DE102011009798A1 - Balneological lipid-containing probiotic preparations for cosmetic / dermatological / medical applications - Google Patents

Abstract

The present invention relates to solid or liquid cosmetic, dermatological or medical balneological preparations for bathing or showering, which are essentially water-free (with a low water content of less than 1% by weight), and a lipid content with preferably at least one liquid lipid, furthermore dispersants , and a content of probiotic active substances, selected primarily from bacteria of the genus Lactobacillus and Bifidobacteria. When using these preparations, surprisingly contacted skin areas can be topically supplied with the probiotic active ingredients in the sense of a nourishing effect by maintaining and possibly rebuilding their healthy microbial status, while at the same time they are also cleaned and supplied with lipids. The preparations have a stability of the microorganisms required for the described active effect without further special measures for this.

Description

Subject of the invention

The present invention relates to solid or liquid cosmetic, dermatological or medical balneological preparations for bathing or showering, which are substantially free of water (with a low water content of less than 1% by weight), and a lipid content with preferably at least one liquid lipid, furthermore dispersants , and a content of probiotic agents selected mainly from bacteria of the genus Lactobacillus and Bifidobacteria, have. Surprisingly, when using these preparations, the skin can be supplied with the probiotic active ingredients in a holistic manner over the entire surface, including the mucous membranes, in the sense of a nourishing effect by maintaining and possibly rebuilding their healthy microbial status, while at the same time being purified and with lipids is supplied. In this case, the preparations have a required for the effect described effect stability of the microorganisms without further special measures for this purpose.

Background of the invention

Balneological additives for use in the tub or shower have long been known. In this case, water-free, in particular oil-containing products of water-containing products are distinguished, which may have different consistencies of liquid to gel depending on the additives. They mainly contain surfactants for cleansing the skin, and preferably lipidic substances, in order to rebuild the lipid film removed by the use of water and surfactants. Preference is given to using essential oils / extracts depending on the intended effect. Non-aqueous formulations containing liposome-forming substances are also particularly suitable. As a result, an improved drug delivery and thus a higher efficacy in the application should be made.

Probiotics are preparations containing viable microorganisms, which in particular can be used orally and thereby exert a health-promoting influence by improving the internal microbial status. More recently, products containing microorganisms have also been described which can be applied topically for the treatment of bacterial or fungal infection or for the disinfection of surfaces. That's how it describes EP 1629846 A2 a composition for topical therapeutic skin / mucous membrane application e.g. In the form of an oil or a powder containing a Bacillus strain. From the parallel DE 69832267 T4 is an antimicrobial composition with a Bacillus species (B. coagulans) e.g. B. with oil or powder as carriers, which are used in particular together with growth-promoting fructo-oligosaccharides, for the treatment of a bacterial infection or skin diseases such as acne.

Bacillus species are known to be spore-forming, mobile and thus relatively stable microorganisms, while z. B. Lactobacilli are immobile and not spore-forming. The problem with the use of probiotic organisms is that on the one hand in the basis of a sufficient number of viable germs should be present and on the other hand must be storable. Therefore, in the case of products to be administered orally, coatings or microencapsulation are also proposed, see DE 69634171 T4 , From the EP 0131114 B1 describes a particular drying process for preserving a particular Lactobacillus species for use in food production. According to the US 2008/0107699 describes probiotic preparations for antimicrobial application on surfaces and for hand disinfection, which are used in and with different bases by being applied to the surface and remain there. For this purpose, a suitable basis is chosen such as an oil in water lotion or a spray with liposomally packed germs or a surfactant-free oil (olive oil, almond oil, grapeseed oil), in particular synthetically processed sesame oil. In the latter, the germs (especially acid-stable Lactobacillus bacteria) can be encapsulated in an amount of 10 ⁹ / ml of oil. Surfactant dispersants are not used here in anhydrous bases. If water-containing products are used, it is preferable to add fructo-oligosacchride (see paragraphs 0038, 0039). If an anhydrous base with surfactants is to be used, the base is first prepared separately, for. B. bath oil from mineral oil and Laureth 4 as in the above DE 69832267 T2 described. This base is added to the bathing liquor and then added to the separately present dry bacillus coagulum spores for disinfection, so that there are about 5 × 10 ⁹ , see paragraphs 0068 and 0101, DE 69832267 T2 , The separate administration allows a certain stability of the microorganisms, which is essential in particular for the therapeutic antimicrobial treatment and disinfection.

Thus, according to the prior art, either very specific organisms have to be selected, or encapsulation techniques have to be used, or else the user is obliged to prepare the bath liquor by using a wide variety of individually packaged preparations, which may be a critical factor, in particular in the case of therapeutic antimicrobial treatment. However, it would be desirable if a preparation could be provided especially for cleaning and care, in which the desired probiotic active ingredient, regardless of a specific type, already contained in a suitable, especially with respect to the microbial skin status' conservative amount and thus in the application especially in the bath despite the presence of surfactant-acting dispersant uniform distribution would be possible. Furthermore, such a ready-to-use preparation should also have sufficient stability to ensure an equally sufficient amount of viable microorganism.

Object of the invention

The present invention has for its object to provide a simply hand zuhabende preparation for balneological applications with cleaning effect in a simple way, with which the microbial status of the skin despite the cleaning process during bathing received, if necessary, can also be improved, while a Greasing takes place, resulting in a total nourishing effect.

Solution of the task

This object is achieved in accordance with the invention by providing a flowable, above all liquid or solid balneological preparation with a free-flowing, especially liquid, substantially anhydrous lipid base or with a substantially anhydrous solid lipid-containing base based on a carrier selected from mineral salt, Effervescent salt, urea, provides. Herein further incorporated are a content of probiotic microorganisms in an amount of 10 ² to 10 ⁹ germs / g (weight) of the preparation together with one or more surfactant dispersants selected from nonionic surfactants, anionic surfactants or mixtures thereof. The probiotics are selected from bacteria of the genera Lactobacillus, Bifidus, or mixtures thereof. Optionally, the base may comprise active ingredients such as essential oils, vitamins, as well as conventional galenic additives in an amount of 0, preferably 0.1 to 30 wt.%, Based on the total weight of the mixture.

Substantially anhydrous in the present application means a water content which is possible from the raw materials used and which in total should not exceed 1% by weight and preferably less than 0.5% by weight, based on the total weight of the preparation. Preferably, the balneological preparations according to the invention do not comprise fructo-oligosaccharides, nor do the micro-organism used have to be encapsulated or provided with certain coatings to increase the stability. Although above all non-spore-forming microorganisms are used, they remain sufficiently stable, in particular if the said lipids are selected for this purpose. These include, in particular, natural liquid oils containing at least 50% of oleic and linoleic acids, hydrogenated derivatives thereof and mixtures of these lipid components. Preferably, vesicle formers such as lecithins may also be present.

Preferably, the liquid preparation (with substantially anhydrous liquid lipid-containing base) comprises 40 to 90, especially 50 to 90 wt.% Liquid lipids (especially natural oils with an oil and linoleic acid content (Σ) of at least 50 wt.%) Or mixtures Of these), 1 to 30, especially 1 to 20, in particular 1 to 15 wt.% Dispersant, 10 ² to 10 ⁹ / g preparation probiotic germs, 0 to 20, especially 0.1 to 20 or 0.1 to 15 % By weight of additives and optionally (0 to 15, especially 0.5 to 15% by weight) of additional active ingredients and less than 1% by weight of water.

In another form, solid products (with lipid-containing substantially anhydrous solid base) are prepared from 30, especially 40 to 95 wt.%, Preferably 60 to 90 wt.% Of one or more mineral salts such as chlorides, sulfates of alkali and alkaline earth metals (NaCl, CaSO ₄ , MgSO ₄ , KBr), and one or more lipids (1 to 30, especially 1.5 to 20, in particular 2 to 15 wt.%), Selected from liquid lipids = natural oils, hydrogenated derivatives thereof or preferably also mixtures thereof; 0.5 to 15, especially 1 to 8,% by weight of dispersant (s), 10 ² to 10 ^{9 of} probiotic germs / g of preparation and optionally additives (eg 0.1 to 20% by weight,), Additional active ingredients (eg 0.5 to 15, especially up to 10 wt.%).

In another embodiment of preparations according to the invention on solid lipid-containing basis, a part or the total amount of mineral salts can be replaced by a suitable effervescent composition and the Preparation can also be tabletted. Such a preparation may in this respect 20-85%, in particular 60-80%, of a carbonate / bicarbonate-acid mixture, 0 to 20 wt. Mineral salts as described above; 1-25% by weight, especially 1 to 15% by weight, in particular 1.5 to 8% by weight, of one or more lipids as mentioned; 0.1-20%, especially 0.1-5%, of one or more dispersants; 10 ² to 10 ⁹ probiotic germs / g of preparation and 0-20%, preferably 0.1 to 20% by weight of additives and / or additional active ingredients (eg 0.5 to 15, especially up to 10% by weight) ,

In a further embodiment of solid preparations with lipid-containing substantially anhydrous (solid) base may also be urea, z. B. 80 to 95 wt.%, Are used. Such preparations further comprise one or more lipids ( 1 to 25% by weight, especially 2 to 17% by weight) selected from liquid lipids = oils, hydrogenated derivatives thereof, or preferably mixtures thereof; 0.5 to 15, especially 1 to 8 wt.%, Dispersant, 10 ² to 10 ⁹ probiotic germs / g preparation and optionally additives (eg., 0.1 to 20 wt.%,), Additional active ingredients (eg B. 0.5 to 15, especially up to 10 wt.%).

For this and the o. G. Solid preparation forms are colloids such as dextrins, plant colloids or higher molecular weight cellulose derivatives preferred additives.

The dispersants are selected from nonionic, in particular polyoxy-preferably polyethoxylated, or anionic surface-active substances, in particular from one or more of each of these two groups.

Surprisingly, it has been shown that, despite the relatively short contact time of the skin in the bath and above all despite the proportion of dispersants, which usually degrease and sterilize the surface of the skin as surfactants and thus can also act germ-destabilizing, a high supply of those containing in the preparations Microorganisms can be done, which is not locally limited, but holistic, including the mucosa, takes place. As a result, it is possible to maintain the skin-healthy microbial status of the skin despite the bathing and cleaning process (ie preserved) and, if appropriate, also to improve it, depending on the starting situation of the user. Without wishing to be bound by theory, it is assumed that the adhesion of the microorganisms is favored with the abovementioned dispersants in interaction with the abovementioned lipids, so that after the first cleaning process, the microorganisms present in the preparation become better due to the lipids deposited on the skin attached (see also example of the present application). Since the skin area is generally achieved nationwide, there is thus a holistic maintenance or, if necessary, reconstruction of the skin-healthy microbial status. Thus, with regard to the skin situation changed by the use of water alone, by the lipids used on the one hand and by the probiotic active ingredients on the other hand, a double care effect takes place. Surprisingly, it is neither necessary for stable spore-forming germs to be used, nor for encapsulation of the germs nor for any other coating stabilizations to be carried out.

Further explanation of the invention

The present invention relates to balneological preparations, especially for cosmetic, and also for dermatological applications or possibly also for medical applications, depending on additional active components and combinations. Therefore, in addition to the content of 10 ² to 10 ⁹ , preferably 10 ³ to 10 ⁹ , in particular 10 ⁵ to 10 ⁹ germs / g Preparation of probiotic microorganisms suitable application-related or product-related additives and optionally additional active ingredients as described below. The application is carried out by pouring the liquid or sprinkling of the solid preparation in the bathing liquor or directly, z. B. in the shower.

Description of the ingredients

1. Lipids

The preparations of the present invention initially comprise one or more lipids in an amount adapted to the particular product and form the liquid base in the case of liquid products.

By lipid component according to the present application is meant only the amount of lipids as described in this category. Other lipid-like or lipid-soluble substances which are or may be present in preparations according to the invention (such as additives, additional active ingredients) are not included in the lipid component designated according to the application and, if present, are present separately.

The lipids may be selected from the group comprising natural lipids, especially natural liquid oils and hydrogenated derivatives thereof, or mixtures thereof.

The lipids according to the invention (the lipid components) include, in particular, liquid lipids, in particular oils, selected especially from natural oils having a high content of oleic acid and (+) linoleic acid.

Particularly preferred lipids include, in particular, liquid oils whose total proportion (Σ) of oleic acid + linoleic acid is at least 50%, in particular more than 60% and very particularly preferably at least 75%. (Information on oleic acid-linoleic acid content of the above-described oils may, for example, the DAZ, 150th year, 02.09.2010, No. 35, pages 3925-3934 be removed).

It is further preferred if in a lipid mixture at least one substance with a total proportion (Σ) of oleic acid + linoleic acid of at least 75% by weight, preferably at least 80% by weight, is present.

Lipids suitable for preparations according to the invention are apricot kernel oil, avocado oil, borage seed oil, thistle oil, peanut oil, hazelnut oil, pumpkin seed oil, corn oil, almond oil, marula oil, macademia nut oil, poppy seed oil, evening primrose oil, olive oil, palm oil, pine nut oil, rice germ oil, sea buckthorn oil, sesame oil, soybean oil, sunflower oil, grapeseed oil, Walnut oil, wheat germ oil and the hydrogenated derivatives thereof such as hydrogenated sunflower oil, hydrogenated palm oil, hydrogenated soybean oil, hydrogenated peanut oil, hydrogenated olive oil or mixtures thereof.

For the preparations according to the invention suitable oils of the type described above are mainly selected from olive oil, sunflower oil, soybean oil, apricot kernel, grapeseed oil, hazelnut oil, poppy seed oil, peanut, almond, wheat germ, sesame safflower oil, avocado oil, borage seed oil, sea buckthorn oil, Corn oil, walnut oil, evening primrose oil, palm oil, pine nut oil, rice germ oil, pumpkin seed oil, marula oil, or mixtures of these oils or mixtures with the hydrogenated (rather semi-solid) derivatives thereof, in particular palm oil, sunflower oil and soybean oil (in each case hydrogenated).

Very particularly preferred liquid lipids are vegetable oils selected from almond oil, avocado oil, marula oil, apricot kernel oil, hazelnut oil, sea buckthorn oil, soybean oil or mixtures thereof.

Among the preferred hydrogenated lipid derivatives (waxy semi-solid or solid) or solid to waxy lipids are hydrogenated soybean oil, hydrogenated palm oil, hydrogenated sunflower oil or mixtures thereof.

The lipids are in preparations according to the invention preferably in a total amount of 25, especially 50 to 90 wt.%, Especially 60 to 85% by weight (flowable, liquid anhydrous preparations), or 1 to 30 wt.%, In particular 1 to 15, especially 1 to 8, especially 1.3 to 6 wt.% (Solid preparations) contain as described above.

In a particularly preferred embodiment, preparations according to the application comprise at least one liquid lipid, preferably selected from sunflower, soybean, olive oil, peach kernel, apricot kernel, grape seed, peanut, almond, mink, wheat germ, sesame thistle almond , Avocado oil, palm oil, pine nut oil, rice germ oil, macadamia nut oil, palm kernel oil, papaya oil, sea buckthorn oil (each having a total oleic acid oleic acid content (Σ) of at least 50% by weight), together with one or more vesicle formers, preferably selected from lecithins, phospholipids, sphingosines, Cerebrosides, ceramides or mixtures thereof as described below.

In a further advantageous embodiment, inventive, especially solid preparations comprise one or more liquid oils as described above together with one or more hydrogenated derivatives thereof as described, especially selected from sunflower oil, soybean oil and palm oil (each hydrogenated), or mixtures thereof with the above mentioned liquid oils.

In another preferred embodiment, one or more vesicle formers, z. B. selected from lecithins, phospholipids, sphingosines, cerebrosides, ceramides or mixtures thereof as described in more detail below.

2. Dispersant

The preparations further comprise one or more (surface-active) dispersants (surfactants). Suitable for this purpose are dispersants having an HLB value between 7 and 11 (such as W / O dispersants) and dispersants having an HLB value from 13 (such as O / W dispersant). Also suitable are specific oil-soluble, water-dispersible compositions having an HLB value between 7.5 and 12.5, as described below.

• a) nichtionischen Dispergiermitteln der Gruppe, umfassend:
• ai) (W/O)-Mittel mit einem HLB-Wert von 7–11, ausgewählt aus Cetearylalkohol, Glycerolstearat; niedrigpolyethoxylierten oder -propoxylierten bzw. auch gemischt niedrigpolyoxylierten C_8-22-Fettalkoholen mit einem Ethoxylierungsgrad und/oder Propoxylierungsgrad (EO/PO-Grad) von 1–7 EO;
• aii) öllösliche, in Wasser dispergierbare polyoxyethylierten C_8-22Fettalkohole/Fettsäuren mit einem HLB-Wert von 7,5 bis 12, vorzugsweise 7,5 bis 10 und einem EO-Grad von 1–15;
• aiii) (O/W) Mittel mit einem HLB-Wert von 13–25, ausgewählt aus höherpolyoxyethylierten/und/oder -propoxylierten C_8-22-Fettalkoholen; ethoxylierten und/oder propoxylierten C_12-22-Fettsäuren mit Ethoxylierungs- oder Propoxylierungsgraden von 8–25;
• aiv) Zuckerester oder Zuckerether von C_12-22-Fettsäuren oder C_8-22-Fettalkoholen; polyoxyethylierte und/oder polyoxypropylierte Zuckerester von C₁₂-C₁₈ Fettsäuren, wobei der EO bzw. PO Grad 8–25 beträgt; oder Mischungen hiervon;
• b) aus anionischen – Verbindungen der Gruppe, umfassend:
• bi) C_8-22Alkylsulfate, C_8-22-Alkylethersulfate bzw. deren Alkali- insbesondere Natriumsalze wie Natriumlaurylsulfat, Natriumlaurylethersulfat oder deren ethoxylierte/und/oder propoxylierte Derivate mit 1 bis 6 EO;
• bii) (Alkyl)-C₁₂-C₂₂-Fettalkohol-Aminosäureester-Verbindungen, insbesondere Alkalisalze hiervon, wobei die Aminosäuren ausgewählt sind aus Glycin, Taurin, oder Mischungen hiervon;

Preferably, the dispersant or dispersants are selected from:

• a) nonionic dispersants of the group comprising:
• ai) (W / O) agent having an HLB of 7-11 selected from cetearyl alcohol, glycerol stearate; low-polyethoxylated or -propoxylated or also mixed low- _polyoxylated C _{8-22 fatty} alcohols having a degree of ethoxylation and / or degree of propoxylation (EO / PO degree) of 1-7 EO;
• aii) oil-soluble, water-dispersible polyoxyethylated C _8-22 fatty alcohols / fatty acids having an HLB value of 7.5 to 12, preferably 7.5 to 10 and an EO degree of 1-15;
• aiii) (O / W) Agents having an HLB of 13-25 selected from higher polyoxyethylated / and / or propoxylated C _8-22 fatty alcohols; ethoxylated and / or propoxylated C _12-22 fatty acids having degrees of ethoxylation or propoxylation of 8-25;
• aiv) sugar esters or sugar ethers of C _12-22 fatty acids or C _8-22 fatty alcohols; polyoxyethylated and / or polyoxypropylated sugar esters of C ₁₂ -C ₁₈ fatty acids, wherein the EO or PO degree is 8-25; or mixtures thereof;
• b) anionic compounds of the group comprising:
• bi) C _8-22 alkyl sulfates, C _8-22 alkyl _ether sulfates or their alkali metal salts, in particular sodium salts, such as sodium lauryl sulfate, sodium lauryl ether sulfate or their ethoxylated / and / or propoxylated derivatives having 1 to 6 EO;
• bii) (alkyl) -C ₁₂ -C ₂₂ fatty alcohol amino acid ester compounds, in particular alkali salts thereof, wherein the amino acids are selected from glycine, taurine, or mixtures thereof;

As (W / O) dispersing components, those having an HLB value of 7-11, preferably 7.5 to 10 are preferably selected. These preferably include nonionic substances ai) such as fatty alcohols such as cetearyl alcohol, or monoglycerides such as glycerol stearate; furthermore low-polyethoxylated or -pro-polyoxylated or else mixed low-polyoxylated C _{8-22 -fatty} alcohols having a degree of ethoxylation and / or degree of propoxylation (EO / PO degree) of 1-5 EO. Preferred are low _polyoxylated C _{8-22 fatty} alcohols having an EO degree of 1-5. These include, in particular, macrogol (polyethylene glycol) lauryl ethers having 1 to 4 EO units such as laureth 2, laureth-3, laureth-4 or mixtures thereof.

As O / W dispersing components (aiii), those having an HLB of 13-40, especially 13-25, especially 13.5 to 20, especially 13.5-17, are preferably selected. These include, in particular, higher polyoxyethylated / and / or propoxylated C _{8-22 fatty} alcohols (especially alkyl C ₁₀ -C ₁₈ fatty alcohol alkoxylates) or such ethoxylated and / or propoxylated C _12-22 fatty acids having degrees of ethoxylation or propoxylation of 8 Or mixtures thereof as (HLB values in parentheses): polyoxypropylene (15) stearyl ether or, polyoxyethylene sorbitan monooleate (15.0), polyoxyethylene sorbitan monostearate or palmitate 15.0), polyoxyethylene stearyl ether (15.3), polyoxyethylene oleyl ether (15 , 3), polyoxyethylene oxypropylene monostearate (15.7), polyoxyethylene fatty alcohol ether (16.0), polyoxyethylene monostearate (HLB 15), and the like. Particular preference is given here to ethoxylated C _12-22 fatty acids or ethoxylated C _{8-22 fatty} alcohols _having degrees of ethoxylation of 10-20 (HLB value, for example, of 13 to 20, especially 13.5 to 18 ).

Also suitable may be sugar esters or sugar ethers of C _12-22 fatty acids or C _8-22 fatty alcohols (aiv). These include in particular sugar esters of C ₁₂ -C ₁₈ saturated, unsaturated, partially saturated fatty acids; polyoxyethylated and / or polyoxypropylated sugar esters of C ₁₂ -C ₁₈ fatty acids, wherein the EO or PO degree is 8-25. The sugar ethers include those of C ₈ -C ₂₀ saturated, unsaturated, partially saturated fatty alcohols; or of polyoxyethylated and / or polyoxypropylated sugar ethers of these C ₈ -C ₂₀ fatty alcohols. The EO or PO degree is between 8 and 25. Particularly suitable sugars are glucose, methyl glucose, sucrose and, as acids or alcohols, the C ₁₆ -C ₁₈ fatty acids / alcohols. Preference is given to ethoxylated products. The acid or alcohol components are derived primarily from aliphatic carboxylic acids / alcohols. These include in particular caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and also mixtures thereof or fatty alcohols (oleyl alcohol, lauryl alcohol, stearyl alcohol etc.).

In a further preferred embodiment, the dispersing components are selected from (bi) anionic compounds such as. B. C _8-22 alkyl sulfates or C _8-22 alkyl _ether sulfates or their alkali _metal salts in particular sodium, such as sodium lauryl sulfate, sodium lauryl ether.

Furthermore, the dispersing components can also be selected from (alkyl) -C ₁₂ -C ₂₂ fatty alcohol amino acid ester compounds (bii), in particular an alkali metal salt thereof, wherein the amino acids are selected from glycine, taurine, such as oleyl, lauryl taurate, Sodium methyloleyl taurate u. Ä .. These can be used as salts such. Alkali / alkaline-earth salts (Na / K-Ca, Mg-chlorode, sulfates, phosphates.) Amino acid ester compounds (bii) as described above are particularly suitable for solid preparations, and especially in combination with nonionic dispersants all lower or higher alkylated alkyl esters / ethers.

Other suitable dispersants (au) are, as mentioned, oil-soluble, water-dispersible polyoxyethylated fatty alcohols / fatty acids (alkyl chain length as described) having an HLB value of 7.5 to 12, preferably 7.5 to 10 and an EO degree of 1-15 as above all (EO degree in brackets):
Polyoxyethylene lauryl ether having 1 to 15 EO units, medium chain length such as polyoxyethylene (5) oleyl ether, polyoxyethylene (7) glyceryl cocoate, coconut fatty acid diethanolamide, mono / di / tri (alkyltetraglycol ether) / o / phosphonic acid ester, polyoxyethylene glycerol trioleate, polyoxyethylene sorbitan tristearate, polyoxypropylene (15) stearyl ether , Particular preference is given here to polyoxyethylene lauryl ethers having 1 to 4 EO units, polyoxyethylene (7) glycerol cocoate, coconut fatty acid diethanolamide or mixtures thereof, in particular also in combination with one or more abovementioned anionic dispersants.

Isethionates are preferably not used.

In general, it may be advantageous for solid formulations if dispersants having an HLB value of 7 to 11 and those having an HLB value of 13 to 25, in particular 13 to 19, in particular nonionic (eg W / O -) dispersants are combined with anionic (eg O / W) dispersants.

For liquid dosage forms, especially non-ionic dispersants, especially oxylated, especially ethoxylated alkyl esters or preferably ethoxylated alkyl ethers ai), aii) as described above, are used.

Particularly preferred dispersing components are selected from niedrigpolyethoxylierten or niedrigpolypropoxylierten or also mixed oxylierten C _12-18 fatty alcohols with a degree of ethoxylation / propoxylation (EO / PO degrees) 1-5, in particular having an EO degree of 2-4 as especially such lauryl ether components, in particular in combination with anionic agents such as C _8-22 alkyl sulfates, C _8-22 alkyl _ether sulfates and C _12-C18 fatty alcohol taurates, in particular sodium methyl oleyl taurate.

The dispersing components are present in one of the respective dosage form adapted (total) amount. The total amount of dispersants may be in solid products z. B. 1 to 12 wt.%, Preferably 1 to 10 wt.%, Especially 2 to 7 wt.%, In flowable (liquid) products 4 to 30 wt.%, Especially 4 to 25 wt%.

3. Probiotics

Probiotic bacteria which can be used in the present invention include in particular bacteria of the genera Lactobacillus and Bifido such as Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus delbrueckiil, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus jensenii; the Lactococcus genus including Lactococcus lactis (subsp. Lactis); Bifidobacterium LA-5 powder; Bifidobacterium longum, Bifidobacterium infantis, and Bifidobacterium bifidum. Preferably, the germs are not verkaspselt or are not used liposomal. Particularly suitable are as germs of the genus Lactobacillus acidophilus. Bifido nuclei, for. B. non-encapsulated, non-liposomal, such as Bifidobacterium LA-5 powder.

Specific examples of acid-tolerant bacteria useful in the present invention are Lactobacillus acidophilus La-14; Lactobacillus casei Lc-11; Lactobacillus paracasei Lpc-37; Lactobacillus plantarum Lp-115; and Lactobacillus rhamnosus L4-32; (from Danisco, USA, Madison, Wisc.).

Examples of suitable oxygen-tolerant bacteria according to the invention are B. lactis Bb12, (available from Chr. Hansen, Denmark) and B. lactis HN019 (DR10) (eg, commercially available from Danisco, USA, Madison, Wisc).

This o. G. Microorganisms are well known and commercially available.

Particularly suitable probiotics include, in particular, Lactobacilli, Bifidobacteria. Particularly preferred are the species Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus bifidum, Lactobacillus gasseri, Lactobacillus plantarum, Lactobacillus johnsonii, Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus crispatus, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium lactis , Bifidobacterium brevis, Bifidobacterium animalis, Bifidobacterium adolescentis, Bifidobacterium infantis, Lactococcus lactis or else mixtures thereof.

Such microorganisms are commercially available in a suitable form and known as such. They may preferably be used in a dried, non-microencapsulated form, although special coatings are not required. The bacterial species are generally present in pulverized form, revitalizable in an aqueous phase, preferably containing about 30 × 10 ⁹ viable germs per gram of dry matter. They are incorporated in the dosage form according to the invention (balneological preparation) in an amount such that a content of 10 ² to 10 ⁹ , preferably 10 ³ to 10 ⁸ , especially 10 ³ to 10 ⁶ germs probiotic or probiotic mixture / g preparation (corresponding up to 1% by weight). It is further preferred to use the microorganisms and not spores thereof.

4. Vesicle generator

Compositions according to the invention may also have vesicle formers. These vesicle (= liposome) -forming substances include, in particular, phospholipids such as lecithin (eg egg or soya lecithin such as, for example, commercially available products such as Phosal 50 SA, Phosal 40 MD and the like). , or phosphatidylcholine, or - diethanolamine, phosphatidylserine, phosphatidylinositol, e.g. As from soybean oilseed rape, cotton seed, egg, and mixtures thereof. Other suitable components for the formation of vesicles (liposomal structures) are sphingolipids (eg ceramides, cerebrosides, sphingosine, sphingomyelin). Such substances are commercially available. They may be in solid form (powder) or in liquid form, with or without suitable carrier. Depending on the preparation, solid or liquid derivatives can be used.

The amount of vesicle-forming lipid (liposomal component) is 0 to 5 wt.%, Above all, 0.1 to 5 wt.%, Preferably 0.3 to 3 wt.%. Particularly preferred are phospholipids, and among these lecithins, especially soybean lecithin, egg lecithin, or mixtures thereof.

If vesicle-forming agents are added, an even better balance of the bacterial status and also an improved lipid status of the skin can be achieved.

Preferred embodiments of the present invention therefore also comprise one or more liposomal components as described above, in particular phospholipids, lecithins, e.g. B. in an amount of 0.5 to 4 wt.%.

5. Additives

Depending on the galenic dosage form, additives are selected in amounts between 0 and 20% by weight, in particular 0.5 to 20% by weight, preferably 0.5 and 17% by weight. These include, depending on the form of preparation / dosage form especially consistency agents (including stabilizers, adsorbents, lubricants, lubricants and disintegrants, especially for solid dosage forms), dyes and perfumes.

Suitable consistency agents include C _12-22 fatty acid _partial esters of polyhydric C _2-6 alcohols such as diglycerides e.g. B. Glycerol distearate; Polyol C _12-22 fatty acid esters such as propylene glycol dicaprylates / dicaprate, or mixtures such as hexyldecanol and hexyldecyl laurate or possibly also waxes such as natural or bleached beeswax (C _20-40 alkyl stearate) or micro wax or hydrocarbon waxes such as mineral wax and fatty acid amides such as cocoamidobetaines or synthetic waxes such as cetyl palmitate or myristyl myristate, or stearyl stearates. Also suitable as a consistency agent and semi-solid natural waxes, eg. Eg jojoba oil or its substitute oleyl erucate; Jojoba oil, Shea butter or Illipe butter. Stabilizing agents include, for. B. stabilizing antioxidants. Other consistency regulators, especially for fixed Dosage forms are colloids of the type known for this purpose such as cellulose ethers such as methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, colloids such as guar gum, xanthan, Abil ^® grades (= Poloxamer-polysiloxane copolymers), starch, or starch derivatives, such as rice, Wheat, corn and potato starch, hydrophobically modified starches such as aluminum Starch Octenylsuccinate or mixtures thereof. Also suitable (especially for solid dosage forms) protein hydrolysates of plant and / or animal origin, such as. B. Wheat protein hydrolysates and collagen hydrolysates. Other suitable colloids are LB. Polyvinylpyrrolidone, methylcellulose and methylhydroxyethylcellulose. In addition, adsorbents such as cyclodextrin, dextrin, starch and / or finely divided silica or other silicon dioxide products, lubricants and lubricants and disintegrating agents such as talc, starch products, cellulose derivatives and carboxymethylated, cross-linked povidone or magnesium stearate, macrogol can be used.

Perfumes are z. As the following essential agents (oils, extracts) or synthetic agents such as perfumes, such as. As linalool, geraniol or rose oil.

Dyes are, for example, suitable for the purpose mentioned authorized in particular water-soluble dyes such. B. Cochenillerot, Patent Blue and Quinoline yellow, u. Ä., or natural water-soluble dyes such as beetroot extract, or chlorophyll.

These substances are known to those skilled in the art and can be selected according to their intended purpose (such as marine environment, green refreshment bath, yellow foot bath and the like).

Preservatives are not required in preparations of the invention and are preferably not used.

Acids such as lactic acid, citric acid, tartaric acid, acetic acid, hydrochloric acid, malic acid and the like can optionally be used, as long as the dosage form (eg effervescent salt) is required.

6. Additional active ingredients

Additional active ingredients, which may be present in a total amount of 0.1 to 20, especially up to 10 wt.%, Based on the total preparation, are in particular selected from essential oils, plant extracts with the respective effects known to those skilled as stimulating, calming, healing, anticoagulant, refreshing, invigorating and a. m. Other application-related agents such as circulation-promoting substances, hygienic / dermatological agents (antifungals, antiseptics), skin care agents can be used here. The essential oils / extracts include essential oils / extracts for cosmetic / dermatological or possibly medicinal bath additives, preferably selected from khaki leaves, mango, figs, lavender oil, cedar wood, lotus flowers, chamomile flowers, ylang ylang, ginkgo, pine needle, cypress, oranges, Rosewood, plum birch leaf extract, aloe vera extract, marigold, hibiscus, burdock root witch hazel, aquatic forage, algae, quince, water lily, cinnamon extract, thyme, mint, lime, orange, grapefruit extracts , Mandarin, juniper, valerian, lemon balm, eucalyptus, thyme, palmarosa, cinnamon, rosemary, rosewood, lemongrass, wild rose, spruce needle, pine needle, ginger, currant, lime blossom, marigold, magnolia, pineapple, guava, Echinacea, Ivy Leaf Extract Blueberry, Kaki-, Melon- Extract u. Ä., or mixtures thereof.

These extracts are prepared in known manner such as. B. produced by steam distillation. As a result z. B. essential oils obtained from the said plants, which are particularly preferred. The extracts can also z. B. by solvent extraction (with alcohols, triglycerides or hydrocarbons, water, mixtures thereof) and used as such.

Examples of analogously synthesized substances are terpenes and terpenoids, such as camphor, menthol, cineol or mixtures thereof.

Suitable care substances are z. As essential unsaturated fatty acids and their esters, eg. As linoleic or linolenic acid, glyceryl linoleates, glyceryl linolenates.

Another group of care agents are humectants such as glycerol, propylene glycol or polyethylene glycols, polypropylene glycol, butylene glycol, sorbitol or polymers, eg. As polyquaternium types, collagen or its hydrolysates, amino acids.

Among the circulation-promoting substances include (if necessary, in addition to the above-mentioned essential oils / extracts) z. As nicotinic acid derivatives such as methyl or tocopheryl nicotinate, alpha- and betahydroxy acids and their derivatives, for. As glycolic, malic, citric, tartaric, lactic acid, salicylic acid, isopropylbenzyl salicylates, C12-13 alkyl lactates (Cosmacol ^® ELI) or antiphlogistic and antibacterial substances such as triterpenes, such as ursolic acid, glycyrrhizinic or glycyrrhetinic acid and their derivatives, eg Stearyl glycyrrhetinates, potassium glycyrrhinate; Pantothenic acid derivatives, e.g. As D-panthenol, panthenyl triacetate or polyphenols, flavonoids, z. B. rutin, ferulic acid and their esters or isoflavones such as soy isoflavones or coenzyme Q 10. As a hygienic / dermatological-medical agents are suitable, for. As dexpanthenol, allantoin, bisabolol and minerals and trace elements such as copper, zinc, or their derivatives such as Zincidone ^® (zinc PCA-pyrrolidonecarboxylic acid), zinc gluconate or copper gluconate.

Another group of suitable additional active ingredients are vitamins or derivatives thereof. Here, both more water-soluble and more fat-soluble substances come into consideration. Depending on the preparation, solid or liquid or derivatives can be used. The water-soluble representatives include in particular: vitamin C or suitable derivatives thereof such as - palmitate, calcium ascorbate / sodium ascorbate, potassium ascorbate, furthermore the vitamins of the B group such as B1 (thiamine, eg thiamine nitrate), B2 (riboflavin as), B3 (niacin, nicotinic acid and derivatives thereof such as niacinamide), B5 (pantothenic acid) such as calcium pantothenate or provitmain B5; B6 (pyridoxine or pyridoxine hydrochloride or phosphate), B7 (vitamin H, biotin, B9 (folic acid), B12 (cobalamin) or carotenoids such as beta / alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin, lycopene fat-soluble vitamins include, in particular, vitamin E (tocopherol and derivatives thereof such as tocopheryl acetate, tocopheryl palmitate, tocopheryl succinate), furthermore vitamin A (retinol) and derivatives such as retinyl palmitate, retinyl acetate, retinyl-pro-prionate, vitamin D (cholecalciferol, ergocalciferol) or vitamin K ( phylloquinone).

Particular preference is given to combining vitamin C, in particular palmitate or calcium ascorbate, and / or vitamin E (in particular acetate, succinate) and / or vitamin B5 and / or vitamin B7. Another suitable vitamin combination in probiotic preparations according to the invention comprises vitamin A, in particular the palmitate, vitamin E acetate, beta-carotene, folic acid and / or vitamin B5. Also, vitamin C, z. For example, vitamin C palmitate may be combined with niacinamide, provitamin B5 or pantothenic acid.

The individual vitamins or derivatives thereof are used in the appropriate amounts between 0.5 and 3% each, in total in an amount of 1 to 7 wt.%, Based on the total weight of the preparation.

Preferred additional active ingredients are selected from essential oils, plant extracts, vitamins, care substances or mixtures thereof.

dosage forms

Are flowable, especially liquid products desired, such. For example, those for a full bath, an arm bath, a foot bath, shower, preferably lipid baths or lipid showers, etc. preferably oil baths / oil showers (water content in particular less than 1 wt.%), Which produces a lipid base of 25 bis 90, especially 40 to 85% by weight of lipid; 5 to 25% by weight, in particular 5-15% by weight, of dispersant; 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ , germs / g Preparation Probiotic microorganisms selected from bacteria of the genus Lactobacillus, Bifidus or mixtures thereof, and the remainder suitable additives / additives have. As additives, especially dyes, perfumes, consistency regulators come into question here. Such preparations are fluid to liquid, preferably low viscous.

Particularly suitable preparations are those which contain 45% to 82% by weight of lipid component (s) (especially natural liquid oils as described); 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ germs / g Preparation Probiotic microorganisms; From 5 to 25% by weight, before oylated nonionic dispersants; 0.1 to 20 wt.% Additives, optionally 0, or 0.3 to 10 wt.% Additional active ingredients. Also particularly suitable are preparations which contain 50 to 70% by weight of one or more of the mentioned lipid components; and from 5 to 20% by weight, in particular from 10 to 20% by weight, of one or more dispersants, in particular nonionic agents as mentioned above; 10 ² to 10 ⁹ , especially 10 ³ to 10, germs / g Preparation Probiotic microorganism, optionally 1 to 8 wt.% Additives, 0.5 to 10 wt.% Additives selected from dyes, perfumes, consistency regulators.

In a further embodiment, solid preparations in the form of a powder / granule or a tablet are obtained from preferably 60-80% by weight of mineral salts, or 0 to 40% of mineral salts and 80 to 40% effervescent salt, and 0.1 to 20, in particular up to 10 wt.% Additives, preferably selected from perfumes, dyes, consistency agents, in particular consistency colloids as described above (cellulose ethers, guar gum, xanthan, poloxamer-polysiloxane copolymers, starch or starch derivatives such as rice, wheat, corn and potato starch, protein hydrolysates of plant and / or animal origin, collagen hydrolysates). Furthermore, especially 0-15 wt.%, Above all, 0.5 to 15 wt.%, In particular 1-10% wt.% Additive ingredients present, especially selected from essential oils, plant extracts, skin care substances, vitamins, and in particular 1-25% by weight, especially 2.5-20% by weight of one or more lipid components; 0.3-20% by weight, in particular 0.5-8% by weight of one or more dispersants (especially mixtures of nonionic dispersants ai) to aiv), in particular ai), aiii) and / or anionic dispersants bi), bii)); and 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ , germs / g Preparation Probiotic microorganism included. Part or all of the mineral salts may also be replaced by a carbonate / bicarbonate salt mixture as described above.

Salts of the cations sodium, potassium, magnesium, calcium, iron, ammonium or manganese and the anions bicarbonate, chloride, fluoride, sulfate or nitrate are used as such or as mixtures as mineral salts. Furthermore, other known from the Thermalbadmileu salts such. B. in the cations lithium, aluminum, strontium, and in the anions iodide, bromide, thiosulfate, are used. As a result, thermal bath analogous conditions can be achieved.

The carbonate / bicarbonate acid mixture for this purpose is known and usually consists of 5-80% carbonate / bicarbonate, preferably 10-50%, such as. As sodium or potassium (bi) carbonate or ammonium (bi) carbonate, potassium carbonate and 10-80%, preferably 10-50%, of an acid, in particular an organic acid, such as. Citric or tartaric acid or fumaric acid or adipic acid or mixtures thereof, or an acid anhydride such as citric or succinic anhydride; or inorganic acid salts such as sodium dihydrogen phosphate, sodium fumarate or mixtures thereof.

With the above-mentioned mineral salts, in particular rock salt and / or sea salt, preparations according to the invention can be used directly as powder, granules.

Particularly preferred lipid components, as they can be used in solid products of the invention such as powder / granules / tablets are, for. Hydrogenated soybean oil, hydrogenated peanut oil, in combination with natural oils as mentioned above with a total oleic acid / linoleic acid content (Σ) of at least 50% by weight.

Instead of salts and urea can be used as a solid carrier z. B. in amounts of 80 to 95 wt.% Can be used. As dispersing or lipid components, as well as additional additives, it is possible with preference to use those components mentioned above for the abovementioned solid salt dosage forms, especially the consistency colloids.

In the dosage forms described above, it is further preferred that 0.3 to 5% by weight of one or more vesicle formers be present as described, especially 0.5 to 4% by weight.

dosage forms

The preparations are in particular one-part, especially single-phase, presented and include the entire mixture, from which the user can take a suitable amount, such. B. by pouring at liquid funds. The packaging / outer packaging may contain instructions for the respective application quantity. Possibly. It may be advantageous to provide a smaller individual package with a suitable pre-dosed amount of preparation such as. B. smaller single container for travel, single use. This can be especially advantageous for solid products such as bath salt granules or bath salt tablets. These can then be easily applied as a single dose.

manufacturing

The preparations according to the invention are prepared in conventional apparatus (stainless steel kettle with stirrer / mixer) at room temperature. These are z. B. presented in a stainless steel container, the liquid lipids. Solid lipids, if present, are liquefied in a separate vessel by suitable means (eg heating) and added to the liquid lipids with stirring. The addition of dispersants, if necessary vesicle formers, additives or additional active ingredients, perfume oils is then followed successively with stirring. The probiotic germs are finally suspended as a powder in the mixture. It will not filtered. The packaging follows directly on the production and takes place with stirring. Depending on the type of packaging, z. As oil bath or shower bath, footbath, powder, tablet suitable additives, active ingredients may be added, which are used for this purpose or purposefully as described above. Appropriately, the finished products are sealed.

For the preparation of a solid dosage form such. B. powder / granules or tablets (eg., 10-300 g weight), the solid support materials are placed in a suitable mixer and with about half of the previously separately prepared liquid solution of lipids, if necessary Vesikelbildnern, dispersants, possibly perfumes , Wets additive (eg by application, sprinkling or spraying). The addition of further solid constituents, if present, such as additives, additional active ingredients, effervescent salt, then takes place with mixing. At the end, the probiotic ingredients are added. Possibly. additional liquid solution is added by application, sprinkling or spraying and mixed. If desired, granulation / tableting and then packaging can be added to the powder production. The entire production takes place at room temperature.

application

The preparations described can be used both in the tub and in the shower (here liquid preparations) for partial or full baths for primarily cosmetic, or dermatological or medical purposes. The appropriate amount is used by the user, generally according to an amount indicated on the package containing the preparation. Depending on the secondary use such as refreshment, thermal bath, relaxation bath / shower, foot bath, medical bath (cold, rheumatism, etc.) / shower may contain appropriate additives. In addition to the resulting effect due to the special combination of raw materials an improved skin effect by the effected microbial preservation.

The duration of the application depends on the respective z. B. secondary target, such. B. 5 to 30 minutes bath tub / foot bath, a few minutes shower. In the tub, the temperature of the water should be between 33 ° C and 42 ° C, as well as in the shower or foot bath. The preparations are designed in such a way that no special measures to remove any residues are to be taken after the application has been completed. Rinsing with water and / or wiping, if desired, but can be done.

Examples

The invention will be explained in more detail with reference to the following examples, which are merely illustrative but not restrictive. The quantities are based on the total weight in%, unless stated otherwise. Example 1: Probiotic preparation (liquid oil bath / oil shower) INCI name / product name Wt.% soybean oil 67,00 Rosehip seed oil 5.00 Macademianussöl 2.00 Laureth 3 20.00 soy lecithin 2.00 Bifidobacterium BB-12 (30 x 10 ⁹ germs / g powder 1.00 Perfume 2.00 tocopherol 1.00 total 100.00 Example 2 Probiotic liquid oil bath (liquid) INCI name / product name Wt.% olive oil 81.50 Laureth 3 10.00 soy lecithin 2.00 Bifidobacterium BB-12 (30 x 10 ⁹ germs / g powder 1.00 panthenol 2.00 tocopherol 1.00 Perfume 2.50 total 100.00 Example 3 Probiotic liquid oil bath INCI name / product name Wt.% almond oil 84.50 Laureth-3 10.00 Bifidobacterium BB-12 (30 x 10 ⁹ germs / g powder 1.00 Perfume 2.50 panthenol 2.00 total 100.00 Example 4 Probiotic liquid oil bath INCI name / product name Wt.% Grapeseed oil 18.50 soybean oil 58,00 sesame oil 3.00 Shea butter 2.00 Laureth 4 10.00 Lactobacillus acidophilus LA-5 (30x10 ⁹ germs / g powder 1.00 egg lecithin 4.00 Perfume 3.00 tocopherol 0.50 total 100.00 Example 5 Probiotic solid preparation (bath salt) INCI name / product name Wt.% sodium chloride 82.04 Magnolia extract 1.00 Laureth-3 1.00 Sodium methyl oleyl taurate 3.00 Bifidobacterium BB-12 (30 x 10 ⁹ germs / g powder 0.35 Hydrogenated sunflower seed oil 0.50 Hydrogenated palm oil 0.50 coconut oil 2.00 Soy lecithin, solid 2.00 Perfume 2.00 tocopherol 0.50 magnesium carbonate 5.00 Dye Cochenillerot 0.10 Dye yellow-orange 0.01 total 100.00 Example 6 Probiotic solid preparation (bath salt) INCI name / product name Wt.% sodium chloride 89.93 Laureth-3 3.00 Bifidobacterium BB-12 (30 × 10 ⁹ cells / g powder 0.35 Grapeseed oil 1.00 Hydrogenated palm oil 1.00 Soy lecithin, liquid 2.00 magnesium carbonate 2.50 Dye patent blue 0.02 Dye quinoline yellow 0.20 total 100.00 Example 7 Probiotic solid preparation (bath salt) INCI name / product name Wt.% sodium chloride 92,00 Laureth-3 3.00 Bifodobacterium BB-12 (30x10 ⁹ germs / g powder) 0.35 Hydrogenated sunflower seed oil 1.00 Palm kernel oil 1.00 magnesium carbonate 2.50 Dye patent blue 0.02 Dye Cochenillerot 0.13 total 100.00 Example 8 Probiotic solid preparation (bath salt) INCI name / product name Wt.% sodium chloride 81,95 Fig extract 1.00 Laureth-3 1.00 Sodium lauryl ether sulfate 3.00 Lactobacillus acidophilus (30 x 10 ⁹ germs / g powder) 0.35 Apricot kernel oil 1.50 almond oil 2.00 soy lecithin 2.00 Perfume 2.00 magnesium carbonate 5.00 Dye Cochenillerot 0.20 total 100.00

Example 9

Detection of lactic acid bacteria on the skin after bathing with probiotic bath additives according to the invention

Test Preparation:

By means of a plastic template, an area of 100 cm ^{2 was} marked on the inside of the forearm of the test subjects, which is immersed in the bathing liquor.

Used germ

• Bifido LA-5 powder (about 30 × 10 ⁹ seeds per gram of powder).

Concentration in test preparations:

• 1. Liquid probiotics oil bath: 1 g Bifidobacterium powder as described above in 100 g oil bath preparation gives 1 × 10 ⁹ germs per 10 l bath water analogous to a normal application dosage of 30 g preparation / 100 l bath water.
• 2. Solid probiotics bath salt: 0.2 g Bifidobacterium powder as described in 60 g solid salt preparation = 6 × 10 ⁹ germs / 60 g bath salt preparation results in the tub a concentration of 2 × 10 ⁹ germs / 10 l bath water.

Test procedure:

Plastic trays with 10 L water content are used. The exactly weighed amount of bath preparation (solid / liquid) for 10 L bath water is added to the incoming bath water. The water temperature is approx. 37 ° C to 39 ° C. The duration of the bracelet is 5 minutes. During bathing, the arm is easily moved in the tub. After bathing and drying the skin in the air, a skin sample of the entire previously marked area of 100 cm ² is removed by stripping the skin and analyzed microbiologically using a suitable test stick.

The results are summarized in Table 1 below: TABLE 1 Skin smear of dry skin (See 1) no detection of lactic acid bacteria Skin smear of skin after bathing in water without additives (See 2) no detection of lactic acid bacteria Skin smear after bathing in liquid preparation according to Ex. 3 (Erf.) 9 × 10 ² cfu / swab Skin smear after bathing in liquid preparation according to Ex. 2 (Erf.) 7.2 × 10 ³ cfu / swab Skin swab after bathing in liquid preparation according to Ex. 1 (Erf.) 3 × 10 ⁴ cfu / swab Skin swab after bathing in bath salt according to Ex. 7 3.5 × 10 ² cfu / swab Skin swab after bathing in bath salts according to Ex. 6 1.0 × 10 ⁴ cfu / swab Skin swab after bathing in bath salts according to Ex. 5 4 × 10 ⁴ cfu / swab

Example 10 Stability Proofs

Test samples according to the preparations of Example 3 or Example 5 were tested according to standard tests (SOP) according to standard laboratory methods for their stabilities. The results are summarized in Table 2a, b. Table 2a: Example 3 Bacteria concentration / time of measurement of the test sample start value 3 months concentration 2.8 × 10 ⁸ per g 1.9 × 10 ⁸ per g examined on: 30/08/2010 12/13/2010 Table 2b: Example 5 Bacteria concentration / time of measurement of the test sample start value 3 months concentration 4 × 10 ⁷ per g Sachet: 7.6 x 10 ⁶ per g Glass bottle, fumigated: 1.3 × 10 ⁷ per g Screw vessel: (with desiccant) 2.1 × 10 ⁷ per g examined on: 30/08/2010 12/13/2010

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• EP 1629846 A2 [0003]
• DE 69832267 T4 [0003]
• DE 69634171 T4 [0004]
• EP 0131114 B1 [0004]
• US 2008/0107699 [0004]
• DE 69832267 T2 [0004, 0004]

Cited non-patent literature

• DAZ, 150th year, 02.09.2010, No. 35, pages 3925-3934 [0021]

Claims (13)

Flowable or solid balneological preparation having substantially anhydrous (less than 1% by weight) liquid lipid base or a substantially anhydrous solid lipid-containing base based on a carrier selected from mineral salts, effervescent salts, urea, characterized in that the spreading comprises one or more lipid components, and one or more dispersants selected from nonionic and anionic dispergents or mixtures thereof, and 10 ² to 10 ⁹ germs / g preparation Probiotic microorganism selected from lactobacilli, Bifidobacteria or mixtures thereof, wherein the lipid component (s) is selected from a or more natural liquid oils having a total content of oleic and linoleic acids of at least 50% by weight, hydrogenated derivatives thereof and mixtures of these lipid components. A preparation according to claim 1, characterized in that it further comprises 0.1 to 20 wt.% Additives selected from consistency agents, dyes and perfumes or mixtures thereof; and / or 0.1 to 15% by weight. Add active ingredients and less than 1% water. Preparation according to claim 1 or 2, characterized in that it further comprises one or more vesicle-forming agents, preferably in an amount of 0.1 to 5 wt.%, Selected from lecithins, phospholipids, sphingosines, cerebrosides, ceramides or mixtures thereof. Preparation according to one of claims 1 to 3, characterized in that the lipid component (s) is / are selected from one or more lipids of the group comprising apricot kernel oil, avocado oil, borage seed oil, thistle oil, peanut oil, hazelnut oil, pumpkin seed oil, corn oil, almond oil, Marula oil, macademia nut oil, poppy seed oil, evening primrose oil, olive oil, palm oil, pine nut oil, rice germ oil, sea buckthorn oil, sesame oil, soybean oil, sunflower oil, grapeseed oil, walnut oil, wheat germ oil; hydrogenated derivatives of these oils such as peanut oil, olive oil, palm oil, sunflower oil, soybean oil (each hydrogenated) or mixtures thereof. Composition according to any one of Claims 1 to 4, characterized in that the dispersant or dispersants are chosen from: a) nonionic dispersants of the group comprising: ai) (W / O) agents having an HLB value of 7-11 of cetearyl alcohol, glycerol stearate; low-polyethoxylated or -propoxylated or else mixed low- _polyoxylated C _{8-22 fatty} alcohols having a degree of ethoxylation and / or degree of propoxylation (EO / PO degree) of 1-5 EO; aii) oil-soluble, water-dispersible polyoxyethylated C _8-22 fatty alcohols / fatty acids having an HLB value of 7.5 to 12, preferably 7.5 to 10 and an EO degree of 1-15; aiii) (O / W) agent having an HLB of 13-25 selected from higher polyoxyethylated / and / or propoxylated C _8-22 fatty alcohols; ethoxylated and / or propoxylated C _12-22 fatty acids having ethoxylation or propoxylation levels of 8-25; aiv) sugar esters or sugar esters of C _12-22 fatty acids or C _8-22 fatty alcohols; polyoxyethylated and / or polyoxypropylated sugar esters of C ₁₂ -C ₁₈ fatty acids, wherein the EO or PO degree is 8-25; or mixtures thereof; b) anionic compounds of the group comprising: bi) C _8-22 alkyl sulfates, C _8-22 alkyl _ether sulfates or their alkali _metal salts, especially sodium salts or oxylated derivatives having a degree of ethoxylation and / or degree of propoxylation (EO / PO degree) of 1 6 EO; bii) (alkyl) -C ₁₂ -C ₂₂ fatty alcohol amino acid ester compounds, in particular an alkali metal salt thereof, wherein the amino acids are selected from glycine, taurine, or mixtures thereof; or c) mixtures of one or more representatives of group a) and one or more representatives of group b). Preparation according to one of claims 1 to 5, characterized in that it is in liquid form and 40 to 90 wt.% Of one or more lipids, in particular selected from natural liquid oils with a total content of oleic and linoleic acid of at least Σ 50 wt. %; 1 to 30% by weight of one or more dispersing agents, in particular selected from the group a); 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ , germs / g Preparation Probiotic microorganism; 0.1 to 20% by weight of additives and / or 0.1 to 15% by weight. Having additional active ingredients. Preparation according to one of claims 1 to 5, characterized in that it is in the form of a solid powder / granules or a tablet of 60-80 wt.% Mineral salt or 0 to 40% mineral salt and 80 to 40% effervescent salt, and further 1- 25% by weight of lipid component (s), in particular selected from one or more natural liquid oils having a total content of oleic and linoleic acids of at least Σ 50 % By weight in combination with one or more hydrogenated derivatives thereof; 0.5-8% by weight of one or more dispersants, especially selected from one or more agents of group a) in combination with one or more agents of group b); 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ , germs / g preparation Probiotioscher microorganism and 0.5 to 15 wt.% Additive ingredients and 0.1 to 20% additives. Composition according to any one of Claims 1 to 5, characterized in that it is in solid form and contains 80 to 95% urea, 2.5-25% by weight of lipid component (s), in particular selected from one or more natural liquid oils having a total content of oleic and linoleic acids of at least 50% by weight in combination with one or more hydrogenated derivatives thereof; 0.5-8% by weight of one or more dispersants, especially selected from one or more agents of group a) in combination with one or more agents of group b); 10 ² to 10 ⁹ , especially 10 ³ to 10 ⁷ , germs / g preparation Probiotioscher microorganism and 0.5 to 15 wt.% Additive ingredients and 0.1 to 20% additives. Preparation according to one of claims 5 to 8, characterized in that it further comprises 0.5 to 4 wt.% Of one or more Vesikelbildner. Preparation according to one of claims 1 to 9, characterized in that the Probiotioscher microorganism is selected from those of the genus Lactobacillus or Bifidobacterium. Preparation according to one of claims 1 to 10, characterized in that it comprises one or more additional active ingredients selected from essential oils, plant extracts, circulation-promoting substances, vitamins, skin care agents or mixtures thereof. Cosmetic, dermatological or medical use of a preparation according to one of claims 1 to 11 as an additive for full or partial baths, for the bath, shower or foot bath. Use according to claim 12 as an oil bath, foot bath, bath powder, ready-to-use bath powder, ready-made additive as a single-use pack or as a multiple-dose pack.