | Ira Klein | Method of treating hypertriglyceridemia with an erythromycin compound |
| US5780604A (en) * | 1997-09-26 | 1998-07-14 | Abbott Laboratories | 11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides |
| WO1999021868A1 (fr) | 1997-10-29 | 1999-05-06 | Taisho Pharmaceutical Co., Ltd. | Derives d'erythromycine a |
| US5852180A (en) * | 1997-11-17 | 1998-12-22 | Abbott Laboratories | Chemical synthesis of 6-O-alkyl erythromycin A |
| IL135792A0 (en) * | 1997-12-01 | 2001-05-20 | Abbott Lab | 6-o-alkyl derivatives of erythronolide b |
| US5892008A (en) * | 1997-12-16 | 1999-04-06 | Abbott Laboratories | Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives |
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| HRP980189B1 (en) * | 1998-04-06 | 2004-04-30 | Pliva Pharm & Chem Works | Novel 15-membered lactams ketolides |
| SI20150A (sl) * | 1999-02-19 | 2000-08-31 | Lek, Tovarna Farmacevtskih In | Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina |
| CN1351608A (zh) * | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13-甲基红霉素衍生物 |
| US6420535B1 (en) | 1999-06-07 | 2002-07-16 | Abbott Laboratories | 6-O-carbamate ketolide derivatives |
| US6417366B2 (en) | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
| US6437106B1 (en) | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| GB9915745D0 (en) * | 1999-07-06 | 1999-09-08 | Biochemie Sa | Organic compounds |
| US6569836B2 (en) | 1999-12-02 | 2003-05-27 | Abbott Laboratories | 6-O-alkyl-2-nor-2-substituted ketolide derivatives |
| US6627743B1 (en) | 1999-12-03 | 2003-09-30 | Abbott Laboratories | 6-O-methylerythromycin A crystal form III |
| SK8322002A3 (en) * | 1999-12-16 | 2003-02-04 | Teva Pharma | Processes for preparing clarithromycin polymorphs and novel polymorph IV |
| RU2002118308A (ru) * | 2000-01-11 | 2004-02-20 | Тева Фамэситикл Индастрис Лтд. (Il) | Способы получения полиморфных модификаций кларитромицина |
| US6946446B2 (en) | 2000-02-24 | 2005-09-20 | Abbott Laboratories | Anti-infective agents useful against multidrug-resistant strains of bacteria |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| HRP20020709A2 (en) * | 2000-02-29 | 2004-12-31 | Teva Pharma | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
| US6605707B1 (en) | 2000-03-23 | 2003-08-12 | Abbott Laboratories | Process for the preparation of 6-O-propargyl erythromycin derivatives |
| DE60138876D1 (de) * | 2000-03-28 | 2009-07-16 | Sandoz Ag | Geschmackmaskierte granulierte teilchen |
| TR200401093T4 (tr) | 2000-05-15 | 2004-11-22 | Ranbaxy Laboratories, Ltd. | Eritromisin türevlerinin selektif metilasyonu için maliyet etkin bir metot |
| CA2419873A1 (en) | 2000-08-23 | 2002-02-28 | Wockhardt Limited | Process for preparation of anhydrous azithromycin |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6455680B1 (en) | 2000-12-21 | 2002-09-24 | Abbott Laboratories | Methods utilizing aryl thioimines in synthesis of erythromycin derivatives |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| TWI246515B (en) | 2001-05-30 | 2006-01-01 | Abbott Lab | An arylation method for the functionalization of O-allyl erythromycin derivatives |
| BR0212259A (pt) * | 2001-08-29 | 2004-10-19 | Ranbaxy Lab Ltd | Formulação de liberação controlada de claritromicina ou tinidazol |
| US20030091627A1 (en) * | 2001-10-31 | 2003-05-15 | Vinay Sharma | Rate-controlled delivery of macrolides |
| AU2003211923A1 (en) * | 2002-02-13 | 2003-09-04 | Taisho Pharmaceutical Co., Ltd. | Process for producing erythromycin a derivative |
| EP1490090A4 (de) | 2002-02-22 | 2006-09-20 | New River Pharmaceuticals Inc | Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen |
| AU2003214506A1 (en) * | 2002-04-03 | 2003-10-13 | Ranbaxy Laboratories Limited | Clarithromycin formulations having improved bioavailability |
| US6843854B2 (en) | 2002-05-31 | 2005-01-18 | Purdue Research Foundation | Method and apparatus for separating a component from a mixture |
| WO2004080391A2 (en) * | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
| US7435805B2 (en) | 2003-05-30 | 2008-10-14 | Glaxpsmithkline Istrazivacki | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
| CA2530581A1 (en) * | 2003-06-23 | 2005-01-06 | Auspex Pharmaceuticals | Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders |
| CA2533358C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8313775B2 (en) | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| JP2006528189A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
| JP2007502296A (ja) | 2003-08-11 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | ロバストペレット |
| WO2005016278A2 (en) | 2003-08-12 | 2005-02-24 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| EP1658034A4 (de) | 2003-08-29 | 2011-06-22 | Middlebrook Pharmaceuticals Inc | Antibiotisches produkt, seine verwendung und formulierung |
| US8460710B2 (en) | 2003-09-15 | 2013-06-11 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| AU2003263482A1 (en) * | 2003-09-25 | 2005-04-14 | Ranbaxy Laboratories Limited | 3'-n-substituted-3-o-substituted erythronolide a derivatives |
| CA2572292A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| US20060111560A1 (en) * | 2004-11-01 | 2006-05-25 | Glenmark Pharmaceuticals Limited | Process for the preparation of crystalline form II of clarithromycin |
| HRP20100253T1 (hr) | 2004-12-21 | 2010-06-30 | Pfizer Products Inc. | Makrolidi |
| US7582611B2 (en) | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| US20060293261A1 (en) * | 2005-06-24 | 2006-12-28 | Taisho Pharmaceutical Co., Ltd. | Clarithromycin or a salt thereof for the treatment or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli |
| US20070015719A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International Limited | Nanoparticulate clarithromycin formulations |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8299052B2 (en) * | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| EP2023721A2 (de) * | 2006-06-05 | 2009-02-18 | Auspex Pharmaceuticals Inc. | Herstellung und verwendung substituierter erythromycin-analoge |
| JP2010501541A (ja) | 2006-08-24 | 2010-01-21 | ウォックハート リサーチ センター | 抗菌活性を有する新規マクロライド及びケトライド |
| US20090054634A1 (en) * | 2007-08-09 | 2009-02-26 | Vinod Kumar Kansal | Process for the preparation of clarithromycin |
| US20090069255A1 (en) * | 2007-09-11 | 2009-03-12 | Protia, Llc | Deuterium-enriched clarithromycin |
| US9453042B2 (en) * | 2007-10-25 | 2016-09-27 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| CN102245195B (zh) | 2008-10-24 | 2016-01-13 | 森普拉制药公司 | 使用含三唑的大环内酯的生物防御 |
| CN101875678B (zh) * | 2009-04-30 | 2012-06-27 | 浙江华义医药有限公司 | 一种制备克拉霉素的方法 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| CN102724874B (zh) | 2009-09-10 | 2018-06-01 | 森普拉制药公司 | 治疗疟疾、结核病和mac疾病的方法 |
| PL2550286T3 (pl) | 2010-03-22 | 2016-07-29 | Cempra Pharmaceuticals Inc | Krystaliczne postaci makrolidu i ich zastosowanie |
| CN102250173B (zh) * | 2010-05-18 | 2015-07-08 | 上海医药工业研究院 | 一种6-o-甲基红霉素a衍生物和克拉霉素的制备方法 |
| CN102250180B (zh) * | 2010-05-18 | 2015-07-22 | 上海医药工业研究院 | 2’,4”-o-二(三甲基硅基)-红霉素a衍生物和克拉霉素制备方法 |
| CA2799937A1 (en) | 2010-05-20 | 2011-11-24 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| JP6042334B2 (ja) | 2010-09-10 | 2016-12-14 | センプラ ファーマシューティカルズ,インコーポレイテッド | 疾患治療のための水素結合形成フルオロケトライド |
| KR101657751B1 (ko) | 2010-12-09 | 2016-09-19 | 욱크하르트 리미티드 | 케토라이드 화합물 |
| WO2012117357A2 (en) | 2011-03-01 | 2012-09-07 | Wockhardt Limited | Process for preparation of ketolide intermediates |
| CN103619863B (zh) | 2011-03-22 | 2016-03-16 | 沃克哈特有限公司 | 酮内酯化合物的制备方法 |
| SG11201405895UA (en) | 2012-03-27 | 2014-10-30 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
| EP2671571A1 (de) | 2012-06-05 | 2013-12-11 | Sanovel Ilac Sanayi ve Ticaret A.S. | Formulierungen von Clarithromycin mit gesteuerter Freisetzung |
| MD20150056A2 (ro) | 2012-12-24 | 2015-09-30 | Ramot At Tel-Aviv University Ltd | Agenţi pentru tratarea bolilor genetice cauzate de mutaţii nonsens şi metode de identificare a acestora |
| RU2015138796A (ru) | 2013-03-14 | 2017-04-19 | Семпра Фармасьютикалс, Инк. | Способы и составы для лечения респираторных заболеваний |
| HK1218864A1 (zh) | 2013-03-15 | 2017-03-17 | 森普拉制药公司 | 用於制备大环内酯抗菌剂的收敛方法 |
| CN105801642B (zh) * | 2016-03-11 | 2019-03-26 | 北京理工大学 | 一种制备6,11-双-o-甲基红霉素a的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2653899A (en) * | 1952-04-14 | 1953-09-29 | Lilly Co Eli | Erythromycin, its salts, and method of preparation |
| US3674773A (en) * | 1970-10-06 | 1972-07-04 | Abbott Lab | Erythromycin derivatives |
| US3923784A (en) * | 1973-09-10 | 1975-12-02 | Hoffmann La Roche | Erythromycin a derivatives |
-
1981
- 1981-05-19 US US06/266,060 patent/US4331803A/en not_active Expired - Lifetime
- 1981-05-27 DE DE8181302328T patent/DE3160084D1/de not_active Expired
- 1981-05-27 EP EP81302328A patent/EP0041355B1/de not_active Expired
-
1993
- 1993-06-21 NL NL930083C patent/NL930083I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0041355A1 (de) | 1981-12-09 |
| EP0041355B1 (de) | 1983-02-23 |
| NL930083I1 (nl) | 1993-09-16 |
| NL930083I2 (nl) | 1994-12-01 |
| US4331803A (en) | 1982-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| V448 | Application of spc |
Free format text: PRODUCT NAME: CLARITHROMYCIN; REGISTRATION NO/DATE: 19219.00.00, 19901031 Spc suppl protection certif: 193 75 096 Filing date: 19930701 Free format text: PRODUCT NAME: CLARITHROMYCIN + KALIUMSORBAT; REGISTRATION NO/DATE: 19219.00.01, 19911031 Spc suppl protection certif: 193 75 098 Filing date: 19930701 |
|
| V457 | Spc granted |
Free format text: PRODUCT NAME: CLARITHROMYCIN; REGISTRATION NO/DATE: 19219.00.00, 19901031 Spc suppl protection certif: 193 75 096 Filing date: 19930701 |
|
| V472 | Application for supplementary protection certificate rejected |
Free format text: PRODUCT NAME: CLARITHROMYCIN + KALIUMSORBAT; REGISTRATION NO/DATE: 19219.00.01, 19911031 Spc suppl protection certif: 193 75 098 Filing date: 19930701 |
|
| V507 | Internal change in the state of proceedings of spc, spc applied |
Free format text: PRODUCT NAME: CLARITHROMYCIN + KALIUMSORBAT; REGISTRATION NO/DATE: 19219.00.01, 19911031 Spc suppl protection certif: 193 75 098 Filing date: 19930701 |
|
| V472 | Application for supplementary protection certificate rejected |
Free format text: PRODUCT NAME: CLARITHROMYCIN + KALIUMSORBAT; REGISTRATION NO/DATE: 19219.00.01, 19911031 Spc suppl protection certif: 193 75 098 Filing date: 19930701 |
|
| V464 | Spc expired |
Free format text: PRODUCT NAME: CLARITHROMYCIN; REGISTRATION NO/DATE: 19219.00.00, 19901031 Spc suppl protection certif: 193 75 096 Filing date: 19930701 |