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DE102005009217A1 - Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen - Google Patents

Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen Download PDF

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Publication number
DE102005009217A1
DE102005009217A1 DE102005009217A DE102005009217A DE102005009217A1 DE 102005009217 A1 DE102005009217 A1 DE 102005009217A1 DE 102005009217 A DE102005009217 A DE 102005009217A DE 102005009217 A DE102005009217 A DE 102005009217A DE 102005009217 A1 DE102005009217 A1 DE 102005009217A1
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Germany
Prior art keywords
pain
drug
polymorph
measured
phosphoric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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DE102005009217A
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German (de)
English (en)
Inventor
Michael Dr. Gruss
Andreas Dr. Fischer
Wolfgang Dr. Hell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
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Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102005009217A priority Critical patent/DE102005009217A1/de
Priority to TW095104476A priority patent/TW200640840A/zh
Priority to AU2006218133A priority patent/AU2006218133B8/en
Priority to EP06707124A priority patent/EP1851192A1/en
Priority to EP06707123A priority patent/EP1851191A1/de
Priority to JP2007556542A priority patent/JP2008531510A/ja
Priority to PCT/EP2006/001548 priority patent/WO2006089708A1/en
Priority to CNA2006800059649A priority patent/CN101137615A/zh
Priority to PCT/EP2006/001547 priority patent/WO2006089707A1/de
Priority to RU2007135271/04A priority patent/RU2007135271A/ru
Priority to CN2006800062321A priority patent/CN101128417B/zh
Priority to AU2006218132A priority patent/AU2006218132B2/en
Priority to US11/885,039 priority patent/US8309610B2/en
Priority to MX2007010361A priority patent/MX2007010361A/es
Priority to NZ556338A priority patent/NZ556338A/en
Priority to RU2007135270/04A priority patent/RU2007135270A/ru
Priority to KR1020077021682A priority patent/KR20070112812A/ko
Priority to CA002598845A priority patent/CA2598845A1/en
Priority to KR1020077021974A priority patent/KR20070107162A/ko
Priority to BRPI0606146-0A priority patent/BRPI0606146A2/pt
Priority to CA002598579A priority patent/CA2598579A1/en
Priority to NZ560204A priority patent/NZ560204A/en
Priority to JP2007556543A priority patent/JP2008531511A/ja
Priority to BRPI0606234-2A priority patent/BRPI0606234A2/pt
Priority to MX2007010192A priority patent/MX2007010192A/es
Priority to ARP060100684A priority patent/AR053145A1/es
Priority to PE2006000228A priority patent/PE20061100A1/es
Priority to US11/361,954 priority patent/US20060211887A1/en
Publication of DE102005009217A1 publication Critical patent/DE102005009217A1/de
Priority to IL185468A priority patent/IL185468A0/en
Priority to IL185467A priority patent/IL185467A0/en
Priority to NO20074676A priority patent/NO20074676L/no
Priority to NO20074673A priority patent/NO20074673L/no
Priority to ZA200708153A priority patent/ZA200708153B/xx
Priority to IL212292A priority patent/IL212292A0/en
Priority to IL212291A priority patent/IL212291A0/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/34—Tobacco-abuse
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    • A61P25/36—Opioid-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE102005009217A 2005-02-25 2005-02-25 Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen Withdrawn DE102005009217A1 (de)

Priority Applications (35)

Application Number Priority Date Filing Date Title
DE102005009217A DE102005009217A1 (de) 2005-02-25 2005-02-25 Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen
TW095104476A TW200640840A (en) 2005-02-25 2006-02-10 Phosphatsalze der 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1, 3-dihydroxy-cyclohexanverbindungen
CA002598845A CA2598845A1 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl)-1,3-dihydr oxy-cyclohexane compounds
KR1020077021974A KR20070107162A (ko) 2005-02-25 2006-02-21 6-디메틸아미노메틸-1-(3-메톡시페닐)-1,3-디하이드록시사이클로헥산 화합물의 인산염
EP06707123A EP1851191A1 (de) 2005-02-25 2006-02-21 Phosphatsalze der 6-dimethylaminomethyl-l- (3-methoxyphenyl) -1,3-dihydroxy- cyclohexanverbindungen
JP2007556542A JP2008531510A (ja) 2005-02-25 2006-02-21 ６−ジメチルアミノメチル−１−（３−メトキシフェニル）−１，３−ジヒドロキシ−シクロヘキサン化合物のリン酸塩
PCT/EP2006/001548 WO2006089708A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
CNA2006800059649A CN101137615A (zh) 2005-02-25 2006-02-21 6-二甲基氨基甲基-1-（3-甲氧基苯基）-1，3-二羟基-环己烷化合物的磷酸盐
PCT/EP2006/001547 WO2006089707A1 (de) 2005-02-25 2006-02-21 Phosphatsalze der 6-dimethylaminomethyl-l- (3-methoxyphenyl) -1,3-dihydroxy- cyclohexanverbindungen
RU2007135271/04A RU2007135271A (ru) 2005-02-25 2006-02-21 Фосфатные соли 6-диметиламинометил-1-(3-метоксифенил)-1, 3-дигидрооксициклогексановых соединений
CN2006800062321A CN101128417B (zh) 2005-02-25 2006-02-21 (1rs,3rs,6rs)-6-二甲氨基甲基-1-(3-甲氧基-苯基)环己烷-1,3-二醇盐酸盐的晶形
AU2006218132A AU2006218132B2 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds
US11/885,039 US8309610B2 (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride
MX2007010361A MX2007010361A (es) 2005-02-25 2006-02-21 Sales de fosfato de los compuestos de 6-dimetilaminometil-1(3-meto xifenil)-1, 3-dihidroxi-ciclohexano.
NZ556338A NZ556338A (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
RU2007135270/04A RU2007135270A (ru) 2005-02-25 2006-02-21 Кристаллические модификации гидрохлорида (1rs,3rs,6rs)-6-диметиламиноиетил-1-(3-метоксифенил)циклогексан-1,3-диола
KR1020077021682A KR20070112812A (ko) 2005-02-25 2006-02-21 (1ｒｓ,3ｒｓ,6ｒｓ)-6-디메틸아미노메틸-1-(3-메톡시-페닐)사이클로헥산-1,3-디올 하이드로클로라이드의 결정질 형태
AU2006218133A AU2006218133B8 (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-Dimethvlaminomethyl-1-(3-methoxy- phenyl)cyclohexane-1 ,3-diol hydrochloride
BRPI0606146-0A BRPI0606146A2 (pt) 2005-02-25 2006-02-21 compostos de sais fosfato 6-dimetilaminometil-1-(3-metoxifenil)-1,3-dihidroxicicl ohexano
EP06707124A EP1851192A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
CA002598579A CA2598579A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
NZ560204A NZ560204A (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy- phenyl)cyclohexane-1,3-diol hydrochloride
JP2007556543A JP2008531511A (ja) 2005-02-25 2006-02-21 （１ｒｓ，３ｒｓ，６ｒｓ）−６−ジメチルアミノメチル−１−（３−メトキシ−フェニル）シクロヘキサン−１，３−ジオール塩酸塩の結晶形
BRPI0606234-2A BRPI0606234A2 (pt) 2005-02-25 2006-02-21 formas cristalinas de cloridrato de (1rs,3rs,6rs)-6-dimetilaminometil-1-(3-metóxi-fenil) ciclo-hexano-1,3-diol
MX2007010192A MX2007010192A (es) 2005-02-25 2006-02-21 Formas cristalinas del clorhidrato de (1rs, 3rs, 6rs)-6-dimetilaminometil-1-(3-metoxi-fenil) ciclohexano-1, 3-diol.
ARP060100684A AR053145A1 (es) 2005-02-25 2006-02-24 Sales de fosfato del compuesto 6-dimetilaminometil-1 (3-metoxifenil)-1,3-hidroxi-ciclohexano
PE2006000228A PE20061100A1 (es) 2005-02-25 2006-02-27 Sales de fosfato de 6-dimetilaminometil-1-(3-metoxifenil)-1,3-dihidroxicliclohexano
US11/361,954 US20060211887A1 (en) 2005-02-25 2006-02-27 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
IL185468A IL185468A0 (en) 2005-02-25 2007-08-23 Phosphate salts of 6-dimethylaminomethyl-l -(3-methoxyphenyl)-1,3-dihydroxy cyclohexane compounds
IL185467A IL185467A0 (en) 2005-02-25 2007-08-23 Crystalline forms of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride
NO20074676A NO20074676L (no) 2005-02-25 2007-09-13 Krystallinske former av (1 RS, 3RS, 6RS)-6-dimetylaminometyl-1-(3-metoksy-fenyl)cykloheksan-1,3-diol hydroklorid
NO20074673A NO20074673L (no) 2005-02-25 2007-09-13 Fosfatsalter av 6-dimetylaminometyl-L-(3-metoksyfenyl)1,3,dihydroksycykloheksanforbindelser
ZA200708153A ZA200708153B (en) 2005-02-25 2007-09-21 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxycyclohexane
IL212292A IL212292A0 (en) 2005-02-25 2011-04-13 Crystalline form of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride, a proess, for its preparation and pharmaceutical compositions comprising it
IL212291A IL212291A0 (en) 2005-02-25 2011-04-13 Crystalline form of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride, pharmaceutical compositions comprising it and a process for its preparation

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138558A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur schmerzbehandlung bei arthrose
WO2011029614A1 (en) * 2009-09-14 2011-03-17 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

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KR20080039400A (ko) 2005-07-07 2008-05-07 파남 컴퍼니스 인크. 고수용성 약물의 서방성 약학 조성물

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EP0753506B1 (de) * 1995-07-11 1999-08-18 Grünenthal GmbH 6-Dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe

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DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
DE10333835A1 (de) * 2003-07-24 2005-03-10 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung

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Publication number Priority date Publication date Assignee Title
EP0753506B1 (de) * 1995-07-11 1999-08-18 Grünenthal GmbH 6-Dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138558A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur schmerzbehandlung bei arthrose
WO2011029614A1 (en) * 2009-09-14 2011-03-17 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

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NO20074673L (no) 2007-10-19
NZ556338A (en) 2009-11-27
WO2006089707A1 (de) 2006-08-31
TW200640840A (en) 2006-12-01
ZA200708153B (en) 2008-10-29
JP2008531510A (ja) 2008-08-14
AU2006218132B2 (en) 2011-10-06
MX2007010361A (es) 2008-02-21
PE20061100A1 (es) 2007-01-04
EP1851191A1 (de) 2007-11-07
CN101137615A (zh) 2008-03-05
AU2006218132A1 (en) 2006-08-31
AR053145A1 (es) 2007-04-25
BRPI0606146A2 (pt) 2009-06-02
RU2007135271A (ru) 2010-02-27
IL185468A0 (en) 2008-01-06
KR20070107162A (ko) 2007-11-06
CA2598845A1 (en) 2006-08-31

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