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DE102004019845A1 - Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components - Google Patents

Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components Download PDF

Info

Publication number
DE102004019845A1
DE102004019845A1 DE200410019845 DE102004019845A DE102004019845A1 DE 102004019845 A1 DE102004019845 A1 DE 102004019845A1 DE 200410019845 DE200410019845 DE 200410019845 DE 102004019845 A DE102004019845 A DE 102004019845A DE 102004019845 A1 DE102004019845 A1 DE 102004019845A1
Authority
DE
Germany
Prior art keywords
components
inorganic carbonate
microcrystalline cellulose
perindopril
cholinesterase inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE200410019845
Other languages
German (de)
Inventor
Iztok Klobcar
Alesa Puncuh-Kolar
Anica Grandovec
Urska Turk
Polona Solmajer-Lampic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
KRKA Tovarna Zdravil dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KRKA Tovarna Zdravil dd filed Critical KRKA Tovarna Zdravil dd
Priority to DE200410019845 priority Critical patent/DE102004019845A1/en
Priority to LTEP05730288.7T priority patent/LT1729739T/en
Priority to HRP20161602TT priority patent/HRP20161602T1/en
Priority to EA200601608A priority patent/EA011712B1/en
Priority to DK05730288.7T priority patent/DK1729739T3/en
Priority to HUE05730288A priority patent/HUE031058T2/en
Priority to JP2007505484A priority patent/JP4948392B2/en
Priority to US10/599,154 priority patent/US20070172524A1/en
Priority to PT57302887T priority patent/PT1729739T/en
Priority to PL05730288T priority patent/PL1729739T3/en
Priority to PCT/EP2005/003277 priority patent/WO2005094793A1/en
Priority to EP05730288.7A priority patent/EP1729739B1/en
Priority to UAA200611343A priority patent/UA86969C2/en
Priority to ES05730288.7T priority patent/ES2603856T3/en
Publication of DE102004019845A1 publication Critical patent/DE102004019845A1/en
Priority to NO20064934A priority patent/NO20064934L/en
Priority to US12/477,727 priority patent/US20100172995A1/en
Priority to CY20161101118T priority patent/CY1118180T1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Solid pharmaceutical composition comprises perindopril or its salts, at least one of microcrystalline cellulose and anhydrous lactose, optionally at least one inorganic carbonate and optionally other components. The cellulose has a moisture content of 0.3-5 (preferably 0.3-1.5) wt.%. An independent claim is included for preparing the composition which comprises: (A) dry mixing perindopril or its salts with at least one inorganic carbonate, at least one carrier and optionally other components; and (B) dry processing the obtained mixture to a solid form. ACTIVITY : None given. No biological data is given. MECHANISM OF ACTION : Acetyl cholinesterase inhibitor.
DE200410019845 2004-03-29 2004-03-29 Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components Withdrawn DE102004019845A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE200410019845 DE102004019845A1 (en) 2004-03-29 2004-03-29 Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components
PL05730288T PL1729739T3 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
PCT/EP2005/003277 WO2005094793A1 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
EA200601608A EA011712B1 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
DK05730288.7T DK1729739T3 (en) 2004-03-29 2005-03-29 PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition.
HUE05730288A HUE031058T2 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
JP2007505484A JP4948392B2 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
US10/599,154 US20070172524A1 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
PT57302887T PT1729739T (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
LTEP05730288.7T LT1729739T (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
HRP20161602TT HRP20161602T1 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
EP05730288.7A EP1729739B1 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
UAA200611343A UA86969C2 (en) 2004-03-29 2005-03-29 Process for preparing a solid pharmaceutical composition
ES05730288.7T ES2603856T3 (en) 2004-03-29 2005-03-29 Procedure for preparing a solid pharmaceutical composition
NO20064934A NO20064934L (en) 2004-03-29 2006-10-27 Process for the preparation of a solid pharmaceutical composition
US12/477,727 US20100172995A1 (en) 2004-03-29 2009-06-03 Process For Preparing A Solid Pharmaceutical Composition
CY20161101118T CY1118180T1 (en) 2004-03-29 2016-11-03 METHOD FOR PRODUCTION OF SOLID PHARMACEUTICAL COMPOSITION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200410019845 DE102004019845A1 (en) 2004-03-29 2004-03-29 Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components

Publications (1)

Publication Number Publication Date
DE102004019845A1 true DE102004019845A1 (en) 2005-10-20

Family

ID=35456073

Family Applications (1)

Application Number Title Priority Date Filing Date
DE200410019845 Withdrawn DE102004019845A1 (en) 2004-03-29 2004-03-29 Solid composition used as acetyl cholinesterase inhibitor comprises perindopril, microcrystalline cellulose, inorganic carbonate and other components

Country Status (2)

Country Link
DE (1) DE102004019845A1 (en)
UA (1) UA86969C2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025374A1 (en) * 1997-11-19 1999-05-27 Adir Et Compagnie Combination of hypertensin converting enzyme inhibitor with a diuretic for treating microcirculation disorders
WO2001097809A2 (en) * 2000-06-16 2001-12-27 Wyeth Method of treating cardiovascular disease using rapamycin
FR2834893A1 (en) * 2002-01-23 2003-07-25 Servier Lab ORODISPERSIBLE PHARMACEUTICAL COMPOSITION OF PERINDOPRIL
US20030215526A1 (en) * 2002-03-08 2003-11-20 Scott Stofik Stable formulations of angiotensin converting enzyme (ACE) inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025374A1 (en) * 1997-11-19 1999-05-27 Adir Et Compagnie Combination of hypertensin converting enzyme inhibitor with a diuretic for treating microcirculation disorders
WO2001097809A2 (en) * 2000-06-16 2001-12-27 Wyeth Method of treating cardiovascular disease using rapamycin
FR2834893A1 (en) * 2002-01-23 2003-07-25 Servier Lab ORODISPERSIBLE PHARMACEUTICAL COMPOSITION OF PERINDOPRIL
US20030215526A1 (en) * 2002-03-08 2003-11-20 Scott Stofik Stable formulations of angiotensin converting enzyme (ACE) inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Serva-Spezifikation unter www.serva.de/products/ pdf/14204.pdf(gutachtlich Stellungsnahme) *

Also Published As

Publication number Publication date
UA86969C2 (en) 2009-06-10

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20131001