DE10230026A1 - Cosmetic preparation for the treatment of dry or sensitive skin - Google Patents

Abstract

The invention comprises a cosmetic preparation containing polyhydroxyalkylamine and electrolytes, such as table salt or sea salt, and / or osmolytes, such as taurine or betaine, and / or polyol, such as glycerol or inositol. DOLLAR A The cosmetic preparation restores normal skin moisture, provides long-lasting moisture and has a soothing effect on the skin.

Description

The invention includes a cosmetic Preparation containing polyhydroxyalkylamine and electrolytes, such as Table salt or sea salt, and / or osmolytes, such as taurine or betaine, and / or polyol, such as glycerin or inositol.

The cosmetic preparation provides normal skin moisture restores, provides long-lasting moisture and soothes the skin.

The skin is the largest organ of the human. You met a variety of functions, e.g. Heat regulation, sensory organ for tactile and feeling of warmth, Barrier function and above all protection against dehydration.

• – Oberhaut (Epidermis)
• – Lederhaut (Cutis, Corium, Dermis)
• – Unterhaut (Subcutis)

The skin can be divided into three histologically distinguishable layers:

• - epidermis
• - leather skin (cutis, corium, dermis)
• - subcutis

The outer layer forms the epidermis (Epidermis). As a boundary layer, it forms the actual protective cover against the Environment. With about a tenth of the total thickness, it is simultaneous the thinnest layer of the skin.

The epidermis is a stratified one Tissue in which the outer layer, the stratum corneum, which is important for the barrier function Represents part. It is worn out in contact with the environment and is therefore in a constant process of renewal, being outward continuously released fine scales and calluses from the inside Cell and lipid material is reproduced.

The dermis lies under the epidermis, which is also referred to as the corium or dermis. The main function this mesodermal connective tissue consists in the supply of the epidermis. It is formed from elastic, collagen and reticular fibers and exhibits a big Number of plasma and mast cells.

The subcutis (subcutis) exists from loose connective tissue with more or less numerous embedded Fat cells. The thickness of the subcutaneous tissue depends primarily on the nutrition from. But the genetic disposition also plays a significant role Role.

• a) Trockenheit, Rauhigkeit und Ausbildung von Trockenheitsfältchen,
• b) Juckreiz und
• c) verminderte Rückfettung durch Talgdrüsen (z.B. nach Waschen).

Chronological skin aging is caused, for example, by endogenous, genetically determined factors. The following structural damage and functional disorders occur in the epidermis and dermis due to aging, which can also fall under the term "senile xerosis":

• a) dryness, roughness and formation of dry wrinkles,
• b) itching and
• c) Reduced regreasing by sebum glands (eg after washing).

Exogenous factors, such as UV light and chemical pollutants, can be cumulatively effective and thus further damage the skin

Dry skin and desiccation eczema occur not only as a result of skin aging, but also in general many people, especially in winter. More reasons for dry and sensitive skin are excessive bathing or showers. Dry skin is particularly caused by heavy use, frequent washing or showering with soap agents, frequent contact with fat-dissolving agents, Detergents and disinfectants. Likewise, excessive fluid withdrawal, also by drinking too little, remove moisture from the skin. dry Annoy skin and desiccation eczema with itching and can about that lead to bacterial skin infections.

Dry skin loses its suppleness and smoothness, it becomes brittle and cracked and painful. The skin surface is always horny when subjected to heavy loads stronger. Dry skin then becomes more susceptible to allergic reactions. The "dry" skin appears special thin (parchment-like) and fine pored. Because of their low fat production and their poor storage capacity from moisture it also tends to sensitive reactions climatic influences and too early Wrinkling.

Dehydrated, sensitive skin shows a lack of natural Humidity factors and increased water loss. With special Dehydration can reduce the skin's water content, which is normally 30 Percent is drop below 10 percent so the skin doesn't perform its protective function can perceive more.

So far, it has been recommended as therapy against dry skin, especially when cleaning the skin, that soap-free agents are used, should bathe once a week, shower to max. Reduced 2-3 times a week. Moisturizing bath additives should be used as a bath additive. After bathing or Showering must be dabbed off the skin and rubbed in with moisturizing creams or acid syndets.

Out DE-A1-2421618 are known skin care and skin protection agents containing skin moisturizers. These humectants are di- and / or polyhydroxyalkylamines or their salts. In addition, the skin protection agents are only provided with customary cosmetic ingredients, such as emulsifiers, fats, solvents, fragrances, thickeners and / or preservatives.

There are also other skin moisturizers, so-called moisturizers known. Fabrics or Mixtures of substances referred to which cosmetic or dermatological Give preparations the property after application or Spread on the skin surface the release of moisture from the horny layer (also transepidermal water loss (TEWL)) and / or hydration of the To influence the horny layer positively.

Known moisturizers are e.g. Glycerol.

In EP-A1-1075835 compositions with propane diol derivatives as anti-aging agents are disclosed. In addition to numerous other constituents in the formulations, glycerine is also present in a maximum amount of 1% by weight, based on the total composition. From the examples disclosed, it is clear that glycerin is not a mandatory component of the skin protection agent. An amount of more than 1% by weight of glycerin is not disclosed.

Disadvantage of the known skin moisturizers is an inadequate long-term effect and a sticky feeling on the skin.

A larger amount than 1% by weight of glycerin is due to the higher So far, stickiness has not been useful in the prior art considered.

It was therefore the task of the present one Invention to provide a cosmetic preparation that the Disadvantages of the prior art remedies. In particular it is Object of the present invention is a cosmetic preparation ready to provide the higher one and longer water storage capacity compared to known skin moisturizers generated and the sensation in the distribution on the skin is pleasant, not sticky and easy to use is.

The tasks are solved by a cosmetic preparation according to claim 1 and 3. Subject of subclaims are advantageous embodiments of the preparations according to the invention. Of the invention further comprises the use of such preparations.

• – 0,5–10 Gew.% Polyhydroxyalkylamin der Formel NR₁R₂R₃ , wobei R₁ = Mono-, Di- oder Trihydroxyalkylrest mit einer Kohlenstoffkette C₂-C₆, R₂, R₃ = H, Alkylrest mit einer Kohlenstoffkette C₁-C₁₈ oder Mono-, Di- oder Trihydroxyalkylrest mit einer Kohlenstoffkette C₂-C₆, oder deren Salze sind,
• – 0,1–10 Gew.% Elektrolyt und/oder Osmolyt und/oder
• – mehr als 1 Gew.% bis zu 10 Gew.% Polyol,

die Nachteile des Standes der Technik vermeidet. Die synergistische Kombination von 0,5–10 Gew.% Polyhydroxyalkylaminen mit 0,1–10 Gew.% Elektrolyten und/oder Osmolyten und/oder mehr als 1 Gew.% Polyolen führt zu einer Zubereitung, die hinsichtlich der Hautbefeuchtungsleistung unübertroffen ist und zudem eine gute Sensorik aufweist.It was surprising and unforeseeable for a person skilled in the art that a preparation is comprehensive

• - 0.5-10% by weight of polyhydroxyalkylamine of the formula NR ₁ R ₂ R ₃ , where R ₁ = mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , R ₂ , R ₃ = H, alkyl radical with a carbon chain C ₁ -C ₁₈ or mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , or their salts,
• - 0.1-10% by weight of electrolyte and / or osmolyte and / or
• - more than 1% by weight up to 10% by weight polyol,

avoids the disadvantages of the prior art. The synergistic combination of 0.5-10% by weight of polyhydroxyalkylamines with 0.1-10% by weight of electrolytes and / or osmolytes and / or more than 1% by weight of polyols leads to a preparation which is unsurpassed in terms of skin moisturizing performance and moreover has good sensors.

A cosmetic preparation also leads with 0.5-10 % By weight of polyhydroxyalkylamine and 0.1-10% by weight of electrolyte or osmolyte alone to an unexpectedly elevated Skin water retention.

According to the invention, the cosmetic according to the invention advantageously contains Preparation 0.5 to 10.0% by weight, particularly preferably from 1 to 5.0 % By weight of polyhydroxyalkylamines, in each case based on the total weight the preparation.

As a preferred polyhydroxyalkylamine 1-Amino-2,3-propanediol and / or 2-Amino-1,3-propanediol (Serinol) should be considered. As well can the salts of the polyhydroxyalkylamines, especially the lactates, as be considered particularly preferred.

Advantageously according to the invention, the cosmetic preparation contains electrolytes in a proportion of 0.1 to 10% by weight, particularly preferably 1 to 5% by weight and / or organic osmolytes in a concentration of 0.1 to 10% by weight, particularly preferably 0.3 -1% by weight and / or polyols in a concentration of more than 1% by weight and up to 10% by weight, particularly preferably 2 to 5% by weight, in each case based on the total weight the preparation.

Diols are preferred as polyols or low C number polyols and their ethers, preferably propylene glycol, Glycerin, butylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or -monobutyl ether, diethylene glycol monomethyl or monoethyl ether and called analog products. Have also particularly preferred Inositol, sorbitol and mannitol as polyols according to the invention proved.

Instead of or in addition, other known moisturizers can also be used are used, such as lactic acid and / or lactates, in particular Sodium lactate, butylene glycol, propylene glycol, Biosaccaride Gum-1, Glycine soy, ethylhexyloxyglycerin, pyrrolidone carboxylic acid and Urea.

Furthermore, it is particularly advantageous polymeric moisturizer from the group of water-soluble and / or in water swellable and / or polysaccharides that can be gelled with the aid of water to use. Hyaluronic acid and chitosan, for example, are particularly advantageous and / or a fucose-rich polysaccharide, which is described in Chemical Abstracts filed under registration number 178463-23-5 and z. B. under the name Fucogel®1000 by the company SOLABIA S.A. is available.

Moisturizers, e.g. Polyols the advantage that they are also beneficial as anti-wrinkle agents for the prophylaxis and treatment of cosmetic or dermatological skin lesions, as they e.g. B. occur in skin aging, can be used.

The electrolytes according to the invention are NaCl (rock salt), Sea salt and / or aqueous Chloride solution too call.

As osmolytes, for example Taurine and / or betaine understood.

The preparation according to the invention can advantageously be conventional cosmetic Contain auxiliaries, such as alcohols, in particular such a low C number, preferably ethanol and / or isopropanol, Polymers, foam stabilizers and in particular one or more Thickening agent, which or which are advantageously chosen can from the group silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g. B. hyaluronic acid, xanthan gum, cellulose ether such as. Hydroxypropylmethylcellulose, particularly advantageous the group of polyacrylates, preferably a polyacrylate from the group the so-called Carbopole [from Bf. Goodrich], for example Carbopole types 980, 981, 1382, 2984, 5984, ETD 2001, ETD 2020, ETD 2050, Ultrez 10, each individually or in combination.

Furthermore, the preparation can further advantageously contain cosmetic substances, although not necessarily, fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, cause or intensify a velvety or silky feeling on the skin. Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like), pigments which have neither mainly UV filter nor coloring effects (such as e.g. B. boron nitride etc.) and / or Aerosile ^® (CAS No. 7631-86-9).

The preparations according to the invention can be advantageous in the form of an oil-in-water emulsion (O / W emulsion) available. Advantageous according to the invention According to the invention, O / W emulsifiers are preferably selected from the following Group selected: Glyceryl stearate in combination with Ceteareth-20, Ceteareth-25, Ceteareth-6 in combination with stearyl alcohol, cetylstearyl alcohol in combination with PEG-40 castor oil and sodium cetyl stearyl sulfate, triceteareth-4 phosphate, glyceryl stearate, Sodium cetyl styrene sulfate, lecithin trilaureth-4 phosphate, laureth-4 Phosphate, stearic acid, Propylene glycol stearate SE, PEG-25 hydrogenated castor oil, PEG-54 hydrogenated castor oil, PEG-6 caprylic acid / capric acid glycerides, Glyceryl oleate in combination with propylene glycol, PEG-9 stearate, PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-100 stearate, ceteth-2, ceteth-20, Polysorbate-20, Polysorbate-60, Polysorbate-65, Polysorbate-100, Glyceryl stearate in combination with PEG-100 stearate, glyceryl myristate, Glyceryl laurate, PEG-40 sorbitan peroleate, Laureth-4, ceteareth-3, isostearylglyceryl ether, cetylstearyl alcohol in combination with sodium cetyl stearyl sulfate, Laureth-23, Steareth-2, glyceryl stearate in combination with PEG-30 stearate, PEG-40 stearate, glycol distearate, PEG-22-dodecyl glycol copolymer, polyglyceryl-2-PEG-4 stearate, ceteareth-12, Ceteareth-20, ceteareth-30, Methyl glucose sesquistearate, steareth-10, PEG-20 stearate, steareth-2 in combination with PEG-8 distearate, Steareth-21, Steareth-20, Isosteareth-20, PEG-45 / dodecyl glycol copolymer, methoxy-PEG-22 / dodecyl glycol copolymer, PEG-40 sorbitan peroleate, PEG-40 sor bitperisostearate, PEG-20 glyceryl stearate, PEG-20 glyceryl stearate, PEG-8 beeswax, Polyglyceryl-2-laurate, isostearyl diglyceryl succinate, stearamidopropyl-PG-dimonium chloride phosphate, Glyceryl stearate SE, ceteth-20, triethyl citrate, PEG-20 methyl glucose sesquistearate, Glyceryl stearate citrate, cetyl phosphate, cetearyl sulfate, sorbitan sesquioleate, Triceteareth-4-phosphate, trilaureth-4-phosphate, polyglycerylmethylglucose distearate, Potassium cetyl phosphate, isosteareth-10, polyglyceryl-2-sesquiisostearate, Ceteth-10, Oleth-20, Isoceteth-20, glyceryl stearate in combination with ceteareth-20, Ceteareth-12, cetylstearyl alcohol and cetyl palmitate, cetylstearyl alcohol in combination with PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-100 stearate.

Glyceryl stearate citrate, cetearyl sulfate, ethoxylated fatty acids (PEG-40 stearate, PEG-100 stearate) and / or phosphate emulsifiers (eg cetyl) are particularly advantageous O / W emulsifiers according to the invention Phosphate) used.

bei welcher X und Y unabhängig voneinander gewählt werden aus der Gruppe H (Wasserstoff) sowie der verzweigten und unverzweigten Alkylgruppen, Acylgruppen und Alkoxygruppen mit 1–24 Kohlenstoffatomen, p eine Zahl von 0–200 darstellt, q eine Zahl von 1–40 darstellt, und r eine Zahl von 1–100 darstellt.According to the invention, the W / O emulsifier (s) can be selected from the group of silicone emulsifiers. Advantageously from the group of alkyl methicon copolyols and / or alkyl dimethicone copolyols, in particular from the group of compounds which are characterized by the following chemical structure:

in which X and Y are selected independently of one another from the group H (hydrogen) and the branched and unbranched alkyl groups, acyl groups and alkoxy groups with 1-24 carbon atoms, p represents a number from 0-200, q represents a number from 1-40, and r represents a number from 1-100.

An example of particularly advantageous in Silicone emulsifiers to be used for the purposes of the present invention are dimethicone copolyols, which are from the company Th.Goldschmidt AG under the trade names ABIL® B 8842, ABIL® B 8843, ABIL® B 8847, ABIL® B 8851, ABIL® B 8852, ABIL® B 8863, ABIL® B 8873 and ABIL® B 88183 are sold.

Another example of special surfactants to be used advantageously for the purposes of the present invention Substances is the cetyl dimethicone copolyol, which is made by society Th.Goldschmidt AG sold under the brand name ABIL® EM 90 becomes.

Another example of special surfactants to be used advantageously for the purposes of the present invention Substances is the cyclomethicone dimethicone copolyol, which by sold by Th.Goldschmidt AG under the trade name ABIL® EM 97 becomes.

It has also proven to be very special the emulsifier lauryl methicone copolyol has been found to be advantageous, which is marketed under the trademark Dow Corning® 5200 Formulation Aid by Dow Corning Ltd. is available.

Another advantageous silicone emulsifier is, octyl dimethicone ethoxy glucoside 'from Wacker.

According to the invention, the preparations according to the invention can advantageously be present as a water-in-oil emulsion. According to the invention, the W / O emulsifiers can advantageously be selected from the following group:
Sorbitan stearate, sorbitan oleate, lecithin, glyceryl ethanolate, lanolin, ozokerite, hydrogenated castor oil, glyceryl isostearate, polyglyceryl 3 oleate, wool wax acid mixtures, wool wax alcohol mixtures, pentaerythrithyl isostearate, polyglyceryl 3-ducyl stearate, polyglyceryl 3-ducyl stearate, polyglyceryl 3-di-glucose o-stearate, Hexyl laurate, acrylate / C _10-30 alkyl acrylate crosspolymer, sorbitan isostearate, poloxamer 101, polyglyceryl-2-dipolyhydroxystearate, polyglyceryl 4-dipolyhydroxystearate, PEG-30-dipolyhydroxystearate, diisostearoylpolyglyceryl-3-diisostearate, polyglyceryl-3-diisostearate, 3 dioleate.

The following combinations of lipophilic components and emulsifiers are advantageous:
Sorbitan oleate in a mixture with hydrogenated castor oil, beeswax (Cera alba) and stearic acid, sodium dihydroxycetylphosphate in a mixture with isopropylhydroxycetyl ether, methyl glucose dioleate in a mixture with hydroxystearate and beeswax, mineral oil in a mixture with petrolatum, ozokerite, glyceryl oleate, petroleum alcohol, ricinolated alcohol, with lanolin alcohol and lanolin alcohol , Glyceryl isostearate and polyglyceryl-3-oleate, sorbitan oleate in a mixture with PEG-2 hydrogenated castor oil, ozokerite and hydrogenated castor oil, sorbitan isostearate in a mixture with PEG-2 hydrogenated castor oil.

According to the invention, this becomes special advantageous as W / O emulsifiers: cetyldimethicone copolyol, glyceryl isostearate, Polyglyceryl-2-dipolyhydroxystearate and / or PEG-30 dipolyhydroxystearate used.

The cosmetic and dermatological invention Preparations can Contain dyes and / or color pigments, especially if they in the form of decorative cosmetics. It can be advantageous according to the invention the individual phases of the preparation are colored differently. Also embodiments the invention, in which only one of the two phases is colored, are advantageous according to the invention. The dyes and pigments can from the corresponding positive list of the Cosmetics Ordinance or the EC list of cosmetic colorants selected become. In most cases are you with those for Food-approved dyes identical. Advantageous color pigments Examples are titanium dioxide, mica, iron oxides (e.g.

Fe ₂ O ₃ , Fe ₃ O ₄ , FeO (OH)) and / or tin oxide. Advantageous dyes are, for example, carmine, berli Blue, chrome oxide green, ultramarine blue and / or manganese violet. It is particularly advantageous to choose the dyes and / or color pigments from the Rowe Color Index, 3rd edition, Society of Dyers and Colorists, Bradford, England, 1971.

If the formulations according to the invention in the form of products that are used on the face, is it convenient as a dye one or more substances from the following group to choose: 2,4-dihydroxyazobenzene, 1- (2'-chloro-4'-nitro-1'-phenylazo) -2-hydroxynaphthalene, ceres red, 2- (sulfo-1-naphthylazo) -1-naphthol-4-sulfonic acid, calcium salt of 2-hydroxy-1,2'-azonaphthalene-1'-sulfonic acid, calcium and barium salts of 1- (2-sulfo-4-methyl-1-phenylazo) -2-naphthylcarboxylic acid, calcium salt 1- (2-sulfo-1-naphthylazo) -2-hydroxynaphthalene-3-carboxylic acid, aluminum salt 1- (4-sulfo-1-phenylazo) -2-naphthol-6-sulfonic acid, aluminum salt 1- (4-sulfo-1-naphthylazo) -2-naphthol-3,6-disulfonic acid, 1- (4-sulfo-1-naphthylazo) -2-naphthol-6,8-disulfonic acid, aluminum salt 4- (4-sulfo-1-phenylazo) -1- (4-sulfophenyl) -5-hydroxy-pyrazolone-3-carboxylic acid, aluminum and zirconium salts of 4,5-dibromofluorescein, aluminum and zirconium salts of 2,4,5,7-tetrabromofluorescein, 3 ', 4', 5 ', 6'-tetrachloro-2,4,5,7-tetrabromofluorescein and its aluminum salt, aluminum salt of 2,4,5,7-tetraiodofluorescein, Aluminum salt of quinophthalone disulfonic acid, aluminum salt of indigo disulfonic acid, red and black iron oxide (CIN: 77 491 (red) and 77 499 (black)), Iron oxide hydrate (CIN: 77 492), manganese ammonium diphosphate and titanium dioxide.

Oil-soluble natural dyes are also advantageous, such as B. paprika extracts, beta-carotene or cochineal.

• 1. Natürliche Perlglanzpigmente, wie z. B.
• – „Fischsilber" (Guanin/Hypoxanthin-Mischkristalle aus Fischschuppen) und
• – „Perlmutt" (vermahlene Muschelschalen)
• 2. Monokristalline Perlglanzpigmente wie z. B. Bismuthoxychlorid (BiOCl)
• 3. Schicht-Substrat Pigmente: z. B. Glimmer/Metalloxid

Formulations containing pearlescent pigments are also advantageous for the purposes of the present invention. The types of pearlescent pigments listed below are particularly preferred:

• 1. Natural pearlescent pigments, such as. B.
• - "fish silver" (guanine / hypoxanthine mixed crystals from fish scales) and
• - "mother-of-pearl" (milled mussel shells)
• 2. Monocrystalline pearlescent pigments such as B. Bismuth oxychloride (BiOCl)
• 3. Layer-substrate pigments: e.g. B. mica / metal oxide

The basis for pearlescent pigments are, for example powdery Pigments or castor oil dispersions from Bismuth oxychloride and / or titanium dioxide and bismuth oxychloride and / or Titanium dioxide on mica. B. the under the CIN 77163 listed gloss pigment.

The following pearlescent pigment types based on mica / metal oxide are also advantageous:

Z are particularly preferred. B. the from Merck under the trade names Timiron, Colorona or Dichrona available Pearlescent pigments.

The list of the pearlescent pigments mentioned is of course not intended to be limiting. Pearlescent pigments which are advantageous in the sense of the present invention can be obtained in numerous ways known per se. For example, other substrates besides mica can be coated with other metal oxides, such as. B. silica and the like. Z are advantageous. B. with TiO ₂ and Fe ₂ O ₃ coated SiO ₂ particles ("Ro naspheren "), which are sold by Merck and are particularly suitable for the optical reduction of fine wrinkles.

It can also be an advantage completely to do without a substrate like mica. Particularly preferred are iron pearlescent pigments, which without the use of mica getting produced. Such pigments are e.g. B. under the trade name Sicopearl Kupfer 1000 available from BASF.

Are also particularly advantageous also effect pigments sold under the trade name Metasomes Standard / glitter in different colors (yello, red, green, blue) are available from Flora Tech. The glitter particles are in mixtures with different ones Auxiliaries and dyes (such as the dyes with the Color Index (Cl) numbers 19140, 77007, 77289, 77491).

The dyes and pigments can both available individually as well as in combination and mutually be coated, with different coating thicknesses different color effects are generally produced. The The total amount of dyes and coloring pigments is advantageous from the range of z. B. 0.1 wt .-% to 30 wt .-%, preferably from 0.5 to 15% by weight, in particular from 1.0 to 10% by weight, in each case based on the total weight of the preparations.

Advantageous preservatives for the purposes of the present invention are, for example, formaldehyde releasers (such as, for example, DMDM hydantoin, which is available, for example, from Lonza under the trade name Glydant ^™ ), iodopropyl butyl carbamates (for example those under the trade names Glycacil-L, Glycacil -S available from Lonza and / or Dekaben LMB from Jan Dekker), parabens (ie alkyl p-hydroxybenzoate such as methyl, ethyl, propyl and / or butyl paraben), phenoxyethanol, ethanol, benzoic acid and the like. According to the invention, the preservation system usually also advantageously comprises preservation aids, such as, for example, octoxyglycerol, glycine soya, etc.

Advantageous complexing agents in the sense The present invention includes, for example, EDTA, [S, S] ethylenediamine disuccinate (EDDS), which, for example, under the trade name Octaquest available from Octel is pentasodium ethylenediaminetetramethylene phosphonate, which z. B. is available under the trade name Dequest 2046 from Monsanto and / or iminodisuccinic acid, which u. a. from Bayer AG under the trade name Iminodisuccinat VP OC 370 (approx. 30% solution) and Baypure CX 100 permanently available is.

An additional content of antioxidants in the preparation is generally preferred. According to the invention as favorable Antioxidants all for cosmetic and / or dermatological applications suitable or common Antioxidants are used.

The antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, Glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters ) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g. buthioninsulfoximines, homocysteine sulfoximine, buthioninsulfones, penta-, hexa-, H eptathioninsulfoximine) in very low tolerable doses (e.g. pmol to μmol / kg), also (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid , Biliary extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) as well as coniferyl benzoate of benzoic resin, rutinic acid and its derivatives, α-glycosyl rutin, ferulic acid, furfurylidene glucitol, carnosine Butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajakarzarzäure, Nordihydroguajaretsäure, trihydroxybutyrophenone, uric acid and its derivatives, mannose and their De derivatives, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. selenium methionine), stilbenes and their derivatives (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, Nucleosides, peptides and lipids) of these active ingredients.

The amount of the aforementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 10% by weight, particularly preferably 0.05-5% by weight, in particular 0.1-2% by weight, based on the total weight of the preparation.

If vitamin E and / or its Derivatives that are antioxidants are advantageous their respective concentrations in the range of 0.001-5% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to obtain their respective concentrations in the range from 0.001-2% by weight based on the total weight of the formulation.

In addition, selected recipes according to the invention are suitable, which z. B. known anti-wrinkle agents such as flavone glycosides (especially α-glycosyl rutin), Contain coenzyme Q10, vitamin E and / or derivatives and the like, particularly advantageous for the prophylaxis and treatment of cosmetic or dermatological skin changes, as they e.g. B. skin aging (e.g. wrinkles and fine lines) occur.

If α-glycosylrutin is the antioxidant represents is advantageous, their respective concentrations from the Range from 0.001-5 % By weight, based on the total weight of the formulation.

The preparations according to the invention can be more advantageous Way contain UV filter substances. Such preparations can be advantageous used as a sunscreen in the sense of the present invention become. But also cosmetic and dermatological preparations, their main The purpose of protection from sunlight is not, but it still does Containing content of other UV protective substances make extremely advantageous according to the invention embodiments of the present invention. B. in day care products or makeup products usually UV-A or UV-B filter substances incorporated. Also provide UV protection substances, as well as antioxidants and, if desired, preservatives, an effective protection of the preparations themselves against spoilage.

Accordingly, the preparations contain in the sense of the present invention preferably at least one UV-A, UV-B and / or broadband filter substance and / or at least one UV light reflecting and / or absorbing inorganic pigment. The formulations can although not necessary, possibly one or more organic ones and / or contain inorganic pigments as UV filter substances, which can be in the water and / or oil phase.

According to the invention, all embodiments are where the UV protection substances are only in one of the two phases or are in both phases of the preparations according to the invention.

The preparations according to the invention can also also advantageous in the form of so-called oil-free cosmetic or dermatological Preparations are present which have a water phase and at least one liquid at room temperature UV filter substance included as a further phase.

Particularly advantageous at room temperature liquid UV filter substances in the sense of the present invention are homomenthyl salicylate (INCl: homosalate), 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (INCl: octocrylene), 2-ethylhexyl-2-hydroxybenzoate (2-ethylhexyl salicylate, octyl salicylate, INCl: ethylhexyl salicylate) and esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester (2-ethylhexyl-4-methoxycinnamate, INCl: ethylhexyl methoxycinnamate) and isopentyl 4-methoxycinnamate (Isopentyl 4-methoxycinnamate, INCl: isoamyl p-methoxycinnamate) and polymeric UV filters like that (3- (4- (2,2-bis-ethoxycarbonylvinyl) phenoxy) propenyl) methylsiloxane / dimethylsiloxane Copolymer, which, for example, at Hoffmann-La Roche under the Trade name Parsol SLX is available.

Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (TiO ₂ ), zinc (ZnO), iron (e.g. Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon ( SiO ₂ ), manganese (e.g. MnO), aluminum (Al ₂ O ₃ ), cerium (e.g. Ce ₂ O ₃ ), mixed oxides of the corresponding metals as well as mixtures of such oxides and the sulfate of barium (BaSO ₄ ).

The pigments can be advantageous in the sense of present invention also in the form of commercially available oily or aqueous Predispersions are used. These predispersions can be beneficial Dispersing aids and / or solubilizing agents added his.

The pigments can be advantageous according to the invention superficial treated ("coated"), for example a hydrophilic, amphiphilic or hydrophobic character is formed will or should be preserved. This surface treatment can consist of that the pigments according to known methods with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer be provided. The various surface coatings can be in According to the present invention also contain water.

Inorganic surface coatings in the sense of the present invention can consist of aluminum oxide (Al ₂ O ₃ ), aluminum hydroxide Al (OH) ₃ , or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2), sodium hexametaphosphate (NaPO ₃ ) ₆ , sodium metaphosphate (NaPO ₃ ) _n , silicon dioxide (SiO ₂ ) (also: silica, CAS No .: 7631-86-9), barium sulfate (BaSO ₄ ) or iron oxide (Fe ₂ O ₃ ). These inorganic surface coatings can occur alone, in combination and / or in combination with organic coating materials.

Organic surface coatings in the sense of the present invention consists of vegetable or animal aluminum stearate, vegetable or animal stearic acid, Lauric acid, Dimethylpolysiloxane (also: Dimethicone), methylpolysiloxane (Methicone), Simethicone (a mixture of dimethylpolysiloxane with an average chain length from 200 to 350 dimethylsiloxane units and silica gel) or alginic acid. This organic surface coatings can alone, in combination and / or in combination with inorganic Coating materials occur.

Zinc oxide particles and predispersions of zinc oxide particles suitable according to the invention are available under the following trade names from the listed companies:

Suitable titanium dioxide particles and predispersions of titanium dioxide particles are available under the following trade names from the companies listed:

Advantageous UV-A filter substances for the purposes of the present invention are Dibenzoylmethander derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS-Nr. 70356-09-) carried by Givaudan under the trade name Parsol ^® 1789 and is sold by Merck under the trade name Eusolex® 9020.

• – Phenylen-1,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonsäure und ihre Salze, besonders die entsprechenden Natrium-, Kalium- oder Triethanolammonium-Salze, insbesondere das Phenylen-1,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonsäure-bis-natriumsalz mit der INCl-Bezeichnung Disodium Phenyl Dibenzimidazole Tetrasulfonate (CAS-Nr.: 180898-37-7), welches beispielsweise unter der Handelsbezeichnung Neo Heliopan AP bei Haarmann & Reimer erhältlich ist;
• – Salze der 2-Phenylbenzimidazol-5-sulfonsäure, wie ihr Natrium-, Kalium- oder ihr Triethanolammonium-Salz sowie die Sulfonsäure selbst mit der INCl Bezeichnung Phenylberzimidazole Sulfonsäure (CAS.-Nr. 27503-81-7), welches beispielsweise unter der Handelsbezeichnung Eusolex 232 bei Merck oder unter Neo Heliopan Hydro bei Haarmann & Reimer erhältlich ist;
• – 1,4-di(2-oxo-10-Sulfo-3-bornylidenmethyl)-Benzol (auch: 3,3'-(1,4-Phenylendimethylene)-bis-(7,7-dimethyl-2-oxo-bicyclo-[2.2.1]hept-1-ylmethan Sulfonsäure) und dessen Salze (besonders die entprechenden 10-Sulfato-verbindungen, insbesondere das entsprechende Natrium-, Kalium- oder Triethanolammonium-Salz), das auch als Benzol 1-1,4-di(2-oxo-3-bornylidenmethyl-10-sulfonsäure) bezeichnet wird. Benzol-1,4-di(2-oxo-3-bornylidenmethyl-10-sulfonsäure) hat die INCl-Bezeichnung Terephtalidene Dicampher Sulfonsäure (CAS.-Nr.: 90457-82-2) und ist beispielsweise unter dem Handelsnamen Mexoryl SX von der Fa. Chimex erhältlich;
• – Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z. B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und deren Salze.
• – Hydroxybenzophenon-Derivate, wie z.B. 2-(4-Diethylamino-2-hydroxybenzoyl)-benzoic acid hexylester, welches beispielsweise von der Firma BASF unter dem Handelsnamen Uvinul® A Plus erhältlich ist.
• – Benzoxazol-Derivate, wie z.B. das 2,4-bis-[5-1(dimethylpropyl)benzossazol-2-yl-(4-phenyl)-imino]-6-(2-ethylhexyl)-imino-1,3,5-triazin (CAS-Nr.: 288254-16-0), welches beispielsweise von der Firma 3V Sigma erhältlich ist.

Advantageous further UV filter substances in the sense of the present invention are sulfonated, water-soluble UV filters, such as. B .:

• - Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts, especially the phenylene-1,4 -bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt with the INCl name Disodium Phenyl Dibenzimidazole Tetrasulfonate (CAS no .: 180898-37-7), which, for example, under the Trade name Neo Heliopan AP is available from Haarmann &Reimer;
• - Salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, potassium or triethanolammonium salt and the sulfonic acid itself with the INCl designation phenylberzimidazole sulfonic acid (CAS No. 27503-81-7), which, for example, under the Trade name Eusolex 232 is available from Merck or under Neo Heliopan Hydro from Haarmann &Reimer;
• - 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) -benzene (also: 3,3 '- (1,4-phenylenedimethylene) -bis- (7,7-dimethyl-2-oxo- bicyclo- [2.2.1] hept-1-ylmethane sulfonic acid) and its salts (especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt), which is also called benzene 1-1.4 -di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) Benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) has the INCl name Terephtalidene Dicampher Sulfonic Acid (CAS.- No .: 90457-82-2) and is available, for example, under the trade name Mexoryl SX from Chimex;
• - Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and salts thereof.
• - Hydroxybenzophenone derivatives, such as 2- (4-diethylamino-2-hydroxybenzoyl) benzoic acid hexyl ester, which is available, for example, from BASF under the trade name Uvinul® A Plus.
• Benzoxazole derivatives, such as, for example, 2,4-bis- [5-1 (dimethylpropyl) benzossazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,3, 5-triazine (CAS No .: 288254-16-0), which is available, for example, from 3V Sigma.

Advantageous UV filter substances In the sense of the present invention, so-called broadband filters are also i.e. Filter substances that contain both UV-A and UV-B radiation absorb.

• – 2,4-Bis-{[4-(2-Ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCl: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazin), welches unter der Handelsbezeichnung Tinosorb® S bei der CIBA-Chemikalien GmbH erhältlich ist;
• – Diethylhexylbutylamidotriazon (INCl: Diethylhexyl Butamido Triazone), welches unter der Handelsbezeichnung UVASORB HEB bei Sigma 3V erhältlich ist;
• – 4,4',4''-(1,3,5-Triazin-2,4,6-triyltriimino)-tris-benzoësäure-tris(2-ethylhexylester), auch: 2,4,6-Tris-[anilino-(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazin (INCl: Ethylhexyl Triazone), welches von der BASF Aktiengesellschaft unter der Warenbezeichnung UVINUL® T 150 vertrieben wird.

Advantageous broadband filters or UV-B filter substances are, for example, triazine derivatives, such as, for. B.

• - 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCl: bis-ethylhexyloxyphenol methoxyphenyl triazine ), which is available under the trade name Tinosorb® S from CIBA-Chemicals GmbH;
• - Diethylhexylbutylamidotriazon (INCl: Diethylhexyl Butamido Triazone), which is available under the trade name UVASORB HEB from Sigma 3V;
• - 4,4 ', 4''- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2-ethylhexyl ester), also: 2,4,6-tris- [ anili no- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCl: ethylhexyl triazone), which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.

An advantageous broadband filter For the purposes of the present invention, 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol) is also CAS No .: 103597-45-1, which is available under the trade name Tinosorb® M from CIBA Chemicals GmbH available is.

Advantageous broadband filter in For the purposes of the present invention, 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy ] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCl designation Drometrizole Trisilo xane, which is available under the trade name Mexoryl® XL from Chimex.

The other UV filter substances can be oil soluble or water soluble his.

• – 3-Benzylidencampher-Derivate, vorzugsweise 3-(4-Methylbenzyliden)campher, 3-Benzylidencampher;
• – 4-Aminobenzoesäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoesäure(2-ethylhexyl)ester, 4-(Dimethylamino)benzoesäureamylester;
• – Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2-Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon
• – sowie an Polymere gebundene UV-Filter.
• – 3-(4-(2,2-bis Ethoxycarbonylvinyl)-phenoxy)propenyl)-methoxysiloxan/Dimethylsiloxan – Copolymer welches beispielsweise unter der Handelsbezeichnung Parsol© SLX bei Hoffmann La Roche erhältlich ist.

Advantageous oil-soluble UV-B and / or broadband filter substances in the sense of the present invention are e.g. B .:

• - 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
• - As well as UV filters bound to polymers.
• - 3- (4- (2,2-bis-ethoxycarbonylvinyl) phenoxy) propenyl) methoxysiloxane / dimethylsiloxane copolymer which is available, for example, from Hoffmann La Roche under the trade name Parsol © SLX.

Particularly advantageous preparations in the sense of the present invention, which is characterized by a high or very high UV-A and / or UV-B protection in addition to the filter substance or substances according to the invention) furthermore preferably further UV-A and / or broadband filters, in particular dibenzoylmethane derivatives [for example the 4- (tert-butyl) -4'-methoxydibenzoylmethane], Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or their salts, the 2- (4-diethylamino-2-hydroxybenzoyl) -benzoic acid hexyl ester and / or the 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine and / or 2,4-bis- [5-1 (dimethylpropyl) benzossazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) imino-1,3,5-triazine, individually or in any combination with each other.

The list of UV filters mentioned, which can be used within the meaning of the present invention Of course not be limiting.

The UV light protection filter advantageous according to the invention are preferred in a concentration of 0.1 to 30% by weight, especially in a concentration of 0.5 to 15% by weight on the total weight of the formulation.

The sun protection preparations advantageous according to the invention contain asymmetrically substituted triazines as organic filters, Bisimidazylates and / or benzotriazoles.

Furthermore, it can be from Be an advantage of film formers in the cosmetic or dermatological invention Incorporate preparations, for example to ensure water resistance of the preparations or to increase the UV protection performance (UV-A and / or UV-B boosting). Both water-soluble or dispersible as well as fat-soluble Film formers, individually or in combination with each other.

Advantageous water-soluble or dispersible film formers are e.g. B. Polyurethanes (e.g. the Avalure® types from Goodrich), Dimethicone Copolyol Polyacrylate (Silsoft Surface® by der Witco Organo Silicones Group), PVP / VA (VA = vinyl acetate) copolymer (Luviscol VA 64 Powder from BASF) etc.

Advantageous fat-soluble film formers are e.g. B., the film formers from the group of polymers based on polyvinylpyrrolidone (PVP)

Copolymers are particularly preferred of polyvinylpyrrolidone, for example the PVP hexadecene copolymer and the PVP eicosen copolymer, which is available under the trade names Antaron V216 and Antaron V220 at the GAF Chemicals Cooperation available are, as well as the Tricontayl PVP and the like.

According to the invention, the cosmetic and / or dermatological preparations according to the invention can be composed as usual and the cosmetic and / or dermatological light protection, further ner for the treatment, care and cleaning of the skin and / or hair and as a make-up product in decorative cosmetics.

It is also advantageous according to the invention if in the preparations according to the invention Thickeners can be used. These can be advantageous, for example chosen from the group of gums become.

Gums include plant or tree sap that harden in the air and form resins or extracts from aquatic plants. From this group can can advantageously be chosen for the purposes of the present invention e.g. gum arabic, carob flour, tragacanth, karaya, Guar gum, pectin, gellan gum, carrageenan, agar, algine, chondrus, Xanthan gum.

The use is also advantageous of derivatized gums such as Hydroxypropyl guar (jaguars HP 8).

Among the polysaccharides and derivatives are e.g. hyaluronic acid, Chitin and chitosan, chondroitin sulfates, starch and starch derivatives are advantageous according to the invention Thickener.

Located among the cellulose derivatives e.g. Methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, Hydroxypropylmethylcellulose as an advantageous thickener according to the invention.

Located under the layered silicates yourself, of course existing and synthetic clays such as Montmorillonite, bentonite, Hectorite, laponite, magnesium aluminum silicates such as Veegum®. These can be as such or used in modified form as a thickener such as. Stearylalkonium hektorite.

Silica gels can also be used advantageously be used.

Located under the polyacrylates e.g. Carbopol types from Goodrich (Carbopol 980, 981, 1382, 5984, 2984, ETD 2001, ETD 2020, ETD 2050 or Pemulen TR1 & TR2).

Among the polymers are e.g. Polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP / VA Copolymers, polyglycols and ammonium acryloyldimethyltaurate / VP Copolymer.

In the preparations according to the invention can but also other pharmaceutically or dermatologically active substances such as skin soothing and nourishing substances be incorporated. Which includes for example panthenol, allantoin, tannin, antihistamines, antiphlogistics, Glucocorticoids (e.g. hydrocortisone) as well as plant substances such as Azulene and bisabolol, glycyrrhizin, hamamelin and plant extracts such as chamomile, aloe vera, hamazelis, licorice root.

Accordingly, cosmetic and / or topical dermatological compositions in the sense of the present invention, depending on their structure, for example used as a skin protection cream, cleansing milk, Sunscreen lotion, hand cream, nutrient cream, daily or night cream, Cleansing gels, toners, Stick preparations, etc. It may be possible and advantageous that compositions according to the invention as the basis for to use pharmaceutical formulations.

The cosmetic are used and dermatological preparations according to the invention in the usual for cosmetics Sufficiently applied to the skin and / or hair

The following examples demonstrate the synergy effect of the preparations according to the invention compared to the individual components.

example I :

Three aqueous preparations were made. Preparation A contains only 10% by weight glycerol, preparation B according to the invention contains 10% by weight serinol (2-amino-1,3-propanediol) and lactic acid in order to adjust the preparation to pH 7.0 and contains preparation C according to the invention 10% by weight of serinol and hydrochloric acid to adjust the preparation to pH 7.0. The influence of glycerol and serinol in combination with electrolytes on the moisture content of cellulose nitrate membranes was then investigated by applying the preparations to cellulose nitrate membranes and the moisture content after 20 min using the CM 825 ^® corneometer from Courage + Khazaka (Cologne, Germany ) were measured. The data correspond to the mean +/- SD (n = 3). The results are in 1 shown.

It turns out that the preparations according to the invention a much higher one Generate moisture content.

Example II:

Three preparations were produced, preparation A containing no humectants, preparation B containing 5% by weight glycerol and preparation C according to the invention containing 2% by weight serinol and 3% by weight glycerol. The influence of Serinol in combination with glycerin on the moisture content was examined. For this purpose, the preparations with the stated content of glycerol and / or serinol were used for 2 hours and the moisture content was determined using the Corneometer CM 825 ^® from Courage + Khazaka (Cologne, Germany). The data correspond to the mean values +/- SD (n = 4). The results are in 2 shown.

Preparation C also produces a higher moisture content here than the comparative additives preparations. However, it is surprising that the synergistic combination of 3% glycerin with 2% serinol in relation to 5% pure glycerin gives better results.

Example III

Three preparations were prepared, preparation A being an aqueous solution with 10% glycerol, preparation B 10% sodium chloride and preparation C 10% serinol with hydrochloric acid in order to adjust the preparation to pH 7.0. The influence of Serinol in combination with electrolytes on the water storage capacity of cellulose nitrate membranes was investigated. For this purpose, the preparations were placed on cellulose nitrate membranes and the moisture content was measured after 5 and 60 minutes using the CM 825 ^® corneometer from Courage + Khazaka (Cologne, Germany). The data correspond to the mean +/- SD (n = 3). The results are in 3 shown.

It is clearly evident that the combination according to the invention of Serinol with chloride ions an almost complete storage of water over 60 min allows.

Using other examples, it was found that also the combination of polyols and osmolytes, of polyols and electrolytes and of osmolytes and electrolytes in the preparation according to the invention an elevated Water storage compared to the individual components leads.

The following are cosmetic according to the invention Preparations listed as examples, all of which are described Benefits generate high and long-lasting skin moisture retention.

1. PIT emulsions

2. Examples of O / W cream

5. Examples of W / O emulsions

6. Examples of hydrodispersions

7. Example (gel cream):

Example 8 (W / O cream)

Example 9 (W / O / W cream):

Claims (15)

Cosmetic preparation comprising - 0.5-10% by weight of polyhydroxyalkylamine of the formula NR ₁ R ₂ R ₃ , where R ₁ = mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , R ₂ , R ₃ = H, alkyl radical with a carbon chain C ₁ -C ₁₈ or mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , or their salts, - 0.1 to 10% by weight of electrolyte and / or - 0.1 to 10% by weight of organic osmolyte and / or - more than 1% by weight to 10% by weight of polyol. Preparation according to claim 1, characterized in that 2 - 5 wt.% Polyol are included. Cosmetic preparation comprising - 0.5-10% by weight of polyhydroxyalkylamine of the formula NR ₁ R ₂ R ₃ , where R ₁ = mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , R ₂ , R ₃ = H, alkyl radical with a carbon chain C ₁ -C ₁₈ or mono-, di- or trihydroxyalkyl radical with a carbon chain C ₂ -C ₆ , or their salts, - 0.1 to 10% by weight of electrolyte and / or - 0.1 to 10% by weight of organic osmolyte Preparation according to claim 1, 2 or 3, characterized in that that the preparation 1-5 % By weight of polyhydroxyalkylamine. Preparation according to one of the preceding claims, characterized characterized in that the preparation 0.5-5 wt.% Electrolyte and / or 0.1-5 % By weight of osmolyte. Preparation according to one of the preceding claims, characterized characterized in that as polyhydroxyalkylamine 2-amino-1,3-propanediol or 1-amino-2,3-propanediol or its salts is contained. Preparation according to one of the preceding claims, characterized characterized in that one or more salts of the alkali or alkaline earth metals are included. Preparation according to one of the preceding claims, characterized characterized that as the electrolyte sodium chloride or sea salt is included. Preparation according to one of the preceding claims, characterized characterized as containing taurine and / or betaine as the osmolyte is. Preparation according to one of the preceding claims, characterized characterized in that glycerol is contained as the polyol. Preparation according to one of the preceding claims, characterized characterized in that as polyol inositol and / or sorbitol and / or Mannitol is included. Preparation according to one of the preceding claims comprising O / W emulsifiers. Preparation according to one of claims 1 to 11 comprising W / O emulsifiers. Preparation according to one of the preceding claims comprising Antioxidants, especially vitamin A, vitamin E and / or their Derivatives, carotenes, flavone glycosides and / or coenzyme Q10. Use of preparations according to one of claims 1 to 14 as a skin protection agent.