DE10299017I2 - Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. - Google Patents
Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid.Info
- Publication number
- DE10299017I2 DE10299017I2 DE2002199017 DE10299017C DE10299017I2 DE 10299017 I2 DE10299017 I2 DE 10299017I2 DE 2002199017 DE2002199017 DE 2002199017 DE 10299017 C DE10299017 C DE 10299017C DE 10299017 I2 DE10299017 I2 DE 10299017I2
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- hepatitis
- amino acid
- acid sequence
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 208000002672 hepatitis B Diseases 0.000 title 1
- 239000000178 monomer Substances 0.000 abstract 7
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 3
- 208000005252 hepatitis A Diseases 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87108914 | 1987-06-22 | ||
| EP87108915 | 1987-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE10299017I1 DE10299017I1 (de) | 2002-08-29 |
| DE10299017I2 true DE10299017I2 (de) | 2005-05-25 |
Family
ID=26108175
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3856496T Expired - Lifetime DE3856496T2 (de) | 1987-06-22 | 1988-06-22 | Hepatitis-B-Oberflächenantigen enthaltendes Peptid |
| DE2002199017 Active DE10299017I2 (de) | 1987-06-22 | 1988-06-22 | Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3856496T Expired - Lifetime DE3856496T2 (de) | 1987-06-22 | 1988-06-22 | Hepatitis-B-Oberflächenantigen enthaltendes Peptid |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US6022543A (de) |
| EP (2) | EP0300213A1 (de) |
| JP (2) | JP2758184B2 (de) |
| KR (1) | KR890701742A (de) |
| AT (1) | ATE207535T1 (de) |
| CA (1) | CA1341074C (de) |
| DE (2) | DE3856496T2 (de) |
| ES (1) | ES2167304T3 (de) |
| IL (2) | IL86833A0 (de) |
| WO (1) | WO1988010300A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6225458B1 (en) | 1978-12-18 | 2001-05-01 | Institut Pasteur | Process for the production of DNA comprising the genome of the hepatitis B virus and vector including it |
| EP0300213A1 (de) * | 1987-06-22 | 1989-01-25 | Hexal-Pharma Gentechnik GmbH & Co. KG | Virale, immunogen wirksame Peptidpartikel von Hepatitis A |
| ZA915593B (en) * | 1990-07-24 | 1993-03-31 | Novagene Inc | Herpesvirus-based viral vector which expresses a foot and mounth disease virus epitope on the surface of virus-infected cells and on the surface of virus particles,and vaccine against foot and mounth disease containing the same |
| EP0491077A1 (de) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten |
| ES2129461T3 (es) * | 1991-11-16 | 1999-06-16 | Smithkline Beecham Biolog | Proteina hibrida entre cs de plasmodium y hbsag. |
| CN1065142C (zh) * | 1992-01-14 | 2001-05-02 | 麦迪瓦赫丁公司 | 组合物用作慢性病毒性肝脏疾病治疗剂的应用 |
| US6169171B1 (en) | 1992-02-27 | 2001-01-02 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBSAG |
| US5928902A (en) * | 1992-02-27 | 1999-07-27 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBsAg |
| WO1994024291A2 (en) * | 1993-04-15 | 1994-10-27 | Washington University | Compositions of antigen containing recombinant salmonella, their use in anti-malarial vaccines and method for their preparation |
| US5733781A (en) * | 1994-07-19 | 1998-03-31 | Gen-Probe Incorporated | Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus |
| AU3222795A (en) * | 1994-08-09 | 1996-03-07 | Ciba-Geigy Ag | Antitumor antisense oligonucleotides |
| GB9720033D0 (en) * | 1997-09-19 | 1997-11-19 | Medeva Plc | Hepatitis B virus polypeptides |
| US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| EP1141313A2 (de) | 1998-12-31 | 2001-10-10 | Chiron Corporation | Verbesserte exprimierung von hiv polypeptiden und herstellung von virusähnliche partikeln |
| WO2000039304A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| ATE384795T1 (de) | 1998-12-31 | 2008-02-15 | Novartis Vaccines & Diagnostic | Modifizierte hiv env polypeptide |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| EP1427806A4 (de) | 2001-08-31 | 2006-04-26 | Chiron Corp | Antigene hiv-typ-b-polypeptide codierende polynukleotide, polypeptide und verwendungen davon |
| KR100465643B1 (ko) * | 2001-09-28 | 2005-01-13 | (주) 에이프로젠 | 비형 간염 바이러스 프리에쓰1 항원 유래의 에피토프 태그및 이에 대한 항체를 이용한 폴리펩티드의 검출 및 정제방법 |
| JP4347694B2 (ja) * | 2001-10-16 | 2009-10-21 | レイベン バイオテクノロジーズ,インコーポレイティド | 癌関連抗原cd46に結合する抗体およびその使用方法 |
| AU2003236728A1 (en) * | 2002-06-10 | 2003-12-22 | Algonomics N.V. | Method for predicting the binding affinity of mhc/peptide complexes |
| AU2003295474B2 (en) * | 2002-11-13 | 2009-07-30 | Macrogenics West, Inc. | Antigen PIPA and antibodies that bind thereto |
| WO2004058807A2 (en) * | 2002-12-24 | 2004-07-15 | Algonomics N.V. | Mhc class i restricted t-cell stimulating peptides from hepatitis b virus |
| AU2004246905B2 (en) * | 2003-06-18 | 2010-01-21 | Biolab Ltd. | Sphingoid polyalkylamine conjugates for vaccination |
| US7906122B2 (en) * | 2003-06-18 | 2011-03-15 | Yissum Research Development Company Of The Hebrew University Of Jersusalem | Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination |
| WO2005018431A2 (en) * | 2003-08-19 | 2005-03-03 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating neurological conditions |
| WO2006085141A2 (en) * | 2004-08-13 | 2006-08-17 | Migenix Inc. | Compositions and methods for treating or preventing hepadnaviridae infection |
| EP2185195A2 (de) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen-plattform |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| WO2014193122A1 (ko) * | 2013-05-31 | 2014-12-04 | (주)셀트리온 | B형 간염 바이러스를 중화시킬 수 있는 결합 분자 |
| US9714284B2 (en) | 2013-07-16 | 2017-07-25 | National Health Research Institutes | Antibodies and method for determining deletions in HBV pre-S2 region |
| WO2016093823A1 (en) * | 2014-12-10 | 2016-06-16 | National Health Research Institutes | Antibodies and method for determining deletions in hbv pre-s2 region |
| AU2020342385A1 (en) | 2019-08-29 | 2022-03-31 | Triad National Security, Llc | Hepatitis B virus vaccines |
| CA3149557A1 (en) | 2019-09-30 | 2021-04-08 | Scott J. Balsitis | Hbv vaccines and methods treating hbv |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US34705A (en) * | 1862-03-18 | Improvement in tompions for fire-arms | ||
| US3636191A (en) * | 1969-10-08 | 1972-01-18 | Cancer Res Inst | Vaccine against viral hepatitis and process |
| FR2480779B2 (fr) * | 1979-08-30 | 1986-07-18 | Anvar | Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur |
| EP0182442B2 (de) * | 1978-12-22 | 1996-04-03 | Biogen, Inc. | Rekombinante DNS-Moleküle und Verfahren zur Herstellung derselben |
| BR7908410A (pt) * | 1978-12-22 | 1980-09-09 | Biogen Nv | Meio para deteccao de anticorpos de vhb no soro do sangue,e processo para deteccao da presenca da infeccao por virus da hepatite b em seres humanos |
| US4935235A (en) * | 1979-05-24 | 1990-06-19 | The Regents Of The University Of California | Non-passageable viruses |
| US5196194A (en) * | 1979-05-24 | 1993-03-23 | The Regents Of The University Of California | Vaccines containing Hepatitis B S-protein |
| IE52036B1 (en) * | 1979-05-24 | 1987-05-27 | Univ California | Non-passageable viruses |
| USRE34705E (en) | 1979-08-30 | 1994-08-23 | Institut Pasteur | Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby |
| US4415491A (en) * | 1980-01-14 | 1983-11-15 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| DE3176404D1 (en) * | 1980-04-22 | 1987-10-08 | Pasteur Institut | Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine |
| FI83662C (fi) * | 1980-07-17 | 1991-08-12 | Scripps Clinic Res | Diagnostik antikropp och foerfarande foer dess framstaellning. |
| GR76274B (de) * | 1981-08-04 | 1984-08-04 | Univ California | |
| AU8746582A (en) * | 1981-09-02 | 1983-03-10 | Biogen N.V. | Hepatitis b virus e type antigen |
| WO1983001783A1 (en) * | 1981-11-23 | 1983-05-26 | University Patents Inc | Control of dna sequence transcription |
| US4741901A (en) * | 1981-12-03 | 1988-05-03 | Genentech, Inc. | Preparation of polypeptides in vertebrate cell culture |
| JPS58194897A (ja) * | 1982-05-07 | 1983-11-12 | Takeda Chem Ind Ltd | 新規dna,その製造方法およびそれで形質転換させた宿主 |
| JPS5936698A (ja) * | 1982-08-20 | 1984-02-28 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞 |
| US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US5198348A (en) * | 1982-08-30 | 1993-03-30 | Amgen Inc. | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| JPS5974985A (ja) * | 1982-10-19 | 1984-04-27 | Takeda Chem Ind Ltd | 新規dna |
| JPS5980615A (ja) * | 1982-10-29 | 1984-05-10 | Takeda Chem Ind Ltd | Dnaおよびその用途 |
| WO1984002534A1 (en) * | 1982-12-23 | 1984-07-05 | Us Commerce | Human growth hormone produced by recombinant dna in mouse cells |
| CA1341116C (en) * | 1983-02-22 | 2000-10-17 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein |
| US4696898A (en) * | 1984-01-16 | 1987-09-29 | Integrated Genetics, Inc. | Vector encoding hepatitis B surface antigen |
| FR2559159B1 (fr) * | 1984-02-02 | 1986-09-12 | Inst Nat Sante Rech Med | Vecteurs viraux de clonage et d'expression d'une proteine dans une cellule eucaryote, comportant au moins une partie du genome d'un retro-virus; cellules eucaryotes transfectees; procede utilisant de telles cellules et proteines obtenues |
| FR2560890B1 (fr) * | 1984-03-07 | 1987-10-16 | Grp Genie Genetique | Composition utile pour la fabrication de vaccins contenant des particules portant l'antigene de surface du virus de l'hepatite b et le recepteur de l'albumine serique humaine polymerisee, cellules animales capables de produire de telles particules et procede pour leur obtention |
| US5324513A (en) * | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
| US5204096A (en) * | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| US4861588A (en) * | 1985-02-05 | 1989-08-29 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US5158769A (en) * | 1984-03-07 | 1992-10-27 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US4777240A (en) * | 1984-03-08 | 1988-10-11 | Scripps Clinic And Research Foundation | SV40 expression vector containing HBxAg as an expression marker |
| US4942125A (en) * | 1984-09-07 | 1990-07-17 | Scripps Clinic And Research Foundation | SV40 expression vector containing HBxAg as an expression marker |
| AU579148B2 (en) * | 1984-03-09 | 1988-11-17 | Scripps Clinic And Research Foundation | Synthetic hepatitis b virus vaccine including both t cell and b cell determinants |
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-
1988
- 1988-06-22 EP EP88109957A patent/EP0300213A1/de not_active Withdrawn
- 1988-06-22 AT AT88109946T patent/ATE207535T1/de active
- 1988-06-22 IL IL86833A patent/IL86833A0/xx unknown
- 1988-06-22 ES ES88109946T patent/ES2167304T3/es not_active Expired - Lifetime
- 1988-06-22 WO PCT/EP1988/000550 patent/WO1988010300A1/en not_active Ceased
- 1988-06-22 IL IL8683288A patent/IL86832A/en not_active IP Right Cessation
- 1988-06-22 CA CA000570100A patent/CA1341074C/en not_active Expired - Fee Related
- 1988-06-22 JP JP63505846A patent/JP2758184B2/ja not_active Expired - Fee Related
- 1988-06-22 KR KR1019890700311A patent/KR890701742A/ko not_active Withdrawn
- 1988-06-22 EP EP88109945A patent/EP0299242A3/de not_active Withdrawn
- 1988-06-22 DE DE3856496T patent/DE3856496T2/de not_active Expired - Lifetime
- 1988-06-22 DE DE2002199017 patent/DE10299017I2/de active Active
- 1988-06-22 JP JP63505505A patent/JPH02501186A/ja active Pending
-
1994
- 1994-06-10 US US08/258,549 patent/US6022543A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/480,757 patent/US6589530B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/488,210 patent/US6110706A/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,173 patent/US6072049A/en not_active Expired - Lifetime
- 1995-06-07 US US08/488,207 patent/US6100065A/en not_active Expired - Lifetime
- 1995-06-07 US US08/484,408 patent/US6117653A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0299242A2 (de) | 1989-01-18 |
| US6022543A (en) | 2000-02-08 |
| US6110706A (en) | 2000-08-29 |
| EP0300213A1 (de) | 1989-01-25 |
| US6589530B1 (en) | 2003-07-08 |
| ATE207535T1 (de) | 2001-11-15 |
| US6117653A (en) | 2000-09-12 |
| EP0299242A3 (de) | 1989-01-25 |
| JPH02501186A (ja) | 1990-04-26 |
| JPH02501187A (ja) | 1990-04-26 |
| DE3856496T2 (de) | 2002-06-27 |
| IL86832A (en) | 2002-09-12 |
| IL86832A0 (en) | 1988-11-30 |
| US6072049A (en) | 2000-06-06 |
| DE10299017I1 (de) | 2002-08-29 |
| JP2758184B2 (ja) | 1998-05-28 |
| IL86833A0 (en) | 1988-11-30 |
| KR890701742A (ko) | 1989-12-21 |
| WO1988010300A1 (en) | 1988-12-29 |
| ES2167304T3 (es) | 2002-05-16 |
| CA1341074C (en) | 2000-08-08 |
| HK1002900A1 (en) | 1998-09-25 |
| US6100065A (en) | 2000-08-08 |
| DE3856496D1 (de) | 2001-11-29 |
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