DE102004024795A1 - Cosmetic composition, useful e.g. as a product for hair dressing, as shampoos, hair washing, coloring- and decoloring hair, comprises sulfonated and/or sulfur containing polyarylether ketone in the conventional cosmetic additives - Google Patents

Abstract

Cosmetic composition (I) comprises sulfonated and/or sulfur containing polyarylether ketone in the conventional cosmetic additives. Independent claims are also included for: (1) a method of treating hair comprising contacting the hair with (I) and optionally rinsing with water; (2) a composition for mouth and dental care comprising sulfonated polyarylether ketone and usual additives for the mouth and dental care; and (3) use of sulfonated and/or sulfur containing polyarylether ketone in pharmaceutical preparations.

Description

The The invention relates to cosmetic compositions containing sulfonated and / or Sulfur-containing polyaryletherketones and customary in cosmetics additives.

polyaryletherketones are used in the prior art for various purposes. For example, in fuel cell technology, polyetheretherketones from the group of polyaryletherketones as or in polymer electrolyte membranes used. These polyetheretherketones are functionalized in this case, that they are used for ion exchange and thereby preferably for uptake and Emission of protons are capable.

When Sulfonating reagents for Polyaryletherketone example, oleum, concentrated sulfuric acid or Sulfur trioxide in a suitable organic solvent described. Also, the lithiation using butyl lithium, implementation with sulfur dioxide and subsequent Oxidation is known.

The DE 100 47 551 A1 discloses the use of sulfonated polyether ether ketones as proton exchange membranes, describing the use of the membranes in direct methanol fuel cells.

The EP 574 791 A2 describes the sulfonation of polyaryl ether ketones by means of sulfonic acid. The sulfonated polymer is used inter alia in fuel cells as an electrolyte membrane.

In the cosmetics, in particular in cosmetic preparations consists a need for polymers that are common in cosmetic preparations solvents such as water, alcohols or mixtures thereof are soluble, show the good properties as a film former and films as low Have stickiness and good mechanical properties.

In cosmetic preparations for the skin can Polymers have a particular effect, e.g. to moisturizing and Conditioning the skin and improving the skin feel.

In cosmetic preparations for the hair will be polymers for strengthening, structural improvement and Shaping the hair used. They increase the combability and improve the Handle of the hair.

disadvantage Numerous polymers which are suitable as film formers is their inadequate solubility in usual in cosmetics Solvents. To lift this problem be, are sometimes consuming measures such as copolymerization of hydrophobic and hydrophilic monomers for adjustment the solubility performed. The resulting films are often tacky and do not exhibit the desired mechanical properties.

task The present invention has been to polymers for use in cosmetic To provide preparations whose solubility in for cosmetic Preparations usual solvents is well adjustable and which are able to use clear movies with as possible low tack and good mechanical properties.

polyaryletherketones

These Task has been solved by the use of sulfonated and / or sulfur-containing polyaryletherketones.

Especially suitable are the sulfonated and / or sulfur-containing polyaryletherketones for the use in cosmetic, especially hair and skin cosmetic preparations.

Another The invention relates to hair and skin cosmetics containing sulfonated and / or sulfur-containing polyaryletherketones.

In addition, the sulfonated and / or sulfur-containing polyaryl ether ketones can be used in agents be used for oral and dental care. Another object of the invention are therefore means for oral and dental care containing sulfonated and / or sulfur-containing polyaryletherketones and other additives customary for preparations of oral and dental care.

in the The following are sulfonated and / or sulfur-containing polyaryletherketones referred to as sulfonated polyaryletherketones. polyaryletherketones are polyaryletherketones, polyaryletheretherketones, polyaryletherketone ketones and polyaryletheretherketone ketones, preferred polyaryletherketones are polyaryletherketones, polyaryletheretherketones, polyaryletherketone ketones.

The agents according to the invention can the sulfonated products in principle all Polyaryletherketone containing by reaction of polyaryletherketones can be produced with suitable sulfonating reagents. Under sulfonated Polyaryletherketones are within the scope of the present invention sulfonated polyaryletheretherketones (sPEEK), sulfonated polyaryletherketones (sPEK), sulfonated polyaryl ether ketone ketones (sPEKK) or sulfonated Polyaryletheretherketonketone (sPEEKK) understood.

Examples of suitable sulfonating reagents for polyaryletherketones include oleum, concentrated sulfuric acid, sulfur trioxide, trimethylsilylsulfonyl chloride or lithiation with butyllithium / sulfur dioxide treatment / potassium permanganate oxidation in a suitable solvent (for example JP 2001233974 A2 or DE-A1 100 47 551).

wobei
Ar einen Phenylenring mit p- und/oder m-Bindungen
Ar' eine Phenylen-, Naphthylen-, Biphenylen, Anthrylen- oder eine andere zweiwertige aromatische Einheit,
X, N und M unabhängig voneinander 0 oder 1,
Y 0, 1, 2 oder 3,
P 1, 2, 3 oder 4
bedeuten (das Polymere mit p = 1, X = 0, M = 1, Y = 0, N = 0, ist unter der Bezeichnung Victrex^® im Handel verfügbar) sowie in EP-A 0 574 791 bevorzugt eingesetzten Polyaryletherketone der Formeln IV, V und VI I(EP-A 0 574 791, S.5), auf die erfindungsgemäß vollumfänglich Bezug genommen wird.In accordance with the invention, the sulfonated products are preferably used in principle for all polyaryl ether ketones which are accessible to sulfonation via alkanesulfonic acids, for example the polyaryl ether ketones of the formula I mentioned in EP-A 0 574 791 (EP-A 0 574 791, p.

in which
Ar is a phenylene ring with p and / or m bonds
Ar 'is a phenylene, naphthylene, biphenylene, anthrylene or other divalent aromatic moiety,
X, N and M are independently 0 or 1,
Y 0, 1, 2 or 3,
P 1, 2, 3 or 4
mean (the polymer, with p = 1, X = 0, M = 1, Y = 0, N = 0, is available under the name Victrex ^® commercially) as well as in EP-A 0,574,791 preferably polyaryl ether ketones of the formulas IV, V and VI I (EP-A 0 574 791, p.5), to which full reference is made according to the invention.

To A further embodiment of the invention is a sulfonated aromatic polyether ketone used starting from a copolymer, that consists of at least 2 different units of the general Formulas IV, V and VI can be represented by sulfonation is available.

As preferred sulfonated polyaryletherketones be in the present invention sulfo nether polyetheretherketones (sPEEK), sulfonated polyether ketones (sPEK) or sulfonated polyether ketone ketones (sPEKK) used.

Very particular preference sulfonated forms of PEEK ^® - and PEK ^® - polymer types (. Manufacturer Victrex plc ^®), in particular sulfonated PEEK ^® 450P, sulfonated PEEK ^® 150P and sulfonated PEK ^® P22 used.

sulfonation

The in the cosmetic agents preferred sulfonated polyaryletherketones are available by a process comprising the reaction of at least one polyaryletherketone with at least one alkanesulfonic acid to give sulfur containing polyaryletherketones. The procedure and the resulting available sulfonated polyaryl ether ketones are described below and are the subject of the German patent application with the file number 10309135.1.

Especially It is preferred to use polymers in the cosmetics. used for their preparation in the process methanesulfonic acid as alkanesulfonic acid and / or the at least one polyaryletherketone to be sulfonated is a polyetheretherketone.

A exact adjustment of the degree of sulfonation means a setting which in general at most around +/- 5 %, preferably at most around +/- 2 % of the desired Sulfonation deviates.

polyaryletherketones with a high degree of sulfonation, e.g. 80% and larger are water soluble and Polyaryl ether ketones with very low degree of sulfonation, e.g. under 40 are poorly soluble in water. For the Use of the sulfonated polyaryl ether ketones in cosmetic Means it is desired water-soluble or in aqueous Solvent mixtures soluble To provide polyaryletherketones. These can be adjusted by a targeted Sulfonierungsgrad be obtained.

Of the Term "degree of sulfonation" refers to Scope of the present invention to the calculated from the means Elemental analysis determined number of sulfur content of the Sulfonic acid groups per Repeating unit of polyaryletherketone. A "degree of sulfonation" of 100% Here, a sulfur-containing polyaryletherketone, in the statistical Agent per repeating unit has a sulfonic acid group (under "sulfonic acid" both the protonated as well as the neutralized form understood).

in the Following are the words "sulfonated polyaryletherketones" both the neutral as well as any salt form of the sulfonated polyaryletherketones Understood.

According to the invention preferably sulfonated polyaryl ether ketones having a degree of sulfonation of more than 50%, especially about 70%, more preferably 80% and greater used.

• (i) Umsetzung des mindestens einen Polyaryletherketons mit mindestens einer Alkansulfonsäure unter Erhalt von Schwefel enthaltenden Polyaryletherketonen (K1).

Very particular preference is given to the use of such sulfonated polyaryl ether ketones which are obtainable by the following process, which may comprise several steps:
Step (i):

• (i) reacting the at least one polyaryletherketone with at least one alkanesulfonic acid to give sulfur-containing polyaryletherketones (K1).

Become in this preparation two or more different polyaryletherketones used together, it is conceivable that only one of the polyaryletherketones is sulfonated. Likewise two or more sulfonated.

Aliphatic sulfonic acids are generally suitable as alkanesulfonic acid. Preference is given to using C ₁ -C ₁₂ -alkanesulfonic acids which may be unbranched or branched.

Prefers are alkanesulfonic acids having 1 to 6 carbon atoms, in particular having 1 to 3 carbon atoms, particularly preferably methane, ethane or propane-1-sulfonic acid, wherein Methanesulfonic acid whole is particularly preferred.

Accordingly, in a preferred embodiment, the present invention relates to cosmetic preparations in which sulfonated polyaryletherketones obtainable by the aforementioned process, wherein the alkanesulfonic acid is methanesulfonic acid and the polyaryletherketone is a polyetheretherketone.

When solvent is generally at least one alkanesulfonic acid or a mixture of different alkanesulfonic used. Preferably, in step (i) for the reaction with alkanesulfonic acid used in the polyaryletherketone, particularly preferably methane, used. This means that preferably the min least one alkanesulfonic acid itself as a solvent acts. Suitable alkanesulfonic acids are mentioned above.

The Polyaryletherketone can be used in the reaction in any suitable forms introduced become. Preferably, the polyetheretherketone is used as a powder. If step (i) is carried out in one or more solvents, so the polyaryletherketone before the reaction with the at least an alkanesulfonic acid in at least one alkanesulfonic acid solved or suspended and reacted with the at least one alkanesulfonic acid become.

Prefers will the implementation according to step (i) at temperatures in the range of 15 to 90 ° C, more preferably in the range from 25 to 70 ° C and most preferably carried out in the range of 30 to 50 ° C. Basically it is conceivable, the temperature in the course of the reaction constant to keep or to change continuously or in discrete stages. Prefers the temperature is kept constant during the course of the reaction.

The Reaction according to (i) becomes preferably in a period in the range of 1 to 25 hours, more preferably in the range of 2 to 20 hours and more preferably in one Period of 4 to 16 hours.

The Implementation according to step (i) is at temperatures in the range of 15 to 90 ° C in a Period of 2 to 20 hours.

The Reaction according to (i) becomes preferably under atmospheric pressure carried out. It is the same in principle also possible while the implementation to set a different than atmospheric pressure. During the Implementation, the pressure can be kept constant or continuously or change discreetly.

The molar ratio the reaction partner according to (i) essentially arbitrary. In the reaction according to (i) becomes while a molar ratio of polyaryletherketone to be sulfonated to alkanesulfonic acid in the range from generally 1: 1 to 1: 1000, preferably from 1: 2 to 1 : 500, and more preferably from 1:10 to 1: 300. in the Generally, at least one of the alkanesulfonic acids will be in excess used.

Becomes the alkanesulfonic acid at the same time as a solvent used, it is in molar excess in relation to Polyaryletherketone ago.

preferred sulfonated polyaryletherketones are according to the aforementioned method available, wherein the reaction in step (i) is carried out such that the preferred at the same time as a solvent used alkanesulfonic acid in a reactor with the polyaryletherketone added with stirring becomes. It is about the above period in the above-mentioned reaction conditions further stirred. The resulting sulfur-containing polyaryletherketone can after isolated methods known in the art.

Prefers however, no isolation of the sulfur-containing polyaryletherketone occurs, but a reaction with at least one further sulfonating agent to obtain sulfonated polyaryletherketones (K2) in one further process step (ii). The process step (ii) can doing in the same reactor or in a different reactor than the Process step (i) performed become.

Under a "sulfur containing polyaryletherketone "is while a polyaryletherketone to understand that bound sulfur contains. This must not or not exclusively in the form of sulfonic acid groups available.

The sulfur content of sulfur-containing polyaryl ether ketones, preferably of PEEK ^® - and (. Plc by Victrex) PEK ^® -Polymertypen is generally from 0.10 to 8.7 wt .-% (PEEK) or from 0.16 to 11.6 Wt .-% (PEK) preferably 4 to 8 wt .-% (PEEK) or 5.6 to 10.8 (PEK), determined by elemental analysis.

in the Case that the total sulfur content of the sulfur-containing Polyaryletherketone on sulfonic acid groups based, possess the sulfur-containing polyaryletherketones of the PEEK polymer type sulfonation degrees of 10 to 100%, preferably over 78%, more preferably 80% and above.

For the use in the cosmetics preferred sulfonated polyaryletherketones are obtainable by a process which is characterized in that the step (i) a Sulfonation step (ii) followed, in which the degree of sulfonation obtained according to (i) Sulfur-containing polyaryletherketones (K1) is adjusted.

Does that happen? produced according to (i) Sulfur-containing polyaryletherketone (K1) in the optionally as solvent used alkanesulfonic acid on, so it is possible the according to step (i) solution obtained directly in step (ii). Likewise, an exchange of solvents conceivable. The solution of the at least one polyaryletherketone obtained from (i) is preferred (K1) in the at least one alkanesulfonic acid directly in step (ii) used.

While it in principle possible is, from (i) obtained sulfur containing polyaryletherketone according to (ii) or several times with at least one alkanesulfonic acid as To implement sulfonating agent, it is particularly advantageous in (ii) use at least one sulfonating agent other than alkanesulfonic acids is. In principle, all are known from the prior art and by way of example already above described sulfonating agent such as oleum among other concentrated Sulfuric acid, highly concentrated (i.e., about 98%) sulfuric acid, sulfur trioxide, or chlorosulfonic acid in at least a suitable organic solvent or butyllithium together with sulfur dioxide with following Oxidation using, for example, potassium permanganate einsetzbar.

For the use in cosmetic and oral care products Very particularly preferred sulfonated polyaryl ether ketones are accordingly available, a polyetheretherketone in at least two steps sulfuric functionalized and sulfonated, treatment with alkanesulfonic acid as Pretreatment step, which is a Sulfonierungsschritt followed.

On that way the desired one Setting the degree of sulfonation of the polyaryl ether ketone particularly simple.

As already described above, the solution preferably obtained in step (i) is preferably used directly in step (ii). In a particularly preferred embodiment, this solution according to (ii) is brought into contact with oleum having an SO ₃ content of about 25% or highly concentrated (about 98%) sulfuric acid as the sulfonating agent.

Accordingly, the present invention also provides the use of sulfonated polyaryl ether ketones in cosmetic preparations by a method as described above Method available characterized in that as the at least one Sulfonating agent Oleum is used.

ever after desired Degree of sulfonation achieved according to (ii) should be able to the reaction parameters of step (ii) are adjusted.

One particular advantage of the method is the fact that after pretreatment by means of alkanesulfonic acid according to (i) with adjustment of comparatively easy to influence reaction parameters such Temperature, reaction time and concentration of the sulfonating agent, preferably oleum and highly concentrated (about 98%) sulfuric acid, the "degree of sulfonation" of the sulfonated Polyaryletherketone (K2) reproducible in wide ranges, in particular in the range of 10 to 90%, is adjustable. The different "degrees of sulfonation" of the polyaryl ether ketones in particular by the concentration of the sulfonating agent controlled.

With Help of the method is thus a rapid sulfonation of polyaryletherketones possible, preferably a narrow distribution of the "degree of sulfonation" is achieved The process comprising steps (i) and (ii) may comprise sulfonated Polyaryl ether ketones are obtained which have a "degree of sulfonation" in the range of 10 to 90.

object the invention is therefore the use of the aforementioned Method available sulfonated polyaryletherketones having a degree of sulfonation greater than 50%, preferably greater than 70%, more preferably 80% and larger. Basically, it is conceivable that Keep temperature constant throughout the reaction or continuously or change in discrete stages. Preferably, the temperature is kept constant during the course of the reaction. The sulfonation according to (ii) becomes in this case preferably under atmospheric pressure carried out.

in the general is according to the aforementioned Method to obtain the sulfonated polyaryletherketone in solution, particularly preferably in the at least used in step (i) an alkanesulfonic acid. It is basically conceivable to use the sulfonated polyaryletherketone in solution. Likewise is a solvent exchange conceivable according to a suitable method. Similarly, the sulfonated Polyaryletherketone according to one suitable, known in the art process from the solution isolated be used in its field of application. Prefers the isolation of the sulfonated polyaryletherketone takes place the solution preferably obtained the at least one alkanesulfonic acid used in step (i) precipitate in ice water, washing and drying, the sulfonated polyaryletherketone generally in the form of powder, granules or fibers will, depending from the isolation step.

neutralization the sulfonated polyaryletherketones

object The invention furthermore relates to the use of the sulfonated polyaryl ether ketones in partial or complete neutralized form by the reaction with organic or inorganic bases is obtained.

in principle are neutralizing agents all bases suitable with which the sulfonated polyaryletherketones cosmetically, dermatologically and / or form pharmaceutically acceptable salts.

• – einem Mono-, Di- oder Trialkanolamin mit 2 bis 5 Kohlenstoffatomen im Alkanolrest, der gegebenenfalls in veretherter Form vorliegt, beispielsweise Mono-, Di- und Triethanolamin, Mono-, Di- und Tri-n-propanolamin, Mono-, Di- und Triisopropanolamin, 2-Amino-2-methylpropanol und Di(2-methoxyethyl)amin,
• – einem Alkandiolamin mit 2 bis 5 Kohlenstoffatomen, beispielsweise 2-Amino-2-methylpropan-1,3-diol und 2-Amino-2-ethylpropan-1,3-diol, oder
• – einem primären, sekundären oder tertiären Alkylamin mit insgesamt 5 bis 10 Kohlenstoffatomen, beispielsweise N,N-Diethylpropylamin oder 3-Diethylamino-1-propylamin.

The neutralization is advantageous with

• A mono-, di- or trialkanolamine having 2 to 5 carbon atoms in the alkanol radical, which is optionally present in etherified form, for example mono-, di- and triethanolamine, mono-, di- and tri-n-propanolamine, mono-, di-, and triisopropanolamine, 2-amino-2-methylpropanol and di (2-methoxyethyl) amine,
• An alkanediolamine having 2 to 5 carbon atoms, for example 2-amino-2-methylpropane-1,3-diol and 2-amino-2-ethylpropane-1,3-diol, or
• A primary, secondary or tertiary alkylamine having a total of 5 to 10 carbon atoms, for example N, N-diethylpropylamine or 3-diethylamino-1-propylamine.

Become frequent good neutralization results with 2-amino-2-methylpropanol, triisopropanolamine, 2-amino-2-ethylpropane-1,3-diol or 3-diethylamino-1-propylamine.

Especially Triethanolamine is preferably used for neutralization.

When Alkali metal hydroxides are suitable for neutralization, especially sodium, or potassium and ammonium hydroxide.

In a preferred embodiment, the sulfonated polyaryl ether ketones are neutralized with MOH, wherein M is selected from alkali metals or ammonium (NH ₄ ⁺ , monoalkylammonium, dialkylammonium, trialkylammonium and tetraalkylammonium ions), preferably from the group consisting of Li, Na, K, NH ₄ , more preferably from the group Na, K, NH ₄ .

In a further preferred embodiment become the sulfonated polyaryletherketones with corresponding hydroxides of cosmetically, dermatologically and / or pharmaceutically acceptable neutralized di- or trivalent metals. Preferred are the cosmetically, dermatologically and / or pharmaceutically acceptable hydroxides the metals of the 2nd and 3rd main group of the Periodic Table of the Elements. In particular, the hydroxides of Mg, Ca and Al may be mentioned.

Farther are suitable for neutralization aqueous Buffer solutions, such as buffers based on alkali or ammonium carbonate or bicarbonate.

The Neutralizing agents are preferably used as a dilute aqueous solution. Preference is given to the use of sulfonated polyaryl ether ketones, partially or completely be neutralized.

Degree of neutralization and neutralizing agents significantly affect the solubility and the mechanical properties of the solutions of the sulfonated and / or Sulfur-containing polyaryl ether ketones produced films.

For example have films made from calcium hydroxide neutralized sulfonated Polyaryletherketone are produced, other mechanical properties, for example, a larger modulus of elasticity as films made from triethanolamine neutralized sulfonated Polyaryletherketone be prepared.

Accordingly, according to the invention the solubility the sulfonated polyaryletherketones and the mechanical properties the one from the solutions producible films by the degree of neutralization and the choice of adjusted for neutralization neutralizing agent adjusted become.

The hang mechanical properties accordingly also on the nature of the counterions. Especially advantageous It is, therefore, the mechanical properties by the choice of To influence counterions.

cosmetic preparations

In the cosmetic according to the invention Preparations are the sulfonated polyaryletherketones advantageous in dissolved Form before. As a solvent come water, on and Polyhydric alcohols and mixtures thereof into consideration.

preferred solvent are water, ethanol, n-propanol, i-propanol, n-butanol, butan-2-ol, 2-methylpropan-1-ol, 2-methylpropan-2-ol, propylene glycol, glycerol, Sorbitol and mixtures thereof.

In a particularly preferred embodiment is the solvent selected from the group consisting of water, ethanol, i-propanol and mixtures it.

The cosmetic according to the invention Compositions containing sulfonated polyaryletherketones can be used as aqueous or aqueous-alcoholic Solutions, O / W and W / O emulsions in the form of shampoos, creams, foams, sprays (pump spray or Aerosol), gels, gel sprays, lotions or mousses, and accordingly with usual be formulated further excipients.

additions

The cosmetic preparations in addition to the sulfonated polyaryletherketones and suitable solvents additives customary in such formulations, emulsifiers and coemulsifiers, Surfactants, oils, preservatives, Perfume oils, cosmetic Care and active ingredients such as AHA acids, Fruit acids, Ceramides, phytantriol, collagen, vitamins and provitamins, for example Vitamin A, E and C, retinol, bisabolol, panthenol, natural and synthetic light stabilizers, natural substances, opacifiers, solubilizers, Repellents, bleaches, dyes, Tints, tanning agents (e.g., dihydroxyacetone), micropigments such as titanium oxide or zinc oxide, superfatting agents, Pearlescent waxes, bodying agents, thickeners, solubilizers, complexing agents, Fats, waxes, silicone compounds, hydrotropes, dyes, stabilizers, pH Regulators, reflectors, proteins and protein hydrolysates (e.g. Wheat, almond or pea proteins), ceramide, protein hydrolysates, Salts, gelling agents, bodying agents, silicones, humectants, refatting and more usual ones Contain additives. Furthermore, to adjust each desired Properties in particular also contain other polymers.

To the Protecting the skin and hair from UV rays can also contain UV light stabilizers in the cosmetic preparations be. examples for the respective classes of excipients are mentioned below, without the possible To limit excipients to those exemplified.

Usual additives for cosmetic Preparations are the expert, for example, from W. Umbach, "cosmetics", 2nd edition, Thieme-Verlag 1995, ISBN 3-13-712602-9 known.

cleaning of the skin

According to the invention, the sulfonated polyaryl ether ketones are used, for example, in cosmetic preparations for cleansing the skin. Such cosmetic cleansers are selected from bar soaps such as toilet soaps, core soaps, transparent soaps, luxury soaps, de-soaps, cream soaps, baby soaps, skin protective soaps, abrasive soaps and syndets, liquid soaps such as pasty soaps, greases and washing pastes, and liquid washing, shower and bath preparations such as washing lotions, shower gels and baths, bubble baths, oil baths and scrub preparations.

care and Protection of the skin

Prefers become the sulfonated polyaryletherketones in cosmetic products for the care and protection of the skin, in nail care products as well in preparations for the decorative cosmetics applied.

Especially preferred is the use in skin care products, personal care products, Foot care products, deodorants, Sunscreens, repellents, shaving, hair removal products, Anti-aches, makeup, mascara, lipsticks, eyeshadows, kohl pencils, Eyeliners, rouges, powders and eyebrow pencils.

The Skin care products are in particular as W / O or O / W skin creams, Day and night creams, eye creams, face creams, anti-wrinkle creams, Moisturizing creams, bleaching creams, vitamin creams, skin lotions, skin lotions and moisturizing lotions.

In the cosmetic preparations the sulfonated polyaryl ether ketones have particular effects. The sulfonated polyaryletherketones can, inter alia, for moisturization and condition the skin and improve the skin feel. The sulfonated polyaryl ether ketones can also be used as thickeners in act on the formulations. By addition of sulfonated polyaryletherketones In certain formulations, a significant improvement in the skin compatibility be achieved.

The sulfonated polyaryletherketones are in the skin cosmetic preparations in a proportion of about 0.001 to 20% by weight, preferably 0.01 to 10 wt .-%, most preferably 0.1 to 5 wt .-%, based on the total weight of the agent.

object Accordingly, the invention also cosmetic compositions containing sulfonated Polyaryletherketones.

ever according to application the agents according to the invention in a form suitable for skin care, e.g. as a cream, foam, Gel, pen, powder, mousse, milk or lotion can be applied.

The skin cosmetic preparations in addition to the sulfonated polyaryletherketones and suitable solvents even more common in cosmetics Additions, such as emulsifiers, preservatives, perfume oils, cosmetic agents such as phytantriol, vitamins A, E and C, retinol, bisabolol, panthenol, Light stabilizers, bleaching agents, colorants, tinting agents, tanning agents (e.g., dihydroxyacetone), collagen, protein hydrolysates, stabilizers, pH regulators, dyes, salts, thickeners, gelling agents, bodying agents, Silicones, humectants, moisturizers and more usual ones Contain additives.

Other common additives may include fatty substances such as mineral and synthetic oils such as paraffins, silicone oils and aliphatic hydrocarbons having more than 8 carbon atoms, animal and vegetable oils such as sunflower oil, coconut oil, avocado oil, olive oil, lanolin, or waxes, fatty acids , Fatty acid esters such as triglycerides of C ₆ -C ₃₀ fatty acids, wax esters such as jojoba oil, fatty alcohols, petrolatum, hydrogenated lanolin and acetylated lanolin. Of course, mixtures thereof may also be used.

Common thickener in such formulations are crosslinked polyacrylic acids and their derivatives, polysaccharides such as xanthan gum, agar-agar, alginates or tyloses, carboxymethylcellulose or hydroxycarboxymethylcellulose, Fatty alcohols, monoglycerides and fatty acids, polyvinyl alcohol and Polyvinylpyrrolidone.

Of course, the cosmetic, in particular skin-cosmetic preparations in addition to the sulfonated polyaryletherketones further conventional Contain polymers to certain properties and effects of To achieve preparations.

When conventional Polymers are, for example, anionic, cationic, amphoteric and neutral polymers.

Examples of anionic polymers are homopolymers and copolymers of acrylic acid and methacrylic acid or their salts, copolymers of acrylic acid and acrylamide and their salts; Sodium salts of polyhydroxycarboxylic acids, water-soluble or water-dispersible polyesters, polyurethanes and polyureas. Particularly suitable polymers are copolymers of t-butyl acrylate, ethyl acrylate, methacrylic acid (eg Luvimer ^™ 100P), copolymers of ethyl acrylate and methacrylic acid (eg Luvimer ^™ MAE), copolymers of N-tert-butylacrylamide, ethyl acrylate, acrylic acid (Ultrahold ^™ 8 , strong), copolymers of vinyl acetate, crotonic acid and optionally further vinyl esters (eg Luviset ^™ brands), maleic anhydride copolymers, optionally reacted with alcohols, anionic polysiloxanes, for example carboxy-functional, copolymers of vinylpyrrolidone, t-butyl acrylate, methacrylic acid (eg Luviskol ^™ VBM), copolymers of acrylic acid and methacrylic acid with hydrophobic monomers, such as C ₄ -C ₃₀ -alkyl esters of meth (acrylic acid), C ₄ -C ₃₀ -Alkylvinylester, C ₄ -C ₃₀ -alkyl, and hyaluronic acid, Luviset ^® PUR, Luviflex Silk ^®.

Further suitable polymers are cationic polymers with the name Polyquaternium according to INCI, eg copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat ^™ FC, Luviquat ^™ HM, Luviquat ^™ MS, Luviquat ^™ Care, Luviquat ^™ Hold, INCI Polyquaternium-16, -44, -46), copolymers of acrylamide and dimethyldiallylammonium chloride (Polyquaternium-7), cationic cellulose derivatives (Polyquaternium-4, -10), cationic starch derivatives (INCI: Starch Hydroxypropytrimonium Chloride, Corn Starch Modified), cationic guar derivatives (INCI: Hydroxypropyl Guar Hydroxypropyltrimonium Chloride) , cationic sunflower oil derivatives (INCI: Sunflowerseedamidopropyl Hydroxyethyldimonium Chloride), copolymers of N-vinylpyrrolidol / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Polyquaternium-11), copolymers of acrylic acid, acrylamide and methacrylamidopropyltrimonium chloride (Polyquaternium-53), Polyquaternium-32, Polyquaternium-28 and other.

Also suitable as other polymers are neutral polymers, such as polyvinylpyrrolidones, copolymers of N-vinylpyrrolidone and vinyl acetate and / or vinyl propionate, copolymers of N-vinylpyrrolidone / dimethylaminopropylacrylamide or -methacrylamide, copolymers of N-vinylpyrrolidone and alkyl acrylate or methacrylate monomers with alkyl chains of C ₁ to C ₁₈ , graft copolymers of polyvinyl alcohol on polyalkylene glycols such as Kollicoat ^® IR (BASF), graft copolymers of other vinyl monomers on polyalkylene glycols, polysiloxanes, polyvinylcaprolactam and copolymers with N-vinylpyrrolidone, polyethyleneimines and their salts, polyvinylamines and their salts, cellulose derivatives, chitosan, polyaspartic acid salts and derivatives.

to Setting certain properties, the preparations may also be Contain conditioning substances based on silicone compounds. Suitable silicone compounds are, for example, polyalkylsiloxanes, Polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes, silicone resins, Dimethicones, dimethicone derivatives or dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA).

The sulfonated polyaryletherketones are used in cosmetic preparations used, their preparation according to the usual familiar to the expert rules he follows. The sulfonated polyaryletherketones are used for the preparation the cosmetic preparations are preferably provided in dissolved form. Especially the sulfonated polyaryletherketones are in aqueous solution or in aqueous / alcoholic Solution, especially preferably in aqueous solution provided.

Such Formulations are advantageously in the form of emulsions preferred as water-in-oil (W / O) - or oil-in-water (O / W) emulsions in front. However, it is also possible according to the invention and if appropriate advantageous, to choose other types of formulations, for example, hydrodispersions, gels, oils, oleogels, multiple emulsions, for example in the form of W / O / W or O / W / O emulsions, anhydrous Ointments or ointment bases etc.

The Preparation Usable According to the Invention Emulsions are carried out by known methods.

The Emulsions contain, in addition to the sulfonated polyaryl ether ketones, customary constituents, such as fatty alcohols, fatty acid esters and in particular fatty acid triglycerides, fatty acids, lanolin and derivatives thereof, natural or synthetic oils or waxes and emulsifiers in the presence of water.

The Selection of emulsion type-specific additives and the preparation of suitable Emulsions are described, for example, in Schrader, Grundlagen and recipes of cosmetics, Hüthig Book publishing house, Heidelberg, 2nd edition, 1989, third part, what hereby expressly Reference is made.

For example, a skin cream which can be used according to the invention can be present as a W / O emulsion. Such an emulsion contains an aqueous phase which by means of a suitable emulsifier system in an oil or Fat phase is emulsified.

The concentration of the emulsifier system in this emulsion type is about 4 and 35% by weight, based on the total weight of the emulsion; the fatty phase constitutes about 20 and 60% by weight and the aqueous phases about 20 and 70% by weight, based in each case on the total weight of the emulsion. The emulsifiers are those which are commonly used in this type of emulsion. They are selected, for example, from: C ₁₂ -C ₁₈ sorbitan fatty acid esters; Esters of hydroxystearic acid and C ₁₂ -C ₃₀ fatty alcohols; Monoesters and diesters of C ₁₂ -C ₁₈ fatty acids and glycerine or polyglycerol; Condensates of ethylene oxide and propylene glycols; oxypropylenated / oxyethylenated C ₁₂ -C ₂₀ fatty alcohols; polycyclic alcohols, such as sterols; high molecular weight aliphatic alcohols such as lanolin; Mixtures of oxypropylenated / polyglycerinated alcohols and magnesium isostearate; Succinic esters of polyoxyethylenated or polyoxypropylenated fatty alcohols; and mixtures of magnesium, calcium, lithium, zinc or aluminum lanolate and hydrogenated lanolin or lanolin alcohol.

To suitable fat components which are in the fatty phase of the emulsions can be included counting Hydrocarbon oils, like paraffin oil, purCellin, Perhydrosqualene and solutions microcrystalline waxes in these oils; animal or vegetable oils, such as Sweet almond oil, avocado oil, calophilum oil, lanolin and derivatives thereof, castor oil, Sesame oil, Olive oil, jojoba oil, Sheathing oil, hoplostethus oil; mineral oils whose Start of distillation under atmospheric pressure at about 250 ° C and their Distillation endpoint at 410 ° C is such as vaseline oil; Saturated esters or unsaturated fatty acids, such as alkyl myristates, e.g. i-propyl, butyl or cetyl myristate, hexadecyl stearate, Ethyl or i-propyl palmitate, octanoic or decanoic acid triglycerides and cetyl ricinoleate.

The Fat phase can also be found in other oils soluble Silicone oils, such as dimethylpolysiloxane, methylphenylpolysiloxane and the silicone glycol copolymer, fatty acids and fatty alcohols.

Around the retention of oils to favor, it is also possible to use waxes, e.g. Carnauba wax, candellila wax, Beeswax, microcrystalline wax, ozokerite wax and Ca, Mg and Al oleates, myristates, linoleates and stearates.

in the In general, these water-in-oil emulsions are prepared that the fat phase and the emulsifier are added to the batch tank become. You warm up this at a temperature of 70 to 75 ° C, then gives the oil-soluble Ingredients too and adds with stirring Add water, which was previously heated to the same temperature and wherein the water-soluble Ingredients solved before Has; one stirs, until you get an emulsion of the desired Has fineness, lets then cool to room temperature, optionally with less stirring becomes.

Farther may be a care emulsion according to the invention as O / W emulsion. Such an emulsion usually contains an oil phase, Emulsifiers containing the oil phase stabilize in the water phase, and an aqueous phase, usually thickened present.

• – Alkohole, Diole oder Polyole sowie deren Ether, vorzugsweise Ethanol, Isopropanol, Propylenglycol, Glycerin, Ethylenglycolmonoethylether;
• – übliche Verdickungsmittel bzw. Gelbildner, wie z.B. vernetzte Polyacrylsäuren und deren Derivate, Polysaccharide wie Xanthan Gum oder Alginate, Carboxymethylcellulose oder Hydroxycarboxymethylcellulose, Fettalkohole, Polyvinylalkohol und Polyvinylpyrrolidon.

The aqueous phase of the O / W emulsion of the preparations according to the invention optionally contains

• - Alcohols, diols or polyols and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol monoethyl ether;
• Customary thickeners or gelling agents, for example crosslinked polyacrylic acids and their derivatives, polysaccharides, such as xanthan gum or alginates, carboxymethylcellulose or hydroxycarboxymethylcellulose, fatty alcohols, polyvinyl alcohol and polyvinylpyrrolidone.

• – Ester aus gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkancarbonsäuren und gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkoholen, aus aromatischen Carbonsäuren und gesättigten und/oder ungesättigten, verzweigten und/oder unverzweigten C₃-C₃₀-Alkoholen, beispielhaft Isopropylmyristat, Isopropylstearat, Hexyldecylstearat, Oleyloleat; außerdem synthetische, halbsynthetische und natürliche Gemische solcher Ester, wie Jojobaöl;
• – verzweigte und/oder unverzweigte Kohlenwasserstoffe und -wachse;
• – Silikonöle wie Cyclomethicon, Dimethylpolysiloxan, Diethylpolysiloxan, Octamethylcyclotetrasiloxan sowie Mischungen daraus;
• – Dialkylether;
• – Mineralöle und Mineralwachse;
• – Triglyceride gesättigter und/oder ungesättigter, verzweigter und/oder unverzweigter C₈-C₂₄-Alkancarbonsäuren; sie können ausgewählt werden aus synthetischen, halbsynthetischen oder natürlichen Ölen, wie Olivenöl, Palmöl, Mandelöl oder Mischungen.

The oil phase contains in cosmetics conventional oil components, such as:

• Esters of saturated and / or unsaturated, branched and / or unbranched C ₃ -C ₃₀ -alkanecarboxylic acids and saturated and / or unsaturated, branched and / or unbranched C ₃ -C ₃₀ -alcohols, of aromatic carboxylic acids and saturated and / or unsaturated branched and / or unbranched C ₃ -C ₃₀ -alcohols, for example isopropyl myristate, isopropyl stearate, hexyldecyl stearate, oleyl oleate; also synthetic, semi-synthetic and natural mixtures of such esters as jojoba oil;
• - branched and / or unbranched hydrocarbons and waxes;
• - Silicone oils such as cyclomethicone, dimethylpolysiloxane, diethylpolysiloxane, octamethylcyclotetrasiloxane and mixtures thereof;
• - dialkyl ethers;
• - mineral oils and mineral waxes;
• Triglycerides of saturated and / or unsaturated, branched and / or unbranched C ₈ -C ₂₄ -alkanoic carbon acids; they can be selected from synthetic, semi-synthetic or natural oils, such as olive oil, palm oil, almond oil or mixtures.

When Emulsifiers are preferably O / W emulsifiers, such as polyglycerol esters, Sorbitan esters or partially esterified glycerides.

The Production can be carried out by melting the oil phase at about 80 ° C; the water-soluble Ingredients become in hot Solved water, slowly and with stirring to the oil phase added; homogenized and cold-stirred.

The According to the invention, sulfonated polyaryl ether ketones are also suitable for Use in washing and shower gel formulations and bath preparations.

Such Formulations usually contain in addition to the sulfonated polyaryletherketones anionic surfactants as base surfactants and amphoteric and nonionic Surfactants as cosurfactants, as well as lipids, perfume oils, dyes, organic acids, Preservatives and antioxidants as well as thickeners / gelling agents, Skin conditioners and moisturizers.

In the washing, shower and bath preparations can all in body cleansers usually used anionic, neutral, amphoteric or cationic surfactants be used.

The Formulations contain from 2 to 50% by weight of surfactants, preferably from 5 to 40 wt .-%, particularly preferably 8 to 30% by weight.

suitable anionic surfactants are, for example, alkyl sulfates, alkyl ether sulfates, Alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-alkoylsarcosinates, alkyl glycol alkoxylates, acyl taurates, acyl isethionates, Alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, alpha olefin sulfonates, in particular the alkali and Alkaline earth metal salts, e.g. Sodium, potassium, magnesium, calcium, and ammonium and triethanolamine salts. The alkyl ether sulfates, Alkyl ether phosphates and alkyl ether carboxylates can be between 1 to 10 ethylene oxide or propylene oxide units, preferably 1 to 3 ethylene oxide units in the molecule.

Suitable For example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, Ammonium lauryl ether sulfate, sodium lauryl sarcosinate, sodium oleyl succinate, Ammonium laurylsulfosuccinate, sodium dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate.

suitable amphoteric surfactants are, for example, alkylbetaines, alkylamidopropyl betaines, Alkylsulfobetaines, alkylglycinates, alkylcarboxyglycinates, alkylamphoacetates or propionates, alkyl amphodiacetates, or dipropionates.

For example can Cocodimethyl sulphopropyl betaine, lauryl betaine, cocamidopropyl betaine or sodium cocamphopropionate.

When Nonionic surfactants are suitable, for example, the reaction products of aliphatic alcohols or alkylphenols having 6 to 20 C atoms in the alkyl chain, which may be linear or branched, with ethylene oxide and / or propylene oxide. The amount of alkylene oxide is about 6 up to 60 moles per one mole of alcohol. Furthermore, alkylamine oxides, mono- or dialkylalkanolamides, fatty acid esters of polyethylene glycols, ethoxylated fatty acid amides, alkyl polyglycosides or sorbitan ether esters.

In addition, the Washing, shower and bath preparations usual cationic Surfactants, e.g. quaternary ammonium compounds, for example Cetyltrimethylammonium chloride or bromide (INCI Cetrimonium Chloride or bromide), hydroxyethyl cetyldimonium phosphate (INCI Quaternium-44), INCI cocotrimonium methosulfate, INCI Quaternium-52.

In addition, it is also possible to use other customary cationic polymers, for example copolymers of acrylamide and dimethyldiallylammonium chloride (Polyquaternium-7), cationic cellulose derivatives (Polyquaternium-4, -10), cationic starch derivatives (INCI: Starch hydroxypropytrimonium chloride, Corn Starch Modified), cationic guar derivatives (INCI: hydroxypropyl guar hydroxypropyltrimonium chlorides), cationic sunflower oil derivatives (INCI: Sunflowerseedamidopropyl hydroxyethyldimonium chlorides), copolymers of N-vinylpyrrolidone and quaternized N-vinylimidazole (Polyquaternium-16, -44, -46), copolymers of N-Vinypyrrolidone / dimethylaminoethyl methacrylate quaternized with diethyl sulfate (Polyquaternium-11), copolymers of acrylic acid, acrylamide and methacrylamidopropyltrimonium chloride (Polyquaternium-53), Polyquaternium-32, Polyquaternium-28 and others.

Farther can Wash and Shower Gel Formulations and Bath Preparations Thicken, e.g. Saline, PEG-55, Propylene Glycol Oleate, PEG-120 Methyl Glucose Dioleate and others, as well as preservatives, other active ingredients and excipients and water included.

hair cosmetic preparations

hair cosmetic Preparations comprise, in particular, styling agents and / or conditioning agents in hair cosmetic preparations such as hair treatments, hair foams (engl. Mousses), (hair) gels or hairsprays, hair lotions, hair conditioners, Hair shampoos, hair emulsions, top fluids, leveling agents for perms, hair coloring and bleaching agents, "hot oil treatment" preparations, Conditioners, setting lotions or hair sprays. Depending on the application can the hair cosmetic preparations as (aerosol) spray, (aerosol) foam, Gel, gel spray, cream, lotion, milk or wax are applied.

One further subject of the invention are thus cosmetic agents, wherein the agent is present as a gel, milk, cream, lotion or foam. In particular, the agent is present as a gel or foam.

Prefers the agent is a product for the hair which is under the shampoo and Products for the hair selected is that rinsed out or not rinsed out and before or after shampooing, coloring, decolorization, perming or wrinkling be applied.

Also according to the invention a method of treating hair, characterized that the Hair containing the cosmetic agent containing a sulfonated polyaryletherketone, be brought into contact and optionally rinsed with water.

• a) 0,05 bis 20 Gew.-% der sulfonierten Polyaryletherketone
• b) 20 bis 99,95 Gew.-% Wasser und/oder Alkohol
• c) 0 bis 79,5 Gew.-% weitere Bestandteile

The hair cosmetic preparations of the invention comprise in a preferred embodiment

• a) 0.05 to 20 wt .-% of the sulfonated polyaryletherketones
• b) 20 to 99.95% by weight of water and / or alcohol
• c) 0 to 79.5 wt .-% further ingredients

Under Alcohol are all alcohols commonly used in cosmetics, e.g. Ethanol, isopropanol, n-propanol.

Under other constituents are the additives customary in cosmetics, for example propellants, defoamers, surfactants Compounds, i. Surfactants, emulsifiers, foaming agents and solubilizers. The used surface-active Connections can anionic, cationic, amphoteric or neutral. Other common ingredients can further, e.g. Preservatives, perfume oils, plasticizers, effect substances, Opacifiers, Active ingredients, antioxidants, peroxide decomposers, UV filters, care agents such as panthenol, collagen, vitamins, protein hydrolysates, alpha and beta hydroxycarboxylic acids, protein hydrolysates, Stabilizers, pH regulators, Dyes, pigments, viscosity regulators, Gel formers, salts, humectants, moisturizers, complexing agents and more usual Additives.

Styling and Conditionerpolymere

Farther counting for this purpose all known in cosmetics styling and conditioner polymers, used in combination with the polymers of the invention can be if very special properties should be set.

When conventional Polymers are, for example, anionic, cationic, amphoteric and neutral polymers.

• – Copolymere aus tert.-Butylacrylat, Ethylacrylat und Methacrylsäure
• – Copolymere aus Ethylacrylat und Methacrylsäure
• – Copolymere aus N-tert.-Butylacrylamid, Ethylacrylat und Acrylsäure
• – Polyvinylpyrrolidone
• – Polyvinylcaprolactame
• – Polyurethane, wie beispielsweise in WO 94/03510 beschrieben
• – Polyharnstoffe
• – Polyamide
• – Copolymere aus Acrylsäure, Methylmethacrylat, Octylacrylamid, Butylaminoethylmethylacrylat und Hydroxypropylmethacrylat,
• – Copolymere aus Vinylacetat und Crotonsäure und/oder (Vinyl)-Neodecanoat,
• – Copolymere aus Vinylacetat und/oder Vinylpropionat und N-Vinylpyrrolidon,
• – carboxyfunktionelle Copolymere aus Vinylpyrrolidon, t-Butylacrylat, Methacrylsäure,
• – Copolymere aus tert.-Butylacrylat, Methacrylsäure und Dimethicone Copolyol.

Preferred examples of such further polymers are

• - Copolymers of tert-butyl acrylate, ethyl acrylate and methacrylic acid
• - Copolymers of ethyl acrylate and methacrylic acid
• - Copolymers of N-tert-butylacrylamide, ethyl acrylate and acrylic acid
• - Polyvinylpyrrolidones
• - Polyvinylcaprolactams
• - Polyurethanes, as described for example in WO 94/03510
• - polyureas
• - polyamides
• Copolymers of acrylic acid, methyl methacrylate, octylacrylamide, butylaminoethylmethyl acrylate and hydroxypropyl methacrylate,
• Copolymers of vinyl acetate and crotonic acid and / or (vinyl) neodecanoate,
• Copolymers of vinyl acetate and / or vinyl propionate and N-vinylpyrrolidone,
• Carboxy-functional copolymers of vinylpyrrolidone, t-butyl acrylate, methacrylic acid,
• - Copolymers of tert-butyl acrylate, methacrylic acid and dimethicone copolyol.

Surprisingly It has been found that preparations containing the sulfonated polyaryl ether ketones in combination with these other polymers contain unexpected Have properties. The preparations according to the invention are in particular in terms of their skin and hair care properties of the preparations superior to the prior art. Furthermore, they have very good film-forming and firming properties on.

Copolymers of tert-Buhylacrylat, ethyl acrylate and methacrylic acid (INCI name: Acrylates Copolymer), for example, ^® 36 D, Luvimer ^® 30 E (BASF) as the commercial product Luvimer ^® 100 P, Luvimer.

Copolymers of ethyl acrylate and methacrylic acid (INCI name: Acrylates Copolymer), available, for example, as commercial products Luviflex Soft ^® (BASF).

Copolymers of N-tert-butylacrylamide, ethyl acrylate and acrylic acid (INCI name: Acrylates / Acrylamide Copolymer), for example, are available as commercial products Ultra Hold Strong ^®, Ultrahold 8 ^® (BASF).

Polyvinylpyrrolidone (INCI name: PVP) are, for example, under the trade names Luviskol ^® K, Luviskol ^® K 30 (BASF) Luviskol ^® K17, Luviskol ^® K30, Luviskol ^® K60, Luviskol ^® K80, Luviskol ^® K90 (polyvinylpyrrolidones with corresponding K value as Powder or as a solution (aqueous or aqueous / alcoholic) and PVP K (ISP) available.

Polyvinylcaprolactams (INCI: Polyvinylcaprolactams) are for example available under the trade name Luviskol Plus ^® (BASF).

Polyurethanes (INCI: Polyurethane-1) are for example available under the trade name Luviset ^® PUR.

Copolymers of acrylic acid, methyl methacrylate, octyl acrylamide, Butylaminoethylmethylacrylat, hydroxypropyl methacrylate (INCI: Octylacrylamide / Acrylates / Butylaminoethyl Methacrylate Copolymer) are known for example under the trade name Amphomer ^® 28-4910 and Amphomer ^® LV-71 (National Starch).

Copolymers of vinyl acetate and crotonic acid (INCI: VA / crotonates / copolymer) are available for example under the trade name Luviset CA 66 ^® (BASF), Resyn ^® 28-1310 (National Starch) and Aristoflex ^® A (Celanese).

Copolymers of vinyl acetate, crotonic acid and (vinyl) neodecanoate (INCI: VA / Crotonates / Neodecanoate Copolymer) are available for example under the trade name Resyn ^® 28-2930 (National Starch) and Luviset ^® CAN (BASF).

Copolymers of vinyl acetate and N-vinylpyrrolidone (INCI: PVP / VA) are, for example, under the trade name Luviskol VA ^® (BASF), especially Luviskol ^® VA 73, Luviskol ^® VA 64, Luviskol ^® VA 55, Luviskol ^® VA 37, Luviskol ^® VA 28 and PVP / VA (ISP) available.

Carboxy-functional copolymers of vinylpyrrolidone, t-butyl acrylate, methacrylic acid are obtainable, for example, under the trade name Luviskol ^™ VBM (BASF). Furthermore, suitable as additional polymers, terpolymers of vinylpyrrolidone, vinyl acetate and vinyl propionate, available for example under the name Luviskol ^® VAP 343rd

Copolymers of tert-butyl acrylate, methacrylic acid and dimethicone copolyol are obtainable, for example, under the trade name Luviflex ^™ Silk (BASF). These polymers and their preparation are described in WO 99/04750.

Further suitable polymers for use in the cosmetic preparations according to the invention are homopolymers and copolymers of monoolefinically unsaturated monomers, especially homopolymers and copolymers of C ₁ -C ₁₂ -alkyl acrylates and methacrylates, monoolefinically unsaturated C ₃ -C ₅ -monocarboxylic acids and their vinyl esters, Maleic acid and its monoesters, methyl vinyl ethers, acrylamides, methacrylamides, N-alkyl-substituted (meth) acrylamides, N-vinylpyrrolidone, N-vinylimidazole and styrene.

Suitable further polymers for use in the cosmetic preparations according to the invention are, for example, anionic polymers. Such anionic polymers of the novel (meth) acrylate polymers are various homopolymers and copolymers of acrylic acid and methacrylic acid or salts thereof, copolymers of acrylic acid and acrylamide and their salts, sodium salts of polystyrenesulfonic acid, sodium salts of polyhydroxycarboxylic acids, copolymers of acrylic acid and methacrylic acid with, for example, hydrophobic monomers , for example C ₄ -C ₃₀ -alkyl esters of (meth) acrylic acid, C ₄ -C ₃₀ -Alkylvinylester, C ₄ -C ₃₀ -alkyl and hyaluronic acid and further under the trade names Amerhold ^® DR-25, Ultrahold ^®, Luviset ^® PUR , Acronal ^{®, ®} Acudyne, Lovocryl ^{®, ®} Versatyl, Amphomer ^® (28-4910, LV-71), Placise ^® L53, Flexan ^® 130, Gantrez ^® ES 425, Advantage Plus ^®, Omnirez ^® 2000, Resyn ^® 28- 1310 Resyn ^® 28-2930, balance ^® (0/55), Acydyne ^® 255, Aristoflex ^® A or Eastman AQ ^® balance 47 (National Starch; octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer), Aquaflex FX 64 (ISP; isobutylene / ethylmaleimide / hydroxyethylmaleimide copolymer) Aquaflex ^® SF-40 (ISP / National Starch; VP / vinyl caprolactam / DMAPA acrylate copolymer), Alliance ^® LT-120 (ISP / Rohm &Haas; acrylates / C1-2 succinate / hydroxyacrylate copolymer), Aquarez ^® HS (Eastman, polyester-1), and ^® Diaformer Z-400 ( Clariant; methacryloylethylbetaine / methacrylate copolymer), Diaformer ^® Z-711 or Z-712 (Clariant; methacryloylethyl N-oxide / methacrylate copolymer), Omnirez ^® 2000 (ISP; monoethyl ester of poly (methyl vinyl ether / maleic acid in ethanol), Amphomer ^® HC or Resyn ^® XP or Resyn ^® 28-4961 (National Starch; acrylate / octylacrylamide copolymer), Amphomer ^® 28-4910 (National Starch; octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer), Advantage ^® HC 37 (ISP terpolymer of vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate), Advantage ^® brands (ISP) Acudyne ^® 258 (Rohm &Haas; acrylate / Hydroxyesteracrylat copolymer), Luviset ^® PUR (BASF, polyurethane-1), Luviflex ^® Silk (BASF, PEG / PPG-25 / 25 Dimethicone / Acrylates copolymer), Eastman ^® AQ48 (Eastman), Styleze ^® 2000 (ISP; VP / Ac rylates / Lauryl Methacrylate Copolymer), Styleze CC-10 ^® (ISP; VP / DMAPA Acrylates Copolymer), Styleze ^® W-20 (ISP), Fixomer ^® A-30 (Ondeo Nalco; Methacrylic Acid / Sodium acrylamidomethyl propane sulfonate copolymer), Fixate ^® G-100 (Noveon; AMP-Acrylates / Allyl Methacrylate Copolymer ).
known polymers.

When additional Polymers furthermore suitable are water-soluble or water-dispersible Polyesters, polyureas, co-polyurethaneureas, optionally reacted with alcohols maleic anhydride copolymers or anionic, e.g. carboxy-functional polysiloxanes.

• – Copolymere aus N-Vinylpyrrolidon/N-Vinylimidazoliumsalzen (erhältlich beispielsweise unter den Handelsnamen Luviquat^® FC, Luviquat^® HM, Luviquat^®MS, Luviquat^® Care (BASF),
• – Copolymere aus N-Vinylcaprolactam/N-Vinylpyrrolidon/N-Vinylimidazoliumsalzen (erhältlich beispielsweise unter dem Handelsnamen Luviquat Hold^®),
• – Copolymere aus N-Vinylpyrrolidon/Dimethylaminoethylmethacrylat, quaternisiert mit Diethylsulfat (erhältlich beispielsweise unter dem Handelsnamen Luviquat^® PQ 11),
• – kationische Cellulosederivate (Polyquaternium-4 und -10),
• – Acrylamidcopolymere (Polyquaternium-7),
• – Styleze^® CC-10, Aquaflex^® SF-40,
• – Polyethylenimine und deren Salze,
• – Polyvinylamine und deren Salze Copolymere aus N-Vinylpyrrolidon/Dimethylaminoethylmethacrylat, quaternisiert mit Diethylsulfat (Luviquat^® PQ 11, INCI: Polyquaternium-11),
• – Copolymere aus Acrylamid und Dimethyldiallylammoniumchlorid (Polyquaternium-7),
• – kationische Cellulosederivate (Polyquaternium-4, -10),
• – kationische Stärkederivate (INCI: Starch Hydroxypropytrimonium Chloride, Corn Starch Modified),
• – kationische Guarderivate (INCI: Hydroxypropyl Guar Hydroxypropyltrimonium Chloride),
• – kationische Sonnenblumenöl-Derivate (INCI: Sunflowerseedamidopropyl Hydroxyethyldimonium Chloride),
• – Copolymere aus Acrylsäure, Acrylamid und Methacrylamidopropyltrimoniumchlorid (INCI: Polyquaternium-53),
• – Polyquaternium-32,
• – Polyquaternium-28 und andere.

Other suitable polymers which are furthermore suitable include, for example, cationic polymers with the INCI name Polyquaternium, for example

• - copolymers of N-vinylpyrrolidone / N-vinylimidazolium salts (for example, available under the trade names Luviquat ^® FC, Luviquat ^® HM, Luviquat ^® MS, Luviquat Care ^® (BASF),
• - copolymers of N-vinylcaprolactam / N-vinylpyrrolidone / N-vinylimidazolium salts (for example, available under the trade name Luviquat Hold ^®),
• - copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (available, for example under the trade name Luviquat ^® PQ 11),
• Cationic cellulose derivatives (Polyquaternium-4 and -10),
• Acrylamide copolymers (Polyquaternium-7),
• - Styleze® ^® CC-10, Aqua Flex ^® SF-40,
• - polyethyleneimines and their salts,
• - polyvinylamines and salts thereof, copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Luviquat ^® PQ 11, INCI: Polyquaternium-11),
• Copolymers of acrylamide and dimethyldiallylammonium chloride (Polyquaternium-7),
• Cationic cellulose derivatives (Polyquaternium-4, -10),
• Cationic starch derivatives (INCI: Starch Hydroxypropyltrimonium Chloride, Corn Starch Modified),
• - cationic guar derivatives (INCI: hydroxypropyl guar hydroxypropyltrimonium chlorides),
• Cationic sunflower oil derivatives (INCI: Sunflowerseedamidopropyl hydroxyethyldimonium chlorides),
• Copolymers of acrylic acid, acrylamide and methacrylamidopropyltrimonium chloride (INCI: Polyquaternium-53),
• - Polyquaternium-32,
• - Polyquaternium-28 and others.

As a further hair cosmetic polymers and neutral polymers are suitable as polyvinylpyrrolidone, copolymers of N-vinylpyrrolidone and vinyl acetate and / or vinyl propionate, copolymers of N-vinylpyrrolidone / Dimethylaminopropylacrylamid or -methacrylamide, copolymers of N-vinylpyrrolidone and alkyl acrylate or -methacrylatmonomeren with alkyl chains of C ₁ to C ₁₈ polysiloxanes, graft copolymers of polyvinyl alcohol on polyalkylene glycols such as Kollicoat ^® IR, graft copolymers of other vinyl monomers on polyalkylene glycols, polysiloxanes, polyvinylcaprolactam and copolymers with N-vinylpyrrolidone, polyethyleneimines and their salts, polyvinylamines and their salts, polyaspartic acid salts and derivatives.

These include those known under the trade name Luviskol ^® (K, VA, Plus), PVP K, PVP / VA, Advantage ^® HC and _H2 OLD EP ^® -1.

Also suitable are also biopolymers, i. Polymers made from naturally renewable Raw materials are obtained and built from natural monomer building blocks are, e.g. Cellulose derivatives, chitin, chitosan, DNA, hyaluronic acid and RNA derivatives.

to Setting certain properties, the preparations may also be Contain conditioning substances based on silicone compounds. Suitable silicone compounds are, for example, polyalkylsiloxanes, Polyarylsiloxanes, polyanilalkylsiloxanes, polyethersiloxanes, silicone resins, Dimethicones, dimethicone derivatives or dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA).

Other suitable polymers are also polymers such as betaines Yukaformer ^® (R205, SM) and Diaformer ^®.

The polymers according to the invention are particularly suitable as setting agents in hairstyling preparations, in particular hair sprays (aerosol sprays and pump sprays without propellant gas) and hair mousses (Aerosol foams and pump foams without propellant).

One Another object of the invention is thus the packaging of the cosmetic product in a nebulizer, pump bottle or aerosol container to get a spray, a varnish or a foam.

Prefers Here is the packaging of the cosmetic product in one Pump sprayer.

• a) 0,1 bis 10 Gew.-% der sulfonierten Polyaryletherketone
• b) 20 bis 99,9 Gew.-% Wasser und/oder Alkohol
• c) 0 bis 70 Gew.-% eines Treibmittel
• d) 0 bis 20 Gew.-% weitere Bestandteile

In a preferred embodiment, these preparations contain

• a) 0.1 to 10 wt .-% of the sulfonated polyaryletherketones
• b) 20 to 99.9% by weight of water and / or alcohol
• c) 0 to 70 wt .-% of a blowing agent
• d) 0 to 20 wt .-% further ingredients

propellant are the for Hairsprays or aerosol foams commonly used Propellant. Preference is given to mixtures of propane / butane, pentane, dimethyl ether, 1,1-difluoroethane (HFC-152a), carbon dioxide, nitrogen or compressed air.

• a) 0,1 bis 10 Gew.-% sulfonierten Polyaryletherketone
• b) 55 bis 99,8 Gew.-% Wasser und/oder Alkohol
• c) 5 bis 20 Gew.-% eines Treibmittel
• d) 0,1 bis 5 Gew.-% eines Emulgators
• e) 0 bis 10 Gew.-% weitere Bestandteile

A preferred formulation for aerosol hair foams according to the invention

• a) 0.1 to 10 wt .-% sulfonated polyaryletherketones
• b) 55 to 99.8% by weight of water and / or alcohol
• c) 5 to 20 wt .-% of a blowing agent
• d) 0.1 to 5 wt .-% of an emulsifier
• e) 0 to 10 wt .-% of further ingredients

When Emulsifiers can all in hair foams usually used emulsifiers are used. Suitable emulsifiers can nonionic, cationic or anionic or amphoteric.

Examples of nonionic emulsifiers (INCI nomenclature) are Laurethe, for example Laureth-4; Cetethe, eg, cetheth-1, polyethylene glycol cetyl ether; Ceteareth, eg Cetheareth-25, polyglycol fatty acid glycerides, hy droxylated lecithin, lactyl esters of fatty acids, alkylpolyglycosides.

Examples for cationic Emulsifiers are cetyltrimethylammonium chloride or bromide (INCI Cetrimonium chlorides or bromides), hydroxyethyl cetyldimonium phosphate (INCI Quaternium-44), INCI cocotrimonium methosulfate, INCI Quaternium-52, Quaternium-1 to x (INCI).

anionic Emulsifiers can for example, selected are selected from the group of alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, Alkylarylsulfonates, alkyl succinates, alkylsulfosuccinates, N-alkoylsarcosinates, alkyl glycol alkoxylates, Acyl taurates, acyl isethionates, alkyl phosphates, alkyl ether phosphates, Alkyl ether carboxylates, alpha olefin sulfonates, in particular the alkali and alkaline earth metal salts, e.g. Sodium, Potassium, magnesium, calcium, as well as ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can between 1 to 10 ethylene oxide or propylene oxide units, preferred 1 to 3 ethylene oxide units in the molecule.

• a) 0,1 bis 10 Gew.-% der sulfonierten Polyaryletherketone
• b) 60 bis 99,85 Gew.-% Wasser und/oder Alkohol
• c) 0,05 bis 10 Gew.-% eines Gelbildners
• d) 0 bis 20 Gew.-% weitere Bestandteile

A preparation suitable for styling gels according to the invention can be composed, for example, as follows:

• a) 0.1 to 10 wt .-% of the sulfonated polyaryletherketones
• b) 60 to 99.85% by weight of water and / or alcohol
• c) 0.05 to 10 wt .-% of a gelling agent
• d) 0 to 20 wt .-% further ingredients

When Gelbildner can all usual in cosmetics Gel former can be used. These include slightly crosslinked polyacrylic acid, for example Carbomer (INCI), cellulose derivatives, e.g. Hydroxypropyl cellulose, hydroxyethyl cellulose, cationically modified celluloses, polysaccharides, e.g. Xanthum Rubber, Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer, Polyquaternium-32 (and) Paraffin Liquidum (INCI), Sodium Acrylates Copolymer (and) Paraffin Liquidum (and) PPG-1 Trideceth-6, acrylamidopropyl Trimonium Chloride / Acrylamide Copolymer, Steareth-10 Allyl Ether Acrylates Copolymer, Polyquaternium-37 (and) Paraffin Liquidum (and) PPG-1 trideceth-6, Polyquaternium 37 (and) Propylene Glycol Dicaprate Dicaprylate (and) PPG-1 trideceth-6, polyquaternium-7, polyquaternium-44.

The sulfonated polyaryletherketones can be used in cosmetic preparations be used as a conditioning agent and / or as a thickening.

The According to the invention, sulfonated polyaryl ether ketones can also be used in Shampoo formulations as strengthening and / or conditioning agents be used.

• a) 0,05 bis 10 Gew.-% der sulfonierten Polyaryletherketone
• b) 25 bis 94,95 Gew.-% Wasser
• c) 5–50 Gew.-% Tenside
• c) 0–5 Gew.-% eines weiteren Konditioniermittels
• d) 0–10 Gew.-% weitere kosmetische Bestandteile

Contain preferred shampoo formulations

• a) 0.05 to 10 wt .-% of the sulfonated polyaryletherketones
• b) 25 to 94.95% by weight of water
• c) 5-50% by weight of surfactants
• c) 0-5 wt .-% of a further conditioning agent
• d) 0-10 wt .-% further cosmetic ingredients

In the shampoo formulations all in shampoos usually used anionic, neutral, amphoteric or cationic Surfactants are used.

suitable anionic surfactants are, for example, alkyl sulfates, alkyl ether sulfates, Alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-Alkoylsarkosinate, Acyl taurates, acyl isethionates, alkyl glycol alkoxylates, alkyl phosphates, Alkyl ether phosphates, alkyl ether carboxylates, alpha olefin sulfonates, in particular the alkali and alkaline earth metal salts, e.g. Sodium, Potassium, magnesium, calcium, as well as ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can between 1 to 10 ethylene oxide or propylene oxide units, preferably 1 to 3 ethylene oxide units in the molecule exhibit.

Suitable For example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, Ammonium lauryl ether sulfate, sodium lauroyl sarcosinate, sodium oleyl succinate, Ammonium laurylsulfosuccinate, sodium dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate.

Suitable amphoteric surfactants are, for example, alkylbetaines, alkylamidopropylbetaines, alkylsulfobetaines, alkylglycinates, alkylcarboxyglycinates, alkylamphoacetates or -propionates, alkylamphodiacetates or -dipropionate.

For example can Cocodimethyl sulphopropyl betaine, lauryl betaine, cocamidopropyl betaine or sodium cocamphopropionate.

When Nonionic surfactants are suitable, for example, the reaction products of aliphatic alcohols or alkylphenols having 6 to 20 C atoms in the alkyl chain, which may be linear or branched, with ethylene oxide and / or propylene oxide. The amount of alkylene oxide is about 6 up to 60 moles per one mole of alcohol. Furthermore, alkylamine oxides, mono- or dialkylalkanolamides, fatty acid esters of polyethylene glycols, ethoxylated fatty acid amides, alkyl polyglycosides, Alkyl glycol alkoxylates and diglycol alkoxylates or sorbitan ether esters suitable.

suitable anionic surfactants for the cosmetic according to the invention Preparations are, for example, alkyl sulfates, alkyl ether sulfates, Alkylsulfonates, alkylarylsulfones, alkylsuccinates, alkylsulfosuccinates, N-alkoyl sarcosinates, acyl taurates, acyl isethionates, alkyl phosphates, Alkyl ether phosphates, alkyl ether carboxylates, alpha olefin sulfonates, in particular the alkali and alkaline earth metal salts, e.g. Sodium, Potassium, magnesium, calcium, as well as ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates, alkyl glycol alkoxylates and -diglycol alkoxylates and alkyl ether carboxylates can be used between 1 to 10 ethylene oxide or propylene oxide units, preferably 1 to 3 ethylene oxide units in the molecule exhibit. Suitable examples are sodium lauryl sulfate, ammonium lauryl sulfate, Sodium lauryl ether sulfate, ammonium lauryl ether sulfate, sodium lauryl sarcosinate, Sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate, triethanolamine dodecyl benzene sulfonate.

In addition, the Medium usual cationic surfactants, e.g. quaternary ammonium compounds, for example Cetyltrimethylammonium chloride.

Become the (meth) acrylate polymers according to the invention used in shampoo formulations, they usually contain anionic surfactants as base surfactants and amphoteric and nonionic Surfactants as cosurfactants.

The Cosmetic preparations usually contain 2 to 50% by weight Surfactants, preferably 5 to 40 wt .-%, particularly preferably 8 to 30 % By weight.

In addition, the Shampoo formulations usual cationic surfactants, e.g. quaternary ammonium compounds, for example Cetyltrimethylammonium chloride or bromide (INCI Cetrimonium Chloride or bromide), hydroxyethyl cetyldimonium phosphate (INCI Quaternium-44), INCI cocotrimonium methosulfate, INCI Quaternium-52.

In the shampoo formulations customary conditioning agents can be used in combination with the polymers according to the invention to achieve certain effects. These include for example cationic polymers with the INCI name Polyquaternium, eg copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat ^® FC, Luviquat ^® HM, Luviquat ^® MS, Luviquat ^® Care, INCI: Polyquaternium-16, Polyquaternium-44), copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Luviquat ^® PQ 11, INCI: Polyquaternium-11), copolymers of N-vinyl caprolactam, N-vinylpyrrolidone / N-vinylimidazolium salts (Luviquat Hold ^®, INCI: Polyquaternium-46); Copolymers of acrylamide and dimethyldiallylammonium chloride (Polyquaternium-7), cationic cellulose derivatives (Polyquaternium-4, -10). Furthermore, cationic starch derivatives (INCI: Starch Hydroxypropytrimonium Chloride, Corn Starch Modified), cationic guar derivatives (INCI: Hydroxypropyl Guar Hydroxypropyltrimonium Chloride), cationic sunflower oil derivatives (INCI: Sunflowerseedamidopropyl Hydroxyethyldimonium Chloride), copolymers of acrylic acid, acrylamide and methacrylamidopropyltrimonium chloride (INCI: Polyquaternium - 53), Polyquaternium-32, Polyquaternium-28 and others. Furthermore, protein hydrolysates can be used, as well as conditioning substances based on silicone compounds, for example polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes or silicone resins. Other suitable silicone compounds are dimethicones, dimethicone derivatives or dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA).

emulsifiers

• (1) Anlagerungsprodukte von 2 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare Fettalkohole mit 8 bis 22 C-Atomen, an Fettsäuren mit 12 bis 22 C-Atomen und an Alkylphenole mit 8 bis 15 C-Atomen in der Alkylgruppe;
• (2) C12/18-Fettsäuremono- und -diester von Anlagerungsprodukten von 1 bis 30 Mol Ethylenoxid an Glycerin;
• (3) Glycerinmono- und -diester und Sorbitanmono- und -diester von gesättigten und ungesättigten Fettsäuren mit 6 bis 22 Kohlenstoffatomen und deren Ethylenoxidanlagerungsprodukte;
• (4) Alkylmono- und -oligoglycoside mit 8 bis 22 Kohlenstoffatomen im Alkylrest und deren ethoxylierte Analoga;
• (5) Anlagerungsprodukte von 15 bis 60 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes Ricinusöl;
• (6) Polyol- und insbesondere Polyglycerinester, wie z.B. Polyglycerinpolyricinoleat, Polyglycerinpoly-12-hydroxystearat oder Polyglycerindimerat. Ebenfalls geeignet sind Gemische von Verbindungen aus mehreren dieser Substanzklassen;
• (7) Anlagerungsprodukte von 2 bis 15 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes Ricinusöl;
• (8) Partialester auf Basis linearer, verzweigter, ungesättigter bzw. gesättigter C₆/₂₂-Fettsäuren, Ricinolsäure sowie 12-Hydroxystearinsäure und Glycerin, Polyglycerin, Pentaerythrit, Dipentaerythrit, Zuckeralkohole (z.B. Sorbit), Alkylglucoside (z.B. Methylglucosid, Butylglucosid, Laurylglucosid) sowie Polyglucoside (z.B. Cellulose);
• (9) Mono-, Di- und Trialkylphosphate sowie Mono-, Di- und/oder Tri-PEG-alkylphosphate und deren Salze;
• (10) Wollwachsalkohole;
• (11) Polysiloxan-Polyalkyl-Polyether-Copolymere bzw. entsprechende Derivate;
• (12) Mischester aus Pentaerythrit, Fettsäuren, Citronensäure und Fettalkohol gemäß DE-PS 1165574 und/oder Mischester von Fettsäuren mit 6 bis 22 Kohlenstoffatomen, Methylglycose und Polyolen, vorzugsweise Glycerin oder Polyglycerin sowie
• (13) Polyalkylenglykole.

Suitable emulsifiers for the cosmetic preparations according to the invention are, for example, nonionic surfactants from at least one of the following groups:

• (1) addition products of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide to linear fatty alcohols having 8 to 22 carbon atoms, to fatty acids having 12 to 22 carbon atoms and to alkylphenols having 8 to 15 carbon atoms in the alkyl group;
• (2) C12 / 18 fatty acid mono- and diesters of addition products of 1 to 30 moles of ethylene oxide with glycerol;
• (3) glycerol mono- and diesters and sorbitan mono- and diesters of saturated and unsaturated fatty acids having 6 to 22 carbon atoms and their ethylene oxide addition products;
• (4) alkyl mono- and oligoglycosides having 8 to 22 carbon atoms in the alkyl group and their ethoxylated analogs;
• (5) addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil;
• (6) polyol and especially polyglycerol esters such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxy stearate or polyglycerol dimerate. Also suitable are mixtures of compounds of several of these classes of substances;
• (7) addition products of 2 to 15 moles of ethylene oxide with castor oil and / or hydrogenated castor oil;
• (8) partial esters based on linear, branched, unsaturated or saturated C _6/22 fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (for example sorbitol), alkyl glucosides (for example methyl glucoside, butyl glucoside, lauryl glucoside) as well as polyglucosides (eg cellulose);
• (9) mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts;
• (10) wool wax alcohols;
• (11) polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives;
• (12) mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol according to DE-PS 1165574 and / or mixed esters of fatty acids having 6 to 22 carbon atoms, methylglycose and polyols, preferably glycerol or polyglycerol and
• (13) Polyalkylene glycols.

The addition products of ethylene oxide and / or of propylene oxide to fatty alcohols, fatty acids, alkylphenols, glycerol mono- and diesters and sorbitan mono- and diesters of fatty acids or to castor oil are known, commercially available products. These are mixtures of homologs whose mean Alkoxylierungsgrad the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate, with which the addition reaction is carried out corresponds. C ₁₂ to C ₁₈ fatty acid mono- and diesters of addition products of ethylene oxide with glycerol are known from DE-PS 2024051 as refatting agents for cosmetic preparations. C ₈ to C ₁₈ alkyl mono- and oligoglycosides, their preparation and their use are known from the prior art. They are prepared in particular by reacting glucose or oligosaccharides with primary alcohols having 8 to 18 carbon atoms. With respect to the glycoside ester, both monoglycosides in which a cyclic sugar residue is glycosidically linked to the fatty alcohol and oligomeric glycosides having a degree of oligomerization of preferably about 8 are suitable. The degree of oligomerization is a statistical mean, which is based on a homolog distribution typical for such technical products.

Farther can as emulsifiers zwitterionic surfactants are used. As zwitterionic Surfactants become such surface active Compounds referred to in the molecule at least one quaternary ammonium group and at least one carboxylate and / or sulfonate group. Particularly suitable zwitterionic surfactants are the so-called Betaines such as the N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinate, for example, the Kokosacylaminopropyldimethylammoniumglycinat, and 2-alkyl-3-carboxylmethyl-3-hydroxyethylimidazolines each 8 to 18 carbon atoms in the alkyl or acyl group and Kokosacylaminoethylhydroxyethylcarboxy methylglycinat.

Particularly preferred is the fatty acid amide derivative known under the CTFA name Cocamidopropyl Betaine. Also suitable emulsifiers are ampholytic surfactants. Ampholytic surfactants are understood as meaning those surface-active compounds which contain, in addition to a C ₈ to C ₁₈ -alkyl or -acyl group in the molecule, at least one free amino group and at least one -COOH and / or -SO ₃ H group and to form internal salts are capable. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 18 C Atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C ₁₂ to C ₁₈ acylsarcosine.

Next the ampholytic also includes quaternary emulsifiers, where those of the esterquat type, preferably methylquaternated Difatty acid triethanolamine ester salts, are particularly preferred.

preservative

When Preservative for the cosmetic according to the invention Preparations are, for example, phenoxyethanol, formaldehyde solution, parabens, Pentanediol or sorbic acid and the other listed in Appendix 6, Part A and B of the Cosmetics Regulation Classes.

perfume oils

Optionally, the cosmetic preparations may contain perfume oils. As perfume oils, for example, mixtures of natural and synthetic fragrances may be mentioned. Natural fragrances are extracts of flowers (lily, lavender, rose, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (aniseed, coriander, caraway, juniper), fruit peel (bergamot, lemon, Orange), Roots (Macis, Angelica, Celery, Cardamom, Costus, Iris, Calmus), Woods (Pine, Sandal, Guajac, Cedar, Rosewood), Herbs and Grasses (Tarragon, Lemongrass, Sage, Thyme), Needles and twigs (spruce, fir, pine, pines), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Furthermore, animal raw materials come into question, such as civet and Castoreum. Typical synthetic fragrance compounds are ester type products, ethers, aldehydes, ketones, alcohols and hydrocarbons. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, 4-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate and benzylsalicylate. The ethers include, for example, benzyl ethyl ether, to the aldehydes, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonate, to the ketones such as the ionones, cc-isomethyl ions and Methylcedrylketon to the alcohols Anethof, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terioneol, the hydrocarbons mainly include the terpenes and balsams. Preferably, however, mixtures of different fragrances are used, which together produce an attractive fragrance. Also essential oils of lower volatility, which are mostly used as aroma components, are suitable as perfume oils, eg sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon oil, lime blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil. Preferably, bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde, linalool, Boisambrene ^® Forte, Ambroxan ^®, indole, hedione, Sandelice, lemon oil, mandarin oil, orange oil, allyl amyl glycolate, Cyclovertal, lavandin , muscatel sage oil, geranium oil bourbon, cyclohexyl salicylate, Vertofix ^® Coeur, Iso-e-Super ^®, Fixolide ^® NP, Evernyl ^®, Iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romillat, irotyl and floramat-damascone β alone or in Mixtures used.

antioxidants

The Antioxidants for the cosmetic according to the invention Preparations are generally known compounds. Advantageous the antioxidants are selected from the groups of carotenoids, carotenes (e.g., α-carotene, β-carotene, lycopene) and theirs Derivatives, chlorogenic acid and their derivatives, lipoic acid and their derivatives (e.g., dihydrolipoic acid), further (metal) chelators, EDTA, EGTA and their derivatives, ubiquinone and ubiquinol and their derivatives Derivatives, vitamin C and derivatives (e.g., ascorbyl palmitate, Mg ascorbyl phosphate, Ascorbyl acetate), tocopherols and derivatives (e.g., vitamin E acetate), Vitamin A and derivatives (vitamin A palmitate), butylhydroxytoluene, Butylated hydroxyanisole, as well as more commonly used in cosmetic Preparations used antioxidants.

The Amount of the aforementioned antioxidants in the finished preparations is e.g. 0.001 to 30 wt .-%, preferably 0.01 to 10 wt .-% and in particular 1 to 5 wt .-%.

In the cosmetic according to the invention Preparations can the antioxidants are advantageously used together with Peroxidzersetzern become. In particular, you can synergistically effective combinations of antioxidants with peroxide decomposers be used. Preferably, antioxidants become synergistically more effective Combination with peroxide-decomposing boron compounds as in WO 03/059312 are described, used.

UV protection

The have sunscreen used in cosmetic preparations the task, damaging influences of Sunlight to prevent or at least prevent human skin to reduce their impact. In addition, these sunscreen serve but also the protection of other ingredients from destruction or Degradation by UV radiation. In hair cosmetic formulations is intended to damage the keratin fiber UV rays are reduced.

The to the earth's surface reaching sunlight has a share of UV-B (280 to 320 nm) and at UV-A radiation (320 to 400 nm), which directly to the Connect visible light area. The influence on the human Skin is particularly affected by UVB radiation from sunburn noticeable.

When a maximum of the erythema efficiency of sunlight becomes the tighter Range indicated around 308 nm.

To the Protection against UV-B radiation, numerous compounds are known which are u.a. to derivatives of the 3-benzylidene camphor, the 4-aminobenzoic acid, the cinnamic acid, salicylic acid, benzophenone and 2-phenylbenzimidazole.

Also for the Range between about 320 nm and about 400 nm, the so-called UV-A range, it is important Filter substances available to have since its rays cause reactions in photosensitive skin can. It has been proven that UV-A radiation to a damage the elastic and collagen fibers of the connective tissue performs what the skin prematurely leaves, and that you as the cause of numerous phototoxic and photoallergic reactions you can see. The injurious Influence of UV-B radiation can be amplified by UV-A radiation.

When UV sunscreen filters can be oil-soluble organic UV-A filter and / or UV-B filter and / or water-soluble organic UV-A filters and / or UV-B filters are used. The Total amount of UV photoprotective filters is usually 0.1 Wt .-% to 30 wt .-%, preferably 0.5 to 15 wt .-%, in particular 1 to 10 wt .-%, based on the total weight of the preparations.

advantageously, the UV protection filters are chosen so that the preparations skin protect against the entire range of ultraviolet radiation.

For example, UV protection filters are: No. material 1 4-aminobenzoic acid 2 3- (4'Trimethylammonium) -benrylidenbornan-2-one methyl sulfate 3 3,3,5-trimethyl-cyclohexyl-salicylate (homosalatum) 4 2-hydroxy-4-methoxybenzophenone (oxybenzone) 5 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and. triethanolamine 6 3,3 '- (1,4-phenylenedimethine) -bis (7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-methanesulfonic acid) and its salts 7 4-bis (polyethoxy) amino-ethyl ester benzoesäurepolyethoxy 8th 4-dimethylamino-benzoic acid 2-ethylhexyl ester 9 Salicylic acid 2-ethylhexyl ester 10 4-methoxy cinnamic acid-2-isoamyl 11 4-methoxy cinnamic acid-2-ethylhexyl 12 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid (sulisobenzone) and the sodium salt 13 3- (4'-sulfo) benzyliden-bornan-2-one and salts 14 3-benzylidenebornan-2-one 15 1- (4'-isopropylphenyl) -3-phenylpropane-1,3-dione 16 4-Isopropylbenrylsalicylat 17 2,4,6-Trianilin- (o-carbo-2'-ethylhexyl-1'-oxy) -1,3,5-triazine 18 3-imidazol-4-yl-acrylic acid and its ethyl ester 19 Menthyl-o-aminobenzoates or: 5-methyl-2- (1-methylethyl) -2-aminobenzoates 20 Glyceryl p-aminobenzoate or 4-aminobenzoic acid 1-glyceryl ester 21 2,2'-dihydroxy-4-methoxybenzophenone (dioxybenzone) 22 2-hydroxy-4-methoxy-4-methylbenzophenone (mexenone) 23 Triethanolamine salicylate 24 Dimethoxyphenylglyoxalic acid or: 3,4-dimethoxyphenylglyoxalic acid sodium 25 3- (4'-sulfo) benzyliden-bornan-2-one and its salts 26 2,2 ', 4,4'-tetrahydroxybenzophenone 27 2,2'-methylenebis [6 (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol] 28 2,2 '- (1,4-phenylene) -bis-1H-benzimidazole-4,6-disulfonic acid, Na salt 29 2,4-bis- [4- (2-ethylhexyloxy) -2-hydroxy] phenyl-6- (4-methoxyphenyl) - (1,3,5) triazine 30 3- (4-methylbenzylidene) -camphor 31 4-bis (polyethoxy) paraaminobenzoesäurepolyethoxyethylester 32 2,4-dihydroxybenzophenone 33 2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5,5'-disodium sulfonate

dyes

When Dyes can the for used for cosmetic purposes suitable and approved substances as described, for example, in the publication "Cosmetic Colorants" of the Dye Commission the Deutsche Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984, Pp. 81-106, are compiled. These dyes are usually in concentrations from 0.001 to 0.1 wt .-%, based on the total mixture used.

superfatting

As superfatting agent can Substances such as lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, Monoglycerides and fatty acid alkanolamides be used, the latter also as foam stabilizers serve.

fats

typical examples for Fats are glycerides, as waxes come u.a. Beeswax, carnauba wax, candelilla wax, Montan wax, paraffin wax or microwaxes, optionally in combination with hydrophilic waxes, e.g. Cetylstearyl alcohol or partial glycerides in question. As stabilizers can Metal salts of fatty acids, such as. Magnesium, calcium, aluminum and / or zinc stearate or Ricinoleat be used.

suitable Silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, cyclic ones Silicones as well as amino, fatty acid, alcohol, polyether, epoxy, fluorine, glycoside and / or alkyl-modified Silicone compounds that are both liquid at room temperature also resinous may be present.

Oral and dental care

The sulfonated polyaryletherketones are readily soluble in solvents and solvent mixtures with increased Water content. Because of the ability sulfonated polyaryl ether ketones, films with good mechanical properties Trainees can train they in preparations for the dental care can be used. Possible forms of deployment For example, toothpastes, toothbrush gels, chewing gums or mouthwashes.

Therefore are other items the invention, the use of the sulfonated polyaryletherketones in preparations for oral and dental care as well as oral and dental care products containing the sulfonated polyaryletherketones.

The sulfonated polyaryletherketones are preferred for this purpose in part or completely provided neutralized form. The sulfonated polyaryletherketones and the films thereof are preferably in salt form.

The Mouth and dental care products contain in addition to the sulfonated Polyaryletherketones for such means usual Ingredients such as grinding and polishing agents (for example Chalk), humectants (for example sorbitol, glycerol, polyethylene glycols), Surfactants (for example lauryl sulfate, betaines, alkyl polyglucosides), Aroma components, consistency regulators, deodorizing agents, swelling agents, Binders (for example carboxymethylcellulose, xanthan gum), Active ingredients against oral or Dental diseases, water-soluble Fluorine compounds (for example, sodium fluoride).

typical examples for anionic surfactants are soaps, alkylbenzenesulfonates, alkanesulfonates, Alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfofatty, Glycerol ether sulfates, hydroxy mixed ether sulfates, fatty acid amide (ether) sulfates, Mono- and dialkylsulfosuccinamates, sulfotriglycerides, amide soaps, ether and their salts, fatty acid isethionates, fatty acid sarcosinates, Fatty acid taurides, N-acylamino acids, such as for example, acyl lactylates, acyl tartrates, acyl glutamates and acylaspartates, Alkyl oligoglucoside sulfates, protein fatty acid condensates (in particular wheat-based vegetable products) and alkyl (ether) phosphates. If the anionic surfactants contain polyglycol ether chains, can this a conventional, but preferably a narrow homolog distribution exhibit. Typical examples of nonionic Surfactants are fatty alcohol polyglycol ethers, alkylphenol polyglycol ethers, Fatty acid polyglycol ester, fatty acid amide polyglycol ether, Fatty amine polyglycol ethers, alkoxylated triglycerides, mixed ethers or Mixed formals, glucuronic acid derivatives, Fatty acid N-alkyl glucamides, Protein hydrolysates (in particular vegetable products based on wheat), polyol Sugar esters, sorbitan esters, polysorbates and amine oxides. Sofem the nonionic Surfactants contain polyglycol ether chains, these may be a conventional, but preferably have a narrow homolog distribution. Typical examples of amphoteric or zwitterionic surfactants are aminopropionates, aminoglycinates. Preferably, the alkoxylated Carbonsäureestem addition olefinsulfonates, Betaines, monoglyceride (ether) sulfates and alkyl and / or alkenyl oligoglycosides as other surfactants mono- and dialkylsulfosuccinates and / or taurates added. The surfactants mentioned are exclusively known compounds. Regarding structure and production of this Substances are on relevant reviews For example, J. Falbe (ed.), "Surfactants in Consumer Products, "Springer Verlag, Berlin, 1987, pp. 54-124 or J. Falbe (ed.), "Catalysts, Surfactants and Mineral Oil Additives ", Thieme Verlag, Stuttgart, 1978, pp. 123-217 directed.

Of the Proportion of auxiliaries and additives is not critical in itself depending on the type of product to be formulated. Usually the proportion is 5 to 98, preferably 80 to 90 wt .-% -related the finished preparations amount.

pharmaceutical preparations

One The invention relates to pharmaceutical agents containing sulfonated and / or sulfur-containing polyaryletherketones and pharmaceutically customary Active ingredients and additives.

Solid pharmaceutical dosage forms such as tablets, capsules, pellets, granules, crystals, etc. are coated for very different reasons, ie provided with a film coating. So can at For example, a bad odor or taste masked and the ability to swallow can be improved. The stability of the active ingredient can be increased by the coating by less water vapor and oxygen reaches the inside of the tablet. The dosage forms look better and can be better distinguished by the incorporation of dyes. In addition, in particular, the release rate of the active ingredient can be adjusted by the film coating.

As a general rule one differentiates between instant release forms and slow release or slow release forms.

at Instant release forms are said to disintegrate the tablet and release it of the active substance from the dosage form, if possible not by the coating Therefore, the film coating must be fast in the gastric juice dissolve. In addition, he must over have good film properties. The tensile strength and the elongation at break should be high, so that the film coating mechanical effects withstand, how they in pharmaceutical processing - especially the packaging - and also while shipping or storage occur.

One often used product for coating of instant release tablets is hydroxypropylmethylcellulose (HPMC). Hydroxypropylmethylcellulose exhibits in aqueous solution at increasing concentration a steep increase in viscosity on. A similar Behavior also shows hydroxypropylcellulose (HPC).

There the film former solution When Coaten of tablets must be finely atomized and the droplets formed the surface The tablets must be well wetted and spread well the viscosity a certain limit (between 150 and 250 mPas), which is dependent on the type of spray nozzle and the Device, do not exceed. That's why in the case of HPMC only relatively low Filmbildnerkonzentrationen be used.

As a recommendation for the concentration of Pharmacoat ^® 606 (Messrs. Shin-etsu) are given in the literature 5 to 7 wt .-% (Pharmaceutical Coating Technology, ed. Graham Cole, Taylor and Francis Ltd. 1995 and technical data sheets of the manufacturer) , These low spray concentrations require relatively long processing times and thus high costs.

Furthermore Hydroxypropylmethylcellulose shows other disadvantages, among others. in wetting behavior, in pigment binding capacity, in the mechanical properties of the films, in hygroscopicity as well in the permeability across from Water vapor and oxygen, in the dissolution rate and in the disintegration time difference between film-coated tablets and core.

The low elasticity Of the films of hydroxypropylmethylcellulose often leads to the film-coated tablets tear when wet storage due to the swelling of the core. Also the use of plasticizers gives no appreciable improvements this problem. He can rather become sticky movies and through Migration to change lead the tablet properties.

oral Dosage forms with a drug release over a longer period with the aim the extension of effect The active component (generally sustained release medicines) are increasingly gaining in popularity in importance. With her is an improved patient compliance by a reduced frequency of intake, a reduction of side effects By avoiding plasma spikes, more consistent blood levels of the drug as well as the avoidance of local irritations connected favorably. In addition to the formulation of drug-containing cores containing a water but were coated semipermeable or porous film by the The drug can diffuse, control and extension the release by the embedding of the drug in matrices be achieved. Furthermore, the use of ion exchange resins and therapeutic systems (e.g., OROS).

Especially the embedding of the drug in hydrocolloid matrices offers the Advantages of a simple and inexpensive manufacture and a high Drug safety because can not occur dumping effects. The therefor usually used adjuvants such as hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, alginic acid or alginates and xanthan have application disadvantages. Here are: Lack of flow properties, which complicate a direct tableting, a dependency drug release from osmolarity (salinity) and pH of the release medium. This also applies to HPMC as well as for hydroxypropylcellulose, xanthan and alginates. The use of xanthan also leads to tablets low hardness, the direct tableting of alginates results in pressed bodies with only low retarding properties (max 8 h). The natural Swelling agents (e.g., alginates) as a whole have high batch variability.

binder are used in pharmaceutical dosage forms to treat the Processability and to increase the mechanical strength. she become common used in tablets, granules and pellets and lead to improved flowability, higher Breaking strength and lower friability.

The Currently used binders such as maltodextrin or polyvinylpyrrolidone to lead often to unsatisfactory breaking strengths and friability. Other Binders such as starch paste and hydroxypropylmethylcellulose (HPMC) can be distinguished by their high viscosity only use low concentration.

Farther film-forming auxiliaries are used in solutions and sprays, applied to the skin or mucous membrane or systemic to the body supplied become. Examples of this are preparations for the wound treatment, spray dressings but also preparations for application to intact skin or mucous membrane. The skin is protected by a film and the active ingredients in or penetrate through the skin.

at transdermal therapeutic systems and in wound plasters also as in the abovementioned dosage forms a sufficient flexibility not required by the currently available products exhibit. The use of possible Plasticizers to achieve the necessary flexibility is out toxicological and pharmacological reasons not desired.

A Object of the present invention was water-soluble or water-dispersible polymers as coating agents, binders and / or to provide film formers in pharmaceutical preparations, which do not have the above-mentioned disadvantages.

Surprisingly it was found that sulfonated and / or sulfur-containing polyaryletherketones for Use in pharmaceutical preparations are suitable.

she are particularly suitable as coating agents, Binders, film formers and also as a matrix for the drug release in pharmaceutical preparations.

The polymers according to the invention can used in a variety of pharmaceutical preparations become.

For example can called as coated Preparations film-coated tablets, film microtablets, dragees, coated Pastilles, capsules, crystals, granules or pellets.

at binder-containing preparations are, for example Tablets, microtablets, kernels, granules or pellets.

Farther can the sulfonated and / or sulfur-containing polyaryletherketones for the production of solutions and sprays applied to the skin or mucosa, to train a movie.

Examples therefor are spray dressings for wounds, Disinfecting sprays, solutions with mycostatica, oral sprays or solutions with antibiotics etc. The use in transdermal therapeutic systems possible.

The used according to the invention Moisten sulfonated and / or sulfur-containing polyaryletherketones slightly lipophilic surfaces and have excellent protective colloid properties. Incorporated in Suspensions and emulsions are deposited on the particles of the disperse phase and stabilize this. They can therefore be used as wetting aids and stabilizers are used in disperse systems.

By Improve interaction with poorly water-soluble drugs their solubility and dissolution rate, which improves absorbability and bioavailability of the drugs become. This advantageous effect is evident, for example the dosage forms in which the active substance is not dissolved, such as. Tablets, granules, suspensions etc.

If appropriate, the polymers used according to the invention can also be used in combination with other excipients to form active pharmaceutical agent melts which are either extruded and calendered into medicaments or are divided into granules or powders after extrusion and are subsequently processed in drug forms, for example Tablets are pressed the. The sulfonated and / or sulfur-containing polyaryletherketones bring the properties already listed above into the preparations.

In various pharmaceutical preparations, the sulfonated and / or sulfur-containing polyaryl ether ketones can fulfill the following functions outstandingly:
Dispersing aid, suspension adjuvant, wetting agent, solubilizer for sparingly soluble drugs, emulsifier, crystallization inhibitor, anticaking auxiliary, protective colloid, bioadhesive for prolonging and intensifying the contact with the mucous membrane, spreading aid, viscosity regulator, excipient for the preparation of solid solutions with drugs, adjuvant for adjusting the release of active ingredient in sustained-release formulations ,

The solubility the sulfonated and / or sulfur-containing polyaryletherketones can be adjusted as desired by suitable choice of the degree of sulfonation become.

So can in water not or only slightly soluble, but dispersible sulfonated polyaryl ether ketones also used as retardation polymers become.

at the use for the preparation of suppositories and vaginal globules guarantee the sulfonated polyaryl ketone on the one hand the flexibility of the dosage form and promote on the other hand, the disintegration and drug dissolution and they clothe the mucosa with a drug-containing film that enhances the absorption.

tablets sources in dependence of the auxiliaries and active substances used, the storage time and the storage conditions, like temperature and humidity, varying degrees. A rigid one film coating suffers cracks on swelling of the core. That is why the elasticity of film formers an important size.

The sulfonated, optionally neutralized polyaryl ether ketones can in pure form or together with the usual excipients on the active ingredient-containing core can be applied. Usual excipients are e.g. Color pigments for coloring, White pigments, like titanium dioxide, to increase hiding power, talc and silica as detackifiers, polyethylene glycols, Glycerol, propylene glycol, triacetin, triethyl citrate as plasticizer and various surface active Substances such as sodium lauryl sulfate, Polysorbate 80, Pluronics and Cremophore, to improve the wetting behavior. The examples mentioned Substances are not limiting. All known to be suitable for gastric juice-soluble film coatings Additives are used.

As a coating process can the usual Processes, such as coating in the fluidized bed or horizontal drum coater, the diving sword method and the boiler coating method. Next of application on tablets the sulfonated polyaryl ether ketones also for the coating of other pharmaceutical Preparations, such as granules, pellets, crystals or capsules, be used. The new coating agents be as usual in a strength from 5 to 200 μm, preferably 10 to 100 μm, applied.

at The use as a binder differs depending on the processing method between wet and dry binders. The latter are u.a. at Direct tableting and dry granulation or compaction used. Here, the binder with the active ingredient and optionally mixed with other excipients and then directly tableted or granulated or compacted.

in the In contrast, in wet granulation, the drug-excipient mixture with a solution of Binder moistened in water or an organic solvent, the wet mass passed through a sieve and then dried. Humidification and drying can thereby also run in parallel, such. in fluidized bed granulation.

For an optimal Processing, the binder should be low viscosity in solution, since viscous solutions too inhomogeneous granules.

One Binder should be uniform, hard, abrasion-stable granules or tablets lead. Especially with tablets The breaking strength is of particular importance, since many Drugs can be pressed poorly and thus tablets with inadequate mechanical stability result.

Farther should the disintegration of dosage forms and the release rate the active ingredients by the binder is not appreciably disadvantageous to be influenced.

The common Binders are, for example, polyvinylpyrrolidone, vinyl acetate-vinylpyrrolidone copolymers, Gelatin, starch paste, Maltodextrins, hydroxyalkylated or carboxyalkylated cellulose derivatives, such as hydroxypropylmethylcellulose, methylcellulose, sodium carboxymethylcellulose as well as natural Gums, such as gum arabic, pectin or alginate.

Lots these binders are in solution a high viscosity and are difficult to process. Due to the high viscosity wetting the powder particles to be granulated poorly and unevenly, then that from this a too low granule strength and an unfavorable particle size distribution result.

Lots Binders are also hygroscopic and swell when absorbed by water. Thereby can the granule and tablet properties change dramatically.

Surprisingly It has now been found that the sulfonated polyaryl ether ketones have excellent Binding effects have and also in concentration ranges of 0.5 to 20 wt .-%, preferably 1 to 10 wt .-% of the total amount of the formulation does not decomposition influence significantly. Due to the good wetting behavior In addition, the release of poorly soluble active ingredients can improve. Also worth mentioning is the comparatively low viscosity of the polymer solutions.

With The polymers as binders are mechanically extremely extraordinary stable and over long Storage times stable granules or tablets.

Example S1: Production Sulfonated Polyether Ether Ketones with Sulfonation Degrees (SG) from 78 to 80

500 g polyetheretherketone (VICTREX ^® PEEK 450 P) were dissolved with stirring (300 rpm) at 45 ° C within 16 hours in 6893 g of methanesulfonic acid and implemented. After addition of 1 386.6 g of oleum (25% SO ₃ ) was further stirred at 45 ° C for 4.5 hours. Thereafter, the solution was cooled to 20 ° C within 30 minutes and at the same time in demineralized water (VE = fully desalted) transferred. The polymer was precipitated in 3 fractions within 2.5 hours. The fractions were turraxiert, filtered off and washed with deionized water. After drying overnight at 50 ° C under vacuum (water jet pump) sulfonation degrees of 78, 79 and 80% were determined by elemental analysis in the so-sulfonated polyether ether.

Example E1: Preparation a film of sulfonated polyaryletherketone with SG 80

The for the Determination of the film properties necessary films were from a 10 wt .-% aqueous Solution, whose pH was adjusted to pH 6.9 with triethanolamine. From this polymer solution was isolated by knife-coating on a hot plate at about 45 ° C Film produced with a layer thickness of about 10 microns. Subsequently were homogeneous cuts punched out of the film and about 24 hours at a relative humidity stored at 54% and a temperature of 23 ° C. The thickness of the films was determined by a 3-point measurement with a Coating Thickness Gauge from the company. Erichsen certainly.

Tensile strength, elongation at break and modulus were determined by the Texture Analyzer ^® of the company Stable Micro Systems. The evaluation was carried out with the associated software Texture Expert ^® .

Elongation at break, Modulus of elasticity and tensile strength of the film were at 23 ° C and 11 %, 54 and 75% relative humidity.

stickiness

The polymer solution was doctored to determine the tack with a 120 micron doctor blade on a glass plate to films, these were dried and 24 hours in laboratory conditions (film 1), in the air cabinet at 20 ° C and 80% relative humidity (film 2) or 30 ° C and 75% relative humidity (film 3) stored.

Then the films were for 10 seconds with a stamping pressure of 2 bar with black color (punch diameter 5 cm). The stickiness correlates with the amount of black Color that remains on the polymer film after removal of the stamp, i.e. a strong black color the film shows a high stickiness.

The Assessment of stickiness is made by comparison with different strong black colored glass plates and gets through with grades from 0 (not sticky) to 5 (very sticky) Values recorded. This rating is in increments of 0.25.

solubility

The for determining the solubility necessary films were analogous to the films for the determination of mechanical Sizes produced. The film thickness was about 100 microns. From these films were cut and cut into a matching parts curious about conventional slide frames. The layer thickness was measured with a 5-point measurement on as possible high homogeneity checked.

The So clamped films were in a Paddleapparatur at 37 ° C in 0.08 mol / l HCl or phosphate buffer (pH 6.8) dipped in such a way that the Diarahmen each about 2 cm below the liquid surface or above the stirrer was. The filling quantity was 1000 ml, the stirring speed 50 Revolutions per minute (rpm).

Settlement time is the time at which the polymer film has the first hole. Dissolution time is the time when the polymer film is completely released from the frame.

These Times are each determined by human observation of the samples.

The Solve movies each completely in the specified media.

The about the same good solubility in these different, physiologically significant media shows the particularly good suitability of the sulfonated and / or sulfur-containing Polymers for the use according to the invention in pharmaceutical preparations.

The Films are readily soluble in water, hard and tack-free. they continue to show an excellent combination of properties from low tack, high tensile strength and high elongation. It should be emphasized that the modulus of elasticity over a wide humidity range has high values.

Claims (19)

Cosmetic compositions containing sulfonated and / or Sulfur-containing polyaryletherketones and customary in cosmetics additives. Cosmetic compositions according to claim 1, wherein the polyaryletherketones selected are from the group consisting of polyaryletherketones, polyaryletheretherketones, Polyaryletherketonketonen and Polyaryletheretherketonketonen. Cosmetic compositions according to one of claims 1 or 2, containing the sulfonated and / or sulfur-containing polyaryletherketones in an amount in the range of 0.001 to 20 wt .-%, based on the Total quantity. Cosmetic compositions according to one of claims 1 to 3, wherein the degree of sulfonation of polyaryletherketones greater than 50% is. Cosmetic compositions according to one of claims 1 to 4, wherein the degree of sulfonation of polyaryletherketones 80% or is larger. Cosmetic compositions according to one of claims 1 to 5, wherein the sulfonated polyaryl ether ketones partially or completely neutralized are. Cosmetic compositions according to one of claims 1 to 6, wherein the sulfonated polyaryletherketones partially or completely as Ammonium and / or alkali metal salts are present. Cosmetic composition according to one of claims 1 to 7, wherein the sulfonated polyaryletherketones were obtained by Reaction of at least one polyaryletherketone with at least one Alkane sulfonic acid. Cosmetic composition according to claim 8, wherein as alkanesulfonic methanesulfonic acid and / or As polyaryletherketone a polyetheretherketone were used. Cosmetic composition according to one of claims 1 to 7, wherein as a sulfonated polyaryletherketone a polyaryletherketone was used by further reaction of at least one sulfur containing polyaryletherketone as claimed in any one of claims 8 or 9 defined with at least one sulfonating agent was obtained. Cosmetic composition according to one of claims 1 to 10, wherein the sulfonated polyaryletherketones are present in a cosmetically acceptable solvent, wherein the solvent is selected from the group consisting of water, C ₂ - to C ₆ -alcohol, propylene glycol, glycerol, sorbitol or mixtures thereof , Cosmetic composition according to claim 11, wherein the solvent selected is selected from the group consisting of water, ethanol, i-propanol or Mixtures thereof. Cosmetic composition according to one of claims 1 to 12, wherein the agent is present as a gel, milk, cream, lotion or foam. Cosmetic composition according to one of claims 1 to 13, characterized in that it is a product for styling. Cosmetic composition according to one of claims 1 to 14, wherein the agent is a product for the hair that is among the shampoos and products for the hair selected is that rinsed out or not rinsed out and before or after shampooing, coloring, decolorization, perming or wrinkling be applied. Cosmetic composition according to one of claims 1 to 15, wherein the cosmetic composition in a nebulizer, pump bottle or aerosol container assembled is to get a spray, a varnish or a foam. Process for the treatment of hair, characterized that the Hair with the cosmetic agent according to one of claims 1 to 16 are brought into contact and optionally rinsed with water. Funds for containing the oral and dental care a) sulfonated polyaryl ether ketones, wherein the sulfonated polyaryletherketones according to one of claims 1 to 10 are defined and b) for the oral and dental care usual Additives. Use of sulfonated and / or sulfur-containing polyaryletherketones as in one of Claims 1 to 10 defined in pharmaceutical preparations.