DE19922310A1 - Pressure-tight vessel for conservation of tissues and organs for re- or transplantation has cooler, unit for enriching perfusion solution with oxygen and perfusion pump connected to receptacle for tissue or organ - Google Patents
Pressure-tight vessel for conservation of tissues and organs for re- or transplantation has cooler, unit for enriching perfusion solution with oxygen and perfusion pump connected to receptacle for tissue or organInfo
- Publication number
- DE19922310A1 DE19922310A1 DE19922310A DE19922310A DE19922310A1 DE 19922310 A1 DE19922310 A1 DE 19922310A1 DE 19922310 A DE19922310 A DE 19922310A DE 19922310 A DE19922310 A DE 19922310A DE 19922310 A1 DE19922310 A1 DE 19922310A1
- Authority
- DE
- Germany
- Prior art keywords
- perfusion
- tissue
- oxygen
- organ
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000010412 perfusion Effects 0.000 title claims abstract description 27
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 210000000056 organ Anatomy 0.000 title claims abstract description 18
- 239000001301 oxygen Substances 0.000 title claims abstract description 17
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 17
- 238000002054 transplantation Methods 0.000 title 1
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 239000007789 gas Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 238000007599 discharging Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 13
- 241000047428 Halter Species 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Zur Re- oder Transplantation vorgesehene Gewebe und Or gane müssen bis zum Zeitpunkt der Re- bzw. Transplanta tion so gelagert werden, daß eine Zellschädigung wei testgehend vermieden wird. Tissue and Or gane must be received by the time of the re or transplant tion are stored so that white cell damage is avoided on a test basis.
Aus der DE 195 27 734 A1 ist eine Vorrichtung bekannt, in der das Gewebe bzw. das Organ gekühlt und einer unter Druck stehenden Sauerstoffatmosphäre unterworfen wird.A device is known from DE 195 27 734 A1, in which the tissue or organ is cooled and one under Is subjected to pressurized oxygen atmosphere.
Es hat sich jedoch gezeigt, daß für eine Perfusion des Gewebes bzw. Organs mit einer geeigneten Perfusionslö sung zu sorgen ist.However, it has been shown that for a perfusion of the Tissue or organ with a suitable perfusion solution solution is to be taken care of.
Der Erfindung liegt die Aufgabe zugrunde, eine Vorrich tung zu schaffen, die dazu geeignet ist, für eine Re- oder Transplantation vorgesehenes Gewebe oder Organe über einen längeren Zeitraum zu erhalten.The invention has for its object a Vorrich to create equipment that is suitable for a or transplant intended tissue or organs over a longer period of time.
Erfindungsgemäß wird diese Aufgabe durch einen druckfe sten Behälter gelöst, der mit einem ersten Einlaß für eine Perfusionslösung, einem zweiten Einlaß für Sauer stoff, einer in dem Behälter angeordneten Einrichtung zum Anreichern der Perfusionslösung mit Sauerstoff, ei ner Perfusionspumpe, einer Einrichtung zum Aufnehmen des Gewebes oder Organs, einer Einrichtung zum Abführen der durch das Gewebe oder Organ geströmten Perfusionslösung und einer Einrichtung zum Kühlen des Innenraums des Be hälters.According to the invention, this object is achieved by a druckfe Most loosened container with a first inlet for a perfusion solution, a second inlet for Sauer substance, a device arranged in the container to enrich the perfusion solution with oxygen, ei ner perfusion pump, a device for receiving the Tissue or organ, a device for removing the perfusion solution flowing through the tissue or organ and a device for cooling the interior of the Be halters.
Ein bevorzugtes Ausführungsbeispiel zeichnet sich durch einen dritten Einlaß für Druckluft und einen Auslaß für das Kammergas aus.A preferred embodiment is characterized by a third inlet for compressed air and an outlet for the chamber gas.
Weiter wird vorgeschlagen, daß die Anreicherungseinrich tung als gegenüber dem Behälter druckdichter Kolben aus gebildet ist. Die Perfusionspumpe kann als eine übliche Infusionspumpe ausgebildet sein. It is also proposed that the enrichment device tion as a pressure-tight piston against the container is formed. The perfusion pump can be considered a common one Infusion pump be trained.
Weiter wird vorgeschlagen, daß die Kühleinrichtung durch Peltierelemente gebildet wird.It is further proposed that the cooling device through Peltier elements is formed.
Weitere Merkmale und Vorteile der Erfindung ergeben sich aus der nachfolgenden Beschreibung, in der ein Ausfüh rungsbeispiel der Erfindung anhand einer schematischen Darstellung wiedergegeben ist.Further features and advantages of the invention result from the following description, in which an exec Example of the invention based on a schematic Representation is reproduced.
Die Vorrichtung besteht aus einem druckfesten Behälter 10, der mit einem ersten Einlaß 12 zum Einbringen einer Perfusionslösung in den Behälter 10 und eine zweiten Einlaß 14 zum Einbringen von Sauerstoff versehen ist. In dem Behälter 10 ist eine Einrichtung 16 zum Anreichen der Perfusionslösung mit Sauerstoff angeordnet, die als gegenüber dem Behälter druckdicht abgeschlossener Kolben ausgebildet ist. Es ist in dem Behälter 10 ein Auslaß 30 zum Abführen von überschüssigem Sauerstoff aus der Ein richtung 16 vorgesehen.The device consists of a pressure-resistant container 10 , which is provided with a first inlet 12 for introducing a perfusion solution into the container 10 and a second inlet 14 for introducing oxygen. Arranged in the container 10 is a device 16 for enriching the perfusion solution with oxygen, which is designed as a piston which is closed in a pressure-tight manner with respect to the container. There is an outlet 30 in the container 10 for removing excess oxygen from a device 16 is provided.
Es ist ein Auslaß 30 zum Abführen von überschüssigem Sauerstoff aus den Behälter 10 vorgesehen.An outlet 30 is provided for removing excess oxygen from the container 10 .
In dem Behälter 10 ist weiter eine als Infusionspumpe ausgebildete Perfusionspumpe 18 sowie eine Einrichtung 20 zum Aufnehmen des Gewebes oder Organs sowie eine Ein richtung 22 zum Abführen der durch das Gewebe oder Orga ne strömenden Perfusionslösung versehen. Weiter ist eine Einrichtung 24 zum Kühlen des Innenraumbehälters 10 vor gesehen, die durch Peltierelemente gebildet wird.In the container 10 , a perfusion pump 18 designed as an infusion pump and a device 20 for receiving the tissue or organ and a device 22 for removing the perfusion solution flowing through the tissue or organ are further provided. Next, a device 24 for cooling the interior container 10 is seen before, which is formed by Peltier elements.
Bei der Verwendung der Vorrichtung wird das zu konser vierende Gewebe oder Organ in die Einrichtung 20 in den Behälter 10 gelegt. Der Behälter wird sodann druckdicht verschlossen. When using the device, the tissue or organ to be conserved is placed in the device 20 in the container 10 . The container is then closed pressure-tight.
Durch den ersten Einlaß 12 wird die Perfusionslösung in den Behälter 10 eingebracht und in der Anreicherungsein richtung 16, die über den zweiten Einlaß 14 mit Sauer stoff versorgt wird, mit Sauerstoff angereichert. Die mit Sauerstoff angereicherte Perfusionslösung wird so dann zu der Perfusionspumpe 18 geführt, von der die Per fusionslösung in das zu perfundierende Gewebe oder Organ in der Einrichtung 20 eingebracht wird. Die aus dem Or gan oder Gewebe wieder austretende Perfusionslösung wird von einer Einrichtung 22 aufgenommen, die mit einem Aus laß 32 zum Ausführen der Infusionslösung aus dem Behäl ter 10 versehen sein kann.Through the first inlet 12 , the perfusion solution is introduced into the container 10 and enriched with oxygen in the enrichment device 16 , which is supplied with oxygen via the second inlet 14 . The oxygen-enriched perfusion solution is then passed to the perfusion pump 18 , from which the perfusion solution is introduced into the tissue or organ to be perfused in the device 20 . The perfusion solution emerging from the organ or tissue is received by a device 22 which can be provided with an outlet 32 for executing the infusion solution from the container 10 .
Der zweite Einlaß 14 kann auch genutzt werden, um eine Sauerstoff-Überdruckatmosphäre zu erzeugen, vorzugsweise ist jedoch ein Dritter Einlaß 26 vorgesehen, der dazu dient, durch Einbringung von Druckluft in den Behälter 10 einen ausreichenden Überdruck zu schaffen. Weiter ist ein Auslaß 28 zum Auslassen des Gases in dem Behälter vorgesehen.The second inlet 14 can also be used to create an oxygen overpressure atmosphere, but a third inlet 26 is preferably provided, which serves to create a sufficient overpressure by introducing compressed air into the container 10 . There is also an outlet 28 for discharging the gas in the container.
Durch die Ausgestaltung des Behälters als Druckbehälter kann die Perfusionslösung in weit stärkerem Maße mit Sauerstoff angereichert werden, als dies bei einem Be hälter der Fall ist, in dem ein atmosphärischer Druck herrscht. Die Erfindung nutzt damit den Effekt der hyberbaren Oxygenisierung, indem die Diffusionsstrecke des Sauerstoffs in dem zu erhaltenden Gewebe deutlich verlängert wird.By designing the container as a pressure container can use the perfusion solution to a much greater extent Oxygen can be enriched when this occurs at a loading container is the case where an atmospheric pressure prevails. The invention thus uses the effect of hydrogenable oxygenation by the diffusion path of the oxygen in the tissue to be preserved is extended.
Claims (5)
- - einem ersten Einlaß (12) für eine Perfusionslösung,
- - einem zweiten Einlaß (14) für Sauerstoff,
- - einer in dem Behälter (10) angeordneten Einrichtung (16) zum Anreichern der Perfusionslösung mit Sauer stoff,
- - einer Perfusionspumpe (18),
- - einer Einrichtung (20) zum Aufnehmen des Gewebes oder Organs,
- - einer Einrichtung (22) zum Abführen der durch das Gewebe oder Organ geströmten Perfusionslösung und
- - einer Einrichtung (24) zum Kühlen des Innenraum des Behälters (10).
- - a first inlet ( 12 ) for a perfusion solution,
- - a second inlet ( 14 ) for oxygen,
- - A device ( 16 ) arranged in the container ( 10 ) for enriching the perfusion solution with oxygen,
- - a perfusion pump ( 18 ),
- - a device ( 20 ) for receiving the tissue or organ,
- - A device ( 22 ) for removing the perfusion solution flowing through the tissue or organ and
- - A device ( 24 ) for cooling the interior of the container ( 10 ).
- - einem dritten Einlaß (26) für Druckluft und
- - einem Auslaß (28) für das Kammergas,
- - einem Auslaß (30) für überschüssigen Sauerstoff aus der Anreicherungseinrichtung (16), und
- - einem Auslaß (32) für das Abführen von Perfusions flüssigkeit aus einer Einrichtung (22) aus einem Behälter (10) heraus.
- - A third inlet ( 26 ) for compressed air and
- - an outlet ( 28 ) for the chamber gas,
- - An outlet ( 30 ) for excess oxygen from the enrichment device ( 16 ), and
- - An outlet ( 32 ) for the removal of perfusion liquid from a device ( 22 ) out of a container ( 10 ).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19922310A DE19922310B4 (en) | 1999-05-14 | 1999-05-14 | Pressure-resistant container for the preservation of tissues and organs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19922310A DE19922310B4 (en) | 1999-05-14 | 1999-05-14 | Pressure-resistant container for the preservation of tissues and organs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19922310A1 true DE19922310A1 (en) | 2000-11-30 |
| DE19922310B4 DE19922310B4 (en) | 2006-01-19 |
Family
ID=7908106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19922310A Expired - Fee Related DE19922310B4 (en) | 1999-05-14 | 1999-05-14 | Pressure-resistant container for the preservation of tissues and organs |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE19922310B4 (en) |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6931864B2 (en) | 2000-12-07 | 2005-08-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cryostorage method and device |
| WO2006117658A3 (en) * | 2005-05-02 | 2007-01-04 | Lima Gaston Jeronimo Verri | Hyperbaric cryogenesis chamber |
| US7458285B2 (en) | 2003-06-26 | 2008-12-02 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Device for cryopreservation of samples and method for producing the device |
| US8685709B2 (en) | 2009-09-25 | 2014-04-01 | Board Of Regents Of The University Of Texas System | Fluidics based pulsatile perfusion preservation device and method |
| US8785116B2 (en) | 2012-08-10 | 2014-07-22 | Paragonix Technologies, Inc. | Methods for evaluating the suitability of an organ for transplant |
| US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US8835158B2 (en) | 2011-03-15 | 2014-09-16 | Paragonix Technologics, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
| US9426979B2 (en) | 2011-03-15 | 2016-08-30 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US9560846B2 (en) | 2012-08-10 | 2017-02-07 | Paragonix Technologies, Inc. | System for hypothermic transport of biological samples |
| US9867368B2 (en) | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US11166452B2 (en) | 2017-06-07 | 2021-11-09 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| USD1031028S1 (en) | 2022-09-08 | 2024-06-11 | Paragonix Technologies, Inc. | Tissue suspension adaptor |
| US12035708B2 (en) | 2011-03-15 | 2024-07-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12096765B1 (en) | 2011-03-15 | 2024-09-24 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12245585B2 (en) | 2019-06-11 | 2025-03-11 | Paragonix Technonogies, Inc. | Organ transport container with antiviral therapy |
| US12357533B2 (en) | 2023-08-25 | 2025-07-15 | Paragonix Technologies, Inc. | Systems and methods for maintaining organ pressure |
| USD1087382S1 (en) | 2025-01-30 | 2025-08-05 | Paragonix Technologies, Inc. | Device for transporting a biological sample |
| US12410408B2 (en) | 2024-02-02 | 2025-09-09 | Paragonix Technologies, Inc. | Method for hypothermic transport of biological samples |
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|---|---|---|---|---|
| DE4407863A1 (en) * | 1993-06-07 | 1994-12-08 | Mayer Berndt Priv Doz Dr Med | Method and device for the preservation of organs, extremities and tissue flaps |
| DE19527734A1 (en) * | 1995-07-28 | 1997-01-30 | Hubert Verhaag | Method and device for preserving tissues and organs, in particular transplant tissues and organs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3545225A (en) * | 1968-08-16 | 1970-12-08 | Swenko Research & Dev Inc | Apparatus for maintaining whole organs in a viable state |
-
1999
- 1999-05-14 DE DE19922310A patent/DE19922310B4/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4407863A1 (en) * | 1993-06-07 | 1994-12-08 | Mayer Berndt Priv Doz Dr Med | Method and device for the preservation of organs, extremities and tissue flaps |
| DE19527734A1 (en) * | 1995-07-28 | 1997-01-30 | Hubert Verhaag | Method and device for preserving tissues and organs, in particular transplant tissues and organs |
Cited By (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6931864B2 (en) | 2000-12-07 | 2005-08-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cryostorage method and device |
| US7458285B2 (en) | 2003-06-26 | 2008-12-02 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Device for cryopreservation of samples and method for producing the device |
| US9713328B2 (en) | 2005-05-02 | 2017-07-25 | Gaston Jeronimo Verri Lima | Hyperbaric criogenesis chambers |
| WO2006117658A3 (en) * | 2005-05-02 | 2007-01-04 | Lima Gaston Jeronimo Verri | Hyperbaric cryogenesis chamber |
| US8685709B2 (en) | 2009-09-25 | 2014-04-01 | Board Of Regents Of The University Of Texas System | Fluidics based pulsatile perfusion preservation device and method |
| US12245586B2 (en) | 2011-03-15 | 2025-03-11 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12035708B2 (en) | 2011-03-15 | 2024-07-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12369576B2 (en) | 2011-03-15 | 2025-07-29 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
| US9426979B2 (en) | 2011-03-15 | 2016-08-30 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US12342810B2 (en) | 2011-03-15 | 2025-07-01 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US9867368B2 (en) | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US9936689B2 (en) | 2011-03-15 | 2018-04-10 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
| US11089775B2 (en) | 2011-03-15 | 2021-08-17 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12279610B2 (en) | 2011-03-15 | 2025-04-22 | Paragonix Technonogies, Inc. | System for hypothermic transport of samples |
| US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12121023B1 (en) | 2011-03-15 | 2024-10-22 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12096765B1 (en) | 2011-03-15 | 2024-09-24 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12052985B2 (en) | 2011-03-15 | 2024-08-06 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US8835158B2 (en) | 2011-03-15 | 2014-09-16 | Paragonix Technologics, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US8785116B2 (en) | 2012-08-10 | 2014-07-22 | Paragonix Technologies, Inc. | Methods for evaluating the suitability of an organ for transplant |
| US9155297B2 (en) | 2012-08-10 | 2015-10-13 | Paragonix Technologies, Inc. | Methods and systems for assessing the suitability of an organ for transplant |
| US9560846B2 (en) | 2012-08-10 | 2017-02-07 | Paragonix Technologies, Inc. | System for hypothermic transport of biological samples |
| US11166452B2 (en) | 2017-06-07 | 2021-11-09 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US11659834B2 (en) | 2017-06-07 | 2023-05-30 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US12245585B2 (en) | 2019-06-11 | 2025-03-11 | Paragonix Technonogies, Inc. | Organ transport container with antiviral therapy |
| US12161110B2 (en) | 2020-01-31 | 2024-12-10 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US12178206B2 (en) | 2020-01-31 | 2024-12-31 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US12310357B2 (en) | 2020-01-31 | 2025-05-27 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| US12070029B2 (en) | 2020-01-31 | 2024-08-27 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| USD1031028S1 (en) | 2022-09-08 | 2024-06-11 | Paragonix Technologies, Inc. | Tissue suspension adaptor |
| US12357533B2 (en) | 2023-08-25 | 2025-07-15 | Paragonix Technologies, Inc. | Systems and methods for maintaining organ pressure |
| US12485064B2 (en) | 2023-08-25 | 2025-12-02 | Paragonix Technologies, Inc. | Systems and methods for measuring oxygen concentration for lung preservation |
| US12410408B2 (en) | 2024-02-02 | 2025-09-09 | Paragonix Technologies, Inc. | Method for hypothermic transport of biological samples |
| USD1087382S1 (en) | 2025-01-30 | 2025-08-05 | Paragonix Technologies, Inc. | Device for transporting a biological sample |
Also Published As
| Publication number | Publication date |
|---|---|
| DE19922310B4 (en) | 2006-01-19 |
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