DE10258992A1 - Pad for dematological and cosmetic use - Google Patents

Abstract

Pad for dermatological and cosmetic use, containing a polymer-based carrier material, in particular alginic acid-based, which has a sponge-like and / or sponge-like structure and preferably at least one active ingredient contained in ginseng and / or at least one further active ingredient-containing formulation and, if appropriate, skin care products and / or contains cosmetics.

Description

Object of the present invention is a requirement for the dermatological and cosmetic use, which in particular suitable for use as a face mask.

From the DE 299 15 656 . DE 101 64 680 and DE 201 198 43 sponge-like materials based on collagen are known. The materials described are said to produce a satiety effect due to their volume in the stomach. However, only oral administration and use are described.

Because of the ever increasing health awareness is a further improvement of carriers or conditions for the dermatological Use necessary.

Object of the present invention is a new skin-friendly Provide a condition that is inexpensive to manufacture Environmental awareness of users is accommodating and not toxic Contains substances.

This object is achieved by a Edition for dermatological use containing a polymer-based carrier material, dissolved in particular alginic acid base. The support material serves to build up the edition. According to the invention, however, this can be further Contain substances.

Under dermatological use is understood to mean any skin contact of the carrier material which is made to effect an effect. Such effects can e.g. B. cosmetic care or therapeutic treatment by delivery of an active ingredient (e.g. through its penetration into / through the Skin).

Indispensable property of the carrier material according to the invention Is that it is is skin-friendly. It also has to be producible so that there is as little contamination as possible contains which "bleed out" during use and then disadvantageous Effects such as B. cause skin irritation.

Different synthetic, semi-synthetic or natural Polymers in the edition according to the invention be included.

Suitable synthetic polymers are z. B. polyurethanes, polyacrylates, polymethacrylic acid esters or homo- and copolymers of vinyl acetate.

In an embodiment of the present invention can organic polymers are used. Organic polymers can be of their origin or synthesis, of course, semi-synthetic or be synthetic. Examples of suitable polymers are polyurethanes, Polyacrylates, poly (meth) acrylic acid esters, Homo- and copolymers of vinyl acetate, polyvinyl acetate, polyacrylic acid, polyethylene glycol, Polyvinyl pyrolidone, cellulose, ether, diethyl cellulose or cellulose ester, such as cellulose diacetate, cellulose triacetate, cellulose acetate propionate and cellulose acetate, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, or sodium carboxymethyl cellulose (preferably such compounds with higher Viscosity); butyrate, lower substituted hydroxypropyl cellulose, carboxymethyl cellulose (with 2- or 3-valent cations), sodium starch glycolate, glycosaminoglycans such as chondroitin sulfate or hyaluronic acid, collagen, albumin, keratins, Conchagene, Fibroin, Elastine, Chitin.

Furthermore, hydrocolloids, in particular Based on polysaccharides.

The use of is also conceivable anionic polymers. Which includes preferably polysaccharides, especially those containing polyuronic acid Polysaccharides. Alginic acids, their derivatives and salts are particularly preferred (Alginates). However, all other uronic acid-containing compounds can also be used according to the invention come. Preferred according to the invention is also the use of cellulose or cellulose derivatives. Conceivable is the use of synthetic or semi-synthetic cellulose derivatives, such as B. carboxymethyl cellulose or polyacrylates.

Cellulose means water-insoluble polysaccharides with a gross composition (C ₆ H ₁₀ O ₅ ) _n . More specifically, it is an isotactic (-1,4-polyacetal of cellobiose (4-O - (- D-glucopyranosyl-D-glucose).

As cellulose derivatives are generally by polymer-analogous reactions defined chemically modified celluloses. They include both products where only, e.g. B. about Esterification and / or etherification reactions, hydroxy hydrogen atoms the anhydroglucose units of cellulose by organic or inorganic groups are substituted, as well as those under formal Exchange of hydroxyl groups of natural polymers for functional ones Groups that don't have an oxygen atom are bound (e.g. deoxycelluloses) or via intramolecular Elimination of water (anhydrocelluloses, celluloses) or oxidation reactions (Aldehyde, keto and carboxy celluloses) are formed. Even products, those cleaving the C2, C3-carbon bond of the anhydroglucose units accrued (dialdehyde and dicarboxy celluloses), in which the for the Cellulose characteristic monomer unit is no longer in tact, are counted among the cellulose derivatives. Are cellulose derivatives also about other reactions accessible, z. B. about Crosslinking or graft copolymerization reactions.

According to the invention, cellulose or cellulose derivatives can can be used in a mixture with pectins. Mixtures are also containing alginic acid or their derivatives are conceivable.

The carrier material based on alginic acid is particularly gentle on the skin and, as a natural material, it meets ecological requirements. It is also easy to work with and free of skin-irritating substances.

Alginic acid is a linear polyuronic acid varying proportions of D-mannuronic acid and L-guluronic acid through β-glycosidic Bonds linked together are, wherein the carboxyl groups are not esterified. One molecule of alginic acid can from around 150-1050 Uronic units with the average molecular weight in a range of 30-200 kDa can vary.

The polysaccharide is alginic acid a component of the cell walls of brown algae. The proportion of alginic acid in the dry mass of Algae can make up to 40% of this. The alginic acid is obtained by alkaline extraction using methods known per se according to the prior art of the technique. The resulting powdered alginic acid is thus purely vegetable and has a high biocompatibility. she can form 300 times the amount with formation of highly viscous solutions absorb their own weight in water. In the presence of multivalent Cations form alginic acid so-called gels. The formation of alginate gels in the presence of divalent Cations such as calcium or barium are described in Shapiro I., et al. (Biomaterials, 1997, 18: 583-90) described. The latter is due to its toxicity for use not suitable in biomedicine. In addition to calcium chloride supplies calcium gluconate also suitable divalent cations. Generally are all physiologically harmless poly cations, especially divalent ones Cations can be used.

With regard to the low esterification Polymers can also use low-esterified pectins according to the invention. pectins consist of chains of α-1,4-glycosidic connected galacturonic acid units, their acid groups to 20–80% are esterified with methanol. One differentiates between highly esterified (> 50%) and low esterification (<50%) pectins. The molar mass varies between 10-500 kDa. The extraction of Pectins are obtained by acid extraction using methods known per se according to the status the technology from the inner parts of citrus fruit peel, leftovers or beet pulp. The resulting pectins (apple pectin, citrus pectin) are therefore purely vegetable and have high biocompatibility on. You can Form gels while absorbing water.

Here too is the use of pectin gels in the presence of divalent cations, such as calcium or barium. The latter is also here due to its toxicity for use in biomedicine however not suitable. In addition to calcium chloride, calcium gluconate also provides suitable divalent cations. The use of magnesium salts or is also conceivable a mixture of different physiologically harmless divalent Cations.

Inorganic substances such as MgCl ₂ , CaSO ₄ , Na ₂ CO ₃ , CaCO ₃ , polysilicic acids and clay minerals (such as montmorillonites, zeolites, silicas) or organic substances such as mono- and / or disaccharides (mannose, glucose, sucrose, sorbitol) can be used as further compounds ), Lactose, tartaric acid or urea can be used.

Finally, as natural polymers are still Guar, locust bean gum, konjac flour, starch, pectin, soy protein, e.g. Whole soy flour, milk protein, To name lupine protein.

According to the invention, they can also be considered anionic mucilages, e.g. B. xanthan, tragacanth and insoluble polysaccharides, e.g. B. chitin, e.g. Chitin derivatives.

The use of sponge-like is particularly favorable and / or sponge-shaped Alginate-based materials.

Among such sponge-like and / or sponge-like materials are fixed according to the invention or semi-rigid elastic foams understand that from gas-filled for example polyhedral Cells consist of highly viscous and / or solid cell webs are limited.

In addition to the alginates both natural occurring sponges, semi-synthetic or synthetic sponge-like structures can be used from the abovementioned polymers. Examples of synthetic sponge-like materials are polyurethanes, polyacrylates, poly (meth) acrylic acid derivatives, Homo and copolymers of vinyl acetate. To the natural and semi-synthetic polymers include. a. Cellulose, cellulose ether or cellulose esters such as cellulose acetate and cellulose acetate phthalate. examples for natural Polymers are polysaccharides such as tragacanth, xanthan gum and guar gum and their salts and derivatives. The use of chitin and chitin derivatives is possible. In addition, substances with a fiber structure such as scleroproteins are preferred z. B. collagen, keratin, conchagens, fibroin, elastin and chitin used. About that polysaccharides which are crosslinked in a stable manner are also an object of the present invention.

The sponge-like or -shaped structures are produced using methods known per se according to the prior art. Reference is made here to WO98 / EP96 / 03950, which is also the subject of the present invention. Depending on the starting material used, a foam can be obtained in the simplest case by blowing in, by beating, shaking, spraying or stirring in the gas atmosphere in question. In the case of the polymers, the foam structure arises due to chemical reactions. So z. B. foamed by adding blowing agents that decompose at a certain temperature during processing with gas formation, or by adding liquid solvents during the polymerization. Foaming takes place either when leaving the extrusion die, ie in the on after extrusion or injection molding or in open molds. Hardening takes place under the conditions which are characteristic of the respective chemical compound of the carrier material.

The materials can also be dried porous Consist of gel or foam. Anionic materials are preferred Polymers of alginic acid and their salts (alginates) are used. These materials can then as part of the preparation or treatment z. B. by exposure to water swell.

Other anionic polymers, their Can be used in combination with alginic acid are polysaccharides and containing polyuronic acid Polysaccharides. But also low ester pectins, xanthan, tragacanth, Chondroitin sulfate and all other uronic acid-containing compounds can be used according to the invention come. The use of synthetic or semi-synthetic is also conceivable Cellulose derivatives, such as. B. carboxymethyl cellulose or polyacrylates.

Dried are advantageous according to the invention Gels or foams containing mixtures of anionic polymers of the salts of alginic acid. Furthermore, the previously mentioned anionic polysaccharides, particularly preferably mixtures containing polyuronic acid and low-esterified polysaccharides and especially mixtures containing salts of pectins. Even low esterification Pectins, xanthan, tragacanth, chondroitin sulfate and all others containing uronic Connections can according to the invention come.

The pectins are purely vegetable and are highly biocompatible. You can take water Form gels. Here too, the use of pectin gels is present divalent cations known as calcium or barium. The latter is here too due to its toxicity for use in biomedicine however not suitable. In addition to calcium chloride, calcium gluconate also provides suitable divalent cations. The use of is also conceivable Magnesium salts or a mixture of different physiological harmless divalent cations.

According to the invention, the edition can at least contain an active ingredient contained in ginseng.

Active ingredient in the sense of the invention are all substances with a pharmaceutical or biological effect to understand.

Ginseng is a perennial, anemone-like Araliacee (Panax ginseng CA Mayer), which grows wild in the mountain forests of East Asia and is also cultivated, the root of which contains steroid derivatives. The ingredients isolated so far include sitosterol and more than 10 triterpene glycosides ginsenosides. The ginsenoids are a group of glycosides of tetracyclic triterpenes (sapogenins) from the ginseng root (Panax ginseng): 24-Dammaren-3,12,20-triol, the (3a, 12b, 20S) form is called Betulafolienttriol and the diastereomeric (3b, 12b, 20S) -form protopanaxadiol. Protopanaxatriol has an additional 6a-hydroxy group. The sugar components in these glycosides are D-glucopyranose, L-arabinopyranose, L-arabinofuranose, D-xylofuranose and D-xylopyranose as well as L-rhamnopyranose. The ginsenosides are said to have anti-ischemic, immunostimulating, antithrombotic (PAF-antagonist.), Hypoglycemic and cholesterol-lowering properties. According to new studies, the ginseng extract generally stimulates protein and nucleic acid metabolism. Furthermore, one found, among other things, an essential oil responsible for the ginseng smell, in which a number of sesquiterpenes were characterized. Ginseng is mainly used as Roborans and Geriatricum (Source: Römpp Lexikon Chemie - CD Version 2.0, Stuttgart / New York: Georg Thieme Verlag 1999 ).

In short, ginseng is well known for its health-promoting Use as a universal agent. Ginseng acts as a stimulant and stimulating cardiovascular agent, as an antidepressant and as Nervennahrung. In addition, ginseng has a strong immunostimulatory Effect, promotes the build-up of body protein, improved the ability to remember and concentrate just like the mental and physical Resilience. Besides practicing Ginseng has a positive impact on adult diabetes, stimulates the Metabolism, regulates blood fat levels and lowers blood pressure.

Ginseng increases the adaptability and tolerance of the body to stress and protects against the negative effects of permanent stress. In addition, ginseng increases physical performance and generally promotes the building processes and provides the body with more energy; one speaks of an anabolic effect. Ginseng also increases concentration and alertness, improves thinking and memory and works against fatigue and exhaustion. Furthermore, ginseng has a stimulating or calming effect on the central nervous system, as required. Ginseng is able to lower an elevated blood sugar level and to raise an excessively low blood sugar level. Ginseng is also known to stimulate the immune system through several mechanisms. Ginseng is also able to activate important enzymes in cell metabolism and the liver. This leads to an increased synthesis of DNA, RNA and important proteins. In particular, the amount of reduced glutathione is increased, which plays an important role in cell metabolism, especially in the liver. In addition, the active ingredients contained in ginseng have an antioxidative effect, ie they especially prevent free radicals, which otherwise damage cells. Ginseng is used to support the therapy of cardiovascular diseases in which it has blood liquefies, controls blood pressure, lowers cholesterol, lowers the heart's oxygen needs and strengthens the heart muscle. Ginseng is also able to influence the blood count through the active ingredients it contains, in particular the excitation of the bone marrow cells for division and blood formation is known. Ginseng is also known to improve respiratory functions and reduce inflammation through its use. In addition, ginseng is said to have a sexual stimulating effect.

In particular, the influence of im Active ingredients contained in ginseng on the immune system has been studied. It has been demonstrated that taking a standardized Ginseng extract increases the immune response to a flu shot that acidic polysaccharides of the root the production of interleukin 8 promote, the ginseng polysaccharides induce the production of interferon, phagocytosis of the reticuloendothelial system, production of antibody and promote an increase in the continent in the blood, as well as the cellular immune response (Scaglione et al, Drugs Expl. Clin. Res. 23 82), 1996: 65-72; Sonoda et al, Immunopharmacology 1998; Smolina et al, Antibiotic Khimioter 1998; Chang-Xiao et al, Ethnopharmacology 1992; Jie et al, Argenst Actions 15 (3-4), 1984: 386-91; Kim et al, Immunopharmacology and Immunotoxicology 12 (2), 1990: 257-76).

By combining the at least an active ingredient contained in ginseng and the material based on alginic acid in addition to the biologically advantageous material also improves well-being as well as weight loss positive affected.

As active ingredients contained in ginseng all come according to the invention Substances contained in ginseng are considered. In particular fall under it the above steroid derivatives, sitosterol, ginsenoids and essential oils. As well belong plus active ingredients contained in ginseng that have not yet been isolated and / or have been characterized. These active ingredients can be made from the ginseng itself or be produced artificially. The invention also includes the use of liquid, pasty, solid, granular and powdery Preparations, extracts and partial extracts, solutions and melts of ginseng, synthetically produced ingredients of ginseng and / or their Mixtures. Natural ginseng is preferably used. It particularly preferably comes from Asia, in particular Korea, because the ginseng from there is considered the most effective.

According to the invention, the edition can be a (further) Contain formulation containing active ingredient. This can be done alone or additionally to the active ingredient contained in ginseng. Hereinafter are examples of active ingredient according to the invention Reproduced formulations from different therapeutic classes, but not limiting for are the present invention.

Examples of analgesics (opioids) are: Alfentanil, buprenorphine, cetobemidone, dextromoramide, dextropropoxyphene, Fentanyl, flupirtine, hydromorphone, levomethadone, levorphanol, meptazinol, morphine, Nalbuphin, oxycodone, pentazocin, pethidine, piritramide, tilidine, Tramadol.

Examples of analgesics (non-opioids) are: acetylsalicylic acid, Benzyl almondate, bucetin, ethenzamide, ketorolac, metamizole, morazone, Paracetamol, phenacetin, phenazone, propyphenazone, salicylamide.

Examples of antiallergics / antihistamines are: Anatazoline, astemizole, azelastine, bamipine, brompheniramine, buclizine, Carbinoxamine, cetririzine, chlorphenamine, clemastine, cyslizine, cyproheptadine, dimenhydramine, Doxylamine, fexofenadine, ketotifen, loratadine, mepyramine, mizolastine, Nedrocromil, oxatomide, oxomemazine, pheniramine, phenyltoloxamine, spaglumic acid, terfenadine, Triprolidine.

Examples of antibiotics / chemotherapy drugs are: Amikacin, Gentamicin, Kanamycin, Paromomycin, Sisomicin, Streptomycin Tobramycin, chloroquine, halofantrine, hydroxychloroquine, mefloquine, Proguanil, ethambutol, isoniazid, rifabutin, rifampicin, cefacetril, Cefaclor, cefadroxil, cefalexin, cefalotin, cefamandol, cefazolin, Cefixime, cefmenoxime, cefoperazone, cefotaxime, cefotetan, cefotiam, Cefoxitin, cefpodoxime (proxetil), cefradin, cefsulodine, ceftazidime, Ceftizoxime, ceftriaxone, cefuroxime (axetil), latamoxef, cinoxacin, Ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pipemidic, Rosoxacin, clarithromycin, erythromycin, roxithromycin, amoxicillin, Ampicillin, apalcillin, azidocillin, azlocillin, bacampicillin, Benzylpenicillin, carbenicillin, carindacillin, dicloxacillin, flucloxacillin, Mezlocillin, oxacillin, phenoxymethypenicillin, piperacillin, pivampicillin, Propicillin, ticarcillin, colistin, teicoplanin, vancomycin, co-trimoxazole, Sulfametoxydiazine, doxycycline, oxytetracycline, tetracycline, atovaquone, chloramphenicol, Fosfomycin, imipenem, metronidalzol, nitrofurantoin, pentamidine, Taurolidine, trimethoprim.

Examples of antifungals are: amorolfine, amphotericin B, bifonazole, chlormidazole, ciclopiroxolamine, clotrimazole, croconazole, Econazole, fenticonalzol, fluconazole, griseofulvin, isoconazole, itraconazole, Ketoconazole, miconazole, naftifine, naystatine, omoconazole, oxiconazole, Terbinafine, terconazole, tioconazole, tolnaftate.

Examples of anti-rheumatic drugs are: acemetacin, azapropazon, benorilat, bumadizon, carprofen, choline salicylate, diclofenac, diflunisal, etofenamate, felbinac, fenbufen, fenoprofen, flufenamic acid, flurbiprofen, ibuprofen, indomofamobamone, moxinoxamonamone, melonacidamonamone, melonacidamonamone, melonacidamonamone, melonacidamonamone, melonacidamone, , Naproxen, Nifenazon, Nifluminsäure, Oxyphenbutazon, Phenylbutazon, Piroxicam, Pirprofen, Proglumetacin, Pyrazinobutazon, Salsalat, Sulindac, Suxibuzon, Tenoxicam, Tiapro fensic acid, tolmetin, auranofin, aurothioglucose, aurothiomalate, aurothioplypeptide, chloroquine, hydroxychloroquine, penicillamine, ademetionin, benzydamine, bufexamac, famprofazone, glucosamine, oxaceprol.

Examples of blood circulation promoters Medium / nootropics are: Buflomedil, Buphenin, Dextran 40, Dihydroergotoxin, Iloprost, meclofenoxate, nicergoline, nicotinic acid, pentifylline, piracetam, Piribedil, pyritinol, tolazoline, Viquidil.

Examples of glucocorticoids are: betamethasone, Budesonide, cloprednol, cortisone, dexamethasone, flunisolide, fluticasone, Hydrocortisone, methylprednisolone, paramethasone, prednisolone, prednisone, prednylidene, Triamcinolone.

Examples of local anesthetics are: articaine, benzocaine, Bupivacaine, butanilicain, chloroethane, cinchocaine, cocaine, etidocaine, Fomocaine, Lidocaine, Mepivacaine, Myrtecain, Oxetacaine, Oxybuprocain, Polidocanol, Prilocaine, Procaine, Proxymetacaine, Quinisocaine, Tetracaine.

Examples of migraine drugs are: ergotamine, lisuride, Naratriptan, Pizotifen, Sumatriptan, Zolmitriptan.

Examples of muscle relaxants are: Alcuronium, Atracurium, Baclofen, Carisoprodol, Chlormezanon, Clostridiumtoxin botulinum toxin A.

Examples of neuroleptics are: benperidol, chlorpromazine, Droperidol, flyeanzine, haloperidol, melperon, promethazine, zuclopenthixol.

Examples of sedatives / hypnotics are: Amobarbital, chloral hydrate, clomethiazole, glutethimide, hexobarbital, Methaqualon, methyprylon, pentobarbital, scopolamine, secbutabarbital, Secobarbital, vinylbital, zolpidem, zopiclone.

Examples of sex hormones are: chlorotrianisen, Clomiphene, clostebol, cyproterone, drostanolone, epimestrol, estradiol, Estriol, estrone, ethinylestradiol, flutamide, fosfestrol, conjugated Estrogens, medroxyprogesterone, mesterolone, mestranol, metenolone, Methyltestosterone, nandrolone, oxymetholone, polyestradiophosphate, Quinestrol, stanozolol, testosterone.

Examples of antispasmodics are: atropine, Butylscopolamine, flavoxate, glycopyrronium, mebeverin, methylscopolamine, Oxybutynin, Tiropramid, Trospiun.

Examples of transquilizers are: alprazolam, bromazepam, Brotizolam, Buspirone, Camazepam, Chlordiazepoxide, Clobazam, Clonazepam, Clorazepate, clotiazepam, diazepam, flunitrazepam, flurazepam, hydroxyzin, Ketazolam, loprazolam, lorazepam, lormetazepam, medazepam, meprobamate, metaclazepam, Midazolam, Nitrazepam, Oxazepam, Oxazolam, Prazepam, Temazepam, Tetrazepam, triazolam.

Examples of venous agents are: aescin, Calcium dobesilate, coumarin, diosmin, rutoside, troxerutin.

Examples of vitamins are: alfacalcidol, Allithiamine, ascorbic acid, Biotin, calcifediol, calcitriol, colecalciferol, cyanocobalamin, Ergocalciferol, folic acid, Hydroxocobalamin, nicotinamide, pantothenic acid, phytomenadione, pyridoxine, Retinol, riboflavin, thiamine, tocopherol, transcalcifediol.

In particular, antifungals, antiseptics, Antibiotics, sulfonamides, disinfectants, corticoids as well shale oil and. Tar sulfonates, astringents and antihidrotics in the edition be included.

The examples given above Active ingredients are not final enumerated but can other active ingredients may be included in the edition, especially if if the edition z. B. is used in the form of a drug depot patch. Main criterion for the selection of active ingredients is that they penetrate the skin or be re-or absorbed by this.

In addition to the aforementioned active ingredients can also remedies for acne, psoriasis, seborrhea and itching, as well Keratolytics and in a broader sense skin care products and / or cosmetics be included in the edition.

For skin care (skin care products) are numerous common Products can be used. The skin care that follows cleaning has two Main goals: On the one hand, the skin should be uncontrolled when washing deprived ingredients such as horny cells, skin lipids, acid generator and return water in the natural Equilibrium. On the other hand, they should be natural Aging process of the Skin as well as the possible Damage from Weather and environmental influences largely counteract. preparations for skin care and skin protection are in large numbers and in many forms of preparation offered. The most important are skin creams, lotions, oils and gels. The basis of the creams and lotions are emulsions oil in water or water in oil form. The main components of the oil or fat or lipid phase are fatty alcohols, fatty acids, fatty acid esters, Waxes, petroleum jelly, paraffins and other fat and oil components mainly natural Origin. In the aqueous phase are mainly alongside water moisture regulating and moisture preserving substances contain as an essential skin care ingredient, also consistency or viscosity regulating Medium. Other additives such as preservatives, antioxidants, complexing agents, perfume oils, colorants as well as special active ingredients (see above) depending on their solubility and their stability properties one of the two phases mentioned above.

Skin oils are among the oldest skin care products and are still used today. The basis is non-drying vegetable oils, such as almond oil or olive oil with additives of natural vitamin oils such as wheat germ oil or avocado oil, as well as oily plant extracts, e.g. B. St. John's wort, chamomile and the like. The addition of antioxidants against rancidity is essential. Desired fragrance notes are achieved by perfume or essential oils. On The addition of paraffin oil or liquid fatty acid esters serves to optimize the application properties.

Skin gels are semi-solid transparent Products that are stabilized by appropriate yellow formers. A distinction is made between oleogels, hydrogels and oil / water gels. The type selection depends on the desired Application. The oil / water gels contain high levels Emulsifier shares and have certain advantages over emulsions.

The skin treatment and care products also include the means for hair treatment. Because hair care is cleaning from Includes scalp and scalp hair equally the shampoo special skin-care ingredients.

In addition to the pure skin care products can also Cosmetics (cosmetic products, personal care products) be available in the edition. Herewith are such means to beautify the Appearance or the broadcast meant. These include fragrances, for example substances containing pigments, such as blush, powder, lipsticks, Song line, eyebrow pencils, tinting cream, Contour pencils, nail polish or deodorants.

The at least one active ingredient contained in ginseng and / or the further active ingredient and the skin care products and / or Cosmetics can in, on or on the carrier material be applied or applied.

In a variant of the invention, the Active ingredients contained in ginseng and / or the other active ingredients and / or the skin care products and / or cosmetics on the surface or part of the surface of the material are applied. Suitable adhesion promoters can be used for this be used.

Fixed agents come as semi-solid or liquid Substances into consideration. These can be powders, pastes, solutions, Trade melts or foils. In the latter case, for example foil-shaped Adhesion promoter layer have adhesive properties on both sides and in this way the cohesion of the carrier material with the active ingredients and / or the layer containing skin care products and / or cosmetics guarantee.

By loading the carrier material with this connecting layer a connection between the support material and the active ingredients and / or skin care products and / or cosmetics containing layer achieved. The duration of the existing connection depends on it of the "solubility" of the used and substances contained in the connecting layer on the skin under the treatment or application conditions, d. H. of penetration and subsequent Absorption or absorption.

Furthermore, the use of filamentary or tissue-like Material conceivable by which the desired duration of the connection between carrier material and the active ingredients and / or skin care products and / or cosmetics containing layer can be controlled. Accordingly, too an edition containing thread-like and / or as a connecting means gewebeänhliche Fabrics object of the invention.

Compounds preferably come as adhesion promoters considering the natural contain synthetic and semi-synthetic polymers. in principle nonionic and ionic polymers come into consideration. Basically come all hot melt adhesives and contact adhesives known from the prior art in question if they are for Pharmaceuticals (dermatics) are suitable and under conditions of use soluble are. In a special design variant the present invention is the adhesion promoter starch derivatives, Cellulose derivatives, gelatin or polysaccharides, preferably those containing polyuronic acid Polysaccharides, e.g. B. Polyalginates. Hypomellosis, for example, Carmellose, called metholose.

Particularly preferred polyuronic acid-containing Polysaccharides are alginic acids and their salts (alginates). But also low ester pectins, Xanthan, tragacanth, chondroitin sulfate and all other uronic acid-containing Connections can according to the invention come.

The edition according to the invention using the Adhesion promoter described after the preparation or at the application on the skin in carrier material and the active ingredient-containing formulations) and / or skin care products and / or layers containing cosmetics. The active ingredients and / or the skin care products and / or cosmetics may be due to which penetrate into the skin, i.e. because of that be absorbed (or absorbed) by the skin. So it is possible delayed, long-lasting dosing or release of the active ingredients and / or To achieve skin care products and / or cosmetics.

According to the invention, however, it is also possible to use different ones Combine active ingredients, skin care products or cosmetics. So can in addition to the described adhesive that is soluble on the skin, an adhesive agent be used that does not dissolve on the skin under the treatment conditions. On This adhesion promoter is then applied to active ingredients that should remain on the skin to develop their effect there.

The active ingredients contained in ginseng can also be used and / or optionally the active ingredients and / or the skin care products and / or Cosmetics directly on the carrier material be brought up if they are e.g. B. adhesion-promoting substances exhibit or adhesion promoting under pressure at temperatures Develop properties.

Furthermore, it is particularly preferred the active ingredients contained in the ginseng and / or possibly the Active ingredients and / or the skin care products and / or cosmetics in the carrier material z. B. to bring in during its manufacture.

The material can also, according to the invention, for. B. are in the form of powder. According to the invention, this includes both finely divided powders, granules, adsorbates and beadlets.

The production of powdered materials can be done in different ways. For example, for manufacturing one or more swellable carrier materials in a mixer or in a fluidized bed reactor submitted, and then the further components are added. According to the invention can be discontinuous or continuously operating mixers can be used. The carrier material may be presented together with additives. Classic examples are flight share mixers, cone screw mixers or similar Apparatuses. Alternatively, the product is mixed using a Movement of the entire container possible. Examples of this are tumble mixers, drum mixers etc. Another possibility consists in the use of pneumatic mixers.

The dosage or addition of im Active ingredients contained in ginseng or other active ingredients and / or the skin care products and / or cosmetics may be carried out together with Additives, e.g. B. about Devices for dripping or spraying. Examples of this are lances, Shower heads, Single-component or multi-component nozzles, In rare cases rotating drip or atomizing devices. In the simplest case, the addition is also locally concentrated Jet possible. Alternatively, you can use the mixer first the active ingredient contained in the ginseng and / or the further active ingredient and / or the skin care products and / or cosmetics are presented, then the volume-increasing material give up. The addition of the active ingredient contained in ginseng and / or further active ingredient and / or skin care products and / or cosmetics can with overpressure, Normal pressure or under vacuum, counter atmosphere, preferably at normal pressure or negative pressure. To increase the loading of the material and to minimize the influence of oxygen, it can be beneficial the mixer containing the material before adding the ginseng contained active ingredient and / or further active ingredient and / or the Evacuate skin care products and / or cosmetics and if necessary with Cover protective gas. Soaking too of the carrier materials with appropriate solutions or extracts of the active ingredients etc. is conceivable.

According to the invention, powdery, swellable materials can also be produced by the processes of the spray formulation. Here, for example, in an initial step, an aqueous solution of a protective colloid, e.g. B. gelatin and / or gelatin derivatives, and / or gelatin substitutes with the addition of the materials described above and by adding the active ingredients contained in ginseng and / or other active ingredients and / or skin care products and / or cosmetics with stirring, a dispersion is first prepared, wherein the aqueous solution of the colloid represents the homogeneous phase of the dispersion. Apparatuses in which such spray formulations can be produced are, for example, in the EP 0074050 B1 described.

The production of granules can can be achieved in that a mixer the swellable Materials and / or spray dried powders as well as active ingredients and possibly active components and binders and / or Skin care products and / or cosmetics and aggregates granules be generated. Can as a mixer For example, paddle mixers or flight share mixers are used become. The liquid Components can can be added in various ways, e.g. B. dripped or sprayed be so that a pasty, sticky Mass arises. about suitable choice of the speed of the mixing tools and / or high-speed Knife becomes pasty The mass is broken up and compact granules are formed. Very large chunks can go through Mixing tools and knives cut and fine powder on the other be agglomerated.

For example, a solution from Sodium alginate made in water and with the addition of calcium salts thickened. By incorporating air and, if necessary, adding A gel or foam can be obtained from surfactants. By freezing and then Freeze drying turns the alginate gel or foam into a dry gel or dry foam (sponge). The production of pectin-containing Gel or foam is carried out in an analogous manner, as is the production of gels or foaming containing mixtures of anionic polymers.

In addition to the addition of inorganic or organic calcium salts, such as. B. calcium chloride or calcium gluconate, it is also conceivable to use magnesium salts and mixtures of different ones physiologically harmless divalent cations.

According to the invention, the addition of salts can also physiologically safe trivalent cations, e.g. B. of soluble Aluminum salts are made. Here, the production of the materials according to the invention by adding soluble aluminum salts to a watery solution of anionic polymers, preferably alginates and / or pectins, according to a manufacturing process of the type described above. Particularly suitable soluble Aluminum salts are aluminum chloride or aluminum sulfate. The soluble Aluminum salts can used alone or in combination.

According to the invention, in addition to the soluble aluminum salts, which in turn can be used alone or in combination also salts of divalent cations, such as. As calcium or magnesium salts or a combination thereof, can be used in the production of the carrier materials according to the invention.

The shape of the carrier materials according to the invention or edition itself can by pressing the pasty, sticky phases during the Granulation process through the die of an extruder.

Furthermore, the edition according to the invention can for example in the form of a plaster, a compress, a wrap, a pack or edition, in particular in the form of a face mask.

In addition, the edition or the carrier material according to the invention have a coating as the outer layer, which acts as a protective layer and protects the agent and only when preparing or using, for example under the influence of water.

The material according to the invention and the materials used active substances contained in ginseng and possibly further active substances and / or the skin care products and / or cosmetics can contain further auxiliaries.

Examples include the following To understand substances, which, however, are not limiting for the present Invention are: Water-insoluble auxiliaries or mixtures thereof, such as lipids, etc. a. Fatty alcohols, e.g. B. cetyl alcohol, Stearyl alcohol and cetostearyl alcohol; Glycerides, e.g. B. Glycerol monostearate or mixtures of mono-, di- and triglycerides of vegetable oils; hydrogenated oils, such as hydrogenated castor oil or hydrogenated cottonseed oil; Waxes, e.g. B. beeswax or carnauba wax; solid hydrocarbons, z. B. paraffin or earth wax; Fatty acids, e.g. B. stearic acid; certain Cellulose derivatives, e.g. B. ethyl cellulose or acetyl cellulose; polymers or copolymers, such as polyalkylenes, e.g. B. polyethylene, polyvinyl compounds, z. B. polyvinyl chloride or polyvinyl acetate, and vinyl chloride-vinyl acetate copolymers and copolymers with crotonic acid, or Polymers and copolymers of acrylates and methacrylates, e.g. B. copolymers of acrylic acid ester and methyl methacrylate, be used.

Except for the additives mentioned can they Edition or support materials according to the present Invention in addition Filling, explosive, Binders, lubricants and carriers contain that have no decisive influence on the drug delivery. Examples include a. Betonff (aluminum oxide-silicon oxide hydrate), silica, Cellulose (usually microcrystalline cellulose) or cellulose derivatives, e.g. B. methyl cellulose, Sodium carboxymethyl cellulose, sugars such as lactose, starches, e.g. B. corn starch or derivatives thereof, e.g. B. sodium carboxymethyl starch, starch starch, Phosphoric acid salts, e.g. B. di- or tricalcium phosphate, gelatin, stearic acid or suitable salts thereof, e.g. B. magnesium stearate or calcium stearate, Talc, colloidal silicon oxide and similar auxiliaries.

The active substances mentioned and / or Skin care products and / or cosmetics can be in the form of the invention a powder, a paste, a film, as a solution, as a melt and are preferably introduced into the carrier material.

Under certain circumstances, depending on the type of construction the edition, d. H. Mode of application, application or application of the active ingredients, additionally a sustained release drug can be achieved like this z. B. is the case with depot patches.

As already explained above, to ensure that the on or in the carrier material applied or incorporated active ingredients contained in ginseng and / or if necessary, the active ingredients and / or the skin care products and / or cosmetics on the skin of the carrier material solve or are released and if necessary get into the skin.

There may also be additional layers be also active ingredients and / or skin care products and / or Cosmetics included. In this way, a combination of active ingredients and / or skin care products and / or cosmetics are achieved which under the conditions of use (heat, moisture, etc.) and after solve (or are released) and their effect directly on the skin if necessary to unfold. Depending on the type of active ingredient, it is also possible that some of it on the skin remains and on the other hand penetrates the skin or from it is recorded. If additional material is applied to the carrier material Any other treatments can be carried out. Under otherwise, a sustained release release can also have a depot effect or delayed Release of the different active ingredients, skin care products, etc. be achieved.

Multilayer active ingredient structures are also conceivable, where the adhesion promoter is partly on the skin solve and partially not solve.

In this way, any Produce drug combinations that, for. T. on the skin and z. T. in the body take effect.

The pad can be used as a plaster, compress, wrap, Pack, edition, especially as a face mask.

The present invention is accomplished by the examples below explains but not limiting for are the present invention. Show it:

1 a face mask designed according to the invention and

2 a dressing according to the invention designed as a wound dressing.

1 shows a designated as a face mask, according to the invention, designated 10 as a whole moderate support made of a carrier material based on polymer, especially alginate. The actual mask 1 has an essentially triangular shape with rounded corners, which tapers down towards the chin of an imaginary person wearing the mask. It consists of a sponge-like polymer-based material with a material thickness of 0.5 mm to 5 mm. The material can additionally contain the above-mentioned active ingredients and / or cosmetics etc.

The mask has matings for the eyes 2 and a pair for the nose 3 on. These are arranged and have such a dimension that they can be worn by the average user, ie the openings at the corresponding points coincide with the eyes or nose of the wearer. Furthermore, the mask can have pores 4 have, which can be arranged distributed uniformly or locally grouped over the mask. They serve z. B. ventilation of the skin under the mask. The nostril 3 can also have a protruding nose bridge 5 have, which increases the comfort of the mask and tends to slip less. In order to prevent slipping, the mask can have an adhesion promoter on the side facing the skin, which does not stick in the manner of an adhesive, but is only sticky and thus enables a fixation on the face.

A second embodiment of the invention is in 2 shown. This shows a dressing according to the invention, designated as a whole as 20, which is designed as a wound dressing and which is on a wound 30 one leg 40 rests.

The actual wound dressing 11 has an essentially rectangular shape. It also consists of a sponge-like material based on polymer, in particular alginate based, with a material thickness of 0.5 mm to 5 mm. The material can contain the above-mentioned active ingredients and / or cosmetics etc. On its side 15 facing the wound, the wound dressing advantageously has an adhesion promoter, so that the wound dressing can be attached to or around the wound 30 in a quasi self-adhesive manner. The tackiness and water resistance of the adhesion promoter can be varied depending on the application, from less adhesive and not water-soluble to highly adhesive and waterproof. The wound dressing too 11 can have pores spread over their area 14 so that the covered wound can be ventilated, which is important to avoid wound moisture.

Claims (15)

Edition for dermatological use containing a polymer-based carrier material, especially alginic acid base. Pad according to claim 1, characterized in that this support material spongy and / or spongy is constructed. Pad according to claim 1 or 2, characterized in that this support material Includes polysaccharides. Pad according to one of the preceding claims, characterized characterized that they contain at least one in ginseng Active ingredient and / or at least one further formulation containing active ingredient contains. Pad according to one of the preceding claims, characterized characterized that it contains skin care products and / or cosmetics. Pad according to claim 4 or 5, characterized in that the at least one active ingredient contained in ginseng and / or the at least one a further active ingredient-containing formulation and / or the skin care product and / or cosmetic at least partially to the surface of the support material is bound. Pad according to claim 6, characterized in that the at least one active ingredient contained in ginseng and / or the at least one an active ingredient-containing formulation and / or the skin care product and / or cosmetic by means of an at least partially soluble Adhesion promoter to the surface of the support material is bound. Pad according to claim 7, characterized in that the Adhesion promoter thread-like and / or tissue-like Contains substances. Edition according to one of the preceding claims 4 to 8, characterized in that the at least an active ingredient contained in ginseng and / or the at least one formulation containing the active ingredient and / or the skin care product and / or Cosmetic is at least partially introduced into the carrier material. Pad according to one of the preceding claims, characterized characterized that the support material is in compressed form. Pad according to one of the preceding claims, characterized characterized in that they are conventional auxiliary substances and / or contains additives. Use of a pad according to one of claims 1 to 11 as a face mask for dermatological use. Use of a pad according to one of claims 1 to 11 for the manufacture of a face mask for dermatological use. Use of a pad according to one of claims 1 to 11 for the production of dermatological conditions. Use of a pad according to one of claims 1 to 11 for the manufacture of dermatological wound dressings.