[go: up one dir, main page]

DE287819T1 - 5-(phenyl oder phenoxyalkyl)-3-(2-furanyl oder 2-thienyl)-3-(1h-imidazol-1-ylmethyl)-2-methylisoxazolidine. - Google Patents

5-(phenyl oder phenoxyalkyl)-3-(2-furanyl oder 2-thienyl)-3-(1h-imidazol-1-ylmethyl)-2-methylisoxazolidine.

Info

Publication number
DE287819T1
DE287819T1 DE198888104468T DE88104468T DE287819T1 DE 287819 T1 DE287819 T1 DE 287819T1 DE 198888104468 T DE198888104468 T DE 198888104468T DE 88104468 T DE88104468 T DE 88104468T DE 287819 T1 DE287819 T1 DE 287819T1
Authority
DE
Germany
Prior art keywords
imidazol
ylmethyl
methyl
namely
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198888104468T
Other languages
English (en)
Inventor
Vassil Stefanov Penfield New York 14526 Georgiev
George Byron Avon New York 14414 Mullen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pennwalt Corp
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/036,839 external-priority patent/US4769469A/en
Priority claimed from US07/104,702 external-priority patent/US4769470A/en
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of DE287819T1 publication Critical patent/DE287819T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (13)

88 104 468.9 6376 WK/eg PATENTANSPRÜCHE
1. Verbindung der Formel
und die pharmazeutisch annehmbaren Säureadditionssalze davon in der Form ihrer Enantiomeren oder Gemischen ihrer Enantiomeren mit Einschluß der diastereoisomeren Paare solcher Enantiomeren,
X für Sauerstoff oder Schwefel steht und
R aus Phenyl-, substituierten Phenyl- und Phenoxymethyl-, substituierten Phenoxymethyl-, Phenylthiomethyl- und (substituierten Phenyl)thiomethyl-Gruppen ausgewählt ist, wobei die Substituenten der substituierten Phenyl-, Phenylmethoxy und Phenylthiomethyl-Gruppen aus Halogen, Nitro, Niedrigalkyl, Niedrigalkoxy und Kombinationen davon ausgewählt sind.
2. Verbindung nach Anspruch 1, nämlich 5-(4-Chlorphenyl)-3-(2-furanyl)-3-(lH-imidazol-1-ylmethyl)-2-methylisoxazolidin.
3. Verbindung nach Anspruch 1, nämlich 3-(2-Furanyl)-3-(lH-imidazol-1-ylmethyl)-2-methyl-5-(3-nitrophenyl)-isoxazolidin.
4. Verbindung nach Anspruch 1, nämlich 5-(4-Chlorphenoxymethyl)-3-(2-furanyl)-2-(lH-imidazol-1-ylmethyl)-2-methylisoxazolidin.
5. Verbindung nach Anspruch 1, nämlich 3-(2-Furanyl)-3-(IH-imidazol-1-ylmethyl)-5-(4-methoxyphenoxymethyl)-2-methyI-isoxazolidin.
6. Verbindung nach Anspruch 1, nämlich 3-(lH-Imidazol-1-ylmethyl)-2-methy1-5-phenyl-3-(2-thienyl)-isoxazolidin.
7. Verbindung nach Anspruch 1, nämlich 5-(4-Chlorphenyl)-3-(lH-imidazol-1-ylmethyl)-2-methyl-3-(2-thienyl)-isoxazolidin.
8. Verbindung nach Anspruch 1, nämlich 3-(lH-Imidazol-1-ylmethyl)-2-methyl-5-(3-nitrophenyl)-3-(2-thienyl)-isoxazolidin.
9. Verbindung nach Anspruch 1, nämlich 3-(lH-Imidazol-1-ylmethyl)-2-methyl-5-(phenoxymethyl)-3-(2-thienyl)-isoxazolidin.
10. Verbindung nach Anspruch 1, nämlich 5-[ (4-Chlorphenoxy)-methyl]-3-(lH-imidazol-1-ylmethy1)-2-methyl-3-(2-thienyl)-isoxazolidin.
11. Verbindung nach Anspruch 1, nämlich 3-(lH-Imidazol-1-ylmethyl)-2-methyl-5-[[(4-methylpheny1)thio]methyl]-3-(2-thienyl)-isoxazolidin.
12. Verbindung nach Anspruch 1, nämlich 5-[[(4-Chlorphenyl)-thio]methyl]-3-(lH-imidazol-1-ylmethyl)-2-methyl-3-(2-thienyl ) -isoxazolidin.
13. Verbindung nach Anspruch 1, nämlich 3-(lH-Imidazol-1-ylmethyl)-5-[(4-methoxyphenoxy)methyl]-2-methyl-3-(2-thienyl)-isoxazolidin.
DE198888104468T 1987-04-10 1988-03-21 5-(phenyl oder phenoxyalkyl)-3-(2-furanyl oder 2-thienyl)-3-(1h-imidazol-1-ylmethyl)-2-methylisoxazolidine. Pending DE287819T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/036,839 US4769469A (en) 1987-04-10 1987-04-10 5-(phenyl or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US07/104,702 US4769470A (en) 1987-10-02 1987-10-02 5-(phenyl or phenoxyalkyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines

Publications (1)

Publication Number Publication Date
DE287819T1 true DE287819T1 (de) 1989-02-16

Family

ID=26713551

Family Applications (1)

Application Number Title Priority Date Filing Date
DE198888104468T Pending DE287819T1 (de) 1987-04-10 1988-03-21 5-(phenyl oder phenoxyalkyl)-3-(2-furanyl oder 2-thienyl)-3-(1h-imidazol-1-ylmethyl)-2-methylisoxazolidine.

Country Status (13)

Country Link
EP (1) EP0287819A1 (de)
JP (1) JPS63313785A (de)
KR (1) KR880012598A (de)
AR (1) AR245124A1 (de)
AU (1) AU1316288A (de)
DE (1) DE287819T1 (de)
DK (1) DK190788A (de)
ES (1) ES2006440A4 (de)
FI (1) FI881659A7 (de)
IL (1) IL85691A0 (de)
NO (1) NO881529L (de)
PH (1) PH23282A (de)
PT (1) PT87104B (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3465000A (en) * 1966-12-28 1969-09-02 R & L Molecular Research Ltd Basic esters of certain substituted isoxazole-4-carboxylic acids
NL137326C (de) * 1967-08-26
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
IL85691A0 (en) 1988-08-31
AR245124A1 (es) 1993-12-30
EP0287819A1 (de) 1988-10-26
JPS63313785A (ja) 1988-12-21
DK190788A (da) 1988-10-11
PH23282A (en) 1989-06-23
ES2006440A4 (es) 1989-05-01
PT87104B (pt) 1992-07-31
FI881659L (fi) 1988-10-11
NO881529D0 (no) 1988-04-08
PT87104A (pt) 1988-04-01
FI881659A0 (fi) 1988-04-08
KR880012598A (ko) 1988-11-28
NO881529L (no) 1988-10-11
AU1316288A (en) 1988-10-13
DK190788D0 (da) 1988-04-08
FI881659A7 (fi) 1988-10-11

Similar Documents

Publication Publication Date Title
DE60018989T2 (de) N-carbamoyloxyalkyl-substituierte azolium-verbindungen
ZA200508623B (en) Use of derivatives of 2,4-dihydro-[1,2,4]triazole-3-thione as inhibitors of the enzyme myeloperoxidase (MPO)
EP0276432A3 (de) Schädlingsbekämpfungsmittel
JP2009507080A5 (de)
KR890014500A (ko) 트리아졸 유도체, 그의 제법 및 살균제로서의 그의 용도
KR970704738A (ko) 항-헬리코박터제인 아졸론의 우레아 및 티오우레아 유도체(Anti-helicobacter urea and thiourea derivatives of azolones)
JP2001517652A5 (de)
IL70197A0 (en) Hydroxyalkyl-azolyl derivatives substituted by heterocyclic substituents,their preparation and their use as fungicides
KR910016329A (ko) Npy길항 작용을 하는 약학적 물질 제조용 구아니딘 유도체의 용도
MA21227A1 (fr) 4-4-4-2-(2,4-difluorophenyl)-2-2(1h-azolylmethyl)-1,3-dioxolanne-'-yl methoxy phenyl-1-piperazinyl phenyl triazolones.
RU97115290A (ru) Соединения азола, способ получения указанных соединений и их применение
DE287819T1 (de) 5-(phenyl oder phenoxyalkyl)-3-(2-furanyl oder 2-thienyl)-3-(1h-imidazol-1-ylmethyl)-2-methylisoxazolidine.
CS262891A3 (en) Antifungal triazole derivatives, process of their preparation and use
EP0829478A2 (de) N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel
JP2002512235A5 (de)
GR81978B (de)
KR920004382A (ko) 광학활성인 트리아졸 유도체 및 조성물
JP2965532B2 (ja) Ｎ−ベンジルアゾリウム誘導体
US4428958A (en) Therapeutic compounds containing β-lactams
KR890700582A (ko) 살진균성 아미노트리아졸 및 아미노이미다졸
KR960009422B1 (en) 4-(ardylamino)piperidinebutanamide derivatives
IL70718A (en) 2-phenyl-1-(imidazo-2-yl or 1,2,4-triazol-3-yl or tetrazol-5-yl)-3-(1h-1,2,4-triazol-1-yl)propan-2-ol derivatives,their preparation and pharmaceutical compositions containing them
KR880002865A (ko) 5-치환된-3- 페닐-3-(1h- 이미다졸-1-일메틸)-2- 메틸이속사졸리딘
KR830009092A (ko) 2-아릴-2-1-h-아조일(알킬)-감마-부티로락톤
JPH09505083A (ja) トリアゾール化合物およびその製造方法