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DE1618935A1 - N-mercaptophenyl fatty acid amides and processes for their preparation - Google Patents

N-mercaptophenyl fatty acid amides and processes for their preparation

Info

Publication number
DE1618935A1
DE1618935A1 DE19671618935 DE1618935A DE1618935A1 DE 1618935 A1 DE1618935 A1 DE 1618935A1 DE 19671618935 DE19671618935 DE 19671618935 DE 1618935 A DE1618935 A DE 1618935A DE 1618935 A1 DE1618935 A1 DE 1618935A1
Authority
DE
Germany
Prior art keywords
fatty acid
formula
amine
reacted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19671618935
Other languages
German (de)
Inventor
Toshitsugu Fukumaru
Hideaki Fukushima
Noritaka Hamma
Hiroshi Nakatani
Katsuyuku Toki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of DE1618935A1 publication Critical patent/DE1618935A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)

Claims (1)

18183351818335 Patent an sprächePatent to speak Λ-i Verbindungen der allgemeinen Formel Λ-i compounds of the general formula R-COJiR-COJi in der R ein verzweigter oder geradkettiger, gesättigter oder ungesättigter, synthetischer oder natürlicher aliphatischer Kohlenwasserstoffrest mit 13 bis 25 Kohlenstoffatomen mit oder ohne Hydroxylgruppen und R1 Wasserstoff, eine Methyl-, Äthyl-, Propyl- (normal oder iso) ; oder Butylgruppe (normal, iso oder tertiär) bedeutet, wobei sich die Gruppe -SR' in Ortho-, meta- oder para-Stellung befindet.in which R is a branched or straight-chain, saturated or unsaturated, synthetic or natural aliphatic hydrocarbon radical with 13 to 25 carbon atoms with or without hydroxyl groups and R 1 is hydrogen, methyl, ethyl, propyl (normal or iso) ; or butyl group (normal, iso or tertiary), the group -SR 'being in the ortho, meta or para position. 2» Pharmazeutische Zubereitung mit einem Gehalt einer Verbindung nach Anspruch 1, als wesentlichen aktiven Wirk- . stoff.2 »Pharmaceutical preparation containing one compound according to claim 1, as an essential active agent. material. 3. Verfahren zur Herstellung von Verbindungen nach Anspruch 1, dadurch gekennzeichnet, daß man entweder eine Fettsäure der Formel RCOOH mit einem Amin'der Formel3. A method for the preparation of compounds according to claim 1, characterized in that either a fatty acid of the formula RCOOH with an amine of the formula / V/ V .in Gegenwart'oder Abwesenheit eines Dehydratisierungsmittel umsetzt, oder daß man ein Fettsäurehalogenid äer Formel RCOX, in der J, ein Halogenatom ist, mit dem Amin in Gegenwart eines basischen Kondensationsmittels umsetzt,Reacts in the presence or absence of a dehydrating agent, or that a fatty acid halide of the formula RCOX, in which J, is a halogen atom, is reacted with the amine in the presence of a basic condensing agent, Von* Deu'^'V-r. ?-;e~'?-'~t ohnie jede From * Deu '^' Vr. ? -; e ~ '? -' ~ t without any Gev;3hr lxr/j.- . ' : /...··:XtIft voll : - ;■"---Gev; 3hr lxr / j.-. ': /...··: Xt If t full : -; ■ "--- Unterlegen, ilia zur iutomedianisdienInferior, ilia to iutomedianisdien Wiedergabe nidit geeignet sind. 109838/1712 VPlayback are not suitable. 109838/1712 V BAD ORfGiJ^BAD ORfGiJ ^ j, 1618335j, 1618335 oder daß man einen niedrigen Allylester öder1 ein G-lyceri-i. einer Fettsäure der Formel RCOOH mit dem AmIn in Gegenwart oder Abwesenheit eines Lösungsmittels and eines Kondensation.-sniitt.els umsetzt, oder daß man ein gemischtes Anhydrid einer Fettsäure der Formelor in that a low allyl barren 1, a G-lyceri-i. a fatty acid of the formula RCOOH is reacted with the amine in the presence or absence of a solvent and a condensation solvent, or a mixed anhydride of a fatty acid of the formula ECC.
S14CO-
ECC.
S 14 CO-
in der B' ' eine Alkyl- oder Halogenalkylgpappe mit *■ bis Kohlenstoffatomen ist, mit dem AmIn In (regenwart eines basischen Kondensationskatalysators umsetztt wobei In den Formeln· S und-E* die genannte Bedeutung haben.wherein B '' is an alkyl or Halogenalkylgpappe with * ■ up to carbon atoms, with the amine in (rain waiting a basic condensation catalyst is reacted with t In the formulas · S and E * have the meanings mentioned. Vom Deutschen Patentamt ohne Jed·From the German Patent Office without Jed Gewähr hergGslci:ve Ah?iiz'ul von .Guarantee hergGslci: v e Ah? Iiz'ul of. Unterlagen} die zur iotcaicdianisdieü: .Documents} the iotcaicdianisdieü:. Wiedergabe niÄt geeignet sind.Playback are not suitable. BAD ORIGINALBATH ORIGINAL
DE19671618935 1966-08-12 1967-08-11 N-mercaptophenyl fatty acid amides and processes for their preparation Pending DE1618935A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP5317066 1966-08-12
JP67467 1966-12-27
JP67567 1966-12-27
JP56867 1966-12-28
JP4355167 1967-07-05
JP4355267 1967-07-05

Publications (1)

Publication Number Publication Date
DE1618935A1 true DE1618935A1 (en) 1971-09-16

Family

ID=27547536

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19671618935 Pending DE1618935A1 (en) 1966-08-12 1967-08-11 N-mercaptophenyl fatty acid amides and processes for their preparation

Country Status (8)

Country Link
US (1) US3576830A (en)
BE (1) BE702623A (en)
CH (1) CH508607A (en)
DE (1) DE1618935A1 (en)
FI (1) FI47882C (en)
FR (2) FR7586M (en)
GB (1) GB1201631A (en)
NL (1) NL6711100A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268082A (en) * 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
EP0022614B1 (en) * 1979-06-13 1983-09-21 National Research Development Corporation A process for electrochemical additions to alkenes
JP2894445B2 (en) * 1997-02-12 1999-05-24 日本たばこ産業株式会社 Compounds effective as CETP activity inhibitors
CN1289467C (en) * 2002-08-30 2006-12-13 日本烟草产业株式会社 Dibenzylamine compound and its medicinal use
KR20050110017A (en) * 2003-03-17 2005-11-22 니뽄 다바코 산교 가부시키가이샤 Method for increasing the oral bioavailability of s-'2-(''1-(2-ethylbutyl)cyclohexyl!carbonyl!amino)phenyl!-2-methylpropanethioate
MXPA05009848A (en) * 2003-03-17 2005-12-06 Japan Tobacco Inc Pharmaceutical compositions of cetp inhibitors.
TWI494102B (en) * 2003-05-02 2015-08-01 Japan Tobacco Inc Combination comprising s-(2-(((1-(2-ethylbutyl)cyclohexyl)carbonyl)amino)phenyl)2-methylpropanethioate and an hmg coa reductase inhibitor
CN113466396B (en) * 2021-06-23 2024-09-17 山东省产品质量检验研究院 Method for detecting migration quantity of plasticizer in skin contact material
WO2025024685A2 (en) * 2023-07-27 2025-01-30 Thomas Jefferson University Inhibitors of cib1 interactions and methods of use

Also Published As

Publication number Publication date
FI47882C (en) 1974-04-10
CH508607A (en) 1971-06-15
FI47882B (en) 1974-01-02
BE702623A (en) 1968-02-12
US3576830A (en) 1971-04-27
FR7586M (en) 1970-01-12
GB1201631A (en) 1970-08-12
NL6711100A (en) 1968-02-13
FR1565354A (en) 1969-05-02

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