DE102009043803B4 - Injection device with a discharge stop function - Google Patents

Abstract

A delivery device for administering a liquid product, comprising: a) a housing (1), b) a product container having a piston slidably disposed therein in the dispensing direction, c) a dose indicator member (2) rotationally and translationally interposed relative to the housing (1) d) a control knob (5) formed at the proximal end of the administering device and operable for product dispensing, wherein a driving force applied to the operating knob (5) is transmitted via a drive train (5, 3, 6, 7, 8) is transferable to the piston, whereby the piston is movable in the discharge direction, characterized by e) a device (9) which directs the drive force from the drive train (5, 3, 6, 7, 8), before the dose indicator (2) is in its distal end position.

Description

The invention relates to a device for administering a liquid product, in particular a medicament. Such a device, the z. B. may also be referred to as an injection or administration device, z. As used in insulin therapy in diabetics, but is not necessarily limited thereto. The device is equipped with a device that allows the administration of only a certain predetermined amount of product.

From the WO 2006/077466 A2 For example, an injection device is known in which a product container with a piston displaceable therein contains a certain predetermined amount of product. This predetermined amount of product can be distributed gradually with several adjustable product doses. In the case of the device known from the prior art, it may be the case that the dosing button is used to set a dose which is greater than a residue in the product container which has been left over at several previous dose distributions. In this situation, when the product dispensing device is actuated, before the dose indicating drum reaches zero, the piston is pressed against the front end of the product container. Does the user of the device a more or less strong pressure on the actuator, z. B. due to the elasticity of the piston more or less of the large deviation between the set dose, the dose actually administered and the amount contained in the product container occur. This can have unpleasant and even dangerous consequences for the user of the device.

In the DE 10 2008 011 881 A1 a braking device for an injection device for generating a braking effect on a moving or rotating part of the injection device is disclosed. The energy for the product distribution is provided by a preloaded spring which can displace a piston rod acting on a piston in the discharge direction. By pressing an operating button, the energy stored in the spring is released.

From the WO 99/38554 and the EP 0 327 910 A2 For example, pen-shaped injection devices are known in which the user of the device presses a product dispensing button formed on the proximal end of the delivery device. The force exerted on the actuating button driving force is transmitted over several parts to the piston, whereby this is moved in the discharge direction.

From the DE 200 23 735 U1 For example, a limiting mechanism is known which prevents the setting of a dose which exceeds the amount of liquid remaining in the product container. The mechanism may, for. B. in the device from the 15 to 17 of the WO 99/38554 Find application.

It is an object of the invention to provide an injection device which overcomes the disadvantages of the known from the prior art injection device, in particular prevents incorrect dosing.

The object is solved with the features of claim 1. Preferred embodiments result from the dependent claims and the description.

The invention relates to an administration device of the type mentioned. For example, the administration device from the WO 2006/077466 A2 Starting point for the device according to the invention.

The device according to the invention comprises a housing, which may be mono- or preferably multi-part design. The housing may be designed so that the device is substantially cylindrical, which is why it is referred to in the art as so-called Injektionspen. The housing may include a product container holder, which may be referred to as a carpule holder when used with a carpule, a mechanism holder and a rear housing part. The carpule holder preferably connects distally to the rear housing part. The rear housing part may surround the mechanism holder at least partially preferably completely, in particular concentrically. In particular, an annular gap may be formed between the mechanism holder and the rear housing part by further parts of the device, such as. B. a dose display drum and / or a coupling member can be added. The housing, in particular the parts of the housing may each be sleeve-shaped.

The device further comprises a product container with a piston displaceably arranged therein in the dispensing direction. Such a product container may, for. B. a syringe or preferably a carpule. By displacement of the piston, the product contained in the product container can be expelled or displaced via an opening or needle formed at the distal end of the container. Such product containers are well known from the prior art and a person skilled in the art. Preferably, the product container may be a standard carpule, the z. B. 300 international units (IU) of a drug, such as. B. one Insulin, contains. The product container may, for example, be permanently installed in the administering device, ie the product container can not be removed from the device without destroying the administering device. The device is thrown away after emptying the product container together with this. Preferably, the device is shipped with inserted product container. Alternatively, the device may also be a reusable device in which the product container can be replaced after emptying against a filled product container without destroying the administering device. The device is then a reusable device. The product container is accommodated in the product container holder.

The device further comprises a dose indicator member which is rotationally and translationally relative to the housing, in particular with a combined rotational and translational movement, such. B. a screwing movement, between a distal end position and a proximal end position movable, for example, is movable back and forth. For dose adjustment, the dose indicator can be unscrewed (dose increase) from the rear end of the device or screwed into the rear end of the device (dose reduction). For this purpose, the dose indicator member, which may be configured as dose display sleeve or drum, be provided at its outer periphery or alternatively at its inner periphery with a thread, with which it is inserted into the housing, such as. B. can engage in the rear housing part or alternatively in the mechanism holder. At the dose indicator member, a preferably helically encircling dose scale can be arranged, which can be read by a reading range formed on the housing. The dose scale can, for example, circulate several times around the circumference of the dose indicator. The helically encircling dose scale can, for. B. have the same pitch as the thread with which the dose indicator member engages the housing. A single value of the dose scale can be read through the reading area, which may be, for example, an opening or a window filled with a transparent material. Preferably, the dose scale of 0 to 60, 80 or 100 IU, each divided into discrete steps, such. B. be divided into one or two steps. The highest value of the dose scale can be called maximum value and corresponds to the maximum dose.

With the device, a dose can be set that ranges between 0 and the maximum value indicated on the dose display drum. In particular, regardless of the level of the product container at the dose display drum always the maximum value can be set. This means that even then the maximum value can be set if the amount of product contained in the product container is smaller than the maximum value indicated on the dose scale.

The dose indicator member may have a stopper which, in its zero dose position, in which the value 0 is displayed, gets into abutment with the housing. Furthermore, the dose indicator member may have a stopper, with which it comes in a stop with the housing in its maximum dose position, in which the highest value of the dose scale is displayed. The one or more stops formed on the housing are equal to stops on a fixedly connected to the housing element. The zero dose position and maximum dose position stops may form the distal (zero dose position) and proximal (maximum dose position) end positions of the dose indicator. The stops can as axial stops, d. H. in the longitudinal direction of the device acting stops, or as rotation stops, d. H. in the circumferential direction of the device acting stops. The stop for the zero dose position prevents rotation of the dose indicator in a direction of rotation, in particular "below zero". The stop for the maximum dose position prevents rotation in the other direction of rotation, in particular beyond the maximum dose.

For dose adjustment, the dose indicator may be reciprocable between the distal and proximal end positions. For dose distribution, the dose indicator is preferably moved to the distal end position.

The administering device has an actuating device which can be actuated for product dispensing and from which a driving force can be transmitted via a drive train to the piston, whereby the piston can be moved in the dispensing direction. The actuator may, for. B. be an operating knob in the rear, d. H. is formed at the proximal end of the injection device. The force exerted on the button is transmitted to the piston via the drive train in an over- or underdriven manner. The piston is not part of the powertrain. For example, the force exerted on the actuator axial movement in the drive train can be converted into a rotational movement, said rotational movement is converted back into an axial movement in particular at the part which presses against the piston. The drive train z. As the operation button, a coupling member, a drive member and an output member, optionally also the dose indicator are assigned. This list may or may not be exhaustive. For example, a stop element may optionally also belong to the drive train.

Preferably, upon actuation of the actuator, the dose indicator is reset in the direction of the zero position.

In accordance with the invention, the delivery device comprises means for directing the drive force from the drive train before the dose indicator is in its distal end position. Under a driving force is also a z. B. understood by converting the force exerted on the actuator force generated moment, since it is a moment multiplied by a force with a lever arm. In principle, the device can be designed on any of the above-mentioned parts of the drive train. Preferably, the device is designed so that the driving force, in particular directly, is discharged into the housing. The advantage of this device is that despite the exertion of an increased pressure on the actuator by the user of the device, the piston usually formed of an elastic material is not compressed or pressed against the front end of the product container. As a result, incorrect dosages can be avoided, the z. B. caused by the elasticity of the piston or parts contained in the drive train and games. In particular, with this device manufacturer certain residual quantities can be realized in the product container, which are greater than or equal to an IE, when the driving force is passed from the drive train. For example, there may be a clearance between the distal end of the piston and the distal end of the product container to which the piston would normally impact. This distance may correspond to one or more IE, preferably a few IE. Should such a distance not be provided, it can at least be prevented with the device according to the invention that the piston is pressed against the distal end of the interior of the product container.

Advantageously, the difference between the last dose set before distribution and the actually distributed dose is readable via the display area on the dose scale in the position in which the device directs the drive force from the drive train. This allows the user of the device in a new, ie filled administration device, set the displayed difference value of the emptied device and thus inject the outstanding amount of product without having to perform a calculation step, he z. B. in the device of the WO 2004/078240 A2 must perform. Generally preferred, the device can ensure that a value is read on the dose display, which is greater than the minimum value plotted on the dose scale, such. B. is zero, when the device directs the drive power from the drive train. Also, this can be limited by the manufacturer from the dispensable from the product container dosage amount by the non-distributable residual amount is increased in the product container, which is more cost-effective, for example, relatively inexpensive drugs than to develop and allow for a smaller amount of product product container.

Particularly preferably, the administering device comprises a driven member, which presses against the piston during dispensing. The adjoining the piston end of the output member may, for. B. a broadening, such as. B. have a flange. In particular, the output member may be a hollow piston rod. The administering device may also comprise a drive member which is in such an engagement with the driven member, in particular a threaded engagement or a Kurvengetriebeeingriff that the driven member during rotation of the drive member performs an axial movement in the discharge direction. The output member may form a passage for at least a portion of the drive member. For example, the output member may be sleeve-shaped. The drive member may be or include a drive rod. The drive rod may be received, for example, within the hollow output member.

The drive member may be in one piece or preferably in several parts. In a multi-part drive member whose parts z. B. axially and rotationally connected to each other, in particular be locked or welded. For example, the drive member may comprise the drive rod and a drive sleeve surrounding the drive rod, wherein drive rod and drive sleeve are positively connected, alternatively integrally connected to each other. The drive sleeve may also surround the output member. For example, between the drive rod and the drive sleeve in particular an annular groove may be formed, in which at least the output member may be arranged.

Preferably, the drive member is rotatable and axially fixed relative to the housing, in particular connected to the housing. The output member is preferably non-rotatable and axially movable, in particular relative to the housing. The output member may, for. B. with longitudinal grooves on a housing part, such as. B. be guided to the mechanism holder. For example, the mechanism holder may surround the output member. About z. As the threaded engagement, the rotational movement of the drive member can be converted into an axial movement of the output member. The housing, in particular the mechanism holder of the housing may have longitudinal grooves for the longitudinal guide and the rotation of the output member. The mechanism holder may surround the output member, in particular sleeve-shaped, wherein expediently on the inner circumference of the mechanism holder the Longitudinal guide for correspondingly arranged on the outside of the driven member counter elements are arranged.

Preferably, the pitch of the threaded engagement between the output member and the drive member is smaller than the pitch of the threaded engagement between the dose indicating member and the housing, particularly the rear housing portion. This can be advantageous to generate a translation, d. H. that the distance traveled by the dose-indicating element during actuation of the device is greater than the distance traveled by the output element. As a result, the driving force is increased until it arrives at the piston, preferably on the way through the drive train.

As an example of the device which can guide the driving force from the drive train, the term diversion device is understood below, which, however, need not necessarily be regarded as limiting. The diversion device can alternatively also be referred to as a stop element. In particular, the diversion device can engage in two mutually different grooves. A groove may be a first thread. The other groove may be a longitudinal guide or a second thread. The second thread may have a different pitch than the first thread. Preferably, the grooves are arranged on parts of the administering device which perform no rotational movement relative to each other during the dose setting and during the dose distribution. For example, one part may be a drive member and the other part may be the housing. Preferably, the diversion device engages in the housing, in particular in the rear housing part or the mechanism holder, on the one hand and in the drive member on the other hand.

In preferred embodiments, the diverter may be a ball, a ring or a segment of the ring. The ring may have at least the first thread and the longitudinal guide or the second thread. The first thread may be an internal thread or an external thread, wherein preferably the second thread is an external thread (in a first thread as an internal thread) or an internal thread (in a first thread as an external thread). Instead of the second thread, the longitudinal guide can be arranged correspondingly on the outside or on the inside of the ring. A longitudinal guide is understood to mean a rotationally fixed and longitudinally displaceable guide. In preferred embodiments, at the dose setting, the drive member relative to the housing, in particular to the mechanism holder or the rear housing part, rotationally fixed and rotatable at a dose distribution relative to the housing. It is preferably effected that during the dose adjustment, the diverting element rests relative to the housing and in the case of the dose distribution the diverting element rotates and / or moves axially relative to the housing.

In a preferred embodiment, the diverting element engages in an external thread of the mechanism holder of the housing and a longitudinal guide of the drive member.

In an alternative embodiment, the diverting element can engage in an internal thread of the rear housing part and in a longitudinal guide of the drive member.

In a further alternative, the diverting element may be formed on the output member, for. B. in the form of a Abragung that can strike a corresponding stop of the housing.

It is generally preferred that the diverting element has an abutment surface that abuts a counter-abutment surface axially or circumferentially before the dose-indicating element is in its distal end position. In particular, the counter-abutment surface may be formed on or from the housing. The counter-attack surface can, for. B. may be formed on a projection formed by the housing, which is either fixed or resiliently arranged on the housing. A resilient arrangement can, for. B. offer advantages during assembly.

Generally, preferably, the delivery device comprises a rotatable metering device kinematically coupled to the dose indicating member. Under kinematically coupled a connection is passed, which can cause an interaction between the coupled members. When the metering device is rotated, the dose-indicating element can preferably perform the combined translatory-rotational movement relative to the housing. For this purpose, z. B. the dose indicator be axially and rotatably connected to the metering device. Alternatively, the metering device can be rotatable and axially fixed relative to the housing, wherein z. B. the dose indicator is coupled with a longitudinal guide with the metering device, so that it participates in the rotational movement of the metering device and can move axially relative to the metering device. Generally, a rotationally fixed coupling between metering device and dose indicator is preferred. In particular, the metering device can be referred to as dose setting button, the z. B. the user can engage around the dose setting and twist.

In preferred embodiments, a coupling can be arranged kinematically between a coupling member and the dose indicator element, with which the coupling member and the dose indicator member can be non-rotatably coupled for product dispensing. The coupling can be for a Dose setting be decoupled so that between the coupling member and dose indicator a rotational relative movement can take place. Preferably, the coupling member is rotatably and axially slidably connected to the drive member. This causes that upon actuation of the actuator for the dose indicator performs a rotational movement, wherein the coupling member participates via the coupled coupling this rotational movement, whereby the non-rotatably connected to the coupling member drive member performs a rotational movement. About the thread that couples the output member and the drive member, the rotational movement is generated in a longitudinal movement of the output member in the discharge direction. The coupling member is preferably sleeve-shaped and may at least partially surround the drive member. Preferably, the coupling is arranged on the outer circumference of the dose setting member. The dose indicating member may preferably surround the coupling member.

Preferably, the administering device may kinematically have, between the drive member and the housing, a coupling configured to allow rotational movement of the drive member in only one direction of rotation. Such clutches are also referred to as reverse lock or ratchet. This can be prevented that the drive member turns back, z. B. if after the product discharge the force exerted on the actuator force is removed.

The invention has been described with reference to several preferred embodiments. In the following preferred embodiments of the invention will be described with reference to figures, which further develop the object of the invention alone or in combination with the above-mentioned embodiments. Show it:

1a to 1c various views of an administration device according to a first embodiment,

2a to 2c different views of an administration device according to a second embodiment,

3a to 3c various views of an administering device according to a third embodiment and

4a to 4c various views of an administration device according to a fourth embodiment.

The functioning of in 1a to 4c shown administration devices is basically the same. Therefore, the invention will be initially based on 1a to 1c and subsequently to the differences in the individual devices according to the 2a to 4c received.

The administering device of the 1a to 1c has a housing 1 on, which is formed in several parts in this example, namely a product container holder 1a , a mechanic holder 1b and a rear housing part 1c includes. Both the rear housing part 1c as well as the mechanic holder 1b are each sleeve-shaped and arranged concentrically with each other, so that between the rear housing part 1c and the mechanics holder 1b an annular gap is formed. The product container with the piston arranged therein is not shown, but known to those skilled in the art under the name carpule or ampoule. The mechanics holder 1b has at its inner circumference longitudinal grooves, which are used as a longitudinal guide for the trained as a hollow piston rod output member 8th are designed. The output member 8th is relative to the mechanics holder 1b non-rotatable and axially displaceable. The output member 8th has at its inner periphery a threaded member which fits into a corresponding thread on the outer periphery of a drive rod 7 intervenes. The drive rod 7 is part of a drive link 6 . 7 further comprising a drive sleeve 6 has, with the drive rod 7 rotatably and axially connected, in particular snapped. The drive link 6 . 7 , in particular the drive rod 7 is relative to the housing 1 rotatable and on the housing 1 stored in particular axially fixed. For this purpose, a ring-shaped inwardly projecting shoulder to the mechanism holder 1b provided axially between the drive sleeve 6 and the drive rod 7 is enclosed. A rotation of the drive member 6 . 7 causes an axial movement of the output member 8th , Between the mechanics holder 1b and the drive member 6 . 7 is a ratchet acting in one direction of rotation 1d arranged, which is a rotational movement of the drive member 6 . 7 only allowed in one direction of rotation. The rotation in the opposite direction of rotation is through the coupling 1d blocked. Thus, the output member 8th only be moved in the delivery direction.

The drive link 6 . 7 , in particular the drive sleeve 7 has at its outer periphery a longitudinal groove which serves as a longitudinal guide for a coupling member 3 serves. The coupling member 3 is thus relative to the drive member 6 . 7 non-rotatable and axially displaceable.

The rear housing part 1c has an internal thread, which in a corresponding external thread of a dose indicator 2 intervenes. At the dose indicator 2 is arranged according to the thread pitch a helically arranged Dosisskala passing through a window (not shown) in the rear housing part 1c is readable. Between the dose indicator 2 and the coupling member 3 is a clutch 3a arranged in the shape of a dog clutch, with an axial movement of the coupling member 3 relative to the dose indicator 2 can be engaged. The dog clutch is an axially acting clutch. In the unactuated state, ie for dose adjustment is the clutch 3a disengaged and in the actuated state, ie engaged for dose distribution. The coupling 3a coupled in the closed state, the coupling member 3 and the dose indicator 2 rotatable with each other.

Rotationally and axially fixed with the dose indicator 2 is a metering device 4 latched in the shape of a dose setting button or connected in a broader sense. For dose setting, the dosing button 4 gripped and twisted by the user, causing the dose indicator drum 2 unscrewed from the rear end of the delivery device. The dose set by the rotation can be read through the window, not shown. Because the clutch 3a is disengaged, move the coupling member 3 , the drive member 6 . 7 and the output member 8th Not.

The administering device further comprises an actuating device 5 in the shape of a push button attached to the rear end of the administering device. Between pushbutton 5 and coupling member 3 is a spring 10 arranged, which has only a very slight spring force and is mainly used for game suspension and the generation of clicks. By the spring 10 become the elements of the dog clutch 3a only slightly pressed together, so that at a dose setting, the clutch is not closed, but the coupling elements rotatably slide on each other, so that a tactile or audible click is generated. Preferably, the clutch 3a equipped with so many clutch claws per circumference that the rotation angle per click corresponds to the angle of rotation, with which the individual values on the dose scale are spaced from each other.

To operate the device, the push button 5 pressed, causing the clutch 3a is closed. The on the push button 5 exerted axially acting driving force causes on the one hand a turning back of the dose indicator 2 in its distal end position and on the other hand, a displacement of the output member 8th in the direction of delivery. The driving force is via the drive train, which is at least the push button 5 , the coupling member 3 , the drive member 6 . 7 and the output member 8th includes transferred to the piston of the product container.

Without the inventive device 9 could be so firmly pressed against the distal end of the product container with a relatively large actuation force of the pistons at a set dose exceeding the residual amount contained in the product container that the dose actually administered would be what the user suspects , deviates.

Into the device of 1a to 1c is a mother according to the invention 9 installed, which has an internal thread and in a corresponding external thread of the mechanism holder 1b intervenes. The mother 9 also has Abragungen in longitudinal guides of the drive sleeve 6 intervene, causing the mother 9 relative to the drive sleeve 6 rotatable and axially displaceable. At the dose setting is the drive member 6 . 7 relative to the housing 1 rotatably, so the mother 9 rests. In the case of the dose distribution, the drive member becomes 6 . 7 relative to the housing 1 turned, so that also the mother 9 with the drive member 6 . 7 rotates. In the distribution is the mother 9 moved in the direction of a stop, in this example distal to the nut 9 is arranged and removed from the housing 1 is formed. The stop is in this example, an axially acting stop could alternatively be a rotation stop, ie a circumferentially acting stop. The mother 9 beats with its distal end on the stop of the housing 1 when the piston or the output member 8th have been moved to the desired stroke in the discharge direction. The on the operating button 5 applied actuating or driving force is then from the drive train 5 . 3 . 6 . 7 . 8th about the mother 9 in the case 1 discharged. This can ensure that even with an overly on the operating button 5 applied driving force no forward movement of the output member 8th is produced. Instead, the driving force in the form of a torque from the coupling member 3 on the drive sleeve 6 and from the drive sleeve 6 on the mother 9 transferred, with the force finally from the mother 9 in the case 1 is derived.

The position in the mother 9 on the housing 1 can also be called a stop position. In the stop position of the nut, despite pressing the button 5 the dose indicator 2 no longer be moved further in the distal direction. The dose indicator sleeve 2 is in the stop position of the nut 9 locked for a reset movement or a movement in the distal direction. Advantageously, in the stop position of the mother 9 on the dose indicator scale, read the difference between the adjusted and the distributed dose, ie the undistributed dose. The user of the device can adjust and administer the undistributed dose by means of a new device containing a filled product container without having to perform an intermediate calculation. The emptied administration device can be disposed of.

In 1a become the dose setting button 4 , the feather 10 and the operation button 5 also shown for the devices in the 1b . 2a . 2 B . 3a . 3b . 4a and 4b provided, but not shown.

In the embodiment of the 2a to 2c has the stop nut 9 an external thread, which in a corresponding internal thread of the housing 1 , in particular of the rear housing part 1c intervenes. The mother 9 also has grooves in the longitudinal guides of the drive member 6 . 7 , in particular the drive sleeve 6 intervention. The mother 9 is here also as in the first embodiment relative to the drive member 6 . 7 non-rotatable and axially displaceable. The function of the mother 9 is otherwise the same as in the first embodiment of the 1a to 1c ,

In the third embodiment ( 3a to 3c ) and the fourth embodiment ( 4a to 4c ) is the diversion device 9 instead of a nut in the form of a radially outwardly projecting Abragung 9 on the output member 8th educated. Instead of a separate part as in the first and second embodiments, the Abragung 9 in one piece with the output member 8th , The challenge 9 is at the rear, ie proximal end of the output member 8th arranged. The challenge 9 engages in a longitudinal groove of the mechanism holder 1b a, thereby canceling 9 also acts as anti-rotation.

Referring to the third embodiment of the 3a to 3c is the challenge 9 formed on a resilient arm extending in the proximal direction from the proximal end of the output member 8th extends. By this resilient arrangement of Abragung 9 the mountability of the administering device is simplified. In the state of the administering device in which the on the operating button 5 Applied driving force from the drive train 5 . 3 . 6 . 7 . 8th is discharged, is the Abragung 9 with its distal-facing surface in abutment with the housing 1 , The stop surface of the housing 1 is through the end of the groove in the the Abragung 9 engages, formed and is rigid in this example. The stop is an axially acting axial stop. The driving force is thus from the output member 8th about the questioning 9 in the case 1 derived.

The fourth embodiment of the 4a to 4c essentially corresponds to the third embodiment of the 3a to 3c with the difference that the challenge 9 rigid at the rear end of the output member 8th is formed and the stop of the housing 1 for the questioning 9 is resiliently formed on an arm. The stop of the housing 1 is designed as a Abragung, pointing radially inward on the mechanism holder 1b is formed. The resilient arrangement of the stop of the housing 1 simplifies the mountability of the delivery device.

Claims (16)

A delivery device for administering a liquid product, comprising: a) a housing ( 1 b) a product container with a piston displaceably arranged therein in the dispensing direction, c) a dose indicator element ( 2 ), which relative to the housing ( 1 ) is rotatably and translationally movable between a distal end position and a proximal end position, and d) an actuating button formed at the proximal end of the administering device ( 5 ) which is actuatable for a product distribution, wherein one on the operating button ( 5 ) applied driving force via a drive train ( 5 . 3 . 6 . 7 . 8th ) is transferable to the piston, whereby the piston is movable in the discharge direction, characterized by e) a device ( 9 ), which the driving force from the drive train ( 5 . 3 . 6 . 7 . 8th ) before the dose indicator ( 2 ) in its distal end position. Administration device according to claim 1, characterized by an output member ( 8th ), which pushes against the piston during dispensing, wherein the output member ( 8th ) is preferably a hollow piston rod, which at least for a part of a drive member ( 6 . 7 ), in particular for a drive rod ( 7 ) forms a passage. Administration device according to claim 2, characterized in that the drive member ( 6 . 7 ) in a threaded engagement with the output member ( 8th ), whereby the output member ( 8th ) upon rotation of the drive member ( 6 . 7 ) performs an axial movement in the discharge direction. Administration device according to claim 3, characterized in that the pitch of the threaded engagement between the output member ( 8th ) and drive member ( 6 . 7 ) is less than the pitch of a threaded engagement between dose indicator ( 2 ) and housing ( 1 ). Administration device according to one of the preceding claims, characterized in that the device ( 9 ) engages in two mutually different grooves, wherein a groove is a first thread and the other groove is a longitudinal guide or a second thread having a different pitch than the first thread. The delivery device of any of the preceding claims, characterized in that the device ( 9 ) is a ball, a ring or a segment of the ring, the ring having at least the first thread and the longitudinal guide or the second thread, wherein the first thread is an internal thread or an external thread and the second thread is an external thread or an internal thread or the longitudinal guide is arranged on the outside or on the inside of the ring. Administration device according to one of the preceding claims, characterized in that the device ( 9 ) in the housing ( 1 ), in particular in a rear housing part ( 1c ) or a mechanism holder ( 1b ), and a drive member ( 6 . 7 ) intervenes. Administration device according to one of the preceding claims, characterized in that at a dose setting a drive member ( 6 . 7 ) relative to the housing ( 1 ), in particular to a mechanism holder ( 1b ) or a rear housing part ( 1c ), is rotationally fixed and at a dose distribution relative to the housing ( 1 ) is rotatable so that, or that at a dose setting the device ( 9 ) relative to the housing ( 1 ) and when a dose is distributed the device ( 9 ) relative to the housing ( 1 ) rotatably and / or moved axially. Administration device according to one of the preceding claims, characterized in that the device ( 9 ) in an external thread of a mechanism holder ( 1b ) of the housing ( 1 ) and in a longitudinal guide of a drive member ( 6 . 7 ) intervenes. Administration device according to one of the preceding claims, characterized in that the device ( 9 ) in an internal thread of a rear housing part ( 1c ) and in a longitudinal guide of a drive member ( 6 . 7 ) intervenes. Administration device according to one of the preceding claims, wherein the device ( 9 ) on a driven member ( 8th ) is formed. Administration device according to one of the preceding claims, characterized in that the device ( 9 ) has an abutment surface which abuts a counter-abutment surface axially or circumferentially before the dose indicator ( 2 ) in its distal end position, wherein the counter-abutment surface preferably on or from the housing ( 1 ) is formed. Dispensing device according to one of the preceding claims, characterized in that the administering device comprises a rotary metering device ( 4 ) associated with the dose indicator ( 2 ) is kinematically coupled, wherein the dose indicator ( 2 ) upon rotation of the metering device ( 4 ) the combined translational-rotational movement relative to the housing ( 1 ). Administration device according to one of the preceding claims, characterized in that at the dose display element ( 2 ) a preferably helically encircling dose scale is arranged, which by one on the housing ( 1 ) readable reading range. Administration device according to one of the preceding claims, characterized in that kinematically between a coupling member ( 3 ) and the dose indicator ( 2 ) a coupling ( 3a ) is arranged, with which the coupling member ( 3 ) and the dose indicator ( 3 ) are rotatably coupled for a product distribution, wherein the coupling ( 3a ) is decoupled for a dose setting, so that between coupling member ( 3 ) and dose indicator ( 2 ) a rotating relative movement can take place. Administration device according to one of the preceding claims, characterized in that kinematically between a drive member ( 6 . 7 ) and the housing ( 1 ) a coupling ( 1d ) arranged to effect a rotational movement of the drive member (Fig. 6 . 7 ) in only one direction of rotation.

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