DE20023649U1 - Synergistic active agent combination of colostrum product, minerals and herbal component, useful as or in medicaments, foodstuffs, food supplements or cosmetics, e.g. for skin treatment - Google Patents

Abstract

A new active agent combination (I) for use in humans and animals comprises: (A) colostral milk products or extracts; (B) minerals and/or mineral salts; and (C) plant components and/or plant extracts. An independent claim is included for component (A) as a new active agent for use in humans and animals, provided that the colostrum is of human, ovine and/or caprine origin. ACTIVITY : Dermatological; antipsoriatic; antiinflammatory; antibacterial; antifungal; vulnerary; immunostimulant; antiallergic; analgesic. MECHANISM OF ACTION : Source of vitamins, minerals, growth factors, aminoacids, immunoglobulins, essential oils and other organic molecules (e.g. creatine and creatinine).

Description

The The invention relates to an active ingredient and more particularly to a combination of active ingredients for human and animal based on colostral milk products and / or colostral milk extracts.

colostrum or colostrum, also known as pre-or first milk, is a mostly by carotenes yellowish colored secretion of the female Mammary glands, that often already during Pregnancy, but especially in the first few days after Birth is formed. The colostrum is different from the mature breast milk especially by a higher one Content of proteins and vitamins, especially vitamins A and C, at about the same carbohydrate and slightly reduced fat content. Further has colostrum with fat drops laden leukocytes, the Kolostrum corpuscles or colostrum bodies on. The rich in immunoglobulins colostrum is after birth the first, for the first days of life important food of the newborn.

health and well-being in humans and animals are particularly recorded by the Depending on food or nutrients and alike of how the body prepared these substances. These substances can be in three different Drug groups are divided. The first shows the substances and Active ingredients contained in animal products. The second is the mineral group or the metal salts with their respective active ingredient content. The third may be the general plant area be assigned. Here is a large number of active ingredients known which are contained in the plants.

So far All three drug classes were processed and used alone.

First colostrum of bovine origin has been on the market for a few years now available. It has managed to get the valuable ingredients from colostral milk gently filter out. The dairy cows produce more colostral milk, as the calf needed. Part of the colostral milk is fed to the calves and the other part becomes filtered into the market. In the trade, the Kolostralmilchauszüge are in shape granules or as drinkable extracts.

The known Dead Sea salt products have been available only recently although already known to the Romans Bathing in the Dead Sea was known to be particularly curative. today The salt is extracted from the Dead Sea, purified and can be used as Salt bath, for example, be used at home. Dead Sea salt minerals are also used as raw materials for the external one Application used in cosmetics.

Plant Part and / or plant extracts have been known for millennia and are used in all health care applied.

Even though the mode of action of the three aforementioned drug groups in the single application very diverse and in many areas is still unexplored, the effectiveness could the three above-mentioned groups of active ingredients in an internal and external Application in particular for the entire skin area can be detected.

Generally It should be noted that the Diseases in the skin area increase drastically. If organs or Generally, the metabolism reveals problems is multiple in response also severely affected the skin. It then tries to skin problems by external application For example, to fix cosmetics, which symptoms, but not the Causes of problems are treated.

It has been for a while known that in all three active ingredient groups contain active substances, in particular can positively influence cell metabolism. That has effects in case of defects of the immune system as well as in allergic reactions, Skin diseases of various kinds, atopic dermatitis or psoriasis. Furthermore, all three groups of active substances are promoting Cell regeneration agents and therapeutics for the treatment of wounds, Sunburn, acne, in the tooth area, skin lesions, skin infections of all kinds, of pimples, of herpes, etc.

According to the invention there is now provided an active ingredient which is based on colostral milk products and / or colostral milk extracts of humans, sheep and / or goats. Used on its own or in the combination of active substances explained below, for example as a dietary supplement, food, cosmetic, pharmaceutical and / or as a medicament and as an additive in cosmetics, drinks, medicines, foodstuffs, nutritional supplements and in the pharmaceutical field, the active ingredient can be administered externally and / or be used internally in humans and animals. These colostral milk products and / or Kolostralmilchauszüge of humans, sheep and / or goats have significant differences compared to those of bovine origin and can be used effectively.

In particular, it has proven expedient to use colostral milk products and / or colostral milk extracts of humans, of sheep and / or goat in an amount of from 0.1 to 60 parts of a hundred as an additive, for example carrier mass ad 100 parts Ziegenkolostrum 0.1-60 parts plant extracts 0.1 - 17 parts Test extracts 0.1 - 2 parts

Likewise in parts between 0.1 - 60 von Hundert find after the invention Kolostralmilchprodukte and / or Kolostralmilchauszüge of humans, of sheep and / or goat use as food and dietary supplements Use. Which includes in particular refreshing and energy drinks and bars containing fibrous matter Nutritional and Fiber. As a dietary supplement For example, a tablet, powder or capsule form is preferred.

Examples

The The present invention further relates to a drug combination for the Human and veterinary area, containing colostral milk products and / or colostral milk extracts, too bovine and / or equine origin, in solid, liquid or pasty Form or else microencapsulated, in particular enclosed in liposomes; further comprising minerals and / or mineral salts, in particular recovered from the Dead Sea, and further comprising plant components and / or plant extracts, also in solid, liquid or pasty form or also microencapsulated, in particular used as a cosmetic, as a medicine, for prophylaxis and therapy for skin irritations of all kinds, used as food, as a dietary supplement or as a drink also as an additive for Cosmetics, for Medicines, foods, dietary supplements and beverages.

Especially with the mixture of colostral milk products and / or colostral milk extracts as animal products, of minerals and / or mineral salts as earth-active substances, especially because of the high mineral content preferred from the dead Obtained from the sea, and from plant components and / or plant extracts with the many herbal ingredients is an inventive combination of life-sustaining and healing substances have been found.

The The invention will be further explained with reference to an example of use:

The Basic components colostrum, minerals, especially Dead Sea Salt, and as a plant extract tea tree oil are each individually for themselves used in the skin area for skin irritations of various kinds Service. The active substances contained in the Kolostralmilch can, depending according to application form, taken internally as an extract or as Ointment externally be applied. The minerals agents used in various Skin diseases, especially psoriasis and neurodermatitis, are fed to humans through a salt bath over the skin. Not least Therefore, sick people travel to the Dead Sea for swimming. The already called universal remedy tea tree oil can after experimental studies and clinical studies of burns, Mouth and gingivitis, cuts as well as thrush infections are used. It is also known that colostrum ointment An excellent remedy for burns and within short Time the reddish Let the parts heal.

These previously used individually against burns and skin damage of any kind Components Colostrum, Dead Sea salt and tea tree oil can according to the invention in the form a single ointment consisting of 1% Dead Sea salt minerals, composed of colostrum powder and tea tree oil.

at the active ingredient combination according to the invention From these three groups of active substances arises an interaction of Groups that, if properly coordinated, have a synergy effect on each other trigger and thus both in an oral intake as well as an external Application a reinforced Healing effect, strengthened across from a single administration.

Out DE 296 23 125.8 and DE 196 19 990 It is known to filter out the active ingredients after decapazation of colostral milk from cattle and to make them ingestible for humans and animals. The filtered colostrum extract or colostrum powder is fixed in its composition per liter, except for small deviations in the substance content. Analysis of colostrum extract of bovine origin energy content 80.0 kj / 100g pH 6.16 osmolarity 418 mOsm / kg total protein 7.25 g / 100ml dry matter 8.36g / 100ml ash 0.68 g / 100ml lactose 0.2g / 100ml glucose 1.23 g / 100ml carbohydrates 3.8 g / 100ml fat <0.03g / 100ml VITAMINS Vitamin A <150 μg / 100ml Thiamine (vitamin B1) 69.6 μg / 100ml Riboflavin (Vit B2) 268.2 μg / 100ml Pyrodoxin (Vit. B6) 17.88 μg / 100ml Cobalamin (Vit. B12) 0.062 μg / 100ml folic acid 4.9 μg / 100ml vitamin C 270 μg / 100ml Cholecalciferol (D3) 0.28 μg / 100ml Tocopherol (Vit. E) 30 μg / 100ml ubiquinone 5.4 MINERALS Sodium (Na) 1344.7 mg / l Potassium (K) 1883.5 mg / l Calcium (Ca) 417.42 mg / l Magnesium (Mg) 163.72 mg / l Iron (Fe) 0.29 mg / l Copper (Cu) 0.06 mg / l Zinc (Zn) 0.06 mg / l Chrome (Cr) 0.01 mg / l Phosphorus (P) 498.0 mg / l Selenium (Se) 0.003 mg / NATURAL GROWTH FACTORS IGF-1 280 μg / l IGF-2 190 μg / l IGF-β 25 μg / l FREE AMINO ACIDS alanine 7.92 mg / l arginine 6.72 mg / l aspartic acid 3.19 mg / l beta-Alanine <0.32 mg / l beta-aminoisobutyric acid 1.24 mg / l citrulline 1.26 mg / l cystine <0.32 mg / l glutamine 8.77 mg / l glutamic acid 44.4 mg / l glycine 5.82 mg / l histidine 1.68 mg / l isoleucine 5.82 mg / l leucine 11.33 mg / l lysine 9.59 mg / l methionine 1.2 mg / l ornithine 0.64 mg / l phenylalanine 5.94 mg / l Phosphorus ethanolamine 32.84 mg / l Phosphorserin 10.87 mg / l proline 8.84 mg / l serine 6.05 mg / l taurine 138.0 mg / l threonine 3.73 mg / l tryptophan 7.32 mg / l tyrosine 3.91 mg / l valine 13.36 mg / l immunoglobulins IgG 60 g / l IgA 6 g / l IgM 12 g / l ORGANIC MOLECULES creatinine 44.7 mg / l creatine 165.1 mg / l

by virtue of The variety of its ingredients is the mode of action of colostrum only partially explored.

So far could be found that the Growth factors have a positive influence on cell metabolism take and increase the body's own Achieve immune defense.

The Immunoglobulins (antibodies ) support the immune system in prevention and defense against infections and are decisively anti-inflammatory.

The amino acids are vital protein building blocks for the Cell metabolism and cell regeneration.

All Active ingredients are water-soluble.

colostrum has special healing properties in terms of skin therapy as a protective substance Bacteria, germs and fungi and leads to a strengthening of the Skin tissue.

Minerals, especially Dead Sea salt, are already present in small amounts in the colostral milk, but are not important in terms of their importance in colostrum. At a Mi Due to its exceptionally high mineral content, Dead Sea salt also exerts its therapeutic effect on colostrum and, in particular, Dead Sea salt.

As with the colostrum, the analysis of, for example, Dead Sea salt is fixed except for small deviations per kg. Analysis of the Dead Sea salt CATIONS Sodium (Na) 74300 mg / kg Potassium (K) 162000 mg / kg ammonium 310 mg / kg magnesium 102000 mg / kg calcium 1760 mg / kg strontium 175 mg / kg manganese 6.8 mg / kg iron 45 mg / kg Anion fluoride 35 mg / kg chloride 557000 mg / kg bromide 5100 mg / kg iodide 14 mg / kg sulfate 460 mg / kg hydrogen phosphate 34 mg / kg bicarbonate 770 mg / kg carbonate 2430 mg / kg total 906440 mg / kg undissociated substances meta-silica 3450 mg / kg Dissolved solids 909890 mg / kg rest humidity

Metal salts, especially from the Dead Sea, are due to their Mineral components mostly external in humans or animals, for example, as a bath salt, as a shampoo, etc. used.

dead Sea salt is especially valuable for the skin area as it is rich is magnesium and potassium. Magnesium is known as an antiallergen an important building block for the structural elements of the skin and the enzymes responsible for the metabolism to control the skin. Potassium is an important moisture regulator for the Skin. Iodine has a disinfecting and healing effect. Chlorine and sodium are dissolved in water Electrolytes and play an important role in regulation of the body system of enzymes. External applications Dandruff, acne, eczema, psoriasis and atopic dermatitis as with other skin diseases and skin irritations. It is it has been proven that as a secondary phenomenon by the action of higher Salt concentrations on the skin increase the production of free amino acids becomes. In the foreground of the reactions of the skin metabolism stands however, the activation of proteolytic degradation processes of high molecular weight protein compounds. The resulting degradation products are peptides with hormone-like effects, so that ultimately the ions penetrating the skin to the inside of the organism can act, such as. on the vascular system, the smooth muscles, the digestive system and the vegetative hormonal System.

The third active ingredient component, plant components and plant extracts allowed by the large number on plants with their diverse Phytochemicals also countless variations for the new Drug combination. In particular, also because in many cases not only the extract of a plant, but extracts from different plants, in different high concentrations, can be used.

• Aloe Vera stärkt die Selbstheilung der Haut,
• Aprikosenpulver entfernt abgestorbene Hautzellen,
• Arnika fördert die Wundheilung,
• Avocadoöl ist beruhigend und reizlindernd,
• Eukalyptus, Geranium, Myrrhe sind antiseptisch und antibakteriell,
• Ginseng ist vitalisierend,
• Honig und Mandelöl sind entspannend und pflegend,
• Jojobaöl ist feuchtigkeitsspendend und nährend,
• Kamille und Lavendel sind entzündungshemmend,
• Nelkenöl ist schmerzlindernd,
• Pfefferminzöl ist kühlend und erfrischend,
• Sonnenblumenöl enthält viele Vitamine A, D, B und E und wirkt pflegend,
• Teebaumöl ist entwässernd und wirkt antibakteriell.

As the mixture of colostrum extracts and Dead Sea salt minerals is preferably used in the skin area, hereinafter, not by way of limitation, primarily and secondarily, skin-positive active substance-containing plants, plant components and / or plant extracts and their properties are listed tet, which are suitable for the combination of active substances according to the invention:

• Aloe Vera strengthens the self-healing of the skin,
• Apricot powder removes dead skin cells,
• Arnica promotes wound healing,
• Avocado oil is soothing and soothing,
• Eucalyptus, geranium, myrrh are antiseptic and antibacterial,
• Ginseng is vitalizing,
• Honey and almond oil are relaxing and nourishing,
• Jojoba oil is moisturizing and nourishing,
• Chamomile and lavender are anti-inflammatory,
• Clove oil is soothing,
• Peppermint oil is cooling and refreshing,
• Sunflower oil contains many vitamins A, D, B and E and has a nourishing,
• Tea tree oil is dehydrating and has an antibacterial effect.

It In this list, only the most important modes of action are indicated. Most extracts have a variety of ingredients that have further effects can.

colostrum usually works the strongest when ingested and is in external use its effect not so sustainable. The opposite is the effect of the dead Sea salt in external Application particularly beneficial to health. With direct application of Dead Sea salt to the skin of humans dissolve the horny and scaly parts. The minerals can be in penetrate the upper layers of the skin, leaving the skin sustainable excited, more receptive and more permeable becomes. This also means that the otherwise difficult recording the subtle colostral milk products and / or colostral milk extracts, if these over the skin should be absorbed by the inventive combination With Dead Sea salt is relieved and significantly improved. Also, an improved uptake of the active ingredients admixed plant extracts is achieved this way.

One Another example of such a synergy effect of the active ingredient combination according to the invention will be described below.

at An allergic to chamomile is often allergic. It is now proved that Mineral anti-allergic magnesium acts and an allergic reaction in an application with camomile counteracts. Thus, an application an active ingredient combination of colostrum, dead sea salt and camomile extracts also in a chamomile allergic allows. In external Application as an ointment, this combination of active ingredients has a calming effect and anti-inflammatory and facilitates the absorption of important substances into the skin.

It it should be noted that in particular in the combination and mixing of colostral milk extracts and / or products, minerals and / or mineral salts, in particular dead Sea salt minerals, and herbal extracts and / or plant constituents a new complete active ingredient system for the human and veterinary sector given is.

colostrum indicates as a natural product, its unique natural formulation In laboratories, it is unlikely that it will exactly be imitated, all vital nonessential and essential amino acids, immunoglobulins and natural growth factors together with vitamins, minerals and lactose and a variety of necessary Building and operating substance substances for the preservation and protection of the Life up.

minerals and / or mineral salts, especially Dead Sea salt as worldwide in the concentration of one-time mineral donors do not supplement or only in small measure in the Colostrum-containing minerals is yet another building block for health, the particular through the skin on the entire metabolism of the People can act.

Last is in the drug combination of the invention completed by herbal extracts and extracts and their diverse Modes of action also used.

Claims (5)

Active ingredient combination, comprising - colostral milk products and / or Kolostralmilchauszüge of humans, sheep and / or goat, - a mixture of minerals and / or mineral salts, in addition to the Kolostralmilchprodukte and / or Ko dissolvable milk extracts by ammonium, strontium, manganese, fluoride, chloride, bromide, iodide, sulphate, carbonates and meta-silicic acid and plant extracts. Active substance combination according to Claim 1, characterized that this contained in the mixture contained magnesium and / or magnesium Compounds each a minor proportion of the composition the drug combination have as the Kolostralmilchprodukte and / or Kolostralmilchauszüge. Active substance combination according to one or more of previous claims, characterized in that plant extracts are added in an amount of at least half of the Shares of Kolostralmilchprodukte and / or Kolostralmilchauszüge is. Active substance combination according to one or more of previous claims, characterized by their use in food and nutritional supplements. Active substance combination according to one or more of previous claims, characterized in that the Proportion of colostral milk products and / or colostral milk extracts between 0.1% and 60% of the food or dietary supplement.