DE29803260U1 - Food supplement for the universal restoration of disturbed homeostases - Google Patents

Description

Description of claim 2:

The normal acid-base balance is continually in danger of being disturbed by .

1.) the acids ingested with food - especially sulphur-containing amino acids and organophosphoric acids, from which sulphate and phosphate residues are formed in the metabolism -,

2.) carbonic acid (CO2) produced as an end product of metabolism - 13000 to 15000 mmol daily -

Kidneys and lungs constantly try to counteract these metabolic challenges and the body's own buffer systems - CO2/HCO3, phosphate, protein and intracellular-extracellular ion shifts (2 (2), anion gap) moderate the equilibrium-disrupting effects of the increase or decrease in the proton concentration (2 (18) , p. 771).

The possible causes of acid-base disorders can be seen from the foregoing alone:

1.) Kidney dysfunction (leading to renal acidosis (2 (3, 9, 11, 18, p.845 ff), hypo-, hyper-aldosteronism (2 (18, p. 279f) )

{That's why my homeostat contains citrates, diuretics and glutamine} . . .

2.) Malfunction of the lungs (leads to respiratory acidosis and alkalosis) (2 (6, 7, 18 p. 915) ) {That is why my homeostat contains substances that promote breathing and lung protection groups}

3.) Metabolic diseases that lead to the accumulation of certain acids (excess acid):

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a) Accumulation of lactic acid (lactic acidosis (2 (4, 5, 6, 16: Relationship to AIDS, 18 p.815 f

b) Accumulation of keto acids (ketoacidosis) (2 (18 p.815f) )

c) Enrichment of dicarboxylic acids by acyl-CoA dehydrogenase defect for medium-length chains (2 (10) )

4.) Metabolic disorders that lead to excess bases (metabolic alkalosis) (2 (18, p. 903) )

5.) Wrong diet

{That's why my homeostat contains the substances listed in all claims}

Interestingly, the pH of carcinomas decreased from 7.3 to 6.2 with increasing carcinoma mass (and that hyperglycemia affected carcinoma temperature; similar to how tumor blood flow and oxygen partial pressure Pq are related to temperature).

Explanation:

The supply of blood vessels to a tumor plays an important role in the adjustment of the acid-base balance in tumors. The fact that the pH value is higher in smaller tumors is probably related to a stronger perfusion and the associated faster removal of lactic acid (2 (19), p. 434).

Hyperglycemia also increases the extracellular tumor pH

When glucose is loaded, the decrease in tumor pH is preceded by a rapid decrease in tumor temperature. This can only be

by a selective obstruction of tumor blood flow during glycemia (produced with glucose) (possibly as a result of a reduction in pressure in the tumor capillaries caused by osmotic imbalance and glycemic shock, thus contrary to the Hagen-Poissell law). As a result, the outflow of lactic acid from the tumor also decreases, and lactic acid is also produced from glucose in the tumor, which leads to tumor hyperacidity and is desired and intentionally brought about the destruction of tumor tissue.

Hyperthermia alone led to a decrease in tumor pH and tumor blood flow; its effectiveness was increased when combined with hyperglycemia. The combined hyperglycemia-hyperthermia treatments have led to many "successful results" (2 (19 p.435)). In one study, hyperglycemia did not increase the effects of hyperthermia, which was explained by the fact that hyperglycemia did not reduce the pH. The results described above as "successful" refer to the destruction of tissue, namely tumor tissue. At the same time, however, this makes it clear that tissue in which acidosis has built up is to be regarded as poisoned tissue that, loaded with metabolic poisons, is heading for destruction, possibly also through the formation of solid deposits (amyloids, prions). All claims, in particular claim 2, are intended to prevent this.

In addition, the connection between solid deposits (stone formation, lithiasis) and cancer as a result of chronic irritation is reported in the literature (2 (20 b p.374)

The composition of bile follows physico-chemical rules, and diluted bile has a smaller micellar zone than concentrated bile, which makes precipitation of stones more likely; very diluted bile can therefore

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Cause of gallstones and, as a result, gallbladder cancer ;

' The causes for the formation of very diluted bile include, in addition to bacterial overgrowth of the bile vessel branches and cholestasis with liver secretion of diluted bile, the secretion of a hydrocholeretic compound that binds more water per bile salt molecule and thus causes a smaller micellar zone and precipitation.

Bile fats with lower chain length also cause more dilute bile.

I mention this to draw attention to the importance of the micellar zone. The same physical-chemical rules that apply to bile are of course valid for all areas of the organism. And the acid-base situation (pH value) also has an effect on the micellar zone (2 (20 a p. 55)), so that a disturbed acid-base balance will promote the formation of solid deposits in the tissue in general (from a physical-chemical point of view).

Therefore, my homeostat also contains natural additives which are intended to have a positive effect on all micellar zones of the body in the sense of a regulated "micellar homeostasis"; and this can certainly be achieved with a suitable food supplement (2 (20 b p.374) ), for example through the controlled addition of natural detergents (2 (20a p.49) ) {creating protein-decorated micellar structures}

Description of claim 3:

A free radical is a molecule, atom or group of atoms with an unpaired electron in its outermost orbital, which causes its extreme reactivity . Claim 3 is about preventing the formation of free radicals or, better and more precisely, about the "right" balance between radical and non-radical biological species, i.e. a radical-non-radical homeostasis, i.e. a metabolic-dynamic regulatory balance between radicals and non-radicals, because radicals are not only harmful, they are also needed in the organism, for example to kill pathogens (viruses, bacteria). (In the broadest sense, radical homeostasis is even part of the vital redox homeostasis, because radicals represent transition species between oxidized and reduced species, see in particular the semiquinone radical in claim 5)

The production of free radicals in small amounts is completely normal and healthy in cellular processes, even essential for life (4 (12 p. 1183)). Such healthy radical-generating processes exist in the mitochondrial electron transport system, in reactions catalyzed by prostaglandin hydroperoxidase, and in the autoxidation of small molecules such as catecholamines, as well as in the mitochondrial P-450 reductase system (4 (12, p. 1183)·). Free radicals can play a healthy physiological role, such as in the modulation of certain membrane receptors (4 (12. p. 1183) ) {see also Neural and Receptor Homeostatics, claim 10} including NMDA receptor function.

However, an unauthorized excess of radicals not only destroys pathogens, but also the entire

human organism, leading to all the various "radical diseases" known to the scientific community, from chronic inflammation, rheumatism, cancer to Alzheimer's.

Free radical species of potential danger in cerebral ischemia/injury include superoxide anion radical 0~2 ^and -hydroxyl radical -0-H (4 (12, p. 1183)). During traumatic and hypoxic injuries, free radicals are formed in excess because there is too little oxygen available to take up all the free electrons that are released along the mitochondrial electron transport chain, which leads to their attachment to other components of the chain, thus to their reduction (instead of the (lack of) oxygen) such as flavin adenine dinucleotide (FAD) and ubiquinone (Q). These can then autoxidize and form unphysiological free radical species.

Free radicals can also form during reperfusion as byproducts of the arachidonic acid reactions to prostaglandins and leukotrienes (4 (12) ) {see oxygen paradox, claim 2}.

Arachidonic acid is particularly enriched during ischemic conditions because it is released from membrane phospholipids during this time; this release is believed to be triggered at least in part by NMDA receptor activation and subsequent activation of Ca^ ⁺ -dependent phosphorase A2 (see claim 4).

The substances listed under claim 3 are the "classic radical scavengers" which - as confirmed by the latest, most modern research methods - prevent the severe deficiency regulation of radicals. Wheat, corn and barley bran contain ferulic acid; Ferulic acid has antioxidant properties and is involved

on the nitrite scavenger effect of wheat bran. It should be particularly emphasized at this point that even proteins help regulate radical homeostasis and thus also llthe correct protein nutrition (3 (8) ), (see claim 8).

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Description of claim 4

I.Review

All mammalian cells use Ca ²⁺ as signals to regulate innumerable life processes such as control of cell growth and differentiation (4 (12, p.1177): possible relationship between Ca ²⁺ homeostasis and cancer development!), maintenance of cytoskeletal integrity, membrane excitability, exocytosis and synaptic activity.

Because of the pilot role of Ca ²⁺ ions as regulators of normal neuronal functions {see Neural and receptor homeostasis, claim 10} , neurons have evolved homeostatic mechanisms to keep both the intracellular arrangement of Ca ²⁺ ions and their concentration in the free cytoplasm well under control (4 (12, pp.1177,1178 ) ).

These mechanisms consist of complex interactions between four general categories of events:

1.) Inflow of Ca ²⁺ , 2.) Ca ²⁺ buffering (see also requirement and intracellular Ca ²⁺ buffers), 3.) internal Ca ²⁺ storage and 4.) outflow of Ca ²⁺ .

A fifth process, internal Ca ²⁺ diffusion, links the four events mentioned above and is also essential for Ca ²⁺ homeostasis.

Together, these mechanisms maintain the intracellular Ca ²⁺ concentration (Ca ²⁺ Ji ^au+ - extremely low levels (~ nmol/L or 100,000 times lower than the extracellular Ca- ² " ¹ " concentration) so that relatively small or localized increases in (Ca ²⁺ Ji can be used ^{by the} cell as signals to trigger a physiological effect such as the activation of an enzyme or an ion channel.

The fine-tuning between these five processes allows independent regulation between many types of Ca ^{2 +} dependent processes within the same cell.

Maintaining this balance is the goal of all clinically relevant strategies to reduce Ca ^{2 +} toxicities.

Link between intracellular Ca ²⁺ homeostasis (4 (12, p.1176) ) and neuronal vulnerability:

Anoxia and ischemia of the white matter of the spinal cord (as a consequence of injury) leads to Ca ²⁺ accumulation, also observed in cerebral ischemia and epileptic injury (4 (12) ). Abnormal ingress of Ca ²⁺ causes damage to the nervous system (4 (12, p.1177) ), and the calcium hypothesis claims that neuronal Ca ²⁺ overload leads to nerve degeneration. Poorly regulated Ca ²⁺ ion concentrations can therefore exert neurotoxic effects (4 (12, p.1177) ).

Ca ²⁺ overloads cause overexcitation of Ca-dependent cellular processes or trigger certain cascades (4 (12, p. 1177) ). Such causal mechanisms of neurotoxicity as a result of the effects of Ca ^{2+ ion overload} 9 are, for example, the overexcitation of enzymes such as phosphogenases, plasmalogenases, calpains and other proteases, protein kinases, guanylate cyclases, nitric oxide (NO) synthetases, calcineurins and endonucleases (4 (12, p. 1177) ).

Excessive stimulation of this Ca ²⁺ -dependent enzyme system leads to an overproduction of toxic reaction products such as free radicals (see also claim 3), lethal changes in the cytoskeletal organization (see above) or activation of genetic signals that lead to cell death.

This can be counteracted at the cellular and molecular levels with Ca ²⁺ channel blockers, radical scavengers (see claim 3), substances that stabilize cell membranes, protease inhibitors (kalpain inhibition) and other blockers of certain membrane receptors such as opiate antagonists and glutamate receptor blockers.
(4 (12, p.1177) ) .

More information on the five event categories for maintaining Ca ²⁺ homeostasis (see above):

Ions gain access to the cell interior via ion channels. These are specific pores in cell membranes, physiologically classified by their specific selectivities for certain ion types (Ca ²⁺ , K ⁺ , Na ⁺ or Cl~) as well as by their shut-off mechanisms.

Some ion channels are sensitive to electrical membrane voltage (channels whose opening or closing is voltage-dependent) and change their configuration between a number of open and closed states, depending on whether the cell membrane is depolarized or repolarized.

Ca ²⁺ buffering:

95%-99% of the Ca ²⁺ ions entering the cell interior under physiological conditions are buffered by cytoplasmic proteins such as calmodulin, calbindin and parvalbumin (4 (12, p.1179)). They possibly act to keep the [Ca ²⁺ ]^ levels high in locally limited areas in order to quickly dissipate the Ca ²⁺ gradients and thereby limit the activation process in a controlled manner;

Ca ²⁺ buffers are also able to increase the diffusion rate of Ca ²⁺ ions within the cell and thus serve as Ca ²⁺ transporters from the site of entry to the site of action. These effects are very precisely balanced and depend on the distribution, type and concentration of the Ca ²⁺ buffers. There is a large variety of different Ca ²⁺ binding proteins in different neurons. These Ca ²⁺ buffers become maximally effective when neurons are challenged with high Ca ²⁺ loads. This is considered to be an indication that Ca ²⁺ buffers protect neurons against Ca ²⁺ neurotoxicity -

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Some authors report a decrease in excitotoxic vulnerability in neurons containing high levels of calcium-binding proteins (4 (12; references 153, 221), others report the opposite (4 (12; references 71, 291) 297 06 643.9

Cells with high concentrations of endogenous Ca ²⁺ buffers show lower Ca ²⁺ entry through the Ca ²⁺ channels and are better able to reduce transient Ca ²⁺ concentration increases induced by depolarization (4 (12; references 33,36) )

However, it is unclear whether such findings also alleviate glutamate-evoked Ca ²⁺ entry into neurons and therefore the resulting neurotoxic process.

Ca ²⁺ storage:

However, the Ca ²⁺ -buffering capacity of cytosolic Ca ²⁺ -binding proteins is also limited.

Therefore, neurons also have mechanisms for allocating (for storage) Ca ²⁺ to certain organelles. These include the endoplasmic reticulum, mitochondria (- however, the Ca ²⁺ stores in the mitochondria are exhaustible - , ■ ·

and excessive Ca ²⁺ sequestration in mitochondria can render them permanently inactive - ) and synaptic vesicles.' This sequestration occurs with the participation of active and" passive Ca ²⁺ transport mechanisms similar to those in the plasma membrane.

However, the storage system works slower.

Disturbances of Ga - ² Ji sequestration are involved in a

A variety of neurological disorders from cerebral ischemia to

towards mitochondrial diseases (4 (12,, p. 1180) ) .

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All cells must expend metabolic energy to release Ca ² -^.

Neurons have two such energetic mechanisms:

ATP-driven pumps (with Ca ²⁺ -ATPases) and a Na ⁺ /Ca ²⁺ exchange transport mechanism (4 (12, references 16, 31, 141, 163, 168, 253) ) Ca ²⁺ -ATPases in the plasma membrane are modulated by Kaimodulin, a series of fatty acid and protein kinases (A and C)

The energy provided by 1 ATP molecule is required to pump 1 Ca ²⁺ ion out of a cell or to sequester 2 Ca ²⁺ ions within a cell (using calmodulin-independent Ca ²⁺ ATPases (4 (12, S,1180) ).

All Ca ^ ⁺ pumping mechanisms depend on the availability of ATP. This explains (4 (12, p. 1180)) why cerebral ischemia or injury (lack of energy from ATP) is associated with Ca2 ⁺ overload of brain cells; the premature depletion of cellular energy stores (their premature emptying) results in deficient Ca2 ⁺ ejection and sequestration. Thus, the influx of Ca2 ⁺ can easily overwhelm the cytoplasmic ^{Ca2+ buffering} mechanism, leading to an uncontrolled increase in the concentration of unbound intracellular Ca2 ⁺ ions, which are then free to activate numerous secondary Ca2 ⁺ -dependent cascades that ultimately result in cell death.

It is therefore important to ensure that the Ca - ² Jt -PUf f er proteins, the membranes and the cellular energy stores can be maintained as functional as possible with the help of ATP .

MY HOMEOSTAT IS DESIGNED TO ACHIEVE PRECISELY THIS PURPOSE.

Ca ²⁺ -chelating agents reduce Ca ²⁺ excitotoxicity. They are effective against neurotoxicity and cerebral ischemia (4 (12, p. 1180)).

Mg ²⁺ (as Ca ²⁺ antagonists) reduce hypoxic and anoxic cell death (4 (12, p. 1181) ).

Glutamate-evoked [Ca ²⁺ ]i increases through NMDA receptor channels are much more neurotoxic than equivalent [Ca ²⁺ ] loads evoked by non-NMDA receptors or voltage-gated Ca ²⁺ channels (4 (12) Reference 272). Other (4 (12, p. 1183) ) phenomena generating Ca ²⁺ excess are formation of free radicals which, also when they occur in excess {coupled to or feedback from the arachidonic acid cascade (4 (12, pp. 1183, 1184) ) }, e.g. B. stimulate the Ca ²⁺ -dependent phospholipase A2 or other Ca ²⁺ -dependent lipases and phospholipases triggered by ischemia and contribute to the formation of free fatty acids. NO can also act as a radical and influence the intracellular Ca ²⁺ pool in neurons and neighboring cells through a cyclic guanosine monophosphate kinase (GMK)-mediated mechanism.

The production of :N0 in small amounts, like that of all other radicals, is physiologically normal and necessary for health. Its production is monitored by NO synthetase. This too is regulated by the kaimodulin (4 (12, p. 1184). NO, which is not particularly toxic, reacts with superoxide to form the toxic peroxynitri^ (ONOO"), which directly attacks sulfhydryl groups, lipids, DNA and proteins (4 (12), reference 133).

The extent of this reaction can be moderated by SOD competitively with superoxide radicals.

However, ONOO" can also generate toxic hydroxyl radicals and reacts with certain metals to form the highly toxic nitronium ion (NO ₂ ⁺ ).

These processes establish a proper NO homeostasis within the Ca2 ⁺ homeostasis ("homeostasis homeostasis": this applies generally within my homeostat).

The presumed physiological purpose of these processes is to maintain the dynamic control of the neuronal membrane, the cytoskeleton and other vital cellular structures

Thus, NO production has a homeostatic role and can therefore be either protective or toxic (just like Ca ^{2 +} release) depending on a number of associated modulatory factors (4 (12, references 14,

Tissues with high levels of SOD are relatively resistant to the toxicity of NO and excitatory amino acids (e.g.

Glutamic acid). Genetic overexpression of SOD resulted in resistance to cold- and ischemia-induced brain injury (4 (12, references 32, 296) ) in mice.

Polyethylene glycol-conjugated SOD has a similar effect in humans for the safe treatment of traumatic head injury (4 (12, references 164, 165) ).

CA ²⁺ -NO- HOMEOSTASIS IS PARTICULARLY SUPPORTED BY CLAIMS 3, 5, 6, 15 (but also by all other claims).

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Description of claim 5:

This claim mainly contains plants with active ingredients against complex I - IV anomalies (weaknesses, failures, other metabolic disorders); my homeostat contains considerably more mitochondrial active ingredients from the area of 1,4-benzo- and 1,4-naphthoquinones than just coenzyme Qiq, so that the damaged respiratory chains are offered considerably more repair components. This also includes certain naturally occurring succinic acid esters, which are intermediates of the natural Krebs cycle and which catabolically regulate the ATP (synthesis-degradation) homeostasis (13 (2, p. 274)).

The clinical manifestations of the health damage and impairments caused by respiratory chain defects are described in great detail and in large numbers in the specialist literature.

With regard to all of these manifestations, my homeoste is intended to have a preventive, regulating and alleviating effect.

The main aim of claim 5 is to increase ATP production taking into account its homeostatic norm. For this purpose, various other homeostases are embedded in the redox homeostasis of claim 5, such as the electron-proton homeostasis and thus the acid-base homeostasis (5 (3) ), the glutathione homeostasis, certain radical homeostases of the respiratory chain as well as the insulin and mitochondrial protein production homeostases.

From this alone it can be concluded that mitochondrial homeostases represent extraordinarily sensitive equilibria and are particularly in need of protection.

MY HOMEOSTAT IS DELIBERATELY DESIGNED SO THAT IT CAN SUPPORT THESE MITOCHONDRIAL REDOX HOMEOSTASES FROM ALL SIDES.

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Description.· Regarding claim 6: immune response homeostasis

The metabolism of the immune reactions is stimulated or triggered (induced) in my homeostat by immune stimulants (specific and non-specific (6 (1))) released by immune-regulating T helper cells (12(6,8)), B cells (12(7)), macrophages, namely through targeted stimulation of humoral and/or cellular defense mechanisms, whereby all humoral and cellular epithelial (endothelium) associated immune systems (throat-associated (6(1, p. 257)), gut-associated, skin-associated immune systems) are addressed equally, since my homeostat is used orally and loaded with fiber with a long residence time in the intestine and delayed release of the active ingredients due to the fiber content and the particle size distribution. The nonspecific inducer effects (6 (1, p. 257)) include increased recruitment, increased proliferation and activation of defense cells (NK cells, T lymphocytes, granulocytes, macrophages) as well as increased release of immune mediators (monokines and lymphokines, e.g. interleukins, interferons, colony stimulating factor (CSF), tumor necrosis factor (TNF) prostaglandins, lysosomal enzymes, oxygen radicals), increased complement activity.

When the homeostat ingredients are applied to the skin (for example in the form of frequently repeated homeostat baths), immediate immunological measures (before the development of specific immunity) can be achieved by stimulating the T-lymphocytes, histiocytes, Langerhans cells and keratinocytes of the epidermis found in the upper and deeper layers of the skin (however, without leaving behind an immune memory function, hence the frequent repetition of the cutaneous and subcutaneous bath applications) (6 (1, p. 257) ). ■-■■■'.

According to claim 6, my homeostat is intended to help normalize all immune regulations through its homeostatic effect on the immune-relevant systems of the organism.

For example, in a group of patients with active inflammatory myopathies (polymyositis or dermatomyositis), it was measured that the ratio of circulating suppressor to cytotoxic T cells deviated from the norm (6 (5) ), was too small, while the ratio of helper to inducer T cells was found to be too large compared to the ratio of suppressor to cytotoxic T cells. In other words, there were too few suppressor cells present.

A disease-causing disturbance of immune homeostasis in inflammatory myopathies can be traced back to the combined effects of (over)activated T lymphocytes, macrophages and B cells, with the first two playing the main role (6 (6)). The prerequisite for immune homeostasis is therefore activation regulation in defense cells, i.e. activation promoters and activation inhibitors are equally necessary to maintain immune balance regulation. As long as the specific details of the connections are not clarified, only as many homeostasis offers as possible can be used. THIS IS EXACTLY WHAT MY HOMEOSTAT IS SUPPOSED TO DO.

When activated, T cells express a molecule {Fas (Apo-1, CD 95)} (6 (9, 10) ) on their surface, which (along with tyrosine protein kinases, like B cells (6 (9, 10) ) maintains self-tolerance (6 (3) ). This molecule can also cause apoptosis of transformed cells (activation-induced cell death). Antagonists of this molecule are able to block this cell death (6 (3, p. 570) ). ^Chronically activated human T cells express large amounts of such surface molecules. Incidentally, FasL can eliminate CD ⁴⁺ cells (6 (3, p. 572) ),

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What is interesting in connection with the treatment of HIV My homeostat is intended to promote the autoregulation of this surface molecule (Fas or FasL) through its balanced immune-relevant composition. .

Glutamine and glucose are present as the main energy source for thymocytes (6 ( 8) ).

The ingredients of my claim 6 - in particular ginseng root (6 (4) ), garlic (6 (7) ) and vitamin A (6 '

(11) ) are suitable to counteract immune imbalance disorders.

Claim 6: Immune response homeostasis

B. ) TNF (tumor necrosis factor) homeostasis

In conjunction with an induction of TNFa in macrophages located in the tumor area ( 12 (10) ), the regression of established epidermoid carcinomas was demonstrated. Tumor regression was also demonstrated after a local injection of a-tocopherol, canthaxanthin and a Spirulina-Dunaliella algae extract.

Regression of epidermoid carcinomas was also possible after local injection or local application of ß-carotene (.12 (3) )".

ALL THESE TNF-INDICATING SUBSTANCES ARE CONTAINED IN MY HOEOSTAT.

These lead to an immune enhancement . TNF kills tumor cells. This cytokine TNF can have an anti-tumor effect (12 (Ib) ), but can also have a destructive effect on healthy tissue (12 (Ib) ), because bacterial lipopolysaccharide (LPS) causes tissue damage, which is caused by LPS-induced TNF, e.g. bacterial endotoxins are not toxic in themselves (12 (lc, p. 379) ), but they provoke the development of hostile factors in the body's own cells of hematopoietic origin, which can lead to shock and cell death. (As early as the turn of the century, cancer cells could be killed by bacterial infection and cancer could thus be cured.) Today, immunotoxins are chemically "tailored" as antibodies against substances (antigens) that trigger immune responses with defined target groups against cancer (e.g. anti-T65 immunotoxin, anti-p97 immunotoxin, Ig M anti-Zhy 1.2 immunotoxin, tailored from certain

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Heptaphors and toxophores of the natural product ricin; ricin itself also has cytotoxicity against cancer; these immunotoxins inhibit the synthesis of RNA and proteins and their inhibition kinetics are the subject of intensive research) (12 (9) .).

However, with my homeostat, TNF homeostasis is to be achieved through naturally occurring mechanisms and natural modulating factors:

LPS toxicity can be enhanced by certain sensitizing agents and, conversely, a controlled sublethal dose of LPS can sensitize its toxic effect ( 12 (16, references 4-7, 8) ). The lethal effect of TNF is also significantly enhanced by sensitizing agents, particularly those that inhibit the synthesis of RNA and proteins (12 (Ib, references 9-12) ) (, whereas the killing effect of TNF is reduced when cells are pretreated with TNF.) Thus, RNA synthesis in cancer cells is presumably stopped by TNF, because (12 (ld, p. 5317) ) in addition to its effect against tumors and malignant cells, TNF influences the mitogenesis, differentiation and immune regulation of different cell types; TNF binds to its target cells through high affinity surface receptors (12 (lc, p. 5317) ). There is evidently a homeostatic regulation between RNA and protein inhibitors, LPS and its sensitizers, Act D and Ga 1 N and TNF (the cytokines Act D and Ga IN make cells vulnerable to the cytokine 11-1 (interleukin 1), but also to TNF).

The cytotoxic activity of TNF is triggered by early damage to mitochondrial functions (122 (ld, p.5317) ). Treatment with TNF led to degeneration of mitochondrial ultrastructure and to an inhibition of mitochondria to oxidize succinate and NADH-linked substrates (12 (1, p. 5317) ). The inhibition of electron transport of the respiratory chain was (TNF-) dose-dependent (i.e. with

With increasing concentration of TNF, a maximum rate of inhibition is reached (12 (9) )) clearly visible 60 min after the start of TNF treatment and thus preceded the onset of cell death by 3 to 6 h (12 (ld, p. 5317) ). Complex IV activity, on the other hand, was only slightly impaired. Thus, as part of an immune response homeostasis, the respiratory chain complexes I, �Pgr; and �Igr;�Pgr; Thus , mitochondrial homeostasis (see claim 5), proliferation homeostasis (regulation of cell proliferation (12 (2-4) }, luteinizing hormone-releasing hormone agonists (12 (5) ), glutathione (12 (4) ), antioxidants (see this claim, part A) (in particular also iron (&Pgr;) chelators (see claim 3); e.g. supplementation of the diet with ß-carotene modulates TNF production by human monocytes (12 (1) ) ), protease inhibitors, lysosomal enzymes and glucocorticoids contribute to the entire TNF homeostasis in a natural way.

FROM THIS IT FOLLOWS THAT MY OVERALL HOMEOSTASIS REQUIREMENTS ARE USEFUL, SUFFICIENT AND NECESSARY TO MAINTAIN TNF (CACHECTIN) HOMEOSTASIS AND TO AVOID OR RELIEVE CACHEXIA (pathogenic endotoxin-induced shock).

Infectious and neoplastic diseases have a metabolic trigger, in that invasive diseases interrupt normal homeostatic regulatory mechanisms (12 (Ic) ) both locally and systemically, e.g. gram-negative infusions (12 (lc, p. 379) ) lead to severe metabolic acidosis (see claim 2) and to changes in plasma glucose concentration (see glucose homeostasis, claim 8, part B), - both clinically visible as hypotension, intravascular coagulation and tissue injury - as well as to disturbances in nitrogen homeostasis.

However, the invasive agents themselves are not responsible for the homeostasis disturbances listed, but rather endogenous mediators (see above) which

stimulate the body to produce hostile factors.

IT IS PRECISELY SUCH DERAILMENTS THAT I TRY TO PREVENT WITH THE ENTIRE CONTENT OF MY HOMEOSTAT SO THAT A METABOLIC INTERRUPTION OF NORMAL HOMEOSTATIC REGULATIONS CAN BE AVOIDED OR AT LEAST GREATLY ALLEVIATED AND THE IMMUNE RESPONSE - TOGETHER WITH TNF HOMEOSTASIS CAN BE MAINTAINED AS WELL AS POSSIBLE.

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Description of claim 7: Permeability barrier homeostasis

The ingredients of claim 7 are intended to regulate all processes homeostatically, which take place in functional epithelia and endothelia, such as electrolyte transport in the intestinal area (7 (2) ), where mast cells take over this regulation by releasing histamine (response mediator of the smooth muscles) and prostaglandins after Ig E or Ig Gj stimulation.

(intestinal secretagogues that act on the intestinal epithelium and are synthesized de novo following immunological stimulation of mast cells) and mediate electrophysiological (ionic) changes in the intestinal epithelium (via physiological messengers), whereupon Cl~ secretion is initiated as a reflex, intracellularly mediated by cyclic adenosine monophosphate (c-AMP). Electrophysiological changes also occur with an incorrect diet (7 (9, Table 4) ), e.g. For example, the basal transepithelial electrical potential of the jejunum is -2.0 mV on a high-protein diet and -1.5 mV on a low-protein diet (7 (9, Table 4) ), so that the protein content of a diet has an immediate and direct effect on the electrochemical functionality and immune capacity of the jejunum (see also 8 (18) ). Proteins (but not amino acids, carbohydrates or fats) also stimulate cholecystokinin production, a visceral hormone that stimulates and regulates both gallbladder and pancreatic secretions and is localized in endocrine cells of the proximal small intestine (intestinum tenue) (8 (4) );

it is a major regulator of pancreatic secretion, which is regulated by a feedback mechanism (8 (4, p. G 247) ). Protein is the main stimulant for the release of this hormone; the peak plasma response to its

orogastric administration occurs after just 5 minutes, somewhat dose-dependent. Of the proteins tested, casein (18%) was a stronger releaser of the hormone than BSA or lactalbumin. SBTI (60.2%), a protein trypsin inhibitor, caused the strongest increase; an amino acid mixture also stimulates. Stimulation occurs only through protein substrates, not through the end products of proteolytic digestion (8 (4, p. G 247)).

Immunologically stimulated (see Ib) mast cells can stimulate Cl" secretion specifically and epithelial physiology in general (7 (2, p. G 261)).

My homeostat is - particularly through claims 7 and 8, but also through all other claims - designed to keep the mast cells as functional as possible. The better the epithelial immune stimulation works, the better the intestinal tissue is protected, e.g. from hydroxyl radicals, which are formed by Fe ²⁺ in the intestine (7 (3, p. 713) ) and can trigger colon cancer, just as oxidative stress - caused by incorrect nutrition, e.g. by protein malnutrition (see above) - can lead to intestinal malfunctions and even cause chromosome damage (7 (9) ). A correct diet composition in this sense with a high protein content and with mineral and vitamin mixes can be found in ( 7 (9, Table 1) ). (This was contrasted with an incorrect nutritional composition with a low protein content.)

SUCH MODERN NUTRITIONAL KNOWLEDGE IS INCORPORATED INTO MY HOMEOSTAT.

Excess Fe ²⁺ that causes colon cancer can be complexed by inositol hexaphosphate, phytic acid, - contained in plant seeds, ζ. β. in linseed - (Fe ^{2 +} -hemostasis built into the redox and permeability barrier homeostasis), which further reduces the likelihood of colon cancer development (in addition to fiber richness, see wheat bran (7 (3) )■) (7 (2;3) ). Garlic (wild garlic) also has anti-cancer effects

&phgr;&phgr; »φ φφ φφ ··· φφ φφ

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Fi-

Methionine homeostasis must also be incorporated into permeability barrier homeostasis, since excessive methionine levels due to excessive methionine content in proteins lead to endothelial injury or dysfunction (7 (5) ) and to preferential storage of metabolic energy as fats (lipids), which can trigger atherosclerosis due to methionine excess; methionine-enriched diets cause both hypercholeserolemia and hypertriglyceridemia, and both are known risk factors for atherosclerosis. Glycine facilitates the utilization of methionine. Fat-soluble residues of triglyceride-rich proteins can be cytotoxic to endothelial cells in culture, and it has been postulated that they are hydrolyzed by lipoprotein lipase near the vascular endothelium, thus exposing endothelial cells directly to increased levels of free fatty acids. Single free fatty acids cause destruction of endothelial barrier function, increase intracellular free calcium, and induce oxidative stress. All of these can be prevented by methionine homeostasis (7 (5, p. 1255) ).

The bioavailability of the isoflavones in soybeans depends on the intestinal microflora (7 (6) ); my homeostat therefore also contains the microflora homeostatically building additives (microflora homeostasis, e.g. CoI i-Acidophilus^ homeostasis).

Likewise, in lung tissue, glutathione homeostasis plays a major role in oxidative stress. It is significantly involved in the oxidant-antioxidant homeostasis of the lung epithelium; its disruption manifests clinically as lung disease, particularly emphysema. The respiratory epithelium is frequently exposed to oxidants such as ozone, smoke and reactive oxygen intermediaries released from neutrophils recruited during respiratory disease. (Inflammatory changes in the respiratory epithelium can also be caused by viral, bacterial or fungal diseases (7(16) )).

Glutathione is a strong nucleophile that intercepts epithelium-destroying electrophiles by reacting with them. It is essential for the lung epithelium, which is particularly exposed to electrophiles.

The lungs cannot maintain healthy life without glutathione homeostasis (7 (a,b) ).

Corneal layer

Injured stratum corneum produces cholesterol and fatty acids (within 1-2 hours; especially palmitic acid) and sphingolipid delayed (7 (8) ); zinc is necessary for fatty acid metabolism (7 (8 c) ). The strata corneum function is also important for the absorption of plant ingredients from full baths (7 (10) ). My homeostat could also be added to the bath water, especially its herbal component (phyto-balneo treatment). For example, (7(1) ) teaches about percutaneous absorption (including benzoic acid, hydrocortisone, inulin and thiourea): it sets in (after 30 min) a stationary flow through the skin, which is strongly molecule-dependent and can be calculated; the mean lag time (until the onset of percutaneous penetration of the above-mentioned molecules) was 11 min. The stratum corneum generates reflex mechanisms and exerts systemic effects after cutaneous absorption (see also Figure 15, Reference 7 (15) ).

There is also an electrical model for the epidermal epithelium (as for the jejunal epithelium, see above) (7 (20) ): it combines the non-linearity and asymmetry of the current-voltage characteristics of the skin, e.g. after stimulation. The electrical breakthrough occurred when the applied electrical energy exceeded a threshold. This was also determined (see also visceral epithelium) with electrolytes (7 (20) ). Above this threshold, the current-voltage

Characteristics of the skin non-linear and asymmetric (and one test subject then felt an unpleasant feeling.) To achieve a well-developed stratum corneum permeability barrier function, the additives palmitic acid, adipic acid, zinc, biotin, hyaluronic acid, phospholipids, reduced glutathione, phytate are used.

• · · * · II ^s **&idigr;&iacgr;&iacgr;

Description of claim 8: Nitrogen, lipid, carbohydrate homeostasis

A. ) ■ ■

This description refers to the establishment (regulation) of the balance between proteins, fats and carbohydrates as well as their regulatory functions.

The energy balance in the body can only be maintained through the correct protein, fat and carbohydrate balances. Individual balances are combined and regulated separately (8 (14, p. 1558)). Achieving the overall balance requires that the net metabolic energy from the metabolic combustion (= oxidation) of each of these groups is equal to the average of all of them together, i.e., for example, proteins, fats and carbohydrates may only be consumed (eaten) in such weight ratios that they provide the same amount of energy during metabolism. Since, for example, fats and carbohydrates have significantly more calories than proteins, significantly smaller amounts of fat must be consumed than protein in order to achieve the healthy energy balance. The same applies to carbohydrates. The weight amounts of the substance group from claim 8 must be such that each group provides 33% of the total number of calories. Then the homeostasis of proteins, fats and carbohydrates is fulfilled (8 (15, p. 1558)). The regulations of the carbohydrate-protein balance are more closely linked to each other than to the regulation of the fat balance.

The regulation of carbohydrate balance has the highest priority because carbohydrate stores (e.g. glycogen) can only cover carbohydrate homeostasis for a few days,
Different carbohydrate types (e.g. sucrose, glucose,

Fructose, complex and simple carbohydrates (see 8 (14, Table 3, p. 1557) have different effects on insulin production and therefore have different glucose tolerance. Insulin is an important determinant of carbohydrate-induced involvement of the sympathetic nervous system. The digestion of different carbohydrates can lead to different post-Prandellian responses (8 (14 p. 1558)); simple and complex carbohydrates give different responses with regard to glucose tolerance, energy metabolism and blood lipid spectrum (8 (14)); for example, there are differences in post-Prandellian thermogenesis with sucrose or fructose, which are more thermogenic than glucose, in both lean and obese individuals. The ß-adrenergic nervous system contributes to fructose-induced thermogenesis (8 (14, p. 1558)). It is documented that the increase in energy production and carbohydrate oxidation is impaired in obesity and type Π diabetes. This is related to possible differences between the various carbohydrate types for the regulation of the overall energy balance and the overall protein-fat-carbohydrate homeostasis: after the digestion of food, there is an increase in resting energy production (increment, thermogenesis), because the conversion into the storage form costs storage energy (mandatory component of the increment). The energy component of the entire thermogenesis that is not used for storage is called the regulatory component of thermogenesis, and this has been attributed to several factors, e.g. increased activity of the sympathetic nervous system, increased recycling of substances, and others (8 (14, p. 1558)).

Excess (i.e. overeaten) carbohydrates, unlike fats, promote their own combustion in the organism (oxidation) by stimulating the cellular uptake and oxidation of glucose:
Carbohydrate and protein stores are thereby

- 18-

regulates that surpluses are metabolized immediately, whereas excess fat intake goes directly into fat storage (8 (14, p. 1558). THIS IS TAKEN INTO ACCOUNT IN THE COMPOSITION OF MY HOMEOSTAT.

Proteins and fats in particular have regulatory functions (8; 4, 5) ):

Thus, only proteins regulate cholecytokinin secretion and thus regulate bile and pancreas (8(4) ). A 'main protein source is soy' (8(13) ), which is also rich in phytic acid (see claim 7).

Fats regulate the LDL plasma level. As we get older, the number of LDL receptors and their activity decreases, leading to a reduction in the LDL fraction that is broken down per unit of time - which causes an increase in LDL levels in the plasma as we age. But even with functioning receptor activity, the rate of breakdown (FCR: Fractional Catabolic Rate) for LDL decreases with increasing LDL levels, or its production rate increases; LDL can therefore be removed from the plasma via receptor-dependent and receptor-independent pathways. This rate of removal is slowed down in old age, so that higher LDL levels, which cause arteriosclerosis, are present in old age. MY HOOEOSTAT BECOMES ALL THE MORE IMPORTANT IN OLD AGE BECAUSE IT REGULATES THE LDL LEVELS "FROM THE OUTSIDE" VIA A DIETARY SUPPLEMENT. With a diet low in cholesterol and triglycerides (cf. Fish proteins and fish fats: the addition of unsaturated fatty acids (eicosapentaenoic, linolenic and docosahexaenoic acids) increases receptor activity for LDL), the ratio of LDL to cholesterol concentration in the plasma remains essentially constant over the entire lifespan (8 (5, p. 560 and references 13-16)). (This changes dramatically with a diet rich in triglycerides and cholesterol.)

79-

Unsaturated fatty acids (fish fats) can regulate the LDL concentration well (8 (5, p. 565) ) and thus prevent arteriosclerosis; this is particularly important in old age, because the weight of the organs important for LDL breakdown, the liver and small intestine, decreases so much that this alone causes the plasma LDL level to increase (8 (5, p. 566) ), which carries the risk of arterial and coronary heart disease (myocardial infarction) (8 (5, p. 559; 11) ). In addition to the unsaturated fatty acids, the oyster mushroom Pleurotus ostreatus (which contains the mitochondrial respiratory chain activating compounds, see also claim 5) also accelerates the LDL plasma clearance and the HDL plasma clearance (8 (9) ).

Magnesium deficiency disease can also produce an increase in serum cholesterol, which can be normalized by an appropriate amount of magnesium in the diet, e.g., corn diet reduces serum cholesterol levels and increases Mg levels (8 (11) ).

There is also an inverse relationship between dietary Mg and the amount of lipid deposited in the heart and aorta. In addition, arteriosclerotic lesions are reduced by magnesium intake (8(11)). Serum calcium is inversely correlated with serum lipid concentration; however, no such correlation was found for Mg despite the beneficial effect of dietary magnesium; but since intracellular magnesium concentration is much higher than extracellular, and the amount of magnesium in serum is therefore not representative (- there may be intracellular Mg deficiency despite certain serum Mg levels-), serum magnesium levels are not sufficiently conclusive. It may well be that higher levels of magnesium in the body can also be explained as being effective against hypertriglyceridemia and hypercholesterolemia (8(10-12)). The main clinical manifestations of hypertriglyceridemia are eruptive xanthomata and acute pancratitis, while the"

go-

Main forms of hypercholesterolemia with premature coronary heart disease. THIS SHOULD BE TREATED FROM THE BEGINNING WITH FOOD (8 (1, p. 26)). MY HOMEOSTAT IS PARTICULARLY SUITABLE FOR THIS according to claim 8.

Specially selected proteins and fats (fish proteins and fats) can jointly prevent the development of cancer (8 (6-8) ). Not only the amount of dietary fat, but also the fatty acid composition are important for the development of cancer in the colon (8 (15, p. 4793) ). Eicosapentaenoic acid (EPA) has an inhibitory effect on this carcinogenesis; it suppresses the excessive production of prostaglandin E2 in colon tumors (8 (15, p. 4793) ): because prostaglandin could be linked to the development of cancer, as it competitively inhibits cyclooxygenase (8 (15, reference 19) ). In a diet with eicosapentaenoic acid, less PgE2 is found in the colon tumor than in a diet with linolenic acid; the latter even promotes the spread of tumors , even more than saturated stearic acid.

The involvement of prostaglandins in cancer may be a distortion of cellular and humoral immune response; PGE2 has been shown to inhibit lymphocyte proliferation, lymphokine production such as interleukin 2, antibody production by B lymphocytes, natural killer activity and macrophage-mediated cytotoxicity against cancer cells. FISH OIL ADMINISTRATION RESULTED IN BETTER CELL-MEDIATED IMMUNE RESPONSE THAN SUNFLOWER OIL. In addition, eicosapentaenoic acid reduces the concentration of secondary bile acids in the colon, which are themselves strong tumor promoters.

TO PREVENT COLON CANCER, THE FOOD SHOULD BE AS RICH AS POSSIBLE IN FISH FATS, BUT AS LOW AS POSSIBLE IN SATURATED FATS (BACON, BEEF FAT, PORK FAT) AND AS LOW AS POSSIBLE IN LINOLENIC ACID (SUNFLOWER OIL). A sample diet with eicosapentaenoic acid is presented in (8 (15, Table 1) ).

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Description of claim 9: Hormone homeostasis
Hormonal imbalances can be

a) relatively elevated estrogen levels with relatively low progesterone levels (pre-menstrual syndrome). This manifests itself in psychological and physical symptoms (a few days before the onset of menstruation): anxiety, irritability, mood swings, insomnia, headaches, feeling of tension in the breasts, bloated abdomen and edema in the legs (9 (1, p. 307) );

b) reduced estrogen and gestagen production and simultaneous increased secretion of gonadotropic hormones (climacteric syndrome) with a significantly greater increase in follicle-stimulating hormone (FSH) compared to luteinizing hormone (LH), so that the relationship between these two gonadotropin hormones is reversed. In addition, extraglandular estrone synthesis (in the adrenal cortex and the ovary) increases.

This manifests itself in a syndrome triad, ie in vegetative-endocrine complaints (hot flushes, sweating, dizziness, palpitations, stabbing pains in the heart region, paraesthesia (tingling, pins and needles), shortness of breath, globus hystericus, labile hypertension, sleep disorders, etc.), metabolic functional complaints (osteoporosis , increased cholesterol and lipid levels in the serum, circulatory disorders, hypertension, weight gain, myalgia, arthrosis, skin atrophy, craurosis vulvae, urinary incontinence, bleeding abnormalities), as well as in endocrine psychological complaints (depression, emotional instability, lack of drive, fear of life, lack of concentration, sleep disorders, etc.).

Such hormonal imbalances can be counteracted by substitution with estrogen itself or with estrogen-hormone mimetic plants, which are contained in my homeostat; for example, in ancient times, chasteberry was used as a remedy for diseases of the uterus and in the Middle Ages as a galactagogue, emmenagogue and aphrodisiac (9 (1, p. 309, p. 311, Fig. 12.4) ). The black cohosh rhizome (Cimcifugae racemosae rhizoma (radix), Cimcifuga (Actea) racemosa) was used by Indians against the consequences of snake bites and for obstetrics, and in the 19th century against febrile rheumatism (9, p. 311, Fig. 12.5).

-S3-

Description of claim 10: Neuronal and receptor homeostasis

There are numerous publications on the regulatory interaction of different receptors:

For example, cholinergic activity is altered in Alzheimer’s disease (10 (7) ).

The predominant receptor class in the cholinergic receptor system is its muscarinic subsystem, so that muscarinic antagonists could be mimetics for the cognitive deficits in Alzheimer's disease. Alzheimer's disease is characterized by specific deficits in brain blood flow and brain metabolism both globally and in Alzheimer's-specific areas of the temporoparietal cortex (10 (7, p. 313)). Blocking the muscarinic subsystem does produce cognitive deficits, but cannot reproduce the regional blood flow changes characteristic of Alzheimer's disease, which is possible by blocking the nicotinic-cholinergic subsystem (nicotinic receptors). In combined muscarinic and nicotinic blockades in healthy subjects, strong effects (cognitive deficits) were only found with the nicotinic blockade. In the combined blockade, the deterioration in blood circulation could also be demonstrated.

To counteract Alzheimer's disease, it is therefore important to ensure that the activities of the nicotinic receptors are maintained and that their number does not inevitably decrease sharply (the number of cholinergic receptors is a logarithmic function of age; there is also an age-related increase in the tone of the sympathetic nervous system (10 (3), increase in plasma (basal-supine) norepinephrine levels).
This can be a homeostatically correct diet (see

·

Claim 8), a good regulation of homeostatic and adaptive response to (metabolic) stress (IO (6, p. 191; references "Sapolski 1992"), a good ongoing reflexive demand on the nervous system through remote stimuli, e.g. through essential oils (10 (4 p. 126f) as well as new learning that extends into old age (10 (6, p. 190)).

Malnutrition in early life, for example, impairs alpha-2 adrenoreceptor regulation of noradrenaline release in the cerebral cortex (10 (1) ). A feedback mechanism at regulatory axon terminals is interrupted. Furthermore, ß-adrenergic deviations have been demonstrated in breast cancer cells (10 (1) ), ß-adrenoreceptors are also involved in the growth and differentiation of cancer cells; a connection between their stimulation and tumor growth is assumed. ß-adrenoreceptor homeostasis with its agonists and antagonists also controls lactogenesis in the mammary gland. These agonists and antagonists are bound to cell membranes as ligands with different dissociation constants (binding strengths). Their release from there must be well regulated homeostatically. This also includes the requirement for good cell membrane function, which is part of the function of this homeostasis. In human breast cancer, a correlation was found between ß-adrenoreceptor stimulation (which leads to increased cAMP production) and estrogen and progesterone receptor functions, which suggests ß-adrenergic control of hormone-sensitive breast cancer.

MY HOMEOSTAT IS ALSO INTENDED TO HELP WITH THIS REGULATION ON THE BASIS OF ITS MULTIPLI QUOTATION.

Furthermore, hepatic denervation has an influence on long-term NaCl homeostasis (10 (2) ) and on arterial blood pressure, so that the liver nerves play a decisive role.

Can influence long-term blood pressure regulation in a high-salt diet as well as excretion by the kidneys in response to oral NaCl intake, and thus the liver nerves also influence long-term control of the amount of body fluid. But the liver nerves could also control NaCl absorption and/or fecal NaCl excretion. For example, jejunal NaCl absorption was completely eliminated by liver denervation.

Furthermore, the liver nerves could also control the appetite for salt.

But the liver nerves contain not only the afferent fibers of the hepatic NaCl receptor, but also the afferent fibers of the hepatic osmoreceptor, baroreceptor, glucose receptor, etc. as well as many efferent fibers. The liver nerve only intervenes in a homeostatic regulatory manner when there is a high NaCl load.

However, this shows what consequences an unbalanced liver can have. MY HOMEOSTAT OFFERS A GOOD CHANCE FOR MAINTAINING HEALTHY LIVER. (See also herbal liver protection group, claim 14)

Only in the human brain is there still a "temporal homeostasis" of phylogenetically and ontogenetically advanced neurons, acetylcholinesterase-rich pyramidal neurons in the neocortex and hippocampus, which are not present at birth but only establish themselves during adolescence, increase during adulthood and are probably also present in old age, but are no longer found during Alzheimer's disease (10 (8) ); it is likely that their development represents an increase in acetylcholinesterase expression in pre-existing pyramidal neurons. How this expression is initially kept under control, which triggers the changes at the different life cycle stages, I call the evolutionary temporal neuron homeostasis of the mental

the mental development of humans, so that this also depends on a homeostatic substrate regulation .

Description of claim 11: Skeletal homeostasis

CALCITONIN CONTAINED IN SALMON has been shown to be effective against postmenopausal bone loss (11 (3a, 3c, 4) ). It is also effective against hypercalcemia and Paget's disease. Improvement in bone and joint pain has been reported; serum calcium levels have also decreased (11 (3b) ). . '

Many efforts have been made to increase its bioavailability (intranasal, intramuscular); however, freeze-dried stockfish will be added to my homeostat to ensure a constant supply of calcitonin (and vitamin D) to the organism.
Vitamin D metabolites also have an effect against osteoporosis.

An increase in skeletal muscle growth can be induced by chromium (as a trace element) (13 (3) ).

Xylitol supplementation to the diet, combined with calcium salts, significantly improves the bone bioavailability of calcium salts (the best effect was calcium carbonate and lactate, combined with xylitol; calcium citrate is also possible) (11 (8)).

Regarding the plants effective against menopausal osteoporosis and the insulinotropic plants , see the descriptions of claims 8 and 9.

Description

Claim 12: Trace element homeostasis Multiple trace element (trace mineral) preparations from

Fe, Zn, Mn, Cu, Mo, V, Ni, B, F, Co, combined with glycerin, EDTA, glycine, L-(+)-tartaric acid, succinic acid, L-(+)-ascorbic acid (15 (8, p. 246) ), This mixture showed an effect on the hepatic-microsomal defense system for lipid peroxides (xenobiotic transformation enzyme system: polysubstrate monooxygenase system, consisting of cytochrome P-450, cytochrome b5, cytochrome c oxidoreductase, aniline p-hydroxylase, p-nitrophenol hydroxylase, aminopyrine N-demethylase, p-nitroanisole O-demethylase) . The amount or activity of these enzyme system components decreased after administration of the multicomponent trace element preparation, so less lipid peroxide was formed. ' ,

According to another study, a multicomponent trace element preparation increased the activity and stem cell transformation of spleen lymphocytes (measured by T cell1-specific mitogen induction). In human peripheral blood lymphocytes, this specifically promoted the activity and stem cell transformation of T lymphocytes, and the trace element mixture had little effect on B lymphocytes. This trace element treatment also resulted in an increased expression of surface receptors (typical of a cytotoxic subpopulation), increased the activity and exocytosis of serine proteases that occur in the large electrodense granules of cytotoxic cells. From all this, it can be concluded that trace elements play a pioneering role in immune functions and that homeostatically regulating supplementation with selected trace elements can modulate the activation, proliferation and cytotoxic activity of certain lymphocyte subsets (15 (8))

A multiple trace element preparation can also be advantageously combined with a multiple antioxidant vitamin preparation (15 (8, p. 244)): Zn, Se, ß-carotene, vitamin E, ascorbic acid; after three months, serum zinc and selenium were significantly increased. (After 0, 3 and 6 months, the following were also measured: plasma ascorbic acid, plasma alpha-tocopherol, plasma beta-carotene, plasma and erythrocyte glutathione peroxidase, erythrocyte superoxide dismutase, serum thiobarbituric acid and reactants as well as total blood glutathione and diglutathione.) It was also shown that a combination of ß-carotene, Se and vitamin C inhibits pancreatic carcinogenesis (15(6)).

Selenium (substituted with 0.1 mg daily), enriched in garlic and broccoli, is effective against heavy metal poisoning (p. 226), it acts in humans as part of the active sites of type I iodothyronine 5'-deiodinase and glutathione peroxidases (GPx), which play a major role in the detoxification of both endogenous free radicals and free radical species generated by exogenous compounds. In addition, selenite and selenate, after their metabolism, can detoxify many carcinogenic and toxic substances by reacting with them (e.g. Hg, Cd), with which selenide is formed, which is fixed by proteins to form complexes, which are then excreted by the reticuloendothelial system. The following mechanisms have been described with regard to anti-cancer effects: antioxidant effect (via GPx), a role in growth factor activation-inactivation systems, an effect on cell growth through protein synthesis inhibitors, DNA protection by preventing its methylation, enhanced DNA repair, modification of carcinogen metabolism, detoxification of both heavy metals and xenobiotics, increased production of interferon and a positive effect on NK cells. Selenium has been shown to significantly reduce tumors .

- 9o -

Chronic renal dysfunction (with the two complications of uremic myocardiopathy and increased cancer incidence) affects selenium status (15 (Ha) ). A major form of selenium in the human diet is seleno-methionine (15 (Hb) ), and the chemical form of selenium intake has an influence on the distribution of selenium in the blood: selenite leads to glutathione peroxidase-associated selenium in the red blood cells, while in selenium-rich wheat or seleno-methionine the majority of selenium was in hemoglobin. Selenium can substitute for sulfur in amino acids (see 15 (11, Table 4) ). The trace element content of foods is reported (15 (Hd) ).

Zn/Cu: . ■ ■ ■

Zinc and copper are strongly involved in the regulation of inflammatory processes (225). Their simple salts, their heterogeneous organic complexes as well as biological molecules (Cu-Zn-SOD, ceruloplasmin) have anti-inflammatory and antiarthritic properties. Zinc L-cysteate has the best zinc bioavailability (232). Also suitable for dermatology. Several clinical features of zinc deficiency resemble those of a deficiency of essential fatty acids (8 (8) .). Susceptibility to infectious diseases in the case of a low plasma zinc content can be counteracted by zinc supplementation (15 (9a) ). In general, the stimulation of the immune system during an infection triggers a series of metabolic changes including the redistribution of trace elements such as iron, zinc and copper in several body compartments. This change, which is preceded by the hepatic synthesis of specific ligands such as ferritin, metallothionein and ceruloplasmin, is closely correlated with the defense mechanism against invading pathogens. For example, zinc accumulates in the liver and

other organs, while it decreases in plasma. This improves the phagocytic activity of macrophages and polymorphonuclear cells. On the other hand, a chronic zinc deficiency in plasma caused by poor nutrition hinders phagocytosis, and this in turn results in an increased susceptibility to infections. Analogous to infections, acute and chronic inflammatory processes such as those in rheumatic diseases also have an effect on trace elements, e.g. on the redistribution of zinc in the body.

However, rheumatic diseases are not always ameliorated by zinc supplementation (like infectious diseases); it is therefore assumed that zinc acts in the context of a stimulation/inhibition homeostasis for phagocytes.(15 (9a) ).

Zinc supplementation (2 mg/kg) significantly accelerated the rehabilitation of immune status in malnourished children (15 (9a)).

Zinc and iron absorptions are positively correlated (15 (9b)).

Zinc deficiency induced necrosis of germ cell precursors, which leads to tubular atrophy and impaired spermatid differentiation (15 (9c) ). Zinc deficiency caused erythrocyte membrane changes: increase in total phospholipids and individual phospholipid classes (15 (9d) ). (This shows that zinc has an influence on lipid metabolism.) Patients with non-insulin-dependent diabetes mellitus have too low a plasma zinc level and too high a zinc excretion (15 (9e) ); further symptoms associated with zinc deficiency include impaired wound healing, ulcers on the legs and feet, poor taste perception, and impotence [- oral zinc intake was able to eliminate these.).

Description

Claim l^: (pulverized) crystal lattices for promoting

all listed homeostases

Piezomagnetic (e.g. Fe3C>4) or piezoelectric (e.g. S1O2) crystals emit magnetic pulses or electrical pulses when they start to vibrate (e.g. due to sound) (direct piezo effect). Conversely, electrical or magnetic vibrations radiated onto crystals cause such crystals to vibrate mechanically (reverse piezo effect).

Organs in living organisms (e.g. brain, heart, nervous system, muscles) also emit electrical (ECG, EEG) and magnetic (MEG, magnetograms of nerves and muscles) frequencies.

Bones can even convert mechanical energy into electrical energy (14 (3a) ); loading of bones produces electrical phenomena that are able to direct the activity of bone cells (14 (3a) ), and bones show semiconductor characteristics (14 (3a) ); weak direct electrical currents of λμα could orient collagen fibrils (14 (3b^) ), and more bone substance could be formed.

Magnetic fields affect the processes of coagulation and fibrinolysis as well as thrombolytic activity, cause an increase in prostacyclin, stimulate calcium modulus, affect calcium levels and calcium pumps, affect membranes, e.g. membrane permeability (14 (3d) ) (microwave permeability is associated with membrane phase transitions). An industrial alternating magnetic field provided evidence for the increase in fat utilization in the energy balance of the cell (14 (3e]_) ).

Muscles have dielectric properties (14 (5, p. 130 f.) ) (and are thus susceptible to electrical and magnetic forms of energy). Dielectric energy is generated during

of muscle activity from one structure of the muscle to the other:

Configuration energy and entropy are constantly redistributed to all organs and tissues (14 (5, p. 188)). For example, the dielectric energy in each myofibril depends on the dielectric constant; however, this is by no means constant, but depends on the intrafibrillar state of the water; if the dielectric constant has a high value, then the myoplasm behaves like a polar solvent, and water-soluble substances such as glucose and amino acids are transported and metabolized.

At a low value of the dielectric constant, however, the myoplasm behaves like a non-polar solvent and fats and other lipids are transported and metabolized, mitochondrial oxidation is stimulated, anaerobic glycolysis is suppressed or vice versa, and the RQ is reduced (standard resting conditions at low D). This makes it understandable that external magnetic and electric fields can intervene in the homeostatic regulation of the organism's negative free energy via the dielectric constant D.

Such fields are also used in many ways for healing purposes.

In addition, living organisms have magnetic susceptibilities (14 (4) ), which also leads to these

Organisms can exchange energy with magnetic fields, such as the paramagnetic radicals, so that radical homeostasis (see claim 5) can be influenced by magnetic fields (such as deactivation of radicals by releasing energy or activation of the respiratory chain by absorbing energy from fields).

Furthermore, permeability barriers (cell membrane epithelium, epidermis, endothelium) have electrical charges, so that

whose permeability can in turn be influenced by fields, such as the exocytosis of islet cells by magnetic fields, which leads to increased insulin release through magnetic pulsing. It is therefore obvious that the entire permeability homeostasis can react to magnetic fields (14 n(3d) ) and thus also the digestive system, the renal absorption and reabsorption mechanisms, i.e. the acid-base homeostasis.

If such considerations are pursued further, the conclusion that all homeostases can be influenced by the substances of claim 13 is obvious. In particular, metabolic systems of plants and animals can also be positively influenced by magnetic fields.

- &igr;&sfgr; -

RECIPE - EXAMPLES

On the basis of my claims and their justifications in the associated descriptions, there are practically any number of recipe examples if only substances are specifically selected from each claim. Special health interests can also be taken into account by putting together a mixture specifically for these.
It is a nutritional supplement intended to alleviate or eliminate the health consequences of an incorrect diet. ALL SUBSTANCES ADDED TO MY HOMOSTAT MUST BE DECLARED AS AVAILABLE FREE OF CHARGE IN FOOD STORES, HEALTH FOOD STORES AND/OR PHARMACIES.

When putting together a recipe - selection of the types of substance - based on my utility model application, you go through the individual claims one by one, starting from the beginning (page 4); when selecting the amounts of substance, you proceed according to certain generally known and applied guidelines (such as when preparing a tea), whereby it must be stressed that you can practically not make a mistake here - if you take it for granted that trace elements should only be present in trace amounts, vitamins only in small amounts - there are also international standards for mineral-trace element-vitamin mixtures, which are added as ready-made mixtures - and Glauber's salt and plants containing cardiac glycosides (only if they are freely available) should only be present as required and then only in small pinches.

To produce my homeostat from the selected substances, it is only necessary that the tea flowers, roots and
leaves are pulverized in a mill, as well as all selected substances not yet in powder form, and then thoroughly mixed with the previously sifted powders of all other substances (e.g. sifted vitamins, soya flour, corn flour, milk powder, etc.) and with the remaining bran until homogeneous.

Selection for a recipe example

The following were selected - as one recipe example from many possible -:

- For the effects of the selected substances, see immediately claims and description -

From claim 2; (p. 4)

Calcium citrate, magnesium citrate, potassium citrate,

sodium hydrogen phosphate, glutamine;

Bearberry leaves, mountain lady’s mantle, birch leaves,

Nettle, rueweed, goldenrod, green oats,

Restharrow root, lovage, dandelion, corn stigma,

Orthosiphon leaves, parsley root, rice, juniper berries,

Burnet root, celery fruits, barberry bark,

Willowherb.

From claim 3 (p. 8):

Vitamins A, C and E,
Phytate in flax seeds.

From claim 4 (S,

Nicotinamide,

Ginkgo biloba, motherwort (Leonurus cardiaca), mistletoe (Herba visci alba), hawthorn leaves and flowers (Crataegi· folium .et flores), Arnica flos, galangal root, cinchona bark, broom (Sarothamnus acoparius), periwinkle (Vincae minoris herbaJ soy, wild garlic leaves, willow bark (Salis cortex), pansy herb (Viola trie, herba), spirea, Primula radix, Hippocastani, ground ivy (Glechomae herba), speedwell (Veronica herba) {against bronchitis}, white soap root (Saponariae albae radix) {with expectorant and

-&eegr;-

anti-inflammatory effect}, Iceland moss, marshmallow root {expectorant and anti-inflammatory effects}, Echinacea {antibiotic and immunostimulating for the respiratory tract}, Gentianae radix, Primulae flos {immunomodulatory effect on the respiratory tract}, oak bark (Quercus cortex), Rhatania root (Ratanhiae radix) {against diseases of the mouth and throat}.

From claim 5 (pp. 2-€,20):

Seaweed, oyster mushroom, lapacho tea;

Thiamine, riboflavin, ascorbic acid, pyridoxine,

From claim 6 (p. 2^f):

Echinacea herba, . radix. (coneflower), Eleuterococci senticosi radix, mistletoe, lapacho bark {immune-inducing antitumor effect }, yew bark (Taxus brevifolia) {against melanoma, ovarian, breast and lung cancer}, marigold flowers (Calendula officinalis), arnica flowers;

reduced glutathione, fertilic acid, D-a-tocopherol, ß-carotene, dried algae (spirulina, dunaliella), phytic acid (inositol hexaphosphate) in linseed.

From claim 7 (SS. 2§", 2$):

Vegetable fibers, wheat bran, corn bran, starch, lactose, minerals (see claim 14), in particular those containing zinc, soya, reduced glutathione, amino acids in the known homeostatic profile (e.g. in gelatin), cysteine, phytate.

From claim 8 (page 2&psgr;) :

Soya flour (with natural amino acid profile, i.e. left natural), corn flour (and semolina), milk powder, starch, brown unpolished rice.

From claim 9 (p. 2gf): . . '

Black cohosh rhizome (Cimcifugae racemosae rhizomae) Chasteberry fruits (Agni casti fructus, Vitex agnus castus)

From claim 10 (see 3V):

Calamus root (Calami rhizoma), galangal root (Galangae rhizoma), black mustard (Sinapis nigri semen), gentian root (Gentianae radix), wormwood herb (Absinthii herba), cinchona bark.

From claim 11 ( p . 3Zf): ,

Calcium compounds in combination with vitamins and

Trisodium phosphate, black cohosh root,

Monk's pepper fruits. . .

From claim 12 (p.

Phytic acid (linseed), phosphate, ascorbic acid; internationally standardized trace element mix (especially with chromium, zinc, manganese, selenium).

From claim 13 (p. 35"):

Magnetite, rock crystal and rhodonite powder.

From claim 14 (p. 3 ¹ Jf):

For stomach protection:

Calamus, galangal root, black mustard, gentian root, wormwood, cinchona bark, linseed, marshmallow root, oak bark, ratania root, blueberries, Lactobacillus acidophilus, Escherichia coli, wheat bran;

For the rectum, anal area, against hemorrhoids: Hamamelidis folium et cortex, arnica flowers.

From the liver protection group:

Milk thistle fruits, agrimony (Agrimonia eupatoria)

From the bile protection group:

Barberry root (Berberis radix), wormwood, gentian root

Ir · *«·4&tgr;

Proportions

The guidelines given in the description of claim 8 were used as the basis for the proportions (see p. 77). According to these, proteins, fats and carbohydrates may only be consumed in such weight ratios that they provide equal energy contributions - i.e. one third of the total number of calories each - during their metabolic conversion.
For this recipe example, only the substances selected from claims 7 and 8 were included in this energy calculation.

The remaining selected substances made up a quarter of the homeostat weight, so that 1 kg of the finished homeostat mixture contains:

A total of 250 g of the substances selected from claims 1 to 6 and 9 to 14, of which 20 g each of calcium and magnesium citrates and 10 g of potassium citrate, 10 g of magnetite and rock crystal powder and 1 g of rhodonite (manganese carbonate) powder, as well as 1 to 10 g each of the pungent and bitter plants and finally 10 to 20 g of an internationally standardized trace element-vitamin-mineral mixture.

The remaining 750 g are filled with the substances selected from claims 7 and 8, taking into account the calorific guidelines (see description of claim 8 (p. 77)). . ·

All powdered components were then poured into a bucket with a tightly sealed lid, shaken vigorously and thus well homogenized.

This homeostat mixture, which has been repeatedly tested by a naturopath, has been found to be very good.

-10/-

My homeostat mixture is available as a dry powder spoon by spoon
It can be eaten with a glass of water and a bite of bread or can be mixed with all foods after they have been prepared; a special feature and novelty of my homeostat is that the teas do not have to be extracted first, but are eaten as tea powder, which leads to a delayed release of their active ingredients depending on the particle size distribution of their fibers.

Further recipes in line with this utility model application are planned, especially those rich in eicosapentaenoic acids. Until then, it is strongly recommended to take the homeostat recipe described with a few diced cubes of real raw salmon.

Claims (4)

Adolf Metz, Dipl.-Chem., Hauptstr. 8, 56814.JJirfus CLAIMS 1. Nutritional supplements for the universal restoration of disturbed homeostases characterized in that it contains the following natural ingredients: a) pH homeostatics {Buffer substances and natural substances that support the effect of buffer substances such as natural diuretics, natural complexing agents (anticoagulants), substances that influence the micellar structure, ion homeostatics, natural litholytics} b) Radical homeostatics or oxidant-antioxidant homeostatics {the organism's tolerance to natural substances that maintain oxidative stress such as radical scavengers (e.g. anthocyanins, vitamins, superoxide dismutases, reduced glutathione, catalase), redox enzymes (and substances that promote the body's own synthesis of endogenous redox enzymes, e.g. certain proteins) Ca ²⁺ homeostatics {Ions which competitively determine or influence Ca ²⁺ homeostasis (4.1, 4.8), Ca ²⁺ -dependent proteins (4.6, 4.7) - Ca ²⁺ buffers (4.12), Ca ^{2 +} chelators (4.12), natural antagonists of Ca ^{2 +} release into the cell interior (4.12)' natural substances to prevent calcification (4. 3 ) _/# natural anticoagulants, 'natural litholytics (4. 16-18), Ca antagonists (4.20) and natural substances against anoxia, hypoxia and ischemia (4.28)} Redox homeostatics {Substances that are able to maintain the reaction equilibria between the mitochondrial respiratory chain complexes and thus the mitochondrial energy storage (ATP production (5th - 2 40); optimize accumulation of Ca ²⁺ ions (as well as other ions: Mn ²⁺ , Sr ²⁺ , Fe ²⁺ ) against a gradient (5 29))} e) Immune response homeostatics {Substances for the homeostatic regulation of the metabolism of immune reactions} f) Permeability barrier homeostatics {Substances for the regulation of trans-epithelial (trans-endothelial) transport of substances in very different organs} g) Nitrogen, lipid, carbohydrate homeostatics {for the joint regulation of protein, fat and carbohydrate metabolism} Hormone homeostatics {Plants with hormonomimetic ingredients for estrogen-corpus luteum hormone homeostasis} Neural and receptor homeostatics {Substances for homeostatic regulation through nerves and receptors} j) Skeletal homeostatics {Regulators of resorption and new formation of bone tissue} k) Trace element homeostatics 1) Crystal lattice {with selected lattice constants to promote all homeostatic regulations} m) Plant protection groups {special plant groups to protect the stomach, intestines, liver and bile to strengthen their function and maintain their full homeostatic functionality} -4- Food supplement according to claim la, characterized in that ) its buffer substances are selected from &agr;) the CITRATES of potassium, magnesium and calcium, ß) the HYDROGEN PHOSPHATES of sodium and potassium and their tertiary alkali phosphates &ggr;) and also the METABOLIC AMMONIUM SUPPLIER GLUTAMINE (with glucose) and Na2SÜ4 (as Glauber's salt, as required) his DIURETICS are selected from Bearberry leaves Mountain lady's mantle Birch leaves Nettle Rupture herb Goldenrod herb Green oats Restharrow root Lovage Dandelion Corn stigma Orthosiphon leaves Parsley root Rice Juniper berries Burnet root1 Celery fruits -5- Angelica root Lespedeza herb Pansy Wheat herb Bird's knot Ichkraut Sarsapari11 root Asparagus root Cockgrass root Rose hips Blackcurrant leaves Hibiscus leaves Plants with diuretic effects by IMPROVING HEART PERFORMANCE: Squill Hellebore Thea sinensis DIURETICS. Spasmolytics and spasmolytics (AGAINST STONE DISEASES): Ammei fruits Barberry bark (also for GOUT) Celandine Belladonna (root, leaves) Butterbur Berberis vulgaris.h omöop.at i sch Lycopodium clavatum, homeopathic -b- EXPECTATIONS. Chemol itholyt.ika (for STONE DISSOLUTION): Potassium sodium hydrogen citrate (against URIC ACID STONES, less against CY. S TIN STONES) Plants with EFFECTIVENESS AGAINST BENIGNE PROSTATE HYPERBLASIA Pumpkin seeds Nettle root Saw palmetto fruits Poplar bark, leaves Willowherb Hypoxis root African prunus bark Pollen Plants effective against MICTATION DISORDERS: Pumpkin seeds ^; Spice sumac, Kawa-Kawa root, Hop cones, St. John's wort, Valerian root -7- PfIa &eeacgr;&zgr; en with EFFECTIVENESS AGAINST URINARY TRACT INFECTIONS (URINARY ANTISEPTICS): Bucco leaves Bearberry leaves Sandalwood Nasturtium Horseradish homeopathic: Chimaphila umbellata Equisetum hiemale Fabiana imbricata Pulsatilla pratensis FURTHER Glauber’s salt (as needed) -8th- -8th- Food supplement according to claim Ib), characterized in that its protective effect against a harmful excess of radicals is made possible by: a selection of vitamins against oxidative stress, especially vitamins A, C and E; anti-cancer retinoids (3. (17)) and "doped" ß-carotene (3(18 ) ) ; a selection of enzymes against oxidative stress, in particular through a selection of superoxide dismutases, catalases and glutathione reductase (3 (8);' a selection of trace elements that are functional central atoms of superoxide dismutases, in particular manganese and chromium; a selection of proteins effective against oxidative stress, in particular albumin (3 (3 ) ), glutathione reductases, glutathione S-transferases (3 (6)), glutathione synthetases (3 (7)); a selection of chelators for Fe^ ⁺ , in particular phytic acid (inositol hexaphosphate) to prevent oxidative injury after postischemic reperfusion (oxygen paradox) (3 (2)); a selection of anthocyanins, especially beetroot pigments; {The ingredients of this group are partly contained in protein-vitamin concentrates that can be gently produced from suitable green nutritional plants (3 (19)). -9- CLAIMS 4.A) Overview: Food supplement according to claim lc), characterized characterized in that disturbances of Ca ²⁺ homeostasis as well as ischemia and hypoxia are counteracted by a selection of: a) CIRCULATION-PROMOTING NATURAL plant substances b) BREATHING-PROMOTING NATURAL plant substances C)NATURAL ANTICOAGULANTS d) FISH FATS and calcium -homeostasis regulating ingredients from marine animals (e.g. calciferol in salmon and eel) {very low incidence of ischemic heart disease in Eskimos} In detail: To 4 a Ginkgo biloba Leonurus cardiaca (Motherwort) Herba visci albi (Mistletoe) Crataegi leaf and flower (Hawthorn leaves and flowers) as well as : Nicotinamide further &agr;) coronary-active and circulation-promoting CARRICULUM GLYCOSIDE-CONTAINING 'plants; Lily of the valley herb Adonis herb 01eander leaves Squill Red foxglove ß)NON-CARBON GLYCOSE CONTAINING PLANTS Arnica flos Cacti flos Ammi visnagae fructus Camphor Cammellia sinensis, tea plant leaves Papaver somniferum Ginger root Pepper fruits Galangal root Cinchona bark{against heart rhythm disorders} Rauwolfia root {against heart rhythm •muscle disorders} Common broom (Sarothamnus scoparius) Atropa belladonna Vincae minor is herba) Aesculus (anti-edematous) Ginkgo folium Rauwolfia radix {arterial hypertension}; Olive leaves Against hypotonia Kola nut (Cola nitida) Tea leaves (Thea sinensis) Sea urchin Broom herb Rosemary leaves Type er iosk 1 erosion prophylaxis, against hyperlipidemia Garlic Oat bran pectin Wild garlic leaves Guggul onion Salicylic acid plants Willow bark (Salix cortex) Pansy herb (Viola trie, herba) Spiraeaae flos, herba) Primula radix Against migraines Yellow Jasmine Against migraines Yellow Jasmine
Chrysanthemum parthenium For venous diseases Hippocastani semen, (edema protection iv} Rusci aculeatiS radix{edema protection iv} Meliloti albi herba (sweet clover) (increases lymph flow, tones veins.d} Hamamelidis virginianae folium (astringent} Solidago {diuretic} Broom{improves the flow dynamics, in the V a r i &zgr; e &eegr;} HOMEOPATHY Heart homeopathic remedies Aconitum napellus (D 12) {night-time heart problems, palpitations} Adonis vernalis (D 3)(P u Apocynum cannabinum(D 2){edema} Convallaria majalis{P u 1 s} ■ Digitalis(D 6){dizziness, weakness- chegefühl·}- Iberis amara(D3)[Candyflower](H e r &zgr; b e schwerden when lying on the left side} Kalmia latifolia(D 4)("t umultart ige Heart action} Leonurus cardiaca(D 3){functional heart problems} Lycopus virginicus(D3)(Rhythm stabilization of the heart function} MyrtillocactusfD2){stinging heart pains in anginal attacks}· Prunus laurocerasus(Laucerasus)(D2)(no rapid pulse in _nocturnal congestive bronchitis} Selenicerewus grandiflorus(Cactus)(D3) {strong precordial pressure sensation} Sigelia anthelmia(D6){ burning heart pain, irregular pulse} CIRCULATORY HOMEOPATH IKA Arnica montana(D12){Hypertensionwith ringing in the ears, dizziness, nosebleeds} Cytisus scoparius(Spartium scoparium](d2) {Extrasystole ie} Crataegus(D4){functions on vegetative heart problems and circulatory disorders} Haplopappus baylahuen(D2){Dizziness, blacking out of the eyes when standing, cold hands and feet} Nicotiana tabacum (Tabacum)(D6){Circulatory disorderswith dizziness and nausea} Veratum albbum(D4)5{too high pulse, pale and cold sweats} Artemisia abrotanum (Abrotanum)(D3){p r i phere circulatory disorders} Espeletia grandiflora (D3){ formication and feeling cold} VENOUS HOMEOPATHICS Aesculus hippocastanum (D4,D6){Swelling of the legs with pain, Thrombosis} Hamamelis virginiana (D4){b touch-sensitive Var &zgr; e &eegr; b e i ification to recurrent bed &eegr; g t e r &ngr; i e - lebitides N o P. h ¹ lebitiden, in pregnancy varicose veins is} Melilotus officinalis (D4){r e.z i d i rende thromboph beiVaricosis} Pulsatilla pratensis (D12){ chronic venous insufficiency with pre-climacteric symptoms, CLOSE RELATIONSHIP TO THE FEMALE HORMONE BALANCE} E - MIGRAINE HOMEOPATH IKA Cimcifuga racemosa (D6){ migraine-like headaches associated with cervical spine, shoulder-arm syndromes, myocardium}
Cyclamen europaeum (D6){ Migraine with double vision, flickering, flickering in front of the eyes, dizziness, also with PREMENSTRUAL SYNDROME} Digitalis purpurea (D3) {Migraine with nausea and color vision} Gelsemium sempervirens (D6) {for migraine dizziness} Iris versicolor (D6) {periodic migraine attacks with vomiting and diarrhea} Sanguinaria canadensis (D6){for migraine with hepatopathy} Food supplement according to claim Ic), characterized in that the plants for protecting the RESPIRATORY TRACT are selected from the following: Against bronchitis with expectorant effect Pulmonariae herba (lungwort) . Castaneae föl. (sweet chestnut leaves) Glechomae herba (ground ivy) Hysopii herba (hyssop)
Verbenae herba (Verbena) Veronica herba (Speedwell) with expectorant and antiphlogistic effect Primulae radix (primrose root) Senegae radix (senega root) Saponariae rubrae radix (common soapwort) Saponariae albae radix (white soaproot) Liquiritiae radix (liquorice root) Violae tricoloris herba (pansy herb) Hederae folium (ivy leaves) Hippocastani semen.(horse chestnut seeds) • * 4 b) (see overview on page 10) mucilaginous Iceland moss ribwort plantain marshmallow root antibiotic immune stimulating for the respiratory tract Echinacea Tropaeoli herba (nasturtium) Armoraciae radix (horseradish) Against symptomatic cough Droserae herba (sundew herb) {effective, η g spasmolytic, antiphlogistic ic, antibiotic due to the content of the 1,4-naphthoquinone derivatives ramentaceon, droseron, plumbagin} species e.g. D. rotundifolia, D. ramentacra Ephedra vulgaris·(Ephedra herb) Thymus serpyllum (thyme) Pinguicula (butterwort) Eryngium planum (sea holly) Ledum palustre (marsh tea) Against bronchial asthma Ephedra herba (sea grape herb) Ammi visnagae fructus and herba (true Ammei fruits) Allii cepae bulbus (onion) Against oto-rhinopathies Chamomillae flos (chamomile flowers) Immunomodulator is effective: Gentianae radix Primulae flos Rumicis herba Sambuci flos Verbenae herba Against diseases of the mucous membranes and throat area Salviae folium (sage leaves) with tannin Quercus cortex (oak bark) Rhei radix (rhubarb root) Ratanhiae radix (rhatania root) Tormentillae radix (tormentil root) Potentilla tormentilla ••••a · ··· HOMEOPATHICS In acute bronchitis Bryonia cretica (D6) {for coughing with severe chest pain} Drosera (D6) {Cough with difficulty breathing} Euspongia officinalis (Spongia) (D4) {Cough with shortness of breath and hoarseness.} Hedera'helix (D6) {R e i &zgr; h u s t e &eegr; with 'Flu-cold} Hyoscyamus niger (D4) {nighttime coughing with significant worsening when lying down} Rumex crispus (D4) {painful and spasmodic cough} further Cuprum aceticum (D4), (D6) In chronic bronchitis Cephaelis ipecacuanha (Ipecacuanha) (D6) {for asthmoid bronchitis with severe nausea and vomiting} Hydrastis canadensis (D3) {for persistent coughing with throat clearing} Lobaria pulmmonaria (Sticta) (D6) {painful cough} Oenanthe aquatica Phellandrium) (D4) {for cough with viscous sputum} Polygala senega (Senega) (D4) {cough with chest pain, dyspnoic picture, especially in old age emphysema} further mineral
Stannum jodatum (D 6) (D 12)
Sulfur iodatum (D 6) (D 12)
■ . Dactylopius coccus [Coccus cacti] (D4) (D6) '&tgr; · · · * mat For Bronchial Asthma Aralia racemosa (D4) (D6) (cough with foreign body sensation in the throat, shortness of breath when lying down) Datura stramonium (Stramonium) (D 12) (for spasmodic cough.&eegr; with hoarse voice} Grindelia robusta (D4) (D 6) (shortness of breath with poorly soluble mucus, coughing fits) Lobelia inflata (D4) (D 6) (R e i &zgr; c u s t e &eegr; with increasing spasticity and shortness of breath, circulatory instability} - . Solanum dulcamara (Dulcamara) (D4) (D6)(a s t h moide Conditions due to DAMP COLD}· further mineral
Silicic acid (Silicea)
CaIc. carb.
Cuprum metallicum
IODUM Kalium sulfuricum
Sodium sulphuric For rhinitis, sinusitis, otitis All ium cepa (D4) (D6) ,{aqueous sensation with.subjunctive ' i t i s} Atropa belladonna (D4) (D6) (severely reddened mouth and throat mucus, skin, earache) Euphrasia officinalis (D3) (D4)(Conjunctivitis with burning secretion} Galphimia glauca (D4) (D6) (ALLERGIC rhinitis and conjunctivitis) Luffa operculata (Esponjilla) (D6) (D 12) (for painful nasal cavities, headaches, mucous membranes in the throat) Phytolacca americana (D4) (D6) (difficulty swallowing, subfebrile temperatures} Thuja occidentalis (D12) (respiratory infections with viscous nasal secretion) ■·· · i further mineral
Ferrum phosphoricum (D6) (D12)'{&Igr;&eegr; fects d e r i v. a t e m w e ( e G e. { R { H k i r &eegr; i t i s. c h i- O t i t i s} r [Ka] L ium bichromicum ( D6 ) ) S i &eegr; U - B r&ogr; e &zgr; i- t {i} e e {n} Calcium carbonicum D 12 C H r n. - r d At e m w G S a n k u &eegr; 4c) ■ Food supplement according to claim Ic), characterized in that its anticoagulants are selected from natural substances such as: Citric acid, sodium citrate, dextrose to prevent solid deposits caused by excess calcium, litholytics; Food supplement according to claim 1 c), characterized in that the actual Ca ²⁺ homeostasis regulating substances are selected from components such as: a) ions which competitively facilitate Ca ²⁺ homeostasis, selected from Na^ ⁺ (4 (I)), K ⁺ (4 (2)), Mg ²⁺ , H ⁺ (regulated by pH) (4 (1) ) and antihyperglycemic substances such as insulin and chromium (4 (1) ); b) Ca ²⁺ -calmodulin-dependent protein kinases (, e.g. contained in brain,) (4 (6) ) ■ .{important for the function of nerve cells} c) Kaimodul in and vitamin D (1,25-dihydroxy-vitamin D3) {important for the regulation of the ATP-dependent duodenal Ca ²⁺ pump (4 (7) )} {contained e.g. in fish (salmon, calciferol)} d) Natural selective AMPA receptor antagonists (non-N-methyl-D-aspartate antagonists) to prevent lethal Ca ²⁺ immigration into brain cells (4 (12) ), natural Ca ²⁺ channel blockers, free radical scavengers, protease inhibitors, blockers of certain membrane inhibitors such as opiate antagonists, glutamine receptor blockers to prevent lethal Ca ²⁺ immigration into cells (especially in nerve and brain cells), cell-permeating Ca ²⁺ chelators (overview see 4(12), Table 1) e) Cytoplasmic Ca ²⁺ buffers
¹ such as calmodulin, kalbindin, parvalbumin (4 (12, p.1179 EXPECTATIONS Food supplement according to claim 1, characterized in that it contains: .a) (in case of defective respiratory complexes) the respiratory chain bypasses producing
1.4-B ENZOQUINONE ANALOGUES α )■ Ubiquinone, coenzyme Qiq (ubidecarerion) (with ten isoprene units) Plants containing plastoquinone (chlorophyll, chloroplast), e.g. algae Bovichinone-containing plants (mushrooms): Cow's bolete (Su i111us bov i nus); Chroogomphus species (Basidiomycetes) (5 (15)) Oyster mushroom ß) Vitamin K3 (Menadione) &ggr;) Vitamin K^ (phylloquinone, phytonadione) &dgr;) Vitamin K2 &egr;) Idebenone (5 (6)) and calcium hopantenate (5 (6)) together with coenzyme Qiq (5 (8) and the following 1,4-NAPHTOQUINONE DERIVATIVE CONTAINING plants: LAPACHO TEA SUNDEW HERB (DROSERAE HERBA) .VENUS FLYTRAP (DIONAEA MUSCIPULA) b) glutathione reductase-containing plants (5 (24)) c) the REDOX vitamins the redox vitamins α) Thiamine (Vitamin B^) β) Riboflavin (Vitamin B2 ) &ggr;) Ascorbic acid (vitamin C) &egr;) Pyridoxine (vitamin B) A selection of plants (and other natural substances) containing the substances listed under claims 5a) to 5c). Naturally occurring substances that lower plasma lactate levels and normalize the lactate:pyruvate ratio, e.g. selected from 1,4-benzo- and naphthoquinone derivatives f) Substances which promote the lateral (specific, membrane-associated) diffusion (in the plane of the mitochondrial membrane) of respiratory chain 1,4-quinones (e.g. ubiquinone: ubiquinone is unbound and freely mobile during electron transfer (5 (5), p. 10 790)) and the respiratory chain complexes I, �P and M for the purpose of promoting diffusion-controlled electron transfer (5 (5)), selected from non-toxic membrane-permeating solvents for 1,4-quinones (corresponding to chloroform (5 (.5), p. 10 790) for better distribution of reduction equivalents between independently diffusing membrane dehydrogenases and the cytochrome Bci complex. EXPECTATIONS Food supplement according to claim Ie), characterized in that the NATURAL substances maintaining immune tolerance are selected from: Plants for IMMUNE STIMULATION. Echinacea herba, radix (coneflower) Echinacea purpurea, E. pallida, E. angustifolia {increase in properdin levels, leukocyte and granulocyte counts, phagocytosis index, has immune-induced antitumor effect} Eleuterococci senticosi radix (Eleuterococcus) Eleuterococcus (Acanthopanax) senticosus {a d a pt ogen, stress-reducing} Eupatorii perfoliati and E. cannabini herba [Red waterhemp and water agrimony] Eupatorium perfoliatum and E.cannabinum {increase in the phagocytosis performance of granulocytes, a &eegr; t ip hlogistic} Baptisiae tinctoriae radix [Wild Indigo] Baptisia tinctoria {s stimulating phagocytosis and T-lymphocyte proliferation} Thujae summitates [American arborvitae, branch tips] Thuja occidental is {stimulates human monocytes and lymphocytes to release Iηte rleukin 1 and 2}' Visci albi [Mistletoe]
Viscum album {for therapy - MALIGNANT TUMORS, stimulates NK cells for cytotoxicity, tumor necrosis factor a, interleukin 1 and 2 are released by monocytes} 2 2.- CLAIM ₁ 6. ■ Dionaea muscipale [Venus flytrap] herb {immune-stimulating anti-tumor effect; the active ingredients plumbagin and other naphthoquinones have an immune-stimulating effect in high dilutions (10~9-10~12 g/L), therapeutic success} Tabebuia avellanedae, lapacho bark {immune-inducing antitumor effect} Catharanthus roseus (= Vinca rosea) roots and leaves {Active ingredients: vinblastine and vincristine; acute lymphatic leukemia, M, Hodgkin, lymph sarcoma, lymphogranulomatosis, testicular tumor, breast cancer, ovarian and choriocarcinoma γ m '} Podophylli rhizoma, Podophyllum peltatum (resina) (foot root) {Active ingredients: podophyllotoxin, peltatin; for Condylox, Condyloma acuminata} Taxus brevifolia (yew bark) {Active ingredient: taxol; Melanoma, ovarian, breast and L rough &eegr; g e &eegr; -Ca} Plants containing diallyl sulphide such as garlic (Allium sativum), wild garlic {prevent cancer . (6(7))} Arnica flos, arnica flowers (Arnica officinalis) Calendula flos, marigold flowers Calendula officinalis Chamomillae flos, chamomile flowers . Chamomilla recutita Achyrocline herba (Achyrocline saturoioides), "Brazilian chamomile" {with immune-stimulating polymers} ·· EXPECTATIONS
6.1 Antitumor fungi (6(2)) Medicinal yeast, Saccharomyces cerevisiae, S. carsbergensis (Activation of phagocytosis and the complement system, stimulation of T-lymphocyte proliferation, increase in lysozyme levels} Lentinus edodes {with Lentinan, . immune inducing, involving macrophages, T lymphocytes, complement, NK cells and interleukins; in adjuvant therapy up to 50% regression of lung, cervical and stomach carcinoma
and colon cancer (6(2))} Schizophyllum vulgaris {Effect equivalent to that of Lentinan; success in adjuvant cancer therapy in Lung cancer, uterine cancer, stomach cancer}
Ginseng radix (ginseng root) Off.:Panax Ginseng {immune stimulant, has
.neuroprotective activity (6 (6))} HOMEOPATH I KA {for swelling of the lymph glands Helianthemum canadense (Cistus canadensis) (D4) Teucrium scorodonia (D4) Immunomodulating (and/or corticomimetic) anti-rheumatics -ZH- EXPECTATIONS Dietary supplement according to claim "le), characterized in that natural substances for regulating the tumor necrosis factor (TNF) effect (avoidance of TNF-induced excessive oxidative stress) are selected from: · Reduced Glutathione Fertulinic acid (with antioxidant effect), contained in corn, wheat bran, barley and D-a-tocopherol (antioxidant), ß-carotene: may induce TNF secretion by blood monocytes and tissue macrophages, Canthaxanthin, dried algae (spirulina, dunaliella), Phytic acid (inositol hexaphosphate), contained in plant seeds (e.g. flax seeds) {complexes active iron in the intestine, reduces cell proliferation} - Eg- EXPECTATIONS
7. Food supplement according to claim If), characterized in that its epithelial homeostatics are selected from: &agr;) intestinal epithelial homeostatics, Substances which contribute to the maintenance of well-regulated intestinal epithelial function, selected from: anti-colon tumor active substances vegetable FIBERS Wheat bran Corn bran ((jj_5)-FATTY ACIDS (in fish fat, e.g. from SALMON) with zinc PHYTIC ACID (to chelate reactive iron) {found in plant seeds} STARCH and other DIGESTIVE carbohydrates such as LACTOSE MINERALS (claim 14).
further SOYBEANS and other PROTEIN-CONTAINING foods [prealbumin and albumin-containing] {against OXIDATIVE N STRESS5} &bgr;) Vascular endothelial homeostatics substances that regulate the circulatory and lymphatic system: Substances necessary to prevent arteriosclerosis, selected from the ENDOTHELIAL ANTIOXIDANT SYSTEM Amino acids (in the known homeostatic profile) Glutathione (as REDOX tripeptide ' and bound to REDOX PROTEIN) &ggr;) Brain (nerve) ENDOTHELIAL -. Homeostatics REDUCED Glutathione (PRODUCES reduced cysteine] -Zi EXPECTATIONS 7.
&dgr;) Lung epithelial homeostatics Nucleophiles that restore the oxidant-antioxidant balance disturbed by electrophiles: {Glutathione -Cysteine - HOMEOSTASIS:} REDUCED Glutathione REDUCED Cysteine {vital for lymphocytes and erythrocytes in the lungs} &egr;) Permeability barrier homeostatics Natural substances that restore barrier disorders, selected from: Palmitic acid Adipic acid Phospholipids Reduced Glutathione Zinc ' Phytate (inositol hexaphosphate) Biotin Hyaluronic acid EXPECTATIONS
8th. Food supplement according to claim Ig), characterized in that its nitrogen-lipid-carbohydrate homeostatics are selected from: &agr;) SOY FLOUR remained natural, with natural amino acid profile
but supplemented with methionine and threonine ß) Freeze-dried STOCKFISH {very low cancer rates and coronary diseases among Greenland E skim &ogr; s, caused by FISH PROTEINS and FISH FATS with &OHgr;-5-FATTY ACIDS, PENTAENOIC ACIDS} &ggr;) FISH FATS, but less than 30% of the total calories consumed {rich in eicosapentae &eegr; acids, which have an anti-cancer and anti-coronavirus effect, {The entire NITROGEN HOMEOSTASIS is regulated by these fish fats, which are ingested with PROTEIN food in that this ensures OPTIMAL USE of NITROGEN SOURCES by the organism } &dgr;) Milk powder &egr;) Fibre-rich plants, vegetables, bran, fruit, {"muesli"}, cereals, starches, semolina from brown unpolished rice, &zgr;) SELENIUM-CONTAINING plants: GARLIC, BROCCOLI, (wild garlic) CLAIMS-9. Food supplement according to claim lh), characterized in that its components - ALSO SUITABLE FOR BATH USE A) WITH ESTROGEN-LIKE EFFECT selected from: α) Cimcifugae racemosae rhizomae (radix) (Black cohosh rhizome) Cimcifuga (Actea) raceraosa (North American bugweed rhizome) {HORMOMIMETIC ESTROGEN-LIKE EFFECT} (Also suitable for bath use (9 (9, p. 313)) ß) Rhei rhapontici radix (Rhapontic, monk or Pontic rhubarb) Rheum rhaponticum (Monk’s rhubarb root) {HORMOMIMETIC, weak estrogenic effect due to rhaponticin, a stilbene glycoside, laxative effect due to anthraquinone glycosides} &ggr;) Hops (estrogen, sedative) B) WITH CORPUS LUTEUM HORMONE-LIKE EFFECT selected from: Agni casti fructus . (Chasteberry fruits) Vitex agnus castus (Chasteberry or Chasteberry fruits) ~ 2.9 - CLAIMS 9. C) HOMEOPATHY Pulsatilla pratensis (D12) {u &eegr; r e g e 1-moderate period bleeding, premenstrual complaints , mastodynia} EXPECTATIONS Food supplement according to claim Ii), characterized in that a) the plants whose ingredients trigger olfactory, gustatory or skin stimuli via nerves and can thus bring about HOMEOSTASIS, are selected from: a)Essential oil plants: Peppermint leaves (Menthae föl. ), fennel fruits (Foeniculi fructus), caraway seeds (Carvi fructus), aniseed seeds (Anisi fructus), coriander seeds (Coriandri fructus) Angelica root (Angelica radix), cardamom fruits (Cardamomi fructus) Chamomile flowers (Chamomillae flos) ß) Hot plants: Calamus root (Calami rhizoma), galangal root (Galangae rhizoma){a ntiphlogistic h}, ginger root (Zingiber of f icinal is ), garlic (Allii sativi. bulbus), other Allium species, e.g. Allium cepa, black mustard (Sinapis nigri semen), white mustard (Sinapis albae), candytuft (Iberis amari herba, semen; bitter mustard) TJBitter substance plants' Gentian root (Gentianae radix), wormwood (Absinthii herba) ■ Centaury (Centaurii herba), bitter orange peel (Aurantii pericarpium), Jamaica bitterwood (Ouassiae lignum) Blessed herb (Cnici benedicti herba), cinchona bark (Chinae cortex), condurango bark (Condurango cortex) Chicory root (herb) (Cichorii radix; herba) b) NaCl HOMEOSTASIS can be achieved by IRRITATION OF THE LIVER NERVES (in the presence of a lot of NaCl); c) membrane receptor homeostasis can be adjusted as described. -31 - •••&phgr;* · · · · 11. CLAIMS Food supplement according to claim Ij), characterized in that its skeletal homeostatics are selected from Vitamin D (in fish oils) with its metabolites l-a-0H-D3 {effective against osteoporosis: Increase in bone mass, decrease in bone fractures} Calcitriol {effective in corticosteroid-induced osteoporosis} Further: Calcium, Ca, in combination with trace elements, vitamins and trisodium phosphate {the combination treatment reverses bone loss} Calcitonin (in salmon, eel; also in powder form mixed with glucagon) {effective postmenopausally; effect by stimulating the endogenous opioid system, improvement in bone pain; improvement in bone density and strength as parathyroid hormone (PTH-! antagonist} Plants that are effective against osteoporosis of the menstrual cycle Cimcifuga racemosa rhizoma (radix) (Black cohosh root) {has a hormone mimetic ESTROGEN-LIKE effect} Agni casti fructus (chasteberry fruits) {has a hormono-mimetic CORPUS-LUTEUM-LIKE effect on pre- to postmenopausal osteoporosis} Insulinotropic plants Anemarrhena asphodeloides (Liliaceae) {ant idiabet i see and diuretic Effect, Chinese and Japanese folk medicine} Plants containing SUCCIN ACID ESTERS {these have insulin secretagogue effects} A) Food supplement according to claim 1 k), characterized in that the substances causing a competitive interaction in trace element homeostasis 1.) inhibitory ligands selected from: Phytic acid, phosphate, tannins, avidin, ' fiber, oxalic acid, proteinase inhibitors, thiaminase; 2. ) promoting ligands
selected from: citric acid, ascorbic acid, sulphur-containing amino acids; 3.) that the competitively interacting trace elements themselves selected from the pairs: Zinc - copper, iron - zinc, calcium - iron, copper - iron, zinc - cadmium; 4.) and that further trace elements are selected from: . . Chromium {has insulin-like effect, can Increase skeletal muscle growth, has a positive effect on glucose homeostasis , has a positive effect on long-term exercise training, on glucose utilization and muscle growth, - 3 3 - shifts the isomyosin profile of the heart, but has no destructive effect on cardiac tissue or cardiac protein content} Zinc { has a beneficial effect on fatty acid metabolism, promotes the incorporation of polyunsaturated fatty acids into tissue lipids, plays a role in the desaturation of essential fatty acids, and consequently influences the synthesis of prostaglandins and membrane properties such as fluidity, permeability, fragility and the activities of membrane-bound enzymes}. . Manganese {, affects lipid metabolism and cholesterol synthesis because it acts as a cofactor of mevalonate kinase and farnesyl pyrophosphate synthetase, two enzymes necessary for cholesterol synthesis, i.e., by reducing manganese intake, cholesterol synthesis in the liver can be reduced,} Selenium {is 95% bound to serum proteins; three selenium-containing plasma proteins identified so far: selenoprotein P, selenium-containing glutathione peroxidase, selenoalbumin bound to cysteine, methionine and glutathione (15SeI); selenium is therefore absorbed with proteins; in cases of kidney disease, selenium concentrations are reduced (15Se2) Dietary supplement according to claim 11), characterized in that the crystal lattices with selected lattice constants (in powdered form)' to promote and supplement all homeostatic regulatory processes are selected from: Magnetite, Fe3<34 (piezomagnetic) Rock crystal, S1O2 (piezoelectric) Rhodonite, MnCC>3
(Lapis Lazuli) 14. . · Food supplement according to claim lifn), characterized in that the plant-protective groups for supporting homeostatic organ functions are selected from: a) The stomach protection group Peppermint leaves (spasmolytic, cholagogue, carminative) Fennel fruits (spamolytic, secretolytic, carminative) Caraway fruits (spasmolytic, antibacterial, carminative) Anise fruits (spasmolytic, secretolytic, antibacterial) Coriander fruits (spasmolytic, carminative) Cardamom fruits (cholagogue, carminative) the spicy plants (including mustard oil plants): Calamus root (carminative) Galangal root (spasmolytic, anti-inflammatory, antibacterial1, carminative) Ginger root (spasmolytic, cholagogue, antiemetic, carminative) Garlic (antibacterial) Black mustard (bacteriostatic) White mustard (bacteriostatic) Candytuft herb (bacteriostatic, carminative) and digestive bitter plants Gentian root (bitter value: 10,000 - .30,000), wormwood (bitter value: 10,000- 25,000), Centaurine (bitter value: 2,000 - 10,000) bitter orange peel (bitter value: 600 - 2,500) Jamaica bitterwood (bitter value: 40,000 - 50,000) blessed thistle (bitter value: 800 - 1,500) Cinchona bark (bitter value: approx. 1,000) Condurango bark
Chicory root (herb) further plants against acute and chronic gastritis and ulcer diseases: Chamomile flowers and the slime plants Linseed, marshmallow leaves, marshmallow root, mallow leaves acute and chronic diarrhea Crohn's disease, ulcerative colitis, diverticulosis Essential oil plants with effect on irritable bowel syndrome: Peppermint leaves, fruits of caraway, fennel, anise and Asa foetida: Ferula foetida Antidiarrheals with astringent effect: Oak bark (Quercus cortex: Quercus robur) Tannic acid (Acidum tannicum) {contains 8-20% tannins: catechins and ellagitannins; also gallocatechins, gallotannins and leucoanthocyanidins} Tormentil (bloodroot) (Tormentillae radix: Potentilla erecta) {contains 15-10% catechin tannins (tormentil binders and tormentil red), ellagic acid and hydrolysable tannins, also triterpenes (quinic and tormentillic acid as well as tormentoside) Ratanhia root (Ratanhiae radix: Krameria triandra) {8-12% catechin tannins: ratanhia tannic acid, ratanhia red} Blueberries (Myrtilli fructus: Vaccinium myrtillus) {contains 5-10% catechins and "anthocyanins"} Tea leaves (Thea folium; Camella sinensis) {catechin and gallocatechin tannins, 2.5-4.5% caffeine, theophylline, theobromine, essential oil} * Antidiarrheals with adsorptive and stool-thickening properties Pectins (Citrus, Pirus and Malus species) {contain hydrocolloids, composed of polygalacturonides} Carob seeds (Ceratoniae semen: Ceratonia siliqua) {Pectin mucilage, sucrose. Invert sugar} Salep tubers (Orchis species) {with mucus from glucomannan and glucans} Indian psyllium (Plantaginis ovatae,c PhylliiD semen: Plantago afra, ovata and similar species) {10-25% neutral and acidic mucilages (heteroxylans)} ' Antidiarrheals of microbial origin: Saccharomyces species: Saccharomyces boulardii (= S. cerevisiae Hansen C CBS 5926D = ScH CBS 5926) {originally a tropical wild yeast strain; this regenerates and stabilizes the natural intestinal flora by preventing and curing the settlement of exogenous pathogenic germs, e.g. Albica albicans, Shigella, Proteus or Pseudomonas bacteria, and at the same time promotes the growth of physiological intestinal bacteria.} Lactobacillus acidophilus: Lactobacterium acidophilum and bifidum Escherichia coli bacteria: Streptococcus faecalis, Bac. subtilis ' Plants for acute and chronic constipation (These can be added to my homeostat as an alternative to the antidiarrheals if desired) Laxative anthranoid plants: Aloe; Cape or Barbados Aloe: Aloe ferox, A. barbadensis, A. spicata and hybrids {contains aloemodin-anthrone-_C-glycosides (aloin A, B, aloinosides A, B), also aloin resins} Buckthorn bark (Frangulae cortex: Rhamnus frangula, adulteration: Rhamnus fallax) {contains the anthraquinone glycosides glucofrangulina and B and frangulins A and B, as well as glucosides of emodin, physcion and chrysophanol} American buckthorn bark or Cascara sagrda bark (Rhamni purshiani cortex: Rhamnus purshianus) {contains cascarosides (cascarosides A, B, C and D) as well as aloin and chrysaloin and glycosides of aloe-emodin, emodin and chrysophanol as hydroxyanthracene derivatives} Buckthorn berries (Rhamni catharticae fructus: Rhamnus catharticae) {contains hydroxyanthracene compounds (emodin-anthrones/ and anthraquinones), as well as coloring flavonol glycosides} Senna leaves and pods (Sennae folium and fructus: Cassia angustifölia, C, sennae) {contains dianthrone glycosides with sennosides A, B, C and D as well as aloeemodin and pure monoglucosides.} Rhubarb root (Rhei radix: Rheum palmatum, Rh. officinale Adulteration: Rheum rhaponticum) {contains anthraquinone glycosides, including glycosides of rheumemodin, aloe-emodin, rhein, chrysophanol and physcion; dianthrone glycosides and tannins} Plants with laxative resins: Jalapeno root (Jalapae turbae tuber: Ipomoea purga) {contains glycoside resins (glycoresins)} Scammonia root (Scammoniae radix: Ipomoea orizabensis, Convolvulus scammonia) {contains glycoside resins (glycoresins)} Colocynths (Colocynthidis fructus: Citrullus colocynthis) {contains cucurbitacins} * Laxative herbal fillers and swelling agents '."■'■ Psyllium (Phyllii semen: Plantago afra, ovata, arenaria and psyllium) {contains neutral and acidic mucilages, consisting of xylose, Arabinose, rhamnose, uronic acids and other sugars.} Linseed (Lini semen: Linum usitatissimum) {contains fatty oil, acidic mucilage, consisting of galactose, arabinose, xylose, rhamnose and uronic acids, as well as cyanogenic glycosides} Tamarind pulp (Tamarindorum pulpa: Tamarindus indica) {contains invert sugar, pectins, fruit acids} Figs (Caricae: Ficzus carica) {contains invert sugar, mucilage, pectin and fruit acids} Wheat bran (Triticum aestivum) {Approx. 63% carbohydrate content, consisting of: pentosans and hemicellulose, starch and mono- and oligosaccharides} Agar (agar-agar: Gelidium, Ahnfaltia species) {contains polysaccharides consisting of agarose and acidic agaropectin, which consists of galactose and Galacturonic sulphuric acid esters} Traganth and bassorin (Astragalus gummifer) {water-insoluble, quel 1 capable polysaccharide portion (bassorin) approx. 60-70%, water-soluble polysaccharide portion (traganthine), consisting of galactose and galacturonic acid} b) * Plants for the treatment of diseases of the rectum and anal area, hemorrhoids Preferably antihemorrhoidal plants: Chamomile flowers/extracts (Matricariae flos/extractum: Matricaria recutita; anti-inflammatory, spasmolytic, antibacterial1)
{contains sesquiterpenes: azulene bisabolole, enine bicycloether, flavonoids, mucilage} Tannin - Plants: Witch hazel leaves and bark (Hamamelidis folium et cortex: Hamamelis yirginiana; astringent, local hemostatic, anti-inflammatory, antibacterial) {with the main active ingredients β-, α- and γ-hamamelitannin, ellagitannin, catechins} Oak bark (Quercus cortex: Quercus robur; astringent, virostatic)
{contains catechin and gallo tannins} Bloodroot (Tormentillae rhizoma: Potentilla erecta; has an astringent effect) (contains catechin tannins, ellagic acid) Chestnut seeds (Hippocastani semen: Aesculus hippocastanum; has anti-edematous, anti-inflammatory, vein-toning effects) {contains triterpene saponins: aescin, cryptoaescin.} Arnica flowers (Arnica flos: Arnica montana; has anti-inflammatory, antiseptic properties) {contains flavonoids, sesquiterpene lactones (e.g. helenalin), essential oil ( &zgr; . B .- thymol ) } Peru balsam (Balsamum peruvianum: Myroxylum balsamum; has an antiseptic effect and promotes granulation) {contains benzyl benzoate and benzyl cinnamate} Stomach (including small and large intestine)
Homeopathic remedies. Anacardium occidentale (D6, Dl2) {for severe stomach pain, spastic constipation, choleric type} Asa foetida (D3, D4) {in the case of foul-smelling belching due to hypoacidity of the stomach, stomach pressure, flatulence, tendency to diarrhea-like stools} Capsicum annuum (D6) {for severe heartburn) Nux moschata (D4, D6) {gastrocardiac symptom complex, colicky abdominal pain} Robinia pseudacacia (D4, D6) {hyperacidity of the stomach} Strychmnos ignatii (Ignatia) (D6, D12)
{Gastrointestinal complaints as a result of psychological events} Strychnos nux vomica (Nux vomica) (D6, D12) {severe stomach pain with nausea, vomiting; spastic. constipation} Main symptom diarrhoea: Matricaria chamomilla D6 {in case of diarrhoea with colicky abdominal pain} Okoubaka aubrevillei D3 {in case of vomiting and diarrhea due to ingestion
spoiled food and when changing diet (e.g. long-distance travel); non-specific gastrointestinal complaints
after infection and/or antibiotic treatment. } Pulsatilla pratensis D6 {vomiting and diarrhea, general fat intolerance} Rheum, D4, D6 {foamy diarrhea, summer diarrhea} Veratrum album D4, D6 {Profuse diarrhea with intestinal spasms; severe nausea with recurrent vomiting, dry mouth and great thirst. Accompanying circulatory instability is typical.} (Mineral homeopathic remedies: for chronic recurrent diarrhoea: Calcium carbonicum D12; Mercurius corrosivus D6; Natrium sulphuricum D6; Sulphur D12; for acute diarrhoea: Acidum arsenicum (Arsenicum album) D12 furthermore: Argentum nitricum D12 {for psychovegetative diarrhoea}' Cuprum metalIicum D6 {Diarrhea with spasms} Ferrum metallicum D6 {Diarrhea, especially in infancy and childhood} ·· · L III · t ·» b) Liver protection group (also with a positive influence on intestinal and bile dysregulation): Milk thistle fruits (Cardui mariae, CSilybi mariaeD fructus) {the active ingredient antagonizes the damaging effects of hepatotoxic substances such as ethanol, carbon tetrachloride, thioacetamide, N-galactosamine, death cap mushroom toxins (phalloidin and Q-amanitin); explained by membrane-stabilizing effect and attack on RNA polymerase I in the liver cell nuclei.} Artichoke leaves (Cynarae folium) {liver-protective effect, liver-regeneration-promoting effect, choleretic effect, lipid-lowering} Beetroot (Beta vulgaris) {Active ingredient: (lipotropic) betaine (hepatotropic like choline and methionine); explanation of the effect: it Betaine's participation in the Transmethylation cycle of lipid metabolism in the liver and in the resynthesis of methionine assumed. Agrimony (Agrimonia eupatoria, Agrimoniae herba){Active ingredients: flavonoid compounds} Cat's paw herb (Gnaphalii C HelichrysiD herbal) {Active ingredients: the flavanone glycosides helichrysin A + B} as well as as well as the liver-protecting plants of the folk medicine of India and China: Eclipta aba (India), Wedelia calendulacea (India), Rhemania glutinosa (China), Prccorrhiza curroa (India) Phyllanthus niruri (India), Schizandra chinensis (China) {have a preferential liver-protective effect i &ngr; and promotes regeneration, e.g. T. also anti-inflammatory; Liver homeopathic remedies: Bryonia cretica D4, D6 {stabbing pain in the right upper abdomen, nausea, also bilious vomiting, existing constipation} Carduus marianus D2, D3 {in case of enlarged liver with nausea and tendency to vomit as well as consequential conditions such as portal congestion, varicosis and hemorrhoidal disease with constipation; for homeopathic routine without characteristic individual symptoms} Chelidonium majus D4, D6 , {with stabbing pain in the right upper abdomen, radiating to the shoulder; stool soft, diuretic; yellowish-colored tongue} Flower of Stone D4 D6 {Nausea, fat intolerance, flatulence, stool inconsistency; Consequences of viral or nutritional-toxic hepathopathy} Lycopodium clavatum D6, Dl2 {in case of tendency to stone formation (cholelithiasis and urolithiasis) Taraxacum officinale D3, D4
{in acute hepatitis} This active profile is shared by the liver active ingredients cumestane (Wedelia, Eclipta), lignans (Phllanthus, Schizandra) and iridoids (Rhemania) Bile protection group Greater celandine (Chelidonii herba, Chelidonium majus) {spamolytic, analgesic, contains 20 alkaloids (approx. 0.4-0.8%) with chelidonine, berberine, sanguinarine, cheleerythrine}} Bol.do leaves (Boldo folium; Peumus boldus) {Apophin alkaloids with main alkaloid boldine; choleretic spasmolytic, secretion-increasing} Fumitory herb (Fumariae herba: Fumaria officinal is) {Main alkaloid fumarin (protopine); choleretic, cholagogue, spasmolytic} Barberry root (Berberis radix, Berberis vulgaris) {with berberine, jateorhizine, palmitine as main alkaloids; has a cholagogue, spasmolytic, antibiotic effect} Javanese turmeric (Curcumae longae - Xanthorrhizae rhizoma: Curcuma longa, C. xanthorrhiza) {with the cinnamic acid derivatives curcumin and desmethoxycurcumin; contains essential oil with e.g. the sesquiterpenes cucurmen, xanthorrhizol, turmerone: has a choleretic and cholagogue effect} Dandelion root with herb (Taraxaci radix c. herba: Taraxacum officinale) {contains sesquiterpene bitter substances, triterpenes (taraxasterol) and sterols (sitosterol, stigmasterol; has a choleretic, diuretic, secretion-increasing effect.}- preferably cholagogue or choleretic: Artichoke leaves (Cynarae folium: C. scolymus) {with 0.02-0.03% cynarin (dicaffeoylquinic acid); sesquiterpene lactone bitter substances (cynaropicrin)} Wormwood (Absinthii herba: Artemisia absinthium) {contains the bitter substances asinthin, artabsin and the essential oils (+)-thujone and thujyl alcohol, little chamazulene} Gentian root (Gentianae radix, &zgr;. B. Gentiana lutea) {contains the secoiridoid bitter substances gentiopicrin, amarogentin (with the highest bitter value 1: 58 000 000} Peppermint leaves (Menthae folium: Mentha piperita) {contains the monoterpenes menthol, menthyloacetate, menthone, menthofuran and others} Radish root (Raphani radix: Raphanus sativus) {contains glucosinolates such as glucobrasicin and sinapine, which produce mustard oils (e.g. allyl and butyl mustard oil) during steam distillation.}