DE102005036752A1 - Cosmetic and pharmaceutical compositions containing isoalkanolalkoxilates - Google Patents

Abstract

The present invention relates to pharmaceutical and cosmetic agents which contain alcohol alkoxylates based on branched C¶10¶ alcohols as a component, surfactant mixtures based on these alcohol alkoxylates and the use of such alcohol alkoxylates.

Description

The present invention relates to pharmaceutical and cosmetic compositions which contain alcohol alkoxylates based on branched C ₁₀ -alcohols as component, surfactant mixtures based on these alcohol alkoxilates and the use of such alcohol alkoxilates.

drugs for the Cosmetics, but also for Medicines, hygiene products, material protection, etc., d. H. substances which already have an effect in low concentrations, z. As a cosmetic effect on the skin or hair, pharmacological Effect in an organism, etc., are often in the form of watery Drug formulations formulated and applied. Alternatively it is also a formulation and administration in solid form, e.g. B. as Powder or pellet (tablet, etc.) possible, with transport to the actual site of action, however, the conversion into an aqueous form includes.

One principal problem with aqueous Active ingredient preparations is the low water solubility of many active ingredients, the common less than 5 g / l at 23 ° C / 1013 mbar. aqueous Formulations of such agents can be considered heterogeneous systems be present, wherein the active ingredient as emulsified or dispersed Phase is present in a continuous aqueous phase. to Stabilization of these intrinsically metastable systems is becoming commonplace Emulsifiers or dispersants used. Their stabilizing Effect is common unsatisfactory, so that a deposition of the active ingredient, for example, creaming or sedimentation of the active ingredient, may occur, especially if the aqueous formulation is used for a longer time increased Temperature and / or at strongly changing temperatures or in the Near the Freezing point is stored. This problem is especially true then pronounced, if the active ingredient tends to crystallize. In addition, many times a solubilization, d. H. a solubility improvement by surfactants Compounds, which are poorly water-soluble or water-insoluble Substances in clear, at most opalescent aqueous Solutions transferred, without that here the chemical structure of these substances is a change experiences. These solubilizates are characterized by being bad water-soluble or water-insoluble Substance in the molecular associates the surface active Compounds that are in aqueous solution form solved is present. The resulting solutions are stable single-phase systems that are optically clear to opalescent appear and can be produced without energy input. solubilizers can For example, the appearance of cosmetic formulations as well of food preparations improve by the formulations make transparent. Furthermore In the case of pharmaceutical preparations also bioavailability and thus the effect of drugs through the use of Solubilizers are increased.

Become frequent also organic solvents for the preparation of aqueous Formulations of water-insoluble active ingredients used. This is often used water-miscible solvents as a solubilizer, d. H. to increase the solubility of the active ingredient in the aqueous Phase. In turn, water-immiscible solvents are used to a solid at application temperature drug in a liquid phase to convict the you can then emulsify. In contrast to the solid substance is the active ingredient over the solvent dissolved in the emulsion molecularly and better available for application and more effective. However, the use of organic solvents is on Reason of the known VOC problem for reasons of industrial hygiene, environmental aspects and sometimes undesirable for toxicological reasons.

When Surfactants referred to surface active Connections are extraordinary found wide use. Cosmetic and dermatological compositions, z. B. hair and skin cosmetic preparations, oral and dental care preparations, but also non-dermatological pharmaceutical compositions often have surfactants or surfactant mixtures. Such is for example Alcohol alkoxylates as surfactants in detergents and cleaners, in the metalworking industry, in manufacturing and processing textiles, in the leather, paper, printing, galvano and photographic industries, in water treatment, in pharmaceutical, veterinary and pesticide-related formulations, or in the Plastic manufacturing and plastics processing industry use. Both the structures of the alcohol part and the Alkoxylate part influence the properties of the alkoxylates, so that in the aforementioned applications various technical Effects can come to fruition. These include wetting, spreading, penetration, clinging, filming, improving tolerances, drift control and defoaming.

Thus, for example, in WO 01/77276, US-A 6,057,284 and US-A 5,661,121 determine te alcohol alkoxylates described as foam-suppressing surfactants. These surfactants are block-shaped alkoxylates whose alcohol part is branched. Various alcohol alkoxylates and their use are also described in WO 94/11330, WO 94/11331, WO 03/091190, WO 03/091191, WO 03/090531, WO 04/033403 and WO 04/033404.

Of the The present invention is based on the object, new surfactants for the Use in cosmetic and pharmaceutical compositions to disposal to deliver. These are to be used alone a good surface-active Have effect and as possible do not cause skin irritation. The invention is still the object underlying preparations of insoluble in water or sparingly soluble Active substances, in particular of active ingredients for cosmetics, pharmacy, Provide hygiene products and material protection. These drug compositions should be easy to produce and no or only a very small Content of volatile have organic substances. Furthermore, a high stability of the resulting aqueous Drug compositions with regard to segregation processes long storage and dilution desirable with water.

• A) wenigstens ein Isoalkanolalkoxilat, das durch Alkoxilierung wenigstens eines C₁₀-Isoalkanols mit wenigstens einem C₂- bis C₆-Alkylenoxid erhältlich ist,
• B) wenigstens ein von A) verschiedenes Tensid.

A first subject of the invention is a surfactant mixture containing

• A) at least one isoalkanol alkoxilate obtainable by alkoxylating at least one C ₁₀ isoalkanol with at least one C ₂ to C ₆ alkylene oxide,
• B) at least one different from A) surfactant.

• a) wenigstens ein Isoalkanolalkoxilat A), das durch Alkoxilierung wenigstens eines C₁₀-Isoalkanols mit wenigstens einem C₂- bis C₆-Alkylenoxid erhältlich ist,
• b) wenigstens einen kosmetisch oder pharmazeutisch akzeptablen Wirk- oder Effektstoff, und
• c) gegebenenfalls wenigstens einen weiteren kosmetisch oder pharmazeutisch akzeptablen Hilfsstoff.

Another object of the invention is a cosmetic or pharmaceutical agent containing

• a) at least one isoalkanol alkoxylate A) obtainable by alkoxylating at least one C ₁₀ isoalkanol with at least one C ₂ to C ₆ alkylene oxide,
• b) at least one cosmetically or pharmaceutically acceptable active or effect substance, and
• c) optionally at least one further cosmetically or pharmaceutically acceptable excipient.

It was surprisingly found that the inventively used Isoalkanolalkoxilate A) are suitable in an advantageous manner, water-insoluble (or only slightly soluble in water) Active and effect substances in aqueous Stabilize phase and the preparation of aqueous formulations of such To allow active and effect substances. They are also suitable for the preparation of solid formulations of these Active and effect substances, resulting in an aqueous formulation, eg. B. as a commercial, presentation or Wirkform, can convict. This can also be done only after application of the solid composition (eg in the digestive tract of an organism, etc.). The inventively used Isoalkanolalkoxilates A) are also very generally suitable for the preparation pigment-containing formulations with advantageous properties. For example, when used in combination with UV absorbers and / or for As a rule, the pigments used in the sunscreen are an improvement of the sun protection factor (SPF values, sun protection factors). The inventively used Isoalkanolalkoxilate A) also have in general very good Surfactant properties and are very suitable for formulating oil, grease and and / or wax-containing compositions, e.g. B. appropriate oil and shower rooms.

The with the inventively used Isoalkanolalkoxilaten A) achieved "solubility improvement" is in the context of Therefore, the present invention broadly understood. This includes the a stabilization of heterogeneous systems in which the active ingredient as emulsified or dispersed phase (disperse phase) in one aqueous Medium is present as a continuous phase. This continues to count the stabilization of transitional stages to homogeneous solutions, like colloidal solutions, etc., up to molecular disperse solutions. This also counts a solubility improvement in the sense of solubilization, in which the poorly water-soluble or water-insoluble Substances in clear, at most opalescent aqueous Solutions are transferred. Also includes after all also the ability to the formation of so-called "solid Solutions".

A low (poor) solubility in the context of this invention means a solubility of the active or effect substance in water of below 10 g / l, in particular below 1 g / l and especially below 0.1 g / l at 25 ° C and 1013 mbar.

The aqueous active substance compositions of water-insoluble active ingredients prepared using the isoalkanol alkoxylates A) comprise, in addition to an aqueous medium as the continuous phase, at least one active substance and / or effect substance solubilized or dispersed in the continuous phase and dissolved in water at 25 ° C. 1013 mbar have a solubility below 10 g / l, in particular below 1 g / l and especially below 0.1 g / l. The terms "aqueous medium" and "aqueous phase" Include water, aqueous mixtures of water with up to 10 wt .-%, based on the mixture, of organic solvents which are miscible with water, and solutions of solids in water or in the aqueous mixtures. Examples of water-miscible solvents include C ₃ -C ₄ ketones such as acetone and methyl ethyl ketone, cyclic ethers such as dioxane and tetrahydrofuran, C ₁ -C ₄ alkanols such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert. Butanol, polyols and their mono and dimethyl ethers such as glycol, propanediol, ethylene glycol monomethyl ether, diethylene glycol, diethylene glycol monomethyl ether, diethylene glycol dimethyl ether, glycerol, furthermore C ₂ -C ₃ nitriles such as acetonitrile and propionitrile, dimethyl sulfoxide, dimethylformamide, formamide, acetamide, dimethylacetamide, butyrolactone, 2-pyrrolidone and N-methylpyrrolidone.

One Advantage of the active ingredient compositions according to the invention is that they are also low in solvents (salary on fleeting Solvents <10 wt .-%, based on the weight of the active ingredient composition) or even solvent-free (Content of volatile Solvents <1 wt .-%, based on the weight of the active ingredient composition) can.

One Another advantage is the fact that the inventive aqueous Active ingredient compositions usually to a redispersible Let the powder dry. Ie. by removing the aqueous Phase during of drying a finely divided powder that dissolves readily in water or dispersing, without a significant increase in particle size occurs.

The isoalkanol alkoxylates A) used according to the invention, which are obtainable by alkoxylating at least one C ₁₀ isoalkanol with at least one C ₂ to C ₆ alkylene oxide, are known per se. For example, WO 94/11330, WO 94/11331, WO 03/091190, WO 03/091191, WO 03/090531, WO 04/033403 and WO 04/033404 describe suitable alkoxylates. The description of these alkoxylates in these references is hereby incorporated by reference, whereby the alkoxylates disclosed therein and also their preparation are part of the present disclosure.

Of the Alcohol portion of the alkoxylates to be used is branched. In this Meaning, the main chain of the alcohol moiety is preferably 1 to 5, more preferably 1 to 4 branches. The degree of branching V is preferably in the range of 0.1 to 0.5, more preferably 0.1 to 0.4. In the context of the present invention, the degree of branching is V molecular weight independent defined as the number of branches per carbon atom (V = number branching / number of carbon atoms, e.g. For example, n-octane: 0/8 = 0, methylheptane: 1/8 = 0.125, dimethylhexane: 2/8 = 0.25, propylheptane: 1/10 = 0.1).

in the In general, the branches independently of one another have 1 to 10, preferably 1 to 6 and especially 1 to 4 carbon atoms. Particular branches are methyl, ethyl, n-propyl or iso-propyl groups.

• – Oxoalkohole auf Basis von linearen oder verzweigten Olefinen,
• – sekundäre Alkohole, z. B. aus der Paraffinoxidation,
• – nach dem SHOP-Prozess erhaltene Alkohole,
• – nach dem GTL-Verfahren erhaltene Alkohole,
• – nach dem Fischer-Tropsch-Verfahren erhaltene Alkohole,
• – durch Olefin-Metathese und anschließende Hydroformylierung erhaltene Alkohole,
• – Alkohole aus einer Hydroformylierung zuvor isomerisierter Olefine, wie in der WO 98/23566 beschrieben.

The C ₁₀ isoalkanols used for the alkoxylation may be pure substances or mixtures. Also suitable are mixtures which have at least one C ₁₀ isoalkanols mixed with n-decanol and / or with further straight-chain or branched alcohols. The further alcohols preferably have 5 to 25, more preferably 8 to 20 and in particular 10 to 13 carbon atoms. Suitable further alcohols are in particular fatty alcohols derived from both natural sources, eg. B. by recovery and required or if desired, by hydrolysis, transesterification and / or hydrogenation of glycerides and fatty acids, as well as by a synthetic route, for. B. are obtainable by construction of educts having a smaller number of carbon atoms. So you get z. B. after the SHOP process (Shell Higher Olefine Process) starting from ethene olefin fractions with a suitable for further processing to surfactants carbon number. The functionalization of the olefins to the corresponding alcohols takes place z. B. by hydroformylation and hydrogenation. Suitable alcohols used in addition to the C ₁₀ -alkanols are, for example:

• Oxo alcohols based on linear or branched olefins,
• - secondary alcohols, eg. From paraffin oxidation,
• Alcohols obtained after the SHOP process,
• Alcohols obtained by the GTL process,
• Alcohols obtained by the Fischer-Tropsch process,
• Alcohols obtained by olefin metathesis and subsequent hydroformylation,
• Alcohols from a hydroformylation of previously isomerized olefins, as described in WO 98/23566.

For illustration only, some suitable alcohols may be mentioned which can be used (individually or in the form of mixtures) together with the C ₁₀ isoalkanols for alkoxylation: 2-dodecanol, 2-tridecanol, 2-hexadecanol, 2-octadecanol, 3-nonadecanol , 3-heptadecanol, 7-ethyl-3-dodecanol, 3-methyl-6-ethyl-2-nonanol, 3-methyl-2-hexadecanol, 3-methyl-2-octadecanol, etc.

For the alkoxylation it is preferred to use a C ₁₀ isoalkanol component which consists of at least 10% by weight, more preferably at least 50% by weight and in particular at least 75% by weight, of branched C ₁₀ -alcohols. According to a specific embodiment, the alkoxylation is carried out using a C ₁₀ isoalkanol component which is essentially completely, ie at least 95% by weight, more preferably at least 99% by weight, based on the total weight of the alcohols contained, of branched C ₁₀ Alcohols exists.

As preferred C ₁₀ isoalkanol component, so-called C ₁₀ "Guerbet" alcohols are suitable. Including within the meaning of the invention both Guerbet alcohols in the strict sense (ie alcohol mixtures that have emerged from the Guerbet reaction), and C ₁₀ isoalkanols, as they are typical for the Guerbet reaction, but from other sources (eg B. an oxo synthesis, etc.), understood. The Guerbet reaction is understood to be the formation of higher molecular weight alcohols from low molecular weight under the influence of alkali metals, especially Na, or copper at elevated temperatures and elevated pressure (see M. Guerbet, CR, Heb., Acad Sci., 128, 511, 1002 (1988) on the mechanism: N. Machemer, Angew. Chem., 64, 8, (1952), pp. 213-220). Suitable C ₁₀ isoalkanols can thus z. B. by condensation of at least one pentanol, selected from 1-pentanol, 2-pentanol, 3-pentanol, 2-methyl-1-butanol, 2-methyl-2-butanol, 3-methyl-1-butanol, 3-methyl 2-butanol and mixtures thereof. For the condensation, preference is given to using 1-pentanol, if appropriate in a mixture with at least one further of the abovementioned isomers. Particular preference is given to the Guerbet reaction using 1-pentanol.

• a) Propene zwecks Oligomerisierung mit einem geeigneten Katalysator in Kontakt bringen,
• b) aus dem Reaktionsgemisch eine C₉-Olefinfraktion isolieren,
• c) die C₉-Olefinfraktion durch Umsetzung mit Kohlenmonoxid und Wasserstoff in Gegenwart eines geeigneten Katalysators hydroformylieren und
• d) hydrieren.

According to a further preferred embodiment, C ₁₀ -oxo alcohols are used for the alkoxylation. The term "C ₁₀ oxo alcohol" refers to C ₁₀ alcohol mixtures whose main component of at least one branched C ₁₀ alcohol (isodecanol) is formed. Suitable C ₁₀ -oxo alcohols are generally obtainable by hydrogenation of hydroformylated trimer propene. In particular, you can

• a) bringing propenes into contact with a suitable catalyst for the purpose of oligomerization,
• b) isolating a C ₉ olefin fraction from the reaction mixture,
• c) hydroformylating the C ₉ olefin fraction by reaction with carbon monoxide and hydrogen in the presence of a suitable catalyst, and
• d) hydrogenate.

According to a further preferred embodiment, C ₁₀ -Iso alcohols are used for the alkoxylation, which are obtained starting from valeraldehyde by aldol condensation and subsequent hydrogenation. The preparation of valeraldehyde and isomers thereof can be carried out by hydroformylation of butene, as z. In US 4,287,370 ; Beilstein IV 1, 32 68; Ullmann Encyclopedia of Industrial Chemistry, 5th ed., Vol. A1, pp. 323 and 328 f. is described. Methods for carrying out the aldol condensation are known in principle to those skilled in the art and z. In US 5,434,313 and Organikum, VEB German publishing house of the sciences, 16th ed., Berlin 1986, S. 450 f. described.

Preferred as the C ₁₀ isoalkanol component is 2-propylheptanol and are alcohol mixtures which contain 2-propylheptanol. A preferred mixture contains 2-propylheptanol and 2-ethylhexanol and / or 2-butyloctanol.

The alkoxylation results from the reaction of the C ₁₀ isoalkanol component with suitable alkylene oxides, which generally have 2 to 6 and preferably 2 to 5 carbon atoms. Preferably, the alkylene oxides are selected from ethylene oxide (EO), 1,2-propylene oxide (PO), 1,2-butene oxide (1,2-BO), 2,3-butene oxide (2,3-BO), 2-methyl 1,2-propene oxide (isobutene oxide, IBO), 1,2-pentene oxide (1,2-PeO), 2,3-pentene oxide (2,3-PeO), 2-methyl-1,2-butene oxide, 3-methyl 1,2-butene oxide, 1,2-hexene oxide, 2,3-hexene oxides, 3,4-hexene oxide, 2-methyl-1,2-pentene oxide, and mixtures thereof. The alkylene oxides are preferably selected from ethylene oxide, 1,2-propylene oxide and mixtures thereof.

Of the Degree of alkoxylation, d. H. the average chain length of the polyether chains to be used according to the invention Alcohol alkoxylates can by the molar ratio of alcohol to alkylene oxide be determined. Preference is given to alcohol alkoxylates with about 1 to 100, preferably about 2 to 30, especially 3 to 20, especially 4 to 15 and especially 5 to 14 alkylene oxide units. Dependent on from the for the implementation chosen Amounts of alkylene oxide (s) and the reaction conditions the respective degree of alkoxylation results. This is it usually a statistical average, as the number of alkylene oxide units of the alcohol alkoxylates resulting from the reaction varied.

One Type of isoalkanol alkoxylates to be used based on an alkylene oxide type. Preferably, the alkylene oxide is then selected from ethylene oxide, 1,2-propylene oxide (PO), 1,2-butene oxide (1,2-BO), 2,3-butene oxide (2,3-BO) and 2-methyl-1,2-propene oxide (Isobutene oxide, IBO). Particularly preferably, the alkylene oxide is selected under Ethylene oxide and 1,2-propylene oxide. Specifically, it is ethylene oxide Homoalkoxilate.

Another type of isoalkanol alkoxylates to use is based on at least two different types of alkylene oxide. If desired, the alkylene oxides can be incorporated randomly. For this purpose, the alkylene oxides can be used in the form of mixtures for alkoxylation. In order to achieve statistical incorporation in alkylene oxides with greatly different reactivities, it may be necessary to use an alkylene oxide in a significant excess or, as in the preparation of corresponding block copolymers, to carry out the alkoxylation successively (sequentially). Preferably, the alkylene oxide units are arranged in a block, so that at least two different alkylene oxide blocks result, which are each formed from a plurality of units of the same alkylene oxides. If such block alkoxylates are used, it is preferred for the alkylene oxide part to be composed of 2 to 5, preferably 2 or 3 and in particular 2 blocks. The block copolyethers may be prepared by reacting an alcohol of the formula R-OH wherein R is branched C ₁₀ alkyl (optionally in admixture with at least one other linear or branched alcohol as described above) with a first alkylene oxide, then reacting with one of them different second alkylene oxide and optionally further sequential addition of each one of the just previously added alkylene oxide different alkylene oxide are obtained until the desired block structure is achieved.

a According to one aspect, it is preferred that the invention be used Isoalkanolalkoxilate ethoxylated or at least one ethylene oxide block exhibit.

Preferably, the Isoalkanolalkoxilate A) are selected from compounds of the formula I. RO- (Alk ¹ O) _x - (Alk ² O) _y - (Alk ³ O) _z -H (I) wherein
R is branched C ₁₀ -alkyl,
Alk ¹ , Alk ² and Alk ³ independently of one another are straight-chain or branched C ₂ -C ₅ -alkylene groups, Alk ¹ and Alk ² and Alk ² and Alk ³ , if present, differing in terms of their carbon atom number or structure,
x + y + z is a number from 1 to 100.

Alk ¹ , Alk ² and Alk ³ are generally selected from 1,2-alkanediyl groups having 2 to 5 carbon atoms such as 1,2-ethylene, 1,2-propylene, 1,2-butylene, cis-2,3-butylene , trans-2,3-butylene, 1-methyl-1,2-propanediyl, 1,2-pentylene, etc.

The Variables x, y, and z denote averages, which are considered average of all molecules result. Therefore, you can the values for x, y and z also differ from integer values.

According to a preferred embodiment Isoalkanolalkoxilate A) of the formula (I) are used in which Alk ¹ is 1,2-ethylene, x is a number from 1 to 100 and y and z are 0th Preferably, x then stands for 2 to 30, in particular 3 to 20, especially 4 to 15 (eg for 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14).

Another preferred embodiment is EO-PO alkoxylates in which the ethylene oxide block is attached to the alcohol moiety. These include isoalkanol alkoxides A) of formula (I) wherein Alk ^{1 is} 1,2-ethylene, Alk ^{2 is} 1,2-propylene, x is a number from 1 to 20, and y is a number greater than zero and less than or equal to 6 and z stands for 0.

Prefers are EO-PO block alkoxylates in which the ratio of EO to PO (x to y) 1: 1 to 4: 1 and in particular 1.5: 1 to 3: 1. The degree of ethoxylation is thereby (Value of x) usually 1 to 20, preferably 2 to 15 and in particular 4 to 10, the degree of propoxylation (value of y) usually 1 to 20, preferably 1 to 8 and especially 2 to 5. The Gesamtalkoxylilierungsgrad, d. H. the sum of EO and PO units is usually 2 to 40, preferably 3 to 25 and especially 6 to 15.

Another preferred embodiment is EO-PO alkoxilates wherein the propylene oxide block is attached to the alcohol moiety. These include isoalkanol alkoxides A) of the formula (I) wherein Alk ^{1 is} 1,2-propylene, Alk ^{2 is} 1,2-ethylene, x is a number greater than 0 and less than or equal to 6, y is is a number from 1 to 20 and z stands for 0.

Prefers are PO-EO block alkoxylates in which the ratio of PO to EO (x to y) 1:10 to 3: 1 and especially 1.5: 1 to 1: 6. The degree of ethoxylation is thereby (Value of y) usually 1 to 20, preferably 2 to 15 and in particular 4 to 10, the degree of propoxylation (value of x) is usually 0.5 to 10, preferably 0.5 to 6 and especially 1 to 4. The Gesamtalkoxilierungsgrad, d. H. the sum of EO and PO units is usually 1.5 to 30, preferably 2.5 to 21 and in particular 5 to 14.

According to one another particular embodiment Alcohol alkoxylates of the formula (I) are used, wherein the values of x, y and z all bigger than Are zero. Belong to these especially EO-PO-EO block alkoxylates.

in the Within this preferred embodiment Based on Guebert alcohols are mainly alkoxylates of EO type for use. Of these, especially the corresponding ethoxylated To name 2-propylheptanols.

The Reaction of the alcohols or alcohol mixtures with the alkylene oxide (s) takes place according to usual, known to those skilled in the art and in customary apparatuses for working equipped under pressure.

The alkoxylation can be catalyzed by strong bases, such as alkali metal hydroxides and alkaline earth metal hydroxides, Brönsted acids or Lewis acids, such as AlCl ₃ , BF _3, etc. For narrow alcohol alkoxylates, catalysts such as hydrotalcite or double metal cyanides (DMC) can be used.

The Alkoxylation is preferably carried out at temperatures of about 90 to 240 ° C, especially preferably from 110 to 190 ° C carried out. The alkylene oxide or the mixture of different alkylene oxides is the mixture of inventively used Alcohol or alcohol mixture and catalyst under the at the selected reaction temperature prevailing vapor pressure of the alkylene oxide mixture or a higher pressure fed.

If desired, the alkylene oxide can be diluted with an inert gas (for example, noble gases, nitrogen, CO ₂ ) up to 99.9%. As a result, in particular in the case of ethylene oxide, additional safety is provided against the gas phase decomposition of this alkylene oxide, it also being possible in this embodiment for a further alkylene oxide, for example propylene oxide, to be used as the inert gas in the context of the invention.

suitable Alkoxylation conditions are also in Nikolaus Schönfeldt, Surface-active ethylene oxide adducts, Scientific Verlagsgesellschaft mbH, Stuttgart 1984 described. In general, the alkoxylation in the presence of the catalyst without addition of a solvent carried out. However, the alkoxylation can also with the concomitant use of a the alkoxylation of inert solvent.

In a suitable design the alkoxylation is catalyzed by at least one strong base. suitable Strong bases are z. B. alkali metal, alkali metal hydroxides, alkaline earth oxides or alkaline earth hydroxides. The bases are usually in one Amount of 0.01 to 1 wt .-% based on the amount of the alkoxylating Alcohol used (see G. Gee et al., J. Chem. Soc. (1961), P. 1345; B. Wojtech, Makromol. Chem. 66, (1966), p. 180).

Acid catalysis of the alkoxylation reaction is also possible. In addition to Bronsted acids are also Lewis acids such as AlCl ₃ , BF ₃ , BF ₃ -Dietherate, BF ₃ × H ₃ PO ₄ , SbCl ₄ × 2 H ₂ O, hydrotalcite (see PN Plesch, The Chemistry of Cationic Polymerization, Pergamon Press, New York (1963)).

In a further embodiment the alkoxylation is in the presence of a double metal cyanide compound carried out as a catalyst. As a DMC connection can in principle all suitable compounds known to the person skilled in the art be used.

DMC compounds suitable as catalyst are described, for example, in WO 99/16775 and DE-A-101 17 273. In particular, double metal cyanide compounds of general formula 1 are suitable as catalysts for the alkoxylation: M ¹ _a [M ² (CN) _b (A) _c ] _d * fM ¹ _g X _n * h (H ₂ O) * eL * kP wherein
M ^{1 is} at least one metal ion selected from Zn ²⁺ , Fe ²⁺ , Fe ³⁺ , Co ³⁺ , Ni ²⁺ , Mn ²⁺ , Co ²⁺ , Sn ²⁺ , Pb ²⁺ , Mo ^{4 +} , Mo ⁶⁺ , Al ³⁺ , V ⁴⁺ , V ⁵⁺ , Sr ²⁺ , W ⁴⁺ , W ⁶⁺ , Cr ²⁺ , Cr ³⁺ , Cd ²⁺ , Hg ²⁺ , Pd ²⁺ , Pt ²⁺ , V ²⁺ , Mg ²⁺ , Ca ²⁺ , Ba ²⁺ , Cu ²⁺ , La ³⁺ , Ce ³⁺ , Ce ⁴⁺ , Eu ³⁺ , Ti ³⁺ , Ti ⁴⁺ , Ag ⁺ , Rh ²⁺ , Rh ³⁺ , Ru ²⁺ and Ru ³⁺ ,
M ^{2 is} at least one metal ion selected from Fe ²⁺ , Fe ³⁺ , CO ²⁺ , Co ³⁺ , Mn ²⁺ , Mn ³⁺ , V ⁴⁺ , V ⁵⁺ , Cr ²⁺ , Cr ^{3 +} , Rh ³⁺ , Ru ²⁺ and Ir ³⁺ ,
A and X, independently of one another, are an anion selected from halide, hydroxide, sulfate, carbonate, cyanide, thiocyanate, isocyanate, cyanate, carboxylate, oxalate, nitrate, nitrosyl, hydrogensulfate, phosphate, dihydrogenphosphate, hydrogenphosphate and bicarbonate,
L is a water-miscible ligand selected from alcohols, aldehydes, ketones, ethers, polyethers, esters, polyesters, polycarbonate, ureas, amides, primary, secondary and tertiary amines, pyridine-nitrogen ligands, nitriles, sulfides, phosphides , Phosphites, phosphines, phosphonates and phosphates,
k is a fractional or integer greater than or equal to zero,
P is an organic additive,
a, b, c, d, g and n are selected so as to ensure the electroneutrality of the compound (I), where c = 0,
e is the number of ligand molecules is a fractional or integer greater than 0 or 0, and
f and h independently of one another are a fractional or integer greater than 0 or 0.

suitable organic additives P are: polyethers, polyesters, polycarbonates, Polyalkylene glycol sorbitan ester, polyalkylene glycol glycidyl ether, polyacrylamide, Poly (acrylamidcoacrylsäure) polyacrylic acid, Poly (acrylamidcomaleinsäure) Polyacrylonitrile, polyalkyl acrylates, polyalkyl methacrylates, polyvinyl methyl ether, polyvinyl ethyl ether, Polyvinyl acetate, polyvinyl alcohol, poly-N-vinylpyrrolidone, poly (N-vinylpyrrolidone-co-acrylic acid), polyvinyl methyl ketone, Poly (4-vinylphenol), poly (acrylic acid-co-styrene), Oxazoline polymers, polyalkyleneimines, maleic and maleic anhydride copolymers, Hydroxyethylcellulose, polyacetates, ionic surface and surfactants Compounds, bile acid or their salts, esters or amides, carboxylic acid esters of polyhydric alcohols and glycosides.

The DMC catalysts can be crystalline or amorphous. For the case of k being zero is crystalline double metal cyanide compounds prefers. In the case that k is greater than zero are crystalline, semicrystalline, as well as substantial amorphous catalysts are preferred. From the modified catalysts There are various preferred embodiments. A preferred embodiment are catalysts of the formula (I) in which k is greater than zero is. The preferred catalyst then contains at least one double metal cyanide compound, at least one organic ligand and at least one organic Additive P.

at another preferred embodiment k is zero, optionally e is also zero and X is exclusively one Carboxylate, preferably formate, acetate and propionate. Such catalysts are described in WO 99/16775. In this embodiment For example, crystalline double metal cyanide catalysts are preferred. Further preferred are double metal cyanide catalysts, as in WO 00/74845 described which are crystalline and platelike.

The Production of the modified catalysts is carried out by combining a metal salt solution with a cyanometalate solution, the optional both an organic ligand L and a organic additive P may contain. Then be the organic ligand and optionally the organic additive added. In a preferred embodiment The catalyst preparation is first an inactive double metal cyanide phase made and this afterwards converted by recrystallization in an active double metal cyanide phase, such as described in PCT / EP01 / 01893.

In another preferred embodiment of the catalysts, f, e and k are not equal to zero. These are double metal cyanide catalysts containing a water-miscible organic ligand (generally in amounts of from 0.5 to 30% by weight) and an organic additive (generally in amounts of from 5 to 80% by weight). contained as described in WO 98/06312. The catalysts can be prepared either with vigorous stirring (24,000 rpm, eg with Ultra-Turrax) or with stirring as in the US 5,158,922 described.

Especially are for the alkoxylation DMC catalyst suitable for the zinc, cobalt or Containing iron or two of these metals.

Prefers Crystalline DMC compounds are used. In a preferred Embodiment is uses a crystalline Zn-Co type DMC compound as a catalyst, which contains zinc acetate as a further metal salt component. such Compounds crystallize in monoclinic structure and have a platelet-shaped habit on. Such compounds are described, for example, in WO 00/74845 or PCT / EP01 / 01893.

When Catalyst suitable DMC compounds can in principle on all the Professional known species are produced. For example, the DMC compounds by direct precipitation, "incipient wetness" method, by production a precursor phase and subsequent recrystallization become.

The DMC connections can be used as a powder, paste or suspension or deformed into a shaped body be, in moldings, foams or similar be introduced or applied to moldings, foams or the like.

The related to the alkoxylation catalyst concentration on the final set framework is typically less than 2000 ppm (i.e., mg of catalyst per kg of product), preferably less than 1000 ppm, in particular smaller as 500 ppm, more preferably less than 100 ppm, for example less than 50 ppm or 35 ppm, more preferably less than 25 ppm.

• A) wenigstens ein Isoalkanolalkoxilat, das durch Alkoxilierung wenigstens eines C₁₀-Isoalkanols mit wenigstens einem C₂- bis C₆-Alkylenoxid erhältlich ist, und
• B) wenigstens ein von A) verschiedenes Tensid.

The surfactant mixture according to the invention contains:

• A) at least one Isoalkanolalkoxilat, which is obtainable by alkoxylation of at least one C ₁₀ isoalkanols with at least one C ₂ - to C ₆ alkylene oxide, and
• B) at least one different from A) surfactant.

in principle useful as surfactants B) are anionic, cationic, nonionic and amphoteric surfactants, wherein polymer surfactants and surfactants with heteroatoms are included in the hydrophobic group.

suitable anionic emulsifiers B) are, for example, selected from Carboxylates, alkyl ether carboxylates, alkyl sulfates, alkyl ether sulfates, Alkyl sulfonates, aryl sulfonates, alkylaryl sulfonates, alkyl succinates, Alkyl sulfosuccinates, N-acyl sarcosinates, N-acyl taurates, acyl isothionates, N-acylglutamates, alkyl phosphates, alkyl ether phosphates, methylcelluloses, Condensation products of sulfonated naphthalene and derivatives thereof with formaldehyde, condensation products of naphthalenesulfonic acids, phenolic and / or phenolsulfonic with formaldehyde or with formaldehyde and urea, protein hydrolysates, Lignin liquors and mixtures thereof.

suitable Carboxylates are especially alkali, alkaline earth and ammonium salts of fatty acids, z. As potassium stearate, which is commonly also called soaps.

Alkyl sulfates, alkyl ether sulfates and alkyl sulfonates preferably have a C ₈ -C ₃₀ -alkyl radical, particularly preferably a C ₉ -C ₂₂ -alkyl radical, in particular a C ₁₀ -C ₁₆ -alkyl radical. In particular, these compounds are present as alkali metal (eg Na or K), alkaline earth metal (eg Ca or Mg), ammonium or trialkanolamine (eg triethanolamine) salts. Alkyl ether sulfates preferably have 1 to 20, particularly preferably 1 to 10 and in particular 1 to 3 alkylene oxide units. The ether groups are preferably derived from ethylene oxide, propylene oxide and mixtures thereof and especially from ethylene oxide.

When Alkyl sulfonates and alkylaryl sulfonates are especially alkali, Alkaline earth and ammonium salts of arylsulfonic acids and alkyl-substituted arylsulfonic prefers. These include alkylbenzenesulfonic such as dodecylbenzenesulfonates, lignin and phenolsulfonic acid, naphthalene and alkylnaphthalenesulfonates such as dibutylnaphthalenesulfonic acids, etc.

suitable Alkyl succinates are especially alkali, alkaline earth and ammonium salts of succinic monoalkyl esters. Suitable alkylsulfosuccinates are mono- or dialkylsuccinic acid sulfonates which z. B. by addition of sodium bisulfite to succinic mono- or diesters available are.

Suitable N-acylsarcosinates are in particular alkali, alkaline earth and ammonium salts of compounds of the general formula R ^a -CO-N (CH ₃ ) -CH ₂ -COOH in which R ^a -CO is a radical derived from a fatty acid, e.g. As lauroyl, stearoyl, oleoyl, etc., stands. Suitable N-acyl taurates are, in particular, alkali metal, alkaline earth metal and ammonium salts of compounds of the general formula R ^a -CO-NH ₂ -CH ₂ -CH ₂ -SO ₃ H, where R ^a -CO has the meaning given above. Suitable acyl isothionates are, in particular, alkali metal, alkaline earth metal and ammonium salts of compounds of the general formula R ^a -C (= O) O-CH ₂ -CH ₂ -SO ₃ H, wherein R ^a -CO has the meaning given above. Suitable N-acylglutamates are, in particular, alkali metal, alkaline earth metal and ammonium salts of compounds of the general formula HOOC-CH ₂ -CH ₂ -CH (NH-CO-R ^a ) -COOH, where R ^a -CO has the meaning given above.

Suitable alkyl phosphates are, in particular, mono- and diphosphoric acid alkyl esters which contain one or two C ₈ -C ₃₀ -alkyl radicals, more preferably C ₉ -C ₂₂ -alkyl radicals, in particular C ₁₀ -C ₁₆ -alkyl radicals. In particular, these compounds are present as alkali metal (eg Na or K), alkaline earth metal (eg Ca or Mg), ammonium or trialkanolamine (eg triethanolamine) salts. Alkyl ether phosphates preferably have 1 to 20, particularly preferably 1 to 10 and in particular 1 to 3 alkylene oxide units. The ether groups are preferably derived from ethylene oxide, propylene oxide and mixtures thereof and especially from ethylene oxide.

To the cationic surfactants B) for example, quaternized ammonium compounds, in particular alkyltrimethylammonium and dialkyldimethylammonium halides and alkyl sulfates and pyridine and imidazoline derivatives, in particular Alkylpyridinium halides. Examples of cationic emulsifiers are Cetyidimethyl-2-hydroxyethylammonium dihydrogenphosphate, Cetyltrimonium chloride, cetyltrimmonium bromide, cocotrimonium methylsulfate, Quaternium-1 to x (INCI).

• – Aminoxide,
• – Fettalkoholpolyoxyethylenester, beispielsweise Laurylalkoholpolyoxyethylenetheracetat,
• – von Komponente A) verschiedene Alkyl-Polyoxyethylen- und -polyoxypropylenether,
• – Alkylarylalkohol-Polyoxyethylenether, z. B. Octylphenol-Polyoxyethylenether,
• – alkoxylierte tierische und/oder pflanzliche Fette und/oder Öle, beispielsweise Maisölethoxylate, Rizinusölethoxylate, Talgfettethoxylate,
• – Glycerinester, wie beispielsweise Glycerinmonostearat,
• – von Komponente A) verschiedene Fettalkoholalkoxylate und Oxoalkoholalkoxylate, insbesondere vom Typ RO-(R₁₈O)_r(R₁₉O)_sR₂₀ mit R₁₈ und R₁₉ unabhängig voneinander = C₂H₄, C₃H₆, C₄H₈ und R₂₀ = H, oder C₁-C₁₂-Alkyl, R = C₃-C₃₀-Alkyl oder C₆-C₃₀-Alkenyl, r und s unabhängig voneinander 0 bis 50, wobei nicht beide für 0 stehen können, wie iso-Tridecylalkohol und Oleylalkoholpolyoxyethylenether,
• – Alkylphenolalkoxylate, wie beispielsweise ethoxyliertes iso-Octyl-, Octyl- oder Nonylphenol, Tributylphenolpolyoxyethylenether,
• – Fettaminalkoxylate, Fettsäureamid- und Fettsäurediethanolamidalkoxylate, insbesondere deren Ethoxylate,
• – Zuckertenside, Sorbitester, wie beispielsweise Sorbitanfettsäureester (Sorbitanmonooleat, Sorbitantristearat), Polyoxyethylensorbitanfettsäureester, Alkylpolyglycoside, N-Alkylgluconamide,
• – Alkylmethylsulfoxide,
• – Alkyldimethylphosphinoxide, wie beispielsweise Tetradecyldimethylphosphinoxid.

The nonionic surfactants B) include, for example:

• - amine oxides,
• Fatty alcohol polyoxyethylene esters, for example lauryl alcohol polyoxyethylene ether acetate,
• Alkyl-polyoxyethylene and -polyoxypropylene ethers other than component A),
• Alkylaryl alcohol polyoxyethylene ethers, e.g. Octylphenol polyoxyethylene ether,
• Alkoxylated animal and / or vegetable fats and / or oils, for example corn oil ethoxylates, castor oil ethoxylates, tallow fat ethoxylates,
• Glycerol esters, such as glycerol monostearate,
• - Of component A) different fatty alcohol alkoxylates and Oxoalkoholalkoxylate, in particular of the type RO- (R ₁₈ O) _r (R ₁₉ O) _s R ₂₀ with R ₁₈ and R ₁₉ independently = C ₂ H ₄ , C ₃ H ₆ , C ₄ H ₈ and R ₂₀ = H, or C ₁ -C ₁₂ -alkyl, R = C ₃ -C ₃₀ -alkyl or C ₆ -C ₃₀ -alkenyl, r and s are independently 0 to 50, wherein not both are 0 such as iso-tridecyl alcohol and oleyl alcohol polyoxyethylene ether,
• Alkyl phenol alkoxylates, such as, for example, ethoxylated isooctyl, octyl or nonylphenol, tributylphenol polyoxyethylene ethers,
• Fatty amine alkoxylates, fatty acid amide and fatty acid diethanolamide alkoxylates, in particular their ethoxylates,
• Sugar surfactants, sorbitol esters such as sorbitan fatty acid esters (sorbitan monooleate, sorbitan tristearate), polyoxyethylene sorbitan fatty acid esters, alkylpolyglycosides, N-alkylgluconamides,
• - alkylmethyl sulfoxides,
• - Alkyldimethylphosphinoxide, such as Tetradecyldimethylphosphinoxid.

When Nonionic surfactants are preferably amine oxides for combination with the isoalkanol alkoxylates A). Suitable are especially aliphatic and cycloaliphatic amine oxides. These include z. Cocoamidopropylamine oxide, N-cocomorpholine oxide, decyldimethylamine oxide, dimethylcetylamine oxide, Dimethylcocoamine oxide, dimethyl-hydr. Tallow amine oxide, dimethyl lauryl amine oxide, Dimethyl myristyl amine oxide, (2-hydroxyethyl) cocoamine oxide, oleamine oxide. Also suitable are amine oxides based on a long-chain and two short-chain alkyl radicals attached to the nitrogen atom, as they are sold under the name Aminox C-55 (Beacon Chem.), and 1-alkoylamino-3-dimethylaminopropane-3-N-oxide, which is the amine oxide WS 35 is sold by Goldschmidt. Take at acidic pH the amine oxides limit cationic character, which also causes them for one Use as a hair care product (good combability) and skin care products (Skin smoothing) suitable are.

Further examples for preferred nonionic emulsifiers (INCI nomenclature) are Laurethe, z. Laureth-4; Cetethe, z. Cetheth-1, polyethylene glycol cetyl ether; Cetearethe, z. Cetheareth-25.

worin R¹ für einen langkettigen C₈-C₃₀-Alkylrest steht und R² und R³ unabhängig voneinander für C₁-C₄-Alkylreste stehen, die gegebenenfalls zusätzlich substituiert sein können. So steht R¹ z. B. für Decyl, Cetyl, Lauryl, Myristyl, Stearyl, etc. R² und R³ stehen z. B. unabhängig voneinander für Methyl, Ethyl oder Hydroxyethyl. Geeignet sind auch Tegobetaine, wobei der Rest R¹ eine Amidbindung enthält, und Sulfobetaine, welche anstelle der Carboxylat- eine Sulfonatgruppe aufweisen.The amphoteric surfactants B) include carboxybetaines and sulfobetaines. Suitable carbo-betaines are compounds of the formula

wherein R ^{1 is} a long-chain C ₈ -C ₃₀ -alkyl radical and R ² and R ³ independently of one another are C ₁ -C ₄ -alkyl radicals which may optionally be additionally substituted. So R ¹ z. B. for decyl, cetyl, lauryl, myristyl, stearyl, etc. R ² and R ³ are, for. B. independently of one another methyl, ethyl or hydroxyethyl. Also suitable are tegobetaines, where the radical R ¹ contains an amide bond, and sulfobetaines which have a sulfonate group instead of the carboxylate.

Further Surfactants B), which are to be mentioned by way of example here, are perfluorosurfactants, Silicone surfactants, phospholipids, such as lecithin or chemically modified lecithins, amino acid surfactants, e.g. B. N-lauroylglutamate.

Provided unspecified, the alkyl chains are those above listed Surfactants to linear or branched radicals having usually 8 to 20 carbon atoms.

The surfactant mixtures according to the invention preferably comprise at least one isoalkanol alkoxylate A) and at least one anionic surfactant B) other than A), as defined above. In a specific embodiment, the surfactant mixtures according to the invention consist exclusively of at least one isoalkanol alkoxylate A) and at least one anionic surfactant B) other than A). More preferably, the anionic surfactant B) is chosen from C ₈ -C ₃₀ alkyl sulfates, C ₈ -C ₃₀ alkyl ether sulphates, C ₈ -C ₃₀ alkyl sulfonates, and mixtures thereof. In combination with such anionic surfactants, the isoalkanol alkoxylates A) used according to the invention have a particular effect on their skin irritation-reducing action. Furthermore, they are particularly suitable to enhance the cleaning effect of these anionic surfactants.

The surfactant mixtures according to the invention The isoalkanol alkoxylates A) preferably contain in an amount from 0.01 to 50% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 0.1 to 10% by weight, based on the total weight of the Surfactant mixture. Especially suitable are surfactant mixtures, the Isoalkanolalkoxilate A) in an amount of 0.2 to 7 wt .-%, more particularly 0.3 to 5 wt .-%, based on the total weight of the surfactant mixture. Of the remaining part is omitted on conventional surface-active substances B). Such mixtures are particularly advantageous for formulation cosmetic and pharmaceutical agents.

• a) wenigstens ein Isoalkanolalkoxilat A), wie zuvor definiert,
• b) wenigstens einen kosmetisch oder pharmazeutisch akzeptablen Wirk- oder Effektstoff, und
• c) gegebenenfalls wenigstens einen weiteren kosmetisch oder pharmazeutisch akzeptablen Hilfsstoff.

Another object of the invention is a cosmetic or pharmaceutical agent containing

• a) at least one isoalkanol alkoxylate A), as defined above,
• b) at least one cosmetically or pharmaceutically acceptable active or effect substance, and
• c) optionally at least one further cosmetically or pharmaceutically acceptable excipient.

Preferably the components b) and c) are selected from cosmetically and / or dermatologically active substances, cosmetically acceptable carriers, emulsifiers, Surfactants, silicone compounds, cosmetically acceptable polymers, preservatives, Perfume oils, rheology modifiers (especially thickener), neutralizing agents (such as acids and Bases), hair and skin conditioners, bleaches, gelling agents, care products, colorants, Tints, Tanning agents, Dyes, pigments, antidandruff agents, sunscreens, deodorizing agents, vitamins, plant extracts, bodying agents, Humectants, restockers, Collagen, protein hydrolysates, Lipids, antioxidants, defoamers, Antistatic agents, emollients and plasticisers.

suitable cosmetically and / or dermatologically active agents b) are z. B. coloring Active ingredients, skin and hair pigmentation agents, toning agents, Tanning agents, Bleach, keratin-curing Substances, antimicrobial agents, light filter agents, repellent agents, hyperemic substances, keratolytic and keratoplastic active substances, anti-dandruff agents, antiphlogistics, keratinizing acting substances, antioxidant or radical scavengers active ingredients, skin moisturizing or moisturizing substances, moisturizing Active ingredients, antierythimatös or anti-allergic active ingredients and mixtures thereof.

Artificial skin tanning active ingredients that are suitable to the skin without natural or artificial Be radiation with UV rays to tan, z. B. dihydroxyacetone, alloxan and walnut shell extract. Suitable keratin-hardening substances are generally active ingredients, as used in antiperspirants, such as. For example, potassium aluminum sulfate, aluminum hydroxychloride, aluminum lactate, etc. Antimicrobial agents are used to destroy or inhibit their growth microorganisms and thus serve both as a preservative and as a deodorizing substance, which reduces the formation or intensity of body odor. These include z. As usual preservatives known in the art, such as p-hydroxybenzoic acid, imidazolidinyl urea, formaldehyde, sorbic acid, benzoic acid, salicylic acid, etc. Such deodorizing substances are, for. Zinc ricinoleate, triclosan, undecylenic acid alkylolamides, triethyl citrate, chlorhexidine, etc. Suitable light filtering agents are substances that absorb UV rays in the UV-B and / or UV-A range. Suitable UV filters are z. B. 2,4,6-triaryl-1,3,5-triazines in which the aryl groups may each carry at least one Substi tuenten, which is preferably selected from hydroxy, alkoxy, especially methoxy, alkoxycarbonyl, especially methoxycarbonyl and ethoxycarbonyl and mixtures from that. Also suitable are cinnamic acid esters, benzophenones, camphor derivatives and UV-blocking pigments, such as titanium dioxide, talc and zinc oxide. Suitable repellent agents are compounds capable of preventing or repelling certain animals, particularly insects, from humans. This includes z. B. 2-ethyl-1,3-hexanediol, N, N-diethyl-m-toluamide, etc. Suitable hyperemic substances which stimulate the circulation of the skin are, for. For example, essential oils such as mountain pine, lavender, rosemary, juniper berry, horse chestnut extract, birch leaf extract, hay flower extract, ethyl acetate, camphor, menthol, peppermint oil, rosemary extract, eucalyptus oil, etc. Suitable keratolytic and keratoplastic substances such. As salicylic acid, calcium thioglycolate, thioglycolic acid and its salts, sulfur, etc. Suitable antidandruff agents are, for. As sulfur, Schwefelpolyethylenglykolsorbitanmonooleat, Schwefelricinolpolyethoxylat, Zinkpyrithion, Aluminiumpyrithion, etc. Suitable antiphlogistics, which counteract skin irritation, z. As allantoin, bisabolol, Dragosantol, chamomile extract, panthenol, etc. As further ingredients may be natural or synthetic compounds, eg. For example, lanolin derivatives, cholesterol derivatives, isopropyl myristate, isopropyl palmitate, electrolytes, dyes, preservatives, acids (eg, lactic acid, citric acid) may be added.

A comprehensive description of cosmetic excipients can be found in H. P. Fiedler, Lexicon of excipients for pharmacy, cosmetics and related Areas, 4th Edition, Aulendorff: ECV Editio-Cantor-Verlag, 1996. One comprehensive presentation of basic, auxiliary and active ingredients as well as suitable formulations can be found in K. Schrader, Basics and formulations of cosmetics, 2nd edition, Hüthig-Verlag Heidelberg (1989).

suitable only slightly water-soluble or water-insoluble cosmetically acceptable carrier c) are z. B. selected under oils, Fats, waxes, saturated acyclic and cyclic hydrocarbons, fatty acids, fatty alcohols, etc. and mixtures thereof.

Suitable aqueous carriers c) are, for. B. selected from water, water-miscible organic solvents, preferably C ₁ -C ₈ -alkanols and alkanediols, and mixtures thereof. Suitable hydrophilic carriers are, for. B. selected from water, ethanol, n-propanol, iso-propanol, propylene glycol, glycerol, sorbitol, etc.

The cosmetic compositions according to the invention have z. An oil or fat component selected from: low polarity hydrocarbons such as mineral oils; linear saturated hydrocarbons, preferably having more than 8 C atoms, such as tetradecane, hexadecane, octadecane, etc .; cyclic hydrocarbons, such as decahydronaphthalene; branched hydrocarbons; animal and vegetable oils; To grow; Wax esters; Petroleum jelly; Esters, preferably esters of fatty acids, such as. The esters of C ₁ -C ₂₄ monoalcohols with C ₁ -C ₂₂ monocarboxylic acids such as isopropyl isostearate, n-propyl myristate, isopropyl myristate, n-propyl palmitate, iso-propyl palmitate, hexacosanyl palmitate, octacosanyl palmitate, triacontanyl palmitate, dotriacontanyl palmitate, tetratriacontanyl palmitate, Hexancosanyl stearate, octacosanyl stearate, triacontanyl stearate, dotriacontanyl stearate, tetratriacontanyl stearate; Salicylates such as C ₁ -C ₁₀ salicylates, e.g. Octyl salicylate; Benzoate esters such as C ₁₀ -C ₁₅ alkyl benzoates, benzyl benzoate; other cosmetic esters such as fatty acid triglycerides, propylene glycol monolaurate, polyethylene glycol monolaurate, C ₁₀ -C ₁₅ alkyl lactates, etc., and mixtures thereof.

suitable silicone oils are z. B. linear polydimethylsiloxanes, poly (methylphenylsiloxanes), cyclic siloxanes and mixtures thereof. The number average molecular weight the polydimethylsiloxanes and poly (methylphenylsiloxanes) are preferably in a range of about 1000 to 150000 g / mol. Preferred cyclic Siloxanes have 4- to 8-membered rings. Suitable cyclic Siloxanes are z. B. under the name cyclomethicone commercially available.

Preferred oil or Fat components are selected under paraffin and paraffin oils; Petroleum jelly; natural Fats and oils, like castor oil, Soybean oil, Peanut oil, Olive oil, Sunflower oil, Sesame oil, Avocado oil, Cocoa butter, almond oil, Peach kernel oil, Castor oil, Cod liver oil, lard, spermaceti, sperm oil, sperm oil, wheat germ oil, macadamia nut oil, evening primrose oil, jojoba oil; Fatty alcohols, such as lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, Oleyl alcohol, cetyl alcohol; Fatty acids, such as myristic acid, stearic acid, palmitic acid, oleic acid, linoleic acid, and linolenic acid of which various saturated, unsaturated and substituted fatty acids; Grow, such as beeswax, carnauba wax, candililla wax, spermaceti and mixtures of the aforementioned oil or fat components.

The cosmetic according to the invention and pharmaceutical agents as a cosmetic and / or pharmaceutical active substance (as well as optionally as adjuvant) at least one cosmetically or pharmaceutically acceptable Polymer included. These include generally anionic, cationic, amphoteric and neutral polymers.

Examples of anionic polymers are homo- and copolymers of acrylic acid and methacrylic acid or their salts, copolymers of acrylic acid and acrylamide and their salts; Sodium salts of polyhydroxycarboxylic acids, water-soluble or water-dispersible polyesters, polyurethanes (eg. B. Luviset PUR ^® from. BASF), and polyureas. Particularly suitable polymers are copolymers of t-butyl acrylate, ethyl acrylate, methacrylic acid (z. B. Luvimer 100P ^®), copolymers of ethyl acrylate and methacrylic acid (eg. B. Luviflex Soft ^® and Luvimer ^® MAE), copolymers of N-tert-butylacrylamide acrylate, ethyl acrylate, acrylic acid (Ultrahold ^® 8, strong of BASF AG), copolymers of vinyl acetate, crotonic acid and optionally further Vinylester (z. B. Luviset ^® brands from BASF AG), maleic anhydride copolymers, optionally reacted with alcohol, anionic polysiloxanes, eg. B. carboxy-functional, t-butyl acrylate, methacrylic acid (eg., Luviskol ^® VBM BASF AG), copolymers of acrylic acid and methacrylic acid with hydrophobic monomers, such. C ₄ -C ₃₀ alkyl esters of meth (acrylic acid), C ₄ -C ₃₀ -alkyl vinyl esters, C ₄ -C ₃₀ -alkyl vinyl ethers and hyaluronic acid. Examples of anionic polymers are also vinyl acetate / crotonic acid copolymers, such as (National Starch) and Gafset ^® (GAF) are commercially available and, for example, under the names Resyn ^® vinylpyrrolidone / vinyl acrylate copolymers, obtainable for example under the trade name Luviflex ^® (BASF) , Other suitable polymers are the VBM-35 under the name Luviflex ^® (BASF) available vinylpyrrolidone / acrylate terpolymer and sodium sulfonate-containing polyamides or sodium sulfonate-containing polyester.

/ / Octyl acrylamide acrylates butylaminoethyl methacrylate; Furthermore, the group of suitable for combination with the novel polymers exemplified polymers comprises Balance CR ^® (National Starch; Acrylate Copolymer), balance 0/55 ^® (National Starch; Acrylate Copolymer), Balance ^® 47 (National Starch copolymer) Aquaflex ^® FX 64 (ISP; isobutylene / ethylmaleimide / hydroxyethylmaleimide copolymer) Aquaflex ^® SF-40 (ISP / National Starch; VP / vinyl caprolactam / DMAPA acrylates copolymer), Alliance ^® LT-120 (ISP / Rohm &Haas; acrylates / C1-2 succinate / hydroxyacrylate copolymer), Aquarez ^® HS (Eastman, polyester-1), and ^® Diaformer Z-400 (Clariant; methacryloylethylbetaine / methacrylate copolymer), ^® Diaformer Z-711 (Clariant; methacryloylethyl N oxide / methacrylate copolymer), ^® Diaformer Z-712 (Clariant; methacryloylethyl N-oxide / methacrylate copolymer), Omnirez ^® 2000 (ISP; monoethyl ester of poly (methyl vinyl ether / maleic acid in ethanol), Amphomer ^® HC (National Starch; acrylate / Octylacrylam id copolymer), Amphomer ^® 28-4910 (National Starch; Octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer), Advantage ^® HC 37 (ISP terpolymer of vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate), Advantage ^® LC55 and LC80 or LC A and LC E, Advantage ^® Plus (ISP; VA / butyl maleate / isobornyl acrylates copolymer), Aculyne ^® 258. (Rohm &Haas; acrylate / Hydroxyesteracrylat copolymer), Luviset ^® PUR (BASF, polyurethane-1), Luviflex ^® Silk (BASF), Eastman ^® AQ 48 (Eastman), Styleze ^® CC-10 ( ISP; VP / DMAPA acrylates copolymer), Styleze® ^® 2000 (ISP; VP / acrylates / lauryl Methacrylate copolymer), Dy namX (National Starch; Polyurethane-14 AMP-acrylate copolymer), Resyn XP (National Starch; acrylates / octylacrylamide copolymer) , Fixomer A-30 (Ondeo Nalco, polymethacrylic acid (and) acrylamidomethylpropane sulfonic acid), Fixate G-100 (Noveon, AMP Acrylates / Allyl Methacrylate Copolymer).

All As anionic polymers, acrylates are particularly preferred an acid number greater or equal 120 and copolymers of t-butyl acrylate, ethyl acrylate and methacrylic acid used.

Further suitable polymers are cationic polymers with the name Polyquaternium according to INCI, z. For example, copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat ^® FC, Luviquat ^® HM, Luviquat ^® MS, Luviquat Care ^® from BASF AG), copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Luviquat ^® PQ 11 from BASF AG) , copolymers of N-vinylcaprolactam / N-vinylpyrrolidone / N-vinylimidazolium salts (Luviquat Hold ^® of BASF AG); Copolymers of N-vinylpyrrolidone / dimethylaminopropylmethacrylamide / methacryloylaminopropyllauryldimonium chloride (Polyquaternium-55), cationic Cellulose derivatives (Polyquaternium-4 and -10), acrylamidocopolymers (Polyquaternium-7) and chitosan. Suitable cationic (quaternized) polymers are also Merquat ^® (polymer based on dimethyldiallylammonium chloride), Gafquat ^® (quaternary polymers are formed by reacting polyvinylpyrrolidone with quaternary ammonium compounds), Polymer JR (hydroxyethylcellulose with cationic groups) and cationic polymers based on plants, z. As guar polymers, such as the Jaguar ^® brands Fa. Rhodia and guar hydroxypropyltrimonium chloride (INCI).

Further suitable polymers are also neutral polymers, such as polyvinylpyrrolidones, copolymers of N-vinylpyrrolidone and vinyl acetate and / or vinyl propionate, copolymers of N-vinylpyrrolidone and dimethylaminopropylacrylamide or -methacrylamide (DMAPA), copolymers of N-vinylpyrrolidone and (meth) acrylic acid esters, polysiloxanes , Polyvinylcaprolactam and other copolymers with N-vinylpyrrolidone, polyethyleneimines and their salts, polyvinylamines and their salts, cellulose derivatives, polyaspartic acid salts and derivatives. This includes, for example Luviflex® ^® Swing (partially hydrolyzed copolymer of polyvinyl acetate and polyethylene glycol, Messrs. BASF).

Suitable polymers are also nonionic, water-soluble or water-dispersible polymers or oligomers, such as polyvinyl caprolactam, z. B. Luviskol ^® Plus (BASF), or polyvinylpyrrolidone and their copolymers, in particular with vinyl esters, such as vinyl acetate, z. B. Luviskol ^® VA 37 (BASF); Polyamides, z. B. based on itaconic acid and aliphatic diamines, as z. B. in DE-A-43 33 238 are described.

Suitable polymers are also amphoteric or zwitterionic polymers, such as those available under the names Amphomer ^® (National Starch) octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers and zwitterionic polymers, as described for example in the German patent applications DE 39 29 973 . DE 21 50 557 . DE 28 17 369 and DE 37 08 451 are disclosed. Acrylamidopropyltrimethylammonium chloride / acrylic acid or methacrylic acid copolymers and their alkali metal and ammonium salts are preferred zwitterionic polymers. Further suitable zwitterionic polymers are methacroylethylbetaine / methacrylate copolymers (AMERCHOL) are commercially available under the name Amersette® ^®, and copolymers of hydroxyethyl methacrylate, methyl methacrylate, N, N-dimethylaminoethyl methacrylate and acrylic acid (Jordapon ^®).

Suitable polymers are also silicone compounds, for example polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, silicone resins and especially nonionic, siloxane-containing, water-soluble or -dispersible polymers, eg. As polyether siloxanes, such as Tegopren ^® (Goldschmidt) or Belsil ^® (Wacker). Also suitable are dimethicone copolyols (CTFA) and amino-functional silicone compounds, such as amodimethicones.

In a special version is at least one of the components b) or c) to connect with a solubility in water of below 10 g / l, in particular below 1 g / l and especially below 0.1 g / l at 25 ° C and 1013 mbar. In this case, the isoalkanol alkoxylates used according to the invention act A) as solubilizers for the poorly soluble (s) Component (s).

at the cosmetic according to the invention Means are in a special embodiment to solubilizate on water or water / alcohol base. The solubilizers to be used according to the invention A) are then preferably in proportion from 0.2: 1 to 20: 1, preferably 1: 1 to 15: 1, more preferably 2: 1 to 12: 1 to sparingly soluble cosmetic active or effect substance b) and / or auxiliary c) are used. The content of the invention to be used Solubilizer A) in the cosmetic compositions is preferably in Range of 0.01 to 50 wt .-%, preferably 0.05 to 20 wt .-%, especially preferably 0.1 to 10 wt .-%, based on the total weight of the composition.

Separate poorly water-soluble or water-insoluble Components such as UV filters, pigments, etc. are below listed. If additional to the isoalkanol alkoxides A) further surfactants are used, it is preferably a surfactant mixture according to the invention, as previously defined. On there ge called suitable and preferred Conventional surfactants are fully incorporated herein by reference. Specifically, it is z. For example, betaines, amine oxides and quaternized Nitrogen-containing polymers. Preferably, the inventive cosmetic Agent component A) or a surfactant system according to the invention in an amount from 0.01 to 30% by weight, based on the total weight of the composition, on.

Salts such as sodium chloride are preferably used in an amount of about 0.5 to 10% by weight based on the total weight of the agent. The water content can generally be varied within wide limits. Usual amounts of water are 3 to 90 wt .-%, preferably 5 to 80 wt .-%, based on the total weight of the agent. Also, the alcohol content can generally be varied within wide ranges. Usual amounts of alcohols are 0 to 95 wt .-%, preferably 0.1 to 80 wt .-%, based on the total weight of the composition. If present, cosmetic oils and waxes are preferably used in an amount of about 0.5 to 70% by weight, based on the total weight of the composition. Silicone compounds may, for. B. in an amount of 0.05 to 30 wt .-%, based on the total weight of the agent used. Suitable cosmetically acceptable polymers are, for. As nonionic, anionic, cationic or anionic polymers, especially film-forming polymers, the z. B. are used for strengthening and / or shaping of the hair. These polymers are usually used in an amount of 0.05 to 30 wt .-%, z. B. 1 to 15 wt .-%, based on the total weight of the agent used. Polymers having acidic or basic groups may, if desired, be partially or completely neutralized with a conventional neutralizing agent. Typical levels of neutralization are in a range of about 50 to 100%. To adjust the rheological properties, the agents may contain at least one rheology modifier. Suitable levels of rheology modifier are in a range of 0.01 to 50 weight percent, based on the total weight of the composition. In general, active substances and auxiliaries are present in cosmetic and dermatological compositions in an amount of about 0.005 to 95% by weight, preferably 0.01 to 50% by weight, based on the total weight of the composition. The quantities given in this paragraph refer to those commonly used in the formulation of cosmetic and dermatological products. In individual cases, the skilled person will, of course, deviate from this general information in the context of his or her knowledge of achieving a particular effect or product characteristic.

at the cosmetic according to the invention It may be z. For example, skin-cosmetic, dermatological, hair cosmetics or hygiene products, eg. For oral or dental care, act.

Preferably are the agents of the invention in the form of a gel, foam, spray, ointment, cream, emulsion, Suspension, lotion, milk or paste in front. If you wish too Liposomes or microspheres be used.

To a further preferred embodiment the agents according to the invention are a hair treatment agent.

Preferably are the hair treatment compositions according to the invention in the form of a mousse, hair mousse, hair gel, shampoo, Hair sprays, hair mousse, top fluids, perms, hair coloring and bleach or "hot oil treatments". It can these are both so-called rinse-off applications also to leave in the hair remaining applications (leave-on). ever according to application the hair cosmetic preparations as (aerosol) spray, (aerosol) foam, Gel, gel spray, cream, lotion or wax can be applied. hairsprays include both aerosol sprays and pump sprays without propellant gas. hair foams include both aerosol foams as well as pump foams without propellant. Hairsprays and hair foams preferably comprise predominantly or exclusively water-soluble or water-dispersible components. Are those in the hairsprays according to the invention and hair foams water-dispersible compounds used, they can be in the form of aqueous Microdispersions with particle diameters of usually 1 to 350 nm, preferably 1 to 250 nm, are used. The solids content of these preparations usually lie here in a range of about 0.5 to 20 wt%. These microdispersions need usually no emulsifiers or surfactants for their stabilization.

The hair cosmetic according to the invention Formulations contain preferably as formulation base Water or water-alcohol mixtures. Under alcohol are all in the usual cosmetics To understand alcohols, for. For example, ethanol, isopropanol, n-propanol.

suitable other ingredients are the usual additives in cosmetics, such as propellants, defoamers, surface-active Compounds, d. H. Surfactants, emulsifiers, foaming agents and solubilizers. The used surface-active Connections can anionic, cationic, amphoteric or neutral. Other common ingredients can also be z. Preservatives, perfume oils, opacifiers, active ingredients, UV filters, Nursing substances such as panthenol, collagen, vitamins, protein hydrolysates, Alpha and beta hydroxycarboxylic acids, protein hydrolysates, Stabilizers, pH regulators, dyes, viscosity regulators, Gelling agents, dyes, salts, humectants, moisturizers, Complexing agent and other common Additives.

Furthermore, this includes all known in cosmetics styling and conditioner polymers, which can be used in combination with the polymers of the invention, if very special properties are to be set. On the previously listed cationic, anionic, neutral, nonionic and amphoteric polymers are referred to in this regard.

to Setting certain properties, the preparations may also be Contain conditioning substances based on silicone compounds. Suitable silicone compounds are, for example, polyalkylsiloxanes, Polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes, silicone resins or dimethicone copolyols (CTFA) and amino functional silicone compounds like amodimethicones (CTFA).

• a) 0,05 bis 10 Gew.-% wenigstens eines kosmetisch akzeptablen Polymers,
• b) 25 bis 94,95 Gew.-% Wasser,
• c) 5 bis 50 Gew.-% wenigstens eines Isoalkanolalkoxilats A) oder eines darauf basierenden erfindungsgemäßen Tensidgemischs,
• c) 0 bis 5 Gew.-% eines weiteren Konditioniermittels,
• d) 0 bis 10 Gew.-% weitere kosmetische Bestandteile.

The isoalkanol alkoxilates A) according to the invention and surfactant mixtures based thereon according to the invention are preferably used in shampoo and shower gel formulations. Preferred shampoo and shower gel formulations contain:

• a) 0.05 to 10% by weight of at least one cosmetically acceptable polymer,
• b) from 25 to 94.95% by weight of water,
• c) from 5 to 50% by weight of at least one isoalkanol alkoxylate A) or of a surfactant mixture based thereon according to the invention,
• c) 0 to 5% by weight of a further conditioning agent,
• d) 0 to 10 wt .-% further cosmetic ingredients.

In the shampoo formulations as additional Surfactants to the Isoalkanolalkoxilaten A) all in shampoos usually used anionic, neutral, amphoteric or cationic Surfactants are used.

preferred anionic surfactants for Shampoo and shower gel formulations are, for example, alkyl sulfates, Alkyl ether sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, Alkyl sulfosuccinates, N-alkoyl sarcosinates, acyl taurates, acyl isothionates, Alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, alpha olefin sulfonates, in particular the alkali and alkaline earth metal salts, e.g. Sodium, Potassium, magnesium, calcium, as well as ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can between 1 to 10 ethylene oxide or propylene oxide units, preferred 1 to 3 ethylene oxide units in the molecule.

Suitable For example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, Ammonium lauryl ether sulfate, sodium lauroyl sarcosinate, sodium oleyl succinate, Ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate, triethanolamine dodecylbenzene sulfonate.

suitable amphoteric surfactants for Shampoo and shower gel formulations are, for example, alkyl betaines, Alkylamidopropylbetaines, alkylsulfobetaines, alkylglycinates, alkylcarboxyglycinates, Alkyl amphoacetates or propionates, alkyl amphodiacetates or dipropionates.

For example can Cocodimethyl sulphopropyl betaine, lauryl betaine, cocamidopropyl betaine or sodium cocamphopropionate.

When nonionic surfactants for For example, shampoo and shower gel formulations are suitable the reaction products of aliphatic alcohols or alkylphenols with 6 to 20 carbon atoms in the alkyl chain, which are linear or branched may be with ethylene oxide and / or propylene oxide. The amount of alkylene oxide is about 6 to 60 moles per one mole of alcohol. Furthermore, alkylamine oxides, Mono- or dialkylalkanolamides, fatty acid esters of polyethylene glycols, Alkyl polyglycosides or sorbitan ether suitable.

In addition, the Shampoo and Shower Gel Formulations Common cationic surfactants included, such as B. quaternary Ammonium compounds, for example cetyltrimethylammonium chloride.

In the shampoo and shower gel formulations conventional conditioning agents can be used to achieve certain effects. These include, for example, the aforementioned cationic polymers having the INCI name Polyquaternium, in particular copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat ^® FC, Luviquat ^® HM, Luviquat ^® MS, Luviquat ^® Care), copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Luviquat ^® PQ 11), copolymers of N-vinylcaprolactam / N-vinylpyrrolidone / N-vinylimidazolium salts (Luviquat Hold ^®); cationic cellulose derivatives (Polyquaternium-4 and -10), acrylamide copolymers (Polyquaternium-7). Furthermore, protein hydrolysates can be used, as well as conditioning substances based on silicone compounds, for example polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes or silicone resins. Other suitable silicone compounds are dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA). Furthermore, cationic guar derivatives such as guar hydroxypropyltrimonium chloride (INCI) be used.

The Isoalkanolalkoxilates according to the invention A) and based thereon surfactant mixtures according to the invention can continue in hairstyling preparations, in particular hair sprays (aerosol sprays and pump sprays without propellant gas) and hair foams (aerosol foams and pump foams without propellant gas).

• a) 0,1 bis 10 Gew.-% wenigstens eines kosmetisch akzeptablen Polymers,
• b) 20 bis 99,8 Gew.-% Wasser und/oder Alkohol,
• c) 0 bis 70 Gew.-% wenigstens eines Treibmittel,
• d) 0,1 bis 5 Gew.-% wenigstens eines Isoalkanolalkoxilats A) oder eines darauf basierenden erfindungsgemäßen Tensidgemischs,
• d) 0 bis 20 Gew.-% weitere Bestandteile

In a preferred embodiment, these preparations contain

• a) 0.1 to 10% by weight of at least one cosmetically acceptable polymer,
• b) from 20 to 99.8% by weight of water and / or alcohol,
• c) 0 to 70% by weight of at least one blowing agent,
• d) from 0.1 to 5% by weight of at least one isoalkanol alkoxylate A) or a surfactant mixture based thereon according to the invention,
• d) 0 to 20 wt .-% further ingredients

propellant are the for Hairsprays or aerosol foams commonly used Propellant. Preference is given to mixtures of propane / butane, pentane, dimethyl ether, 1,1-difluoroethane (HFC-152a), carbon dioxide, nitrogen or compressed air.

• a) 0,1 bis 10 Gew.-% wenigstens eines kosmetisch akzeptablen Polymers,
• b) 55 bis 99,8 Gew.-% Wasser und/oder Alkohol,
• c) 5 bis 20 Gew.-% eines Treibmittel,
• d) 0,1 bis 5 Gew.-% wenigstens eines Isoalkanolalkoxilats A) oder eines darauf basierenden erfindungsgemäßen Tensidgemischs,
• e) 0 bis 10 Gew.-% weitere Bestandteile.

A preferred formulation for aerosol hair foams according to the invention

• a) 0.1 to 10% by weight of at least one cosmetically acceptable polymer,
• b) 55 to 99.8% by weight of water and / or alcohol,
• c) 5 to 20% by weight of a blowing agent,
• d) from 0.1 to 5% by weight of at least one isoalkanol alkoxylate A) or a surfactant mixture based thereon according to the invention,
• e) 0 to 10 wt .-% of further ingredients.

When Emulsifiers can as additional Surfactants to the Isoalkanolalkoxilaten A) all in hair foams usually used emulsifiers are used. Suitable emulsifiers can nonionic, cationic or anionic or amphoteric.

Examples for nonionic Emulsifiers (INCI nomenclature) are Laurethe, z. Laureth-4; Cetethe, z. Cetheth-1, polyethylene glycol cetyl ether; Cetearethe, z. Cetheareth-25, Polyglycol fatty acid glycerides, hydroxylated Lecithin, lactyl ester of fatty acids, Alkylpolyglycosides.

Examples for cationic Emulsifiers are cetyldimethyl-2-hydroxyethylammonium dihydrogen phosphate, Cetyltrimonium chloride, cetyltrimmonium bromide, cocotrimonium methylsulfate, Quaternium-1 to x (INCI).

anionic Emulsifiers can for example, selected are selected from the group of alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, Alkylarylsulfonates, alkylsuccinates, alkylsulfosuccinates, N-alkoylsarcosinates, acyltaurates, Acyl isothionates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, Alpha olefin sulfonates, in particular the alkali and alkaline earth metal salts, z. As sodium, potassium, magnesium, calcium, and ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can be used between 1 to 10 ethylene oxide or propylene oxide units, preferably 1 to 3 ethylene oxide units in the molecule exhibit.

• a) 0,1 bis 10 Gew.-% wenigstens eines kosmetisch akzeptablen Polymers,
• b) 60 bis 99,75 Gew.-% Wasser und/oder Alkohol,
• c) 0,05 bis 10 Gew.-% eines Gelbildners,
• e) 0,1 bis 5 Gew.-% wenigstens eines Isoalkanolalkoxilats A) oder eines darauf basierenden erfindungsgemäßen Tensidgemischs,
• d) 0 bis 20 Gew.-% weitere Bestandteile.

A preparation suitable for styling gels according to the invention can be composed, for example, as follows:

• a) 0.1 to 10% by weight of at least one cosmetically acceptable polymer,
• b) 60 to 99.75% by weight of water and / or alcohol,
• c) 0.05 to 10% by weight of a gelling agent,
• e) from 0.1 to 5% by weight of at least one isoalkanol alkoxylate A) or a surfactant mixture based thereon according to the invention,
• d) 0 to 20 wt .-% further ingredients.

As gel formers, all gel formers customary in cosmetics can be used. These include slightly crosslinked polyacrylic acid, for example carbomer (INCI), cellulose derivatives, eg. Hydroxypropyl cellulose, hydroxyethyl cellulose, cationic modified celluloses, polysaccharides, e.g. B. Xanthum Gum, Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer, Polyquaternium-32 (and) Paraffinum Liquidum (INCI), Sodium Acrylate Copolymer (and) Paraffin Liquidum (and) PPG-1 Trideceth-6, Acrylamidopropyl Trimonium Chlo ride / Acrylamide Copolymer, Steareth-10 Allyl Ether Acrylates Copolymer, Polyquaternium-37 (and) Paraffinum Liquidum (and) PPG-1 Trideceth-6, Polyquaternium 37 (and) Propylene Glycols Dicaprate Dicaprylate (and) PPG-1 Trideceth-6, Polyquaternium-7, Polyquaternium-44.

The used according to the invention Isoalkanolalkoxilate I) and based thereon surfactant mixtures according to the invention are also advantageous for use in skin and cosmetic dermatological preparations.

To a preferred embodiment the agents according to the invention are a skin cleanser.

preferred Skin cleansers are soaps of liquid to gel consistency, like transparent soaps, luxury soaps, de-icing soaps, cream soaps, baby soaps, Skin protection soaps, abrasive soaps and syndets, pasteurized soaps, soft soaps and washing pastes, liquid Washing, shower and bath preparations, like washing lotions, shower baths and gels, bubble baths, oil baths (e.g. B. with nourishing oils, Aromatic oils, essential oils etc.) and scrub preparations, shaving foams, lotions and creams.

To a further preferred embodiment If the agents according to the invention are cosmetic Means for the care and protection of the skin, nail care preparations or Preparations for the decorative cosmetics.

suitable Skin cosmetics are z. For example, facewash, face masks, deodorants and other cosmetic lotions. Means for use in the decorative Cosmetics include, for example, concealers, theatrical paints, mascara and eyeshadows, lipsticks, kohl pencils, eyeliners, rouges, powders and eyebrow pencils.

In addition, the Isoalkanolalkoxilate A) can be used in Nose Strips for pore cleansing, in antacids, repellents, shaving products, depilatories, Intimate products, foot care products as well as in baby care.

at the skin care agents according to the invention These are in particular W / O or O / W skin creams, day and night creams, Eye creams, face creams, anti-wrinkle creams, moisturizing creams, Bleaching creams, vitamin creams, skin lotions, body lotions and moisturizing lotions.

skin cosmetic and dermatological agents preferably contain at least one Isoalkanolalkoxilate A) or a surfactant mixture according to the invention in one Proportion of about 0.01 to 30% by weight, preferably 0.05 to 20% by weight, most preferably 0.1 to 10 wt .-%, based on the total weight of Agent.

ever according to application the agents according to the invention in a form suitable for skin care, such. B. as a cream, foam, Gel, pen, mousse, milk, spray (pump spray or propellant spray) or lotion.

The skin cosmetic preparations in addition to the isoalkanol alkoxides A) or the surfactant mixtures according to the invention other active substances and auxiliaries customary in skin cosmetics, as previously described. These include preferably emulsifiers, Preservatives, perfume oils, cosmetic Active ingredients such as phytantriol, vitamins A, E and C, retinol, bisabolol, Panthenol, sunscreen, bleach, dye, tinting agent, Tanning agents, Collagen, protein hydrolysates, Stabilizers, pH regulators, dyes, salts, thickeners, Gel former, bodying agent, silicones, humectants, moisturizers and more usual ones Additives.

suitable solvent are in particular water and mono- and polyols having 1 to 8 carbon atoms, such as ethanol, isopropanol, propylene glycol, glycerol and sorbitol.

Preferred oil and fat components of the skin cosmetic and dermatological agents are the aforementioned mineral and synthetic oils, such as. As paraffins, silicone oils and aliphatic hydrocarbons having more than 8 carbon atoms, animal and vegetable oils, such as. As sunflower oil, coconut oil, avocado oil, olive oil, lanolin, babassu, or waxes, fatty acids, fatty acid esters, such as. B. triglycerides of C ₆ -C ₃₀ fatty acids, wax esters, such as. As jojoba oil, fatty alcohols, Vaseline, hydrogenated lanolin and acetylated lanolin and mixtures thereof.

In a special version the isoalkanol alkoxilates A) in combination with at least an essential oil used. Under ethereal oils are understood in general scented substances by physical Processes (eg distillative processes) from plants, plant parts or spices won can be. These are z. For example, alcohols, aldehydes, ketones, esters, Lactones, sulfur and Nitrogen-containing compounds, hydrocarbons and (partially complex) mixtures thereof. Suitable essential oils are, for. Angelica root oil, calamus oil, lavender oil, pine needle oil, juniper berry oil, cinnamon oil, hop oil, aniseed oil, peppermint oil, thyme oil, orange oil, lemon oil, rosemary oil, etc. The compositions can then z. In the form of an oil bath, Shower baths, bubble baths, gels (eg shower gels, massage gels, relaxing sports gels), Pen, a toothpaste, mouthwash etc. are available.

to Setting certain properties such. B. improvement of feel to the touch, the spreading behavior, the water resistance and / or the binding of Active ingredients and excipients, such as pigments, can be used in skin and cosmetic dermatological preparations additionally also conditioning Contain substances based on silicone compounds. suitable Silicone compounds are, for example, polyalkylsiloxanes, polyarylsiloxanes, Polyarylalkylsiloxanes, polyethersiloxanes or silicone resins. Suitable are also blends with the ones described above and those in the EP-A-1 064 924.

Common thickener in such formulations are crosslinked polyacrylic acid and their derivatives, polysaccharides such as xanthan gum, agar-agar, alginates or tyloses, carboxymethylcellulose or hydroxymethylcellulose, Fatty alcohols, monoglycerides and fatty acids, polyvinyl alcohol and Polyvinylpyrrolidone.

The Production of cosmetic or dermatological preparations takes place according to usual, known to those skilled in the process.

Prefers are the cosmetic and dermatological means in the form of Emulsions, in particular as water-in-oil (W / O) or oil-in-water (O / W) emulsions in front. But it is also possible to choose other types of formulations, for example, hydrodispersions, gels, oils, oleogels, multiple emulsions, for example in the form of W / O / W or O / W / O emulsions, anhydrous Ointments or ointment bases, etc.

The Emulsions are prepared by known methods. The Emulsions contain in addition to the Isoalkanolalkoxilat A) or a surfactant mixtures based thereon, usually conventional constituents, such as fatty alcohols, fatty acid ester and in particular fatty acid triglycerides, fatty acids, Lanolin and derivatives thereof, natural or synthetic oils or waxes and emulsifiers in the presence of water. The selection of Emulsion type specific additives and the preparation of suitable emulsions is described, for example in Schrader, basics and recipes of cosmetics, Hüthig book Verlag, Heidelberg, 2nd edition, 1989, third part, which hereby expressly Reference is made.

A suitable emulsion, for. For example a skin cream, etc., contains generally an aqueous one Phase, by means of a suitable emulsifier in an oil or Fat phase is emulsified.

The proportion of the emulsifier system in this type of emulsion is preferably about 4 and 35% by weight, based on the total weight of the emulsion. Preferably, the proportion of the fatty phase is about 20 to 60 wt .-%. Preferably, the proportion of the aqueous phase about 20 and 70%, each based on the total weight of the emulsion. The emulsifiers are those commonly used in this type of emulsion. They are z. B. selected from: C ₁₂ -C ₁₈ sorbitan fatty acid esters; Esters of hydroxystearic acid and C ₁₂ -C ₃₀ fatty alcohols; Monoesters and diesters of C ₁₂ -C ₁₈ fatty acids and glycerol or polyglycerol; Condensates of ethylene oxide and propylene glycols; oxypropylenated / oxyethylated C ₁₂ -C ₁₈ fatty alcohols; polycyclic alcohols, such as sterols; high molecular weight aliphatic alcohols such as lanolin; Mixtures of oxypropylenated / polyglycerinated alcohols and magnesium isostearate; Succinic esters of polyoxyethylenated or polyoxypropylenated fatty alcohols; and mixtures of magnesium, calcium, lithium, zinc or aluminum lanolate and hydrogenated lanolin or lanolin alcohol.

preferred Fat components which are contained in the fatty phase of the emulsions could be, are: hydrocarbon oils, like paraffin oil, purCellin, Perhydrosqualene and solutions microcrystalline waxes in these oils; animal or vegetable oils, such as sweet almond oil, avocado oil, calophilum oil, lanolin and derivatives thereof, castor oil, Sesame oil, Olive oil, jojoba oil, Shea oil, Hoplostethus oil; mineral oils, The beginning of distillation under atmospheric pressure at about 250 ° C and their Distillation endpoint at 410 ° C lies, such. Vaseline oil; Saturated esters or unsaturated fatty acids, such as alkyl myristates, e.g. B. i-propyl, butyl or cetyl myristate, Hexadecyl stearate, ethyl or i-propyl palmitate, octanoic or decanoic acid triglycerides and cetyl ricinoleate.

The Fat phase can also be found in other oils soluble Silicone oils, such as dimethylpolysiloxane, methylphenylpolysiloxane and the silicone glycol copolymer, fatty acids and fatty alcohols.

Around the retention of oils to favor, can also waxes are used, such as. Carnauba wax, candililla wax, Beeswax, microcrystalline wax, ozokerite wax and Ca, Mg and Al oleates, myristates, linoleates and stearates.

in the Generally, the water-in-oil emulsions are prepared that the fat phase and the emulsifier are placed in a mixing container become. You warm up this at a temperature of about 50 to 75 ° C, then gives the oil-soluble Active ingredients and / or adjuvants and added with stirring to water, which was previously heated to about the same temperature and wherein optionally the water-soluble Ingredients solved before Has. One stirs, until you get an emulsion of the desired Fineness receives and lets then cool to room temperature, optionally with less stirring becomes.

Farther may be a care emulsion according to the invention as O / W emulsion. Such an emulsion usually contains an oil phase, Emulsifiers, the oil phase in the water phase stabilize, and an aqueous Phase, usually thickened present.

• – Alkohole, Diole oder Polyole sowie deren Ether, vorzugsweise Ethanol, Isopropanol, Propylenglycol, Glycerin, Ethylenglycolmonoethylether;
• – übliche Verdickungsmittel bzw. Gelbildner, wie z. B. vernetzte Polyacrylsäuren und deren Derivate, Polysaccharide wie Xanthan Gum oder Alginate, Carboxymethylcellulose oder Hydroxycarboxymethylcellulose, Fettalkohole, Polyvinylalkohol und Polyvinylpyrrolidon.

The aqueous phase of the O / W emulsion of the preparations according to the invention optionally contains:

• - Alcohols, diols or polyols and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol monoethyl ether;
• - usual thickeners or gel formers, such as. As crosslinked polyacrylic acids and their derivatives, polysaccharides such as xanthan gum or alginates, carboxymethylcellulose or hydroxycarboxymethylcellulose, fatty alcohols, polyvinyl alcohol and polyvinylpyrrolidone.

• – Ester aus gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkancarbonsäuren und gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkoholen, aus aromatischen Carbonsäuren und gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkoholen, beispielhaft Isopropylmyristat, Isopropylstearat, Hexyldecylstearat, Oleyloleat; außerdem synthetische, halbsynthetische und natürliche Gemische solcher Ester, wie Jojobaöl;
• – verzweigte und/oder unverzweigte Kohlenwasserstoffe und -wachse;
• – Siliconöle wie Cyclomethicon, Dimethylpolysiloxan, Diethylpolysiloxan, Octamethylcyclotetrasiloxan sowie Mischungen daraus;
• – Dialkylether;
• – Mineralöle und Mineralwachse;
• – Triglyceride gesättigter und/oder ungesättigter, verzweigter und/oder unverzweigter C₈-C₂₄-Alkancarbonsäuren; sie können ausgewählt werden aus synthetischen, halbsynthetischen oder natürlichen Ölen, wie Olivenöl, Palmöl, Mandelöl oder Mischungen.

The oil phase contains in cosmetics conventional oil components, such as:

• Esters of saturated and / or unsaturated, branched and / or unbranched C ₃ -C ₃₀ -alkanecarboxylic acids and saturated and / or unsaturated, branched and / or unbranched C ₃ -C ₃₀ -alcohols, of aromatic carboxylic acids and saturated and / or unsaturated branched and / or unbranched C ₃ -C ₃₀ -alcohols, for example isopropyl myristate, isopropyl stearate, hexyldecyl stearate, oleyl oleate; also synthetic, semi-synthetic and natural mixtures of such esters as jojoba oil;
• - branched and / or unbranched hydrocarbons and waxes;
• Silicone oils such as cyclomethicone, dimethylpolysiloxane, diethylpolysiloxane, octamethylcyclotetrasiloxane and mixtures thereof;
• - dialkyl ethers;
• - mineral oils and mineral waxes;
• Triglycerides of saturated and / or unsaturated, branched and / or unbranched C ₈ -C ₂₄ -alkanecarboxylic acids; they can be selected from synthetic, semi-synthetic or natural oils, such as olive oil, palm oil, almond oil or mixtures.

When Emulsifiers are preferably O / W emulsifiers, such as polyglycerol esters, Sorbitan esters or partially esterified glycerides.

The Production can be carried out by melting the oil phase at about 80 ° C; the water-soluble Ingredients become in hot Solved water, slowly and with stirring to the oil phase added; homogenized and cold-stirred.

To a further preferred embodiment if the agents according to the invention are a washing or Shower gel, a shampoo formulation or a bathing preparation.

Such Formulations preferably contain a surfactant mixture according to the invention with for such formulations usually used anionic surfactants as base surfactants and more amphoteric and / or nonionic surfactants as cosurfactants. Further suitable active ingredients and / or auxiliaries are generally selected from Lipids, perfume oils, dyes, organic acids, Preservatives and antioxidants as well as thickeners / gelling agents, Skin conditioners and moisturizers.

These Formulations preferably contain from 2 to 50% by weight, preferably 5 to 40 wt .-%, particularly preferably 8 to 30 wt .-% surfactants, based on the total weight of the formulation.

In the washing, shower and bath preparations can all in body cleansers usually used anionic, neutral, amphoteric or cationic surfactants used as described above.

The Formulation basis of the pharmaceutical compositions according to the invention contains preferably pharmaceutically acceptable excipients. pharmaceutical acceptable in the field of pharmacy, food technology and adjacent areas of known adjuvants, in particular those in relevant pharmacopoeia (eg DAB Ph. Eur. BP NF) and other excipients, whose properties do not conflict with a physiological application.

suitable Excipients can be: lubricants, wetting agents, emulsifying and suspending agents, preservatives Agents, anti-oxidants, anti-irritants, chelating agents, emulsion stabilizers, Film formers, gelling agents, odor masking agents, resins, hydrocolloids, Solvents Solubilizers, Neutralizing agents, permeation enhancers, pigments, quaternary ammonium compounds, refatting and superfatting agents, Ointment, cream or oil bases, Silicone derivatives, stabilizers, sterilants, blowing agents, drying agents, Opacifiers, Thickeners, waxes, softeners, white oils. A related embodiment based on expert Knowledge, as for example in Fiedler, H. P. Encyclopedia of excipients for pharmacy, Cosmetics and adjacent areas, 4th ed., Aulendorf: ECV Editio Kantor Verlag, 1996, shown are.

to Production of dermatological according to the invention Means can the active ingredients mixed with a suitable excipient (excipient) or diluted become. Excipients can solid, semi-solid or liquid Be materials that act as a vehicle, carrier or medium for the drug can serve. If desired, the admixing of further auxiliaries takes place in the person skilled in the art known way. In particular, these are aqueous solutions or Solubilisates for oral or parenteral administration. Furthermore are suitable the invention to be used Copolymers also for use in oral dosage forms such as tablets, Capsules, powders, solutions. here we can You the sparingly soluble Drug with an elevated bioavailability to disposal put. In parenteral administration, in addition to solubilisates also Emulsions, for example, fat emulsions are used. Also For this Purpose of the copolymers of the invention are poorly soluble To process drug.

pharmaceutical Formulations of the above kind can be prepared by processing the to be used according to the invention Isoalkanolalkoxilate A) with pharmaceutical agents according to conventional Methods and using known and new agents obtained become.

The use according to the invention can additionally pharmaceutical excipients and / or diluents. When Excipients are cosolvents, stabilizers, preservatives especially listed.

in principle are the inventively used Isoalkanolalkoxilate A) for the use with any pharmaceutical active ingredients. Prefers the active pharmaceutical ingredients used are insoluble in water or little soluble Substances. The isoalkanol alkoxylates A) then serve advantageously as solubilizers for these agents. According to DAB 9 (German Pharmacopoeia) the solubility is graded pharmaceutical active ingredients as follows: sparingly soluble (soluble in 30 to 100 parts Solvent); poorly soluble (soluble in 100 to 1000 parts of solvent); practically insoluble (soluble in more than 10,000 parts of solvent). The active ingredients can come from every indication.

Especially those of the abovementioned pharmaceutical agents are preferably those which are parenterally administrable formulations.

Of the Content of inventive solubilizer in the pharmaceutical agents, depending on the active ingredient, in the field from 0.01 to 50 wt .-%, preferably 0.1 to 40 wt .-%, particularly preferably 1 to 30 wt .-%, based on the total weight of the composition.

In principle, all pharmaceutical active ingredients and prodrugs are suitable for the production of the pharmaceutical agents according to the invention. These include benzodiazepines, antihypertensives, vitamins, cytostatic drugs-especially taxol, anesthetics, neuroleptics, antidepressants, antibiotics, antifungals, fungicides, chemotherapeutics, urologics, platelet aggregation inhibitors, sulfonamides, spasmolytics, hormones, immunoglobulins, serums, thyroid medicines, psychotropic drugs, Parkinson's drugs and other antihyperkinetics, Ophthalmics, neuropathy preparations, calcium metabolism regulators, muscle relaxants, anesthetics, Lipid-lowering agents, liver therapeutics, coronary agents, cardiac drugs, immunotherapeutics, regulatory peptides and their inhibitors, hypnotics, sedatives, gynecologics, gout, fibrinolytics, enzyme preparations and transport proteins, enzyme inhibitors, emetics, circulation-enhancing agents, diuretics, diagnostics, corticoids, cholinergics, bile ducts, antiasthmatics, broncholytics , Beta-blockers, calcium antagonists, ACE inhibitors, atherosclerosis agents, antiphlogistics, anticoagulants, antihypotonics, antihypoglycemics, antihypertensives, antifibrinolytics, antiepileptics, antiemetics, antidotes, antidiabetics, antiarrhythmics, antianemics, antiallergics, anthelmintics, analgesics, analeptics, aldosterone antagonists, weight loss agents. Examples of suitable active pharmaceutical ingredients are in particular the active substances mentioned in paragraphs 0105 to 0131 of US 2003/0157170.

• – wenigstens ein Isoalkanolalkoxilat A), wie zuvor definiert, und
• – wenigstens einen Wirk- oder Effektstoff, der in Wasser bei 25°C und 1013 mbar eine Löslichkeit unterhalb 10 g/l aufweist.

The isoalkanol alkoxylates used according to the invention are advantageously suitable as emulsifiers or solubilizers of active substances or effect substances which are insoluble or only sparingly soluble in water. Another object of the invention is therefore an active or effect composition containing

• At least one isoalkanol alkoxylate A) as defined above, and
• - At least one active or effect substance which has a solubility in water at 25 ° C and 1013 mbar below 10 g / l.

In a suitable embodiment when the compositions according to the invention are aqueous compositions, the one watery Medium as a continuous phase and at least one in the continuous Phase solubilized or dispersed drug and / or effect substance include.

The used according to the invention Isoalkanolalkoxilat A) can in mixture or in combination with other surface-active Substances, such. As anionic, cationic, zwitterionic or nonionic surfactants or wetting agents. Preferably, they then come in the form of a surfactant mixture according to the invention, as previously described, are used.

Prefers can the isoalkanol alkoxilates A) as solubilizers for in water slightly soluble or insoluble UV absorbers are used.

Of the Term UV absorber encompasses in the context of the present invention UV-A, UV-B and / or Broadband filter.

wobei R¹, R⁸ und R⁹ unabhängig voneinander gewählt werden aus der Gruppe der verzweigten und unverzweigten Alkylgruppen mit 1 bis 10 Kohlenstoffatomen bzw. ein einzelnes Wasserstoffatom darstellen. Insbesondere bevorzugt sind das 2,4-Bis-{[4-(2-Ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCI: Aniso Triazin), welches unter der Handelsbezeichnung Tinosorb^® S bei der CIBA-Chemikalien GmbH erhältlich ist.Advantageous broadband filters, UV-A or UV-B filter substances are, for example, representatives of the following classes of compounds: bis-resorcinyl triazine derivatives having the following structure:

wherein R ¹ , R ⁸ and R ^{9 are} independently selected from the group of branched and unbranched alkyl groups having 1 to 10 carbon atoms or represent a single hydrogen atom. Especially preferred are 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: aniso triazine), which CIBA-Chemikalien GmbH is available under the trade name Tinosorb ^® S in.

aufweisen, sind vorteilhafte UV-Filtersubstanzen im Sinne der vorliegenden Erfindung, beispielsweise die in der Europäischen Offenlegungsschrift EP 570 838 A1 beschriebenen s-Triazinderivate, deren chemische Struktur durch die generische Formel

wiedergegeben wird, wobei
R¹³ einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, darstellt,
Z ein Sauerstoffatom oder eine NH-Gruppe darstellt,
R¹⁴ einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher
A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
R¹⁶ ein Wasserstoffatom oder eine Methylgruppe darstellt,
n eine Zahl von 1 bis 10 darstellt,
R¹⁵ einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, darstellt, wenn X die NH-Gruppe darstellt, und einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher
A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
R¹⁶ ein Wasserstoffatom oder eine Methylgruppe darstellt,
n eine Zahl von 1 bis 10 darstellt,
wenn X ein Sauerstoffatom darstellt.Other UV filter substances, which are the structural motif

have advantageous UV filter substances in the sense of the present invention, for example, those in the European published patent application EP 570 838 A1 described s-triazine derivatives, their chemical structure by the generic formula

is reproduced, wherein
R ^{13 is} a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
Z represents an oxygen atom or an NH group,
R ^{14 is} a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted with one or more C ₁ -C ₄ alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R ^{16 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
R ^{15 is} a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted with one or more C ₁ -C ₄ alkyl groups, when X represents the NH group, and a branched one or straight-chain C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical optionally substituted by one or more C ₁ -C ₄ -alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R ^{16 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
when X represents an oxygen atom.

wiedergegeben wird, welches im Folgenden auch als Dioctylbutylamidotriazon (INCI: Diethylhexylbutamidotriazone) bezeichnet wird und unter der Handelsbezeichnung UVASORB^® HEB bei Sigma 3V erhältlich ist.Particularly preferred UV filter substance in the context of the present invention is also an unsymmetrically substituted s-triazine whose chemical structure is represented by the formula

which is also referred to below as Dioctylbutylamidotriazon (INCI: Diethylhexylbutamidotriazone) and under the trade name UVASORB ^® HEB available from Sigma 3V.

Also advantageous for the purposes of the present invention is a symmetrically substituted s-triazine, the 4,4 ', 4''- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2 ethylhexyl ester), synonym: 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: ethylhexyl triazone), which was obtained from BASF Aktiengesellschaft is marketed under the trade name Uvinul ^® T 150th

wiedergegeben wird, wobei R¹⁷ und R¹⁸ u. a. C₃-C₁₈-Alkyl oder C₂-C₁₈-Alkenyl und A₁ einen aromatischen Rest repräsentieren.Also in the European patent application 775,698 preferred bis-Resorcinyltriazinderivate be described whose chemical structure by the generic formula

where R ¹⁷ and R ^{18 are,} inter alia, C ₃ -C ₁₈ -alkyl or C ₂ -C ₁₈ -alkenyl and A _{1 is} an aromatic radical.

Advantageous For the purposes of the present invention are also the 2,4-bis - {[4- (3-sulfonato) -2-hydroxy-propyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3 , 5-triazine Sodium salt, 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine . 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- [4- (2-methoxyethylcarboxyl) -phenylamino] -1,3,5-triazine . 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- [4- (2-ethylcarboxyl) -phenylamino] 1,3,5-triazine, 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (1-methylpyrrol-2-yl) -1,3,5-triazine 2,4-bis - {[4-tris (trimethylsiloxy-silylpropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, 2,4-bis - {[4- (2 '' - methylpropenyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine and 2,4-bis - {[4- (1 ', 1', 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy-2 "-methyl-propyloxy) -2-hydroxy] - phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine.

Advantageous oil-soluble UV-B and / or broadband filter substances are, for. B .:
3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
4-aminobenzoic acid derivatives, preferably (2-ethylhexyl) (4-dimethylamino) benzoate, 4-dimethylamino) benzoic acid;
Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone (under the trade name Uvinul ^® M40 from the Fa. BASF available) 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone (available under the trade name Uvinul ^® D 50 from the Fa. BASF).

Especially advantageous at room temperature liquid UV filter substances in For the purposes of the present invention, homomenthylsalicylate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-ethylhexyl 2-hydroxybenzoate and esters of cinnamic acid, preferably 4-methoxycinnamate (2-ethylhexyl) ester and 4-methoxycinnamic acid isopentyl ester.

Homomethylsalicylate (INCI: Homosalate) is characterized by the following structure:

2-ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI: Octocrylene) is available from BASF under the name Uvinul ^® N 539T and is characterized by the following structure:

2-ethylhexyl-2-hydroxybenzoate (2-ethylhexyl salicylate, octyl salicylate, INCI: Ethylhexyl Salicylate) is available, for example, from Haarmann & Reimer under the trade name Neo Heliopan OS ^® and is characterized by the following structure:

4-methoxycinnamate (2-ethylhexyl) ester: BASF (2-ethylhexyl 4-methoxycinnamate, INCI Ethylhexyl Methoxycinnamate) is available, for example at the company under the trade name Uvinul ^® MC 80 and is characterized by the following structure.:

4-methoxycinnamate (isopentyl 4-methoxycinnamate, INCI: Isoamyl p-Methoxycinnamate) is available, for example, from Haarmann & Reimer under the drawing Handelsbe Neo Heliopan E 1000 and ^® is characterized by the following structure:

Advantageous dibenzoylmethane derivatives according to the present invention, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS-Nr. 70356-09-1), marketed by BASF under the trademark Uvinul ^® BMBM and from Merck under the trade name Eusolex ^® sold 9020 is characterized by the following structure:

Another advantageous dibenzoylmethane derivative is 4-isopropyl-dibenzoylmethane (CAS no. 63250-25-9), which is sold by Merck under the name Eusolex ^® 8020th The Eusolex 8020 is characterized by the following structure:

worin
R¹⁹ und R²⁰ unabhängig voneinander lineare oder verzweigte, gesättigte oder ungesättigte, substituierte (z. B. mit einem Phenylrest substituierte) oder unsubstituierte Alkylreste mit 1 bis 18 Kohlenstoffatomen stehen.Benzotriazoles are characterized by the following structural formula:

wherein
R ¹⁹ and R ²⁰ independently of one another are linear or branched, saturated or unsaturated, substituted (for example substituted by a phenyl radical) or unsubstituted alkyl radicals having 1 to 18 carbon atoms.

gekennzeichnet ist.Advantageous benzotriazole in the context of the present invention is also the 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole trisiloxane, which is sold by Messrs. Chimex under the trademark Mexoryl ^® XL and by the following chemical structural formula

is marked.

Further advantageous benzotriazoles in the context of the present invention [2,4'-dihydroxy-3- (2N-benzotriazol-2-yl) -5- (1,1,3,3-tetramethylbutyl) -2'-n-octoxy-5'-benzoyl] diphenylmethane, 2, 2 'methylene-bis- [6- (2H-benzotriazol-2-yl) -4- (methyl) phenol], 2,2'-methylene-bis- [6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol], 2- (2'-hydroxy-5'-octylphenyl) benzotriazole, benzotriazole 2- (2'-hydroxy-3 ', 5'-di-t-amylphenyl) and 2- (2'-hydroxy-5'-methylphenyl) benzotriazole.

One further in the context of the present invention, advantageous UV filter is the diphenylbutadiene compound described in EP-A-0 916 335 the following formula.

One further in the context of the present invention, advantageous UV-A filter is the 2- (4-ethoxy-anilinomethylene) -propanedicarboxylic acid diethyl ester described in EP-A-0 895 776 the following formula.

welche von der BASF Aktiengesellschaft als UV-A Filter unter der Warenbezeichnung UVINUL^® A Plus vertrieben wird.Also advantageous for the purposes of the present invention is an amino-substituted hydroxybenzophenone of the following formula:

which is sold by BASF Aktiengesellschaft as UV-A filter under the trade name Uvinul ^® A Plus.

A specific aspect of the invention relates to the use of at least one isoalkanol alkoxilate A) in combination with at least one UV filter and / or at least one pigment for the protection of organic substances Shem material from the damaging effect of light. Suitable pigments are, for. As inorganic pigments, such as titanium dioxide, which can be used as rutile, anatase or brookite. Also suitable are ultramarine blue, iron oxides, silicon oxides, aluminum oxides, Si-Al oxides, and organic pigments, such as phthalocyanines, perylenes, azo compounds, isoindolines, etc. Suitable UV filters are those mentioned above. Surprisingly, the use of isoalkanol alkoxilates A) generally leads to an improvement in the sun protection factor (SPF value, sun protection factors) compared with corresponding compositions which do not contain isoalkanol alkoxylates A).

One Another aspect of the present invention relates to the use said isoalkanol alkoxylates A) as solubilizers in molecularly dispersed Systems. Solid dispersions, ie homogeneous finely divided phases of two or more solids as well as their special case of so-called "solid Solutions "(molecular disperse Systems), as well as their use in pharmaceutical technology are generally known (see Chiou and Riegelmann, J. Pharm. Sci., 1971, 60, 1281-1300. In addition, the present invention also relates to solid solutions at least one invention to be used Copolymer included.

The Production of solid solutions can be by melt process or by the solution process respectively.

When polymeric adjuvant, d. H. Solubilizer for the preparation of such solid dispersions or solid solutions the copolymers of the invention are suitable.

To the melt process can for example, a poorly soluble Active ingredient B) and the selected Copolymer A) in the desired Relationship, z. B. be weighed and mixed in equal parts. To the mixture For example, a free-fall mixer is suitable. The mixture can subsequently, z. In a twin-screw extruder. The diameter of the thus obtained, cooled Product strand consisting of a solid solution of the chosen active substance in the chosen one to be used according to the invention Copolymers, is dependent the diameter of the perforation of the perforated discs of the extruder. By cutting off the cooled product strands With the help of a rotating knife can cylindrical particles to be won, their height dependent is the distance between the perforated disc and the knife. The mean diameter the cylindrical particle is usually about 1000 to about 3000 microns, the height usually about 2000 to about 5000 microns. Larger extrudates can be crushed in a subsequent step.

alternative you can fix it also in the solution process produce. To solve this you usually the selected slightly soluble Active ingredient B) and the selected, serving as a solubilizer according to the invention to be used copolymer A) in a suitable solvent. Subsequently the solution is usually used in cast a suitable mold, and the solvent, for example by drying, removed. The drying conditions are chosen advantageous depending on the properties of active ingredient (eg thermolability) and solvent (eg boiling point).

Under Attention to the material behavior, the resulting molding or the extrudate, for example, with a suitable mill (z. B. pin mill) be crushed. The solid solution It is advantageous to comminute up to an average particle size of less than about 2000 μm, preferably less than about 1000 microns and more preferably less than about 500 microns.

With suitable auxiliaries can now be the resulting bulk material a Tablettiermischung or be processed into a capsule filling. The Tabletting leads one advantageous way by having tablets with hardness of bigger about 35 N, preferably greater than about 60 N, more preferably from about 80 to about 100 N.

The so available Formulations can like traditional ones If necessary, formulations with suitable coating materials for obtaining gastroresistant resistance, retardation, taste masking etc. coated become.

In addition to the application in cosmetics and pharmaceutics, the copolymers A) to be used according to the invention are also suitable as solubilizers in the food sector for nutrients, auxiliaries or additives which are sparingly soluble in water or insoluble in water. B. fat-soluble vitamins or carotenoids. Examples include clear, colored with carotenoids drinks. The invention therefore also relates to food-grade preparations which comprise at least one of the copolymers to be used according to the invention as solubilizer. Food preparations are also within the scope of the present invention Dietary supplements such. As food-containing preparations and dietary foods to understand. In addition, the said copolymers are also suitable as solubilizers for feed additives for animal nutrition.

Also suitable the inventively used Copolymers A) for the preparation of aqueous preparations of nutritional supplements like water-insoluble Vitamins and provitamins such as vitamin A, vitamin A acetate, vitamin D, vitamin E, tocopherol derivatives such as tocopherol acetate and vitamin K.

Examples of effect substances which can be formulated as aqueous active substance composition according to the invention are:
Dyes: z. For example, the dyes described in DE-A 10245209 and the color Index referred to as disperse dyes and as solvent dyes connec tions, which are also referred to as disperse dyes. A compilation of suitable disperse dyes can be found, for example, in Ullmanns Enzyklopadie der technischen Chemie, 4th Edition, Vol. 10, pp. 155-165 (see also Vol. 7, pp. 585ff - anthraquinone dyes; Vol. 8, pp. 244ff - azo dyes; Vol. 9, p. 313ff - quinophthalone dyes). This reference and the compounds mentioned therein are hereby incorporated by reference. Disperse dyes and solvent dyes suitable for the present invention include various classes of dyes having different chromophores, for example, anthraquinone dyes, monoazo and disazo dyes, quinophthalones, methine and azamethine dyes, naphthalimide dyes, naphthoquinone dyes, and nitro dyes. Examples of disperse dyes which are suitable according to the invention are the disperse dyes of the following Color Index list: CI Disperse Yellow 1-228, CI Disperse Orange 1-148, CI Disperse Red 1-349, CI Disperse Violet 1-97, CI Disperse Blue 1-349, CI Disperse Green 1-9, CI Disperse Brown 1-21, CI Disperse Black 1-36. Examples of solvent dyes suitable according to the invention are the compounds of the following Color Index list: CI Solvent Yellow 2-191, CI Solvent Orange 1-113, CI Solvent Red 1-248, CI Solvent Violet 2-61, CI Solvent Blue 2- 143, CI Solvent Green 1-35, CI Solvent Brown 1-63, CI Solvent Black 3-50. Further suitable dyes according to the invention are derivatives of naphthalene, of anthracene, of perylene, of terylene, of quarterylene, and also of diketopyrrolopyrrole dyes, perinone dyes, coumarin dyes, isoindoline and isoindolinone dyes, porphyrin dyes, phthalocyanine and naphthalocyanine dyes.

Next the aforementioned components can the active ingredients according to the invention and effect compositions also conventional surface-active Contain substances and other additives. If in addition to Isoalkanolalkoxilaten A) further surfactants are used, it is preferably a surfactant mixture according to the invention, as previously defined. On the appropriate and preferred mentioned there Conventional surfactants are fully incorporated herein by reference. To the surface-active substances counting Surfactants, dispersing aids and wetting agents. To the others Counting additives especially thickeners, defoamers, preservatives, Antifreeze stabilizer, etc.

• – Paraffinöle, aromatische Kohlenwasserstoffe und aromatische Kohlenwasserstoffgemische, z. B. Xylole, Solvesso 100, 150 oder 200, und dergleichen,
• – Phenole und Alkylphenole, z. B. Phenol, Hydrochinon, Nonylphenol, etc.
• – Ketone mit mehr als 4 C-Atomen wie Cyclohexanon, Isophoron, Isopheron, Acetophenon, Acetonaphthon,
• – Alkohole mit mehr als 4 C-Atomen wie acetylierter Lanolinalkohol, Cetylalkohol, 1-Decanol, 1-Heptanol, 1-Hexanol, Isooctadecanol, Isopropylalkohol, Oleylalkohol, Benzylalkohol,
• – Carbonsäureester, z. B. Adipinsäuredialkylester wie Adipinsäurebis(2-ethylhexyl)ester, Phthalsäuredialkylester wie Phthalsäurebis(2-ethylhexyl)ester, Essigsäurealkylester (auch verzweigte Alkylgruppen) wie Ethylacetat und Acetoessigsäureethylester, Stearate wie Butylstearat, Glycerinmonostearat, Citrate wie Acetyltributylcitrat, weiterhin Cetyloctanoat, Methyloleat, Methyl-p-hydroxyvbenzoat, Methyltetradecanoat, Propyl-p-hydroxybenzoat, Methylbenzoat, Milchsäureester wir Isopropyllacttat, Butyllactat und 2-Ethylhexyllactat,
• – Pflanzenöle wie Palmöl, Rapsöl, Rizinusöl und Derivate davon wie z. B. oxydiert, Kokusnussöl, Lebertran, Maiskeimöl, Sojabohnenöl, Leinsamenöl, Olivenöl, Erdnussöl, Färberdistelöl, Sesamsamenöl, Grapefruitöl, Basilikumöl, Aprikosenöl, Ingweröl, Geranienöl, Orangenöl, Rosmarienöl, Macadamiaöl, Zwiebelöl, Mandarinenöl, Kiefernöl, Sonnenblumenöl,
• – hydrogenierte Pflanzenöle wie hydrogeniertes Palmöl, hydrogeniertes Rapsöl, hydrogeniertes Sojabohnenöl,
• – tierische Öle wie Schweinefettöl, Fischöle,
• – Dialkylamide mittel bis langkettiger Fettsäuren z. B. Hallcomide sowie
• – Pflanzenölester wie Rapsölmethylester.

Although an advantage of the compositions of the present invention is their low volatile organic content, for some applications it may be desirable to include the compositions of the present invention with organic solvents, oils and fats, preferably such solvents or oils and fats that are environmentally or biocompatible, e.g. , As the aforementioned water-miscible solvent or solvent, oils or fats that are not or only to a limited extent miscible with water, eg. B .:

• - Paraffin oils, aromatic hydrocarbons and aromatic hydrocarbon mixtures, eg. Xylenes, Solvesso 100, 150 or 200, and the like,
• Phenols and alkylphenols, e.g. Phenol, hydroquinone, nonylphenol, etc.
• Ketones with more than 4 C atoms, such as cyclohexanone, isophorone, isopherone, acetophenone, acetonaphthone,
• Alcohols having more than 4 C atoms, such as acetylated lanolin alcohol, cetyl alcohol, 1-decanol, 1-heptanol, 1-hexanol, isooctadecanol, isopropyl alcohol, oleyl alcohol, benzyl alcohol,
• - Carboxylic acid esters, eg. Example, adipic acid such as adipic acid bis (2-ethylhexyl) esters, dialkyl phthalates such as phthalic acid (2-ethylhexyl) esters, alkyl acetates (also branched alkyl groups) such as ethyl acetate and ethyl acetoacetate, stearates such as butyl stearate, glycerol monostearate, citrates such as acetyltributyl citrate, further cetyloctanoate, methyl oleate, methyl p-hydroxybenzoate, methyl tetradecanoate, propyl p-hydroxybenzoate, methyl benzoate, lactic acid ester, isopropyl lactate, butyl lactate, and 2-ethylhexyl lactate,
• - Vegetable oils such as palm oil, rapeseed oil, castor oil and derivatives thereof such. As oxidized, coconut oil, cod liver oil, corn oil, soybean oil, linseed oil, olive oil, peanut oil, safflower oil, sesame seed oil, grapefruit oil, basil oil, apricot oil, ginger oil, geranium oil, orange oil, rosemary oil, macadamia oil, onion oil, Manda pine oil, pine oil, sunflower oil,
• Hydrogenated vegetable oils such as hydrogenated palm oil, hydrogenated rapeseed oil, hydrogenated soybean oil,
• - animal oils such as lard oil, fish oils,
• - Dialkylamides medium to long-chain fatty acids z. B. Hallcomide as well
• - Vegetable oil esters such as rapeseed oil methyl ester.

Suitable thickeners are compounds which give the formulation a pseudoplastic flow behavior, ie high viscosity at rest and low viscosity in the agitated state. Here, for example, polysaccharides or organic layer minerals such as Xanthan Gum ^® (Kelzan ^® from. Kelco), Rhodopol ^® 23 (Rhone Poulenc) or Veegum ^® (from RT Vanderbilt) or Attaclay ^® (Engelhardt) to call, said xanthan gum ^{® is} preferably used.

As for the inventive compositions suitable antifoam agent, for example, silicone emulsions (such. As silicone ^® SRE, from Wacker, or Rhodorsil ^® from Rhodia), long-chain alcohols, fatty acids, organofluorine compounds and mixtures thereof.

Bactericides may be added to stabilize the compositions of the invention against attack by microorganisms. Suitable bactericides are, for example Proxel ^® from. ICI or Acetide ^® RS from. Thor Chemie and Kathon ^® MK from Rohm & Haas.

suitable Antifreezes are organic polyols, eg. For example, ethylene glycol, Propylene glycol or glycerin. These are usually available in quantities of not more than 10% by weight, used based on the total weight of the active ingredient composition to the desired Content of volatile Not to exceed connections. In one embodiment of the invention the proportion thereof of various volatile organic compounds preferably not more than 1% by weight, in particular not more than 1000 ppm.

Possibly can the active ingredient compositions of the invention 1 to 5 wt .-% buffer based on the total amount of produced Formulation for pH regulation contained, whereby the quantity and type of buffer used according to the chemical properties directed the drug or the active ingredients. Examples of buffers are alkali metal salts of weak inorganic or organic acids such. B. phosphoric acid, boric acid, Acetic acid, propionic acid, citric acid, fumaric acid, Tartaric acid, oxalic acid and succinic acid.

The following examples illustrate the invention without, however, limiting it in any way. Example 1: Conditioner Shampoo with Polyquaternium-10 35.70 g Sodium Laureth Sulfate 6.50 g Cocamidopropyl betaines 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.40 g Polyquaternium-10 0.10 g preservative 0.10 g Perfume oil / essential oil ad 100 g Aqua the. Example 2: Conditioner Shampoo with Guar Hydroxypropyltrimonium Chloride 35.70 g Sodium Laureth Sulfate 6.50 g Cocamidopropyl betaines 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.20 g Guar hydroxypropyltrimonium chlorides 0.10 g preservative 0.10 g Perfume oil / essential oil ad 100 g Aqua the. Example 3: Conditioner Shampoo with Polyquaternium-44 35.70 g Sodium Laureth Sulfate 6.50 g Cocamidopropyl betaines 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.50 g Polyquaternium-44 0.10 g preservative 0.10 g Perfume oil / essential oil ad 100 g Aqua the. Example 4: Shampoo Phase A 15.00 g Cocamidopropyl betaines 10.00 g Disodium Cocoamphodiacetate 5.00 g Polysorbate 20 5.00 g Decyl glucosides 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil qs preservative 2,00 g Laureth-3 ad 100 g Aqua the. qs Citric Acid Phase B 3.00 g PEG-150 distearate

manufacturing

Weigh and solve components of phase A; Adjust pH to 6-7. Add phase B and warm to 50 ° C. Allow to cool to room temperature with stirring. Example 5: Shampoo 30.00 g Sodium Laureth Sulfate 6.00 g Sodium cocoamphoacetate 6.00 g C ₁₀ isoalkanol alkoxilate according to the invention 3.00 g Sodium Laureth Sulfate, Glycol Distearate, Cocamide MEA, Laureth-10 2,00 g Dimethicone qs Perfume qs preservative qs Citric Acid 1.00 g Sodium Chloride ad 100 g Aqua the. Example 6: shower gel 20.00 g Ammonium Laureth Sulfate 15.00 g Ammonium Lauryl Sulfate 5.00 g according to the invention C ₁₀ -Isoalkanolalkoxilat 2.50 g Sodium Laureth Sulfate, Glycol Distearate, Cocamide MEA, Laureth-10 0.10 g Perfume oil / essential oil qs preservative 0.50 g Sodium Chloride ad 100 g Aqua the. Example 7: shower gel 40.00 g Sodium Laureth Sulfate 5.00 g Decyl glucosides 5.00 g C ₁₀ isoalkanol alkoxilate according to the invention 1.00 g panthenol 0.10 g Perfume oil / essential oil qs preservative qs Citric Acid 2,00 g Sodium Chloride ad 100 g Aqua the. Example 8: Shampoo 12.00 g Sodium Laureth Sulfate 1.50 g Decyl glucosides 2.50 g C ₁₀ isoalkanol alkoxilate according to the invention 5.00 g Coco-Glucoside Glyceryl Oleate 2,00 g Sodium Laureth Sulfate, Glycol Distearate, Cocomide MEA, Laureth-10 qs preservative qs Sunset Yelow C.1. 15 985 0.10 g Perfume oil / essential oil 1.00 g Sodium Chloride ad 100 g Aqua the. Example 9: Aerosol hair foam 2,00 g Cocotrimonium methosulfates 0.10 g Perfume oil / essential oil 3.50 g Polyquaternium-46 0.80 g C ₁₀ isoalkanol alkoxilate according to the invention qs Preservative 75.00 g Water that. 10.00 g Propane / butane (3.5 bar) Example 10: Aerosol hair foam 2,00 g Cocotrimonium methosulfates 0.10 g Perfume oil / essential oil 3.50 g PQ-44, 0.80 g C ₁₀ isoalkanol alkoxilate according to the invention qs Preservative 75.00 g Water that. 10.00 g Propane / butane (3.5 bar) Example 11: Aerosol hair foam 2,00 g Cocotrimonium methosulfates 0.10 g Perfume oil / essential oil 3.50 g VP / methacrylamide / vinyl imidazole copolymer 0.80 g C ₁₀ isoalkanol alkoxilate according to the invention qs Preservative 75.00 g Water that. 10.00 g Propane / butane (3.5 bar) Example 12: Hair styling gel Phase A 0.50 g Carbomer or Acrylates / C _10-30 Alkyl Acrylate Crosspolymer 86.40 g Water that. Phase B 0.70 g Triethanolamine Phase C 6.00 g VP / methacrylamide / vinyl imidazole copolymer 5.00 g PVP 0.20 g PEG-25 PABA 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil qs PEG-14 Dimethicone qs preservative 0.10 g Tocopheryl acetate Example 13: Hair styling gel Phase A 0.50 g Carbomer or Acrylates / C _10-30 Alkyl Acrylate Crosspolymer 91.20 g Water that. Phase B 0.90 g Tetrahydroxypropyl Ethylenediamine Phase C 7.00 g VPNA copolymer 0.40 g C ₁₀ isoalkanol alkoxilate according to the invention 0.20 g Perfume oil / essential oil qs preservative 0.10 g Propylene glycol Example 14: Hair Wax Cream 6.00 g Caprylic / Capric Triglycerides 3.00 g Glyceryl stearate 2,00 g Cetyl Alcohol 3.50 g according to the invention C ₁₀ -Isoalkanolalkoxilat 0.50 g Cremophor A6 0.70 g Cremophor A25 0.50 g Dimethicone 0.50 g Vitamin E Acetates 2,00 g Caprylic / Capric Triglyceride and Sodium Acrylate Copolymer 1.00 g D-panthenol USP 0.10 g EDTA 10.00 g setting polymer qs preservative ad 100 g Water that. Example 15: Hair pudding 3.00 g Kollicoat IR (BASF) qs preservative 2,00 g setting polymer 4.00 g Acrylates / beheneth-25 Methacrylate Copolymer 0.70 g C ₁₀ isoalkanol alkoxilate according to the invention 0.50 g Dimethicone Copolyol 0.10 g EDTA 0.20 g Benzophenone-4 ad 100 g Water that. Example 16: Spray Gel Phase A 1.25 g setting polymer 96.15 g Aqua the. Phase B 0.70 g Acrylates / Steareth-20 Itaconate Copolymer 0.10 g Propylene glycol 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g glycerin 0.10 g Perfume oil / essential oil qs preservative Phase C 0.70 g Triethanolamine Example 17: Aerosol hair spray VOC55 5.00 g Acrylates copolymer 0.95 g Aminomethyl propanol 0.50 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil 15.00 g Alcohol 39.00 g Aqua the. 40.00 g Dimethyl ether Example 18: Aerosol hair spray VOC55 2.50 g Octylacrylamide / acrylates / butylaminoethyl methacrylate copolymer 2.50 g VA / crotonates / vinyl neodecanoate copolymer 0.30 g C ₁₀ isoalkanol alkoxilate according to the invention 0.80 g Aminomethyl propanol 0.03 g PPG-3 methyl ether 0.10 g panthenol 0.10 g Benzophenone-3 0.10 g Niacinamide 0.10 g Perfume oil / essential oil 15.00 g Alcohol 38.50 g Aqua the. 40.00 g Dimethyl ether Example 19: Aerosol hair spray VOC55 3.00 g Acrylates copolymer 1.50 g Acrylate / octylacrylamide copolymer 0.52 g Aminomethyl propanol 0.70 g C ₁₀ isoalkanol alkoxilate according to the invention 0.30 g phenyltrimethicones 0.10 g Perfume oil / essential oil 15.00 g Alcohol 39.00 g Aqua the. 40.00 g Dimethyl ether Example 20: Aerosol hair spray VOC80 5.00 g Acrylates copolymer 1.56 g Aminomethyl propanol 0.70 g C ₁₀ isoalkanol alkoxilate according to the invention 0.50 g panthenol 0.10 g phytantriol 12.14 g Aqua the. 55.00 g Alcohol 0.10 g Perfume oil / essential oil 10.00 g Butane 15.00 g Dimethyl ether Example 21: Aerosol hair spray VOC80 3.00 g PEG / PPG-25/25 dimethicone / acrylate copolymer 5.00 g Polyurethane-1 0.10 g C ₁₀ isoalkanol alkoxilate according to the invention 0.36 g Aminomethyl propanol 16.04 g Aqua the. 35.50 g Alcohol 40.00 g Dimethyl ether Example 22: Aerosol hair spray VOC95 0.95 g Aminomethyl propanol 0.60 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Dimethicone Copolyol 0.10 g Cetearyl octanoate 0.10 g panthenol 0.10 g Perfume oil / essential oil 54.15 g Alcohol 4.00 g Acrylates copolymer 40.00 g Propane / Butane Example 23: Pump Hair Spray 11.20 g PEG / PPG-25/25 dimethicone / acrylate copolymer 2.80 g VP / VA copolymer 1.34 g Aminomethyl propanol 0.30 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil 11.26 g Aqua the. 73.00 g Alcohol Example 24: Pump hair spray VOC55 2,00 g VP / methacrylamide / vinyl imidazole copolymer 1.90 g Polyquaternium-46 2,00 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil 55.00 g Alcohol 39.00 g Aqua the. Example 25: Liquid Makeup Phase A 1.70 g Glyceryl stearate 1.70 g cetyl alcohol 1.70 g Ceteareth-6 1.70 g Ceteareth-25 5.20 g Caprylic / capric triglyceride 5.20 g mineral oil Phase B qs preservative 4.30 g Propylene glycol 2.50 g C ₁₀ isoalkanol alkoxilate according to the invention 59.50 g Aqua the. Phase C 0.10 g Perfume oil / essential oil Phase D 2,00 g iron oxides 12.00 g Titanium dioxide

production:

Heat Phase A and Phase B separately to 80 ° C. Then mix phase B in phase A with a stirrer. Allow to cool to 40 ° C and add Phase C and Phase D. Homogenize repeatedly. Example 26: Eyeliner Phase A 40.60 g least. water 0.20 g Disodium EDTA qs preservative Phase B 0.60 g xanthan gum 0.40 g Veegum 3.00 g butylene 0.20 g Polysorbate-20 Phase C 15.00 g Iron oxide / Al powder / silicon dioxide (eg Sicopearl ^® Fantastico Gold from BASF) Phase D 10.00 g least. water 30.00 g C ₁₀ isoalkanol alkoxilate according to the invention

production:

Premix Phase B. Mix phase B into phase A with a propeller mixer, allowing the thickener to swell. Wet Phase C with Phase D, add everything in Phase AB and mix well. Example 27: Sunscreen Gel Phase A 0.90 g C ₁₀ isoalkanol alkoxilate according to the invention 8.00 g Octyl Methoxycinnamate (Uvinul MC 80 ^™ from BASF) 5.00 g Octocrylene (Uvinul N 539 ^™ from BASF) 0.80 g Octyl triazone (Uvinul T 150 ^™ from BASF) 2,00 g Butyl methoxydibenzoylmethane (Uvinul BMBM ^™ from BASF) 2,00 g Tocopheryl acetate 0.10 g Perfume oil / essential oil Phase B 0.30 g Acrylate / C _10-30 alkyl acrylate copolymer 0.20 g Carbomer 5.00 g glycerin 0.20 g Disodium EDTA qs preservative 75.30 g least. water Phase C 0.20 g sodium hydroxide

production:

Mix the components of phase A. Swell phase B and stir in phase A with homogenization. Neutralize with Phase C and homogenize again. Example 28: Sunscreen emulsion with TiO ₂ and ZnO ₂ Phase A 1.00 g hydrogenated castor oil PEG-7 5.00 g C ₁₀ isoalkanol alkoxilate according to the invention 2,00 g PEG-45 / dodecyl glycol copolymer 3.00 g isopropyl 7.90 g Jojoba (Buxus chinensis) Oil 4.00 g Octyl Methoxycinnamate (Uvinul MC 80) 2,00 g 4-methylbenzylidene camphor (Uvinul MBC 95) 3.00 g Titanium Dioxide, Dimethicone 1.00 g Dimethicone 5.00 g Zinc oxide, dimethicone Phase B 0.20 g Disodium EDTA 5.00 g glycerin qs preservative 60.80 g least. water Phase C 0.10 g Perfume oil / essential oil

production:

Heat phases A and B separately to approx. 85 ° C. Stir phase B into phase A and homogenize. Cool to about 40 ° C, add phase C and briefly homogenize again. Example 29: Facial Toner for Dry and Sensitive Skin Phase A 3.00 g C ₁₀ isoalkanol alkoxilate according to the invention 0.10 g Perfume oil / essential oil 0.30 g bisabolol Phase B 3.00 g glycerin 1.00 g Hydroxyethyl cetyldimonium phosphates 5.00 g Witch hazel (Hamamelis virginiana) distillate 0.50 g panthenol qs preservative 87.60 g least. water

production:

Clear phase A clearly. Stir phase B into phase A. Example 30: Face wash paste with peeling effect Phase A 73.00 g least. water 1.50 g Carbomer qs preservative Phase B qs perfume oil 7.00 g Potassium Cocoyl Hydrolyzed Protein 4.00 g C ₁₀ isoalkanol alkoxilate according to the invention Phase C 1.50 g triethanolamine Phase D 13.00 g Polyethylene (Luwax A ^™ from BASF)

production:

Let phase A swell. Clear phase B clearly. Stir phase B into phase A. Neutralize with Phase C. Then stir in phase D. Example 31: Soap Phase A 25.00 g potassium cocoate 20.00 g Disodium Cocoamphodiacetate 2,00 g Lauramide DEA 1.00 g Glycol Stearate 2,00 g C ₁₀ isoalkanol alkoxilate according to the invention 50.00 g least. water qs citric acid Phase B qs preservative 0.10 g Perfume oil / essential oil

production:

Heat phase A to 70 ° C. while stirring until everything is homogeneous, adjust the pH to 7.0-7.5 with citric acid, allow to cool to 50 ° C. and add phase B. Example 32: facial cleansing milk type O / W Phase A 1.50 g Ceteareth-6 1.50 g Ceteareth-25 2,00 g Glyceryl stearate 2,00 g cetyl alcohol 10.00 g mineral oil Phase B 5.00 g propylene glycol qs preservative 1.00 g C ₁₀ isoalkanol alkoxilate according to the invention 66.30 g least. water Phase C 0.20 g Carbomer 10.00 g Cetearyl octanoate Phase D 0.40 g Tetrahydroxypropyl Ethylenediamine Phase E 0.10 g Perfume oil / essential oil 0.10 g bisabolol

production:

Heat phases A and B separately to approx. 80 ° C. Stir phase B into phase A while homogenizing, after-homogenize shortly. Stir phase C, stir in phase AB, neutralize with phase D and posthumogenize. Cool to about 40 ° C, add phase E, homogenize again. Example 33: Transparent soap 4.20 g sodium hydroxide 3.60 g least. water 10.00 g C ₁₀ isoalkanol alkoxilate according to the invention 22.60 g propylene glycol 18.70 g glycerin 5.20 g Cocoamide DEA 2.40 g Cocamine oxides 4.20 g sodium lauryl sulfate 7.30 g myristic 16.60 g stearic acid 5.20 g tocopherol

production:

Mix all ingredients. Melt the mixture clearly at 85 ° C. Immediately pour into the mold. Example 34: Shaving foam 6.00 g Ceteareth-25 5.00 g Poloxamer 407 52.00 g least. water 1.00 g triethanolamine 5.00 g propylene glycol 1.00 g Lanolin-PEG-75 5.00 g C ₁₀ isoalkanol alkoxilate according to the invention qs preservative 0.10 g Perfume oil / essential oil 25.00 g Sodium Laureth Sulfate

production:

Weigh everything together, then stir until dissolved. Filling: 90 parts of active substance and 10 parts of propane / butane mixture 25:75. Example 35: After Shave Balm Phase A 0.25 g Acrylate / C _10-30 alkyl acrylate copolymer 1.50 g tocopheryl acetate 0.20 g bisabolol 10.00 g Caprylic / capric triglyceride qs perfume oil 1.00 g hydrogenated castor oil PEG-40 Phase B 1.00 g panthenol 15.00 g alcohol 5.00 g glycerin 0.05 g hydroxyethyl 1.90 g C ₁₀ isoalkanol alkoxilate according to the invention 64.02 g least. water Phase C 0.08 g sodium hydroxide

production:

Mix the components of phase A. Stir phase B into phase A while homogenizing; shortly afterwards homogenize. Neutralize with Phase C and homogenize again. Example 36: Nourishing cream Phase A 2,00 g Ceteareth-6 2,00 g Ceteareth-25 2,00 g cetearyl 3.00 g Glyceryl Stearate SE 5.00 g mineral oil 4.00 g Jojoba (Buxus chinensis) oil 3.00 g cetearyl 1.00 g Dimethicone 3.00 g Mineral oil, lanolin alcohol Phase B 5.00 g propylene glycol 0.50 g Veegum 1.00 g panthenol 1.70 g C ₁₀ isoalkanol alkoxilate according to the invention 6.00 g Polyquaternium-44 qs preservative 60.80 g least. water Phase C qs Perfume

production:

Heat phases A and B separately to approx. 80 ° C. Homogenize phase B. Stir phase B into phase A while homogenizing, after-homogenize shortly. Cool to about 40 ° C, add phase C and briefly homogenize again. Example 37: Toothpaste Phase A 34.79 g least. water 3.00 g C ₁₀ isoalkanol alkoxilate according to the invention 20.00 g glycerin 0.76 g sodium monofluorophosphate Phase B 1.20 g sodium Phase C 0.80 g aromatic oil 0.06 g saccharin 0.10 g preservative 0.05 g bisabolol 1.00 g panthenol 0.50 g Tocopheryl acetate 2.80 g silica 1.00 g sodium lauryl sulfate 7.90 g Dicalcium phosphate anhydrous 25.29 g Dicalcium phosphate dihydrate 0.45 g Titanium dioxide

production:

Solve phase A. Place phase B in phase A and dissolve. Add phase C and allow to stir under vacuum at room temperature for approx. 45 min. Example 38: Mouthwash Phase A 2,00 g aromatic oil 4.50 g C ₁₀ isoalkanol alkoxilate according to the invention 1.00 g bisabolol 30.00 g alcohol Phase B 0.20 g saccharin 5.00 g glycerin qs preservative 5.00 g Poloxamer 407 52.30 g least. water

production:

Separate phase A and phase B separately. Stir phase B into phase A. Example 39: Denture adhesive Phase A 0.20 g bisabolol 1.00 g Beta carotene qs aromatic oil 20.00 g Cetearyl octanoate 5.00 g silica 33.80 g mineral oil Phase B 5.00 g C ₁₀ isoalkanol alkoxilate according to the invention 35.00 g PVP (20% solution in water)

production:

Mix phase A well. Stir phase B into phase A. Example 40: Aromatherapy bath

production:

Mix the components of phase A. Add the components of phase B one after the other and mix well. Adjust the desired pH with citric acid. Example 41: Shampoo with babassu oil, and Luviquat Mono ^® LS

production:

Mix the components of phase A. Add the components of phase B one after the other and dissolve. Example 42: Shower bath with vitamins

production:

Mix phase A. Add the components of phase B one after the other and dissolve clearly. Example 43: Aftershave

production:

Mix phases A and B separately. Stir phase B / C / D into phase A while homogenizing. Example 44: Bubble bath

production:

Mix phase A and neutralize with phase B. Add phase B and stir until a clear solution is obtained. Example 45: transparent deodorant stick

production:

Weigh in the components of phase A and melt. Pour the molten mass into suitable molds and allow to solidify. Example 46: Gel with essential oils

production:

Let phase A swell. Clear phase B clearly. Example 47: Relaxing Sport Gel

production:

Mix phase A. Stir phase B into phase A until homogeneous. Stir in phase C slowly. Example 48: Oil bath

production:

Everything weigh together, stir until solved.

Claims (18)

Surfactant mixture containing A) at least one isoalkanol alkoxilate obtainable by alkoxylating at least one C ₁₀ isoalkanol with at least one C ₂ to C ₆ alkylene oxide, and B) at least one surfactant other than A). A surfactant mixture according to claim 1, wherein the isoalkanol alkoxilates A) are selected from compounds of the formula I. RO- (Alk ¹ O) _x - (Alk ² O) _y - (Alk ³ O) _z -H (I) wherein R is branched C ₁₀ alkyl, Alk ¹ , Alk ² and Alk ³ independently of one another represent straight-chain or branched C ₂ -C ₅ alkylene, wherein Alk ¹ and Alk ² and Alk ² and Alk ³ , if present, itself with respect to their carbon atom number or structure, x + y + z is a number from 1 to 100. Surfactant mixture according to one of claims 1 or 2, wherein component B) comprises at least one anionic surfactant, that selected is among carboxylates, alkyl ether carboxylates, alkyl sulfates, alkyl ether sulfates, Alkyl sulfonates, aryl sulfonates, alkylaryl sulfonates, alkyl succinates, Alkyl sulfosuccinates, N-acyl sarcosinates, N-acyl taurates, acyl isothionates, N-acylglutamates, alkyl phosphates, alkyl ether phosphates, methylcelluloses, Condensation products of sulfonated naphthalene and derivatives thereof with formaldehyde, condensation products of naphthalenesulfonic acids, phenolic and / or phenolsulfonic acids with Formaldehyde or with formaldehyde and urea, protein hydrolysates, Lignin sulphite waste liquors and mixtures thereof. A surfactant mixture according to claim 3, wherein component B) is selected from C ₈ -C ₃₀ -alkyl sulfates, C ₈ -C ₃₀ -alkyl ether sulfates, C ₈ -C ₃₀ -alkyl sulfonates and mixtures thereof. A surfactant mixture according to any one of the preceding claims which the component A) in an amount of 0.01 to 50 wt .-%, preferably 0.05 to 20 wt .-%, in particular 0.1 to 10 wt .-%, based on the total weight of the surfactant mixture. Cosmetic or pharmaceutical agent containing a) at least one isoalkanol alkoxylate A) as in one of claims 1 or 2 defines b) at least one cosmetically or pharmaceutically acceptable active or effect substance, and c) optionally at least another cosmetically or pharmaceutically acceptable excipient. Means according to claim 6, wherein at least one of Components b) or c) a compound having a solubility in water of below 10 g / l at 25 ° C and 1013 mbar. Agent according to one of claims 6 or 7 in the form of a Gels, foam, sprays, an ointment, cream, emulsion, suspension, Lotion, milk or paste. Agent according to one of claims 6 to 8 in the form of a hair treatment agent, preferably in the form of a hair fixative, hair mousse, hair gel, Shampoos, hair sprays, hair mousse, top fluids, leveling agents for perms, hair coloring and bleach, "hot oil treatment" preparations, a hair lotion, hair conditioner or hair emulsion. Agent according to one of claims 6 to 8 in the form of a skin-cosmetic Preparation, preferably in the form of a skin cleanser, skin care product, Skin protection product or means of decorative cosmetics. Agent according to one of claims 6 to 8 in the form of a tooth or oral hygiene preparation. Active or effect composition containing - at least an isoalkanol alkoxilate A) as in any one of claims 1 or 2 defines, and - at least an effect or effect substance that in water at 25 ° C and 1013 mbar a solubility below 10 g / l. A composition according to claim 12, wherein the active or effect substance is selected under UV absorber nutrients, food additives and additives, nutritional supplements, preferably vitamins and provitamins, animal feed and coloring matter. aqueous A composition according to any one of claims 12 or 13, comprising aqueous Medium as a continuous phase and at least one in the continuous Phase solubilized or dispersed drug and / or effect substance. Use of at least one isoalkanol alkoxylate A) as in any of the claims 1 or 2, as a solubilizer for producing aqueous Formulations of active ingredients and effect substances in water at 25 ° C / 1013 mbar a solubility below 10 g / l. Use of at least one isoalkanol alkoxylate A) as in any of the claims 1 or 2 as a solubilizer in molecularly dispersed systems. Use of at least one at least one isoalkanol alkoxylate, as in any of the claims 1 or 2, as a solubilizer in combination with at least a silicone compound. Use of at least one at least one isoalkanol alkoxylate A) as in any of the claims 1 or 2, as a component of at least one UV absorber and / or at least one sunscreen pigment-containing composition for improving the sun protection factor of this composition.