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DE122006000056I2 - 2-Fluorarabinofuranosylpurinnukleoside - Google Patents

2-Fluorarabinofuranosylpurinnukleoside

Info

Publication number
DE122006000056I2
DE122006000056I2 DE19863687397 DE3687397C DE122006000056I2 DE 122006000056 I2 DE122006000056 I2 DE 122006000056I2 DE 19863687397 DE19863687397 DE 19863687397 DE 3687397 C DE3687397 C DE 3687397C DE 122006000056 I2 DE122006000056 I2 DE 122006000056I2
Authority
DE
Germany
Prior art keywords
fluorarabinofuranosylpurinnukleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE19863687397
Other languages
English (en)
Other versions
DE3687397T2 (de
DE3687397D1 (de
DE122006000056I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of DE122006000056I1 publication Critical patent/DE122006000056I1/de
Publication of DE122006000056I2 publication Critical patent/DE122006000056I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE19863687397 1985-10-18 1986-10-17 2-Fluorarabinofuranosylpurinnukleoside Active DE122006000056I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/789,072 US4751221A (en) 1985-10-18 1985-10-18 2-fluoro-arabinofuranosyl purine nucleosides

Publications (2)

Publication Number Publication Date
DE122006000056I1 DE122006000056I1 (de) 2007-01-18
DE122006000056I2 true DE122006000056I2 (de) 2007-05-31

Family

ID=25146507

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8686114412T Expired - Fee Related DE3687397T2 (de) 1985-10-18 1986-10-17 2-fluorarabinofuranosylpurinnukleoside.
DE19863687397 Active DE122006000056I2 (de) 1985-10-18 1986-10-17 2-Fluorarabinofuranosylpurinnukleoside

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8686114412T Expired - Fee Related DE3687397T2 (de) 1985-10-18 1986-10-17 2-fluorarabinofuranosylpurinnukleoside.

Country Status (5)

Country Link
US (2) US4751221A (de)
EP (1) EP0219829B1 (de)
JP (1) JPH0723395B2 (de)
CA (1) CA1271192A (de)
DE (2) DE3687397T2 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5106837A (en) * 1988-03-16 1992-04-21 The Scripps Research Institute Adenosine derivatives with therapeutic activity
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PT86377B (pt) * 1986-12-24 1990-11-20 Lilly Co Eli Processo para a preparacao de conjugados de imunoglobulinas com um difluoronucleosideo acilado
US5175274A (en) * 1987-04-03 1992-12-29 Burroughs Wellcome Co. Therapeutic nucleosides
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
AU626296B2 (en) * 1988-03-16 1992-07-30 Scripps Clinic And Research Foundation Substituted adenine derivatives useful as therapeutic agents
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
US5026688A (en) * 1988-10-31 1991-06-25 Administrators Of The Tulane Educational Fund Novel AZT analogs
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
US5034518A (en) * 1989-05-23 1991-07-23 Southern Research Institute 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
GB8920534D0 (en) * 1989-09-11 1989-10-25 Wellcome Found Antiviral compounds
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5681941A (en) * 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5420115A (en) * 1990-09-10 1995-05-30 Burroughs Wellcome Co. Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
AU1254892A (en) * 1990-12-18 1992-07-22 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-"up" fluorinated 2''-deoxy-arabinofuranosylpurines
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
WO1993023058A1 (en) * 1992-05-19 1993-11-25 The Scripps Research Institute Use of 2-halo adenine derivatives as therapeutic agents against chronic myelogenous leukemia
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
PL299413A1 (en) * 1992-06-22 1994-03-07 Lilly Co Eli Stereoselective glycozilation process effected by means o anions
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US6491905B1 (en) * 1993-09-14 2002-12-10 The Uab Research Foundation Recombinant bacterial cells for delivery of PNP to tumor cells
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
US6232463B1 (en) 1997-10-09 2001-05-15 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
JPH11217396A (ja) * 1998-01-30 1999-08-10 Ajinomoto Co Inc ヌクレオシド誘導体の製造方法
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
MXPA02008075A (es) * 2000-02-18 2005-06-06 Southern Res Inst Metodos para sintetizar 2-cloro -9-(2 -deoxi-2 -fluoro -beta- arabinofura-nosil)- 9h- purin- 6-amina.
AU2005234681B2 (en) * 2000-02-18 2008-11-20 Southern Research Institute Methods for Synthesizing 2-Chloro-9-(2-Deoxy-2-Fluoro-Beta-D-Arabinofuranosyl)-9H-Purin-6-Amine
EP1412369B1 (de) 2001-08-02 2008-05-07 Ilex Oncology, Inc. Verfahren zur herstellung von purinnukleosiden
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US7022680B2 (en) * 2002-05-30 2006-04-04 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
WO2004029025A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
EP1551386A4 (de) * 2002-09-27 2009-03-25 Bioenvision Inc Verfahren und zusammensetzungen zur behandlung von lupus mit clofarabin
EP1460082A1 (de) * 2003-03-19 2004-09-22 Heidelberg Pharma Holding GmbH Phospholipidester von clofarabin-derivate
US7273600B2 (en) * 2003-04-25 2007-09-25 University Of Southern California [18F]-furanosylpurine derivatives and uses thereof
JP4658807B2 (ja) * 2003-10-24 2011-03-23 ヤマサ醤油株式会社 α−１−リン酸化２−デオキシ−２−フルオロアラビノシド及び２’−デオキシ−２’−フルオロ−β−Ｄ−アラビノヌクレオシドの製造法
CN101076536A (zh) * 2004-07-30 2007-11-21 药华医药股份有限公司 β－核苷的立体选择性合成
US7485716B2 (en) * 2005-05-02 2009-02-03 Pharmaessentia Corp. Stereoselective synthesis of β-nucleosides
WO2007027564A2 (en) * 2005-08-29 2007-03-08 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
KR20090021346A (ko) * 2006-06-06 2009-03-03 안티브 테라퓨틱스 인크. 트리메부틴 및 ｎ-데스메틸 트리메부틴 염
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
AU2008323923A1 (en) * 2007-11-06 2009-05-14 Pharmaessentia Corporation Novel synthesis of beta-nucleosides
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
ES2341215B1 (es) * 2008-12-15 2011-04-26 Consejo Superior De Investigaciones Cientificas (Csic) (51%) Nucleosidos modificados para el tratamiento de infecciones por leishmania.
ES2341603B1 (es) * 2008-12-15 2011-04-28 Consejo Superior De Investigaciones Cientificas (Csic) (51%) Derivados de nucleosidos para el tratamiento de infecciones por leishmania.
BRPI0922508A8 (pt) 2008-12-23 2016-01-19 Pharmasset Inc Análogos de nucleosídeo
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
AU2009329872B2 (en) 2008-12-23 2016-07-07 Gilead Pharmasset Llc Synthesis of purine nucleosides
CN102438588B (zh) * 2009-03-23 2015-04-01 埃姆比特生物科学公司 使用联合治疗法治疗疾病的方法
EA201190269A1 (ru) * 2009-05-12 2012-07-30 Саузерн Рисерч Инститьют 2'-фторарабинонуклеозиды и их применение
WO2011003018A2 (en) * 2009-07-01 2011-01-06 Cornell University Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof
US9011817B2 (en) * 2009-09-03 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Compounds and methods of making compounds
CA2794671C (en) 2010-03-31 2018-05-01 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN104193790A (zh) * 2014-09-25 2014-12-10 王庚禹 一种甲酰腺嘌呤化合物
PL3661937T3 (pl) 2017-08-01 2021-12-20 Gilead Sciences, Inc. Formy krystaliczne ((s)-((((2r,5r)-5-(6-amino-9h-puryn-9-ylo)-4-fluoro-2,5-dihydrofuran-2-ylo)oksy)metylo)(fenoksy)fosforylo)-l-alaninianu etylu (gs-9131) do leczenia zakażeń wirusowych

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides

Also Published As

Publication number Publication date
DE3687397T2 (de) 1993-07-01
JPS62161797A (ja) 1987-07-17
DE3687397D1 (de) 1993-02-11
EP0219829A2 (de) 1987-04-29
EP0219829B1 (de) 1992-12-30
CA1271192A (en) 1990-07-03
EP0219829A3 (en) 1988-05-04
JPH0723395B2 (ja) 1995-03-15
DE122006000056I1 (de) 2007-01-18
US4751221A (en) 1988-06-14
US4918179A (en) 1990-04-17

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