DE102006024911A1 - Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier - Google Patents
Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier Download PDFInfo
- Publication number
- DE102006024911A1 DE102006024911A1 DE102006024911A DE102006024911A DE102006024911A1 DE 102006024911 A1 DE102006024911 A1 DE 102006024911A1 DE 102006024911 A DE102006024911 A DE 102006024911A DE 102006024911 A DE102006024911 A DE 102006024911A DE 102006024911 A1 DE102006024911 A1 DE 102006024911A1
- Authority
- DE
- Germany
- Prior art keywords
- emulsifier
- boswellic acid
- concentrate
- polysorbate
- solubilizate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003995 emulsifying agent Substances 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 235000013305 food Nutrition 0.000 title claims description 5
- 239000013543 active substance Substances 0.000 title abstract 2
- 239000000419 plant extract Substances 0.000 title abstract 2
- 239000000654 additive Substances 0.000 title 1
- 230000000996 additive effect Effects 0.000 title 1
- 239000002537 cosmetic Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 6
- NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 claims description 19
- NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 claims description 19
- 239000012141 concentrate Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 7
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 6
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 6
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 6
- 229940068977 polysorbate 20 Drugs 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 4
- 229950008882 polysorbate Drugs 0.000 claims description 4
- 240000007551 Boswellia serrata Species 0.000 claims description 3
- 235000012035 Boswellia serrata Nutrition 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000000693 micelle Substances 0.000 claims description 3
- 239000011874 heated mixture Substances 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- YJBVHJIKNLBFDX-MQURJEHKSA-N (3r,4r,4ar,6ar,6bs,8ar,11r,12s,12ar,14ar,14br)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1h-picene-4-carboxylic acid Chemical compound C1C[C@@H](OC(C)=O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C YJBVHJIKNLBFDX-MQURJEHKSA-N 0.000 description 3
- HMMGKOVEOFBCAU-BCDBGHSCSA-N 3-Acetyl-11-keto-beta-boswellic acid Chemical compound C1C[C@@H](OC(C)=O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC(=O)[C@@H]3[C@]21C HMMGKOVEOFBCAU-BCDBGHSCSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- HMMGKOVEOFBCAU-UHFFFAOYSA-N AKBA Natural products C1CC(OC(C)=O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CC(=O)C3C21C HMMGKOVEOFBCAU-UHFFFAOYSA-N 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229940075000 frankincense extract Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 208000037997 venous disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Die aus Pflanzenharz, beispielsweise Olibanum, gewonnene Boswellinsäure (gelegentlich auch Boswelliasäure genannt) ist seit Jahrtausenden als Hausmittel bekannt. Wesentliche Wirkstoffe sind insbesondere die 3-Acetyl-β-Boswellinsäure (Molekulargewicht 498,73, C32H50O4, CAS-Nr. 5968-70-7) oder die 3-Acetyl-11-Keto-β-Boswellinsäure (Molekulargewicht 512,73, C32H48O5, CAS-Nr.67416-61-9).The boswellic acid (sometimes called boswellic acid) derived from vegetable resin, such as Olibanum, has been known as a home remedy for millennia. Essential active ingredients are, in particular, 3-acetyl-β-boswellic acid (molecular weight 498.73, C 32 H 50 O 4 , CAS No. 5968-70-7) or 3-acetyl-11-keto-β-boswellic acid (molecular weight 512.73, C 32 H 48 O 5 , CAS No. 67416-61-9).
Mit verschiedenen Studien konnte gezeigt werden, dass die genannte Säure wie auch ihre Derivate bei folgenden Leiden und Krankheiten als wirksam und lindernd angesehen werden können: Asthma, chronische Entzündungen aller Art, Venenleiden, Rheuma, MS und andere. Boswellinsäure konnte auch bei der Vitalitäts- und Schmerztherapie mit Erfolg eingesetzt werden.With Various studies have shown that the acid mentioned also their derivatives in the following diseases and diseases as effective and alleviating: Asthma, chronic inflammation of all kinds, venous disorders, rheumatism, MS and others. Boswellic acid could also at the vitality and pain therapy can be used successfully.
Ein Problem besteht vielfach darin, dass im Organismus ein ausreichender Pegel an Boswellinsäure nur sehr schwer einzustellen und aufrecht zu erhalten ist.One The problem is often that in the organism a sufficient Level of boswellic acid only very difficult to adjust and maintain.
Der Erfindung liegt daher die Aufgabe zugrunde, ausreichende Gaben und Einstellungen von Boswellinsäure und/oder ihren Derivaten zu vereinfachen. Dazu sieht die Erfindung ein Konzentrat vor, das Boswellinsäure und/oder eines oder mehrere ihrer Derivate, Wasser und ein Micellen bildender, lebensmittelrechtlich unbedenklicher Emulgator mit einem HLB-Wert von 9-18 enthält, dessen gewichtsmäßiger Anteil am Konzentrat wenigstens das Sechsfache des Boswellinsäure-Anteils beträgt. Die durch die Micellen des Emulgators hydrophil gemachte Säure und ihre Derivate lassen sich nicht nur leichter sondern auch in höherer Konzentration verabreichen, so dass die Boswellinsäure und ihre Abkömmlinge wesentlich leichter bioverfügbar sind.Of the The invention is therefore based on the object, sufficient gifts and Settings of boswellic acid and / or their derivatives. This is what the invention looks like a concentrate that contains boswellic acid and / or one or more their derivatives, water and a micelle-forming, food safe Emulsifier with an HLB value of 9-18, its weight fraction on the concentrate at least six times the boswellic acid content is. The acid made hydrophilic by the micelles of the emulsifier their derivatives can be administered not only more easily but also in higher concentrations, so that the boswellic acid and their descendants much easier bioavailable are.
Mit besonderem Vorteil enthält das Konzentrat ein Extrakt, das etwa 85% Boswellinsäure aufweist und meist aus Boswellia Serrata gewonnen ist. Eine für viele Zwecke geeignete Zusammensetzung des Konzentrats zeichnet sich nach der Erfindung dadurch aus, dass es aus etwa 11,8 Gew% Extrakt, etwa 24,2 Gew% entionisiertes Wasser und etwa 64 Gew% Emulgator, der vornehmlich ein Polysorbat, also beispielsweise Polysorbat 20 ist, bezogen auf das Gesamtgewicht des Konzentrats = 100%, besteht.With contains particular advantage the concentrate is an extract containing about 85% boswellic acid and mostly from Boswellia Serrata. One for many Purpose suitable composition of the concentrate is characterized the invention characterized in that it consists of about 11.8 wt% extract, about 24.2 wt% deionized water and about 64 wt% emulsifier, the primarily a polysorbate, for example polysorbate 20, based on the total weight of the concentrate = 100%.
Ein Verfahren zur Herstellung des erfindungsgemäßen Konzentrats sieht vor, dass Wasser mit Boswellinsäure und/oder einem oder mehreren ihrer Derivate vermischt und die Mischung auf wenigstens 80°C, bevorzugt 87°C-93°C, erwärmt wird, dass ein Micellen bildender, lebensmittelrechtlich unbedenklicher Emulgator mit einem HLB-Wert von 9-18 in die erwärmte Mischung eingearbeitet, die Mischung mit dem Emulgator gut homogenisiert und nach der Homogenisierung auf etwa 50°C abgekühlt wird. Als Emulgator wird zweckmäßig ein Polysorbat, bevorzugt Polysorbat 20 eingesetzt. Ferner empfiehlt es sich, ein Extrakt zu verwenden, das etwa 85% Boswellinsäure enthält und beispielsweise aus Boswellia Serrata gewonnen wurde. Weiter ist günstig, wenn das Verhältnis des Gewichtsanteils an Emulgator zu dem Gewichtsanteil von Boswellinsäure zu etwa 6 : 1 gewählt wird.One Process for the preparation of the concentrate according to the invention provides that water with boswellic acid and / or one or more of their derivatives and the mixture to at least 80 ° C, preferred 87 ° C-93 ° C, heated, that a micelle-forming, food safe Emulsifier with an HLB value of 9-18 incorporated into the heated mixture, The mixture with the emulsifier well homogenized and after homogenization to about 50 ° C chilled becomes. As an emulsifier is appropriate Polysorbate, preferably polysorbate 20 used. Further recommends it is to use an extract containing about 85% boswellic acid and for example was won from Boswellia Serrata. Next is cheap, though The relationship the weight fraction of emulsifier to the weight fraction of boswellic acid to about 6: 1 selected becomes.
Ein
Ausführungsbeispiel
der Erfindung ist nachstehend angegeben. Dabei ist unter „Produktwasser" ein entionisiertes,
entmineralisiertes Wasser zu verstehen. Ausführungsbeispiel Zutaten:
Durchführung:Execution:
- • Produktwasser mit Weihrauch Extrakt-Pulver mischen und erwärmen (87-93°C).• product water mix with incense extract powder and heat (87-93 ° C).
- • Unter Beibehaltung der Temperatur Polysorbat 20 langsam in das Gemisch einarbeiten und alles gut homogenisieren.• Under Keep the temperature polysorbate 20 slowly in the mixture work in and homogenize everything well.
- • Es entsteht eine starke Schaumbildung – diese kann ignoriert werden, sofern bei de Probenahme ein klares Solubilisat am Boden des Abnahmegefäßes sichtbar ist• It Strong foaming occurs - this can be ignored provided that a clear solubilizate was visible at the bottom of the receptacle during sampling is
- • Abkühlen lassen und bei ca. 50°C abfüllen.• Let cool down and at about 50 ° C bottling.
Aussehen:Appearance:
Bräunlich, klar, viskos.Brownish, clear, viscous.
Lagerbedingungen:Storage conditions:
Dunkel und kühl (< 25°C).dark and cool (<25 ° C).
Verarbeitungshinweis:Processing information:
Bei der Herstellung auf der Produktionsanlage ist darauf zu achten, dass die Kontrolle der Klarheit (= Vollständige Micellierung) mittels Laserstrahl erfolgt.at the production on the production plant has to be ensured that the control of the clarity (= complete Micellierung) means Laser beam takes place.
Claims (8)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006024911A DE102006024911A1 (en) | 2006-05-24 | 2006-05-24 | Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier |
| PCT/EP2006/006655 WO2007006497A2 (en) | 2005-07-08 | 2006-07-07 | Solubilsation products of an active ingredient extract |
| US11/988,379 US20080220102A1 (en) | 2005-07-08 | 2006-07-07 | Solubilsation Products of an Active Ingredient Extract |
| EP06776151A EP1904042A2 (en) | 2005-07-08 | 2006-07-07 | Solubilsation products of an active ingredient extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006024911A DE102006024911A1 (en) | 2006-05-24 | 2006-05-24 | Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006024911A1 true DE102006024911A1 (en) | 2007-11-29 |
Family
ID=38622298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006024911A Ceased DE102006024911A1 (en) | 2005-07-08 | 2006-05-24 | Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE102006024911A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019011414A1 (en) * | 2017-07-11 | 2019-01-17 | Aquanova Ag | SOLUBILIZATION WITH CURCUMIN AND BOSWELLIA |
| WO2019011954A1 (en) * | 2017-07-11 | 2019-01-17 | Aquanova Ag | SOLUBILIZATION WITH CURCUMIN AND BOSWELLIA AND XANTHOHUMOL |
| AT525113A1 (en) * | 2021-05-31 | 2022-12-15 | Biocannovea Produktions & Vertriebs Gmbh | Process for preparing an aqueous solution containing Boswellia components |
| US11786484B2 (en) | 2018-07-11 | 2023-10-17 | Aquanova Ag | Xanthohumol solubilizate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60003537T2 (en) * | 1999-03-26 | 2003-12-24 | Quest Int | COMPOSITIONS CONTAINING BOSWELLIA EXTRACTS |
| US20040081670A1 (en) * | 2001-02-11 | 2004-04-29 | Dariush Behnam | Method for producing an active ingredient concentrate, and an active ingredient concentrate |
| DE102005032352A1 (en) * | 2005-07-08 | 2007-01-11 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Solubilizer for an active ingredient concentrate in the food industry comprises a St. John's wort extract, a roseda extract or a tarragon extract, a polysorbate emulsifier and water |
-
2006
- 2006-05-24 DE DE102006024911A patent/DE102006024911A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60003537T2 (en) * | 1999-03-26 | 2003-12-24 | Quest Int | COMPOSITIONS CONTAINING BOSWELLIA EXTRACTS |
| US20040081670A1 (en) * | 2001-02-11 | 2004-04-29 | Dariush Behnam | Method for producing an active ingredient concentrate, and an active ingredient concentrate |
| DE102005032352A1 (en) * | 2005-07-08 | 2007-01-11 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Solubilizer for an active ingredient concentrate in the food industry comprises a St. John's wort extract, a roseda extract or a tarragon extract, a polysorbate emulsifier and water |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019011414A1 (en) * | 2017-07-11 | 2019-01-17 | Aquanova Ag | SOLUBILIZATION WITH CURCUMIN AND BOSWELLIA |
| WO2019011954A1 (en) * | 2017-07-11 | 2019-01-17 | Aquanova Ag | SOLUBILIZATION WITH CURCUMIN AND BOSWELLIA AND XANTHOHUMOL |
| WO2019011955A3 (en) * | 2017-07-11 | 2019-05-16 | Aquanova Ag | Solubilisate with curcumin and optionally at least one other active substance |
| CN111163806A (en) * | 2017-07-11 | 2020-05-15 | 阿奎诺瓦股份公司 | Solubilizer with curcumin, frankincense and xanthohumol |
| RU2752078C1 (en) * | 2017-07-11 | 2021-07-22 | Акванова Аг | Solubilize with curcumin, and if necessary at least with one other active substance |
| US11197834B2 (en) | 2017-07-11 | 2021-12-14 | Aquanova Ag | Solubilizate with curcumin and optionally at least one other active substance |
| RU2771527C1 (en) * | 2017-07-11 | 2022-05-05 | Акванова Аг | Solubilisate with curcumin and at least one cannabinoid as an additional active substance |
| US11344509B2 (en) | 2017-07-11 | 2022-05-31 | Aquanova Ag | Solubilizate with curcumin and boswellia and xanthohumol |
| US11931322B2 (en) | 2017-07-11 | 2024-03-19 | Aquanova Ag | Solubilizate with curcumin and optionally at least one other active substance |
| US12144784B2 (en) | 2017-07-11 | 2024-11-19 | Aquanova Ag | Solubilizate with curcumin and optionally at least one other active substance |
| US11786484B2 (en) | 2018-07-11 | 2023-10-17 | Aquanova Ag | Xanthohumol solubilizate |
| AT525113A1 (en) * | 2021-05-31 | 2022-12-15 | Biocannovea Produktions & Vertriebs Gmbh | Process for preparing an aqueous solution containing Boswellia components |
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| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8131 | Rejection |