DE19882538T1 - Verfahren zur Isomerisierung von Tilidin Derivaten davon - Google Patents
Verfahren zur Isomerisierung von Tilidin Derivaten davonInfo
- Publication number
- DE19882538T1 DE19882538T1 DE19882538T DE19882538T DE19882538T1 DE 19882538 T1 DE19882538 T1 DE 19882538T1 DE 19882538 T DE19882538 T DE 19882538T DE 19882538 T DE19882538 T DE 19882538T DE 19882538 T1 DE19882538 T1 DE 19882538T1
- Authority
- DE
- Germany
- Prior art keywords
- tilidine
- cis
- trans
- tilidine base
- values
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WDEFBBTXULIOBB-WBVHZDCISA-N dextilidine Chemical class C=1C=CC=CC=1[C@@]1(C(=O)OCC)CCC=C[C@H]1N(C)C WDEFBBTXULIOBB-WBVHZDCISA-N 0.000 title abstract 3
- 238000006317 isomerization reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- WDEFBBTXULIOBB-NVXWUHKLSA-N ethyl (1R,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate Chemical compound C=1C=CC=CC=1[C@]1(C(=O)OCC)CCC=C[C@H]1N(C)C WDEFBBTXULIOBB-NVXWUHKLSA-N 0.000 abstract 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 abstract 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/36—Racemisation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE970517 | 1997-07-14 | ||
| IE970542 | 1997-07-25 | ||
| PCT/IE1998/000052 WO1999003821A2 (en) | 1997-07-14 | 1998-06-26 | Process for isomerisation of tilidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19882538T1 true DE19882538T1 (de) | 2000-06-21 |
Family
ID=26320073
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1000013T Pending DE1000013T1 (de) | 1997-07-14 | 1998-06-26 | Verfahren zur isomerisierung von tilidin |
| DE19882538T Withdrawn DE19882538T1 (de) | 1997-07-14 | 1998-06-26 | Verfahren zur Isomerisierung von Tilidin Derivaten davon |
| DE69805415T Expired - Lifetime DE69805415T2 (de) | 1997-07-14 | 1998-06-26 | Verfahren zur isomerisierung von tilidin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1000013T Pending DE1000013T1 (de) | 1997-07-14 | 1998-06-26 | Verfahren zur isomerisierung von tilidin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69805415T Expired - Lifetime DE69805415T2 (de) | 1997-07-14 | 1998-06-26 | Verfahren zur isomerisierung von tilidin |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1000013B1 (de) |
| AT (1) | ATE217609T1 (de) |
| AU (1) | AU728810B2 (de) |
| DE (3) | DE1000013T1 (de) |
| IE (1) | IE980513A1 (de) |
| WO (1) | WO1999003821A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201322935D0 (en) * | 2013-12-23 | 2014-02-12 | Randox Lab Ltd | Tilidine immunodetection |
| WO2017021445A1 (en) * | 2015-08-06 | 2017-02-09 | Siegfried Pharmachemikalien Minden Gmbh | Tilidine isomerization and crystallization process |
| AU2020311579A1 (en) | 2019-07-05 | 2022-02-03 | Iomx Therapeutics Ag | Antibodies binding IgC2 of IGSF11 (VSIG3) and uses thereof |
| EP4175668A1 (de) | 2020-07-06 | 2023-05-10 | iOmx Therapeutics AG | Igv von igsf11 (vsig3) bindende antikörper und verwendungen davon |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5978M (de) * | 1965-11-19 | 1968-04-22 | ||
| DE1518959B1 (de) * | 1965-11-19 | 1970-03-26 | Goedecke Ag | Verfahren zur Herstellung von basisch substituierten Cyclohexenen |
| US3679732A (en) * | 1969-04-17 | 1972-07-25 | Warner Lambert Co | Process for obtaining 3-trans-dimethylamino-4-phenyl-4-trans-carbethoxy-{66 {11 -cyclohexene |
-
1998
- 1998-06-26 AT AT98932480T patent/ATE217609T1/de not_active IP Right Cessation
- 1998-06-26 EP EP98932480A patent/EP1000013B1/de not_active Expired - Lifetime
- 1998-06-26 DE DE1000013T patent/DE1000013T1/de active Pending
- 1998-06-26 IE IE980513A patent/IE980513A1/en not_active IP Right Cessation
- 1998-06-26 WO PCT/IE1998/000052 patent/WO1999003821A2/en not_active Ceased
- 1998-06-26 AU AU82384/98A patent/AU728810B2/en not_active Ceased
- 1998-06-26 DE DE19882538T patent/DE19882538T1/de not_active Withdrawn
- 1998-06-26 DE DE69805415T patent/DE69805415T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE217609T1 (de) | 2002-06-15 |
| WO1999003821A3 (en) | 1999-05-20 |
| IE980513A1 (en) | 1999-10-20 |
| AU8238498A (en) | 1999-02-10 |
| EP1000013A2 (de) | 2000-05-17 |
| EP1000013B1 (de) | 2002-05-15 |
| AU728810B2 (en) | 2001-01-18 |
| DE69805415D1 (de) | 2002-06-20 |
| WO1999003821A2 (en) | 1999-01-28 |
| DE1000013T1 (de) | 2000-08-31 |
| DE69805415T2 (de) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |