DE2421638A1 - SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERS - Google Patents
SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERSInfo
- Publication number
- DE2421638A1 DE2421638A1 DE2421638A DE2421638A DE2421638A1 DE 2421638 A1 DE2421638 A1 DE 2421638A1 DE 2421638 A DE2421638 A DE 2421638A DE 2421638 A DE2421638 A DE 2421638A DE 2421638 A1 DE2421638 A1 DE 2421638A1
- Authority
- DE
- Germany
- Prior art keywords
- skin
- substituted
- contain
- hydroxyl groups
- skin care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004909 Moisturizer Substances 0.000 title claims description 7
- 239000000126 substance Substances 0.000 claims description 18
- 125000005263 alkylenediamine group Chemical group 0.000 claims description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- 239000011814 protection agent Substances 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000000419 plant extract Substances 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims description 2
- 150000004820 halides Chemical class 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 150000003893 lactate salts Chemical class 0.000 claims description 2
- 150000004701 malic acid derivatives Chemical class 0.000 claims description 2
- 150000003891 oxalate salts Chemical class 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 235000021317 phosphate Nutrition 0.000 claims description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
- 150000003890 succinate salts Chemical class 0.000 claims description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 2
- 150000003892 tartrate salts Chemical class 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 150000003841 chloride salts Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 239000006071 cream Substances 0.000 description 12
- 210000002615 epidermis Anatomy 0.000 description 11
- 239000000203 mixture Substances 0.000 description 8
- 241000282898 Sus scrofa Species 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- -1 Pumarates Chemical class 0.000 description 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 150000002924 oxiranes Chemical class 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- FKJVYOFPTRGCSP-UHFFFAOYSA-N 2-[3-aminopropyl(2-hydroxyethyl)amino]ethanol Chemical compound NCCCN(CCO)CCO FKJVYOFPTRGCSP-UHFFFAOYSA-N 0.000 description 2
- 241001440269 Cutina Species 0.000 description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000010531 catalytic reduction reaction Methods 0.000 description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- JGVZJRHAZOBPMW-UHFFFAOYSA-N 1,3-bis(dimethylamino)propan-2-ol Chemical compound CN(C)CC(O)CN(C)C JGVZJRHAZOBPMW-UHFFFAOYSA-N 0.000 description 1
- UYBWIEGTWASWSR-UHFFFAOYSA-N 1,3-diaminopropan-2-ol Chemical compound NCC(O)CN UYBWIEGTWASWSR-UHFFFAOYSA-N 0.000 description 1
- CWKVFRNCODQPDB-UHFFFAOYSA-N 1-(2-aminoethylamino)propan-2-ol Chemical compound CC(O)CNCCN CWKVFRNCODQPDB-UHFFFAOYSA-N 0.000 description 1
- DHHDBOQJJJGUQC-UHFFFAOYSA-N 1-[2-aminoethyl(2-hydroxypropyl)amino]propan-2-ol Chemical compound CC(O)CN(CCN)CC(C)O DHHDBOQJJJGUQC-UHFFFAOYSA-N 0.000 description 1
- QLSQYTKEUVPIJA-UHFFFAOYSA-N 2-(1-aminopropan-2-ylamino)ethanol Chemical compound NCC(C)NCCO QLSQYTKEUVPIJA-UHFFFAOYSA-N 0.000 description 1
- GHKSKVKCKMGRDU-UHFFFAOYSA-N 2-(3-aminopropylamino)ethanol Chemical compound NCCCNCCO GHKSKVKCKMGRDU-UHFFFAOYSA-N 0.000 description 1
- IJESMHJDHLCBPG-UHFFFAOYSA-N 2-(3-morpholin-4-ylpropylamino)ethanol Chemical compound OCCNCCCN1CCOCC1 IJESMHJDHLCBPG-UHFFFAOYSA-N 0.000 description 1
- ZKFFSBRJTHFVCM-UHFFFAOYSA-N 2-(3-piperidin-1-ylpropylamino)ethanol Chemical compound OCCNCCCN1CCCCC1 ZKFFSBRJTHFVCM-UHFFFAOYSA-N 0.000 description 1
- CYOIAXUAIXVWMU-UHFFFAOYSA-N 2-[2-aminoethyl(2-hydroxyethyl)amino]ethanol Chemical compound NCCN(CCO)CCO CYOIAXUAIXVWMU-UHFFFAOYSA-N 0.000 description 1
- CDVMRBKZDAJYGH-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;propane-1,2-diol Chemical compound CC(O)CO.OCCN(CCO)CCO CDVMRBKZDAJYGH-UHFFFAOYSA-N 0.000 description 1
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 description 1
- YOPXOPTZHNKPTA-UHFFFAOYSA-N 3-[2-aminoethyl(2-hydroxyethyl)amino]propane-1,2-diol Chemical compound NCCN(CCO)CC(O)CO YOPXOPTZHNKPTA-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000014150 Myroxylon pereirae Nutrition 0.000 description 1
- 244000302151 Myroxylon pereirae Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- LHIJANUOQQMGNT-UHFFFAOYSA-N aminoethylethanolamine Chemical compound NCCNCCO LHIJANUOQQMGNT-UHFFFAOYSA-N 0.000 description 1
- 150000001541 aziridines Chemical class 0.000 description 1
- RERVRRLGFUNERS-UHFFFAOYSA-N boron;propane-1,2,3-triol Chemical compound [B].OCC(O)CO RERVRRLGFUNERS-UHFFFAOYSA-N 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 235000020379 cucumber juice Nutrition 0.000 description 1
- 238000007278 cyanoethylation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- VOCRJGITGXTNNG-UHFFFAOYSA-N dimethylazanium propan-2-ol chloride Chemical compound CC(C)O.[Cl-].C[NH2+]C VOCRJGITGXTNNG-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- QJWQYOHBMUQHGZ-UHFFFAOYSA-N ethanol;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound CCO.OC(=O)CC(O)(C(O)=O)CC(O)=O QJWQYOHBMUQHGZ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- FWFGVMYFCODZRD-UHFFFAOYSA-N oxidanium;hydrogen sulfate Chemical compound O.OS(O)(=O)=O FWFGVMYFCODZRD-UHFFFAOYSA-N 0.000 description 1
- 125000000466 oxiranyl group Chemical group 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000009864 tensile test Methods 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/002—Aftershave preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
"Hautpflege- und Hautschutzmittel mit einem Gehalt an Haut-Feuchthaltemitteln" "Skin care and skin protection agents with a content of skin moisturizers"
Die Erfindung betrifft Hautpflege- und Hautschutzmittel mit einem Gehalt an Hydroxylgruppen enthaltenden substituierten beziehungsweise unsubstituierten Alkylendiaminen oder deren Salzen als HautrFeuchthaltemittel.The invention relates to skin care and skin protection agents a content of substituted or unsubstituted alkylenediamines containing hydroxyl groups or their Salts as skin moisturizers.
Es ist allgemein bekannt, daß zu den Schutzmaßnahmen der gesunden Haut neben anderen Paktoren eine gewisse Hygroskopizität gehört. Werden die Substanzen, auf denen diese Hygroskopizität, sowie ihre laufende Wiederherstellung beruhen, der Haut durch Umwelteinflüsse, wie wiederholtes Waschen mit stark netzenden und extrahierenden Stoffen, Chemikalieneinflüsse, starke Witterungseinflüsse entzogen, so treten Veränderungen in der Hornschicht auf, durch die die Schutzwirkung der Haut gegen schädigende Umwelteinflüsse stark herabgesetzt werden kann.It is well known that, in addition to other factors, there are certain factors that contribute to the protective measures of healthy skin Hygroscopicity heard. Become the substances on which this hygroscopicity, as well as its ongoing restoration the skin due to environmental influences, such as repeated washing with strongly wetting and extracting substances, Chemical influences, removed from strong weather influences, changes occur in the horny layer, which can greatly reduce the protective effect of the skin against harmful environmental influences.
Es bestand daher die Aufgabe, Hautpflege- und Hautschutz- " mittel zu entwickeln, durch die die Punktionsfähigkeit der Haut trotz schädigender Umwelteinflüsse voll bzw. in verstärktem Maße erhalten bleibt und im Falle einer eingetretenen Schädigung die Wiederherstellung der Hornhaut wirkungsvoll unterstützt wird.It was therefore the task of skin care and skin protection " To develop means through which the puncture ability of the skin is fully or intensified despite damaging environmental influences Dimensions are retained and, in the event of damage, the restoration of the cornea is effectively supported.
Diese Aufgabe wurde dadurch gelöst, daß man Hautpflege- und Hautschutzmittel auf Basis üblicher Bestandteile, wie Emulgatoren, FettSubstanzen, Pflanzenauszüge, Lösungsmittel, Duftstoffe, Verdickungs-, Konservierungsmittel verwendet mitThis object has been achieved by using skin care and skin protection agents based on conventional ingredients, such as emulsifiers, Fatty substances, plant extracts, solvents, fragrances, Thickeners, preservatives used with
509847/0966509847/0966
Henkel &Cie GmbHHenkel & Cie GmbH
Blatt 2 zur Patentanmeldung D 4 918 PatentabteilungSheet 2 to patent application D 4 918 patent department
einem Gehalt an Hydroxylgruppen enthaltenden substituierten beziehungsweise unsubstituierten Alkylendiaminen oder deren Salzen der allgemeinen Formela content of substituted or unsubstituted alkylenediamines containing hydroxyl groups or their Salts of the general formula
R1R2N - R3 - NR4R5,R 1 R 2 N - R 3 - NR 4 R 5 ,
in der R1, R2, R4 und Rj. unabhängig voneinander für Wasserstoff, "eine Alkylgruppe mit 1-4 Kohlenstoffatomen, eine Hydroxyalkyl- oder Dihydroxyalkylgruppe mit 1-4 Kohlenstoffatomen, wobei Rj. und Rj. auch gemeinsam einen gesättigten heterocyclischen 5- oder 6-Ring, der noch ein weiteres H Heteroatom wie Sauerstoff oder Stickstoff enthalten und/oder durch eine Oxo- oder Hydroxyalkylgruppe substituiert sein kann, bilden können und R, für eine Alkylengruppe mit 2-4 Kohlenstoff atome stehen können, mit der Maßgabe, daß mindestens einer der Reste R1, R2, R,, Ru und R,- eine oder mehrere Hydroxylgruppen enthält, in einer Menge von 1-20 Gewichtsprozent, vorzugsweise 3-10 Gewichtsprozent, bezogen auf das gesamte Mittel.in which R 1 , R 2 , R 4 and Rj. independently of one another represent hydrogen, "an alkyl group with 1-4 carbon atoms, a hydroxyalkyl or dihydroxyalkyl group with 1-4 carbon atoms, where Rj. and Rj. together also represent a saturated heterocyclic 5 - Or 6-ring, which can also contain another H heteroatom such as oxygen or nitrogen and / or can be substituted by an oxo or hydroxyalkyl group, and R can stand for an alkylene group with 2-4 carbon atoms, with the proviso that at least one of the radicals R 1 , R 2 , R 1, Ru and R 1 - contains one or more hydroxyl groups, in an amount of 1-20 percent by weight, preferably 3-10 percent by weight, based on the total agent.
Diese erfindungsgemäß einzusetzenden Produkte sind in vorzüglicher Weise geeignet, die Wasserretention der Haut aufrechtzuerhalten bzw. wiederherzustellen und hierdurch die Haut weich und flexibel und voll funktionsfähig zu erhalten.These products to be used according to the invention are eminently suitable for reducing water retention Maintain or restore skin and thereby make the skin soft and flexible and fully functional to obtain.
Die Herstellung der -erfindungsgemäß als Haut-Feuchthaltemittel zu verwendenden Verbindungen kann nach allgemein bekannten Verfahren erfolgen, zum Beispiel durch katalytische Reduktion der Cyanäthylierungsprodukte von primären oder sekundären hydroxyalkyl- beziehungsweise dihydroxyalkylsubstituierten Aminen, wie dies z. B. für 4-(3-Aminopropyl)-l-piperazinäthanol in der amerikanischen Patentschrift 3 101 338 (Ref. Chemical Abstracts Vol. 60, Spalte 2915) beschrieben ist, oder durch Alkylierung solcherThe production of the invention as a skin moisturizer Compounds to be used can be made by generally known processes, for example by catalytic Reduction of the cyanoethylation products of primary or secondary hydroxyalkyl or dihydroxyalkyl substituted Amines, such as B. for 4- (3-aminopropyl) -l-piperazine ethanol in the American patent 3 101 338 (Ref. Chemical Abstracts Vol. 60, column 2915), or by alkylation of such
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hydroxyalkyl- oder dihydroxyalkylsubstituierter Amine mit Aziridinen. Eine andere Möglichkeit zur Herstellung besteht in der Umsetzung geeigneter Alkylendiamine mit Oxiranringe enthaltenden Verbindungen wie z. B. Äthylenoxid, Propylenoxid oder Glycidol. Auf diese Weise können 1 bis η Hydroxyalkyl- beziehungsweise Dihydroxyalkylgruppen in Alkylendiamine mit η Stickstoff-Wasserstoff-Bindungen durch geeignete Wahl des Molverhältnisses von Alkylendiamin zu Epoxid eingeführt werden, wie dies von M. S. Malinowskii in der Monographie "Epoxides and their Derivatives", Israel Program for Scientific Translations, Jerusalem I965» beschrieben ist. Zu der Verbindung 1,3-Bis-(dimethylamine)-propanol-2 kann man gemäß vorgenannter Literaturstelle Seite 229 durch Kondensation von 1 Mol Epichlorhydrin mit 2 Mol Dimethylamin gelangen.hydroxyalkyl or dihydroxyalkyl substituted amines with aziridines. There is another possibility for production in the implementation of suitable alkylenediamines with compounds containing oxirane rings such. B. ethylene oxide, propylene oxide or glycidol. In this way, 1 to η hydroxyalkyl or dihydroxyalkyl groups can be found in alkylenediamines with η nitrogen-hydrogen bonds introduced by suitable choice of the molar ratio of alkylenediamine to epoxide as reported by M. S. Malinowskii in the monograph "Epoxides and their Derivatives", Israel Program for Scientific Translations, Jerusalem I965 ». The compound 1,3-bis- (dimethylamine) -propanol-2 can can be obtained according to the aforementioned reference on page 229 by condensation of 1 mole of epichlorohydrin with 2 moles of dimethylamine.
Erfindungsgemäß einzusetzende Hydroxylgruppen enthaltende, substituierte, beziehungsweise unsubstituierte Alkylendiamine sind zum Beispiel N-(2-Hydroxy-äthyl)-äthylendiamin, N-(2-Hydroxypropyl)-äthylendiamin, N,N-Bis-(2-hydroxy-äthyl)-äthylendiamin, N,N-Bis-(2-hydroxy-propyl)-äthylendiamin, N,N,N',N·-Tetrakis-(2-hydroxy-äthylJ-äthylendiamin, N,N,N1,N'-Tetrakis-(2-hydroxypropyl )-äthylendiamin, N-(2-Hydroxyäthyl)-N-(2,3-dihydroxy-propyl)-äthylendiamin, N ,N-Bis- (2-hydroxyäthy 1) -N' ,N' -bis- (2,3-dihydroxypropyl)-äthylendiamin, 2-(2-Hydroxyäthy1-amino)-propylamin, 3-(2-Hydroxyäthyl-amino)-propylamin, 3-(Bis-(2-hydroxyäthyl)-amino) -propylamin, 1.- (3-Amino-propyl) -1I- (2-hydroxyäthy 1) piperazin, 1-(3-(2-Hydroxyäthyl-amino)-propyl-)-4-(2-hydroxyäthyl )-piperazin, 4-(3-(2-Hydroxyäthyl-amino)-propyl)-morpholin, N-(3-(2-Hydroxyäthyl-amino)-propyl)-piperidin, N-(3-(Bis)-2-hydroxyäthyl-amino)-propyl)-pyrrolidin-2-on, 1,3-Diaminopropan-2-ol, l,3-Bis-(dimethylamino)-propan-2-ol, l-Amino-3-(bis-(2-hydroxyäthyl)-amino)-propan-2-ol. Sie finden in den Hautpflege- und Hautschutzmitteln vorwiegend in Form ihrer · Salze Verwendung,Substituted or unsubstituted alkylenediamines containing hydroxyl groups to be used according to the invention are, for example, N- (2-hydroxyethyl) ethylenediamine, N- (2-hydroxypropyl) ethylenediamine, N, N-bis (2-hydroxyethyl) ethylenediamine , N, N-bis (2-hydroxy-propyl) -ethylenediamine, N, N, N ', N -Tetrakis- (2-hydroxy-ethylJ-ethylenediamine, N, N, N 1 , N'-tetrakis- (2-hydroxypropyl) ethylenediamine, N- (2-hydroxyethyl) -N- (2,3-dihydroxypropyl) ethylenediamine, N, N-bis- (2-hydroxyäthy 1) -N ', N' -bis - (2,3-dihydroxypropyl) ethylenediamine, 2- (2-hydroxyethyl-amino) -propylamine, 3- (2-hydroxyethyl-amino) -propylamine, 3- (bis- (2-hydroxyethyl) -amino) -propylamine , 1.- (3-Amino-propyl) - 1 I- (2-hydroxyäthy 1) piperazine, 1- (3- (2-Hydroxyäthyl-amino) -propyl-) - 4- (2-hydroxyethyl) -piperazine, 4- (3- (2-Hydroxyethyl-amino) -propyl) -morpholine, N- (3- (2-Hydroxyethyl-amino) -propyl) -piperidine, N- (3- (bis) -2-hydroxyethyl-amino ) propyl) pyrrolidin-2-one, 1,3-diaminopropan-2-ol, 1,3-bis (dimethylamino) propan-2-ol, l-amino -3- (bis- (2-hydroxyethyl) amino) propan-2-ol. They are mainly used in skin care and skin protection products in the form of their salts,
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Als Salze der vorstehend aufgeführten Hydroxylgruppen enthaltenden substituierten, beziehungsweise unsubstituierten Alkylendiamine kommen zum Beispiel die Halogenide, insbesondere Chloride, Sulfate, Phosphate, Acetate, Lactate, Tartrate, Citrate, Glykolate, Oxalate, Pumarate, Succinate und Malate in Frage. Die Salze werden vorzugsweise so eingestellt, daß sie in konzentrierter wäßriger Lösung einen pH-Wert von 6 aufweisen.As salts of the substituted or unsubstituted ones containing hydroxyl groups listed above Alkylenediamines come, for example, the halides, in particular chlorides, sulfates, phosphates, acetates, lactates, Tartrates, Citrates, Glycolates, Oxalates, Pumarates, Succinates and Malates in question. The salts are preferably adjusted so that they have a pH of 6 in concentrated aqueous solution.
Sämtliche vorgenannten Salze stellen farblose und geruchlose völlig stabile Produkte dar, die eine ausgezeichnete physiologische Verträglichkeit besitzen und keine nachteiligen Auswirkungen auf die mit ihnen versetzten Hautpflege- und Hautschutzmittel haben.All of the aforementioned salts are colorless and odorless, completely stable products, which are excellent have physiological compatibility and have no adverse effects on the skin care products to which they are applied. and have skin protectants.
Als Hautpflege- und Hautschutzmittel, denen durch den Zusatz der erfindungsgemäß zu verwendenden, Hydroxylgruppen enthaltenden substituierten, beziehungsweise unsubstituierten Alkylendiamine oder deren Salzen besondere hautpflegende Eigenschaften verliehen werden, sind Tagescremes, Babycremes, Nacht- und Nährcremes, Reinigungscremes, Hautschutzcremes, Glycerincremes, Cremes mit speziellen Zu-Sätzen tierischer und pflanzlicher Herkunft, Sonnenschutzcremes und Sonnenschutzemulsionen, Gesichtswasser, Rasierwasser zu nennen. Die Einarbeitung in die Hautpflege- und Hautschutzmittel kann in bekannter Weise durch einfaches Einrühren bzw. Auflösen erfolgen. Neben den erfindungsgemäß einzusetzenden, Hydroxylgruppen enthaltenden, substituierten beziehungsweise unsubstituierten Alkylendiaminen oder deren Salzen können die kosmetischen Präparationen die in diesen üblicherweise vorhandenen Bestandteile, wie z. B. Emulgatoren, Fettsubstanzen, Pflanzenauszüge, Konservierungsmittel, Duftstoffe, Lösungsmittel in den herkömmlichen Mengen enthalten.As skin care and skin protection agents, those by the addition of the hydroxyl groups to be used according to the invention substituted or unsubstituted alkylenediamines or their salts are particularly skin-care products Properties are given, are day creams, baby creams, night and nourishing creams, cleansing creams, skin protection creams, Glycerine creams, creams with special additives of animal and vegetable origin, sun protection creams and sunscreen emulsions, facial tonics, aftershave lotions. Familiarization with skin care and Skin protection agents can be made in a known manner by simply stirring in or dissolving. In addition to the invention substituted or unsubstituted alkylenediamines containing hydroxyl groups to be used or the salts thereof, the cosmetic preparations can contain the constituents usually present in them, such as z. B. emulsifiers, fatty substances, plant extracts, preservatives, Contains fragrances and solvents in conventional amounts.
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Der pH-Wert der Hautpflege- und Hautschutzmittel kann sich im Bereich von sauer bis neutral bewegen und wird zweckmäßigerweise auf schwach saure Werte um pH 6 eingestellt. The pH value of the skin care and skin protection agents can and will move in the range from acidic to neutral expediently adjusted to weakly acidic values around pH 6.
Die nachfolgenden Beispiele sollen den Gegenstand der Erfindung näher erläutern, ohne ihn jedoch hierauf zu beschränken. The following examples are intended to explain the subject matter of the invention in more detail without, however, restricting it thereto.
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Von den erfindungsgemäß als Haut-FEuchthaltemittel einzusetzenden, Hydroxylgruppen enthaltenden, substituierten beziehungsweise unsubstituierten Alkylendiaminen wurden nachstehend aufgeführte Verbindungen den Prüfungen unterworfen und in Rezepturen verwendet.Of those to be used according to the invention as skin moisturizers, Substituted or unsubstituted alkylenediamines containing hydroxyl groups were The compounds listed below are subjected to the tests and used in formulations.
A) Jj-(3-Aminopropyl)-l-piperazinoäthanolA) Ij- (3-aminopropyl) -l-piperazinoethanol
Das Produkt wurde entsprechend den Angaben der amerikanischen Patentschrift 3 101 338 durch Umsetzung von 1-Piperazinäthanol mit Acrylnitril bei 110 - 1200C und katalytische Reduktion des gewonnenen 4-(2-cyanoäthyl)-l-piperazinäthanols bei Raumtemperatur erhalten,The product was according to the specifications of the American Patent 3,101,338 by reacting 1-Piperazinäthanol with acrylonitrile at 110 - 120 0 C and obtained catalytic reduction of the obtained 4- (2-cyanoethyl) -l-piperazinäthanols at room temperature,
B) N-(3-Aminopropyl)-diäthanolaminB) N- (3-aminopropyl) diethanolamine
Die Herstellung des Produktes erfolgte durch Umsetzung von 1 Mol 1,3-Diaminopropan mit 2 Mol Äthylenoxid analog den Angaben von M. S. Malinovskii in der Monographie "Epoxides and their Derivatives","Israel Program for Scientific Translations", Jerusalem I965.The product was prepared analogously by reacting 1 mole of 1,3-diaminopropane with 2 moles of ethylene oxide the information from M. S. Malinovskii in the monograph "Epoxides and their Derivatives", "Israel Program for Scientific Translations ", Jerusalem I965.
C) N- (2-Hydroxyäthy.l) -äthylendiamin-hydrochloridC) N- (2-Hydroxyäthy.l) -äthylenediamine hydrochloride
Das Produkt wurde analog den Angaben von M.S. Malinovskii in vorgenannter Monographie durch Umsetzung von Äthylendiamin mit Äthylenoxid und anschließender Neutralisation (pH 6) mit HCl erhalten.The product was prepared analogously to the information provided by M.S. Malinovskii in the aforementioned monograph by converting ethylenediamine obtained with ethylene oxide and subsequent neutralization (pH 6) with HCl.
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D)N-(2-Hydroxypropyl)-äthylendiamin-hydrochloridD) N- (2-hydroxypropyl) ethylenediamine hydrochloride
Die Herstellung des Produktes erfolgte analog den Angaben von M. S. Malinovskii durch Umsetzung von Äthylendiamin mit Propylenoxid und Neutralisation mit HCl.·The product was produced analogously to the information provided by M. S. Malinovskii by reacting Ethylenediamine with propylene oxide and neutralization with HCl.
E) Ν,Ν,Ν1,Ν1-Tetrakis-(2-hydroxyäthyl)-äthylendiaminE) Ν, Ν, Ν 1 , Ν 1 -Tetrakis- (2-hydroxyethyl) -ethylenediamine
Das Produkt wurde analog den Angaben von M. S. Malinovskii durch Umsetzung von 1 Mol Äthylendiamin mit 1I Mol Äthylenöxid erhalten.The product was obtained analogously to the information from MS Malinovskii by reacting 1 mol of ethylene diamine with 1 l mol of ethylene oxide.
P) 1,3-Bis-(dimethylamine)-propan-2-ol-hydrochloridP) 1,3-bis (dimethylamine) propan-2-ol hydrochloride
Die Herstellung des Produktes erfolgte analog den Angaben von M. S. Malinovskii durch Umsetzung von Epichlorhydrin mit 2 Mol Dimethylamin und Neutralisation mit HCl.The product was produced analogously to the information provided by M. S. Malinovskii by reacting Epichlorohydrin with 2 moles of dimethylamine and neutralization with HCl.
Das günstige Verhalten der erfindungsgemäß einzusetzenden Verbindungen im Hinblick auf Wasseraufnahmefähigkeit und Wasserrückhaltevermögen wurde mittels nachstehend näher beschriebener Prüfmethoden festgestellt.The favorable behavior of the compounds to be used according to the invention with regard to water absorbency and The water retention capacity was determined using the test methods described in more detail below.
Die Bestimmung des Wasseraufnahmevermögens erfolgte durch Messung der Gewichtszunahme bei Lagerung bei 100 % relativer Luftfeuchtigkeit über 48 Stunden in mg Wasser pro 100 mg Substanz.The water absorption capacity was determined by measuring the increase in weight on storage at 100 % relative humidity for 48 hours in mg of water per 100 mg of substance.
Das Wasserretentionsvermögen wurde ermittelt durch Bestimmung des Restwassergehaltes einer mit 300 mg Wasser pro 100 mg Substanz befeuchteten Probe nach Lagerung bei 0 % relativer Feuchtigkeit unter einem Druck von 12 Torr während einer Zeit von k5 Minuten, 1 1/2 Stunden und 8 Stunden als mg Wasser pro 100 mg Substanz. ' 'The water retention capacity was determined by determining the residual water content of a sample moistened with 300 mg of water per 100 mg of substance after storage at 0 % relative humidity under a pressure of 12 Torr for a period of k5 minutes, 11/2 hours and 8 hours as mg of water per 100 mg of substance. ''
Hierbei wurden die in nachstehender Tabelle 1 aufgeführten Meßwerte erhalten.The measured values listed in Table 1 below were obtained.
c η η ο / η ι π ο C c η η ο / η ι π ο C
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gruppen enthaltenden, substituierten bzw. unsubstituierten
AlkylendiaminenWater retention and water absorption capacity of hydroxyl
group-containing, substituted or unsubstituted
Alkylenediamines
mg/100 mg Substanz
nach Ij 8 StundenWater absorption in
mg / 100 mg of substance
after Ij 8 hours
Der vorstehenden Tabelle ist neben der starken Wasseraufnahmefähigkeit auch das beachtliche Wasserretentionsvermögen der erfindungsgemäß einzusetzenden Verbindungen und damit ihre gute Eignung als Haut-Peuchthaltemittel in Hautpflege- und Hautschutzmitteln zu entnehmen.The table above is next to the strong water absorbency also the considerable water retention capacity of the compounds to be used according to the invention and thus their good suitability as a skin-holding agent in skin care and skin care products Refer to skin protection agents.
Als weitere Prüfmethoden wurden ein Verfahren zur Ermittlung der Gleichgewichtsfeuchte, die ein Maß für das Wasserretentionsvermögen darstellt und die Bestimmung der Wasserretention, Rehydratation und Elastizität imprägnierter Schweineepidermis benutzt.Another test method was a method of determination the equilibrium moisture content, which is a measure of the water retention capacity and the determination of the water retention, Rehydration and elasticity of impregnated pig epidermis are used.
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INSPECTEDINSPECTED
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1) Ermittlung der Gleichgewichtsfeuchte 1) Determination of the equilibrium moisture content
Die zu untersuchenden Substanzen (ca. 300 - 500 mg) wurden mit einer definierten Menge Wasser angefeuchtet • und bei 23°C 24 Stunden verschiedenen relativen Luftfeuchtigkeiten (1 JS, '30 *, 47 5δ, 65 %, 89 % und 100 % relativer Feuchtigkeit) ausgesetzt. Die aufgenommene bzw. abgegebene Wassermenge wurde gravimetrisch bestimmt und graphisch aufgetragen. Aus den hieraus resultierenden Kurven kann auf diejenige relative Feuchtigkeit geschlossen werden, bei der weder Wasserabgabe noch Wasseraufnahme erfolgt. Dieser Wert, der als Gleichgewichtsfeuchte bezeichnet wird, ist ein Maß für das Wasserretentionsvermögen einer Substanz. Je niedriger der Wert liegt, um so positiver ist das Produkt zu beurteilen.The substances to be examined (approx. 300 - 500 mg) were moistened with a defined amount of water • and at 23 ° C for 24 hours, different relative humidities (1 JS, '30 *, 47 5δ, 65 %, 89 % and 100 % relative) Moisture). The amount of water absorbed or released was determined gravimetrically and plotted graphically. From the resulting curves, conclusions can be drawn about the relative humidity at which neither water is released nor water is absorbed. This value, called equilibrium moisture, is a measure of the water retention capacity of a substance. The lower the value, the more positive the product is to be assessed.
2) Messungen an der Schweineepidermis 2) Measurements on the pig epidermis
a) Gewinnung der Schweineepidermis.a) Obtaining the pig epidermis.
Unmittelbar nach dem Töten der Schweine werden die Borsten der Haut mittels einer Haarschermaschine (Scherkopf 0,1 mm) abgeschnitten. Die Schweine werden in 60° warmem Wasser ca. 3-5 Minuten gebrüht, die • Epidermis anschließend abgeschält und bei -200C bis zum Gebrauch gelagert.Immediately after the pigs have been killed, the bristles of the skin are cut off using a hair clipper (shaving head 0.1 mm). The pigs are scalded in 60 ° warm water for about 3-5 minutes, the epidermis • then peeled off and stored at -20 0 C until use.
b) Bestimmung der Wasserretention, sowie der Rehydratation imprägnierter Schweineepidermis.b) Determination of water retention and rehydration impregnated pig epidermis.
Ausgestanzte Epidermisstückchen (1x2 cm) wurden 2 Stunden in 10-prozentiger Lösung der Prüfsubstanz gebadet, unter standardisierten Bedingungen mittels einer kleinen Presse abgetupft und 24 Stunden zwischen 2 Klammern frei hängend in einem 100 ml Erlenmeyer-Punched pieces of epidermis (1x2 cm) were Bathed for 2 hours in a 10 percent solution of the test substance under standardized conditions using dabbed in a small press and hung freely between 2 clamps in a 100 ml Erlenmeyer-
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kolben bei 23°C und 30 % relativer Feuchtigkeit (eingestellt durch Schwefelsäure-Wasser-Mischüngen) getrocknet. Die Austrocknung der imprägnierten Probe auf X-% des Anfangsgewichtes wurde mit dem entsprechenden Wert der nur in Wasser gebadeten Epidermis (Blindwert) verglichen. In der Tabelle ist die Verbesserung der Wasserretention, sowie der Rehydratation gegenüber dem Blindwert in Δ % HpO angegeben. Die Abweichungen betrugen bei den jeweiligen Doppelversuchen maximal - 2 absolute Einheiten. Bei größeren Abweichungen wurde der Versuch wiederholt. Die Rehydratation wurde durch 2ii-stündige Trocknung der imprägnierten und abgetupften Schweineepidermis beiFlask dried at 23 ° C and 30 % relative humidity (adjusted by sulfuric acid-water mixtures). The desiccation of the impregnated sample to X% of the initial weight was compared with the corresponding value of the epidermis bathed only in water (blank value). The table shows the improvement in water retention and rehydration compared to the blank value in Δ% HpO. The deviations in the respective double tests were a maximum of - 2 absolute units. If there were major deviations, the experiment was repeated. The rehydration was achieved by drying the impregnated and swabbed pig epidermis for 2 i i hours
30 % relativer Feuchtigkeit und anschließende 24-stündige Inkubation bei 90 % relativer Feuchtigkeit analog bestimmt.30 % relative humidity and subsequent 24-hour incubation at 90 % relative humidity determined analogously.
c) Elastizitätsmessungen an imprägnierter Schweineepidermis c) Elasticity measurements on impregnated pig epidermis
Ausgestanzte Epidermisstückchen (1x6 cm) wurden 2 Stunden in lOiiger wäßriger Lösung der zu prüfenden Substanz gebadet und unter standardisierten Bedingungen abgetupft. Die Proben wurden zwischen 2 Klammern frei hängend bei 75 % relativer Feuchtigkeit, sowie 90 % relativer Feuchtigkeit 24 Stunden inkubiert und in einer Zwick-Zugprüfmaschine (Typ: 1402) bei 0 - 50 ρ Belastung gedehnt. Als Maß für die Elastizität wurde die Dehnung in mm angegeben, die im Hooke1sehen Bereich bei einer Belastung zwischen 5 - 30 ρ gemessen wurde.Punched out pieces of epidermis (1x6 cm) were bathed for 2 hours in 10% aqueous solution of the substance to be tested and dabbed under standardized conditions. The samples were incubated between 2 clamps at 75 % relative humidity and 90 % relative humidity for 24 hours and stretched in a Zwick tensile testing machine (type: 1402) at 0-50 ρ load. As a measure of the elasticity, the elongation was given in mm, which was measured in the Hooke 1 area with a load between 5 - 30 ρ.
Die bei den vorstehend beschriebenen Prüfungen erhaltenen Meßwerte sind nachstehender Tabelle 2 zu entnehmen.Those obtained in the tests described above Measured values can be found in Table 2 below.
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"-" nicht gemessen"-" not measured
Den vorgenannten Meßwerten ist die gute Eignung der erfindungsgemäß zu verwendenden Produkte alsThe aforementioned measured values indicate the good suitability of the products to be used according to the invention as
Feuchthaltemittel zu entnehmen.Refer to humectant.
N) I fieN) I fie
—* β Q- * β Q
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Nachstehend werden noch einige Beispiele für kosmetische Zubereitungen aufgeführt, die die erfindungsgemäß einzusetzenden Substanzen als Haut-Feuchthaltemittel enthalten.Below are some more examples of cosmetic Listed preparations which contain the substances to be used according to the invention as skin moisturizers.
Tagescreme schwach fettendDay cream weakly greasy
Fettsäurepartialglyeerid Cutina MDv Fatty acid partial glyceride Cutina MD v
Dehydag 6,0 Gew.-TeileDehydag 6.0 parts by weight
Stearinsäure : 8,0 "Stearic Acid : 8.0 "
Gemisch nichtionogener EmulgatorenMixture of non-ionic emulsifiers
Eumulgin C 700^R* Dehydag 2 Octyldodecanol Pflanzenöl Paraffinöl Triäthanolamin 1,2-Propylenglykol Produkt A Nipagin M Parfümöl WasserEumulgin C 700 ^ R * Dehydag 2 Octyldodecanol Vegetable Oil Paraffin Oil Triethanolamine 1,2-Propylene Glycol Product A Nipagin M Perfume Oil Water
Baby-CremeBaby cream
Gemisch höhermolekularer Ester, vorwiegend Mischester ausMixture of higher molecular weight esters, mainly mixed esters
Pentaerythrit-Fettsäureester und Zitronensäurefettalkohol-Pentaerythritol fatty acid ester and citric acid fatty alcohol
ester Dehymuls Ev ' Dehydag 7,0 Gew.-Teileester Dehymuls E v 'Dehydag 7.0 parts by weight
ölsäuredecylester Vaseline Wollfett Borsäure Talkum Zinkoxid Nipagin M Produkt B Wasseroleic acid decyl ester Vaseline Wool fat boric acid talc zinc oxide nipagin M product B water
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•Nachtcreme• Night cream
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-Gesichtsmaske-Face mask
Gemisch von Fettsäurepartial-Mixture of fatty acid partial
glycerid mit Emulgatoren Cutinaglyceride with emulsifiers Cutina
LE(R) DehydagLE (R) Dehydag
ölsäuredecylesteroleic acid decyl ester
VitaminölVitamin oil
Kaolinkaolin
ReisstärkeRice starch
Nipagin MNipagin M.
Produkt FProduct F
Wasserwater
Henkel &Cie GmbHHenkel & Cie GmbH
PatentabteilungPatent department
67,867.8
Rasierwasseraftershave
Oleyl-CetylalkoholOleyl cetyl alcohol
Äthanol 96 % Ethanol 96 %
Mentholmenthol
KampferFighter
PerubalsamBalsam of Peru
ParfümPerfume
Hammame1iseχtraktHammamise tract
BorsäureBoric acid
Produkt BProduct B
Produkt FProduct F
Wasserwater
GesichtswasserFacial toner
Gurkensaft Citronensäure Äthanol 96?ig Produkt A Duftstoff WasserCucumber Juice Citric Acid Ethanol 96? Ig Product A fragrance water
- 15 -- 15 -
509847/0966509847/0966
Blatt j. 5 zur Patentanmeldung D 1} 918 Palentabteilung Sheet j. 5 for patent application D 1} 918 Palentabteilung
An die Stelle der in den vorstehenden Rezepturen-genannten erfindungsgemäß zu verwendenden Verbindungen können mit gleich gutem Erfolg auch andere der aufgeführten-erfindungsgemäß einzusetzenden Produkte treten.Instead of those mentioned in the above recipes Compounds to be used according to the invention can also be other of those listed according to the invention with equally good success products to be used.
- 16 -- 16 -
509847/0966509847/0966
Claims (4)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2421638A DE2421638A1 (en) | 1974-05-04 | 1974-05-04 | SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERS |
| SE7503963A SE403045B (en) | 1974-05-04 | 1975-04-07 | SKIN AND SKIN PROTECTOR CONTAINING SKIN MOISTURIENT |
| NL7504116A NL7504116A (en) | 1974-05-04 | 1975-04-07 | SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURE RETENTION AGENTS. |
| IT22636/75A IT1037595B (en) | 1974-05-04 | 1975-04-23 | AGENT FOR THE CARE OF THE SKIN AND FOR THE PROTECTION OF THE SKIN WITH A CONTENT OF WETING AGENTS OF THE SKIN |
| GB17669/75A GB1513053A (en) | 1974-05-04 | 1975-04-29 | Skin-care and skin-protection agents containing skin moisture-containing agents |
| FR7513667A FR2269327B1 (en) | 1974-05-04 | 1975-04-30 | |
| BE155943A BE828581A (en) | 1974-05-04 | 1975-04-30 | SKIN CARE AND PROTECTION PRODUCT CONTAINING HYDROXYDIAMINES AS MOISTURIZING AGENTS |
| CH565475A CH598816A5 (en) | 1974-05-04 | 1975-05-02 | |
| AT336675A AT335622B (en) | 1974-05-04 | 1975-05-02 | SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZING PRODUCTS |
| JP50052639A JPS50154439A (en) | 1974-05-04 | 1975-05-02 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2421638A DE2421638A1 (en) | 1974-05-04 | 1974-05-04 | SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2421638A1 true DE2421638A1 (en) | 1975-11-20 |
Family
ID=5914659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2421638A Pending DE2421638A1 (en) | 1974-05-04 | 1974-05-04 | SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERS |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS50154439A (en) |
| AT (1) | AT335622B (en) |
| BE (1) | BE828581A (en) |
| CH (1) | CH598816A5 (en) |
| DE (1) | DE2421638A1 (en) |
| FR (1) | FR2269327B1 (en) |
| GB (1) | GB1513053A (en) |
| IT (1) | IT1037595B (en) |
| NL (1) | NL7504116A (en) |
| SE (1) | SE403045B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0023978A3 (en) * | 1979-08-09 | 1982-01-13 | Basf Wyandotte Corporation | Harmless cosmetic and toiletry products and method of making same |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH638051A5 (en) * | 1980-07-09 | 1983-08-31 | Labiol Sa | METHOD FOR CONTROLLING THE MOISTURIZING EFFECT OF A PRODUCT TO BE APPLIED TO THE SKIN. |
| DE3233638A1 (en) * | 1982-09-10 | 1984-03-15 | Thilo & Co Gmbh Dr | DERMATOLOGICAL PREPARATION |
| JPS60246307A (en) * | 1984-05-22 | 1985-12-06 | Shiseido Co Ltd | Oil-in-water type emulsified cosmetic |
| JPS60246306A (en) * | 1984-05-22 | 1985-12-06 | Shiseido Co Ltd | Water-in-oil type emulsified cosmetic |
| AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| JPH01238514A (en) * | 1988-03-15 | 1989-09-22 | Sunstar Inc | Skin cosmetic |
| DE3818495A1 (en) * | 1988-05-31 | 1989-12-14 | Eisenbrand Gerhard Prof Dr | USE OF SPECIAL AMINES TO PREVENT NITROSAMINE FORMATION |
| FI79857C (en) * | 1988-07-12 | 1990-03-12 | Orion Yhtymae Oy | RENGOERINGSMEDELKOMPOSITION OCH DESS ANVAENDNING. |
| FR2795956B1 (en) * | 1999-07-06 | 2006-07-14 | Inst Evaluation Dermatophysiqu | COSMETIC COMPOSITION FOR IMPROVING SKIN ELASTICITY AND COMBATTING AGING |
| US8278359B2 (en) | 2005-02-25 | 2012-10-02 | Johnson & Johnson Consumer Companies, Inc. | Compositions containing amines and use thereof to treat acne or reduce the appearance of oil or pores on the skin |
| US20060193814A1 (en) | 2005-02-25 | 2006-08-31 | Eduardo Ruvolo | Compositions for the treatment of signs of aging |
| US8221046B2 (en) | 2005-02-25 | 2012-07-17 | Johnson & Johnson Consumer Companies, Inc. | Compositions containing amines and use thereof |
| AU2014274581B2 (en) * | 2005-02-25 | 2016-11-17 | Johnson & Johnson Consumer Inc. | Compositions containing amines and use thereof |
| AU2012201897B2 (en) * | 2005-02-25 | 2015-01-22 | Johnson & Johnson Consumer Inc. | Compositions containing amines and use thereof |
| US7547434B2 (en) | 2005-09-09 | 2009-06-16 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for mitigating skin irritation |
-
1974
- 1974-05-04 DE DE2421638A patent/DE2421638A1/en active Pending
-
1975
- 1975-04-07 NL NL7504116A patent/NL7504116A/en not_active Application Discontinuation
- 1975-04-07 SE SE7503963A patent/SE403045B/en unknown
- 1975-04-23 IT IT22636/75A patent/IT1037595B/en active
- 1975-04-29 GB GB17669/75A patent/GB1513053A/en not_active Expired
- 1975-04-30 BE BE155943A patent/BE828581A/en unknown
- 1975-04-30 FR FR7513667A patent/FR2269327B1/fr not_active Expired
- 1975-05-02 CH CH565475A patent/CH598816A5/xx not_active IP Right Cessation
- 1975-05-02 AT AT336675A patent/AT335622B/en not_active IP Right Cessation
- 1975-05-02 JP JP50052639A patent/JPS50154439A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0023978A3 (en) * | 1979-08-09 | 1982-01-13 | Basf Wyandotte Corporation | Harmless cosmetic and toiletry products and method of making same |
Also Published As
| Publication number | Publication date |
|---|---|
| SE403045B (en) | 1978-07-31 |
| BE828581A (en) | 1975-10-30 |
| JPS50154439A (en) | 1975-12-12 |
| SE7503963L (en) | 1975-11-05 |
| NL7504116A (en) | 1975-11-06 |
| IT1037595B (en) | 1979-11-20 |
| GB1513053A (en) | 1978-06-07 |
| FR2269327B1 (en) | 1979-06-08 |
| ATA336675A (en) | 1976-07-15 |
| AT335622B (en) | 1977-03-25 |
| CH598816A5 (en) | 1978-05-12 |
| FR2269327A1 (en) | 1975-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |