DE102011077180A1 - Oral-, dental care- and -cleaning agent, useful for reducing the sensitivity of teeth against mechanical and thermal stimuli, and treating gingivitis or periodontitis, comprises a vegetable extract - Google Patents

Abstract

Oral-, dental care- and -cleaning agent comprises a vegetable extract (0.00001-10 wt.%). ACTIVITY : Antiinflammatory; Antibacterial. No biological data given. MECHANISM OF ACTION : None given.

Description

The invention relates to oral and dental care products for reducing the sensitivity of the teeth against mechanical and thermal stimuli, which at the same time thoroughly cleans the tooth surfaces and helps to reduce halitosis and periodontitis.

Dentifrices are available in various forms on the market and are primarily used to clean the tooth surface and to prevent tooth and gum disease. They usually contain a combination of polishes, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. Liquid or liquid toothpastes and mouthwashes have also become increasingly important in recent years.

In addition to the cleaning of the teeth, the consumer of the generic products also expected a care of the teeth and the oral cavity. In particular, a "clean" feeling, i. H. a smooth and shiny tooth surface as well as a fresh feeling in the mouth essential aspects for the purchase incentive of preparations for oral and dental care and cleaning. Therefore, a successful means of the generic type should thoroughly clean the teeth without damaging the tooth or the tooth surface while reducing and / or preventing halitosis.

Halitosis, also called halitosis or "foetor ex ore", can have various causes. In healthy people, however, halitosis is caused in most cases by bacteria in the mouth or throat, which metabolize body cells or food residues, as a degradation products of proteins u. a. Volatile sulfur compounds (VSC) are formed, which are held responsible for the malodour.

In particular, these sulfur compounds are: H ₂ S = hydrogen sulfide (about 30%), CH ₃ -SH = methylmercaptan (about 60%), and CH ₃ -S-CH ₃ = dimethylsulfide (about 10%).

The volatile sulfur compounds are sometimes very aggressive and can damage the gums and oral mucosa. For example, it is known that hydrogen sulfide and methylmercaptan increase the permeability of the oral mucosa and thus can promote gum disease.

Gum disease is a high risk factor for health. According to research by the World Health Organization (WHO), more than 50% of German adult citizens suffer from urgent periodontal disease.

Gum disease is often referred to as "periodontal disease". This term is incorrect because the term "-ose" describes a normal, age-related decline of an organ. Correct are the terms "periodontitis" or "inflammatory periodontal disease". In addition to caries, it is the most common disease of the oral cavity and occurs mainly in adults.

Periodontitis is a bacterial inflammatory change in the tissue surrounding the tooth, especially the jawbone. Periodontitis (involving the periodontal pockets and the bone) always develops from gingivitis, first affecting the spaces between the teeth that are the least accessible to cleaning. The bacteria in the periodontal pocket have a destructive effect on the gums, tooth substance and bones through their metabolic products, in particular the VSC you produce, and thus constantly reinforce the already existing periodontitis.

This health problem is very widespread: Studies show that around the age of 35, more teeth are lost through periodontal disease (gum disease) than through tooth decay.

There has been no lack of attempts to combat halitosis, and a variety of agents are used for this purpose in preparations for oral and dental care and cleaning. For example, triclosan, tin salts or chlorhexidine are used as antibacterial agents.

However, the use of these products may in some cases be associated with disadvantages which are partly of a taste nature and partly have aesthetic reasons, since the product and / or the teeth may be discolored by excessive use of the agents.

There is therefore still the need to combat halitosis and provide active ingredients or drug combinations for it, which are free from the disadvantages mentioned.

Some people suffer from an extreme sensitivity of the teeth, especially in the area of the tooth necks and feel an uncomfortable feeling to the point of pain when the teeth z. B. when eating cooled food or drinks or be exposed to a thermal or mechanical stimulus in contact with the toothbrush.

It is known that water-soluble salts of potassium and strontium can reduce this insensitivity to some extent. So z. In DE 24 19 384 an addition of potassium nitrate, in US 3,122,483 the addition of strontium chloride to toothpastes is recommended.

The object of the present invention was to provide preparations for oral and dental care and cleansing which desensitize the teeth and also effectively combat bad breath and are effective against gingivitis and periodontitis.

In addition, the object was to bring in further benefits in the inventive agent. In particular, the prophylaxis against caries, the treatment of surface defects on the tooth surface and thus the treatment of hypersensitivity of the teeth should be made possible by the use of the agents according to the invention.

However, it has now been found that vegetable extracts, and in particular the extracts of certain types of vegetables, have a desensitizing effect on hypersensitive teeth and act against bad breath, periodontitis and caries.

The invention therefore oral and dental care and cleaning compositions containing - based on their weight - 0.00001 to 10 wt .-% vegetable extract (s).

Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes as well as oral and dental gels. Preferably suitable are toothpastes and liquid dentifrices. For this purpose, the oral and dental care and cleaning agents z. B. in the form of toothpastes, liquid toothpastes, toothpowder, mouthwashes or possibly also as gum, z. B. as chewing gum, present. Preferably, however, they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.

As an essential ingredient, the oral and dental care and cleaning compositions of the invention contain from 0.00001 to 10% by weight vegetable extract.

Vegetables are a collective term for edible parts of plants of wild-growing or cultured, usually one- or two-year-old herbaceous plants.

Extract for the purposes of the present invention is a pressed juice, an aqueous, aqueous-alcoholic or alcoholic extract of one or more vegetables.

• – Salate, insbesondere Gartensalat (Lactuca sativa L.), Kopfsalat (Lactuca sativa L. var. capitata L.), Schnittsalat (Lactuca sativa L. var. crispa L.), Bindesalat (Lactuca sativa L. var. longifolia L.), Spargelsalat (Lactuca sativa var. angustana), Eisbergsalat, Gemeine Wegwarte (Cichorium intybus L.), Chicorée (Cichorium intybus var. foliosum), Endivie (Cichorium endivia L.), Rucola, Rauke (Diplotaxis tenuifolia oder Eruca sativa), Mangold (Beta vulgaris subsp. vulgaris), Spinat (Spinacia oleracea L.), Wasserspinat (Ipomoea aquatica FORSSK.), Gartenmelde (Atriplex hortensis L.), Brunnenkresse (Nasturtium officinale R.BR.), Portulak (Portulaca ssp. sative (HAW.) ČEL.), Gewöhnliches Tellerkraut (= Kuba-Spinat, Winterportulak, Claytonia perfoliata DONN. EX WILLD), Malabar-Spinat, Indischer Spinat (Basella alba), Neuseeländer Spinat, Neuseelandspinat (Tetragonia tetragonioides), Jambú (Acmella oleracea (L.) R. K. JANSEN), Jute-Blätter (Corchorus olitorius L.), Eiskraut (Mesembryanthemum crystallinum), Taglilien, z. B. die Gelbrote Taglilie (Hemerocallis fulva L.), Ähriger Erdbeerspinat (Chenopodium capitatum (L.) ASCH.), Guter Heinrich (Chenopodium bonus-henricus L.), Garten-Ampfer (Rumex),
• – Kohl, insbesondere Mittelmeer-Kohl (B. fruticulosa), Ruten-Kohl, oder Indischer Senf oder Serepta-Senf genannt, (B. juncea), Raps und Steckrübe (B. napus), Steckrübe, Kohlrübe, Wruke (B. napus subsp. rapifera MTZG.), Raps (B. napus subsp. napus L.), Schnittkohl (B. napus subsp. pabularia), Schwarzer Senf (B. nigra (L.) KOCH), Gemüsekohl (B. oleracea L.), Blumenkohl (B. oleracea var. botrytis L.), Romanesco (B. oleracea convar. botrytis var. botrytis L.), Brokkoli (B. oleracea var. italica Plenck), Kohlrabi (B. oleracea var. gongylodes L.), Kopfkohl (B. oleracea convar. capitata L.), Rotkohl (Brassica oleracea convar. capitata var. rubra L.), Weißkohl (Brassica oleracea convar. capitata var. alba L.), Spitzkohl, Wirsing, Savoyer Kohl (B. oleracea convar. capitata var. sabauda L.), Rosenkohl (B. oleracea var. gemmifera DC.), Grünkohl, „Braunkohl” (B. oleracea var. sabellica L.), Palmkohl (Brassica oleracea var. palmifolia DC.), Markstammkohl (B. oleracea var. medullosa Thell.), Rübsen (B. rapa L.), Ölrübsen (B. rapa subsp. oleifera), Chinakohl (B. rapa subsp. pekinensis), Pok Choi (B. rapa subsp. chinensis), Mairübe, Wasserrübe, Weiße Rübe, Teltower Rübchen, Bayerische Rübe (B. rapa subsp. rapa),

Blütengemüse, insbesondere Artischocke (Cynara scolymus), Zucchini (Curcubita pepo subsp. pepo convar. giromontiina), Blumenkohl, Broccoli, Romanesco, Lilien (Lilium L.), Dahlien (Dahlia CAV.),
Fruchtgemüse, vorzugsweise

• – Citrullus, insbesondere Wassermelone (Citrullus lanatus (THUNB.) MATSUM. & NAKAI.)
• – Gurken, insbesondere Honigmelone (Cucumis melo L.), Kiwano (Cucumis metuliferus E.MEY. EX NAUDIN), Gurke (Cucumis sativus L.)
• – Kürbisse und Zucchini (Cucurbita), insbesondere Gartenkürbis, Zucchini, Spaghettikürbis (C. pepo L.), Riesen- oder Hokkaidokürbis (C. maxima), Moschuskürbis (C. moschata), Feigenblatt-Kürbis (C. ficifolia),

Bittermelone (Momordica L., 45 Arten),
Flaschenkürbisse (Lagenaria siceraria (MOLINA) STANDL.),
Schwammkürbis (Luffa MILL.),
Sechium,
Chayote = Christofine, (Sechium edule (JACQ.) SW.),
Tomate (Solanum lycopersicum L.),
Amaranth (Amaranthus L.),
Aubergine (Solanum melongena),
Avocado (Persea americana MILL.),
Okra (Abelmoschus esculentus (L.) MOENCH.),
Brotfrucht (Artocarpus altitis (PARKINS. EX DU ROI) FOSB. CORR. ST.JOHN),
Wurzelgemüse, vorzugsweise
Knollengemüse, insbesondere Gelbe Rübe, Mohrrübe (Daucus carota L. ssp. sativus), Steckrübe, Kohlrübe (Brassica napus subsp. rapifera), Mairübe (Brassica rapa subsp. rapa var. majalis), Teltower Rübchen (Brassica rapa subsp. rapa var. pygmaea), Meerrettich (Armoracia rusticana GAERTN.MEY. & SCHERB.), Radieschen (Raphanus sativus L. subsp. sativus), Schwarzer Winter-Rettich (Raphanus sativus subsp. niger var. niger), Wasabi (Wasabia japonica MATSUM.) (Kreuzblütler), Kartoffel (Solanum tuberosum L.), Garten-Schwarzwurzel (Scorzonera hispanica L.), Pastinake, Wurzelpetersilie, Sellerie (Apium graveolens), Kerbelrübe oder Knolliger Kälberkropf (Chaerophyllum bulbosum L.), Lotoswurzel,
Zwiebelgemüse, insbesondere Allium (Lauchgewächse) wie Zwiebel (A. cepa L.), Winterzwiebel, Frühlingszwiebel, (A. fistulosum L.), Knoblauch (A. sativum L.), Schalotte (A. ascalonicum STRAND.), Porree, Lauch (A. porrum L.), Perlzwiebel (Allium porrum var. sectivum), Bärlauch (Allium ursinum),
Hülsenfrüchte, vorzugsweise

• – Phaseolus, wie Limabohne (Phaseolus lunatus L.), Mondbohne, Teparybohne (Phaseolus acutifolius A.GRAY), Feuerbohne (Phaseolus coccineus L.), Schminkbohne, Gartenbohne, Buschbohne, Stangenbohne, (Phaseolus vulgaris L.), insbesondere die Sorten Kidney-Bohne, Nierenbohne, Perlbohne, Wachtelbohne, Pintobohne, Schwarze Bohne, Weiße Bohne,
• – Sojabohne (Glycine max (L.) Merill)
• – Erbse (Pisum), insbesondere Schalerbse (Pisum sativum L. convar. sativum), auch Pahl-, Pal- oder Kneifelerbsen, Markerbse (Pisum sativum L. convar. medullare Alef. emend. C.O. Lehm), Zuckererbse (Pisum sativum L. convar. axiphium Alef emend. C.O. Lehm), auch Kaiserschoten, Kiefelerbsen oder Kefen, (Zuckerschote), Riesenerbse (Pisum granda sneida L. convar. sneidulo p. shneiderium)
• – Schneckenklee (Medicago L.), Gewöhnliche Luzerne, Luzerne (M. sativa L.),
• – Kichererbse (Cicer arietinum L.)
• – Linsen, (Lens), (Lens culinaris Medik.)
• – Lupinen (Lupinus L.)
• – Wicken (Vicia L.), Ackerbohne, Dicke Bohne, Saubohne (Vicia faba L.),
• – Platterbsen (Lathyrus L.), insbesondere Saat-Platterbse (Lathyrus sativus L.), Knollen-Platterbse (Lathyrus tuberosus L.)
• – Vigna, insbesondere Mattenbohne, (Vigna aconitifolia (Jacq.) Maréchal), Adzukibohne, (Vigna angularis (Willd.) Ohwi & H. Ohashi), Urdbohne, (Vigna mungo (L.) Hepper), Mungbohne, (Vigna radiata (L.) R. Wilczek), „Sojasprossen”, Bambara-Erdnuss, (Vigna subterrane (L.) Verdc.), Reisbohne, (Vigna umbellata (Thunb.) Ohwi & H. Ohashi), Vigna vexillata (L.), Vigna unguiculata (L.) Walp., Spargelbohne, Augenbohne, Catjang-Bohne
• – Straucherbse, (Cajanus cajan (L.) Millsp.),
• – Macrotyloma, Erdbohne, (Macrotyloma geocarpum (Harms) Maréchal & Baudet), Pferdebohne, (Macrotyloma uniflorum (Lam.) Verdc.)
• – Goabohne, (Psophocarpus tetragonolobus (L.) DC.),
• – Knollenbohne, (Sphenostylis stenocarpa (Hochst. ex A. Rich.) Harms)
• – Faselbohne, Helmbohne, Lablab-Bohne, (Lablab purpureus (L.) Sweet)
• – Guarbohne (Cyamopsis tetragonolobus (L.) Taub.)
• – Canavalia, insbesondere Jackbohne, (Canavalia ensiformis (L.) DC.), Schwertbohne, (Canavalia gladiata (Jacq.) DC.),

sowie Batis (Batis L.), Daikon,

• • Eibisch (Althaea officinalis L.), Japanischer Rhabarber (Fallopia japonica (Houtt.) Ronse Decr.), Koriander (Coriandrum sativum L.), Süßkartoffel (Ipomoes batatas L.), Quinoa (Chenopodium quinoa Willd.), Schwedische Rübe (Brassica napus), Wassermimose (Neptunia oleracea Lour.), Maniok, Mandioka, Kassava, Kassave oder in Lateinamerika Yuca (Manihot esculenta Crantz).

According to preferred vegetables are
Leafy vegetables, preferably

• Salads, in particular garden salad (Lactuca sativa L.), lettuce (Lactuca sativa L. var. Capitata L.), cut salad (Lactuca sativa L. var. Crispa L.), binding salad (Lactuca sativa L. var. Longifolia L.) , Asparagus salad (Lactuca sativa var. Angustana), iceberg lettuce, common chicory (Cichorium intybus L.), chicory (Cichorium intybus var. Foliosum), endive (Cichorium endivia L.), arugula, rocket (Diplotaxis tenuifolia or Eruca sativa), Swiss chard (Beta vulgaris subsp. Vulgaris), spinach (Spinacia oleracea L.), water spinach (Ipomoea aquatica FORSSK.), Garden bloom (Atriplex hortensis L.), watercress (Nasturtium officinale R.BR.), purslane (Portulaca ssp. Sative (HAW .) ČEL.), Common plate cabbage (= Cuban spinach, Winter portulac, Claytonia perfoliata DONN, EX WILLD), Malabar spinach, Indian spinach (Basella alba), New Zealand spinach, New Zealand spinach (Tetragonia tetragonioides), Jambú (Acmella oleracea (L. .) RK JANSEN), jute Leaves (Corchorus olitorius L.), weevil (Mesembryanthemum crystallinum), daylilies, e.g. B. Gelbrote Daylily (Hemerocallis fulva L.), Strawberry Spinat (Chenopodium capitatum (L.) ASCH.), Heinrich (Chenopodium bonus henricus L.), Garden Dock (Rumex),
• - Cabbage, in particular Mediterranean cabbage (B. fruticulosa), rodent cabbage, or Indian mustard or Serepta mustard, (B. juncea), oilseed rape and rutabaga (B. napus), rutabaga, turnip, worm (B. napus subsp. rapifera MTZG.), oilseed rape (B. napus subsp. napus L.), cutting cabbage (B. napus subsp. pabularia), black mustard (B. nigra (L.) KOCH), cabbage (B. oleracea L.) , Cauliflower (B. oleracea var. Botrytis L.), Romanesco (B. oleracea convar botrytis var. Botrytis L.), broccoli (B. oleracea var. Italica Plenck), kohlrabi (B. oleracea var. Gongylodes L.) , Head cabbage (B. oleracea convar capitata L.), red cabbage (Brassica oleracea convar capitata var., Rubra L.), cabbage (Brassica oleracea convar capitata var alba L.), cabbage, savoy cabbage, Savoy cabbage (B. oleracea convar. capitata var. sabauda L.), Brussels sprouts (B. oleracea var. gemmifera DC.), kale, "brown cabbage" (B. oleracea var. sabellica L.), palm cabbage (Brassica oleracea var. palmifolia DC.), Marrow trunk cabbage (B. oleracea var. Medullosa Thel l.), turnip rape (B. Rapa L.), oil turnips (B. rapa subsp. oleifera), Chinese cabbage (B. rapa subsp. pekinensis), Pok Choi (B. rapa subsp. chinensis), whitefish, turnip, turnip, Teltower turnip, Bavarian turnip (B. rapa subsp. rapa),

Flowering vegetables, in particular artichoke (Cynara scolymus), zucchini (Curcubita pepo subsp. Pepo convar giromontiina), cauliflower, broccoli, Romanesco, lilies (Lilium L.), dahlias (Dahlia CAV.),
Fruit vegetables, preferably

• - Citrullus, in particular watermelon (Citrullus lanatus (THUNB.) MATSUM. & NAKAI.)
• - cucumbers, in particular honeydew melon (Cucumis melo L.), kiwano (Cucumis metuliferus E.MEY, EX NAUDIN), cucumber (Cucumis sativus L.)
• - pumpkins and zucchini (Cucurbita), in particular garden squash, zucchini, spaghetti squash (C. pepo L.), giant or hokkaido squash (C. maxima), butternut squash (C. moschata), fig leaf squash (C. ficifolia),

Bitter melon (Momordica L., 45 species),
Gourds (Lagenaria siceraria (MOLINA) STANDL.),
Sponge gourd (Luffa Mill.),
Sechium,
Chayote = Christofine, (Sechium edule (JACQ.) SW.),
Tomato (Solanum lycopersicum L.),
Amaranth (Amaranthus L.),
Eggplant (Solanum melongena),
Avocado (Persea americana MILL.),
Okra (Abelmoschus esculentus (L.) MOENCH.),
Breadfruit (Artocarpus altitis (PARKINS EX DU ROI) FOSB CORR ST.JOHN),
Root vegetables, preferably
Tuber crops, in particular yellow turnip, carrot (Daucus carota L. ssp. Sativus), rutabaga, turnip (Brassica napus subsp. Rapifera), mustard (Brassica rapa subsp. Rapa var. Majalis), Teltower turnip (Brassica rapa subsp. Rapa var. pygmaea), horseradish (Armoracia rusticana GAERTN.MEY. & SCHERB.), radish (Raphanus sativus L. subsp. sativus), black winter radish (Raphanus sativus subsp. niger var. niger), wasabi (wasabia japonica MATSUM.) ( Cruciferous vegetables), potato (Solanum tuberosum L.), garden salsify (Scorzonera hispanica L.), parsnips, root parsley, celery (Apium graveolens), chervil, or nodular calf's cabbage (Chaerophyllum bulbosum L.), lotus root,
Onion vegetables, in particular allium (leek) such as onion (A. cepa L.), winter onion, spring onion, (A. fistulosum L.), garlic (A. sativum L.), shallot (A. ascalonicum BEACH), leek, leek (A. porrum L.), pearl onion (Allium porrum var. Sectivum), wild garlic (Allium ursinum),
Legumes, preferably

• - Phaseolus, such as lima bean (Phaseolus lunatus L.), moon bean, tepary bean (Phaseolus acutifolius A.GRAY), common bean (Phaseolus coccineus L.), make-up bean, common bean, common bean, common bean, (Phaseolus vulgaris L.), in particular Kidney varieties Bean, Kidney Bean, Pea Bean, Quail Bean, Pinto Bean, Black Bean, White Bean,
• - Soybean (Glycine max (L.) Merill)
• - pea (Pisum), in particular burbot (Pisum sativum L. convar sativum), also Pahl, Pal or Kneifel peas, marrow pea (Pisum sativum L. convar, medullar Alef emend, CO clay), sugar pea (Pisum sativum L. convar, axiphium Alef emend, CO loam), also Kaiserschoten, Kiefeler peas or Kefen, (Zuckerschote), Riesenerbse (Pisum granda sneida L. convar., sneidulo P. shneiderium)
• - snail clover (Medicago L.), common alfalfa, alfalfa (M. sativa L.),
• - Chickpea (Cicer arietinum L.)
• - Lentils, (Lens), (Lens culinaris Medik.)
• - Lupins (Lupinus L.)
• - vetches (Vicia L.), broad bean, broad bean, broad bean (Vicia faba L.),
• - flat peas (Lathyrus L.), in particular seed flat pea (Lathyrus sativus L.), tuber flat pea (Lathyrus tuberosus L.)
• - Vigna, in particular mat bean, (Vigna aconitifolia (Jacq.) Maréchal), adzuki bean, (Vigna angularis (Willd.) Ohwi & H. Ohashi), common bean, (Vigna mungo (L.) Hepper), mung bean, (Vigna radiata (Vigna radiata) L.) R. Wilczek), "bean sprouts", Bambara peanut, (Vigna subterrane (L.) Verdc.), Rice bean, (Vigna umbellata (Thunb.) Ohwi & H. Ohashi), Vigna vexillata (L.), Vigna unguiculata (L.) Walp., Asparagus bean, cowpea, catjang bean
• - pigeon pea, (Cajanus cajan (L.) Millsp.),
• - Macrotyloma, bean, (Macrotyloma geocarpum (Harms) Maréchal & Baudet), horse bean, (Macrotyloma uniflorum (Lam.) Verdc.)
• - Goabohne, (Psophocarpus tetragonolobus (L.) DC.),
• - tuber bean, (Sphenostylis stenocarpa (supreme ex A. rich.) Harms)
• - Bean, Helmet Bean, Lablab Bean, (Lablab purpureus (L.) Sweet)
• - Guar bean (Cyamopsis tetragonolobus (L.) Taub.)
• - Canavalia, in particular jack bean, (Canavalia ensiformis (L.) DC.), Sword bean, (Canavalia gladiata (Jacq.) DC.),

and Batis (Batis L.), Daikon,

• • Marshmallow (Althaea officinalis L.), Japanese Rhubarb (Fallopia japonica (Houtt.) Ronse Decr.), Coriander (Coriandrum sativum L.), Sweet Potato (Ipomoes batatas L.), Quinoa (Chenopodium quinoa Willd.), Swedish Turnip ( Brassica napus), water mimosa (Neptunia oleracea Lour.), Cassava, mandioca, cassava, cassava or in Latin America Yuca (Manihot esculenta Crantz).

An extract in the sense of the present application is a substance or substance mixture which has been obtained by pressing (pressed juice) or extraction and partial or complete evaporation of the juice or the extraction solution. A distinction is made according to the nature dry extracts d. H. Extracted to dryness extracts, fluid extracts d. H. extracts prepared with solvents such that at most 2 parts of fluid extract are recovered from one part of the drug, viscous extracts or thickness extracts, d. H. Extracts in which part of the solvent is evaporated.

Of course, several vegetable extracts can be used, as it is possible to mix several vegetables together and submit to an extraction. The blending with compressed juices is possible according to the invention. The term "vegetable extract" used below is therefore not necessarily to be understood as a singular, but always includes several extracts and extracts mixtures.

Preferably, the vegetable extract is used within narrower ranges. Here, oral and dental care and cleaning agents according to the invention are preferred, which are 0.00005 to 2.5 wt .-%, preferably 0.0001 to 2.0 wt .-%, particularly preferably 0.0005 to 1.0 wt. -%, more preferably 0.001 to 0.75 wt .-% and in particular 0.01 to 0.5 wt .-% vegetable extract.

Particularly preferred mouth and dental care and cleaning compositions according to the invention contain at least one extract from the group artichoke extract, broccoli extract, asparagus extract, cucumber extract, beetroot extract, avocado extract, eggplant extract, spinach extract, tomato extract, zucchinia extract, celery extract, mangold extract, carrot extract.

In addition to the vegetable extract or the vegetable extracts or in its or their place, the inventive compositions may contain vegetable juice or vegetable juices. Again, the amounts are preferably within narrower ranges. Agents preferred according to the invention are characterized in that they contain, based on their weight, from 0.00005 to 2.5% by weight, preferably from 0.0001 to 2.0% by weight, particularly preferably from 0.0005 to 1.0% by weight .-%, more preferably 0.001 to 0.75 wt .-% and in particular 0.01 to 0.5 wt .-% of at least one vegetable juice.

Vegetable juice is the name given to the juice produced from vegetables after comminution, pressing or centrifuging and pasteurisation or sterilization, undiluted and preserved.

According to the German Food Book, vegetable juice is the undiluted, fermentable, fermented and fermented or lactic fermented, liquid vegetable product intended for direct consumption. Vegetable juice can then also be made from concentrate of vegetable juice or -mark.

Vegetable juice is made from fresh or cold preserved vegetables or parts thereof. The vegetables must be healthy, clean or washed and, if necessary, blanched. In this case, no more water may remain in the vegetables than is technically unavoidable.

The vegetables are minced, squeezed, centrifuged and filtered. Subsequently, it is preserved by pasteurization and sterilization or a combination process. Technically required additives such as bentonite (as fining agent), amylases and pectinases (for the opening of the cell walls in the pressing process), gelatine (to adjust the viscosity), calcium carbonate, citric acid and vitamin C (for stabilization and preservation) can be used and are not subject to declaration.

Processed primarily tomatoes, but z. As well as cucumbers, carrots, radish, beets, sauerkraut, celery and spinach. In contrast to fruit juice, cellulolytic and hemicellulolytic enzymes may also be used in vegetable juice production. Acidification by lactic acid fermentation or citric acid additives is common.

Vegetable juices to be used particularly preferably are - individually or mixed with one another - rhubarb juice and / or chard juice. In summary, agents according to the invention which contain at least one vegetable juice from the group rhubarb juice, kohlrabi juice, celeriac juice, carrot juice, beetroot juice, onion juice, leek juice, garlic juice, white cabbage juice, asparagus juice, spinach juice, chard juice, tomato juice, cucumber juice, pumpkin juice, pea juice, bean juice, Artichoke juice, cauliflower juice, kale juice, red cabbage juice, broccoli juice, Brussels sprouts juice included.

For organic reasons and taking into account the sustainability aspect, organically grown vegetables are to be preferred. Therefore, agents according to the invention which contain exclusively vegetable extracts and / or vegetable juices from controlled biological cultivation are particularly preferred.

The desensitizing effect of the vegetable extract can be further increased by the addition of known desensitizing substances, whereby a synergistic effect is observed. Preferred oral and dental care and cleaning agents according to the invention therefore contain the insensitivity of the teeth-enhancing substances, preferably potassium salts.

Preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain from 0.5 to 9.5% by weight, preferably from 1 to 9% by weight, more preferably from 2 to 8% by weight, even more preferably 3 to 7 wt .-% and in particular 4 to 6 wt .-% potassium salt (s) included.

Although there are no restrictions on the choice of potassium salts, preferred potassium salts are readily water soluble. Particularly preferred mouth and dental care and cleaning compositions according to the invention are characterized in that they contain exclusively potassium salt (s), which (s) at 20 ° C, a solubility in distilled water above 200 g / l, preferably above 250 g / and in particular above 300 g / l.

Suitable water-soluble salts of potassium are, for. Potassium chloride, potassium sulfate, potassium bicarbonate, potassium citrate, potassium acetate, potassium lactate and potassium nitrate. Potassium nitrate is preferred.

It has been found that the desensitizing effect of potassium salts on hypersensitive teeth is increased by the use of vegetable extract (s) and vice versa. The increase is observed especially within certain weight ratios of the components to one another. In preferred oral and dental care and cleaning compositions according to the invention, the weight ratio between vegetable extract and the total amount of potassium salt (s) is 1: 1000 to 1: 1, preferably 0.5: 100 to 75: 100, more preferably 1: 100 to 50: 100, more preferably 1.5: 100 to 10: 100 and especially 2: 100 to 3: 100.

In addition to the potassium salts, the compositions of the invention may also contain strontium salts. Suitable water-soluble salts of strontium are strontium chloride, strontium nitrate, strontium citrate, strontium acetate and strontium lactate.

The combination according to the invention against sensitive teeth is particularly effective if the water content of the compositions according to the invention is specifically tailored to them. Especially in water-poorer formulations, the effect of desensitization is particularly pronounced. Here, preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain less than 60% by weight, preferably less than 55% by weight, more preferably less than 50% by weight and in particular less than 45% by weight. % Water.

Another ingredient that can further reduce the sensitivity of teeth in combination with the potassium salt and the vegetable extract, Eugneol or clove bud oil has been proven. Clove bud oil usually contains 70-90% by weight of eugenol besides 10-15% by weight of eugenol acetate (odor component) as well as smaller amounts of alcohols, methyl esters, ketones and sesquiterpenes.

Preferred oral and dental care and cleaning compositions according to the invention additionally contain 0.01 to 1 wt .-%, preferably 0.025 to 0.5 wt .-% and in particular 0.05 to 0.2 wt .-% eugenol and / or clove bud oil.

The agents according to the invention are in themselves already effective against bad breath (halitosis) as well as periodontitis and / or gingivitis. To increase these effects, they may contain other anti-inflammatory substances.

The compositions according to the invention, in particular the toothpastes, can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included. Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.

As non-cationic, bactericidal component z. As phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. B. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2 ' hydroxydiphenyl ether (triclosan). They are preferably used in amounts of 0.01-1% by weight in the dentifrices according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3 wt .-%.

• – Panthenol oder einem Salz der Pantothensäure und
• – Retinol oder einem Derivat davon.

Preferred oral and dental care and cleaning compositions of the present invention contain a combination of anti-inflammatory properties to enhance anti-inflammatory properties

• - Panthenol or a salt of pantothenic acid and
• Retinol or a derivative thereof.

D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid. The pantothenic acid (R - (+) - N- (2,4-dihydroxy-3,3-dimethylbutyryl-β-alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3). These substances are known to promote wound healing and have a beneficial effect on the skin and have therefore been occasionally described in toothpastes The dentifrices of the invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid ,

Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having a similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters is preferably used, a retinol ester, in particular a fatty acid ester of a fatty acid having 12-22 C atoms Retinol palmitate is particularly preferably used When using a retinol ester, for example retinol palmitate with an activity of 1.7 × 10 ⁶ IU per g, an amount of 0.001 to 0.1% by weight is preferred When using other retinol derivatives, it is recommended to use at a concentration of 10 ³ to 10 ⁶ IU (International Units) per 100 g.

Preferred dentifrices according to the present invention preferably contain, in addition to polishing agents, fluorine compounds, humectants and binders
0.01-1 wt .-% of a halogenated diphenyl ether
0.05-5 wt.% Panthenol or a salt of pantothenic acid and
0.01-0.1% by weight of a retinol ester, preferably retinol palmitate.

The oral and dental care and cleaning compositions according to the invention contain further ingredients.

Preference is given to the use of so-called humectants, which prevent dehydration in toothpastes. In so-called liquid tooth creams with flowable rheology, these serve as a matrix and are used in higher amounts.

Here, oral and dental care and cleaning compositions according to the invention are preferred, which - based on their weight - 10 to 60 wt .-%, preferably 12.5 to 50 wt .-%, particularly preferably 15 to 45 wt .-% and in particular Contain 20 to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1,2-Propylenglycol .-%.

beschreiben und kommt in Form farbloser, mäßig hygroskopischer, optisch aktiver Nadeln, welche sich leicht in Wasser lösen, in den Handel.Sorbitol (also called glucitol) is a sugar alcohol of glucose, which is a hexitol. Sorbitol can be prepared by hydrogenation of glucose, it breaks down intramolecularly relatively easily one or two molecules of water and forms cyclic ethers. Sorbitol can be expressed by the formula

describe and comes in the form of colorless, moderately hygroscopic, optically active needles, which dissolve easily in water, in the trade.

Glycerin (1,2,3-Propanediol, 1,2,3-Trihydroxypropane, Glycerol, Oil Sweet, INCI name: Glycerin, E 422) is a colorless, clear, heavy-bodied, odorless, sweet-tasting, hygroscopic liquid that combines with water and alcohol is miscible in any ratio.

beschreiben. Die Herstellung von Glycerin erfolgte ursprünglich als Nebenprodukt der Fettverseifung. Die heutigen technischen Verfahren gehen von Propen aus, dass über die Zwischenstufen Allylchlorid und Epichlorhydrin zu Glycerin verarbeitet wird. Ein weiteres technisches Verfahren ist die Hydroxylierung von Allylalkohol mit Wasserstoffperoxid am WO₃-Kontakt über die Stufe des Glycids.Glycerol can be defined by the formula

describe. The production of glycerin was originally as a by-product of fat saponification. The current technical processes are based on propene that is processed via the intermediates allyl chloride and epichlorohydrin to glycerol. Another technical process is the hydroxylation of allyl alcohol with hydrogen peroxide at the WO ₃ contact via the step of the glycide.

1,2-Propylene glycol (1,2-propanediol) is a colorless and highly hygroscopic liquid that is miscible in any ratio with water and alcohols (such as methanol, ethanol, propanols, butanols). Technical 1,2-propanediol is a racemate of (-) - (R) - and (+) - (S) -1,2-propylene glycol. The preparation is carried out by direct hydrolysis of propylene oxide. Because 1,2-P. further reacted with propylene oxide, thereby forming a mixture of 1,2- and tripropylene glycol, which must be separated by distillation. 1,2-propylene glycol can also be made from renewable resources via three different routes: a) catalytic hydrogenation of sugars; b) fermentation of sugars to lactic acid and then hydrogenation of the lactic acid ester; c) direct fermentation of sugars.

For certain applications, it may be advantageous to use only one of the three ingredients mentioned above. In most cases, sorbitol is preferred. However, in other applications, mixtures of two of the three or all three may be preferred. Here, a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1) :( 0.1-0.5) has proved to be particularly advantageous.

In addition to sorbitol or glycerol or 1,2-propylene glycol are suitable as further polyhydric alcohols are those having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.

Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1,2-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH ( OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used.

Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.

As preferred further polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.

Particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol are particularly preferred.

In addition, the use of glycerol is also preferred, so that agents which contain no other polyhydric alcohols other than glycerol are particularly preferred.

The use of abrasive articles (abrasives) is also preferred. Cleaning bodies are amorphous, predominantly inorganic, largely water-insoluble, smallest-particle powders which have no sharp edges. In dental and oral care products, they promote the cleaning of the teeth and at the same time polish the tooth surface (polishing agent).

As a polishing agent are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions. Preferably suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.

Calcium-containing polishing components such. As chalk, calcium pyrophosphate, dicalcium phosphate dihydrate but in amounts up to 5 wt .-% - based on the total composition - may be included.

The total content of polishing agents is preferably in the range of 5-50% by weight of the dentifrice.

Toothpastes and liquid dentifrices containing silicic acids as a polishing agent are particularly preferred. Suitable silicas are, for. As gel silicas, hydrogel silicic acids and precipitated silicas. Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying takes place under mild conditions to water contents of 15 to 35 wt .-%, the so-called hydrogel silicas are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.

A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15-110 m ² / g, a particle size of 0.5-20 microns, wherein at least 80 wt .-% of the primary particles should be less than 5 microns, and a viscosity in 30% glycerol-water (1: 1) dispersion of 30-60 Pa.s (20 ° C) in an amount of 10-20% by weight of the dentifrice. Particularly suitable precipitated silicas of this type have rounded corners and edges and are commercially available under the trade name ^® Sident 12 DS (DEGUSSA).

Other precipitated silicas of this type are ident ^® 8 (DEGUSSA) and Sorbosil® ^® AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 microns at a specific surface area of 40-75 m ² / g (according to BET) and are particularly suitable for liquid toothpastes. These should have a viscosity (25 ° C, shear rate D = 10 s ^-1 ) of 10-100 Pa · s.

On the other hand, toothpastes which have a significantly higher viscosity of more than 100 Pa.s (25 ° C., D = 10 s ^-1 ) require a sufficiently high proportion of silicas having a particle size of less than 5 μm, preferably at least 3% by weight. -% of a silica with a particle size of 1-3 microns. Such toothpastes are therefore preferred in addition to the mentioned precipitated silicas even finer, so-called thickening silicas having a BET surface area of 150-250 m ² / g, z. As the commercial products Sipernat 22 LS or Sipernat ^® 320 DS.

As a further polish component can also z. For example, alumina in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-% may be included. Such a suitable alumina is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).

As a polishing agent are all further known for toothpastes friction body such. B. sodium aluminum silicates such. As zeolite A, organic polymers such. As polymethacrylate or mixtures of these and the aforementioned friction body.

In summary, oral and dental care and cleaning compositions according to the invention are preferred which additionally comprise cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ .2H ₂ O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular Polymethacrylates or mixtures of these friction bodies, preferably in amounts of from 1 to 30 wt .-%, preferably from 2.5 to 25 wt .-% and in particular from 5 to 22 wt .-%, each based on the total agent.

The stated amounts relate to the total amount of friction bodies, wherein individual friction bodies are preferably used in narrower ranges. Agents preferred according to the invention contain, for example, 5 to 20% by weight, preferably 8 to 21% by weight, more preferably 9 to 20% by weight and in particular 11 to 19% by weight of silica (s). Further preferred agents according to the invention are characterized in that they contain 0.25 to 2 wt .-%, preferably 0.5 to 1.5 wt .-% and in particular 0.75 to 1.25 wt .-% alumina.

Oral and dental care and cleaning agents, especially toothpastes, z. B. also contain substances that are effective against plaque and / or tartar.

Plaque is a rough, sticky deposit on the teeth that consists of saliva, bacteria and food remnants. If mineral salts (eg calcium, phosphate) are released from the saliva in the dental plaque, hard, white or yellowish deposits on the tooth, called tartar, form. In the porous calculus, in turn, easily deposit plaque that attacks the gums.

The bacteria on the tooth surface reduce carbohydrates, especially sugars, from food to acid. This acid dissolves the tooth substance and it comes to tooth decay (tooth rot). In particular, the minerals calcium and phosphate are extracted from the enamel. After the enamel coat also inner layers of the tooth are attacked. Bacteria can invade the dental pulp and cause inflammation there. Mostly it comes then to stinging toothache.

As already mentioned, plaque contains bacteria, so that antimicrobials are suitable for controlling plaque. These also have an effect as a preservative.

Sorbic acid (E 200), potassium sorbate (E 202), calcium sorbate (E 203), benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212 ), Calcium benzoate (E 213), ethyl 4-hydroxybenzoate (E 214), ethyl 4-hydroxybenzoate, sodium salt (E 215), propyl 4-hydroxybenzoate (E 216), propyl 4-hydroxybenzoate, sodium salt (E 217 ), Methyl 4-hydroxybenzoate (E 218), methyl 4-hydroxybenzoate, sodium salt (E 219), sulfur dioxide (sulfurous acid), (E 220), sodium sulfite (E 221), sodium hydrogen sulfite (E 222), sodium disulfite (E. 223), potassium bisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227), potassium bisulfite (E 228), biphenyl (E 230), orthophenylphenol (2-biphenylol), (E 231), sodium orthophenylphenolate (E 232) , Nisin (E 234), natamycin (E 235), formic acid (E 236), sodium formate (E 237), calcium formate (E 238), hexamethylenetetramine (E 239), dimethyldic arbonate (E 242), potassium nitrite (E 249), sodium nitrite (E. 250), sodium nitrate (E 251), acetic acid (E 260), potassium acetate (E 261), sodium acetate (E 262), calcium acetate (E 263), lactic acid (E 270), propionic acid (E 280), sodium propionate (E 281) , Calcium propionate (E 282), potassium propionate (E 283), boric acid (E 284), sodium tetraborate (E 285), malic acid (malic acid), (E 296), fumaric acid (E 297), lysozyme (E 1105).

Preferred substances are selected from alkypyridinium salts, in particular cetylpyridinium chloride, p-hydroxybenzoic acid methyl, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylic acid ester, biguanides, for example. Chlorhexidine (1,1'-hexamethylenebis [5- (4-chlorophenyl) -biguanide), thymol, etc.

Oral and dental care and cleaning compositions which are preferred according to the invention are additionally characterized in that they additionally contain antiplaque active substances, preferably alkylpyridinium salts, in particular cetylpyridinium chloride, methyl, ethyl or propyl p-hydroxybenzoate, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, hexetidines, phenyl- Salicylic acid esters, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.05 to 5 wt .-%, preferably from 0.10 to 2.5 wt .-% and in particular from 0.30 to 1.5 wt .-%, respectively on the entire remedy, included.

The stated amounts are based on the total amount of antiplaque active ingredients, wherein individual active ingredients are preferably used in narrower ranges. Agents preferred according to the invention contain, for example, 0.1 to 2% by weight, preferably 0.2 to 1.75% by weight, more preferably 0.3 to 1.5% by weight and in particular 0.4 to 1.0 Wt .-% sodium benzoate. Further preferred agents according to the invention are characterized in that they contain 0.005 to 0.1 wt .-%, preferably 0.01 to 0.075 wt .-% and in particular 0.02 to 0.05 wt .-% chlorhexidine. Chlorhexidine is preferably used together with alkylpolyglycosides (APG), wherein in preferred agents according to the invention as alkyl glycosides those having 8-18 carbon atoms in the alkyl group and a mean degree of oligomerization of the glycoside of 1-3 in an amount of 0.025 to 2.5 wt. -% are included.

Anti-calculus substances may be, for example, chelating agents such. As ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na ₄ P ₂ O ₇ , K ₄ P ₂ O ₇ , Na ₂ K ₂ P ₂ O ₇ , Na ₂ H ₂ P ₂ O ₇ and K ₂ H ₂ P ₂ O ₇ or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.

In accordance with the invention preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.

As a consistency regulator (or binder) serve z. As natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. As carboxymethyl cellulose (Na salt), hydroxyethyl cellulose, methyl hydroxypropyl cellulose, guar, Akaziengum, agar-agar, xanthan gum, succinoglycan gum, locust bean flour, pectins, water-soluble carboxyvinyl polymers (eg. Carbopol ^® types), polyvinyl alcohol, polyvinyl pyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1500-1000000.

Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.

Surface-active substances are also present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam in brushing teeth and for stabilizing the polishing body dispersion in the carrier in an amount of 0.1-5% by weight.

Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque. Other suitable surfactants are alkali metal salts, preferably sodium salts of alkylpolyglycol ether sulfate with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ₁₂ - C ₁₈ ) sulfonate, sulfosuccinic monoalkyl (C ₁₂ -C ₁₈ ) esters, sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C ₁₂ -C ₁₆ ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group. Also zwitterionic, ampholytic and nonionic surfactants are suitable, for. B. Oxethylates of fatty acid mono- and diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides.

The agents according to the invention, in particular the toothpastes, may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.

In addition, oral and dental care and cleaning agents may more preferably contain anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, tin (II) fluoride are preferred. Preferably, an amount of 0.01-0.2 wt .-% fluorine should be included in the form of the compounds mentioned.

Oral and dental care and cleaning preparations according to the invention, which additionally contain anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, tin fluoride and sodium fluorosilicate, preferably in amounts of from 0.01 to 5% by weight, preferably from 0.1 to 2.5 wt .-% and in particular from 0.2 to 1.1 wt .-%, each based on the total agent, are preferred according to the invention.

The dentifrice according to the invention can, for. B. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.

As aroma oils, all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.

Suitable flavors are z. As peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamaldehyde, anethole, vanillin, thymol and mixtures of these components.

Suitable sweeteners are z. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose, and maltose and dextrose.

• – Oberflächenaktive Stoffe, bevorzugt anionische, zwitterionische, amphotere, nicht-ionische Tenside oder eine Kombination mehrerer verschiedener Tenside
• – Lösungsmittel und Lösungsvermittler, z. B. niedere einwertige oder mehrwertige Alkohole oder Ether, z. B. Ethanol, 1,2-Propylenglycol, Diethylenglycol oder Butyldi-glycol
• – Pigmente, wie z. B. Titandioxid
• – Farbstoffe
• – Puffersubstanzen, z. B. primäre, sekundäre oder tertiäre Alkaliphosphate oder Citronensäure-/Na-Citrat
• – weitere wundheilende oder entzündungshemmende Stoffe, z. B. Allantoin, Harnstoff, Azulen, Kamillewirkstoffe, Acetylsalicylsäurederivate oder Rhodanid
• – weitere Vitamine wie z. B. Ascorbinsäure, Biotin, Tocopherol oder Rutin
• – Mineralsalze wie z. B. Mangan-, Zink- oder Magnesiumsalze.

Further customary auxiliaries and additives for toothpastes are

• - Surface-active substances, preferably anionic, zwitterionic, amphoteric, nonionic surfactants or a combination of several different surfactants
• - Solvents and solubilizers, eg. As lower monohydric or polyhydric alcohols or ethers, for. For example, ethanol, 1,2-propylene glycol, diethylene glycol or butyl di-glycol
• - pigments, such as. For example, titanium dioxide
• - Dyes
• - Buffer substances, for. As primary, secondary or tertiary alkali metal phosphates or citric acid / Na citrate
• - other wound-healing or anti-inflammatory substances, eg. Allantoin, urea, azulene, chamomile agents, acetylsalicylic acid derivatives or rhodanide
• - other vitamins such. As ascorbic acid, biotin, tocopherol or rutin
• - Mineral salts such. For example, manganese, zinc or magnesium salts.

Another important group of ingredients that may be included in the compositions of the invention are the so-called bioactive glasses.

The term "bioactive glasses" in the context of the present application comprises glasses which are biologically active and / or biologically active. For example, the biological effectiveness of a glass can be demonstrated in its antimicrobial properties, biologically active glass differs from conventional lime-sodium-silicate glasses in that it binds living tissue. Biologically active glass, for example, refers to a glass which forms a firm bond with body tissue, forming a hydroxylapatite layer. Bioactive glass is also understood to mean a glass which exhibits antimicrobial and / or anti-inflammatory action. The glass powder show against bacteria, fungi as well Viruses have a biocidal or a biostatic effect; are in contact with humans skin-friendly, toxicologically safe and especially suitable for consumption.

Oral and dental care and cleaning agents which are particularly preferred according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, more preferably from 0.5 to 3% by weight, and in particular 0.6 to 2 wt .-% of at least one bioactive glass.

The oral and dental care and cleaning compositions of this embodiment contain bioactive glass or glass powder or glass ceramic powder or composite materials comprising such a bioactive glass. For the purposes of the present application, glass powders are also understood as meaning granules and glass beads.

Due to the requirements for the toxicological safety of the glass and its suitability for consumption, the glass powder should be particularly pure. The burden of heavy metals is preferably low. Thus, the maximum concentration in the range of cosmetic formulations is preferably for Pb <20 ppm, Cd <5 ppm, As <5 ppm, Sb <10 ppm, Hg <1 ppm, Ni <10 ppm.

The unfused starting glass, which is contained directly in the preferred compositions according to the invention or is optionally used for the production of a glass ceramic which can be used according to the invention, contains SiO ₂ as a network former, preferably between 35-80% by weight. At lower concentrations, the spontaneous tendency to crystallize increases greatly and the chemical resistance decreases sharply. At higher SiO ₂ values, the crystallization stability may decrease and the processing temperature is significantly increased, so that the hot-forming properties deteriorate. Na ₂ O is used as a flux when melting the glass. At concentrations of less than 5%, the melting behavior is adversely affected. Sodium is a constituent of the phases which form during the ceramization and, if high crystalline phase fractions are to be adjusted by the ceramization, must be present in the glass in correspondingly high concentrations. K ₂ O acts as a flux when melting the glass. In addition, potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated. The P ₂ O ₅ content of silicate glasses, glass ceramics or composites can be used to adjust the chemical resistance of the glass and thus the ion emission in aqueous media. For Phospaht glasses, P ₂ O _{5 is} network images. The P ₂ O ₅ content is preferably between 0 and 80 wt .-%. In order to improve the meltability, the glass may contain up to 25% by weight of B ₂ O ₃ . Al ₂ O ₃ is used to adjust the chemical resistance of the glass.

To enhance the antimicrobial, in particular the antibacterial properties of the glass-ceramic antimicrobial acting ions such. B. Ag, Au, I, Ce, Cu, Zn in concentrations less than 5 wt .-% may be included.

Coloring ions such. As Mn, Cu, Fe, Cr, Co, V, may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.

Usually, the glass or the glass ceramic is used in powder form. The ceramization can be done either with a glass block or Glasribbons or with glass powder. After ceramization, the glass ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramification step. The grinding can be carried out both dry and in aqueous or non-aqueous grinding media. Usually, the particle sizes are less than 500 microns. As appropriate, particle sizes <100 microns or <20 microns have been found. Particularly suitable are particle sizes <10 microns and less than 5 microns and less than 2 microns, see below.

The bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the preferred compositions according to the invention comprise glasses which preferably comprise the following components: SiO ₂ : 35-80% by weight, Na ₂ O: 0-35% by weight, P ₂ O ₅ : 0-80% by weight, MgO: 0-5% by weight, Ag ₂ O: 0-0.5% by weight, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, TiO ₂ : 0-5 wt%, K ₂ O: 0-35 wt%, ZnO: 0-10 Wt .-%, Al ₂ O ₃ : 0-25 wt .-% and B ₂ O ₃ : 0-25 wt .-%.

Furthermore, the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%. A further glass composition may be as follows: SiO ₂ : 35-80 wt%, Na ₂ O: 0-35 wt%, P ₂ O ₅ : 0-80 wt%, MgO: 0-5 wt %, Ag ₂ O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, TiO ₂ : 0-5 wt% , K ₂ O: 0-35 wt .-%, ZnO: 0-10 wt .-%, Al ₂ O ₃ : 0-25 wt .-%, B ₂ O ₃ : 0-25 wt .-%, SnO : 0-5 wt%, CeO ₂ : 0-3 wt%, and Au: 0.001-0.1 wt%.

Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that the bioactive glass - based on its weight - has the following composition: SiO ₂ From 35 to 60% by weight, preferably 40 to 60% by weight, Na ₂ O 0 to 35% by weight, preferably From 5 to 30% by weight, K ₂ O 0 to 35% by weight, preferably 0 to 20% by weight, P ₂ O ₅ 0 to 10% by weight, preferably From 2 to 10% by weight, MgO 0 to 10% by weight, preferably 0 to 5% by weight, CaO 0 to 35% by weight, preferably From 5 to 30% by weight, Al ₂ O ₃ 0 to 25% by weight, preferably 0 to 5% by weight, B ₂ O ₃ 0 to 25% by weight, preferably 0 to 5% by weight, TiO ₂ 0 to 10% by weight, preferably 0.1 to 5 wt .-%.

As already mentioned above, the bioactive glass is preferably used in particulate form. Here are particularly preferred oral and dental care and cleaning agent according to the invention characterized in that the antimicrobial glass particle sizes <10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns having.

It has been found that the oral and dental care and cleaning compositions according to the invention can be further increased in their performance, when the agents contain salivationsfördernde substances. In particular, the antibacterial effect and with it the anti-caries effect and the action against gingivitis and / or periodontitis are thereby amplified.

Salivation is the production and release of saliva, in a broader sense also in an unphysiologically increased amount. Substances that stimulate salivary flow and increase the amount and / or release of saliva can come from a wide variety of substance classes.

An example of a suitable substance according to the invention is the pilocarpine, which may be present in the oral and dental care and cleaning compositions according to the invention.

Pilocarpin

pilocarpine

Further salivationsfördernde substances are in particular so-called Scharfstoffe, d. H. sharp tasting and / or a feeling of heat generating substances. Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they contain at least one pungent-tasting and / or heat-generating substance as the salivation-promoting substance.

As a salivation-promoting ingredient, the products of this embodiment of this invention contain a pungent-tasting and / or a feeling of heat-generating substance. These substances give the user a sharp, tingling, mouthwashing or heat-generating effect, d. H. they cause a sensation of warmth or burning, or tingling, beads, tickling or bubbling, thereby promoting salivation.

Products of this embodiment which are preferred according to the invention contain the pungent-tasting and / or a feeling of heat-generating substance (s) in amounts of from 0.00001 to 5% by weight, preferably from 0.0005 to 2.5% by weight .-%, more preferably from 0.001 to 1 wt .-%, particularly preferably from 0.005 to 0.75 wt .-% and in particular from 0.01 to 0.5 wt .-%, each based on the weight of the total composition.

• – 2E,4E-Decadiensäure-N-Methylamid
• – 2E,4E-Decadiensäure-N-Ethylamid
• – 2E,4E-Decadiensäure-N-n-Propylamid
• – 2E,4E-Decadiensäure-N-Isopropylamid
• – 2E,4E-Decadiensäure-N-n-Butylamid
• – 2E,4E-Decadiensäure-N-(1-Methylpropyl)-amid
• – 2E,4E-Decadiensäure-N-Isobutylamid
• – 2E,4E-Decadiensäure-N-tert-Butylamid
• – 2E,4Z-Decadiensäure-N-Methylamid
• – 2E,4Z-Decadiensäure-N-Ethylamid
• – 2E,4Z-Decadiensäure-N-n-Propylamid
• – 2E,4Z-Decadiensäure-N-Isopropylamid
• – 2E,4Z-Decadiensäure-N-n-Butylamid
• – 2E,4Z-Decadiensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z-Decadiensäure-N-Isobutylamid
• – 2E,4Z-Decadiensäure-N-tert-Butylamid
• – 2E,4E,8Z-Decatriensäure-N-Methylamid
• – 2E,4E,8Z-Decatriensäure-N-Ethylamid
• – 2E,4E,8Z-Decatriensäure-N-n-Propylamid
• – 2E,4E,8Z-Decatriensäure-N-Isopropylamid
• – 2E,4E,8Z-Decatriensäure-N-n-Butylamid
• – 2E,4E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4E,8Z-Decatriensäure-N-Isobutylamid
• – 2E,4E,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,4Z,8Z-Decatriensäure-N-Methylamid
• – 2E,4Z,8Z-Decatriensäure-N-Ethylamid
• – 2E,4Z,8Z-Decatriensäure-N-n-Propylamid
• – 2E,4Z,8Z-Decatriensäure-N-Isopropylamid
• – 2E,4Z,8Z-Decatriensäure-N-n-Butylamid
• – 2E,4Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z,8Z-Decatriensäure-N-Isobutylamid
• – 2E,4Z,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,4E,8E-Decatriensäure-N-Methylamid
• – 2E,4E,8E-Decatriensäure-N-Ethylamid
• – 2E,4E,8E-Decatriensäure-N-n-Propylamid
• – 2E,4E,8E-Decatriensäure-N-Isopropylamid
• – 2E,4E,8E-Decatriensäure-N-n-Butylamid
• – 2E,4E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4E,8E-Decatriensäure-N-Isobutylamid
• – 2E,4E,8E-Decatriensäure-N-tert-Butylamid
• – 2E,4Z,8E-Decatriensäure-N-Methylamid
• – 2E,4Z,8E-Decatriensäure-N-Ethylamid
• – 2E,4Z,8E-Decatriensäure-N-n-Propylamid
• – 2E,4Z,8E-Decatriensäure-N-Isopropylamid
• – 2E,4Z,8E-Decatriensäure-N-n-Butylamid
• – 2E,4Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z,8E-Decatriensäure-N-Isobutylamid
• – 2E,4Z,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6Z,8E-Decatriensäure-N-Methylamid
• – 2E,6Z,8E-Decatriensäure-N-Ethylamid
• – 2E,6Z,8E-Decatriensäure-N-n-Propylamid
• – 2E,6Z,8E-Decatriensäure-N-Isopropylamid
• – 2E,6Z,8E-Decatriensäure-N-n-Butylamid
• – 2E,6Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6Z,8E-Decatriensäure-N-Isobutylamid
• – 2E,6Z,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6E,8E-Decatriensäure-N-Methylamid
• – 2E,6E,8E-Decatriensäure-N-Ethylamid
• – 2E,6E,8E-Decatriensäure-N-n-Propylamid
• – 2E,6E,8E-Decatriensäure-N-Isopropylamid
• – 2E,6E,8E-Decatriensäure-N-n-Butylamid
• – 2E,6E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6E,8E-Decatriensäure-N-Isobutylamid
• – 2E,6E,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6Z,8Z-Decatriensäure-N-Methylamid
• – 2E,6Z,8Z-Decatriensäure-N-Ethylamid
• – 2E,6Z,8Z-Decatriensäure-N-n-Propylamid
• – 2E,6Z,8Z-Decatriensäure-N-Isopropylamid
• – 2E,6Z,8Z-Decatriensäure-N-n-Butylamid
• – 2E,6Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6Z,8Z-Decatriensäure-N-Isobutylamid
• – 2E,6Z,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,6E,8Z-Decatriensäure-N-Methylamid
• – 2E,6E,8Z-Decatriensäure-N-Ethylamid
• – 2E,6E,8Z-Decatriensäure-N-n-Propylamid
• – 2E,6E,8Z-Decatriensäure-N-Isopropylamid
• – 2E,6E,8Z-Decatriensäure-N-n-Butylamid
• – 2E,6E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6E,8Z-Decatriensäure-N-Isobutylamid
• – 2E,6E,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-Methylamid
• – 2E,7Z,9E-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9E-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9E-Undecatriensäure-N-tert-Butylamid
• – 2E,7E,9E-Undecatriensäure-N-Methylamid
• – 2E,7E,9E-Undecatriensäure-N-Ethylamid
• – 2E,7E,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7E,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7E,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7E,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7E,9E-Undecatriensäure-N-isobutylamid
• – 2E,7E,9E-Undecatriensäure-N-tert-Butylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Methylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9Z-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9Z-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9Z-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9Z-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9Z-Undecatriensäure-N-tert-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-Methylamid
• – 2E,7Z,9E-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9E-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9E-Undecatriensäure-N-tert-Butylamid

As a pungent or a feeling of heat generating substance, a number of substances can be used. Preference is given in particular to N-alkyl-substituted amides of unsaturated carboxylic acids, for example

• 2E, 4E-decadienoic acid N-methylamide
• 2E, 4E-decadienoic acid N-ethylamide
• 2E, 4E-decadienoic acid-Nn-propylamide
• 2E, 4E-decadienoic acid N-isopropylamide
• 2E, 4E-decadienoic acid-Nn-butylamide
• 2E, 4E-decadienoic acid N- (1-methylpropyl) -amide
• 2E, 4E-decadienoic acid N-isobutylamide
• 2E, 4E-decadienoic acid N-tert-butylamide
• 2E, 4Z-decadienoic acid N-methylamide
• 2E, 4Z-decadienoic acid N-ethylamide
• 2E, 4Z-decadienoic acid-Nn-propylamide
• 2E, 4Z-decadienoic acid N-isopropylamide
• 2E, 4Z-decadienoic acid-Nn-butylamide
• 2E, 4Z-decadienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z-decadienoic acid N-isobutylamide
• 2E, 4Z-decadienoic acid N-tert-butylamide
• 2E, 4E, 8Z-decatrienoic acid N-methylamide
• 2E, 4E, 8Z-decatrienoic acid N-ethylamide
• 2E, 4E, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 4E, 8Z-decatrienoic acid N-isopropylamide
• 2E, 4E, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 4E, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4E, 8Z-decatrienoic acid N-isobutylamide
• 2E, 4E, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 4Z, 8Z-decatrienoic acid N-methylamide
• 2E, 4Z, 8Z-decatrienoic acid N-ethylamide
• 2E, 4Z, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 4Z, 8Z-decatrienoic acid N-isopropylamide
• 2E, 4Z, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 4Z, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z, 8Z-decatrienoic acid N-isobutylamide
• 2E, 4Z, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 4E, 8E-Decatrienoic acid N-methylamide
• 2E, 4E, 8E-decatrienoic acid N-ethylamide
• 2E, 4E, 8E-decatrienoic acid-Nn-propylamide
• 2E, 4E, 8E-decatrienoic acid N-isopropylamide
• 2E, 4E, 8E-decatrienoic acid-Nn-butylamide
• 2E, 4E, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4E, 8E-decatrienoic acid N-isobutylamide
• 2E, 4E, 8E-Decatrienoic acid N-tert-butylamide
• 2E, 4Z, 8E-decatrienoic acid N-methylamide
• 2E, 4Z, 8E-decatrienoic acid N-ethylamide
• 2E, 4Z, 8E-decatrienoic acid-Nn-propylamide
• 2E, 4Z, 8E-decatrienoic acid N-isopropylamide
• 2E, 4Z, 8E-decatrienoic acid-Nn-butylamide
• 2E, 4Z, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z, 8E-decatrienoic acid N-isobutylamide
• 2E, 4Z, 8E-decatrienoic acid N-tert-butylamide
• 2E, 6Z, 8E-decatrienoic acid N-methylamide
• 2E, 6Z, 8E-decatrienoic acid N-ethylamide
• 2E, 6Z, 8E-decatrienoic acid-Nn-propylamide
• 2E, 6Z, 8E-decatrienoic acid N-isopropylamide
• 2E, 6Z, 8E-decatrienoic acid-Nn-butylamide
• 2E, 6Z, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6Z, 8E-decatrienoic acid N-isobutylamide
• 2E, 6Z, 8E-decatrienoic acid N-tert-butylamide
• 2E, 6E, 8E-Decatrienoic acid N-methylamide
• 2E, 6E, 8E-decatrienoic acid N-ethylamide
• 2E, 6E, 8E-decatrienoic acid-Nn-propylamide
• 2E, 6E, 8E-decatrienoic acid N-isopropylamide
• 2E, 6E, 8E-decatrienoic acid-Nn-butylamide
• 2E, 6E, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6E, 8E-decatrienoic acid N-isobutylamide
• 2E, 6E, 8E-Decatrienoic acid N-tert-butylamide
• 2E, 6Z, 8Z-decatrienoic acid N-methylamide
• 2E, 6Z, 8Z-decatrienoic acid N-ethylamide
• 2E, 6Z, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 6Z, 8Z-decatrienoic acid N-isopropylamide
• 2E, 6Z, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 6Z, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6Z, 8Z-decatrienoic acid N-isobutylamide
• 2E, 6Z, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 6E, 8Z-decatrienoic acid N-methylamide
• 2E, 6E, 8Z-decatrienoic acid N-ethylamide
• 2E, 6E, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 6E, 8Z-decatrienoic acid N-isopropylamide
• 2E, 6E, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 6E, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6E, 8Z-decatrienoic acid N-isobutylamide
• 2E, 6E, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 7Z, 9E undecatrienoic acid N-methylamide
• 2E, 7Z, 9E undecatrienoic acid N-ethylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9E undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9E undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9E undecatrienoic acid N-tert-butylamide
• 2E, 7E, 9E undecatrienoic acid N-methylamide
• 2E, 7E, 9E undecatrienoic acid N-ethylamide
• 2E, 7E, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7E, 9E undecatrienoic acid N-isopropylamide
• 2E, 7E, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7E, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7E, 9E undecatrienoic acid N-isobutylamide
• 2E, 7E, 9E undecatrienoic acid N-tert-butylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-methylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-ethylamide
• 2E, 7Z, 9Z-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9Z-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9Z-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9Z-undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-tert-butylamide
• 2E, 7Z, 9E undecatrienoic acid N-methylamide
• 2E, 7Z, 9E undecatrienoic acid N-ethylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9E undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9E undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9E undecatrienoic acid N-tert-butylamide

Of course, other substitution patterns on the nitrogen atom are possible and preferred, for example, longer-chain n-alkyl radicals (... Nn-Pentylamid, ... Nn-pentylamide, ... Nn-pentylamide, ... Nn-pentylamide,. ..- Nn-pentylamide, ...- Nn-hexylamide, ...- Nn-heptylamide, ...- Nn-octylamide, ...- Nn-nonylamide, ...- Nn-decylamide, ... -Nn-undecylamide, ... -Nn-dodecylamide, ... -Nn-tridecylamide, etc.) or disubstituted... N, N-dialkylamides such as... N, N-dimethylamide,... N, N-diethylamide,... N, N-di-n-propylamide,... N, N-diisopropylamide,... N, N-di-n-butylamide,... N-di (1-methylpropyl) amide,... N, N-diisobutylamide,... N, N-di-tert-butylamide,... N, N-methyl-ethylamide,... N, N-methyl-n-propylamide, N, N-methyl-isopropylamide, N, N-ethyl-n-propylamide, N, N-ethyl-isopropylamide, etc. ,

2E,4E,8Z-Decatriensäure-N-isobutylamid (N-Isobutyl-2E,4E,8Z-decatrienamid, auch Isoaffinin genannt):

2E,7Z,9E-Undecatriensäure-N-isobutylamid (N-Isobutyl-2E,7Z,9E-undecatrienamid):

2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin):

2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin):

Ferulasäureamide, beispielsweise Ferulasäure-N-Vanillylamid:

N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloylmethoxytyramin):

N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloylmethoxytyramin):

N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-propansäureamid (Dihydroferuloylmethoxytyramin):

N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloyldopamin):

N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloyldopamin):

N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2E)-propensäureamid (trans-Caffeoyltyramin):

N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)-propensäureamid (cis-Caffeoyltyramin):

N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans-Rubenamin):

N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4-dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin):

Among the compounds mentioned, some are particularly preferred in the context of the present invention. These are listed below: 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (N-isobutyl-2E, 6Z, 8E-decatrienamide, also called spilanthol or affinin):

2E, 4E, 8Z-Decatrienoic acid N-isobutylamide (N-isobutyl-2E, 4E, 8Z-decatrienamide, also called isoaffinin):

2E, 7Z, 9E-undecatrienoic acid N-isobutylamide (N-isobutyl-2E, 7Z, 9E-undecatrienamide):

2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin):

2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin):

Ferulic acid amides, for example ferulic acid N-vanillylamide:

N- [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) -propenoic acid amide (trans -feruloylmethoxytyramine):

N- [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloylmethoxytyramine):

N- [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) -propanoic acid amide (dihydroferuloylmethoxytyramine):

N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) -propenoic acid amide (trans -feruloyldopamine):

N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloyldopamine):

N- [2- (4-Hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2E) -propenoic acid amide (trans-caffeoyltyramine):

N- [2- (4-Hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) -propenoic acid amide (cis-caffeoyltyramine):

N- [2- (3,4-Dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide (trans-Rubenamine):

N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide (cis-Rubenamine):

Other useful in the context of the present invention Scharfstoffe are, for example, extracts of natural plants. Hot-tasting herbal extracts can be any physiologically harmless herbal extracts that produce a sharp or warm sensory impression. Pepper extract (Piper ssp., In particular Piper nigrum), water pepper extract (Polygonum ssp., In particular Polygonum hydropiper), extracts of Allium ssp. Are preferred as pungent-tasting plant extracts. (especially onion and garlic extracts), extracts of radish (Raphanus ssp.), horseradish extracts (Cochlearia armoracia), extracts of black (Brassica nigra), wild or yellow mustard (Sinapis ssp., especially Sinapis arvensis and Sinapis alba), Bertram root extracts (Anacyclus ssp., In particular Anacyclus pyrethrum L.), sun-hatch extracts (Echinaceae ssp.), Extracts of Szechuan pepper (Zanthoxylum spp., In particular Zanthoxylum piperitum), spilanthate extract (Spilanthes spp., In particular Spilanthes acmella), chile extract (Capsicum ssp. , in particular Capsicum frutescens), grains of paradise extract (Aframomum ssp., especially Aframomum melegueta [Rose] K. Schum.), ginger extract (Zingiber ssp., in particular Zingiber officinale) and Galanga extract (Kaempferia galanga or Alpinia galanga).

A particularly suitable substance is the gingerol derived from the ginger extract:

It is also possible to use N-ethyl-p-menthane-3-carboxamide (N-ethyl-5-methyl-2-isopropylcyclohexanecarboxamide):

Other pungent or a feeling of heat generating substances may, for. B. be capsaicin, dihydrocapsaicin, gingerol, paradole, shogaol, piperine, carboxylic acid N-vanillylamide, especially nonanoic acid-N-vanillylamid, 2-alkeneamic, in particular 2-nonenoic acid-N-isobutylamide, 2-nonenoic acid-N-4-hydroxy 3-methoxyphenylamide, alkyl ethers of 4-hydroxy-3-methoxybenzyl alcohol, in particular 4-hydroxy-3-methoxybenzyl n-butyl ether, alkyl ethers of 3-hydroxy-4-methoxybenzyl alcohol, alkyl ethers of 3,4-dimethoxybenzyl alcohol, alkyl ethers of 3- Ethoxy-4-hydroxybenzyl alcohol, alkyl ethers of 3,4-methylenedioxybenzyl alcohol, nicotinaldehyde, methyl nicotinate, propyl nicotinate, 2-butoxyethyl nicotinate, benzyl nicotinate, 1-acetoxychavicol, polygodial or isodrimeninol.

• a. 2E,6Z,8E-Decatriensäure-N-isobutylamid (Spilanthol) und/oder
• b. 2E,4E,8Z-Decatriensäure-N-isobutylamid und/oder
• c. 2E,7Z,9E-Undecatriensäure-N-isobutylamid und/oder
• d. 2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin) und/oder
• e. 2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin) und/oder
• f. Ferulasäure-N-Vanillylamid und/oder
• g. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloylmethoxytyramin) und/oder
• h. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloylmethoxytyramin) und/oder
• i. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-propansäureamid (Dihydroferuloylmethoxytyramin) und/oder
• j. N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloyldopamin) und/oder
• k. N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloyldopamin) und/oder
• l. N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2E)-propensureamid (trans-Caffeoyltyramin) und/oder
• m. N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)-propensäureamid (cis-Caffeoyltyramin) und/oder
• n. N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans-Rubenamin) und/oder
• o. N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4-dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin)

enthalten.Preferred remineralizing products according to the invention are characterized in that they contain at least one Scharfstoff from the group of N-alkyl-substituted amides of unsaturated carboxylic acids, preferably

• a. 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (Spilanthol) and / or
• b. 2E, 4E, 8Z-decatrienoic acid N-isobutylamide and / or
• c. 2E, 7Z, 9E-undecatrienoic acid N-isobutylamide and / or
• d. 2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin) and / or
• e. 2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin) and / or
• f. Ferulic acid N-vanillylamide and / or
• G. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) -propenoic acid amide (trans -feruloylmethoxytyramine) and / or
• H. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloylmethoxytyramine) and / or
• i. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) -propanoic acid amide (dihydroferuloylmethoxytyramine) and / or
• j. N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxy-phenyl) - (2E) -propenoic acid amide (trans -feruloyldopamine) and / or
• k. N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloyldopamine) and / or
• l. N- [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2E) -propeneamide (trans-caffeoyltyramine) and / or
• m. N- [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) -propenoic acid amide (cis-caffeoyltyramine) and / or
• n, N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide (trans-Rubenamine) and / or
• o. N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide (cis-Rubenamine)

contain.

In addition to or in place of the above-mentioned sharp substances, other pungent-tasting and / or a feeling of heat-generating substances may also be incorporated into the products according to the invention.

erwiesen, in der R1 und R2 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃ und R3 und R4 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂.Particularly suitable within the scope of the present invention are alkyl-substituted dioxanes of the formula

proved, in which R1 and R2 are independently selected from -H, -CH _3, -CH ₂ CH ₃ and R3 and R4 are independently selected from -H, -CH _3, -CH ₂ CH _3, -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ .

erwiesen, in der R5 für -CH₃ oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen und R6 für -CH₃ oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen oder eine Alkoxygruppe mit 1 bis 3 Kohlenstoffatomen stehtAs further particularly suitable in the context of the present invention phenyl esters of the formula

proved, in which R 5 is -CH ₃ or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms, and R6 is _-CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 Carbon atoms

erwiesen, in der R7 bis R12 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂, -CH₂CH₂CH₂CH₃, -CH₂CH(CH₃)₂, -CH(CH₃)CH₂CH_{3 ,} -C(CH₃)₃ oder R9 und R10 zusammen eine chemische Bindung oder eine Gruppe -(CR13R14)_x bedeuten, worin x für die Werte 1 oder 2 steht und R13 und R14 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂, -CH₂CH₂CH₂CH₃, -CH₂CH(CH₃)₂, -CH(CH₃)CH₂CH₃, -C(CH₃)₃ Further particularly suitable within the scope of the present invention are carvone acetals of the formula

in which R 7 to R 12 are independently selected from -H, -CH ₃ , -CH ₂ CH ₃ , -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ , -CH ₂ CH ₂ CH ₂ CH ₃ , -CH ₂ CH (CH ₃ ) ₂ , -CH (CH ₃ ) CH ₂ CH _{3 ,} -C (CH ₃ ) ₃ or R 9 and R 10 together _x is (CR13R14), wherein x is the values 1 or 2 and R13 and R14 are independently selected from -H, -CH _3, -CH ₂ CH _3, -CH ₂ CH ₂ CH - a chemical bond or a group ₃ , -CH (CH ₃ ) ₂ , -CH ₂ CH ₂ CH ₂ CH ₃ , -CH ₂ CH (CH ₃ ) ₂ , -CH (CH ₃ ) CH ₂ CH ₃ , -C (CH ₃ ) ₃

The compositions according to the invention may contain calcium glycerophosphate (s) as remineralizing component. The glycerophosphoric acid is a dibasic acid which occurs in two isomeric forms, depending on whether the phosphoric acid group is bound to a terminal or the medial OH group of glycerol. The form in which the phosphoric acid moiety is bonded to a terminal OH group of the glycerol is also referred to as the alpha isomer, the form in which the phosphoric acid moiety is bonded to the medial OH group of the glycerol, also referred to as the beta isomer.

sowie sn-Glycerol-3-phosphorsäure

auf.The alpha isomer is additionally optically active and occurs in the two enantiomeric forms sn-glycerol-1-phosphoric acid

as well as sn-glycerol-3-phosphoric acid

on.

The prefix sn for glycerol derivatives is "stereospecifically numbered" and requires that the 2-hydroxy group be pointing to the left in the Fischer projection used above. Glycerol-2-phosphate is not optically active. The glycerophosphoric acids are about as strong as phosphoric acid.

According to the invention, the use of the alpha isomer is preferred, regardless of which of the two enantiomers is used. If the use of enantiomerically pure compounds is desired, the calcium salt of sn-glycerol-3-phosphoric acid is preferably used.

In summary, oral and dental care and cleaning compositions according to the invention which contain calcium salts of the glycerophosphoric acids of the formulas (Ia) and (Ib) are preferred HO-CH ₂ -CH (OH) -CH ₂ -OP (O) O ₂ ^2- Ca ²⁺ (Ia) HO-CH ₂ -CH (OP (O) O ₂ ^2- ) -CH ₂ -OH Ca ²⁺ (Ib).

In this case, particularly preferred mouth and dental care and cleaning agents according to the invention are characterized in that the weight ratio of the calcium salts of the formulas (Ia) to (Ib) above 50:50, preferably above 60:40, more preferably above 70:30 and in particular above 80:20.

The use of calcium glycerophosphates within narrower ranges is preferred. Preferred oral and dental care and cleaning compositions according to the invention contain - based on their weight - 0.01 to 2.5 wt .-%, preferably 0.05 to 2.0 wt .-%, particularly preferably 0.1 to 1, 0 wt .-%, more preferably 0.11 to 0.75 wt .-% and in particular 0.12 to 0.5 wt .-% calcium glycerophosphate.

• – Verringerung und/oder kosmetischen Behandlung von Karies,
• – Verringerung und/oder kosmetischen Behandlung von Gingivitis oder Parodontitis und/oder
• – Verringerung und/oder kosmetischen Behandlung von Halitosis.
• – Senkung der Zahnempfindlichkeit und/oder
• – Senkung der Zahnempfindlichkeit gegen süße Speisen und Getränke und/oder
• – Senkung der Zahnempfindlichkeit gegen saure Speisen und Getränke und/oder
• – Senkung der Zahnempfindlichkeit gegen heiße Speisen und Getränke und/oder
• – Senkung der Zahnempfindlichkeit gegen kalte Speisen und Getränke und/oder
• – Senkung der Zahnempfindlichkeit gegen taktile Reize.

Another object of the present invention is the use of vegetable extracts in oral and dental care and cleaning agents for

• Reduction and / or cosmetic treatment of caries,
• Reduction and / or cosmetic treatment of gingivitis or periodontitis and / or
• - Reduction and / or cosmetic treatment of halitosis.
• - Reduction of tooth sensitivity and / or
• - Reduction of tooth sensitivity to sweet foods and drinks and / or
• - Reduction of tooth sensitivity to acid foods and drinks and / or
• - Reduction of tooth sensitivity to hot food and drinks and / or
• - Reduction of tooth sensitivity to cold foods and drinks and / or
• - Reduction of tooth sensitivity to tactile stimuli.

With respect to preferred embodiments of the use according to the invention mutatis mutandis applies to the means of the invention.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 2419384 [0015]
• US 3122483 [0015]

Claims (10)

Oral and dental care and cleaning compositions, containing - based on its weight - 0.00001 to 10 wt .-% vegetable extract (s). Oral and dental care and cleaning composition according to Claim 1, characterized in that it contains 0.00005 to 2.5% by weight, preferably 0.0001 to 2.0% by weight, particularly preferably 0.0005 to 1, 0 wt .-%, more preferably 0.001 to 0.75 wt .-% and in particular 0.01 to 0.5 wt .-% vegetable extract (s). Mouth and dental care and cleaning agent according to one of claims 1 or 2, characterized in that it contains at least one extract from the group artichoke extract, broccoli extract, asparagus extract, cucumber extract, beetroot extract, avocado extract, eggplant extract, spinach extract, tomato extract, zucchinia extract, celery extract, Mangold extract, carrot extract contains. Mouth and dental care and cleaning agent according to one of claims 1 to 3, characterized in that it contains at least one vegetable juice from the group rhubarb juice, kohlrabi juice, celeriac juice, carrot juice, beetroot juice, onion juice, leek juice, garlic juice, white cabbage juice, asparagus juice, spinach juice , Chard juice, tomato juice, cucumber juice, pumpkin juice, pea juice, bean juice, artichoke juice, cauliflower juice, kale juice, red cabbage juice, broccoli juice, Brussels sprouts juice. Mouth and dental care and cleaning agent according to one of Claims 1 to 4, characterized in that it contains 0.5 to 9.5% by weight, preferably 1 to 9% by weight, more preferably 2 to 8% by weight. , even more preferably 3 to 7 wt .-% and in particular 4 to 6 wt .-% potassium salt (s). Mouth and dental care and cleaning agent according to one of Claims 1 to 5, characterized in that it contains less than 60% by weight, preferably less than 55% by weight, more preferably less than 50% by weight and in particular less than Contains 45 wt .-% water. Mouth and dental care and cleaning agent according to one of claims 1 to 6, characterized in that it - based on its weight - 10 to 60 wt .-%, preferably 12.5 to 50 wt .-%, particularly preferably 15 to 45 Wt .-% and in particular 20 to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1,2-Propylenglycol .-% contains. Oral and dental care and cleaning agent according to one of claims 1 to 7, characterized in that it additionally cleaning body, preferably silicic acids, aluminum hydroxide, alumina, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ · 2H ₂ O), sodium aluminum silicates, in particular Zeolite A, organic polymers, in particular polymethacrylates or mixtures of these friction bodies, preferably in amounts of 1 to 30 wt .-%, preferably from 2.5 to 25 wt .-% and in particular from 5 to 22 wt .-%, each based on the entire remedy, contains. Oral and dental care and cleaning agent according to one of claims 1 to 8, characterized in that it additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts of 0 , 01 to 5 wt .-%, preferably from 0.1 to 2.5 wt .-% and in particular from 0.2 to 1.1 wt .-%, each based on the total agent contains. Use of vegetable extracts in oral and dental care and cleaning products for Reduction and / or cosmetic treatment of caries, Reduction and / or cosmetic treatment of gingivitis or periodontitis and / or - Reduction and / or cosmetic treatment of halitosis. - Reduction of tooth sensitivity and / or - Reduction of tooth sensitivity to sweet foods and drinks and / or - Reduction of tooth sensitivity to acid foods and drinks and / or - Reduction of tooth sensitivity to hot food and drinks and / or - Reduction of tooth sensitivity to cold foods and drinks and / or - Reduction of tooth sensitivity to tactile stimuli.