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DE19580261D2 - Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction - Google Patents

Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction

Info

Publication number
DE19580261D2
DE19580261D2 DE19580261T DE19580261T DE19580261D2 DE 19580261 D2 DE19580261 D2 DE 19580261D2 DE 19580261 T DE19580261 T DE 19580261T DE 19580261 T DE19580261 T DE 19580261T DE 19580261 D2 DE19580261 D2 DE 19580261D2
Authority
DE
Germany
Prior art keywords
drugs
prevention
treatment
pharmaceutical preparations
endothelial dysfunction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE19580261T
Other languages
German (de)
Inventor
Eike Albrecht Prof Dr Me Noack
Georg Dr Rer Nat Kojda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Puren Pharma GmbH and Co KG
Original Assignee
Isis Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharma GmbH filed Critical Isis Pharma GmbH
Priority to DE19580261T priority Critical patent/DE19580261D2/en
Application granted granted Critical
Publication of DE19580261D2 publication Critical patent/DE19580261D2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19580261T 1994-03-30 1995-03-28 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction Expired - Lifetime DE19580261D2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19580261T DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4410997A DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunctions
DE19580261T DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction
PCT/DE1995/000421 WO1995026725A1 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction

Publications (1)

Publication Number Publication Date
DE19580261D2 true DE19580261D2 (en) 1997-05-28

Family

ID=6514213

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4410997A Withdrawn DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunctions
DE19580261T Expired - Lifetime DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunction

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4410997A Withdrawn DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical preparations and drugs for the prevention and treatment of endothelial dysfunctions

Country Status (19)

Country Link
EP (1) EP0752858A1 (en)
JP (1) JPH09510979A (en)
CN (1) CN1150387A (en)
BG (1) BG63073B1 (en)
CA (1) CA2186783A1 (en)
CZ (1) CZ283696A3 (en)
DE (2) DE4410997A1 (en)
EE (1) EE9600139A (en)
FI (1) FI963883A0 (en)
HU (1) HU220165B (en)
IS (1) IS4365A (en)
LT (1) LT4310B (en)
LV (1) LV11666B (en)
MX (1) MX9604434A (en)
NO (1) NO964102D0 (en)
PL (1) PL316528A1 (en)
SI (1) SI9520047A (en)
SK (1) SK121896A3 (en)
WO (1) WO1995026725A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
DE19604361C2 (en) * 1996-02-07 1999-01-14 Sanol Arznei Schwarz Gmbh Use of gas-tight primary packaging for pharmaceutical compositions
DE19654895C2 (en) * 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh Detection method
DE19726812A1 (en) * 1997-06-25 1999-01-07 Isis Pharma Gmbh New nitryl-oxy-methyl derivatives derived from pentaerythritol
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
ZA989356B (en) * 1997-10-16 1998-11-16 Isis Pharma Gmbh Pharmaceutical preparations
DE19745622A1 (en) * 1997-10-16 1999-04-22 Isis Pharma Gmbh New nitric acid ester derivatives of pentaerythritol
CA2306216C (en) * 1997-10-17 2011-06-07 Eurogene Limited The use of inhibitors of the renin-angiotensin system for the treatment of cachexia and wasting
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
AU5503199A (en) * 1998-06-24 2000-01-10 Alpharma-Isis Gmbh And Co. Kg Analytic substrates and antioxidative agents
US6465463B1 (en) 1999-09-08 2002-10-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
CA2386954C (en) 1999-10-29 2011-12-13 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
ES2258365B1 (en) * 2003-10-03 2007-12-01 Lacer, S.A. DERIVATIVES OF DISULFIDE, SULFIDE, SULFOXIDE AND SULFONE OF CYCLING SUGARS AND THEIR USES.
US20100144864A1 (en) * 2007-04-05 2010-06-10 Ironwood Pharmaceuticals, Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
MX2012013774A (en) * 2010-05-27 2012-12-17 Merck Sharp & Dohme SOLUBLE CYCLING GUANILATE ACTIVATORS.
RU2467748C1 (en) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" 3-(2,2,2-trimethylhydrazinium) propionate derivative - 3-(2,2,2-trimethylhydrazinium) potassium propionate glycinate exhibiting endothelioprotective activity
JP5360939B2 (en) * 2011-09-28 2013-12-04 国立大学法人徳島大学 A therapeutic agent for arteriosclerosis comprising a nitrosonifedipine derivative as an active ingredient

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR984523A (en) * 1949-02-10 1951-07-06 Trinitro-triethanolamine phosphate and method of preparation
DE1695897C3 (en) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-acyl-sydnonimines, their salts, processes for their preparation and medicaments containing these compounds
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
DE2532124C3 (en) * 1975-07-18 1979-04-19 Cassella Ag, 6000 Frankfurt Process for the production of 4-amino-morpholine
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE2623800C3 (en) * 1976-05-28 1978-11-23 Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf Super-saturated aqueous isosorbide dinitrate solution, manufacturing process and use
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
DE2903927C2 (en) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Process for the selective production of isosorbide-5-nitrate
DE3028873C2 (en) * 1980-07-30 1983-10-27 Boehringer Mannheim Gmbh, 6800 Mannheim Process for the preparation of 1,4 to 3,6-dianhydro-D-glucitol-5-nitrate (isosorbide-5-nitrate)
DE3102947A1 (en) * 1981-01-29 1982-09-02 Heinrich Mack Nachf., 7918 Illertissen METHOD FOR PRODUCING ISOSORBIDE 5-NITRATE
FR2500835A1 (en) * 1981-02-27 1982-09-03 Poudres & Explosifs Ste Nale PROCESS FOR THE SYNTHESIS OF MONONITRATES OF ISOSORBIDE
DE3117612A1 (en) * 1981-05-05 1982-11-25 Cassella Ag, 6000 Frankfurt METHOD FOR PRODUCING ISOSORBIDE 5-NITRATE
DE3124410A1 (en) * 1981-06-22 1983-01-05 Heinrich Mack Nachf., 7918 Illertissen METHOD FOR PRODUCING ISOSORBIDE-2-NITRATE
JPS5910513A (en) * 1982-07-12 1984-01-20 Nitto Electric Ind Co Ltd Pharmaceutical preparation of drug
DE3325652A1 (en) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Solid, stable pharmaceutical formulations containing isosorbide 5-mononitrate, and process for the production thereof
DE3328094A1 (en) * 1983-08-04 1985-02-21 H. Trommsdorff GmbH & Co, 5110 Alsdorf Desensitised pharmaceutical formulation of explosive nitric acid esters
DE3479800D1 (en) * 1983-11-25 1989-10-26 Toshin Chemical Co A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof
DD244980A1 (en) * 1985-12-18 1987-04-22 Isis Chemie Zwickau Veb PROCESS FOR PREPARING N-MORPHOLINOAMINOACETONITRILE AND ITS HYDROCHLORIDE
DD293492A5 (en) * 1987-11-26 1991-09-05 Isis-Chemie Gmbh,De METHOD FOR THE PRODUCTION OF A GLYCEROLTRINITRATE DRUG FILM WITH SIMILARLY DELAYED DRUG RELEASE
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4007705C1 (en) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4038203A1 (en) * 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmaceutical spray-prepn. for admin. of nitrate(s) - esp. for treatment of cardiovascular, disorders, asthma, migraine and colic
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Also Published As

Publication number Publication date
FI963883A7 (en) 1996-09-27
SK121896A3 (en) 1998-10-07
NO964102L (en) 1996-09-27
HUT76676A (en) 1997-10-28
AU2134595A (en) 1995-10-23
CN1150387A (en) 1997-05-21
CA2186783A1 (en) 1995-10-12
DE4410997A1 (en) 1995-10-26
BG63073B1 (en) 2001-03-30
LT4310B (en) 1998-03-25
NO964102D0 (en) 1996-09-27
LV11666B (en) 1997-06-20
JPH09510979A (en) 1997-11-04
IS4365A (en) 1996-09-25
LT96148A (en) 1997-12-29
HU220165B (en) 2001-11-28
EE9600139A (en) 1997-04-15
MX9604434A (en) 1997-12-31
CZ283696A3 (en) 1998-03-18
BG100930A (en) 1997-07-31
HU9602671D0 (en) 1996-11-28
AU698359B2 (en) 1998-10-29
LV11666A (en) 1997-02-20
WO1995026725A1 (en) 1995-10-12
PL316528A1 (en) 1997-01-20
SI9520047A (en) 1997-06-30
FI963883L (en) 1996-09-27
FI963883A0 (en) 1996-09-27
EP0752858A1 (en) 1997-01-15

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: ALPHARMA-ISIS GMBH & CO. KG, 40764 LANGENFELD, DE

8130 Withdrawal