DE10257478A1 - Composition containing antioxidants and micronutrients, useful for treatment or prevention of paradontitis and associated disorders, also osteoporosis - Google Patents

Abstract

The application relates to a composition comprising a content of antioxidants and vital substances as well as suitable auxiliaries and carriers for the prophylactic and / or acute treatment of periodontitis as well as accompanying and / or secondary diseases associated therewith.

Description

The present invention relates to a composition for prophylactic and / or acute treatment of periodontitis as well as accompanying and / or secondary diseases.

The frequency was in Germany in 1999 requiring treatment Periodontitis in over 75% and count worldwide - after Caries - too the most common diseases.

Chronic gum infections can be the cause of various diseases. With chronic diseases Inflammatory bacteria penetrate the gums and the tooth bed also in the blood vessels. There they activate immune-competent cells of the body's defenses. On the alarmed immune cells then produce this stimulus, cytokines, i.e. destructive Messenger substances that spread to other tissues and organs throughout the organism damage can.

For example, the pancreas can be used for insulin production responsible cells damaged or permanently cytokine levels even destroyed become. If this is the case, diabetes can develop. Bacteria, such as Streptococcus sanguis or Porphyromonas gingivalis can cause serious heart disease trigger. In patients with advanced periodontitis, there was a triple Stroke risk as well as a sevenfold risk of premature birth in women observed.

Enzymes flowing out of the plaque, (e.g. hyaluronidases, collagenases and chondrioitinsulfatases) Antigens, endotoxins and cytokines interfere with the tissue. The Tissue responds with immune processes, leading to periodontitis and the formation of pathological gum pockets, for dissolution of the connective tissue with bone loss, for loosening teeth and ultimately lead to tooth loss. The insidious of this disease is that periodontitis is well advanced Stage is usually painless. The disease is due to the deterioration of the metabolism progressively and is contagious.

There is therefore a means at your disposal with which one routinely the development of periodontitis counteract prophylactically and periodontitis that has already occurred can push back to avoid complications.

Object of the present invention is accordingly a composition comprising an antioxidant content and vital substances as well as suitable auxiliary and carrier substances for prophylactic and / or acute treatment of periodontitis and related Concomitant and / or secondary diseases.

Through the combinatorial application of antioxidants and vital substances the metabolic situation in the oral area at - simultaneous suppression of inflammation - optimized. The effect is more surprising compared to the individual administration of the components Wise synergistic.

Preferably, the composition contains ubiquinone (Q10) and vital substances, namely vitamins and / or minerals. The vitamins include all common vitamins of groups A, B, C, D, E and K. Among the minerals are preferred those based on calcium, magnesium, zinc, copper, manganese, fluorine and mention phosphorus.

The antibacterial effect of polyphenols Substances (e.g. green tea extracts) cause growth inhibition of the bacterium "streptococcus mutans "for improvement the gum quality and a significant decrease in the plaque index.

Other beneficial ingredients the compositions form the amino acids, e.g. B. in aloe vera, in particular Lysine, which is an essential part of collagen, the tendons, Bones and teeth is. Lysine blocks the protein-digesting Enzymes (proteases) and thus reduces the breakdown of gums.

Find the compositions of the invention therefore preferred use in therapy for acute and chronic Gum and jaw diseases, especially with osteoporosis prevention of osteoporosis. The composition can be in the form of human and veterinary medicine of pastes, oils or in the form of lozenges.

Preferred compositions, in the form of a paste, an oil and a lozenge, are given below by way of example. paste (effective content of active ingredient per 100 g) Q10 0.001-10.0% by weight (1 mg-10 g) Vit C 0.5-15% by weight (500 mg-15 g) Vit E 0.01-10.0% by weight (10 mg-10 g) B-carotene (oil) 0.001-5.0% by weight (1 mg-5 g) Vit B5 (panthetin) 0.01-5.0% by weight (10 mg-5 g) Omega 3 FS 0-60.0 wt% (0-60 g) Vit D (Ol jecoris) 0-5.0 wt% (0-5 g) propolis 0-10.0% by weight (0-10 g) Malaleuca-alternifolia 0-5.0 wt% (0-5 g) magnesium fluoride 0-0.5% by weight (0-500 mg) zinc fluoride 0-0.1% by weight (0-100 mg) polyphenols 0-2.0% by weight (0-2 g) lysine 0-2.0% by weight (0-2.0 g) Aloe vera 0-10% by weight (0-10 g)

If appropriate, this paste composition can contain polishing agents and / or flavorings as well as carriers or binders.
Polishing agent: for example dicalcium phosphate dihydrate
Flavorings:
Sage, lemon, peppermint, menthol and / or clove oils.
Excipients / Binder:
Agar or silica, such as Aerosil ^® oil (effective content of active ingredient per 100 g) Q10 0-80% by weight 01 jecoris 0-70% by weight Vitamin E. 0-50% by weight vitamin C 0-70% by weight lozenge (effective content of active ingredient per 100 g) Q10 0–10 g or –20% Vit C 0–10 g or –10% Vit E 0–10 g or –10% mg 0-5 g or -5% polyphenols 0-5 g or -5%

The positive effects of the above specified compositions are based on a disinfection of oral and throat, a prevention of inflammation of the respiratory tract, one Support or Relief of the immune system, avoidance and reduction of one strong bad breath, support or therapy for gingivitis and, last but not least, a prophylactic and supportive one Therapy for osteoporosis, especially the jawbone.

Q10 is part of the electron transport chain, around the high-energy electrons generated during glucose cleavage neutralize and gain ATP. A lack leads to Lower ATP production and thus lower cell renewal.

Vitamin C promotes the new production of Collagen and elastin molecules. This ensures sufficient connective tissue strength.

Osteoporosis is the accelerated and premature Bone breakdown, especially of the spine, the neck of the femur and on the alveolar process of the jawbone. The disease is caused by a Decrease in bone mass and deterioration in micro-architecture of the bone. In 1999, about 6 million people suffered of osteoporosis.

Are the compositions of the invention also for the prevention of osteoporosis serve, it is advantageous further vitamins and / or vital substances add.

The effects of some of these components are briefly explained below:
Vitamin D: promotes calcium absorption in the intestine; is involved in bone metabolism; Deficits with reduced exposure to sunlight;
Vitamin D supply 1. via food; mostly too low
2. Own production in the skin with UV light.
Vitamin B6: Bone contains organic matrix, the components of which are bone fibrils. They are responsible for the elasticity of the bones.
B6 is important for the synthesis of bone collagen. There is a positive influence on the bone-building female sex hormone progesterone.
Deficiency: due to environmental toxins such as hydrazines; Various herbicides act as B6 antagonists.
Vitamin C: participation in the synthesis of bone collagen; collagen biosynthesis enhances bone stability;
Activation of vitamin D.
With vitamin C deficiency: reduced bone formation; increased bone resorption; bleeding gingiva, explained by deficient collagen synthesis;
The vitamin C concentration in special white blood cells, the so-called polymorphonuclear neutrophil granulocytes (PMN), is 10-80 times higher than in blood plasma.
The function is:
Maintenance of chemotaxis;
easier oxidation of microorganisms;
antioxidant protection of the membranes of the granulocytes against free radicals;
Vitamin K: Calcium-binding proteins are responsible for the connection between inorganic mineral salts and the organic matrix. The formation of these proteins depends on vitamin D and vitamin K. Vitamin K is therefore necessary for the calcium incorporation in the bones. Vitamin K is e.g. B. contained in aloe vera.
Calcium: main component of the inorganic bone mass as apatite crystal, responsible for the strength of the bone; Calcium absorption is reduced by foods rich in phosphates (especially sausages and meat products); Calcium excretion is intensified through the enjoyment of coffee, alcohol, cigarettes and high-salt foods
Collagen formation: Vitamin C, zinc, copper and vitamin B6 are involved in the synthesis of bone collagen.

proteins:

Adequate protein intake is for essential to build up bones:

• 1. amino acids serve in protein as starting material for the organic bone matrix
• 2. Amino acids have special functions in bone metabolism, for example Lysine for calcium absorption in the intestine and arginine to protect against osteoporosis Formation of the insulin-like growth factor I.

The first bones show alveolar process, Femoral neck and vertebral body Calcium deficits, i.e. Osteoporosis. With vitamin D and calcium is regression of the alveolar bone possible. Are dentists often the first to be able to recognize osteoporosis and thus prevention and initiate therapy in time. With the compositions according to the invention they are given a suitable remedy.

Claims (10)

Composition comprising antioxidant content and vital substances as well as suitable auxiliary and carrier substances for prophylactic and / or acute treatment of periodontitis and related Concomitant and / or secondary diseases. Composition according to claim 1, characterized by contains ubiquinone (Q10) and vital substances, namely vitamins and / or minerals. Composition according to claim 2, characterized in that the vitamins are selected from the group consisting of vitamin A, B, C, D, E and K. Composition according to claim 2 or 3, characterized in that that the minerals are selected from the group consisting of calcium, Magnesium, zinc, copper, manganese, fluorine and phosphorus exist. Composition according to one of claims 1 to 4, characterized in that it comprises at least one amino acid. Composition according to claim 5, characterized in that the amino acid Is lysine. Use of the composition according to any one of claims 1 to 6, in therapy for acute and chronic gum and jaw disease. Use of the composition according to any one of claims 1 to 6 in osteoporosis prevention. Use of the composition according to any one of claims 1 to 6 in veterinary medicine Area, especially for the treatment of periodontitis in dogs and cats. Use of the composition according to any one of claims 1 to 6 in the form of a paste, an oil or in the form of lozenges.