DE1165392B - Substances containing vitamins as admixture to animal feed - Google Patents

Description

FEDERAL REPUBLIC OF GERMANY

GERMAN

PATENT OFFICE

EDITORIAL

Boarding school Class: A 23 k

Number:
File number:
Registration date:
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German KL: 53 g -4/04

L 38090IV a / 53 g
February 1, 1961
March 12, 1964

Complementary feed containing vitamins, for the purpose of their shelf life by mixing vitamin solutions made with corn flour are known.

It is also no longer new to use free-flowing powder-form feedstuffs that contain vitamin-active substances in a water-soluble phase in which they are dissolved, or in the case of that the vitamin-active substances are not soluble in water, are dispersed. The water soluble Phase in which the vitamin-active substances are distributed must be such that these substances remain evenly distributed in the interior of the particles during the drying of the water-soluble phase; on the On the other hand, it must not prevent the adsorption of the vitamin-active substances in the digestive tract Belittle the animal. Accordingly, it is mainly the various hydrophilic colloids in an aqueous solution which have been found suitable for this purpose. Gelatin is so far in has been used widely since it can be used to form colloidal aqueous solutions in which the vitamin-active substances are easily soluble or easily dispersible. These solutions are even at a high water content capable of forming a gel before draining the water. Here will be easily formed particles in which the vitamin-active substances are evenly distributed inside them and in which the distribution is maintained during the drying of the particles.

In contrast to gelatin, zein swells only to a small extent with water, in which it does is practically insoluble even at higher temperatures. However, the zein forms clear viscous solutions with lower aliphatic alcohols, such as. B. ethanol, propanols or butanols with or without Addition of other suspending agents, such as. B. water, ketones or chlorinated hydrocarbons. This solution is particularly suitable as a carrier for the distribution of the preparation containing vitamins in dissolved or dispersed form and is able to form a solid mass in the dry state the dissolved or dispersed material is included.

It has been suggested to use zein in some cases along with a large amount of rosin acid for coating cereal crops, e.g. Vitaminized rice, to protect the vitamin contained in the grain or to form a coating that is able to obtain a white pigment on the surface. However, these processes involve the formation of particles which are smaller than the vitamins-containing substances as admixture
to feed

Applicant:

L0vens Kemiske Factory Ved A. Kongsted,

Ballerup (Denmark)

Representative:

Dipl.-Chem. Dr. A. Ullrich

and Dipl.-Chem. Dr. T. Ullrich, patent attorneys,

Heidelberg, Poststr. 30th

Named as inventor:
Erik Jespersen, Copenhagen

Claimed priority:

Great Britain of February 4, 1960 (No. 4065) Great Britain of February 10, 1960 (No. 4758)

Cereal grains, incompatible and not applicable for the production of additives that the

Contains vitamins in high concentrations (cf.

U.S. Patents 2,775,521 and 2,831,770).

There are also pharmaceutical preparations with sustained release of one contained therein Drug in the digestive tract by dissolving this drug in a solution of zein in isopropyl alcohol, squeezing out the paste obtained, drying and crushing the resulting paste Fibers and incorporating them into gelatian capsules. So it was suggested on this way to manufacture barbituric acid supplements that fairly slow the drug during the Release through the digestive tract (see US Pat. No. 2,895,880).

As far as it is known admixtures to feed, they have the disadvantage that their vitamin effect either during the incorporation into a feed or during the subsequent storage decreases.

The subject of the invention is the use of dry, giant-shaped, zein-coated vitamins of groups A, D ₂ , D _? and the natural or synthetic K vitamins, substances containing their salts or esters as admixtures to animal feed. According to an advantageous embodiment of the invention, the admixture contains antioxidants, such as. B. Para-aminophenol,

409 538/167

Claims (1)

ϊ 165 392 3 4 Butylated hydroxytoluene or 6-ethoxy-1,2-dihydro mixed so that the mixture contained 1000 IU / g. One 2,2,4-trimethylquinoline. This gives a prepa- another mixture was made from a commercially available vitrate of greater durability. The zein can also be made amine A preparation in which the vitamin Contain substances that are capable of having the properties present in particles resulting from a mixture of charge To change Zeins, such as B. Carbohydrates such as 5 tine and carbohydrates existed uiad such Glucose or maltose, higher glycols or their amount of white bran added to the mixture Esters, fatty acids or their esters or esters containing 100 IU / g. Both mixes were made Phthalic acid or similar acids. Left to stand for 24 hours at 20 ° C and then with The compositions according to the invention stand out in contrast to such an amount of a chick feed mixture mixes with the known admixtures to io that the final mixes contained 10 IU / g; Feed through an improved shelf life. the final mixes then became pills or The following table shows experimental data - beads with a diameter of 5 to 6 mm give in which the loss of A vitamin effectively- squeezed. ability of admixtures with the same grain size To determine the stability of vitamin A and the same original contents of A-Vit-15 in these mixtures, the spheres of both amines were sealed once with gelatin in a known manner and mixtures were sealed with zein for 2 months at 40 ° C of the invention are filled with one another, whereupon their vitamin A content is paid off. One of the gelatin supplements is on was true. It was found that the loss was bought on the market, the others, especially vitamin A in the mixture that the inventor made for the experiment and contained the preparation according to the invention, was 20%, while the additions of antioxidants were used The loss in the other mixture is based on the information in the table. The storage was amounted to 50%
done in two sections; it became example 2 first
a premix with micro additions of mineral substances prepared, which then took a month ² 5 A solution of 3 kg of zein and 300 g for a long time at 20 ° C in closed containers. Diethyl phthalate in a mixture of 2.6 kg was preserved, whereupon the finished feed ethanol and 600 g of distilled water are made, mixture by incorporating this premix into the solution was at 6O ⁰ C for 4 hours on a an ordinary well-known feed mix brought to a water bath to ensure a completely clear solution. was asked. The resulting mixture was to obtain 3o solution, whereupon 300 g of a commercially available vitamin Pills or pellets formed, and the samples were added to amine-A concentrate in which were kept at 40 ° C for one month. ^Every gram of one million IU of vitamin A and 1 mg Contained 2,6-ditertiary butyl-p-cresol. With help of a The results of a high-speed stirrer, an emulsion was Loss 35, in which the particles of the vitamin A concentration Commercially available, gelatin-coated protuberance had a maximum dimension of 4 μ. the duct (1% BHT) 50% emulsion was cooled to 40 ° C, whereupon it was converted into _. , ... ^,. a normal spray drying device dried Special preparation coated with gelatine _net ^ _n J ₆ with 5% p-aminophenoI 40% 40 The product obtained had a very low spe- with 1% 6-ethoxy-1,2-dihydro-2,2,4-tricifisches weight. After mixing with 3 parts methylquinoline 30% lactose but such properties were achieved _. that it is suitable for admixture with animal feed Zempräparat _was with 1% oBHT 20% 45 Example 3 with 5% p-aminophenol 10% with 1% 6-ethoxy-1,2-dihydro-2,2,4-tri- 30 g of a vitamin concentrate, consisting of vit- methylquinoline 10% amine A acetate dissolved in soy oil and 1 million IU Containing vitamin Α per gram, 3 g Example 1 ⁵ ° 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline ge P mixes. The mixture was as a disperse phase in 30 g of a commercially available vitamin A concentrate with an emulsion used in which the homogeneous a content of 1 million international units phase from a solution of 300 g of zein and 30 g of di- (IU) of vitamin A per gram and 1 mg of 2,6-diethyl phthalate in 180 g of ethanol and 60 g of distilled tertiary butyl-p-cresol (»butylated hydroxytoluene ₅₅ water. The emulsion was made with the help of a = BHT «) per gram were generated with a solution of high speed stirrer that used 300 g of zein and 30 g of diethyl phthalate in one was until the maximum dimension of the particles Mixture of 180 g of ethanol and 60 g of water in the disperse phase was 4 μ. The thereby formed 60 ° C mixed. The resulting mixture was strongly emulsion in a 1 mm thick layer on plates stirred until the phase containing the vitamin 60 is poured and dried at 40 ° C in a stream of air,
was uniformly dispersed in the solution. The one with it The emulsion formed was in a 1 mm thick layer.
Poured onto plates and at 40 ° C in an air stream dried and ground. The content of vitamin A 1. Use of dry, giant-shaped, of the ground product was 6 ₅ coated with zein with 80,000 IU / g, vitamins of groups A, averages. D ₂ and D ₃ , natural or synthetic The product was made with such an amount of K vitamins, containing their salts or esters Wheat bran with a moisture content of 17% substances as an admixture to feed. 5 6 2. Use of an admixture based on an-sorbitols, expediently monoesters, or fatty words 1, characterized by the content of an acid with 7 to 9 carbon atoms in the or more antioxidants such as carbon chain. p-aminophenol, butylated hydroxytoluene or 6-eth- oxy-l ^ -dihydro-l ^^ - trimethylquinoline. 5 Considered publications: 3. Use of an admixture according to French patent specification No. 1 056 114; Proverbs 1 and 2, characterized by the content of British Patent No. 704 064; to zein-modifying substances, such as. B. U.S. Patents Nos. 2,508,477, 2,775,521, Polyethylene glycols of higher fatty acid esters of 2,831,770, 2,895,880. 409 538/167 3.64 ® Bundesdruckerei Berlin