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DE19803292A1 - Robot for dosing liquids in amounts measured in microliters - Google Patents

Robot for dosing liquids in amounts measured in microliters

Info

Publication number
DE19803292A1
DE19803292A1 DE1998103292 DE19803292A DE19803292A1 DE 19803292 A1 DE19803292 A1 DE 19803292A1 DE 1998103292 DE1998103292 DE 1998103292 DE 19803292 A DE19803292 A DE 19803292A DE 19803292 A1 DE19803292 A1 DE 19803292A1
Authority
DE
Germany
Prior art keywords
robot
microliters
liquids
amounts measured
dosing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1998103292
Other languages
German (de)
Inventor
Joerg Frey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE1998103292 priority Critical patent/DE19803292A1/en
Publication of DE19803292A1 publication Critical patent/DE19803292A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The robot for dosing reactants, solutions and other liquids in amounts measure in microliters uses a printer head cartridge for chemical analysis and synthesis.

Description

Die Erfindung betrifft eine Vorrichtung entsprechend dem Oberbegriff des Anspruchs 1.The invention relates to a device according to the preamble of Claim 1.

Um chemische Analysen und Synthesen im Mikroliterbereich durchführen zu können, ist ein entsprechendes Dosiersystem für Flüssigkeiten nötig.To perform chemical analysis and synthesis in the microliter range too an appropriate dosing system for liquids is necessary.

In der Regel werden hierfür Motorbüretten oder ähnliche mechanische Systeme verwendet. Der Tintenstrahldrucker ist ein gängiges Verfahren um Schriftzeichen oder Grafiken auf Papier zu drucken. Die Druckkopfpatrone wird hierzu mit Tinte verschiedener Farbe befüllt.As a rule, motor burettes or similar mechanical ones are used for this Systems used. The inkjet printer is a common process around Print characters or graphics on paper. The printhead cartridge is filled with ink of different colors.

Aufgabe der Erfindung ist es, unter Verwendung einer Druckkopfpatrone aus einem Tintenstrahldrucker, einen Roboter für chemische Analysen und Synthesen aufzubauen.The object of the invention is to use a print head cartridge an inkjet printer, a robot for chemical analysis and To build syntheses.

Diese Aufgabe wird durch eine Maschine mit den Merkmalen des Anspruchs 1 gelöst.This task is accomplished by a machine with the features of the claim 1 solved.

Druckkopfpatronen eines Tintenstrahldruckers sind hoch präzise Dosiersysteme für Tinten. Sie lassen aber auch das Dosieren von anderen verdampfbaren Flüssigkeiten zu. Dies kann dazu benutzt werden, um Maßlösungen oder chemische Reagenzien im Mikrolitermaßstab zu dosieren.Print cartridges in an inkjet printer are highly precise Dosing systems for inks. But you also leave the dosing of others evaporable liquids. This can be used to Microliter-scale solutions or chemical reagents dose.

Der Roboter besitzt eine Druckkopfpatrone zur Dosierung von Flüssigkeiten in einer Halterung, welche über Reaktionsgefäße und Mikrotiterplatten eine Bewegung in x und y-Richtung ausführen kann. Der zu messende Parameter wird durch bekannte Verfahren wie Leitfähigkeitsmessung und potentiometrische Verfahren ermittelt. Dazu sind Elektroden an der Druckkopfpatrone angebracht, die beim Absenken in die Reaktionsgefäße eintauchen. The robot has a print head cartridge for dosing liquids in a holder, which is a reaction tube and microtiter plates Can perform movement in the x and y direction. The parameter to be measured is by known methods such as conductivity measurement and potentiometric method determined. There are electrodes on the Printhead cartridge attached when lowering into the reaction vessels immerse yourself.  

Der beschriebene Roboter kann so chemische Reihenanalysen im Mikroliterbereich durchführen. Es wird somit eine deutlich höhere Genauigkeit bei sinkendem Material und Zeitaufwand erreicht. Die Einführung des Mikrolitermaßstabs senkt den Chemikalienverbrauch beträchtlich. Standardisierte Maßlösungen halten länger, dies steigert die Reproduzierbarkeit der Ergebnisse in Reihenuntersuchungen.The robot described can thus perform chemical series analyzes in the Carry out microliter range. It will be a much higher one Accuracy achieved with decreasing material and time expenditure. The Introduction of the microliter scale reduces chemical consumption considerably. Standardized measurement solutions last longer, which increases them Reproducibility of the results in serial examinations.

Beispiele für die Realisation sind in einigen Skizzen dargestellt und anschließend näher beschrieben.Examples of the realization are shown in some sketches and then described in more detail.

Skizze 1Sketch 1

Ein Roboter zur Durchführung von Analysen und Synthesen im Mikrolitermaßstab unter Verwendung eines Druckkopfes aus einem Tintenstrahldrucker.A robot to carry out analyzes and syntheses in Microliter scale using a printhead from one Inkjet printer.

Skizze 2Sketch 2 Aufbau zur manuellen AnwendungSetup for manual application

Um Reihenanalysen im Mikrolitermaßstab durchführen zu können, wird ein Analyseroboter verwendet. Über eine Grundplatte bewegt sich die Druckkopfpatrone in x und y-Richtung. Sie ist so befestigt, daß sie in der Halterung abgesenkt werden kann. Dies ist erforderlich um die Elektroden in die Reaktionsgefäße einzutauchen.To be able to carry out series analyzes on a microliter scale, a Analysis robot used. The moves over a base plate Printhead cartridge in x and y direction. It is attached so that it is in the Bracket can be lowered. This is necessary to put the electrodes in immerse the reaction vessels.

Claims (1)

Roboter zum Dosieren von Reagenzien, Maßlösungen und sonstigen Flüssigkeiten im Mikrolitermaßstab, gekennzeichnet durch die Verwendung einer Druckkopfpatrone für Anwendungen der Analytik und Synthese.
Titrationen unter Verwendung einer Druckkopfpatrone zur Dosierung der Maßlösung.Robots for dosing reagents, standard solutions and other liquids on a microliter scale, characterized by the use of a printhead cartridge for analytical and synthesis applications.
Titrations using a printhead cartridge to dose the standard solution.
DE1998103292 1998-01-29 1998-01-29 Robot for dosing liquids in amounts measured in microliters Withdrawn DE19803292A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1998103292 DE19803292A1 (en) 1998-01-29 1998-01-29 Robot for dosing liquids in amounts measured in microliters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1998103292 DE19803292A1 (en) 1998-01-29 1998-01-29 Robot for dosing liquids in amounts measured in microliters

Publications (1)

Publication Number Publication Date
DE19803292A1 true DE19803292A1 (en) 1999-08-05

Family

ID=7855933

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998103292 Withdrawn DE19803292A1 (en) 1998-01-29 1998-01-29 Robot for dosing liquids in amounts measured in microliters

Country Status (1)

Country Link
DE (1) DE19803292A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20018628U1 (en) * 2000-11-01 2002-03-14 EVOTEC BioSystems AG, 22525 Hamburg Sample delivery device
WO2002081088A3 (en) * 2001-04-05 2003-03-13 Morphochem Ag Komb Chemie Device for automatically dispensing microscopic amounts of liquid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4024545A1 (en) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Metered delivery of biochemical analytical soln., esp. reagent
EP0556566A1 (en) * 1992-01-30 1993-08-25 Roche Diagnostics GmbH Apparatus for the metered supply of reagents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4024545A1 (en) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Metered delivery of biochemical analytical soln., esp. reagent
EP0556566A1 (en) * 1992-01-30 1993-08-25 Roche Diagnostics GmbH Apparatus for the metered supply of reagents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20018628U1 (en) * 2000-11-01 2002-03-14 EVOTEC BioSystems AG, 22525 Hamburg Sample delivery device
WO2002081088A3 (en) * 2001-04-05 2003-03-13 Morphochem Ag Komb Chemie Device for automatically dispensing microscopic amounts of liquid

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8139 Disposal/non-payment of the annual fee