DE29618094U1 - Pharmaceutical preparation - Google Patents
Pharmaceutical preparationInfo
- Publication number
- DE29618094U1 DE29618094U1 DE29618094U DE29618094U DE29618094U1 DE 29618094 U1 DE29618094 U1 DE 29618094U1 DE 29618094 U DE29618094 U DE 29618094U DE 29618094 U DE29618094 U DE 29618094U DE 29618094 U1 DE29618094 U1 DE 29618094U1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical preparation
- preparation
- preparation according
- pharmaceutical
- procaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 12
- 238000002360 preparation method Methods 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 6
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 6
- 238000011321 prophylaxis Methods 0.000 claims description 6
- 201000002311 trypanosomiasis Diseases 0.000 claims description 5
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 claims description 4
- 229960004448 pentamidine Drugs 0.000 claims description 4
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims description 3
- OKQSSSVVBOUMNZ-UHFFFAOYSA-N diminazene diaceturate Chemical compound CC(=O)NCC(O)=O.CC(=O)NCC(O)=O.C1=CC(C(=N)N)=CC=C1NN=NC1=CC=C(C(N)=N)C=C1 OKQSSSVVBOUMNZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229960005222 phenazone Drugs 0.000 claims description 3
- 229960004919 procaine Drugs 0.000 claims description 3
- 150000001409 amidines Chemical class 0.000 claims description 2
- 229920003086 cellulose ether Polymers 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 229950010741 aceturate Drugs 0.000 description 2
- XNYZHCFCZNMTFY-UHFFFAOYSA-N diminazene Chemical compound C1=CC(C(=N)N)=CC=C1N\N=N\C1=CC=C(C(N)=N)C=C1 XNYZHCFCZNMTFY-UHFFFAOYSA-N 0.000 description 2
- 229950007095 diminazene Drugs 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DVRJPUUNZTUIDQ-UHFFFAOYSA-N 2-[5-(2-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide Chemical compound NC(=N)C1=CC=CC=C1OCCCCCOC1=CC=CC=C1C(N)=N DVRJPUUNZTUIDQ-UHFFFAOYSA-N 0.000 description 1
- -1 4,4'-diamidinodiazoaminobenzene diacetamidoacetate Chemical compound 0.000 description 1
- 208000000230 African Trypanosomiasis Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000029080 human African trypanosomiasis Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000028172 protozoa infectious disease Diseases 0.000 description 1
- 201000002612 sleeping sickness Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
RICHTER, WE^p.EFRMÄNN &:GERBAULETRICHTER, WE^p.EFRMÄNN &:GERBAULET
EUROPEAN PATENT ATTORNEYS - PATENTANWÄLTE HAMBURG ■ BERLINEUROPEAN PATENT ATTORNEYS - PATENT ATTORNEYS HAMBURG ■ BERLIN
DIPL.-ING. JOACHIM RICHTER DIPL.-ING. HANNES GERBAULET DIPL.-ING. FRANZ WERDERMANNDIPL.-ING. JOACHIM RICHTER DIPL.-ING. HANNES GERBAULET DIPL.-ING. FRANZ WERDERMANN
- 1986- 1986
NEUER WALL IO KURFURSTENDAMMNEW WALL IO KURFURSTENDAMM
2O354 HAMBURG IO719 BERLIN2O354 HAMBURG IO719 BERLIN
S" (O4O> 34 OO 45/34 OO 56 S" (O3O) 8 82 74 TELEFAX (O40> 35 24 15 TELEFAX (O3O) 8 82 32S" (O4O> 34 OO 45/34 OO 56 S" (O3O) 8 82 74 FAX (O40> 35 24 15 FAX (O3O) 8 82 32
IN BÜROGEMEINSCHAFT MIT MAINITZ & PARTNERIN OFFICE SHARING WITH MAINITZ & PARTNER
RECHTSANWÄLTE · NOTARELAWYERS · NOTARIES
IHR ZEICHEN UNSER ZEICHEN HAMBURG YOUR SIGN OUR SIGN HAMBURG
YOUR FILE OUR FILEYOUR FILE OUR FILE
B 96451 III 14048 17.10.1996B 96451 III 14048 17.10.1996
Anmelder: Alain Jaques BourdichonApplicant: Alain Jaques Bourdichon
22301 Hamburg22301 Hamburg
Titel: Pharmazeutisches PräparatTitle: Pharmaceutical preparation
Die Erfindung betrifft ein pharmazeutisches Präparat zur Trypanosomiasis-Prophylaxe.The invention relates to a pharmaceutical preparation for the prophylaxis of trypanosomiasis.
In Ländern mit tropischem Klima sind Infektionskrankheiten, die durch Protozoen hervorgerufen werden, weit verbreitet, wie z. B. die sogenannte Schlafkrankheit (Trypanosomiasis), die das zentrale Nervensystem schädigt und bei Nichtbehandlung zum Tod führt. Die Krankheit betrifft Mensch und Tier gleichermaßen und muß chemotherapeutisch behandelt werden.In countries with a tropical climate, infectious diseases caused by protozoa are widespread, such as the so-called sleeping sickness (trypanosomiasis), which damages the central nervous system and leads to death if left untreated. The disease affects humans and animals alike and must be treated with chemotherapy.
Zur Chemotherapie wurden Arsenpräparate und Trypanfarbstoffe verwendet, die jedoch gesundheitsschädliche Nebenwirkungen aufweisen.Arsenic preparations and trypan dyes were used for chemotherapy, but they had harmful side effects.
Daneben werden auch andere Präparate z. B. mit Diminazen-diaceturat als Wirkstoff eingesetzt.In addition, other preparations are also used, e.g. with diminazene diaceturate as the active ingredient.
Bei den bekannten Präparaten ist es jedoch nachteilig, daß keine Prophylaxe betrieben werden kann, so daß im landwirtschaftlichen Bereich Nutzvieh, das gerade eine Infektion mit Protozoen überstanden hat, sofort wieder einer möglichen Infektion ausgesetzt ist. Auch bei sofortiger neuer Therapie wird der Organismus der Tiere so stark belastet, so daß es zu Ausfällen kommen kann oder zumindest zu einer großen Schwächung des Viehs.However, the disadvantage of the known preparations is that no prophylaxis can be carried out, so that in the agricultural sector, livestock that has just survived an infection with protozoa is immediately exposed to a possible infection again. Even if a new treatment is started immediately, the animals' organisms are so heavily burdened that failures can occur or at least the livestock becomes very weak.
Weiterhin können z. B. Urlauber, die nur in einer begrenzten Zeitspanne einem Infektionsrisiko ausgestzt sind, keine Vorsorge vor Urlaubsantritt treffen. Aber auch Personen, die ständig einem Infektionsrisiko ausgesetzt sind, können sich nicht vor einer Infektion schützen.Furthermore, holidaymakers who are only exposed to the risk of infection for a limited period of time cannot take any precautions before going on holiday. But people who are constantly exposed to the risk of infection cannot protect themselves from infection either.
Es ist daher Aufgabe der Erfindung, ein pharmazeutisches Präparat zu schaffen, das eine Trypanosomiasis-Prophylaxe erlaubt.It is therefore an object of the invention to create a pharmaceutical preparation that allows trypanosomiasis prophylaxis.
Diese Aufgabe wird durch die Merkmale des Anspruchs 1 gelöst.This object is solved by the features of claim 1.
Dazu ist erfindungsgemäß vorgesehen, ein Präparat zur Trypanosomiasis-Prophylaxe zu schaffen, das mindestens einen gegen Protozoen wirksamen Wirkstoff aus der Gruppe derFor this purpose, the invention provides for a preparation for trypanosomiasis prophylaxis, which contains at least one active agent effective against protozoa from the group of
Amidine, vorzugsweise Diminazen-di-aceturat (4,4'-Diamidinodiazoaminobenzen-diacetamidoacetat) und/oder Pentamidin (4,47-(Pentamethylendioxy)-dibenzamidin), sowie Procain oder ein Procain-Derivat enthält.Amidines, preferably diminazene di-aceturate (4,4'-diamidinodiazoaminobenzene diacetamidoacetate) and/or pentamidine (4,4 7 -(pentamethylenedioxy)-dibenzamidine), as well as procaine or a procaine derivative.
Beide vorgenannten Wirkstoffe weisen ein unterschiedliches Wirkungsspektrum auf und ergänzen sich somit in ihrer Schutzwirkung.Both of the above-mentioned active ingredients have a different spectrum of activity and thus complement each other in their protective effect.
Nach einer weiteren bevorzugten Ausführungsform ist im Präparat auch Phenazon enthalten, das im Fall einer bereits bestehenden Infektion fiebersenkend wirkt.According to a further preferred embodiment, the preparation also contains phenazone, which has a fever-reducing effect in the case of an existing infection.
Vorzugsweise wird das Präparat als Injektionslösung verwendet, so daß die einzelnen Stoffe zuerst in Lösung gebracht werden müssen. Dazu wird vorteilhafterweise eine Mischung aus Celluloseether, insbesondere Methyl-Cellulose, Glycerin und Wasser mit den Feststoffen vermengt, wobei sich einfach durch Rühren eine klare Lösung herstellen läßt.The preparation is preferably used as an injection solution, so that the individual substances must first be dissolved. To do this, a mixture of cellulose ether, in particular methyl cellulose, glycerin and water is advantageously mixed with the solids, whereby a clear solution can be produced simply by stirring.
Eine bevorzugte Ausführungsform des erfindungsgemäßen Präparats weist folgende Inhaltsstoffe auf:A preferred embodiment of the preparation according to the invention has the following ingredients:
Wirkstoffe: Diminazen-di-aceturatActive ingredients: Diminazene di-aceturate
PentamidinPentamidine
Procain oder Procain-Derivat (z.B. Hydrochlorid) PhenazonProcaine or procaine derivative (e.g. hydrochloride) Phenazone
Emulgator- Wasser-Gemisch:
GlycerinEmulsifier-water mixture:
Glycerine
Methy1-Ce1luloseMethylcellulose
Wasser (für pharmazeutische Zwecke geeignet, z. B. physiol. angeglichenes Wasser)Water (suitable for pharmaceutical purposes, e.g. physiologically adjusted water)
Das erfindungsgemäße Präparat ermöglicht die Trypanomiasis-Prophylaxe und vorteilhafterweise ist das Präparat auch gleichzeitig für die Chemotherapie einer bestehenden Protozoen-Infektion geeignet.The preparation according to the invention enables trypanomiasis prophylaxis and advantageously the preparation is also suitable for the chemotherapy of an existing protozoal infection.
Bei der Verwendung des Präparats ergibt sich ein mindestens dreimonatiger Schutz vor einer Infektion oder auch einer Wiederholungs infektion.Using the product provides at least three months of protection against infection or re-infection.
Das Präparat ist insbesondere für den Veterenär-Bereich vorgesehen. Es ist jedoch auch in der Humanmedizin einsetzbar, so daß, besonders vorteilhaft für Urlauber, eine Art Schutzimpfung durchführbar ist.The preparation is intended in particular for veterinary use. However, it can also be used in human medicine, so that a type of protective vaccination can be carried out, which is particularly advantageous for holidaymakers.
Vorteilhaft ist auch die extrem schnelle Heilung von bestehenden Infektionen innerhalb von 8 bis 12 Stunden.Another advantage is the extremely rapid healing of existing infections within 8 to 12 hours.
Weitere vorteilhafte Ausgestaltungen der Erfindung sind in den Unteransprüchen gekennzeichnet.Further advantageous embodiments of the invention are characterized in the subclaims.
Claims (8)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29618094U DE29618094U1 (en) | 1996-10-18 | 1996-10-18 | Pharmaceutical preparation |
| EP97912195A EP0936907A2 (en) | 1996-10-18 | 1997-10-17 | Pharmaceutical preparation |
| AU49482/97A AU4948297A (en) | 1996-10-18 | 1997-10-17 | Pharmaceutical preparation |
| PCT/EP1997/005724 WO1998017266A2 (en) | 1996-10-18 | 1997-10-17 | Pharmaceutical preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29618094U DE29618094U1 (en) | 1996-10-18 | 1996-10-18 | Pharmaceutical preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE29618094U1 true DE29618094U1 (en) | 1998-02-12 |
Family
ID=8030722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE29618094U Expired - Lifetime DE29618094U1 (en) | 1996-10-18 | 1996-10-18 | Pharmaceutical preparation |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0936907A2 (en) |
| AU (1) | AU4948297A (en) |
| DE (1) | DE29618094U1 (en) |
| WO (1) | WO1998017266A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853937A1 (en) * | 1998-11-24 | 2000-05-25 | Chambord Ltd | Composition useful for treating e.g. malaria, babesiosis and trypanosomiasis comprises diminazene diaceturate and procaine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4309415C2 (en) * | 1993-03-19 | 1996-11-07 | Alain Jaques Bourdichon | Pharmaceutical preparation |
| EP0643964A3 (en) * | 1993-08-18 | 1995-08-09 | Medipharma Sa | Use of local anesthetics for the manufacture of a medicament for the protection of plasma cell membranes. |
| DE19530708C2 (en) * | 1995-08-21 | 1999-01-07 | Atarost Allg Tierarzneimittelf | Pharmaceutical preparation with trypanocidal properties |
-
1996
- 1996-10-18 DE DE29618094U patent/DE29618094U1/en not_active Expired - Lifetime
-
1997
- 1997-10-17 WO PCT/EP1997/005724 patent/WO1998017266A2/en not_active Ceased
- 1997-10-17 AU AU49482/97A patent/AU4948297A/en not_active Abandoned
- 1997-10-17 EP EP97912195A patent/EP0936907A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU4948297A (en) | 1998-05-15 |
| EP0936907A2 (en) | 1999-08-25 |
| WO1998017266A3 (en) | 1998-06-25 |
| WO1998017266A2 (en) | 1998-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R207 | Utility model specification |
Effective date: 19980326 |
|
| R081 | Change of applicant/patentee |
Owner name: ATAROST ALLGEM. TIERARZNEIMITTELFABRIK DR. ULR, DE Free format text: FORMER OWNER: BOURDICHON, ALAIN-JACQUES, 22301 HAMBURG, DE Effective date: 19980625 |
|
| R150 | Utility model maintained after payment of first maintenance fee after three years |
Effective date: 20000223 |
|
| R157 | Lapse of ip right after 6 years |
Effective date: 20030501 |