DE29623765U1 - Cosmetic and dermatological light protection formulations containing triazine derivatives and glycerol mono- or dicarboxylic acid monoesters - Google Patents

Description

Beiersdorf Aktiengesellschaft Hamburg

Description

Cosmetic and dermatological sunscreen formulations containing Triazine derivatives and glycerol mono- or dicarboxylic acid monoesters

The present invention relates to cosmetic and dermatological sunscreen preparations, in particular skin-care cosmetic and dermatological sunscreen preparations.

The damaging effect of the ultraviolet part of solar radiation on the skin is well known. While rays with a wavelength less than 290 nm (the so-called UVC range) are absorbed by the ozone layer in the Earth's atmosphere, rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema, a simple sunburn or even more or less severe burns.

The narrower range around 308 nm is given as the maximum of the erythema effectiveness of sunlight.

Numerous compounds are known to protect against UVB radiation, most of which are derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, salicylic acid, benzophenone and 2-phenylbenzimidazole.

It is also important to have filter substances available for the range between about 320 nm and about 400 nm, the so-called UVA range, as its rays can also cause damage. It has been proven that UVA radiation causes damage to the elastic and collagen fibers of the connective tissue, which causes premature aging of the skin, and that it is the cause of numerous phototoxic and photic

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toallergic reactions. The damaging effect of UVB radiation can be increased by UVA radiation.

However, UV radiation can also lead to photochemical reactions, whereby the photochemical reaction products then interfere with the skin metabolism.

Such photochemical reaction products are primarily radical compounds, e.g. hydroxyl radicals. Undefined radical photoproducts that form in the skin itself can also exhibit uncontrolled subsequent reactions due to their high reactivity. But singlet oxygen, a non-radical excited state of the oxygen molecule, can also occur with UV radiation, as can short-lived epoxides and many others. Singlet oxygen, for example, is characterized by increased reactivity compared to the normally present triplet oxygen (radical ground state). However, excited, reactive (radical) triplet states of the oxygen molecule also exist.

Furthermore, UV radiation is considered ionizing radiation. There is therefore a risk that ionic species may also be formed during UV exposure, which in turn can have an oxidative effect on biochemical processes.

A beneficial UVB filter is 4.4 ^l ,4"-(1 _l 3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester), synonym: 2,4,6-tris-[anilino-(p-carbo-2'-ethyl-1 '-hexyloxy)]-1,3,5-triazine.

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This UVB filter substance is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150 and is characterized by good UV absorption properties.

The main disadvantage of this UVB filter is its poor solubility in lipids. Known solvents for this UVB filter can dissolve a maximum of about 15% by weight of this filter, corresponding to about 1-1.5% by weight of dissolved, and therefore active, UV filter substance.

However, it was surprising and not foreseeable for the expert that sunscreen active ingredient combinations from

(a) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester) and

(b) one or more surface-active substances selected from the group of glycerol mono- or dicarboxylic acid monoesters of the general formula

_{CH2OR3 ​}

CH-O-H

_CH2 -OH

or.

_CH2OH

CH-OR ₃

_CH2 -OH

where R ₃ represents a branched or unbranched acyl residue having 6 - 24 carbon atoms,
remedy the disadvantages of the state of the art

The invention also particularly relates to the use of one or more surface-active substances selected from the group of glycerol mono- or dicarboxylic acid monoesters of the general formula

CH ₂ -OR ₃ CH-OH CH ₂ OH

or.

CH ₂ -OH CH-OR ₃ CH ₂ -OH

where R ₃ represents a branched or unbranched acyl radical having 6 - 24 carbon atoms, as a solvent, solubilizer or solubilizer for 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester), in particular for use in light stabilizers.

According to the invention, it is possible to double the amounts of 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester) used in cosmetic or dermatological preparations compared to the prior art.

It was surprising that by adding surface-active glycerol mono- or dicarboxylic acid monoesters used according to the invention, a stabilization of solutions of 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester) is brought about, since the latter substance not only has poor solubility, but also easily crystallizes out of its solution. Therefore, also according to the invention is a process for stabilizing solutions of 4,4',4"-(1,S,S-triazine^Ae-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester), characterized in that an effective content of glycerol mono- or dicarboxylic acid monoesters used according to the invention is added to such solutions.

R ₃ preferably represents a myristyl residue, palmityl residue, stearyl residue or eicosyl residue.

Particularly advantageous in the sense of the present invention has been found to be
Of the surfactants listed in point (b), glyceryl stearate was highlighted,
which is sold in the trade, for example, under the product name
Tegin® M is available from Th.Goldschmidt KG.

The total amount of 4,4 ^l ,4"-(1,3,5-triazine-2 _l, 4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester) in the finished cosmetic or dermatological preparations is advantageously selected from the range of 0.1 - 10.0 wt.%, preferably 0.5 - 6.0 wt.%, based on the total weight of the preparations.

The total amount of one or more surface-active glycerol mono- or dicarboxylic acid monoesters used according to the invention in the finished cosmetic or dermatological preparations is advantageously selected from the range of 0.1-25.0% by weight, preferably 0.5-15.0% by weight, based on the total weight of the preparations.

It is advantageous to use weight ratios of 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-trisbenzoic acid tris(2-ethylhexyl ester) and one or more of the compounds according to the invention.

used glycerol mono- or dicarboxylic acid monoesters should be selected from the range of 1:10 to 10:1, preferably 1:4 to 4:1.

Cosmetic and dermatological preparations according to the invention advantageously also contain inorganic pigments based on metal oxides and/or other metal compounds which are sparingly soluble or insoluble in water, in particular the oxides of titanium (TiO ₂ ), zinc (ZnO), iron (eg Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon (SiO ₂ ), manganese (eg MnO), aluminum (Al ₂ O ₃ ), cerium (eg Ce ₂ Oa), mixed oxides of the corresponding metals and mixtures of such oxides. Pigments based on TiO ₂ are particularly preferred.

It is particularly advantageous in the sense of the present invention, although not essential, if the inorganic pigments are in hydrophobic form, i.e. that their surface is treated to be water-repellent. This surface treatment can consist of providing the pigments with a thin hydrophobic layer using methods known per se.

One such method consists, for example, in the hydrophobic surface layer being treated after a reaction according to

&eegr; TiO ₂ + m (RO) ₃ Si-R'-> ? TiO ₂ (surface)

is produced, η and m are stoichiometric parameters to be used as desired, R and R' are the desired organic radicals. For example, hydrophobized pigments prepared analogously to DE-OS 33 14 742 are advantageous.

Advantageous TiO ₂ pigments are available, for example, under the trade names MT 100 T from TAYCA, M 160 from Kemira and T 805 from Degussa.

The cosmetic and/or dermatological sun protection formulations according to the invention can be composed as usual and can be used for cosmetic and/or dermatological sun protection, for the treatment, care and cleaning of the skin and/or hair and as a make-up product in decorative cosmetics.

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For use, the cosmetic and dermatological preparations according to the invention are applied to the skin and/or hair in sufficient quantities in the manner customary for cosmetics.

Particularly preferred are cosmetic and dermatological preparations which are in the form of a sunscreen. These can advantageously additionally contain at least one further UVA filter and/or at least one further UVB filter and/or at least one inorganic pigment, preferably an inorganic micropigment.

The cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliaries as are usually used in such preparations, e.g. preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments which have a coloring effect, thickeners, moisturizing and/or humectant substances, fats, oils, waxes or other usual components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

An additional content of antioxidants is generally preferred. According to the invention, all antioxidants suitable or customary for cosmetic and/or dermatological applications can be used as favorable antioxidants.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, ß-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl-, N-acetyl-, methyl-, ethyl-, Propyl, amyl, butyl and lauryl, palmitoyl, oleyl, &ggr;-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyfthiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very

low tolerated doses (e.g. pmol to μΓηγ/kg), furthermore (metal) chelators (e.g. a-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), a-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, furfurylidene sorbitol and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and Derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin resin, rutinic acid and derivatives thereof, ot-glycosylrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiatric acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (e.g. ZnO, ZnSO ₄ ), selenium and derivatives thereof (e.g. selenomethionine), stilbenes and derivatives thereof (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active ingredients.

The amount of the aforementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30 wt.%, particularly preferably 0.05-20 wt.%, in particular 1-10 wt.%, based on the total weight of the preparation.

If vitamin E and/or its derivatives represent the antioxidant(s), it is advantageous to choose their respective concentrations from the range of 0.001 - 10% by weight, based on the total weight of the formulation.

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives represent the antioxidant(s), it is advantageous to choose their respective concentrations from the range of 0.001 - 10 wt.%, based on the total weight of the formulation.

The lipid phase can advantageously be chosen from the following group of substances:
Mineral oils, mineral waxes

Oils such as triglycerides of capric or caprylic acid, but preferably castor oil;

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6 6 0000 ^&bgr;

Fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with low-carbon alcohols, e.g. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low-carbon alkanoic acids or with fatty acids;

alkyl benzoates;

Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixtures thereof.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the sense of the present invention is advantageously selected from the group of esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids with a chain length of 3 to 30 C atoms and saturated and/or unsaturated, branched and/or unbranched alcohols with a chain length of 3 to 30 C atoms, from the group of esters of aromatic carboxylic acids and saturated and/or unsaturated, branched and/or unbranched alcohols with a chain length of 3 to 30 C atoms. Such ester oils can then advantageously be selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. jojoba oil.

Furthermore, the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, silicone oils, diaryl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, namely triglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms. The fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semi-synthetic and natural oils, e.g. olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Any mixtures of such oil and wax components can also be used advantageously in the sense of the present invention. It can also be advantageous

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to use waxes, such as cetyl palmitate, as the sole lipid component of the oil phase.

The oil phase is advantageously selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, Ci2-is-alkyl benzoate, caprylic-capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C12-is-alkyl benzoate and 2-ethylhexyl isostearate, mixtures of _C12 -is-alkyl benzoate and isotridecyl isononanoate and mixtures of C13-is-alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

Of the hydrocarbons, paraffin oil, squalane and squalene are advantageously used in the context of the present invention.

Advantageously, the oil phase can further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.

Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention. However, other silicone oils can also be used advantageously in the sense of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly(methylphenylsiloxane).

Mixtures of cyclomethicone and isotridecyl isononanoate, and of cyclomethicone and 2-ethylhexyl isostearate are also particularly advantageous.

The aqueous phase of the preparations according to the invention optionally advantageously contains

Alcohols, diols or polyols with a low carbon number, as well as their ethers, preferably ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore alcohols with a low carbon number, e.g. ethanol, isopropanol, 1,2-propanediol, glycerin and in particular one or more thickeners, which

ches or which can advantageously be selected from the group silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g. hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of the so-called Carbopols, for example Carbopols of the types 980, 981, 1382, 2984, 5984, each individually or in combination.

The cosmetic or dermatological sun protection preparations advantageously contain inorganic pigments, in particular micropigments, e.g. in amounts of 0.1% by weight to 30% by weight, preferably in amounts of 0.5% by weight to 10% by weight, but in particular 1% by weight to 6% by weight, based on the total weight of the preparations.

It is advantageous according to the invention to use, in addition to the combinations according to the invention, oil-soluble UVA filters and/or UVB filters in the lipid phase and/or water-soluble UVA filters and/or UVB filters in the aqueous phase.

The sun protection formulations according to the invention can advantageously contain other substances which absorb UV radiation in the UVB range, the total amount of filter substances being, for example, 0.1% by weight to 30% by weight, preferably 0.5% to 10% by weight, in particular 1% to 6% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations which protect the skin from the entire range of ultraviolet radiation. They can also serve as sunscreens.

The other UVB filters can be oil-soluble or water-soluble. Advantageous oil-soluble UVB filter substances are, for example:

- 3-benzylidenecamphor derivatives, preferably 3-(4-methylbenzylidene)camphor, 3-benzylidenecamphor;

- 4-aminobenzoic acid derivatives, preferably 4-(dimethylamino)benzoic acid (2-ethylhexyl) ester, 4-(dimethylamino)benzoic acid amyl ester;

- Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;

- Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;

- Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di(2-ethylhexyl) ester;

Advantageous water-soluble UVB filter substances include:

- Salts of 2-phenylbenzimidazole-5-sulfonic acid such as its sodium, potassium or triethanolammonium salt, as well as the sulfonic acid itself;

- Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and their salts;

- Sulfonic acid derivatives of 3-benzylidene camphor, such as 4-(2-oxo-3-bornylidenemethyl)benzenesulfonic acid, 2-methyl-5-(2-oxo-3-bornylidenemethyl)sulfonic acid and their salts.

The list of other UVB filters mentioned, which can be used in combination with the active ingredient combinations according to the invention, is of course not intended to be limiting.

It can also be advantageous to combine the combinations according to the invention with other UVA filters which have previously been conventionally contained in cosmetic preparations. These substances are preferably derivatives of dibenzoylmethane, in particular 1-(4'-tert-butylphenyl)-3-(4 ^l -methoxyphenyl)propane-1,3-dione and 1-phenyl-3-(4'-isopropylphenyl)propane-1,3-dione. These combinations or preparations which contain these combinations are also the subject of the invention. The amounts used for the UVB combination can be used.

Furthermore, it is advantageous to combine the active ingredient combinations according to the invention with other UVA and/or UVB filters.

It is also particularly advantageous to combine the active ingredient combinations according to the invention with salicylic acid derivatives, some representatives of which are known which can also absorb UV radiation. Common UV filters include

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(4-isopropylbenzyl salicylate), (2-ethylhexyl salicylate, octyl salicylate),

(Homomenthyl salicylate).

The invention also relates to a process for producing the cosmetic and/or dermatological sunscreen preparations according to the invention, which is characterized in that the 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris(2-ethylhexyl ester) is suspended in a manner known per se in one or more surface-active glucose derivatives used according to the invention or an oil phase containing surface-active glucose derivatives used according to the invention with uniform stirring and optionally with heating and, if desired, homogenized, optionally combined with further lipid components and optionally with one or more emulsifiers, then the oil phase is mixed with the aqueous phase, into which a thickener has been incorporated if desired and which preferably has approximately the same temperature as the oil phase, homogenized if desired and allowed to cool to room temperature. After cooling to room temperature, in particular if volatile components are still to be incorporated, further stirring can be carried out. Homogenization takes place.

The following examples are intended to illustrate the present invention without limiting it. Unless otherwise stated, all amounts, proportions and percentages are based on the weight and the total amount or the total weight of the preparations.

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example 1

% by weight Glyceryl stearate SE 3.50 Sorbitan monostearate 1.80 Glycerine 3.00 Cetearyl alcohol 0.50 Octyldodecanol 7.00 Caprylyl ether 8.00 UvinulT150 3.00 Cetearyl isononanoate 6.00 Carbomer 0.20 Preservatives qs. Perfume q.s. Water, demineralized. to 100.00

Example 2

% by weight Glyceryl stearate 2.50 Sorbitan monostearate 3.50 Glycerine 3.00 Cetearyl alcohol 1.50 Sodium hydroxide (45%) 0.13 Octyldodecanol 7.00 Capric/Caprylic Triglyceride 5.00 Cetearyl isononanoate 6.00 UvinulT150 5.00 Carbomer 0.20 Preservatives q.s. Perfume q.s. Water, demineralized. up to 100,00 Example 3 % by weight Sorbitan monostearate 3.50 Butylene glycol 5.00 Cetearyl alcohol 3.00 Xanthan Gum 0.35 C12-C15 Alkyl Benzoates 10.0 UvinulT150 4.00 Cetearyl isononanoate 6.00 Preservatives q.s. Perfume q.s. Water, demineralized. up to 100,00

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C* ·

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Example 4

% by weight Glyceryl stearate SE 3.50 Sorbitan monostearate 1.80 Glycerine 3.00 Cetearyl alcohol 0.50 Octyldodecanol 7.00 Caprylyl ether 8.00 Uvinul T150 3.00 Parsol 1789 2.00 Eusolex 6300 1.00 Titanium dioxide 2.00 Cetearyl isononanoate 6.00 Carbomer 0.20 Preservatives q.s. Perfume q.s. Water, demineralized. to 100.00

Example 5

% by weight Glyceryl stearate 2.50 Sorbitan monostearate 3.50 Glycerine 3.00 Cetearyl alcohol 1.50 Sodium hydroxide (45%) 0.13 Octyldodecanol 7.00 Capric/Caprylic Triglyceride 5.00 Cetearyl Isononanoate 6.00 Uvinul T150 5.00 Parsol 1789 2.00 Eusolex 6300 1.00 Titanium dioxide 2.00 Carbomer 0.20 Preservatives q.s. Perfume q.s. Water, demineralized. up to 100,00

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Example 6

% by weight Sorbitan monostearate 3.50 Butylene glycol 5.00 Cetearyl alcohol 3.00 Xanthan Gum 0.35 C12-C15 Alkyl Benzoates 10.0 UvinulT150 4.00 Parsol 1789 2.00 Eusolex 6300 1.00 Titanium dioxide 2.00 Cetearyl Isononanoate 6.00 Preservatives q.s. Perfume q.s. Water, demineralized. up to 100,00

Claims (3)

1. Sunscreen active ingredient combinations from a) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris( 2- ethylhexyl ester) and b) one or more surface-active substances selected from the group of glycerol mono- or dicarboxylic acid monoesters of the general formula


where R ₃ represents a branched or unbranched acyl residue having 6-24 carbon atoms. 2. Combinations according to claim 1 or use according to claim 2, characterized in that the total amount of 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid tris( 2 -ethylhexyl ester) in the finished cosmetic or dermatological preparations is selected from the range of 0.1-10.0% by weight, preferably 0.5-6.0% by weight, in each case based on the total weight of the preparations. 3. Combinations according to claim 1 or use according to claim 2, characterized in that the total amount of glycerol mono- or dicarboxylic acid monoesters in the finished cosmetic or dermatological preparations is selected from the range of 0.1-25.0 wt.%, preferably 0.5-15.0 wt.%, in each case based on the total weight of the preparations.