DE102024106817A1 - Composition for prophylactic and/or therapeutic treatment - Google Patents

Abstract

The present invention relates to a composition for the prophylactic and/or therapeutic treatment of bladder infections (cystitis), kidney infections (pyelonephritis), bacterial vaginal infections (vaginosis), hematuria, interstitial cystitis, restless leg syndrome, premenstrual syndrome (PMS), loss of libido, anal eczema, hemorrhoids and/or urethritis as well as dermatitis, herpes, skin diseases and/or skin irritations.

Description

Brief description of the invention

The present invention relates to a composition for the prophylactic and/or therapeutic treatment of bladder infections (cystitis), kidney infections (pyelonephritis), bacterial vaginal infections (vaginosis), hematuria, premenstrual syndrome (PMS), interstitial cystitis, restless leg syndrome, loss of libido, anal eczema, hemorrhoids and/or urethritis as well as dermatitis, herpes, skin diseases and/or skin irritations.

The diseases described above are usually triggered by inflammation, which, depending on the type of inflammation, can be caused by a bacterial infection, fungi, viruses, or other pathogens. The most common cause of cystitis, for example, is Escherichia coli bacteria, which are part of the natural human intestinal flora. However, other pathogens that can cause cystitis can also include Proteus mirabilis, staphylococci, streptococci, Klebsiella, fungi such as Candida albicans, as well as viruses or parasites, as previously mentioned.

To kill the pathogens and/or combat the inflammation, antibiotics containing active ingredients such as fosfomycin or nitrofurantoin, or antifungals, are usually prescribed. Pain relievers or antispasmodics such as ibuprofen or butylscopolamine are also used. Phytopreparations, i.e., medicinal plants such as nasturtium, horseradish root, or restharrow, are also used for their antibiotic properties, but in many cases, their effectiveness is insufficient.

The disadvantage of conventional methods, especially the use of antibiotics, is that antibiotics themselves can lead to changes in the intestinal flora and thus negatively impact the body's own defense mechanisms. Furthermore, the increased use of antibiotics leads to bacterial resistance, which can render the antibiotics ineffective over time. The disadvantage of natural preparations is that they are insufficiently effective in alleviating the corresponding symptoms and preventing inflammation.

Other preventative products, such as those used to treat cystitis, include tablets, powders, or syrups containing D-mannose, cranberry, or bearberry leaves, as well as intimate gels, which are said to have a bactericidal effect due to the alcohol or silver compounds they contain, and are also water-based or water-soluble. The disadvantage of these gels or creams is that their ingredients can disrupt the intimate flora and/or, due to their water content, cannot achieve a barrier effect. Studies have also shown that tablets, powders, or syrups do not provide sufficient protection against inflammation.

The object of the present invention is therefore to provide a composition that can effectively prevent and/or treat cystitis, pyelonephritis, bacterial vaginal infections (vaginitis), anal eczema, interstitial cystitis, restless leg syndrome, hemorrhoids, and/or urethritis without the disadvantages of the prior art agents. The same applies to the treatment of dermatitis, herpes, skin diseases, and/or skin irritations, which are usually treated with medication.

• 0,5% - 5 % Himbeersamenöl;
• 16% bis 30% Wachs;
• 45% bis 83,5 % weitere Öl-, Fett- und/oder Paraffinkomponente;
• 0% bis 20% eines Zusatzes.

The present invention therefore relates to a composition for the prophylactic and/or therapeutic treatment of bladder infections (cystitis), pyelonephritis, bacterial vaginal infections (vaginitis), hematuria, interstitial cystitis, restless leg syndrome, premenstrual syndrome (PMS), loss of libido, anal eczema, hemorrhoids and/or urethritis, dermatitis, herpes, skin diseases and/or skin irritations, consisting of an oil or fat/wax mixture, comprising

• 0.5% - 5% raspberry seed oil;
• 16% to 30% wax;
• 45% to 83.5% additional oil, fat and/or paraffin components;
• 0% to 20% of an additive.

In one aspect of the invention, the further oil, fat and/or paraffin component is apricot kernel oil, babassu oil, peanut oil, safflower oil, rosehip oil/wild rose oil, sunflower oil, thistle oil, avocado oil, walnut oil, rapeseed oil, almond oil, argan oil, grape seed oil, cottonseed oil, hemp oil, soybean oil, linseed oil, castor oil, evening primrose oil, sea buckthorn oil, wheat germ oil, moringa oil, corn germ oil, coconut oil, shea butter, clove oil, sesame oil, St. John's wort oil, calendula oil, olive oil, cocoa butter, preferably St. John's wort oil, calendula oil, hemp oil, apricot kernel oil, soybean oil, babassu oil, peanut oil, safflower oil, linseed oil, raspberry seed oil, rosehip oil/wild rose oil, sunflower oil, thistle oil, avocado oil, olive oil, walnut oil, rapeseed oil, almond oil, Argan oil, sea buckthorn oil, grape seed oil, sesame oil, cottonseed oil, and/or wheat germ oil, preferably a mixture of refined oils and cold-pressed oils. In a particularly preferred aspect, the additional oil, fat, and/or paraffin component comprises a proportion of cold-pressed oils of 30% to 75%.

The at least one wax in the composition is preferably beeswax, china wax and preen gland fat, insect wax, sugarcane wax, carnauba wax, jojoba wax, cork wax, guaruma wax (Calathea lutea), ouricuri wax (Syagrus coronata), Cuban palm wax (Copernicia hospita), esparto wax (Lygeum spartum, Stipa tenacissima), wool wax, rice bran wax, flax wax, peat wax, rose wax, jasmine wax, myrtle wax (Myrica cerifera), wax fig wax (Ficus variegata), and/or semi-synthetic waxes from vegetable oils. In a preferred aspect of the invention, the wax content is 22% to 26%.

Unlike known gels or creams, the composition in a particularly preferred embodiment does not contain any added water and/or a water-soluble compound.

As an additive, the composition may in one aspect comprise further natural ingredients, preferably vitamins, fruit powder, vegetable powder, plant powder, oil extracts and/or essential oils, or even medications.

• 0,5% bis 5 % Himbeersamenöl, vorzugsweise 1% bis 3 % Himbeersamenöl, 16% bis 30% Bienenwachs, vorzugsweise 22% bis 26%;
• 45% bis 83,5 % einer Mischung aus Arganöl, Traubenkernöl, Sojaöl, Aprikosenkernöl, Hagebuttenöl, Johanniskrautöl, Calendulaöl, Distelöl, Avocadoöl und Hanföl;
• 0% bis 10% eines Vitamins, Obstpulvers, ätherischen Öles, eines Ölauszuges, Gemüsepulvers und/oder Pflanzenpulvers;
• 0% bis 10 % eines Medikaments.

In a preferred aspect of the invention, the composition comprises the following components:

• 0.5% to 5% raspberry seed oil, preferably 1% to 3% raspberry seed oil, 16% to 30% beeswax, preferably 22% to 26%;
• 45% to 83.5% of a blend of argan oil, grape seed oil, soybean oil, apricot kernel oil, rosehip oil, St. John's wort oil, calendula oil, safflower oil, avocado oil and hemp oil;
• 0% to 10% of a vitamin, fruit powder, essential oil, oil extract, vegetable powder and/or plant powder;
• 0% to 10% of a drug.

Furthermore, the present invention relates to the use of a previously described composition in a method for the prophylactic and/or therapeutic treatment of cystitis, pyelonephritis, bacterial vaginal infections (vaginosis), interstitial cystitis, restless leg syndrome, anal eczema, hematuria, premenstrual syndrome (PMS), loss of libido, hemorrhoids and/or urethritis, dermatitis, herpes, skin diseases, and/or skin irritations, comprising applying an effective amount of the composition to the affected area. In a preferred aspect, the composition is applied in a layer of 1 mm to 5 mm, thereby forming a water-insoluble layer. Application is carried out with at least one finger and/or a cloth to the clean and dry region, with the process being repeated as needed.

The object is achieved in particular by a composition according to patent claim 1 and use with the features of claim 9. Advantageous embodiments with expedient further developments of the invention are specified in the remaining claims.

Detailed description of the invention

The present invention relates to a composition for the prophylactic and/or therapeutic treatment of cystitis, pyelonephritis, bacterial vaginal infections (vaginitis), interstitial cystitis, restless leg syndrome, anal eczema, hematuria, premenstrual syndrome (PMS), loss of libido, hemorrhoids and/or urethritis, as well as dermatitis, herpes, acne and/or limb pain. The composition is used in particular for the treatment, prevention, elimination, alleviation and/or improvement of the indications described above, which are generally associated with painful and/or inflammatory conditions, such as inflammation, secretions and/or itching.

In the following, the articles “a” and all derivatives thereof, as used herein, should generally be understood as “one or more”, unless otherwise stated or clear from the context as the singular form.

When the terms “includes,” “has,” “possesses,” and the like are used in the description or claims, these terms should be understood in the same way as the term “comprising” or “having,” i.e., not exhaustive, unless explicitly stated.

The terms "fat" and "oil" are used below. These refer to esters of propane-1,2,3-triol, also known as glycerin, with several identical or different aliphatic monocarboxylic acids, also known as fatty acids. Oils of the present invention refer to so-called fatty oils, i.e., fats that are liquid at room temperature. These are preferably vegetable and animal oils. Corresponding fats and oils include, but are not limited to, apricot kernel oil, babassu oil, peanut oil, safflower oil, raspberry seed oil, rosehip oil/wild rose oil, sunflower oil, safflower oil, avocado oil, walnut oil, rapeseed oil, almond oil, argan oil, grapeseed oil, cottonseed oil, hemp oil, soybean oil, linseed oil, castor oil, evening primrose oil, sea buckthorn oil, wheat germ oil, moringa oil, corn germ oil, coconut oil, shea butter, clove oil, sesame oil, St. John's wort oil, calendula oil, olive oil, cocoa butter, tea tree oil, rockrose oil and/or geranium. However, experiments with different fats and oils have shown that cocoa butter, coconut oil, babassu oil, and/or shea butter, alone or in combination, have a solid consistency at room temperature, making it impossible to create a composition that, along with the addition of at least 16% wax, is firm and sticky enough to prevent the above-mentioned indications, especially cystitis. These oils can still be used when blended with other oils to benefit from their solid consistency.

When selecting oils, in addition to tolerability, the comedogenicity of the oil is an important criterion. The higher the comedogenicity level of the oil, the less suitable it is for the intimate area, as it promotes the formation of comedones. The same applies when using the composition for skin irritations, for example, on the face. Therefore, oils with a maximum comedogenicity of 3, particularly preferably 0 to 2, are preferably used in the composition, as otherwise irritations, pimples, and eczema are encouraged, which should be avoided.

Furthermore, the term “paraffin” includes liquid and/or solid mixtures of saturated hydrocarbons, such as Paraffinum perliquidum, Paraffinum subliquidum and/or Paraffinum solidum.

The terms "wax" or "waxes" in the present invention refer to naturally occurring waxes that may be formed from a mixture of various hydrocarbons, with animal and vegetable waxes being particularly used in the present invention. The main components of these mixtures are esters of fatty acids with long-chain, aliphatic, primary alcohols. Examples of such waxes include, but are not limited to, the following: beeswax, china wax and preen gland fat, insect wax, sugarcane wax, carnauba wax, jojoba wax, cork wax, guaruma wax (Calathea lutea), ouricuri wax (Syagrus coronata), Cuban palm wax (Copernicia hospita), esparto wax (Lygeum spartum, Stipa tenacissima), wool wax, rice bran wax, flax wax, peat wax and rose wax, jasmine wax, myrtle wax (Myrica cerifera), and wax fig wax (Ficus variegata). Alternatively, semi-synthetic waxes, particularly those made from vegetable oils, such as rapeseed wax, soy wax, and/or sunflower wax, can be used. These waxes are hydrogenated by hydrogenating vegetable oils to achieve fat hardening. These types of waxes can also be used to produce vegan formulations. Waxes are one of the main components within the formulation.

Compositions with less than 16% wax content led to the onset of cystitis within a few days, so the wax content of the composition must be at least 16% or more, preferably at least 19%. However, the wax content depends on the component mixture of the respective oil and the corresponding wax.

The terms “intimate area” and “intimate region” are used interchangeably and in the present invention refer to the genital organs such as the penis, the testicles, the vulva and the Perineum, urethral opening, anus. In summary, the term refers to the area or region between the anus and the genitals, including the genitals. Although the following outlines the use of the composition using women as an example, as they are more frequently affected by urinary tract infections, it can also be used in men.

Cystitis, pyelonephritis, bacterial vaginal infections (vaginitis), anal eczema, interstitial cystitis, restless leg syndrome, hematuria, hemorrhoids, and/or urethritis can be caused by various factors, including physiological and anatomical causes, hygiene, fluid intake, sexual intercourse, and infections, fungi, viruses, or other pathogens. However, the most common cause is the transmission of pathogens from the anus. In the case of cystitis, this is the transmission of Escherichia coli from the anus to the urethra. Due to modern hygiene practices, such as the use of toilet paper, soap, and cleansing gels, as well as hormonal changes, such as menopause in women, the protective sebum layer in the pubic area, especially the vagina in women, is broken down or completely absent. Without this natural protective barrier, bacteria, fungi, and viruses can more easily travel from the anus to the vagina and/or urethra. This is often a major problem, particularly for women, where the urethra, vagina, and anus are located within a very small area of 1.5 to 2 cm. Improper hygiene after a bowel movement, tight clothing, sexual intercourse, and/or a visit to the swimming pool can also contribute to fecal residue being loosened at the anus through friction or water, allowing bacteria, fungi, and viruses to migrate from the anus to the urethra and/or vagina. Intimate lotions, gels, and oils that are too runny in consistency and contain a proportion of water can further encourage the migration of bacteria, viruses, and fungi. For this reason, some intimate gels and lotions contain chemical bactericidal substances to prevent bacterial growth; however, these substances attack the natural intimate flora. If the bacteria reach the urethra and/or the vagina, their proliferation increases and they continue to ascend upwards, which can generate inflammation of the tissue, ureter, kidneys and/or uterus.

To prevent such transmission of pathogens within the intimate area, a composition for application between the pubic area and the anus was developed. This composition consists of a fat, oil, or paraffin and wax mixture containing at least 16% wax. The composition contains no water content, which further minimizes the transmission of bacteria. Experimental studies with compositions below this range were unable to effectively prevent cystitis. However, if the composition had a wax content of 16% to 30%, preferably 19% to 25%, cystitis could be treated preventively, and the composition could be easily applied to the intimate area without dissolving during use or movement. In this context, the composition according to the invention consists of 16% to 30% of a wax and 70% to 84% of a fat, oil, and/or paraffin. The use of raspberry seed oil proved to be an essential component. In a particularly preferred embodiment, the composition comprises 25% of a wax and 70% to 75% of a fat, oil and/or paraffin and optionally 0 to 5% of another additive, such as at least one vitamin, fruit powder, essential oil, oil extract, vegetable powder, plant powder and/or medicament.

The composition is designed to form a waterproof layer and thus a protective barrier in the intimate area. To this end, the composition has a balanced density, melting point, and viscosity based on oils and waxes, allowing it to be applied in a thin layer to the inner pubic area, perineum, and anus, forming an adhesive barrier. The composition is said to be viscous and sticky, particularly below a temperature of 42°C (degrees Celsius), which corresponds to maximum body temperature, and also not to melt. The effectiveness of the composition is primarily due to its physical properties and not its chemical composition. Applying the composition to the intimate area, especially the anus, is essential for preventing the previously described indications, as it specifically prevents the transmission of Escherichia coli. At the same time, the anhydrous and water-insoluble formula naturally inhibits the growth of bacteria in the anus, as bacteria require a hydration of 0.98 to multiply. Consequently, due to its composition, the bacteria in the anus and/or vaginal area are encapsulated and cannot mix with the fluids from the urethra and/or vagina.

However, the composition also demonstrated a positive effect when used for dermatitis, herpes, and other skin diseases or skin irritations, such as pimples. Although the causes of skin diseases are diverse, they generally all involve a disruption of the skin barrier, so that fungi, bacteria, and/or viruses can more frequently trigger skin diseases. The present composition, comprising raspberry seed oil as at least one oil component, could protect the skin and led to skin regeneration within a short period of time, preferably within 24 to 48 hours, due to a herpes infection or dermatitis, and reduced itching within a few minutes, preferably within 5 to 60 minutes. The composition according to the invention therefore had an effect on inflammation caused by bacteria, fungi, viruses, or other pathogens, for example, as a face cream for skin irritations such as acne, or as a lip balm for herpes. In babies and toddlers, the composition, in the form of a diaper cream, has been observed to have a positive effect on diaper dermatitis.

By selecting additional oil or fat components to complement raspberry seed oil, a greater anti-inflammatory and antibacterial effect of the composition can be achieved. Examples of suitable oils include, but are not limited to, argan oil, grape seed oil, soybean oil, apricot kernel oil, St. John's wort oil, calendula oil, olive oil, sea buckthorn oil, hemp oil, almond oil, cottonseed oil, safflower oil, avocado oil, wheat germ oil, walnut oil, sunflower oil, rosehip oil, peanut oil, and/or essential oils such as tea tree oil, cistus oil, and/or geranium.

Experiments using raspberry seed oil combined with rosehip oil and a wax content of 16% to 30% also showed a positive effect on premenstrual syndrome (PMS). Using the combination of the two oils within the formulation resulted in reduced bleeding and a reduction in abdominal pain.

In addition to fats, oils, paraffins and waxes, the composition may also contain other natural ingredients such as vitamins, fruit powders such as strawberry powder, essential oils, oil extracts, vegetable powders and/or plant powders.

In a further aspect of the invention, the composition may also comprise medicaments.

Experiments were conducted to test different compositions of oil/fat and wax mixtures and investigate their effectiveness in the above-described indications in patients with chronic complaints. All compositions contained a blend of oil and wax, resulting in a water-insoluble formulation that was easy to apply to the desired area, yet firm enough to prevent the applied layer from running and thus reduce and/or prevent the transmission of bacteria, viruses, and other pathogens. The wax content in the composition ranged between 16% and 30%, but preferably between 22% and 26% wax, as these compositions exhibited the best consistency.

The composition according to the invention proved to be compatible and efficient with regard to the indications and had the following components: 0.5% - 5% Raspberry seed oil, preferably 1% to 3% raspberry seed oil, 16% to 30% Beeswax, china wax and preen gland fat, insect wax, sugar cane wax, carnauba wax, jojoba wax, cork wax, guaruma wax (Calathea lutea), ouricuri wax (Syagrus coronata), Cuban palm wax (Copernicia hospita), esparto wax (Lygeum spartum, Stipa tenacissima), wool wax, rice bran wax, flax wax, peat wax and rose wax, jasmine wax, myrtle wax (Myrica cerifera), wax fig wax (Ficus variegata), rapeseed wax, soy wax and/or sunflower wax, preferably 22% to 26% beeswax, china wax and preen gland fat, insect wax, sugar cane wax, carnauba wax, jojoba wax, cork wax, guaruma wax (Calathea lutea), ouricuri wax (Syagrus coronata), Cuban palm wax (Copernicia hospita), esparto wax (Lygeumspartum, Stipa tenacissima), wool wax, rice bran wax, flax wax, peat wax and rose wax, jasmine wax, myrtle wax (Myrica cerifera), wax fig wax (Ficusvariegata), rapeseed wax, soy wax and/or sunflower wax; 45% to 83.5% further oil/fat component comprising at least one oil/fat or an oil/fat mixture of apricot kernel oil, babassu oil, peanut oil, safflower oil, raspberry seed oil, rosehip oil/wild rose oil, sunflower oil, safflower oil, avocado oil, walnut oil, rapeseed oil, almond oil, argan oil, grape seed oil, cottonseed oil, hemp oil, soybean oil, linseed oil, castor oil, evening primrose oil, sea buckthorn oil, wheat germ oil, moringa oil, corn germ oil, coconut oil, shea butter, clove oil, sesame oil, St. John's wort oil, calendula oil, olive oil, cocoa butter, tea tree oil, rockrose oil and/or geranium; 0% to 10% a vitamin, fruit powder, essential oil, oil extract, vegetable powder and/or plant powder; and 0% to 10% a drug.

In a preferred aspect of the invention, the composition comprises the following components: 0.5% to 5% Raspberry seed oil, preferably 1% to 3% raspberry seed oil, 16% to 30% Beeswax, preferably 22% to 26%; 45% to 83.5% a blend of argan oil, grape seed oil, soybean oil, apricot kernel oil, rosehip oil, St. John's wort oil, calendula oil, safflower oil, avocado oil and hemp oil; 0% to 10% a vitamin, fruit powder, essential oil, oil extract, vegetable powder and/or plant powder; 0% to 10% a drug.

In a particularly preferred aspect of the invention, the composition comprises the following components: 0.5% to 5% Raspberry seed oil, preferably 1% to 3% raspberry seed oil, 16% to 30% Beeswax, preferably 22% to 26%; 1% to 10% Argan oil; 1% to 10% grape seed oil; 1% to 10% soybean oil; 1% to 10% apricot kernel oil; 1% to 10% rosehip oil; 1% to 7.5% St. John's wort oil; 1% to 7.5% Calendula oil; 1% to 7.5% safflower oil; 0.5% to 5% avocado oil; and 0.5% to 5% Hemp oil.

Furthermore, 0% to 10% of a vitamin, fruit powder, essential oil, oil extract, vegetable powder and/or plant powder; and optionally 0% to 10% of a medicament may be provided.

The composition according to the invention demonstrated particularly effective protection against cystitis and resulting illnesses. The composition according to the invention demonstrated an effect on cystitis after just 10 to 25 minutes of application and achieved its maximum effect by reducing it after 60 to 180 minutes, particularly 120 minutes. During this time, the number of leukocytes in the urine decreased from +500 WBC/µl to +70 WBC/µl. After 10-12 hours at the latest, the leukocytes dropped to zero. The resolution of the cystitis depended on its severity. In mild cases, healing could be observed after a shorter period. The subsequent duration of action was 10 to 16 hours, particularly 12 hours if the composition was not washed off. Due to its creamy consistency, the composition is also suitable for protecting against cracks and/or irritation, especially during sexual intercourse, and can therefore also be used as a lubricant.

The proportion of oils and fats with high bactericidal activity can be increased to enhance the effectiveness of the composition. It has been found that cold-pressed oils should represent a higher proportion in the composition than refined oils. Such an excess of cold-pressed oils increased effectiveness against transmission and infection. The proportion of cold-pressed oils should therefore preferably be between 30% and 75%, particularly preferably between 60% and 70%.

The composition is suitable for protecting women and men from infections, for example, when bedridden, after surgery, and/or after the insertion of a urinary catheter. Furthermore, the composition offers protection against infections in the genital area and/or urinary tract when visiting a swimming pool. Furthermore, ascending infections, such as cystitis and vaginosis, can be prevented in women during pregnancy without the use of antibiotics. Due to its natural composition and consistency, the composition can also be used for perineal massages, not only during pregnancy. In a further aspect of the invention, oils, fats, and/or waxes that exhibit increased coloration should be used in low concentrations or not at all, as the color can rub off on clothing. The same applies to oil-wax combinations that are too liquid, as they cannot develop an effective barrier function. The reason for this is that they run, and an adequate layer cannot be formed in the genital area. Particularly with semi-synthetic waxes made from vegetable oils, such as rapeseed wax and sunflower wax, which can be used as vegan alternatives to beeswax, rapeseed wax was found to have a reduced effect compared to beeswax because it was more liquid and dissolved more easily. Consequently, a vegan alternative to beeswax should use a combination of rapeseed wax and sunflower wax. In a preferred embodiment, a combination of 50% rapeseed wax and 50% sunflower wax should be used as a beeswax alternative.

Table 1 and Table 2 list oils/fats that can be used in addition to raspberry seed oil, alone or in combination, as an oil/fat component in one or more compositions of the present invention. However, experiments have shown that apricot kernel oil, babassu oil, peanut oil, safflower oil, rosehip oil/wild rose oil, sunflower oil, thistle oil, avocado oil, walnut oil, rapeseed oil, almond oil, argan oil, grape seed oil, cottonseed oil, or a combination of one or more oils, preferably of at least two other oils, fats, and/or paraffins, together with an appropriate wax content, formed an effective barrier that reduced or prevented the transmission of pathogens in the genital area, thereby reducing or preventing conditions such as cystitis, interstitial cystitis, restless leg syndrome, pyelonephritis, bacterial vaginal infections (vaginosis), anal eczema, hematuria, hemorrhoids, and/or urethritis. The same was observed for dermatitis, herpes, skin diseases, and/or skin irritations. Tab. 1 Vegetable oils and their application properties Vegetable oil name density Lubricating effect adhesion Apricot kernel oil (cold pressed) 0.92 good adhesive Babusso oil (cold-pressed) 0.91 firm at the beginning, good adhesive Peanut oil (refined) 0.912 good adhesive Safflower oil (cold pressed) 0.92 good adhesive Rosehip oil / wild rose oil (cold-pressed) 0.927 good adhesive Sunflower oil (cold pressed) 0.92 good adhesive Safflower oil (cold-pressed) 0.922 good adhesive Avocado oil (cold-pressed) 0.908 good adhesive Walnut oil (cold-pressed) 0.92 good adhesive Sunflower oil (refined) 0.92 good adhesive Rapeseed oil (refined) 0.91 good adhesive Almond oil (refined) 0.915 good adhesive Argan oil (cold-pressed) 0.91 good, very moisturizing adhesive, thick texture Grape seed oil (refined) 0.925 good adhesive, thick texture Cottonseed oil (refined) 0.92 good adhesive, thick texture Hemp oil (cold-pressed) 0.927 good very oily Soybean oil (cold-pressed) 0.917 good adhesive Linseed oil (cold-pressed) 0.93 good adhesive Castor oil (cold-pressed) 0.95 difficult to distribute adhesive Sea buckthorn oil (CO2) 0.9 good adhesive Rapeseed oil (cold-pressed) 0.91 good slightly adhesive Wheat germ oil (cold pressed) 0.925 good adhesive Moringa oil (cold-pressed) 0.91 good, a bit soft adhesive Corn germ oil (refined) good adhesive Coconut oil (cold-pressed) 0.925 good slightly adhesive Shea butter (cold-pressed) 0.95 small pieces, not homogeneous non-adhesive Sesame oil (refined) 0.92 good slightly adhesive Cocoa butter (cold-pressed) 0.955 small pieces, very moisturizing slightly adhesive Olive oil (cold-pressed) 0.91 good slightly adhesive

A finger test can quickly determine which compound has better adhesive properties. To do this, hold a small amount of the compound between your index finger and thumb. The higher the adhesive strength, the more effective the compound. Table 2: Plant oils and their effects Vegetable oil name Lotus effect Comedogenicity Apricot kernel oil (cold pressed) ++ 2 Babusso oil (cold-pressed) ++ 1 Peanut oil (refined) + 2 Safflower oil (cold pressed) ++ 1 Rosehip oil / wild rose oil (cold-pressed) + 1 Sunflower oil (cold pressed) + 1 Safflower oil (cold-pressed) ++ 1 Avocado oil (cold-pressed) ++ 3 Walnut oil (cold-pressed) + 2 Sunflower oil (refined) ++ 1 Rapeseed oil (refined) ++ 1 Almond oil (refined) + 2 Argan oil (cold-pressed) +++ 0 Grape seed oil (refined) ++ 1 Cottonseed oil (refined) + 3 Hemp oil (cold-pressed) + 0 Soybean oil (cold-pressed) ++ 3 Linseed oil (cold-pressed) + 5 Castor oil (cold-pressed) + 1 Sea buckthorn oil (CO2) ++ 1 Rapeseed oil (cold-pressed) ++ 1 Wheat germ oil (cold pressed) ++ 5 Moringa oil (cold-pressed) + 1 Corn germ oil (refined) +++ 3 Coconut oil (cold-pressed) ++ 3 Shea butter (cold-pressed) 0 0 Sesame oil (refined) + 3 Cocoa butter (cold-pressed) + 4 Olive oil (cold-pressed) ++ 3

The compositions are prepared at a temperature of 55°C to 70°C, preferably in a water bath. The components of the compositions are melted and blended. The components are then cooled to room temperature with constant stirring to form the desired compositions.

The composition according to the invention is suitable for use in a method for the prophylactic and/or therapeutic treatment of cystitis, interstitial cystitis, restless leg syndrome, pyelonephritis, bacterial vaginal infections (vaginitis), anal eczema, premenstrual syndrome (PMS), hemorrhoids, and/or urethritis, as well as dermatitis, herpes, skin diseases, and/or skin irritations, comprising applying an effective amount of the composition to the relevant body areas. As a rule, a thin layer of a few millimeters, preferably between 1 mm and 5 mm, is suitable as the effective amount.

The composition for use in a method for the prophylactic and/or therapeutic treatment of cystitis, pyelonephritis, bacterial vaginal infection (vaginitis), anal eczema, premenstrual syndrome (PMS), hemorrhoids and/or urethritis is preferably applied to the inner vaginal area in women, i.e. the clitoris, the inner labia, the perineum and the anus up to the coccyx, This creates a water-insoluble layer of the composition. This layer prevents fluids from the urethra and vagina in women, as well as pathogens from the anus, from being easily transmitted. The application is preferably from the anterior to the posterior pubic area, i.e., in women, from the anterior labia to the anus.

The composition is applied to the clean, dry pubic area and left there until the next bowel movement or intimate washing. A new application of the composition is recommended afterward to protect against the transfer of bacteria and fluids between different areas of the intimate area. Application is preferably carried out using at least one finger and/or a tissue, with the composition first being applied thinly to the intimate area, i.e., the vaginal or penile area. The area around the anus is then covered with the composition, preferably using another finger or a fresh tissue. In a preferred embodiment, the composition is then distributed evenly in the next step. In women, distribution begins from the inner vaginal area and extends down to the coccyx. During distribution, any excess composition is removed, leaving only a thin, comfortable film.

Experiments have shown that the compositions are effective for 8 to 14 hours after application, preferably 12 hours. For this reason, regular reapplication of the composition is recommended to ensure consistent protection. Reapplication is preferably scheduled in the morning and evening, as well as after cleansing the pubic area. Reapplication after using the toilet (urinating without defecating) is not necessary due to the composition's excellent water-repellent properties. However, the composition should be renewed after sexual intercourse, defecation, or swimming pool visits to maintain maximum barrier protection. When used correctly, the composition is almost 100% effective. Experimental studies with the composition over a period of more than 6 years in patients with chronic complaints have shown 100% effectiveness in preventing bladder infections (cystitis), pyelonephritis, bacterial vaginal infections (vaginosis), anal eczema, PMS, hemorrhoids, and/or urethritis.

Further literature concerning known materials, methods and applications that can be used in accordance with the present invention will be apparent to those skilled in the art.

Claims (10)

A composition for the prophylactic and/or therapeutic treatment of cystitis, interstitial cystitis, restless leg syndrome, pyelonephritis, bacterial vaginal infections (vaginitis), hematuria, premenstrual syndrome (PMS), loss of libido, anal eczema, hemorrhoids and/or urethritis, dermatitis, herpes, skin diseases, and/or skin irritations, consisting of an oil or fat/wax mixture comprising: 0.5% to 5% raspberry seed oil; 16% to 30% wax; 45% to 83.5% other oil, fat, and/or paraffin components; 0% to 20% of an additive. Composition according to Claim 1 , wherein the further oil, fat and/or paraffin component is apricot kernel oil, babassu oil, peanut oil, safflower oil, rosehip oil/wild rose oil, sunflower oil, thistle oil, avocado oil, walnut oil, rapeseed oil, almond oil, argan oil, grape seed oil, cottonseed oil, hemp oil, soybean oil, linseed oil, castor oil, evening primrose oil, sea buckthorn oil, wheat germ oil, moringa oil, corn germ oil, coconut oil, shea butter, clove oil, sesame oil, St. John's wort oil, calendula oil, olive oil, cocoa butter, preferably St. John's wort oil, calendula oil, hemp oil, apricot kernel oil, soybean oil, babassu oil, peanut oil, safflower oil, linseed oil, raspberry seed oil, rosehip oil/wild rose oil, sunflower oil, thistle oil, avocado oil, olive oil, walnut oil, rapeseed oil, almond oil, argan oil, Sea buckthorn oil, grape seed oil, sesame oil, cottonseed oil, and/or wheat germ oil, preferably comprising a mixture of refined oils and cold-pressed oils, particularly preferably a proportion of cold-pressed oils of 30% to 75%. Composition according to Claim 1 or 2 , wherein at least one wax is beeswax, china wax and preen gland fat, insect wax, sugar cane wax, carnauba wax, jojoba wax, cork wax, guaruma wax (Calathea lutea), ouricuri wax (Syagrus coronata), Cuba palm wax (Copernicia hospita), esparto wax (Lygeum spartum, Stipa tenacissima), wool wax, Rice bran wax, flax wax, peat wax and rose wax, jasmine wax, myrtle wax (Myrica cerifera), wax fig wax (Ficus variegata) and/or semi-synthetic waxes from vegetable oils. Composition according to one of the Claims 1 until 3 , with a wax content of 22% to 26%. Composition according to one of the Claims 1 until 4 , wherein the composition does not comprise the addition of water and/or a water-soluble compound. Composition according to one of the Claims 1 until 5 , wherein the additive comprises natural ingredients, preferably vitamins, fruit powder, vegetable powder and/or plant powder, and/or medicines. Composition according to one of the Claims 1 until 6 , wherein the composition comprises the following components: 0.5% to 5% raspberry seed oil, preferably 1% to 3% raspberry seed oil, 16% to 30% beeswax, preferably 22% to 26%; 45% to 83.5% of a mixture of argan oil, grape seed oil, soybean oil, apricot kernel oil, rosehip oil, St. John's wort oil, calendula oil, safflower oil, avocado oil and hemp oil; 0% to 10% of a vitamin, fruit powder, essential oil, an oil extract, vegetable powder and/or plant powder; 0% to 10% of a medicament. Use of a composition according to one of the Claims 1 until 7 in a method for the prophylactic and/or therapeutic treatment of cystitis, interstitial cystitis, restless leg, pyelonephritis, bacterial vaginal infection (vaginosis), anal eczema, hemorrhoids and/or urethritis, dermatitis, herpes, skin diseases and/or skin irritations, comprising applying an effective amount of the composition to the affected area. Use according to Claim 8 , wherein the composition is preferably applied in a layer of 1 mm to 5 mm, thereby forming a water-insoluble layer, and wherein preferably the composition is applied thinly with at least one finger and/or with a cloth to a clean and dry skin region and the process is repeated if necessary. Preparation of a composition according to one of the Claims 1 until 7 , wherein the components are melted and mixed at a temperature of 55°C to 70°C, preferably in a water bath, and are then cooled with constant stirring until room temperature is reached.