DE19528575A1 - Treatment of e.g. psoriasis vulgaris or acne - using Azadirachta indica extract by oral, external or rectal admin., also effective against neuro-dermatitis and Crohn's disease - Google Patents
Treatment of e.g. psoriasis vulgaris or acne - using Azadirachta indica extract by oral, external or rectal admin., also effective against neuro-dermatitis and Crohn's diseaseInfo
- Publication number
- DE19528575A1 DE19528575A1 DE1995128575 DE19528575A DE19528575A1 DE 19528575 A1 DE19528575 A1 DE 19528575A1 DE 1995128575 DE1995128575 DE 1995128575 DE 19528575 A DE19528575 A DE 19528575A DE 19528575 A1 DE19528575 A1 DE 19528575A1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- treatment
- crohn
- acne
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000284 extract Substances 0.000 title claims abstract description 15
- 201000004681 Psoriasis Diseases 0.000 title claims abstract description 14
- 240000005343 Azadirachta indica Species 0.000 title claims abstract description 10
- 235000013500 Melia azadirachta Nutrition 0.000 title claims abstract description 10
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 5
- 208000011231 Crohn disease Diseases 0.000 title claims abstract description 5
- 201000009053 Neurodermatitis Diseases 0.000 title claims abstract description 5
- 206010000496 acne Diseases 0.000 title claims abstract description 5
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- -1 plasters Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 241000792859 Enema Species 0.000 claims 1
- 239000007920 enema Substances 0.000 claims 1
- 229940095399 enema Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 230000035876 healing Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Die Erfindung betrifft die Verwendung eines Extraktes des Neembaumes (Azadirachta indica) vorzugsweise aus den Blättern zur Behandlung von verschiedenen Hauterkrankungen, insbesonde re zur Behandlung von Psoriasis, Neurodermitis, Akne, Morbus Crohn und Psoriasis arthropathica.The invention relates to the use of an extract of the Neem tree (Azadirachta indica) preferably from the leaves for the treatment of various skin diseases, in particular re for the treatment of psoriasis, neurodermatitis, acne, disease Crohn and psoriasis arthropathica.
Der tropische Neembaum ist als Lieferant zahlreicher Heil mittel in der Volksmedizin bekannt. Beispielsweise wird im Canadian Journal of Botany 68,1, 1990, 1-11(1) eine ausführ liche Darstellung der Eigenschaften und Anwendungsbereiche des Neembaumes beschrieben. Nach "Römpp" werden Rindenextrakte in Haut- und Mundpflegemitteln verwendet. Viele chemische Bestandteile aus Azadirachta indica wurden isoliert und charakterisiert, vgl. ((1) a.a.O.).The tropical neem tree is a supplier of numerous salvation well known in folk medicine. For example, in Canadian Journal of Botany 68, 1990, 1-11 (1) Liche representation of the properties and areas of application Neembaumes described. After "Römpp" bark extracts are in Skin and oral care products used. Many chemical Components from Azadirachta indica have been isolated and characterized, cf. ((1) op. Cit.).
Im Journal of Research in Ayurveda und Siddha 1 [1]; 1980; 52-58 wird berichtet, daß eine aus dem Samenöl von Azadirachta indica isolierbare Verbindung, nämlich Nimbidin, an einem einzigen Patienten zur Behandlung der Psoriasis eingesetzt wurde.In the Journal of Research in Ayurveda and Siddha 1 [1]; 1980; 52-58 it is reported that one from Azadirachta indica isolable compound, namely nimbidin, on one used only to treat psoriasis has been.
Die Psoriasis ist eine chronische Hauterkrankung, die den Befallenen größte Unannehmlichkeiten verursacht. Die Ursachen der Psoriasis sind weitgehend ungeklärt und eine kausative Behandlung ist bislang nicht bekannt. Die bislang eingesetzte Behandlung und die verwendeten Präparate bewirken lediglich eine vorübergehende Erscheinungsfreiheit.Psoriasis is a chronic skin disease that affects the Affected greatest inconvenience. The reasons Psoriasis are largely unexplained and causative Treatment is not yet known. The one used so far Treatment and the preparations used only have an effect a temporary freedom of expression.
Es besteht daher ein größtes allgemeines Interesse an neuen Verfahren und Präparaten, die zur Behandlung der Psoriasis und der anderen vorhingenannten Erkrankungen im Vergleich zu den bisherigen Methoden vorteilhafter eingesetzt werden können.There is therefore a great general interest in new ones Processes and preparations used to treat psoriasis and of the other aforementioned diseases compared to the previous methods can be used more advantageously.
Es wurde nunmehr überraschenderweise gefunden, daß ein Extrakt vorzugsweise aus den Blättern des Neembaumes, insbesondere zur Behandlung der Psoriasis vulgaris vorteilhaft eingesetzt werden kann, wodurch diese zum Abheilen gebracht werden kann oder zumindest eine wesentliche Verbesserung des Hautzustandes erreicht wird. Der erfindungsgemäß verwendete Extrakt, vorzugsweise aus den Blättern wird nach bekannten Verfahren erhalten, vgl. z. B. Journal of Pharmacology 35, 1991, 1-24.It has now surprisingly been found that an extract preferably from the leaves of the neem tree, especially for Treatment of psoriasis vulgaris advantageously used can be, which can be brought to healing or at least a significant improvement in skin condition is achieved. The extract used according to the invention, the leaves are preferably made by known methods received, cf. e.g. B. Journal of Pharmacology 35, 1991, 1-24.
Der getrocknete Extrakt wird zur Verabreichung an die Patien ten in Gelatinekapseln, beispielsweise 100 mg pro Kapsel, abgefüllt und die Kapseln beispielsweise drei mal täglich oral eingenommen.The dried extract is used for administration to the patient in gelatin capsules, for example 100 mg per capsule, filled and the capsules orally three times a day, for example ingested.
Der Verabreichungszeitraum hängt von dem Zustand und der feststellbaren Wirkung ab, liegt jedoch üblicherweise bei ca. 70 Tagen.The period of administration depends on the condition and the detectable effect, but is usually approx. 70 days.
Der Extrakt kann aber auch nach üblichen in der pharmazeuti schen Technologie bekannten Verfahren in jede gewünschte Darreichungsform überführt werden. Beispielsweise sind zu nennen Tabletten, Pflaster, Cremes, Lotionen, Suppositorien, Salben und Duschmittel.However, the extract can also be prepared in the usual way in the pharmaceutical known technology in any desired Dosage form to be transferred. For example, are too name tablets, plasters, creams, lotions, suppositories, Ointments and shower products.
Patient: M.R.
Krankheit: Psoriasis vulgaris, ausgedehnter
Befund
Dauer der Erkrankung: 6,5 Jahre
Dosis: 3 mal täglich 100 mg
Dauer der Behandlung: 70 Tage
Erfolg mittlere LinderungPatient: MR
Disease: psoriasis vulgaris, extensive finding
Duration of the disease: 6.5 years
Dose: 100 mg 3 times a day
Treatment duration: 70 days
Success medium relief
Patient: W.H.
Krankheit: Psoriasis vulgaris, mittelschwerer
Befund
Dauer der Erkrankung: 10 Jahre, rezidivierend
Dosis: 3 mal täglich 100 mg
Dauer der Behandlung: 70 Tage
Erfolg: ca. 90%-ige AbheilungPatient: WH
Disease: psoriasis vulgaris, moderate finding
Duration of the disease: 10 years, recurrent
Dose: 100 mg 3 times a day
Treatment duration: 70 days
Success: approx. 90% healing
Patient: K.K.
Krankheit: Psoriasis vulgaris, ausgedehnter
Befund
Dauer der Erkrankung: 20 Jahre
Dosis: 3 mal täglich 100 mg
Dauer der Behandlung: 70 Tage
Erfolg: 50%-ige AbheilungPatient: KK
Disease: psoriasis vulgaris, extensive finding
Duration of the disease: 20 years
Dose: 100 mg 3 times a day
Treatment duration: 70 days
Success: 50% healing
Patient: G.H.
Krankheit: Psoriasis vulgaris
Dauer der Erkrankung: 20 Jahre
Dosis: 3 mal täglich 100 mg
Dauer der Behandlung: 70 Tage
Erfolg: 80%-ige AbheilungPatient: GH
Disease: psoriasis vulgaris
Duration of the disease: 20 years
Dose: 100 mg 3 times a day
Treatment duration: 70 days
Success: 80% healing
Patient: R.O.
Krankheit: Psoriasis vulgaris
Dauer der Erkrankung: 13 Jahre
Dosis: 3 mal täglich 100 mg
Dauer der Behandlung: 70 Tage
Erfolg: 50%-ige AbheilungPatient: RO
Disease: psoriasis vulgaris
Duration of the disease: 13 years
Dose: 100 mg 3 times a day
Treatment duration: 70 days
Success: 50% healing
Wie die vorstehenden Untersuchungen an Patienten zeigen, führt die erfindungsgemäße Verwendung des Blattextraktes zu einer deutlichen Besserung des klinischen Befundes, auch bei schwersten Ausprägungen der Erkrankung.As the above studies on patients show, leads the inventive use of the leaf extract to a significant improvement in the clinical findings, also with most severe forms of the disease.
In gleicher Weise geeignet sind die Extrakte zur Behandlung der Akne vulgaris, Neurodermitis, Morbus Crohn und Psoriasis arthropathica.The extracts are equally suitable for treatment acne vulgaris, neurodermatitis, Crohn's disease and psoriasis arthropathica.
Weitere Vorteile des Extraktes sind die ökonomisch und ökologisch vorteilhafte Gewinnung sowie die praktische Nebenwirkungsfreiheit des Präparates.Further advantages of the extract are the economical and ecologically advantageous extraction as well as practical Freedom from side effects of the preparation.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995128575 DE19528575A1 (en) | 1995-08-03 | 1995-08-03 | Treatment of e.g. psoriasis vulgaris or acne - using Azadirachta indica extract by oral, external or rectal admin., also effective against neuro-dermatitis and Crohn's disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995128575 DE19528575A1 (en) | 1995-08-03 | 1995-08-03 | Treatment of e.g. psoriasis vulgaris or acne - using Azadirachta indica extract by oral, external or rectal admin., also effective against neuro-dermatitis and Crohn's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19528575A1 true DE19528575A1 (en) | 1997-02-06 |
Family
ID=7768623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1995128575 Withdrawn DE19528575A1 (en) | 1995-08-03 | 1995-08-03 | Treatment of e.g. psoriasis vulgaris or acne - using Azadirachta indica extract by oral, external or rectal admin., also effective against neuro-dermatitis and Crohn's disease |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE19528575A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2905862A1 (en) * | 2006-09-20 | 2008-03-21 | Oreal | Preparing a topical composition useful to treat oily skin, seborrheic dermatitis, acne, black spots and comedones, comprises percolation of fluid under pressure through vegetable substances containing antibacterial agents |
| US8545901B2 (en) | 2008-10-24 | 2013-10-01 | Conopco Inc. | Topical composition comprising extracts of A. indica and M. charantia or S. indicum |
-
1995
- 1995-08-03 DE DE1995128575 patent/DE19528575A1/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2905862A1 (en) * | 2006-09-20 | 2008-03-21 | Oreal | Preparing a topical composition useful to treat oily skin, seborrheic dermatitis, acne, black spots and comedones, comprises percolation of fluid under pressure through vegetable substances containing antibacterial agents |
| US8545901B2 (en) | 2008-10-24 | 2013-10-01 | Conopco Inc. | Topical composition comprising extracts of A. indica and M. charantia or S. indicum |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8139 | Disposal/non-payment of the annual fee |