DE102009032119A1 - Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure - Google Patents
Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure Download PDFInfo
- Publication number
- DE102009032119A1 DE102009032119A1 DE102009032119A DE102009032119A DE102009032119A1 DE 102009032119 A1 DE102009032119 A1 DE 102009032119A1 DE 102009032119 A DE102009032119 A DE 102009032119A DE 102009032119 A DE102009032119 A DE 102009032119A DE 102009032119 A1 DE102009032119 A1 DE 102009032119A1
- Authority
- DE
- Germany
- Prior art keywords
- vascular prosthesis
- plastic
- middle layer
- coating
- layer made
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000011248 coating agent Substances 0.000 title claims abstract description 21
- 238000000576 coating method Methods 0.000 title claims abstract description 21
- 239000004033 plastic Substances 0.000 title claims abstract description 10
- 229920003023 plastic Polymers 0.000 title claims abstract description 10
- 229920000642 polymer Polymers 0.000 title abstract description 6
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052731 fluorine Inorganic materials 0.000 title abstract 2
- 239000011737 fluorine Substances 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 239000004814 polyurethane Substances 0.000 claims abstract description 4
- 229920002635 polyurethane Polymers 0.000 claims abstract description 3
- 230000002792 vascular Effects 0.000 claims description 42
- 239000000463 material Substances 0.000 claims description 7
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims description 4
- 229920002313 fluoropolymer Polymers 0.000 claims description 2
- 239000004811 fluoropolymer Substances 0.000 claims description 2
- 229920002742 polystyrene-block-poly(ethylene/propylene) -block-polystyrene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 abstract description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 abstract description 3
- 239000005977 Ethylene Substances 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- BUHVIAUBTBOHAG-FOYDDCNASA-N (2r,3r,4s,5r)-2-[6-[[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound COC1=CC(OC)=CC(C(CNC=2C=3N=CN(C=3N=CN=2)[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=2C(=CC=CC=2)C)=C1 BUHVIAUBTBOHAG-FOYDDCNASA-N 0.000 description 1
- 241001631457 Cannula Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 description 1
- 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 102000007625 Hirudins Human genes 0.000 description 1
- 108010007267 Hirudins Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000034827 Neointima Diseases 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- BXOUVIIITJXIKB-UHFFFAOYSA-N ethene;styrene Chemical group C=C.C=CC1=CC=CC=C1 BXOUVIIITJXIKB-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
- 229940006607 hirudin Drugs 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 229960002240 iloprost Drugs 0.000 description 1
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002482 oligosaccharides Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920005996 polystyrene-poly(ethylene-butylene)-polystyrene Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Die Erfindung betrifft eine hämokompatibel beschichtete Gefäßprothese nach dem Oberbegriff des Anspruchs 1.The The invention relates to a hemocompatible coated vascular prosthesis according to the preamble of claim 1.
Eine
gattungsgemäße Gefäßprothese
ist beispielsweise aus der
Eine
weitere beschichtete Gefäßprothese ist beispielsweise
aus der
Der Erfindung liegt die Aufgabe zugrunde, eine gegenüber dem Stand der Technik weiterentwickelte hämokompatible Gefäßprothese anzugeben.Of the Invention is based on the object, a relation to the State of the art further developed hemocompatible vascular prosthesis specify.
Diese
Aufgabe wird erfindungsgemäß gelöst durch
eine eine hämokompatible Beschichtung aufweisende Gefäßprothese
mit den Merkmalen des Anspruchs 1. Die Gefäßprothese
weist folgenden dreischichtigen Aufbau auf:
Die äußere
Schicht der Gefäßprothese ist durch einen Kunststoff
gebildet, der eine offene Struktur aufweist. Bei der offenen Struktur
handelt es sich beispielsweise um eine porige Struktur. Unter einer
porigen Struktur wird sowohl eine offenporige als auch eine geschlossenporige
Struktur verstanden. Alternativ ist die offene Struktur durch die
Herstellung der äußeren Schicht aus Fasern erzeugbar.
Besonders geeignet für die Herstellung sind Fluorpolymer-Kunststoffe,
insbesondere expandiertes Polytetrafluorethylen. Die offene Struktur
der äußeren Schicht ermöglicht die Einsprossung
von Bindegewebe, womit die Gefäßprothese im Körper
des Patienten fixiert wird.This object is achieved by a vascular prosthesis having a hemocompatible coating with the features of claim 1. The vascular prosthesis has the following three-layered structure:
The outer layer of the vascular prosthesis is formed by a plastic having an open structure. For example, the open structure is a porous structure. A porous structure is understood as meaning both an open-pore and a closed-pore structure. Alternatively, the open structure is producible by making the outer layer of fibers. Particularly suitable for the production are fluoropolymer plastics, in particular expanded polytetrafluoroethylene. The open structure of the outer layer allows the embedding of connective tissue, which fixes the vascular prosthesis in the body of the patient.
Als
mittlere Schicht der Gefäßprothese ist eine Kunststoffschicht
vorgesehen, welche im Gegensatz zur äußeren Schicht
eine geschlossene Struktur aufweist, wobei die genannten Schichten vorzugsweise
aus Werkstoffen unterschiedlicher chemischer Zusammensetzung hergestellt
sind. Ein geeigneter Werkstoff zur Herstellung der mittleren Schicht
ist zum Beispiel Polyurethan (PU). Als weitere für die
Herstellung der mittleren Schicht geeignete Materialien sind beispielsweise
SEES (Styrol-Ethylen/Butylen-Styrol-Triblock-Polymer) und SEPS (Styrol-Ethylen/Propylen-Styrol-Triblock-Polymer)
zu nennen. Eine Verwendung dieser Materialien in der Medizintechnik,
nämlich für Beutel, ist beispielsweise in der
Durch die porenfreie Struktur der mittleren Schicht wirkt diese als Bariere und verhindert damit ein Einwachsen von Gewebe in die Gefäßprothese über die äußere Schicht hinaus. Zumindest auf der Innenseite weist die mittlere Schicht eine glatte Oberfläche auf. Die an die äußere Schicht grenzende Außenoberfläche der mittleren Schicht kann im Vergleich hierzu eine größere Rauhigkeit aufweisen. Zusätzlich zu ihrer Barrierefunktion erfüllt die mittlere Schicht der Gefäßprothese eine mechanische Funktion. Insbesondere werden die elastischen Eigenschaften der Gefäßprothese zu einem wesentlichen Teil – neben der äußeren Schicht – durch die mittlere Schicht bestimmt. Bei geeigneter Auslegung der mittleren und äußeren Schicht ist die Gefäßprothese insbesondere als alloplastische Prothese (graft) herstellbar, welche einer nativen Arterie vergleichbare mechanische Eigenschaften hat.By the pore-free structure of the middle layer acts as barbers and thus prevents tissue from ingrowing into the vascular prosthesis the outer layer out. At least on the inside The middle layer has a smooth surface. The outer surface adjacent to the outer layer the middle layer may be larger in comparison Have roughness. In addition to its barrier function fills the middle layer of the vascular prosthesis a mechanical function. In particular, the elastic properties the vascular prosthesis to a substantial extent - in addition the outer layer - through the middle layer certainly. With suitable design of the middle and outer Layer is the vascular prosthesis in particular as alloplastic prosthesis (graft) can be produced, which is a native Artery has comparable mechanical properties.
Die
innerste Schicht der Gefäßprothese wird gebildet
durch eine hämokompatible Beschichtung, vorzugsweise eine
Beschichtung der in der
Durch die hämokompatible Beschichtung ist das Lumen der Gefäßprothese innert gegen die Besiedelung durch Fibroblasten und vollständig athrombogen. Die Entstehung einer neo-Intima (Gefäßinnenwand) in der Gefäßprothese wird durch die hämokompatible Beschichtung zuverlässig verhindert.By the hemocompatible coating is the lumen of the vascular prosthesis within against the colonization by fibroblasts and completely athrombogen. The emergence of a neo-intima (inner vessel wall) in the vascular prosthesis is characterized by the hemocompatible Coating reliably prevented.
Der Vorteil der Erfindung liegt insbesondere darin, dass durch einen dreilagigen Aufbau einer Gefäßprothese sowohl den unterschiedlichen Anforderungen einerseits an der Außenoberfläche und andererseits an der Innenoberfläche der Prothese Rechnung getragen wird, als auch die wesentlich durch die mittlere Schicht beeinflussten mechanischen Eigenschaften der Prothese anforderungsgerecht realisierbar sind. Es ist vorgesehen, die Bezeichnung „Perfect Graft” für die Gefäßprothese einzuführen.Of the Advantage of the invention is in particular that by a three-layer construction of a vascular prosthesis both the different requirements on the one hand on the outer surface and on the other hand on the inner surface of the prosthesis bill is worn, as well as the essential through the middle layer influenced mechanical properties of the prosthesis according to the requirements are feasible. It is intended to use the term "Perfect Graft "for the vascular prosthesis introduce.
Die erfindungsgemäße Vorrichtung ist sowohl zur Implantation als auch für extrakorporale Anwendungen, beispielsweise als arteriell-venöser Shunt für Dialysepatienten, geeignet. Eine dauerhafte Verwendung der ohne Beschränkung der Allgemeinheit als Gefäßprothese bezeichneten Vorrichtung ist ebenso möglich wie eine temporäre VerwendungThe Device according to the invention is both for implantation as well as for extracorporeal applications, for example as an arterial-venous shunt for dialysis patients, suitable. A permanent use of unlimited referred to the general public as a vascular prosthesis Device is possible as well as a temporary one use
Die Gefäßprothese ist in verschiedenen Durchmesserbereichen herstellbar, auch mit einem Innendurchmesser von weniger als 5 mm. Selbst Umgehungsanastomosen, insbesondere am Herz (köstlicher Bypass), sind mit der Gefäßprothese erzeugbar.The Vascular prosthesis is in different diameter ranges can be produced, even with an inner diameter of less than 5 mm. Even bypass anastomoses, especially on the heart (delicious Bypass) can be generated with the vascular prosthesis.
Nachfolgend
wird ein Ausführungsbeispiel der Erfindung anhand einer
Zeichnung näher erläutert. Hierin ist in einer
einzigen Figur in einer schematischen, nicht maßstäblichen
Schnittdarstellung eine Gefäßprothese
Die
Gefäßprothese
Eine äußere Schicht
An outer layer
An
die Innenoberfläche der äußeren Schicht
Auf
der Innenoberfläche der mittleren Schicht
Die
Beschichtung
- 11
- Gefäßprothesevascular prosthesis
- 22
- äußere Schichtouter layer
- 33
- mittlere Schichtmiddle layer
- 44
- hämokompatible Beschichtunghemocompatible coating
- 55
- Lumenlumen
ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION
Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.
Zitierte PatentliteraturCited patent literature
- - DE 10261986 B4 [0002, 0002, 0002, 0008, 0016] - DE 10261986 B4 [0002, 0002, 0002, 0008, 0016]
- - EP 1849434 A1 [0003] EP 1849434 A1 [0003]
- - EP 0765654 B1 [0006] - EP 0765654 B1 [0006]
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009032119A DE102009032119A1 (en) | 2009-06-26 | 2009-06-26 | Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009032119A DE102009032119A1 (en) | 2009-06-26 | 2009-06-26 | Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102009032119A1 true DE102009032119A1 (en) | 2010-12-30 |
Family
ID=43217994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102009032119A Withdrawn DE102009032119A1 (en) | 2009-06-26 | 2009-06-26 | Hemo-compatible-coated stent for fixation in body of patient, has outside layer made of fluorine polymer plastic having unclosed structure, middle layer made of plastic and coating, where outside layer has open-porous structure |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE102009032119A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010010483A1 (en) | 2010-02-28 | 2011-09-01 | Björn H. Koslar | Medical implant for connecting two vessels, such as transplant vessel and target vessel, has connecting element that is made of shape memory alloy, where connecting element is formed to roll implant around vessel in spiral manner |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0765654B1 (en) | 1995-09-29 | 2001-12-05 | Fresenius AG | Medical bag |
| EP1192957A2 (en) * | 2000-09-29 | 2002-04-03 | Ethicon, Inc. | Coating for medical devices |
| EP0842207B1 (en) * | 1995-08-03 | 2003-09-03 | Paul J. Santerre | Fluoroligomer surface modifiers for polymers and articles made therefrom |
| US20040063805A1 (en) * | 2002-09-19 | 2004-04-01 | Pacetti Stephen D. | Coatings for implantable medical devices and methods for fabrication thereof |
| US20040170685A1 (en) * | 2003-02-26 | 2004-09-02 | Medivas, Llc | Bioactive stents and methods for use thereof |
| DE29724864U1 (en) * | 1996-06-13 | 2004-11-04 | Boston Scientific Scimed, Inc., Marple Grove | Stent coating for drug release |
| DE102005021622A1 (en) * | 2005-05-05 | 2006-11-16 | Hemoteq Gmbh | A method for coating the net or mesh fabric of surgically used blood vessel stents has a first thin coating applied to the web material and a second thicker coating applied to the webs and gaps |
| DE102005040211A1 (en) * | 2005-08-16 | 2007-04-05 | Maquet Cardiopulmonary Ag | Use of nonionic esters in a coating for blood contacting surfaces |
| EP1849434A1 (en) | 2006-04-21 | 2007-10-31 | Stemberger, Axel, Prof.Dr.med. | Coating for stents |
| DE10261986B4 (en) | 2002-05-10 | 2008-01-31 | Hemoteq Ag | Hemocompatible coated surfaces, process for their preparation and their uses |
| DE102006038239A1 (en) * | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Drug-coated medical implants |
| DE102007034364A1 (en) * | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Degradable metal stent with active ingredient-containing coating |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010010483A1 (en) | 2010-02-28 | 2011-09-01 | Björn H. Koslar | Medical implant for connecting two vessels, such as transplant vessel and target vessel, has connecting element that is made of shape memory alloy, where connecting element is formed to roll implant around vessel in spiral manner |
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