DE29724348U1 - Keratous comedone remover - Google Patents

Description

The present invention relates to a keratous comedone remover which is excellent in removing keratous comedones formed in the pores of the skin, and a method for removing keratous comedones from the skin using this keratous comedone remover.

Discussion of the state of the art:

Having clearly visible pores in the skin is a serious skin problem especially for women and is mainly caused by keratotic comedones that are formed in the pores of the skin. Keratotic comedones are dead epidermal cells that are keratinized along with sebaceous matter and dirt and clog the pores of the skin. If proper treatment is not provided, not only clearly visible pores but also various skin problems are the result. Accordingly, removal of keratotic comedones is recommended from the point of view of the health and beauty of the skin.

However, ordinary facial detergents and makeup removers cannot adequately remove keratotic comedones.

Pack preparations that are applied to the skin and after

Drying peeling agents, which generally contain an anionic or non-ionic polymer such as polyvinyl alcohol and polyvinylpyrrolidone as the main component of a film-forming agent, are still not sufficiently effective for removing dirt from the skin pores and especially for removing keratotic comedones.

Therefore, there remains a need for a keratotic comedone remover that can effectively remove keratotic comedones formed in the pores of the skin and a method for removing keratotic comedones from the skin using such comedone removers.

SUMMARY OF THE INVENTION

Accordingly, it is an object of the present invention to provide novel keratotic comedone removers that effectively remove keratotic comedones from the skin.

It is another object of the present invention to provide a method for removing keratotic comedones from the skin using such keratotic comedone removers .

These and other objects which will become apparent from the detailed description which follows have been accomplished by the inventors' discovery that a keratotic comedone remover comprising a synthetic polymer having a salt-forming group is effective in removing keratotic comedones and dirt from the pores of the skin.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The salt-forming group of the polymer useful in the present invention is not particularly limited as long as it can form a salt in the presence of an acid or a base, and anionic, cationic and amphoteric groups are suitable. Examples of the salt-forming group are carboxyl group, sulfonic acid group, sulfuric acid residue group (-OSO ₃ H), phosphoric acid residue group (-OPO ₃ H ₂ ), nitric acid residue group (-NO ₂ ), amino group,

ammonium group and the like. Two or more of these groups may be present in a compound.

The polymer compound useful in the present invention is preferably water-soluble from the viewpoint of good appearance, but it is not necessarily water-soluble for the purpose of achieving the effects of this invention. The compounds which are not water-soluble may take the form of a dispersion and/or emulsion.

Examples of the polymers useful in the present invention include hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, which are mucopolysaccharides; alginic acid, sodium alginate, ammonium alginate, sodium carboxymethyl cellulose and carboxymethyl amylose, which are hemicelluloses. These are naturally-sourced or semi-synthesized polymers. In this invention, synthesized polymers are more preferable. Examples of the synthesized polymers include (A) polymers of one or more monomers listed in (1) to (3) below, (B) copolymers of the monomers listed in (1) to (3) and another monomer having no salt-forming group, such as vinyl esters of aliphatic carboxylic acids, e.g., vinyl acetate; (Meth)acrylic acid esters, e.g. methyl methacrylate, alkyl vinyl ethers, e.g. methyl vinyl ether, cyclic N-vinylamides, such as N-vinylpyrrolidone, styrene and alkyl-substituted styrene, and (C) mixtures of the above-mentioned polymers.

(1) Anionic monomers:

Acrylic acid (AA), methacrylic acid (MA), maleic acid, itaconic acid and the like, which are unsaturated carboxylic acid monomers or their anhydrides or their salts;

Styrenesulfonic acid, 2-acrylamide-2-methylpropanesulfonic acid (AMPS) and the like, which are unsaturated sulfonic acid monomers or their salts;

Vinylphosphonic acid, acid phosphooxyethyl (meth)acrylate and the like, which are unsaturated phosphoric monomers.

(2) Cationic monomers

Dimethylaminoethyl acrylate (DMAEA), dimethylaminoethyl methacrylate (DMAEMA), dimethylaminopropylacrylamide (DMAPAAm)> dimethylaminopropylmethacrylamide (DMAPMAAm) and the like, which are (meth)acrylamides or (meth)acrylic acid esters having a dialkylamino group;

Dimethylaminostyrene (DMASt), dimethylaminomethylstyrene (DMAMSt) and the like, which are styrenes having a dialkylamino group;

4-vinylpyridine, 2-vinylpyridine and the like, which are vinylpyridines;

quaternized products of these with a known quaternizing agent such as alkyl halide, benzyl halide, alkyl or aryl sulfonic acid or dialkyl sulfate.

(3) Amphoteric monomers

N-(3-Sulfopropyl)-N-acryloyloxyethyl-^N-dimethylammonium betaine, N-(3-sulfopropyl)-N-methacroylamidpropyl-N,N-dimethylammonium betaine, N-(3-carboxymethyl)-N-methacroylamidpropyl-N^ -dimethylamitionium betaine, N-carboxymethyl-N-methacroyloxyethyl-N^-dimethylammonium betaine.

When the salt-forming group of these polymers is not ionized, it is preferred to neutralize them with known acids such as hydrochloric acid or sulfuric acid, which are inorganic acids; acetic acid, propionic acid, lactic acid,

succinic acid, glycolic acid, which are organic acids, or with known bases such as triethylamine, trimethylamine, which are tertiary amines, ammonia; or sodium hydroxide.

Among the polymer compounds mentioned, preferred ones in view of the mildness for the skin and the high effectiveness for removing keratotic comedones are polymers of one or more cationic monomers, copolymers between one of these polymers and an amphoteric monomer or a monomer without salt-forming groups and mixtures of these polymers.

Preferred examples of these cationic monomers include dimethylaminoethyl acrylate (DMAEA), dimethylaminoethyl methacrylate (DMAEMA), dimethylaminopropylacrylamide (DMAPAAm), dimethylaminopropylmethacrylamide (DMAPMAAm) and the like, which are (meth)acrylic esters or (meth)acrylamides having a dialkylamino group; and quaternary compounds thereof quaternized with a known quaternizing agent such as alkyl halide, benzyl halide, alkyl or aryl sulfonic acid or dialkyl sulfate. Among these, particularly preferred are dimethylaminoethyl methacrylate (DMAEMA) and its quaternized products; quaternized products of dimethylaminopropylmethacrylamide (DMAPMAAm); polymers of one or more of these monomers; copolymers between one or more of these monomers and the above-mentioned monomers; and mixtures thereof.

The molecular weight (weight average) of these polymers is preferably in the range of 10,000 to 1,500,000, and more preferably 100,000 to 1,000,000. Molecular weights of less than 10,000 result in insufficient film strength and films that tear easily when peeled off. Polymers with a molecular weight of more than 1,500,000 are difficult to produce.

The preferred amount of the polymer to be incorporated into the keratotic comedone remover preparation according to the invention is 0.01 to 70% by weight, preferably 5 to 40% by weight, based on the total weight of the preparation.

The above-mentioned synthesized polymers are used dissolved in a solvent. The polymer useful in this invention

Solvent is volatile and is not particularly limited as long as it can stably dissolve the polymers and is safe for the skin. Examples of such solvents include water, ethanol, isopropyl alcohol (IPA) and the like. They are used singly or in combination. The amount of the solvent is modified depending on the properties of the polymer compounds, the optional ingredients and forms of the preparation, and is usually 30 to 99.99% by weight, and preferably 60 to 95% by weight, based on the total weight of the composition.

The effectiveness of the keratotic comedone remover of this invention is enhanced when a pigment is further incorporated together with the above-mentioned polymers. The pigment is not particularly limited, and both organic and inorganic pigments can be used. Examples of inorganic pigments are zinc oxide, titanium oxide, silicon dioxide, aluminum oxide, barium sulfate, zirconium oxide, calcium carbonate, calcium silicate, ceramics, hydroxyapatite, boron nitride, sericite, mica, talc, kaolin, montmorillonite, hectorite, saponite, black iron oxide, yellow iron oxide, red iron oxide, Eerliner Elau, ultramarine, carbon black, pearlescent pigments, etc. Examples of organic pigments are silk powder, Ce1Iu1 ωsepu1 ver, poly(meth)acrylic acid ester resins, polyamide resins, polyolefin resins, polyimide resins, polyurethane resins, polyester resins, polyether resins, polyvinyl chloride resins, urea resins, polyformaldehyde resins, polycarbonate resins, polyvinyl acetate resins, polyvinylidene chloride resins, polyacrylonitrile resins, polysulfone resins, polystyrene resins, polyurea resins, silicone resins, Melamine resins, polytetrafluoroethylene resins, scratch pigments and azo dyes.

The particle size of the pigments is 0.001 to 1000 micrometers, and preferably 0.01 to 500 micrometers. A particle size of less than 0.001 micrometer is not preferred because good dispersibility cannot be obtained. A particle size of more than 1000 micrometers is also not preferred because of an unfavorable sensation to the skin. The mentioned pigments

may be used as a complex or as a mixture of one or more, if desired. The amount of pigment is 0.1 to 70% by weight, preferably 1 to 40% by weight, based on the total weight of the preparation.

Further, when an oil component is incorporated together with the polymers, the keratotic comedone remover of this invention can achieve excellent removal of keratotic comedones without imparting irritation to the skin. This is because the strength of the film at which it breaks when peeling can be controlled by the oil component.

The oil component useful in this invention is a glycerin derivative represented by the formula (I):

PJ-X-CH ₂ -CK-CK ₂ (D

in which one of Z represents ^L and Z ^represents R represents ^-Y- and the other represents a hydroxyl group or R represents ^-Y- , and R represents ¹ , R ^represents and ^R represents independently a hydrocarbon group whose total carbon number is in the range of 13 to 40 and in which the hydrocarbon group may or may not be substituted by a silicone residue group, X and Y independently represent an oxygen atom or a -COO- group (a carboxyl group in which the C atom is bonded to ^{R represents} , R ^represents or ^R represents independently an oxygen atom or a -COO- group (a carboxyl group in which the C atom is bonded to R represents, R represents or R represents independently an oxygen atom or a -COO- group (a carboxyl group in which the C atom is bonded to R represents, R represents independently an oxygen atom or a -COO- group) ... Alcohols such as hexadecyl alcohol and oleyl alcohol; esters such as cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, 2-octyldodecyl oleate, isopropyl myristate, glycerin triisostearate, mono-2-

ethylhexanoloylglyceryl diparamethoxycinnamate; and hydrocarbons such as dimethylpolysiloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclopentasiloxane, liquid paraffin, squalane, petrolatum and solid paraffin.

Among these oil components, glycerin derivatives of the formula (1) which are liquid at 2O ⁰ C are preferred, and in particular, tri-2-ethylhexanoylglycerin, l-isostearoyl-3-myristoylglycerin, 2-ethylhexanoyldiglyceride, l-hexyl-3-undecamethylhexasiloxypropynylglycerin are most preferred.

The amount of the oil components to be incorporated in the keratotic comedone remover of this invention is 0.5 to 30% by weight, preferably 1 to 15% by weight, based on the total weight of the composition.

The keratotic comedone remover preparation of this invention may further contain optional ingredients generally incorporated in cosmetic preparations. Examples of such optional ingredients include ethylene glycol, diethylene glycol, triethylene glycol and higher polyethylene glycols; propylene glycol, dipropylene glycol and higher polypropylene glycols; 1,3-butylene glycol, 1,4-butylene glycol and other butylene glycols; glycerin, diglycerin and higher polyglycerols; sugar alcohols such as sorbitol, mannitol, xylitol and maltitol; ethylene oxides (hereinafter referred to as EO) such as glycerols; addition products of propylene oxide (hereinafter referred to as PO); EO or P0 adducts of sugar alcohols; monosaccharides such as galactose, glucose and fructose and their EO or P0 adducts; Polysaccharides such as maltose and lactose and their EO or PO adducts (polyols); surfactants such as POE alkyl ethers (POE is polyoxyethylene), branched POE alkyl ethers, POE sorbitan esters, POE glycerol fatty acid esters, hydrogenated POE castor oils, sorbitan esters, glycerol fatty acid esters and polyglycerol fatty acid esters; medicinal substances such as vitamins, anti-inflammatory agents, activators, UV absorbers and

·

the like; water-swellable clay minerals such as montmorillonite, saponite and hectorite; polysaccharides such as carrageenan, xanthan gum, sodium alginate, pullulan, methylcellulose, carboxymethylcellulose, hydroxyethylcellulose and hydroxypropylcellulose; synthetic polymers such as carboxyvinyl polymers, polyvinylpyrrolidones and polyvinyl alcohols. They are incorporated into the preparation of the present invention in such amounts that they do not hinder the effects of the invention. In particular, when polyols are used, they are preferably incorporated at 0.01 to 50% by weight based on the total preparation.

The keratotic comedone remover according to this invention may take the form of a poultice using a cotton cloth, rayon cloth, tetron cloth, nylon cloth, either woven or non-woven, or using a plastic film sheet, in addition to packing preparations.

The keratotic comedone remover of this invention can be prepared by conventional methods for preparing ordinary packs and poultices.

The manner of removing keratous comedones by using the keratous comedone remover of the invention is the same as the manner of using ordinary packs and poultices. That is, when a pack preparation is used, it is first applied to the part of the skin that has keratous comedones, especially likely to be on the nose, chin and forehead, and after it is dried, it is peeled off.

Since the keratotic comedone remover of this invention effectively removes keratotic comedones, the obvious visibility of skin pores is alleviated, the skin pores are kept clean, and healthy skin can be maintained. Furthermore, the remover of this invention does not injure the skin.

10

Other features of the invention will become apparent in the course of the following descriptions of exemplary embodiments which are given for illustration of the invention and are not intended to be limiting thereof.

EXAMPLES

Unless otherwise stated, all amounts in the examples are expressed as % by weight based on the total weight of the composition.

Example 1:

Keratotic comedone removers were prepared according to the pack preparation method mentioned below using the polymers listed in Table 1. A test group washed their face and used the preparation at an application rate of 0.1 ml/cm ² on their face. The conditions of use were a temperature of 25 ⁰ C, 50% humidity for 3 0 minutes. When 3 0 minutes had elapsed, the pack was peeled off. The ratio of removal of keratotic comedones was calculated according to the following equation for evaluation.

Removal ratio of keratous comedones Number of keratous comedones attached to 1 cm ² packing

Number of keratotic comedones that existed in 1 cm ² of nasal wing skin

The results are also shown in Table 1. Evaluation:

A: over 20% removal ratio of keratotic

Comedones
B: 5 to 20% removal ratio of keratotic

Comedones
C: less than 5% removal ratio of

11

keratotic comedones

Manufacturing: Polymer Glycerin HCO60 (hydrogenated polyoxyethylene castor oil 60EO adduct) Ethanol Perfume Antiseptic Purified water Total

15 until 20 ,5 to Weight % 5 ,0 1 5 0 ,5 suitable Crowd 67 72 _r5 100

Table 1

Polymers Ionic Poly-2-acrylamide-2-methylpropanesulfonate (AMPS)
(MG: 500000) Anionic/
Cationic Evaluation
(Distance
from
keratous
comedones ) Not
Ionic Polymethacryloyloxymethyl succinate (MW: 200000) Polymer of Na*styrenesulfonic acid (NaSS) (MW: 100000) Anionic A Polymer of methacrylic acid (MAA) (MW: 200000) Anionic A Copolymer of NaSS/MAA (1:1) (MW: 400000) Anionic A Polymethacryloyloxyethyltrimethylanunonium chloride (QDM)
(MG: 400000) Anionic A Polymethacryloyloxyethyltriethylammonium diethylsulfate
(DEAMA-DES) (MG: 300000) Anionic A Polymethacrylamidepropyltrimethylammonium chloride (MAPTAC)/
Polyacrylamidepropyltrimethylammonium chloride (DMAPAAm-Q)-
Copolymer (8:2 molar ratio) (MW: 3 00000) Cationic A Cationic A Polyvinyl alcohol (PVA) (MG: 1000 00) Cationic A Polyethylene oxide (PEO) (MW: 1000000) Pullulan (MG: 70000) _ C Hydroxyethylcellulose (HEC) (MG: 100000) — C Polyvinylpyrrolidone (PVP) (MW: 60 0000) — C — C - C

••«H*

11 l· ν TM * t H 1

13 Example 2:

Keratotic comedone removers were prepared using the polymers listed in Table 2, and the removal ratio of keratotic comedones and the pain of peeling were examined.

The polymers were prepared individually in an aqueous 20-30 wt% _T Igen solution and members of the test group used them in the same manner as in Example 1.

Removal ratio of keratotic comedones: =he equation in example

ension:

(Removal ratio of keratotic comedones) A: 35% or more B: 20 to 34% C: 5 to 19% D: less than 5% (pain when peeling)

mild pain: + considerable pain: ++

Table 2

Polymers Anionic/
Cationic distance from
keratotic comedones Pain during
peeling Poly-2-acrylamide-2-methylpropanesulfonate (AMPS)
(MG: 500000) Anionic B ++ Polymethacryloyloxymethyl succinate (MW: 200000) Anionic B + Polymer of Na-styrenesulfonic acid (NaSS)
(MG: 100000) Anionic A ++ Methacrylic acid (MAA) polymer (MW: 200000) Anionic B ++ NaSS/MAA copolymer (1:1) (MW: 400000) Anionic A ++ Polymethacryloyloxyethyltrimethylammonium
chloride (QDM) (MG: 400000) Cationic A + Polymethacrylamidepropyltrimethylanunonium chloride
(MAPTAC) (MG: 300000) Cationic A + MAPTAC/Polyacrylamidepropyltrimethylammoniumuni-
Chloride (DMAPAAm-Q) copolymer (8:2)
(MG: 300000) Cationic A + MAPTAC (MG: 300000)/QDM (MG: 400000) mixture Cationic A -\-

15 Example 3:

Keratotic comedone removers with the formulations shown in Table 3 were prepared according to the conventional method, and the keratotic comedone removal performance was evaluated. The results are shown in Table 4.

Evaluation procedure:

Test members washed their faces and applied keratotic comedone remover to their cheeks (0.1 ml/cm ² ). The applications were allowed to stand at 25 ⁰ C, humidity 50%, for 30 minutes, and then the packing film was peeled off. The number of members who used invention product A on their left cheek and invention product B on their right cheek was the same as the number of members who used invention product B on their left cheek and invention product A on their right cheek.

The panelists evaluated the removers by answering "Invention product A removed better", "Invention product A and invention product B were almost the same in terms of removal performance" or "Invention product B removed better", and their percentages were obtained.

Table 3

Components
(Weight %) Invention Products A 2 3 Invention Products B 2 suitable amount Poly-2-acrylamide-2-methylpropanesulfonate
(AMPS) (MG: 500000) 1 25 - 1 - rest Polymethacryloyloxyethyltrimethylammonium
chloride (QDM) (MG: 400000) 25 - 25 25 25 Silicon dioxide (average particle size =
5 micrometers) - - 10 - - Zinc oxide (average particle size: 0.04
micrometer) - - - - - Sericite (long axis: 5 to 10 micrometers) 3 10 — - - HCO4 0 (hydrogenated polyoxyethylene castor oil
40EO adduct) _ 3 3 — 3 Glycerine 3 5 5 3 5 Perfume 5 0.5 0.5 5 0.5 antiseptic 0.5 0.5 Purified water

• J ♦

Table 4

Left (Right) - Right (Left) Invention Product A
removed better Invention products
A and B are
similar Invention Product B
removed better Invention - Invention
product Al product Bl 90 10 0 Invention - Invention
product A2 product Bl 90 10 0 Invention - Invention
product A3 product B2 80 20 0

• ·♦ ·· • 4 ·♦ *· *« ·· »· ·· ·*

18 Example 4:

Keratotic comedone removers formulated as shown in Table 5 were prepared in the usual manner.

The obtained keratotic comedone removers were used by a test group consisting of 20 members in the same manner as described in Example 1. The pain during peeling was evaluated by the following criteria. The results are shown in Table 5. As for the removal of keratotic comedones, all the preparations removed well.

Evaluation:

O: No pain felt X: Pain felt

Table 5

Components Invention Products C 2 3 Invention Products D 2 suitable amount 0 0 0 X X • «
• (Weight %) 1 25 - 1 - rest * ♦
• *
··· * Poly-2-acrylamide-2-methylpropanesulfonate
(AMPS) (MG: 500000) 25 - 25 25 25 *l ·
· Polymethacryloyloxyethyltriammonium
chloride (QDM) (MG: 400000) - — 3 - - · · Tri-2-ethylhexanoylglycerol 3 3 — - - » · 2-Ethylhexanoyldiglyceride — 5 5 - 5 Glycerine 5 1 1 5 1 HCO40 (hydrogenated polyoxyethylene castor oil
40EO adduct) 1 1 1 1 Squalane 1 5 5 — 5 Ethanol 5 0.5 0.5 5 0.5 Perfume 0.5 0.5 antiseptic Purified water Pain when peeled

20 Example 5:

Keratotic comedone removers formulated as shown in Table 6 were prepared according to the conventional procedure.

The obtained keratotic comedone removers effectively removed keratotic comedones without causing pain during peeling.

Table 6

Components
(Weight %) Invention Products E 4 5 6 7 8th 9 10 11 12 13 suitable amount Polymethacrylamidepropyltrimethylammonium
chloride (MAPTAC) (MG: 500000) 10 10 rest Polymethacryloyloxyethyltrimethylammonium
chloride (QDM) (MG: 400000) 10 10 Na · Styrenesulfonic acid/methacrylic acid copolymer
(MG: 400000) 25 Poly-2-acrylamide-2-niethylpropanesulfonate
(AMPS) (MG: 500000) 30 20 Polymethacrylamidepropyltrimethylammonium
chloride (MAPTAC) (MG: 50000) 35 20 20 Polymethacryloyloxyethyltrimethylammonium
chloride (QDM) (MG: 70000) 30 20 20 20 Polyvinyl alcohol (MG: 30000) 5 5 PEG 200 (polyethylene glycol 200) 5 5 5 5 3 3 3 3 3 3 HCO 40 (hydrogenated polyoxyethylene castor oil
40 EO adduct) 1 1 1 1 1 1 1 1 1 1 Squalane 1 1 1 1 1 1 1 1 1 1 2-Ethylhexanoyldiglyceride 3 2 3 3 3 3 Tri-2-ethylhexanoylglycerol 1 2 l-Hexyl-3-undecamethylhexasiloxanepropynyl-
glycerine 3 2 2 2 l-Isostearoyl-3-myristoylglycerol 2 3 3 3 Silicon dioxide 10 Sericite 10 Perfume 0,
5 0,
5 0.5 0,
5 0.5 0.5 0.5 0.5 0.5 0.5 antiseptic Water

22

Example 6:

A keratotic comedone remover with the following formulation was prepared.

Polymethacryloyloxytrimethylammonium

Chloride (QDM) (MW: 400,000) 27.0% by weight

Sorbitol 3.0

Sericite . 3.0

ethanol 5.0

Antiseptic appropriate amount

Water Rest

Example 7:

A keratotic comedone remover with the following formulation was prepared.

Polymethacryloyloxytrimethylammonium

Chloride (QDM) (MW: 250,000) 27.0% by weight

hydrogenated polyoxyethylene castor oil

(E.O. 20) 2.0

Squalane 0.5

1-Isostearoy1-3-myristoylglycerol

(DGMI) 1.5

86% Glycerin 2.0

Propylene glycol 1.0

Sericite 3.0

ethanol 5.0

Antiseptic appropriate amount

Water Rest

Example 8:

A keratotic comedone remover with the following formulation was prepared.

23

Polymethacryloyloxytrimethylammonium

chloride (QDM) (MG: 200000)

Polymethacrylamidepropyltrimethyl

ammonium chloride (MAPTAC) (MG: 300000)

hydrogenated polyoxyethylene castor oil

15.0 wt.% 15.0

(EO40) 1.5 0.5 Squalane 2.0 2-Ethylhexanoyltriglyceride 3.0 Sorbit 7.0 kaolin 2.0 Titanium oxide 5.0 Ethanol suitable amount antiseptic rest Water

Claims (3)

1. Keratotic comedone remover in the form of a poultice with (a) a cotton cloth, rayon cloth, tetron cloth, nylon cloth, either woven or nonwoven, or a plastic film and (b) a composition comprising 1. based on the weight of the total composition, at least 5% by weight of a polymer, copolymer or a mixture thereof of one or more monomers having a salt-forming group and selected from the following group of monomers: acrylic acid, methacrylic acid, maleic acid, itaconic acid or their anhydrides or salts, 2. a pigment and 3. a surfactant. 2. Keratotic comedone remover according to claim 1, characterized in that the pigment is silicon dioxide or titanium oxide. 3. A keratotic comedone remover according to claim 1 or 2, characterized by a polymer, copolymer or mixture thereof of acrylic acid and/or methacrylic acid.